normethadone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1969	467-85-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

normethadone
desmethylmethadone
mepidon
noramidone
normedon
phenyldimazone

Molecular weight: 295.43
Formula: C20H25NO
CLOGP: 3.86
LIPINSKI: 0
HAC: 2
HDO: 0
TPSA: 20.31
ALOGS: -4.60
ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R05DA06	RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives
MeSH PA	D000700	Analgesics
MeSH PA	D000701	Analgesics, Opioid
MeSH PA	D000996	Antitussive Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D009294	Narcotics
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.4	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	7.45		CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	4.46		CHEMBL
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	5.37		CHEMBL

External reference:

ID	Source
D07384	KEGG_DRUG
111750-68-6	SECONDARY_CAS_RN
C0069008	UMLSCUI
CHEBI:135242	CHEBI
CHEMBL346331	ChEMBL_ID
DB11609	DRUGBANK_ID
C005845	MESH_SUPPLEMENTAL_RECORD_UI
10090	PUBCHEM_CID
467	INN_ID
KR2L2A68XL	UNII
32009	RXNORM
004624	NDDF

Pharmaceutical products:

None