norethynodrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids, progestogens	1965	68-23-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: norethynodrel norethinodrel noretynodrel	A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and ENDOMETRIOSIS. As a contraceptive (CONTRACEPTIVE AGENTS), it has usually been administered in combination with MESTRANOL. Molecular weight: 298.43 Formula: C20H26O2 CLOGP: 2.65 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -4.48 ROTB: 0 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

norethynodrel
norethinodrel
noretynodrel

A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and ENDOMETRIOSIS. As a contraceptive (CONTRACEPTIVE AGENTS), it has usually been administered in combination with MESTRANOL.

Molecular weight: 298.43
Formula: C20H26O2
CLOGP: 2.65
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -4.48
ROTB: 0

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
March 9, 1961	FDA	GD SEARLE LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G03FA09	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, fixed combinations
MeSH PA	D003270	Contraceptive Agents
MeSH PA	D003271	Contraceptive Agents, Female
MeSH PA	D000080066	Contraceptive Agents, Hormonal
MeSH PA	D003278	Contraceptives, Oral, Hormonal
MeSH PA	D003280	Contraceptives, Oral, Synthetic
MeSH PA	D012102	Reproductive Control Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID
Contraception	indication	13197004
Female hypogonadism syndrome	indication	16041008
Endometriosis	indication	129103003
Menorrhagia	indication	386692008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN	AGONIST				CHEMBL	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		IC50	5.81		CHEMBL

External reference:

ID	Source
4018120	VUID
N0000146458	NUI
D05207	KEGG_DRUG
4018120	VANDF
C0028360	UMLSCUI
CHEBI:34895	CHEBI
CHEMBL1387	ChEMBL_ID
DB09371	DRUGBANK_ID
D009641	MESH_DESCRIPTOR_UI
6231	PUBCHEM_CID
1257	INN_ID
88181ACA0M	UNII
7515	RXNORM
001297	NDDF
126107003	SNOMEDCT_US
82133001	SNOMEDCT_US

Pharmaceutical products:

None