cinaxadamtase alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5851 None

Description:

MoleculeDescription

Molfile

Synonyms:

  • cinaxadamtase alfa
  • apadamtase alfa
  • adzynma
  • radamts13
Adzynma is approved for the treatment of ADAMTS13 deficiency in adults and children with congenital thrombotic thrombocytopenic purpura (cTTP). Adzynma contains the active ingredient apadamtase alfa/cinaxadamtase alfa. rADAMTS13, the active substance, is a recombinant form of the endogenous ADAMTS13. ADAMTS13 is a plasma zinc metalloprotease that regulates the activity of von Willebrand factor (VWF) by cleaving large and ultra-large VWF multimers to smaller units and thereby reducing the platelet binding properties of VWF and its propensity to form microthrombi. rADAMTS13 is expected to reduce or eliminate the spontaneous formation of VWF-platelet microthrombi that leads to platelet consumption and thrombocytopenia in patients with cTTP.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
200 U P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 1, 2024 EMA Takeda Manufacturing Austria AG

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AD13 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Enzymes
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

B01AD Enzymes 4 drugs
alteplasereteplasetenecteplaseurokinase

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Thrombotic thrombocytopenic purpura indication 78129009 DOID:10772




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
von Willebrand factor Secreted OTHER UNKNOWN DRUG LABEL

External reference:

IDSource
DB15164 DRUGBANK_ID
C5669630 UMLSCUI
CHEMBL5095472 ChEMBL_ID
CHEMBL4594607 ChEMBL_ID
2406308-29-8 SECONDARY_CAS_RN
2086325-24-6 SECONDARY_CAS_RN
11803 INN_ID
10765 INN_ID
2670285 RXNORM
1366579000 SNOMEDCT_US
1380115007 SNOMEDCT_US
1380117004 SNOMEDCT_US
D12570 KEGG_DRUG
R765VT7PWP UNII
375207 MMSL
42236 MMSL
d10146 MMSL
CHEBI:759033 CHEBI

Pharmaceutical products:

None