trimegestone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 4736 74513-62-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimegestone
  • trimegeston
ligand for progesterone receptor
  • Molecular weight: 342.48
  • Formula: C22H30O3
  • CLOGP: 3.54
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 54.37
  • ALOGS: -4.26
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.081 Moderate 0.71
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.962 Moderate 0.71
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 59.704 10^-6 cm/s Moderate 0.71
dh-clint Dog hepatocyte intrinsic clearance 28.708 uL/min/10^6 cells Moderate 0.71
dppb Dog plasma protein binding (% unbound) 5.780 % Moderate 0.71
fcs-ppb Fetal calf serum protein binding (% unbound) 9.820 % Moderate 0.71
herg hERG pIC50 4.625 pIC50 Moderate 0.71
hh-clint Human hepatocyte intrinsic clearance 10.568 uL/min/10^6 cells Moderate 0.71
hlm-clint Human liver microsomal intrinsic clearance 154.170 uL/min/mg protein Moderate 0.71
hppb Human plasma protein binding (% unbound) 4.650 % Moderate 0.71
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,NTRK2,PDK1,PDK2,PDK4,PRKDC 15
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6 3
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.466 Moderate 0.71
mh-clint Mouse hepatocyte intrinsic clearance 121.899 Moderate 0.71
mppb Mouse plasma protein binding (% unbound) 6.390 Moderate 0.71
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 8.511 Moderate 0.71
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 16.440 % Moderate 0.71
rh-clint Rat hepatocyte intrinsic clearance 114.815 uL/min/10^6 cells Moderate 0.71
rh-fuinc Rat hepatocyte fraction unbound in incubation 50.290 % Moderate 0.71
rppb Rat plasma protein binding (% unbound) 9.340 % Moderate 0.71
solubility-dd Solubility at pH 7.4 in DMSO 97.499 uM Moderate 0.71

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03FA16 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
ATC G03FB11 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, sequential preparations

Related Drugs by ATC class:

G03FA Progestogens and estrogens, fixed combinations 15 drugs
dienogestdrospirenonedydrogesteroneethisteroneetynodiolhydroxyprogesterone caproatelevonorgestrellynestrenolmedroxyprogesteronemegestrol acetatemethylestrenolonenorethisterone show all 15 →
G03FB Progestogens and estrogens, sequential preparations 10 drugs
chlormadinonedesogestreldydrogesteronelevonorgestrellynestrenolmedrogestonemedroxyprogesteronemegestrol acetatenomegestrolnorethisterone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.36 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06235 KEGG_DRUG
CHEBI:136027 CHEBI
CHEMBL2104765 ChEMBL_ID
C050319 MESH_SUPPLEMENTAL_RECORD_UI
DB13129 DRUGBANK_ID
4658K0H08W UNII
015322 NDDF
C0628822 UMLSCUI
6897 INN_ID
68926 PUBCHEM_CID

Pharmaceutical products:

None