Stem definition | Drug id | CAS RN |
---|---|---|
steroids, progestogens | 818 | 54024-22-5 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.32 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.01 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 5 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 10, 1992 | FDA | ORGANON USA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Muscle injury | 1477.33 | 24.81 | 609 | 36398 | 29157 | 53282902 |
Folliculitis | 1473.60 | 24.81 | 619 | 36388 | 31090 | 53280969 |
Irritable bowel syndrome | 1323.74 | 24.81 | 632 | 36375 | 43000 | 53269059 |
Lower respiratory tract infection | 1266.57 | 24.81 | 786 | 36221 | 90195 | 53221864 |
Impaired healing | 1075.01 | 24.81 | 625 | 36382 | 63580 | 53248479 |
Blister | 1001.71 | 24.81 | 643 | 36364 | 78110 | 53233949 |
Sleep disorder due to general medical condition, insomnia type | 964.92 | 24.81 | 425 | 36582 | 23924 | 53288135 |
Ill-defined disorder | 931.25 | 24.81 | 520 | 36487 | 48924 | 53263135 |
Gastrointestinal disorder | 893.13 | 24.81 | 630 | 36377 | 89374 | 53222685 |
Sinusitis | 853.97 | 24.81 | 796 | 36211 | 167768 | 53144291 |
Stomatitis | 848.55 | 24.81 | 632 | 36375 | 97526 | 53214533 |
Peripheral swelling | 742.14 | 24.81 | 809 | 36198 | 205299 | 53106760 |
Therapeutic product effect decreased | 667.74 | 24.81 | 610 | 36397 | 125045 | 53187014 |
Joint swelling | 603.90 | 24.81 | 776 | 36231 | 233862 | 53078197 |
Pruritus | 571.87 | 24.81 | 849 | 36158 | 292983 | 53019076 |
Infection | 545.60 | 24.81 | 633 | 36374 | 171572 | 53140487 |
Nasopharyngitis | 529.26 | 24.81 | 658 | 36349 | 191637 | 53120422 |
Weight increased | 521.91 | 24.81 | 674 | 36333 | 203893 | 53108166 |
Swelling | 500.51 | 24.81 | 638 | 36369 | 190467 | 53121592 |
Duodenal ulcer perforation | 468.09 | 24.81 | 296 | 36711 | 34887 | 53277172 |
Hypersensitivity | 466.68 | 24.81 | 648 | 36359 | 210017 | 53102042 |
Confusional state | 464.35 | 24.81 | 620 | 36387 | 193601 | 53118458 |
Helicobacter infection | 454.20 | 24.81 | 302 | 36705 | 38767 | 53273292 |
Muscle spasticity | 369.40 | 24.81 | 200 | 36807 | 17638 | 53294421 |
Rash | 330.45 | 24.81 | 858 | 36149 | 445333 | 52866726 |
Pericarditis | 322.61 | 24.81 | 303 | 36704 | 64103 | 53247956 |
Anti-cyclic citrullinated peptide antibody positive | 321.51 | 24.81 | 287 | 36720 | 56885 | 53255174 |
Contraindicated product administered | 312.95 | 24.81 | 426 | 36581 | 135203 | 53176856 |
Night sweats | 281.17 | 24.81 | 216 | 36791 | 34731 | 53277328 |
Contusion | 269.36 | 24.81 | 357 | 36650 | 110375 | 53201684 |
Ear pain | 266.71 | 24.81 | 196 | 36811 | 29477 | 53282582 |
Body temperature increased | 264.47 | 24.81 | 203 | 36804 | 32596 | 53279463 |
Discomfort | 248.02 | 24.81 | 318 | 36689 | 95154 | 53216905 |
Respiratory disorder | 246.78 | 24.81 | 198 | 36809 | 33899 | 53278160 |
Hand deformity | 228.87 | 24.81 | 288 | 36719 | 84561 | 53227498 |
Pyrexia | 228.02 | 24.81 | 704 | 36303 | 402489 | 52909570 |
Death | 220.27 | 24.81 | 6 | 37001 | 357226 | 52954833 |
Glossodynia | 205.80 | 24.81 | 298 | 36709 | 99993 | 53212066 |
Synovitis | 203.31 | 24.81 | 308 | 36699 | 107585 | 53204474 |
Pemphigus | 196.04 | 24.81 | 297 | 36710 | 103734 | 53208325 |
Wound | 187.75 | 24.81 | 272 | 36735 | 91285 | 53220774 |
Hepatic enzyme increased | 180.47 | 24.81 | 318 | 36689 | 125877 | 53186182 |
Arthralgia | 177.77 | 24.81 | 687 | 36320 | 439096 | 52872963 |
Pneumonia | 177.30 | 24.81 | 34 | 36973 | 407135 | 52904924 |
Systemic lupus erythematosus | 160.23 | 24.81 | 301 | 36706 | 125113 | 53186946 |
Fall | 155.85 | 24.81 | 30 | 36977 | 358410 | 52953649 |
Sleep disorder | 143.25 | 24.81 | 190 | 36817 | 58680 | 53253379 |
Pain | 141.86 | 24.81 | 790 | 36217 | 587608 | 52724451 |
Arthropathy | 138.46 | 24.81 | 304 | 36703 | 141149 | 53170910 |
Acute kidney injury | 129.58 | 24.81 | 13 | 36994 | 253855 | 53058204 |
Infusion related reaction | 129.35 | 24.81 | 314 | 36693 | 155643 | 53156416 |
Nausea | 129.25 | 24.81 | 204 | 36803 | 755887 | 52556172 |
Toxicity to various agents | 124.06 | 24.81 | 7 | 37000 | 219591 | 53092468 |
Anaemia | 122.69 | 24.81 | 22 | 36985 | 276696 | 53035363 |
Urticaria | 109.88 | 24.81 | 271 | 36736 | 135614 | 53176445 |
Hypotension | 108.79 | 24.81 | 22 | 36985 | 254054 | 53058005 |
Insomnia | 97.27 | 24.81 | 318 | 36689 | 186754 | 53125305 |
Malaise | 96.47 | 24.81 | 65 | 36942 | 357552 | 52954507 |
Dyspnoea | 94.73 | 24.81 | 712 | 36295 | 585520 | 52726539 |
Pregnancy on oral contraceptive | 81.29 | 24.81 | 32 | 36975 | 1347 | 53310712 |
Drug hypersensitivity | 80.22 | 24.81 | 42 | 36965 | 265200 | 53046859 |
Dehydration | 75.42 | 24.81 | 13 | 36994 | 168397 | 53143662 |
Decreased appetite | 74.49 | 24.81 | 28 | 36979 | 214946 | 53097113 |
Urinary tract infection | 74.01 | 24.81 | 37 | 36970 | 239866 | 53072193 |
Abdominal discomfort | 73.62 | 24.81 | 326 | 36681 | 220736 | 53091323 |
Weight decreased | 72.83 | 24.81 | 36 | 36971 | 234912 | 53077147 |
Neutropenia | 69.74 | 24.81 | 13 | 36994 | 159172 | 53152887 |
Oedema peripheral | 68.61 | 24.81 | 17 | 36990 | 170770 | 53141289 |
Alopecia | 67.86 | 24.81 | 332 | 36675 | 234251 | 53077808 |
Drug intolerance | 67.62 | 24.81 | 302 | 36705 | 205191 | 53106868 |
Product dose omission issue | 66.31 | 24.81 | 25 | 36982 | 191595 | 53120464 |
Sepsis | 66.23 | 24.81 | 11 | 36996 | 146418 | 53165641 |
Atrial fibrillation | 64.77 | 24.81 | 3 | 37004 | 111649 | 53200410 |
Renal failure | 63.25 | 24.81 | 5 | 37002 | 118447 | 53193612 |
Hyponatraemia | 62.74 | 24.81 | 3 | 37004 | 108604 | 53203455 |
Cough | 62.37 | 24.81 | 52 | 36955 | 256841 | 53055218 |
Febrile neutropenia | 60.29 | 24.81 | 3 | 37004 | 104933 | 53207126 |
Abdominal pain upper | 58.19 | 24.81 | 249 | 36758 | 166042 | 53146017 |
Dizziness | 57.27 | 24.81 | 107 | 36900 | 372152 | 52939907 |
White blood cell count decreased | 57.08 | 24.81 | 9 | 36998 | 124466 | 53187593 |
Platelet count decreased | 56.51 | 24.81 | 5 | 37002 | 108094 | 53203965 |
Pain in extremity | 56.31 | 24.81 | 69 | 36938 | 284981 | 53027078 |
Blood pressure increased | 54.47 | 24.81 | 15 | 36992 | 140464 | 53171595 |
Therapeutic product effect incomplete | 51.55 | 24.81 | 3 | 37004 | 91781 | 53220278 |
Hypertension | 50.67 | 24.81 | 49 | 36958 | 225382 | 53086677 |
Somnolence | 50.02 | 24.81 | 27 | 36980 | 167707 | 53144352 |
Bronchitis | 49.29 | 24.81 | 9 | 36998 | 111890 | 53200169 |
Respiratory failure | 49.06 | 24.81 | 6 | 37001 | 100506 | 53211553 |
Constipation | 48.33 | 24.81 | 40 | 36967 | 198372 | 53113687 |
Gait disturbance | 48.20 | 24.81 | 25 | 36982 | 158817 | 53153242 |
Thrombocytopenia | 46.49 | 24.81 | 19 | 36988 | 138708 | 53173351 |
Blood creatinine increased | 45.53 | 24.81 | 3 | 37004 | 82659 | 53229400 |
Neuropathy peripheral | 43.97 | 24.81 | 9 | 36998 | 103178 | 53208881 |
Pancytopenia | 43.00 | 24.81 | 6 | 37001 | 90922 | 53221137 |
Overdose | 42.71 | 24.81 | 11 | 36996 | 107725 | 53204334 |
Haemoglobin decreased | 42.57 | 24.81 | 21 | 36986 | 137286 | 53174773 |
Injection site pain | 42.31 | 24.81 | 13 | 36994 | 113378 | 53198681 |
Feeling abnormal | 41.49 | 24.81 | 21 | 36986 | 135280 | 53176779 |
Fatigue | 40.99 | 24.81 | 722 | 36285 | 729784 | 52582275 |
Condition aggravated | 40.90 | 24.81 | 91 | 36916 | 297043 | 53015016 |
Renal impairment | 40.60 | 24.81 | 5 | 37002 | 83313 | 53228746 |
Myalgia | 40.51 | 24.81 | 21 | 36986 | 133470 | 53178589 |
Leukopenia | 39.49 | 24.81 | 3 | 37004 | 73460 | 53238599 |
Maternal exposure during pregnancy | 37.82 | 24.81 | 210 | 36797 | 155429 | 53156630 |
Faecal volume decreased | 36.87 | 24.81 | 11 | 36996 | 196 | 53311863 |
Hypokalaemia | 36.13 | 24.81 | 11 | 36996 | 96506 | 53215553 |
Cellulitis | 35.97 | 24.81 | 5 | 37002 | 75984 | 53236075 |
Cerebrovascular accident | 35.89 | 24.81 | 14 | 36993 | 105160 | 53206899 |
Cardiac failure | 35.53 | 24.81 | 8 | 36999 | 85836 | 53226223 |
Pleural effusion | 35.19 | 24.81 | 9 | 36998 | 88570 | 53223489 |
Herpes zoster | 34.73 | 24.81 | 5 | 37002 | 74014 | 53238045 |
Blood glucose increased | 34.55 | 24.81 | 6 | 37001 | 77355 | 53234704 |
Syncope | 33.41 | 24.81 | 18 | 36989 | 111975 | 53200084 |
Tension | 32.33 | 24.81 | 23 | 36984 | 3283 | 53308776 |
Septic shock | 32.19 | 24.81 | 3 | 37004 | 62226 | 53249833 |
Gastrooesophageal reflux disease | 31.71 | 24.81 | 9 | 36998 | 82654 | 53229405 |
Aspartate aminotransferase increased | 30.69 | 24.81 | 10 | 36997 | 84019 | 53228040 |
Hospitalisation | 30.65 | 24.81 | 6 | 37001 | 71006 | 53241053 |
Cardio-respiratory arrest | 29.95 | 24.81 | 3 | 37004 | 58755 | 53253304 |
Erythema | 29.91 | 24.81 | 39 | 36968 | 156930 | 53155129 |
Off label use | 29.61 | 24.81 | 199 | 36808 | 472013 | 52840046 |
Upper respiratory tract infection | 29.49 | 24.81 | 6 | 37001 | 69091 | 53242968 |
Coma | 29.39 | 24.81 | 4 | 37003 | 61779 | 53250280 |
Arthritis | 29.16 | 24.81 | 12 | 36995 | 87286 | 53224773 |
Asthma | 29.04 | 24.81 | 20 | 36987 | 108952 | 53203107 |
Alanine aminotransferase increased | 28.78 | 24.81 | 15 | 36992 | 95080 | 53216979 |
Loss of personal independence in daily activities | 27.91 | 24.81 | 7 | 37000 | 69808 | 53242251 |
Hypoglycaemia | 27.65 | 24.81 | 4 | 37003 | 59009 | 53253050 |
Tachycardia | 27.35 | 24.81 | 21 | 36986 | 108191 | 53203868 |
Muscle spasms | 27.24 | 24.81 | 32 | 36975 | 134763 | 53177296 |
Depressed level of consciousness | 27.17 | 24.81 | 3 | 37004 | 54425 | 53257634 |
Chest pain | 27.17 | 24.81 | 57 | 36950 | 190128 | 53121931 |
Chills | 26.95 | 24.81 | 20 | 36987 | 104828 | 53207231 |
Cardiac arrest | 26.59 | 24.81 | 16 | 36991 | 93651 | 53218408 |
Depression | 26.03 | 24.81 | 55 | 36952 | 182997 | 53129062 |
Hypoaesthesia | 25.38 | 24.81 | 33 | 36974 | 132962 | 53179097 |
Diarrhoea | 24.96 | 24.81 | 296 | 36711 | 625250 | 52686809 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|
Source | Code | Description |
---|---|---|
ATC | G03AA09 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations |
ATC | G03AB05 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, sequential preparations |
ATC | G03AC09 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens |
ATC | G03FB10 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, sequential preparations |
FDA CS | M0447349 | Progesterone Congeners |
FDA EPC | N0000175602 | Progestin |
CHEBI has role | CHEBI:49323 | contraceptive agent |
CHEBI has role | CHEBI:49326 | synthetic oral contraceptives |
CHEBI has role | CHEBI:59826 | progestins |
MeSH PA | D003270 | Contraceptive Agents |
MeSH PA | D003271 | Contraceptive Agents, Female |
MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
MeSH PA | D003278 | Contraceptives, Oral, Hormonal |
MeSH PA | D003280 | Contraceptives, Oral, Synthetic |
MeSH PA | D006728 | Hormones |
MeSH PA | D011372 | Progestins |
MeSH PA | D012102 | Reproductive Control Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Contraception | indication | 13197004 | |
Amenorrhea | off-label use | 14302001 | DOID:13938 |
Female hypogonadism syndrome | off-label use | 16041008 | |
Polycystic ovaries | off-label use | 69878008 | |
Dysmenorrhea | off-label use | 266599000 | |
Abnormal uterine bleeding unrelated to menstrual cycle | off-label use | 312984006 | |
Menorrhagia | off-label use | 386692008 | |
Heart valve disorder | contraindication | 368009 | DOID:4079 |
Hyperlipoproteinemia | contraindication | 3744001 | DOID:1168 |
Hypocalcemia | contraindication | 5291005 | |
Hypercholesterolemia | contraindication | 13644009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Depressive disorder | contraindication | 35489007 | |
Chloasma | contraindication | 36209000 | |
Migraine | contraindication | 37796009 | DOID:6364 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Body fluid retention | contraindication | 43498006 | |
Thrombosis of retinal vein | contraindication | 46085004 | |
Humoral hypercalcemia of malignancy | contraindication | 47709007 | |
Dementia | contraindication | 52448006 | |
Hepatic porphyria | contraindication | 55056006 | DOID:3133 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Benign mammary dysplasia | contraindication | 57993004 | |
Obstructive hyperbilirubinemia | contraindication | 59848001 | |
Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
Intermenstrual bleeding - irregular | contraindication | 64996003 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Breast lump | contraindication | 89164003 | |
Malignant neoplasm of liver | contraindication | 93870000 | DOID:3571 |
Uterine leiomyoma | contraindication | 95315005 | DOID:13223 |
Deep venous thrombosis | contraindication | 128053003 | |
Endometriosis | contraindication | 129103003 | |
Liver function tests abnormal | contraindication | 166603001 | |
Mammography abnormal | contraindication | 168750009 | |
Angina pectoris | contraindication | 194828000 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Cerebrovascular accident | contraindication | 230690007 | |
Pulmonary thromboembolism | contraindication | 233935004 | |
Thrombophilia | contraindication | 234467004 | DOID:2452 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Cholestasis of pregnancy | contraindication | 235888006 | |
Endometrial carcinoma | contraindication | 254878006 | DOID:2871 |
Chorea | contraindication | 271700006 | |
Pregnancy, function | contraindication | 289908002 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Functional visual loss | contraindication | 313165001 | |
Malignant tumor of cervix | contraindication | 363354003 | DOID:4362 |
Malignant tumor of ovary | contraindication | 363443007 | DOID:2394 |
Thromboembolic disorder | contraindication | 371039008 | |
Cardiovascular event risk | contraindication | 395112001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Estrogen receptor positive tumor | contraindication | 416053008 | |
Porphyria | contraindication | 418470004 | |
Family history of malignant neoplasm of breast | contraindication | 429740004 | |
Hypertensive urgency | contraindication | 443482000 | |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 | |
Nonspecific Abnormal Papanicolaou Smear of Cervix | contraindication | ||
Major Surgery with Prolonged Post-Operative Immobilization | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.93 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Progesterone receptor | Nuclear hormone receptor | AGONIST | WOMBAT-PK | CHEMBL | |||||
Sex hormone-binding globulin | Secreted | Kd | 6.60 | CHEMBL |
ID | Source |
---|---|
4020568 | VUID |
N0000148270 | NUI |
D02367 | KEGG_DRUG |
C0057558 | UMLSCUI |
CHEBI:4453 | CHEBI |
CHEMBL1533 | ChEMBL_ID |
DB00304 | DRUGBANK_ID |
D017135 | MESH_DESCRIPTOR_UI |
40973 | PUBCHEM_CID |
7065 | IUPHAR_LIGAND_ID |
4384 | INN_ID |
81K9V7M3A3 | UNII |
22656 | RXNORM |
4549 | MMSL |
d03780 | MMSL |
003956 | NDDF |
116074007 | SNOMEDCT_US |
126108008 | SNOMEDCT_US |
4020568 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
MERCILON | HUMAN OTC DRUG LABEL | 2 | 72689-0020 | TABLET | 0.15 mg | ORAL | unapproved drug other | 7 sections |