alteplase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5141 105857-23-6

Description:

MoleculeDescription

Synonyms:

  • alteplase
  • activase
  • alteplase (genetical recombination)
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases. Is currently clinical tested as treatment for COVID-19 patients.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.10 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
June 18, 1996 FDA GENENTECH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gingival bleeding 1729.48 27.12 401 11875 14502 90601669
Haemorrhagic transformation stroke 1103.78 27.12 185 12091 1114 90615057
No adverse event 1089.91 27.12 391 11885 67591 90548580
Cerebral haemorrhage 1070.88 27.12 327 11949 34195 90581976
Angioedema 897.82 27.12 335 11941 64541 90551630
Haemorrhage intracranial 691.91 27.12 194 12082 14968 90601203
Off label use 388.07 27.12 597 11679 1101655 89514516
Haemorrhage 323.99 27.12 167 12109 69202 90546969
Death 272.25 27.12 321 11955 456230 90159941
Neurological decompensation 240.77 27.12 62 12214 3439 90612732
Tongue haemorrhage 208.16 27.12 39 12237 472 90615699
Aplastic anaemia 188.34 27.12 70 12206 13199 90602972
Swollen tongue 173.19 27.12 96 12180 45860 90570311
Subarachnoid haemorrhage 161.29 27.12 68 12208 17836 90598335
Cerebral haematoma 155.76 27.12 46 12230 4243 90611928
Cerebral infarction 153.46 27.12 74 12202 26522 90589649
Tongue oedema 149.01 27.12 47 12229 5407 90610764
Brain herniation 130.75 27.12 40 12236 4160 90612011
Mouth haemorrhage 124.86 27.12 46 12230 8455 90607716
NIH stroke scale score increased 118.61 27.12 15 12261 0 90616171
Blood fibrinogen decreased 117.07 27.12 28 12248 1142 90615029
Intraventricular haemorrhage 109.78 27.12 31 12245 2438 90613733
Brain oedema 93.15 27.12 46 12230 17339 90598832
Thrombolysis 90.73 27.12 16 12260 134 90616037
Haemorrhagic cerebral infarction 83.48 27.12 19 12257 622 90615549
NIH stroke scale abnormal 82.19 27.12 11 12265 6 90616165
Hemiparesis 79.41 27.12 51 12225 31768 90584403
Haematoma 79.18 27.12 55 12221 38993 90577178
Brain stem haemorrhage 78.57 27.12 19 12257 812 90615359
Stroke in evolution 76.68 27.12 13 12263 84 90616087
Intracranial mass 75.23 27.12 20 12256 1255 90614916
Respiratory failure 71.31 27.12 84 12192 118334 90497837
Lip swelling 70.47 27.12 51 12225 38559 90577612
Cerebral mass effect 69.02 27.12 18 12258 1048 90615123
Ecchymosis 67.19 27.12 33 12243 12290 90603881
Haemorrhagic infarction 60.88 27.12 13 12263 315 90615856
Subcutaneous haematoma 58.89 27.12 18 12258 1865 90614306
Aphasia 57.21 27.12 47 12229 42765 90573406
Hypotension 57.18 27.12 132 12144 325265 90290906
Cerebral hyperperfusion syndrome 54.15 27.12 8 12268 17 90616154
Cardiogenic shock 53.23 27.12 36 12240 24432 90591739
Coma 51.31 27.12 56 12220 72576 90543595
Haemothorax 50.48 27.12 17 12259 2401 90613770
Reperfusion arrhythmia 47.37 27.12 10 12266 229 90615942
Abdominal discomfort 47.00 27.12 5 12271 477323 90138848
Cardiac arrest 46.61 27.12 64 12212 104871 90511300
Arthralgia 46.20 27.12 24 12252 778498 89837673
Ventricular extrasystoles 45.32 27.12 26 12250 13224 90602947
Ischaemic stroke 44.41 27.12 31 12245 22135 90594036
Diarrhoea 42.43 27.12 39 12237 939151 89677020
Macular hole 42.13 27.12 12 12264 973 90615198
Intra-abdominal haemorrhage 41.29 27.12 15 12261 2647 90613524
Epistaxis 40.98 27.12 54 12222 85071 90531100
Alopecia 40.12 27.12 9 12267 495062 90121109
Extravasation 39.72 27.12 15 12261 2949 90613222
Nasopharyngitis 38.24 27.12 5 12271 407099 90209072
Product quality issue 37.69 27.12 50 12226 79275 90536896
Haemorrhagic stroke 37.22 27.12 18 12258 6478 90609693
Drug interaction 36.82 27.12 101 12175 276352 90339819
Dysarthria 36.73 27.12 41 12235 54441 90561730
Cardiac tamponade 36.54 27.12 17 12259 5615 90610556
Embolism 36.21 27.12 20 12256 9461 90606710
Cerebellar haemorrhage 36.01 27.12 12 12264 1641 90614530
Reocclusion 35.60 27.12 5 12271 6 90616165
Procedural haemorrhage 35.42 27.12 14 12262 3110 90613061
Hydrocephalus 35.26 27.12 17 12259 6077 90610094
Shock 33.12 27.12 29 12247 28749 90587422
Stridor 32.76 27.12 15 12261 4778 90611393
Glossodynia 32.63 27.12 3 12273 321776 90294395
Hepatic enzyme increased 32.54 27.12 5 12271 360731 90255440
Fatigue 32.04 27.12 68 12208 1153955 89462216
Reperfusion injury 31.62 27.12 6 12270 78 90616093
Basal ganglia haemorrhage 31.33 27.12 9 12267 752 90615419
Heparin-induced thrombocytopenia 31.29 27.12 15 12261 5297 90610874
Haemorrhage subcutaneous 30.91 27.12 13 12263 3383 90612788
Catheter site haemorrhage 29.94 27.12 13 12263 3655 90612516
Brain death 28.79 27.12 13 12263 4008 90612163
Retroperitoneal haemorrhage 28.73 27.12 12 12264 3068 90613103
Ventricular tachycardia 28.64 27.12 25 12251 24683 90591488
Weight increased 27.67 27.12 11 12265 417916 90198255

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gingival bleeding 2513.21 20.64 590 15187 7895 42597663
No adverse event 1782.77 20.64 632 15145 38389 42567169
Haemorrhagic transformation stroke 1343.48 20.64 268 15509 1523 42604035
Cerebral haemorrhage 901.60 20.64 386 15391 38580 42566978
Haemorrhage intracranial 716.75 20.64 261 15516 16931 42588627
Angioedema 550.05 20.64 282 15495 42195 42563363
Off label use 541.89 20.64 891 14886 637444 41968114
Neurological decompensation 307.16 20.64 95 15682 3694 42601864
Haemorrhage 254.53 20.64 197 15580 60366 42545192
Tongue haemorrhage 199.62 20.64 48 15729 703 42604855
Ventricular extrasystoles 196.70 20.64 97 15680 13293 42592265
Haemorrhagic infarction 183.96 20.64 42 15735 484 42605074
Mouth haemorrhage 171.02 20.64 70 15707 6191 42599367
NIH stroke scale score increased 139.84 20.64 22 15755 16 42605542
Cerebral infarction 132.09 20.64 102 15675 31067 42574491
Intraventricular haemorrhage 125.42 20.64 49 15728 3835 42601723
Tongue oedema 122.06 20.64 46 15731 3264 42602294
Aplastic anaemia 120.10 20.64 68 15709 12316 42593242
Cerebral haematoma 117.62 20.64 52 15725 5558 42600000
Brain oedema 117.56 20.64 74 15703 16253 42589305
Brain stem haemorrhage 114.97 20.64 33 15744 986 42604572
Ventricular tachycardia 111.30 20.64 91 15686 30069 42575489
Subarachnoid haemorrhage 102.71 20.64 65 15712 14407 42591151
Haematoma 102.24 20.64 84 15693 27939 42577619
Death 101.39 20.64 392 15385 470793 42134765
Hemiparesis 98.91 20.64 68 15709 17308 42588250
Brain herniation 98.84 20.64 44 15733 4779 42600779
Blood fibrinogen decreased 92.26 20.64 31 15746 1572 42603986
Swollen tongue 88.88 20.64 69 15708 21162 42584396
Stroke in evolution 84.90 20.64 15 15762 37 42605521
Chest pain 82.24 20.64 168 15609 139362 42466196
Haemorrhagic cerebral infarction 79.24 20.64 24 15753 867 42604691
Reperfusion arrhythmia 74.67 20.64 15 15762 88 42605470
Haemorrhagic stroke 72.72 20.64 41 15736 7361 42598197
Ischaemic stroke 69.51 20.64 61 15716 22172 42583386
Thrombolysis 67.94 20.64 14 15763 95 42605463
Cerebral artery occlusion 63.60 20.64 20 15757 820 42604738
Aphasia 63.40 20.64 60 15717 24023 42581535
Cerebral mass effect 62.04 20.64 22 15755 1312 42604246
Diarrhoea 60.94 20.64 49 15728 460800 42144758
Toxicity to various agents 60.55 20.64 7 15770 229129 42376429
Cerebral hyperperfusion syndrome 57.91 20.64 12 15765 84 42605474
Hemiplegia 57.42 20.64 36 15741 7843 42597715
Extrasystoles 57.37 20.64 29 15748 4180 42601378
Dysphoria 49.50 20.64 23 15754 2757 42602801
Coma 48.78 20.64 78 15699 53476 42552082
Fatigue 48.55 20.64 54 15723 435587 42169971
Basal ganglia haemorrhage 47.35 20.64 17 15760 1051 42604507
Electrocardiogram ST segment elevation 42.94 20.64 27 15750 5912 42599646
Fall 40.64 20.64 18 15759 234502 42371056
Bradycardia 40.11 20.64 94 15683 85390 42520168
Cardiac arrest 38.63 20.64 108 15669 109212 42496346
Product closure issue 38.35 20.64 6 15771 4 42605554
Hypotension 37.32 20.64 191 15586 257440 42348118
Coagulopathy 36.48 20.64 43 15734 22119 42583439
Intracranial pressure increased 35.69 20.64 22 15755 4652 42600906
Cardiac ventricular thrombosis 35.35 20.64 16 15761 1806 42603752
Reocclusion 34.19 20.64 6 15771 14 42605544
Extravasation blood 33.40 20.64 8 15769 115 42605443
Product quality issue 33.32 20.64 37 15740 17845 42587713
Epistaxis 33.01 20.64 75 15702 66751 42538807
Aortic dissection 32.86 20.64 18 15759 3054 42602504
Malaise 32.68 20.64 19 15758 212137 42393421
NIH stroke scale abnormal 32.16 20.64 5 15772 3 42605555
Haematuria 32.10 20.64 68 15709 57731 42547827
Paresis 30.56 20.64 16 15761 2480 42603078
Reperfusion injury 30.39 20.64 7 15770 84 42605474
Decreased appetite 30.17 20.64 17 15760 193120 42412438
Lip swelling 29.76 20.64 36 15741 19017 42586541
Weight decreased 28.80 20.64 21 15756 207927 42397631
Haemothorax 28.63 20.64 20 15757 5216 42600342
Central nervous system haemorrhage 28.18 20.64 7 15770 118 42605440
Catheter site haemorrhage 27.45 20.64 15 15762 2533 42603025
Haemorrhage subcutaneous 26.92 20.64 15 15762 2631 42602927
Neutropenia 26.51 20.64 21 15756 199410 42406148
Intentional product use issue 26.38 20.64 72 15705 71761 42533797
Ventricular fibrillation 26.22 20.64 43 15734 30080 42575478
Laryngeal oedema 25.95 20.64 17 15760 3991 42601567
Constipation 25.75 20.64 14 15763 162277 42443281
Embolism 25.31 20.64 23 15754 8740 42596818
Puncture site haemorrhage 25.12 20.64 8 15769 342 42605216
Rhythm idioventricular 25.05 20.64 8 15769 345 42605213
Product dose omission issue 24.96 20.64 13 15764 154352 42451206
Parotid gland haemorrhage 24.79 20.64 5 15772 30 42605528
Shock 24.58 20.64 41 15736 29080 42576478
Arthralgia 24.40 20.64 24 15753 205214 42400344
Bullous haemorrhagic dermatosis 24.39 20.64 6 15771 97 42605461
Myocardial rupture 24.29 20.64 7 15770 212 42605346
Thrombectomy 24.22 20.64 6 15771 100 42605458
Hydrocephalus 23.80 20.64 19 15758 6059 42599499
Product use in unapproved indication 23.80 20.64 20 15757 184436 42421122
Cerebral ischaemia 23.58 20.64 20 15757 6939 42598619
Anaemia 22.99 20.64 43 15734 280235 42325323
Extravasation 22.83 20.64 13 15764 2377 42603181
Dehydration 22.82 20.64 12 15765 141755 42463803
Cerebral reperfusion injury 22.60 20.64 4 15773 10 42605548
Hyponatraemia 22.51 20.64 5 15772 101457 42504101
Disease progression 21.92 20.64 13 15764 143643 42461915
Depression 21.85 20.64 7 15770 111356 42494202
Hyperhidrosis 21.48 20.64 78 15699 90434 42515124
Paralysis 21.41 20.64 19 15758 7001 42598557
Vitreous haemorrhage 21.15 20.64 13 15764 2734 42602824
Lip haemorrhage 20.81 20.64 9 15768 911 42604647
Weight increased 20.81 20.64 7 15770 107976 42497582
Factor I deficiency 20.71 20.64 3 15774 0 42605558
NIH stroke scale score decreased 20.71 20.64 3 15774 0 42605558
Hemianopia 20.70 20.64 9 15768 923 42604635

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gingival bleeding 4311.87 21.95 976 23756 18863 110545704
No adverse event 2876.89 21.95 936 23796 72903 110491664
Haemorrhagic transformation stroke 2270.76 21.95 418 24314 2619 110561948
Cerebral haemorrhage 1873.96 21.95 658 24074 64310 110500257
Angioedema 1260.35 21.95 554 24178 97946 110466621
Haemorrhage intracranial 1221.67 21.95 391 24341 28578 110535989
Off label use 963.54 21.95 1403 23329 1498782 109065785
Haemorrhage 467.16 21.95 293 24439 106399 110458168
Tongue haemorrhage 404.50 21.95 85 24647 1120 110563447
Cerebral haematoma 332.93 21.95 112 24620 9520 110555047
Cerebral infarction 304.02 21.95 172 24560 51666 110512901
Mouth haemorrhage 303.33 21.95 114 24618 13374 110551193
Aplastic anaemia 301.21 21.95 134 24598 24174 110540393
Neurological decompensation 281.94 21.95 91 24641 6792 110557775
Subarachnoid haemorrhage 257.63 21.95 128 24604 29574 110534993
NIH stroke scale score increased 255.55 21.95 37 24695 24 110564543
Tongue oedema 246.33 21.95 86 24646 8170 110556397
Brain herniation 240.36 21.95 86 24646 8777 110555790
Swollen tongue 227.49 21.95 151 24581 60211 110504356
Intraventricular haemorrhage 210.11 21.95 69 24663 5438 110559129
Brain oedema 209.22 21.95 113 24619 30985 110533582
Haemorrhagic cerebral infarction 200.77 21.95 50 24682 1445 110563122
Death 200.23 21.95 465 24267 698404 109866163
Brain stem haemorrhage 190.84 21.95 50 24682 1776 110562791
Blood fibrinogen decreased 189.81 21.95 54 24678 2621 110561946
Haematoma 168.25 21.95 124 24608 58352 110506215
Hemiparesis 163.39 21.95 109 24623 43794 110520773
Stroke in evolution 155.75 21.95 27 24705 112 110564455
Cerebral mass effect 154.53 21.95 45 24687 2374 110562193
Thrombolysis 148.17 21.95 29 24703 260 110564307
Haemorrhagic infarction 146.20 21.95 35 24697 854 110563713
Aphasia 117.92 21.95 101 24631 58896 110505671
NIH stroke scale abnormal 111.36 21.95 16 24716 9 110564558
Cerebral hyperperfusion syndrome 110.87 21.95 20 24712 109 110564458
Haemorrhagic stroke 100.87 21.95 53 24679 13736 110550831
Fatigue 98.55 21.95 77 24655 1215881 109348686
Ventricular extrasystoles 95.95 21.95 61 24671 22580 110541987
Diarrhoea 88.76 21.95 75 24657 1139430 109425137
Coma 88.42 21.95 120 24612 117749 110446818
Intracranial mass 87.39 21.95 29 24703 2359 110562208
Cardiac arrest 84.43 21.95 155 24577 196598 110367969
Lip swelling 81.97 21.95 77 24655 50590 110513977
Arthralgia 81.95 21.95 36 24696 779596 109784971
Joint swelling 79.29 21.95 5 24727 442840 110121727
Ischaemic stroke 79.12 21.95 69 24663 41194 110523373
Toxicity to various agents 78.89 21.95 8 24724 480547 110084020
Haemothorax 78.31 21.95 36 24696 6995 110557572
Epistaxis 77.69 21.95 119 24613 130253 110434314
Ventricular tachycardia 77.09 21.95 74 24658 49935 110514632
Cerebral artery occlusion 76.29 21.95 25 24707 1955 110562612
Nasopharyngitis 75.20 21.95 3 24729 394358 110170209
Respiratory failure 74.58 21.95 155 24577 215177 110349390
Hemiplegia 73.94 21.95 52 24680 22730 110541837
Basal ganglia haemorrhage 73.40 21.95 24 24708 1864 110562703
Ecchymosis 71.69 21.95 46 24686 17292 110547275
Coagulopathy 69.70 21.95 64 24668 40847 110523720
Subcutaneous haematoma 69.47 21.95 26 24706 3010 110561557
Drug intolerance 66.11 21.95 7 24725 406505 110158062
Dysphoria 65.66 21.95 31 24701 6397 110558170
Reperfusion arrhythmia 65.54 21.95 15 24717 299 110564268
Malaise 64.52 21.95 35 24697 671784 109892783
Pain 63.69 21.95 72 24660 954883 109609684
Aortic dissection 63.67 21.95 28 24704 4905 110559662
Hydrocephalus 62.32 21.95 35 24697 10340 110554227
Embolism 61.92 21.95 41 24691 16248 110548319
Haemorrhage subcutaneous 60.56 21.95 28 24704 5511 110559056
Reperfusion injury 59.79 21.95 13 24719 203 110564364
Alopecia 57.50 21.95 7 24725 364746 110199821
Hypotension 57.01 21.95 250 24482 523599 110040968
Abdominal discomfort 56.45 21.95 10 24722 393848 110170719
Fall 54.30 21.95 34 24698 603448 109961119
Weight increased 53.34 21.95 14 24718 419630 110144937
Product closure issue 52.76 21.95 8 24724 10 110564557
Intra-abdominal haemorrhage 52.23 21.95 25 24707 5317 110559250
Shock 51.93 21.95 62 24670 53526 110511041
Musculoskeletal stiffness 50.54 21.95 3 24729 279819 110284748
Product quality issue 49.51 21.95 73 24659 77226 110487341
Vitreous haemorrhage 49.41 21.95 23 24709 4597 110559970
Dysarthria 48.99 21.95 76 24656 84045 110480522
Intracranial pressure increased 48.70 21.95 30 24702 10505 110554062
Cardiogenic shock 48.58 21.95 62 24670 57276 110507291
Hepatic enzyme increased 48.56 21.95 7 24725 320885 110243682
Depression 47.84 21.95 7 24725 317328 110247239
Haematuria 46.96 21.95 74 24658 82931 110481636
Cerebellar haemorrhage 46.91 21.95 20 24712 3251 110561316
Cardiac tamponade 46.75 21.95 30 24702 11277 110553290
Hypofibrinogenaemia 45.01 21.95 18 24714 2489 110562078
Catheter site haemorrhage 44.14 21.95 23 24709 5857 110558710
Pericardial haemorrhage 43.79 21.95 22 24710 5195 110559372
Laryngeal oedema 42.99 21.95 27 24705 9780 110554787
Gastrointestinal disorder 42.49 21.95 3 24729 241949 110322618
Weight decreased 41.21 21.95 27 24705 468030 110096537
Insomnia 40.50 21.95 15 24717 360575 110203992
Myocardial rupture 40.35 21.95 10 24722 283 110564284
Haematemesis 39.56 21.95 57 24675 59051 110505516
Treatment delayed 39.44 21.95 11 24721 496 110564071
Heparin-induced thrombocytopenia 39.23 21.95 27 24705 11397 110553170
Brain death 39.01 21.95 22 24710 6551 110558016
Asthma 38.95 21.95 5 24727 250286 110314281
Mobility decreased 38.80 21.95 4 24728 237418 110327149
Lip oedema 38.63 21.95 23 24709 7577 110556990
Glossodynia 38.27 21.95 3 24729 222001 110342566
Thrombectomy 37.82 21.95 10 24722 368 110564199
Facial paralysis 37.63 21.95 36 24696 24178 110540389
Decreased appetite 37.30 21.95 31 24701 475815 110088752
Anaphylactic reaction 36.90 21.95 80 24652 114220 110450347
Abdominal pain upper 36.79 21.95 16 24716 349095 110215472
Extravasation 36.51 21.95 19 24713 4826 110559741
Product use in unapproved indication 36.50 21.95 28 24704 447349 110117218
Pulseless electrical activity 36.17 21.95 30 24702 16727 110547840
Embolic stroke 35.66 21.95 23 24709 8720 110555847
Cytokine release syndrome 34.78 21.95 59 24673 70247 110494320
Peripheral swelling 34.63 21.95 24 24708 404010 110160557
Procedural haemorrhage 34.49 21.95 19 24713 5408 110559159
Respiratory distress 34.34 21.95 58 24674 68816 110495751
Cerebral artery embolism 33.92 21.95 14 24718 2098 110562469
Sinusitis 33.89 21.95 12 24720 296676 110267891
Product dose omission issue 33.51 21.95 15 24717 321767 110242800
Sleep disorder 33.37 21.95 3 24729 198641 110365926
Cerebral reperfusion injury 33.06 21.95 6 24726 34 110564533
Compartment syndrome 32.97 21.95 19 24713 5891 110558676
Hemianopia 32.93 21.95 15 24717 2853 110561714
Stridor 32.80 21.95 20 24712 6875 110557692
Retroperitoneal haemorrhage 32.52 21.95 19 24713 6046 110558521
Inflammation 32.25 21.95 3 24729 193235 110371332
Macular hole 31.75 21.95 11 24721 1020 110563547
Cardiac ventricular thrombosis 31.60 21.95 15 24717 3132 110561435
Tongue haematoma 31.36 21.95 8 24724 255 110564312
Central nervous system haemorrhage 31.33 21.95 9 24723 452 110564115
Reocclusion 31.22 21.95 5 24727 11 110564556
Paresis 30.89 21.95 17 24715 4827 110559740
Drug hypersensitivity 30.44 21.95 34 24698 454056 110110511
Pericarditis 30.44 21.95 6 24726 219108 110345459
Impaired healing 30.44 21.95 4 24728 196713 110367854
Pain in extremity 29.98 21.95 39 24693 487079 110077488
Endotracheal intubation 29.69 21.95 18 24714 6126 110558441
Carotid artery occlusion 29.11 21.95 21 24711 9544 110555023
Myalgia 29.05 21.95 7 24725 222374 110342193
Bradycardia 28.53 21.95 88 24644 155429 110409138
Lip haemorrhage 28.08 21.95 11 24721 1441 110563126
Blood pressure decreased 27.85 21.95 72 24660 115019 110449548
Electrocardiogram ST segment elevation 27.63 21.95 20 24712 9140 110555427
Osteoarthritis 27.58 21.95 4 24728 182619 110381948
Asthenia 27.44 21.95 72 24660 688927 109875640
Therapeutic product effect incomplete 27.42 21.95 8 24724 223797 110340770
Completed suicide 27.34 21.95 10 24722 242371 110322196
Swelling 27.33 21.95 23 24709 351018 110213549
Infusion related reaction 27.27 21.95 27 24705 381135 110183432
Influenza 27.24 21.95 3 24729 169098 110395469
Parotid gland haemorrhage 27.17 21.95 5 24727 31 110564536
Cerebral ischaemia 26.81 21.95 22 24710 12082 110552485
Pharyngeal oedema 26.62 21.95 25 24707 16403 110548164
Peripheral artery occlusion 26.60 21.95 13 24719 2892 110561675
Extravasation blood 26.07 21.95 8 24724 505 110564062
Upper gastrointestinal haemorrhage 26.06 21.95 43 24689 50053 110514514
Constipation 25.99 21.95 25 24707 357761 110206806
Depressed level of consciousness 25.90 21.95 69 24663 112209 110452358
Discomfort 25.71 21.95 8 24724 214699 110349868
Rash 25.51 21.95 96 24636 820868 109743699
Migraine 25.37 21.95 4 24728 171648 110392919
Hypoxia 25.36 21.95 75 24657 129440 110435127
Lividity 24.70 21.95 8 24724 603 110563964
Retroperitoneal haematoma 24.69 21.95 16 24716 6115 110558452
Intracardiac thrombus 24.56 21.95 14 24718 4254 110560313
Muscle spasms 24.52 21.95 16 24716 278141 110286426
Therapeutic product effect decreased 24.49 21.95 12 24720 244304 110320263
Injury 24.32 21.95 5 24727 177260 110387307
Haemoperitoneum 24.03 21.95 15 24717 5373 110559194
Paralysis 23.87 21.95 23 24709 15577 110548990
Dizziness 23.44 21.95 79 24653 698114 109866453
Puncture site haemorrhage 23.28 21.95 8 24724 724 110563843
Cerebral artery thrombosis 23.26 21.95 10 24722 1658 110562909
Gait disturbance 23.20 21.95 17 24715 278191 110286376
Vascular access site haematoma 22.81 21.95 4 24728 18 110564549
Extrasystoles 22.48 21.95 17 24715 8301 110556266
Quadriplegia 22.31 21.95 13 24719 4114 110560453
Infection 22.27 21.95 29 24703 362171 110202396
Peripheral ischaemia 22.22 21.95 19 24713 11039 110553528
NIH stroke scale score decreased 22.22 21.95 3 24729 0 110564567
Factor I deficiency 22.22 21.95 3 24729 0 110564567
Mucosal inflammation 22.09 21.95 59 24673 96082 110468485

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AD02 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Enzymes
ATC S01XA13 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

B01AD Enzymes 4 drugs
cinaxadamtase alfareteplasetenecteplaseurokinase
S01XA Other ophthalmologicals 24 drugs
acetylcysteinealumascorbic acidavacincaptad pegolcenegerminciclosporindexpanthenoldiquafosolethylmorphineguaiazulenheparininosine show all 24 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute myocardial infarction indication 57054005 DOID:9408
Pulmonary embolism indication 59282003 DOID:9477
Ischemic stroke indication 422504002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Plasminogen Enzyme ACTIVATOR DRUG LABEL DRUG LABEL

External reference:

IDSource
1RXS4UE564 UNII
4019319 VANDF
4019599 VANDF
C0032143 UMLSCUI
CHEBI:749459 CHEBI
CHEMBL1201593 ChEMBL_ID
D02837 KEGG_DRUG
DB00009 DRUGBANK_ID
5975 INN_ID
204210 RXNORM
4155 MMSL
970 MMSL
d00521 MMSL
002074 NDDF
108997009 SNOMEDCT_US
27638005 SNOMEDCT_US
37411004 SNOMEDCT_US
387152000 SNOMEDCT_US
D010959 MESH_DESCRIPTOR_UI
1RXS4UE564 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cathflo Activase HUMAN PRESCRIPTION DRUG LABEL 1 50242-041 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2.20 mg INTRAVENOUS BLA 21 sections