reteplase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5044 133652-38-7

Description:

MoleculeDescription

Synonyms:

  • rapilysin
  • reteplase
  • retavase
mutant form of tissue plasminogen activator used in treatment of myocardial infarct
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
20 U P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1996 FDA EKR THERAP

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AD07 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Enzymes
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute myocardial infarction indication 57054005 DOID:9408




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Plasminogen Enzyme ACTIVATOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
DQA630RIE9 UNII
D05721 KEGG_DRUG
4024038 VUID
N0000148458 NUI
4020988 VANDF
4024038 VANDF
C0256103 UMLSCUI
CHEMBL2107885 ChEMBL_ID
DB00015 DRUGBANK_ID
7102 INN_ID
C087896 MESH_SUPPLEMENTAL_RECORD_UI
5526 PUBCHEM_CID
219642 RXNORM
5420 MMSL
6501 MMSL
d04067 MMSL
108998004 SNOMEDCT_US
386957002 SNOMEDCT_US
006349 NDDF

Pharmaceutical products:

None