etynodiol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1095 297-76-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethynodiol
  • etynodiol
  • ethinodiol
  • etynodiol acetate
  • ethynodiol diacetate
  • ethinodiol diacetate
  • ethynodiol acetate
A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive (CONTRACEPTIVES, ORAL).
  • Molecular weight: 384.52
  • Formula: C24H32O4
  • CLOGP: 5.13
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -4.99
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.04 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
March 23, 1966 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03AA01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03DC06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Estren derivatives
ATC G03FA06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
FDA Chemical/Ingredient N0000011301 Progesterone Congeners
FDA EPC N0000175602 Progestin
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D003280 Contraceptives, Oral, Synthetic
MeSH PA D012102 Reproductive Control Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004
Polycystic ovaries off-label use 69878008
Heart valve disorder contraindication 368009 DOID:4079
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Depressive disorder contraindication 35489007
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Hyperlipidemia contraindication 55822004 DOID:1168
Benign mammary dysplasia contraindication 57993004
Obstructive hyperbilirubinemia contraindication 59848001
Thrombophlebitis contraindication 64156001 DOID:3875
Intermenstrual bleeding - irregular contraindication 64996003
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Malignant neoplasm of liver contraindication 93870000 DOID:3571
Deep venous thrombosis contraindication 128053003
Liver function tests abnormal contraindication 166603001
Angina pectoris contraindication 194828000
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Cholestasis of pregnancy contraindication 235888006
Endometrial carcinoma contraindication 254878006 DOID:2871
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Malignant tumor of cervix contraindication 363354003 DOID:4362
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Porphyria contraindication 418470004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Nonspecific Abnormal Papanicolaou Smear of Cervix contraindication
Major Surgery with Prolonged Post-Operative Immobilization contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor AGONIST WOMBAT-PK CHEMBL
Amine oxidase [flavin-containing] A Enzyme IC50 5.37 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor WOMBAT-PK
Androgen receptor Transcription factor Ki 5.68 DRUG MATRIX
Progesterone receptor Transcription factor Ki 7.68 DRUG MATRIX

External reference:

IDSource
D005040 MESH_DESCRIPTOR_UI
C0059849 UMLSCUI
D01294 KEGG_DRUG
62H10A1236 UNII
420879007 SNOMEDCT_US
423440008 SNOMEDCT_US
d03073 MMSL
24591 RXNORM
004939 NDDF
1336 INN_ID
1231-93-2 SECONDARY_CAS_RN
CHEBI:50785 CHEBI
C014546 MESH_SUPPLEMENTAL_RECORD_UI
DB00823 DRUGBANK_ID
CHEMBL1200624 ChEMBL_ID
14687 PUBCHEM_CID
CHEMBL1201406 ChEMBL_ID
7072 IUPHAR_LIGAND_ID
DB13866 DRUGBANK_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Kelnor 1/50 HUMAN PRESCRIPTION DRUG LABEL 2 0093-8073 KIT 1 mg None ANDA 15 sections
ETHYNODIOL DIACETATE AND ETHINYL ESTRADIOL HUMAN PRESCRIPTION DRUG LABEL 2 0378-7306 KIT 1 mg None ANDA 14 sections
ETHYNODIOL DIACETATE AND ETHINYL ESTRADIOL HUMAN PRESCRIPTION DRUG LABEL 2 0378-7307 KIT 1 mg None ANDA 15 sections
Kelnor 1/35 HUMAN PRESCRIPTION DRUG LABEL 2 0555-9064 KIT 1 mg None ANDA 15 sections
Zovia 1/35 HUMAN PRESCRIPTION DRUG LABEL 2 51862-260 KIT 1 mg None ANDA 15 sections
Zovia 1/35 HUMAN PRESCRIPTION DRUG LABEL 2 53002-1591 KIT 1 mg None ANDA 15 sections
Zovia 1/35E-28 HUMAN PRESCRIPTION DRUG LABEL 2 54868-4240 KIT 1 mg ORAL ANDA 14 sections
Zovia 1/50E-28 HUMAN PRESCRIPTION DRUG LABEL 2 54868-4778 KIT 1 mg ORAL ANDA 14 sections
Kelnor 1/35 HUMAN PRESCRIPTION DRUG LABEL 2 54868-5942 KIT 1 mg None ANDA 15 sections