urokinase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5109 9039-53-6

Description:

MoleculeDescription

Synonyms:

  • urokinase
  • kinlytic
  • abbokinase
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 MU P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peliosis hepatis 53.59 48.03 6 172 65 42621092

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Peliosis hepatis 59.83 46.77 7 277 190 110588825

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AD04 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Enzymes
FDA PE N0000009695 Increased Thrombolysis
FDA EPC N0000175526 Thrombolytic Agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:50249 anticoagulant

Related Drugs by ATC class:

B01AD Enzymes 4 drugs
alteplasecinaxadamtase alfareteplasetenecteplase

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pulmonary embolism indication 59282003 DOID:9477




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Plasminogen Enzyme ACTIVATOR DRUG LABEL DRUG LABEL

External reference:

IDSource
83G67E21XI UNII
D03341 KEGG_DRUG
4018727 VANDF
C0042071 UMLSCUI
CHEBI:749515 CHEBI
CHEMBL1201420 ChEMBL_ID
DB00013 DRUGBANK_ID
2053 INN_ID
11055 RXNORM
133054 MMSL
17 MMSL
5658 MMSL
d00523 MMSL
002076 NDDF
319826005 SNOMEDCT_US
59082006 SNOMEDCT_US
D014568 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None