All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

tenecteplase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5066	191588-94-0

Description:

Molecule	Description
Synonyms: tenecteplase metalyse tnkase	A tissue plasminogen activator enzyme that acts as a fibrinolytic agent; it is used for the dissolution of blood clots, such as those that occur in acute MYOCARDIAL INFARCTION. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
40	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 2, 2000	FDA	GENENTECH
Feb. 23, 2001	EMA	BOEHRINGER INGELHEIM INTERNATIONAL GMBH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral haemorrhage	249.78	79.88	61	957	34461	90592968
Haemorrhage intracranial	212.76	79.88	46	972	15116	90612313
Angioedema	193.81	79.88	57	961	64819	90562610
Haemorrhagic transformation stroke	117.46	79.88	19	999	1280	90626149
Off label use	85.92	79.88	81	937	1102171	89525258
Subarachnoid haemorrhage	81.73	79.88	22	996	17882	90609547

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral haemorrhage	217.13	60.59	69	1178	38897	42581191
No adverse event	148.77	60.59	52	1195	38969	42581119
Haemorrhage intracranial	136.18	60.59	40	1207	17152	42602936
Haemorrhagic transformation stroke	135.71	60.59	26	1221	1765	42618323
Angioedema	129.52	60.59	48	1199	42429	42577659
Off label use	110.94	60.59	112	1135	638223	41981865
Subarachnoid haemorrhage	77.62	60.59	25	1222	14447	42605641

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cerebral haemorrhage	428.52	58.86	121	2158	64847	110522173
Angioedema	309.74	58.86	104	2175	98396	110488624
Haemorrhage intracranial	303.99	58.86	78	2201	28891	110558129
Haemorrhagic transformation stroke	199.50	58.86	37	2242	3000	110584020
No adverse event	173.93	58.86	63	2216	73776	110513244
Off label use	156.85	58.86	171	2108	1500014	109087006
Subarachnoid haemorrhage	149.44	58.86	45	2234	29657	110557363
Neurological decompensation	109.78	58.86	26	2253	6857	110580163
Cerebral infarction	84.96	58.86	34	2245	51804	110535216
Stroke in evolution	79.82	58.86	11	2268	128	110586892
Haemorrhage	72.77	58.86	38	2241	106654	110480366
Cerebral haematoma	67.94	58.86	19	2260	9613	110577407
Pericardial haemorrhage	64.21	58.86	16	2263	5201	110581819
Intraventricular haemorrhage	63.35	58.86	16	2263	5491	110581529
Hemiparesis	59.01	58.86	25	2254	43878	110543142

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B01AD11	BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Enzymes
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D005343	Fibrinolytic Agents
MeSH PA	D006401	Hematologic Agents
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:50249	anticoagulant

Related Drugs by ATC class:

B01AD Enzymes 4 drugs

alteplasecinaxadamtase alfareteplaseurokinase

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ankylosing spondylitis	indication	9631008	DOID:7147
Acute myocardial infarction	indication	57054005	DOID:9408

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Plasminogen	Enzyme	P00747	PLMN_HUMAN	ACTIVATOR				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
WGD229O42W	UNII
D06070	KEGG_DRUG
4021222	VANDF
C0872913	UMLSCUI
CHEBI:753718	CHEBI
CHEMBL2108791	ChEMBL_ID
DB00031	DRUGBANK_ID
D000077785	MESH_DESCRIPTOR_UI
7769	INN_ID
259280	RXNORM
15637	MMSL
37705	MMSL
d04694	MMSL
008304	NDDF
127967007	SNOMEDCT_US
387066007	SNOMEDCT_US

Pharmaceutical products:

None