Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor antagonists/agonists, morphinan derivates | 842 | 125-71-3 |
Dose | Unit | Route |
---|---|---|
40 | mg | O |
90 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 15 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.19 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.88 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 11 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 3, 1957 | FDA | ANI PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2578.03 | 9.64 | 3586 | 308365 | 134615 | 52902500 |
Toxicity to various agents | 2088.17 | 9.64 | 4211 | 307740 | 215387 | 52821728 |
Infusion related reaction | 785.98 | 9.64 | 2346 | 309605 | 153611 | 52883504 |
Sinusitis | 603.65 | 9.64 | 2260 | 309691 | 166304 | 52870811 |
Acute hepatic failure | 462.23 | 9.64 | 529 | 311422 | 16191 | 53020924 |
Overdose | 453.59 | 9.64 | 1524 | 310427 | 106212 | 52930903 |
Muscle injury | 443.14 | 9.64 | 696 | 311255 | 29070 | 53008045 |
Folliculitis | 439.95 | 9.64 | 718 | 311233 | 30991 | 53006124 |
Intentional product misuse | 361.19 | 9.64 | 854 | 311097 | 48538 | 52988577 |
Irritable bowel syndrome | 358.49 | 9.64 | 790 | 311161 | 42842 | 52994273 |
Blood pressure fluctuation | 317.54 | 9.64 | 665 | 311286 | 34805 | 53002310 |
Lower respiratory tract infection | 317.04 | 9.64 | 1210 | 310741 | 89771 | 52947344 |
Ill-defined disorder | 301.72 | 9.64 | 798 | 311153 | 48646 | 52988469 |
Metabolic acidosis | 294.45 | 9.64 | 717 | 311234 | 41525 | 52995590 |
Sleep disorder due to general medical condition, insomnia type | 268.14 | 9.64 | 498 | 311453 | 23851 | 53013264 |
Joint swelling | 262.17 | 9.64 | 2301 | 309650 | 232337 | 52804778 |
Blister | 248.18 | 9.64 | 1015 | 310936 | 77738 | 52959377 |
Anti-cyclic citrullinated peptide antibody positive | 241.50 | 9.64 | 810 | 311141 | 56362 | 52980753 |
Exposure to toxic agent | 240.05 | 9.64 | 145 | 311806 | 1735 | 53035380 |
Nasopharyngitis | 235.45 | 9.64 | 1925 | 310026 | 190370 | 52846745 |
Injection site pain | 232.20 | 9.64 | 193 | 311758 | 113198 | 52923917 |
Hepatotoxicity | 230.33 | 9.64 | 506 | 311445 | 27374 | 53009741 |
Duodenal ulcer perforation | 229.19 | 9.64 | 582 | 311369 | 34601 | 53002514 |
Intentional overdose | 226.04 | 9.64 | 884 | 311067 | 66321 | 52970794 |
Helicobacter infection | 223.72 | 9.64 | 616 | 311335 | 38453 | 52998662 |
Product dose omission issue | 221.71 | 9.64 | 495 | 311456 | 191125 | 52845990 |
Impaired healing | 213.87 | 9.64 | 842 | 311109 | 63363 | 52973752 |
Hepatic enzyme increased | 207.62 | 9.64 | 1356 | 310595 | 124839 | 52912276 |
Anion gap | 205.70 | 9.64 | 111 | 311840 | 1053 | 53036062 |
Pericarditis | 205.21 | 9.64 | 833 | 311118 | 63573 | 52973542 |
Therapeutic product effect decreased | 185.12 | 9.64 | 1314 | 310637 | 124341 | 52912774 |
Respiratory arrest | 181.39 | 9.64 | 518 | 311433 | 33022 | 53004093 |
Psoriasis | 172.46 | 9.64 | 153 | 311798 | 86936 | 52950179 |
Body temperature increased | 160.62 | 9.64 | 489 | 311462 | 32310 | 53004805 |
Cardio-respiratory arrest | 157.97 | 9.64 | 722 | 311229 | 58036 | 52979079 |
Gastrointestinal disorder | 149.10 | 9.64 | 969 | 310982 | 89035 | 52948080 |
Intentional product use issue | 147.85 | 9.64 | 824 | 311127 | 71670 | 52965445 |
Diarrhoea | 139.54 | 9.64 | 2700 | 309251 | 622846 | 52414269 |
Depressed level of consciousness | 136.20 | 9.64 | 655 | 311296 | 53773 | 52983342 |
Synovitis | 134.51 | 9.64 | 1085 | 310866 | 106808 | 52930307 |
Device expulsion | 132.98 | 9.64 | 11 | 311940 | 29802 | 53007313 |
Hypersensitivity | 132.37 | 9.64 | 1844 | 310107 | 208821 | 52828294 |
Coagulopathy | 128.42 | 9.64 | 326 | 311625 | 19372 | 53017743 |
Heart rate decreased | 128.26 | 9.64 | 491 | 311460 | 36456 | 53000659 |
Hand deformity | 127.06 | 9.64 | 891 | 311060 | 83958 | 52953157 |
Weight increased | 125.05 | 9.64 | 1782 | 310169 | 202785 | 52834330 |
Peripheral swelling | 124.23 | 9.64 | 1791 | 310160 | 204317 | 52832798 |
Injection site erythema | 122.70 | 9.64 | 163 | 311788 | 77086 | 52960029 |
Swelling | 122.15 | 9.64 | 1678 | 310273 | 189427 | 52847688 |
Stomatitis | 114.79 | 9.64 | 973 | 310978 | 97185 | 52939930 |
Drug abuse | 113.76 | 9.64 | 714 | 311237 | 64812 | 52972303 |
Ear pain | 111.90 | 9.64 | 405 | 311546 | 29268 | 53007847 |
Sedation complication | 108.61 | 9.64 | 169 | 311782 | 6997 | 53030118 |
Wrong technique in product usage process | 105.57 | 9.64 | 117 | 311834 | 59915 | 52977200 |
Medication error | 105.38 | 9.64 | 457 | 311494 | 35908 | 53001207 |
Blood pressure diastolic abnormal | 105.34 | 9.64 | 186 | 311765 | 8559 | 53028556 |
Poisoning | 105.03 | 9.64 | 243 | 311708 | 13607 | 53023508 |
Wound | 104.65 | 9.64 | 903 | 311048 | 90654 | 52946461 |
Discomfort | 103.12 | 9.64 | 930 | 311021 | 94542 | 52942573 |
Injection site reaction | 102.35 | 9.64 | 89 | 311862 | 51077 | 52986038 |
Infusion site pain | 101.41 | 9.64 | 218 | 311733 | 11615 | 53025500 |
Analgesic drug level increased | 98.93 | 9.64 | 83 | 311868 | 1717 | 53035398 |
Anaemia | 93.99 | 9.64 | 1100 | 310851 | 275618 | 52761497 |
Muscle spasticity | 91.15 | 9.64 | 270 | 311681 | 17568 | 53019547 |
Hepatic failure | 90.36 | 9.64 | 432 | 311519 | 35374 | 53001741 |
Acute lung injury | 87.90 | 9.64 | 71 | 311880 | 1390 | 53035725 |
Infusion site swelling | 85.18 | 9.64 | 149 | 311802 | 6805 | 53030310 |
Hepatic necrosis | 84.91 | 9.64 | 134 | 311817 | 5616 | 53031499 |
Creatinine renal clearance decreased | 84.23 | 9.64 | 190 | 311761 | 10461 | 53026654 |
Injection site pruritus | 83.60 | 9.64 | 72 | 311879 | 41517 | 52995598 |
Exposure via ingestion | 83.29 | 9.64 | 99 | 311852 | 3156 | 53033959 |
Blood pressure increased | 83.08 | 9.64 | 1217 | 310734 | 139262 | 52897853 |
Neutropenia | 82.96 | 9.64 | 567 | 311384 | 158618 | 52878497 |
Oxygen saturation decreased | 82.13 | 9.64 | 746 | 311205 | 75979 | 52961136 |
Rheumatoid factor positive | 80.48 | 9.64 | 463 | 311488 | 40735 | 52996380 |
Respiratory depression | 80.43 | 9.64 | 209 | 311742 | 12597 | 53024518 |
Blood pressure diastolic decreased | 79.91 | 9.64 | 248 | 311703 | 16555 | 53020560 |
Blood pressure systolic abnormal | 79.82 | 9.64 | 147 | 311804 | 6992 | 53030123 |
Injection site bruising | 79.61 | 9.64 | 62 | 311889 | 37584 | 52999531 |
Sopor | 76.71 | 9.64 | 15 | 311936 | 21069 | 53016046 |
Disease progression | 76.47 | 9.64 | 321 | 311630 | 101599 | 52935516 |
Osteonecrosis of jaw | 74.59 | 9.64 | 61 | 311890 | 36085 | 53001030 |
Infection | 73.95 | 9.64 | 1416 | 310535 | 170789 | 52866326 |
Hepatic cytolysis | 71.90 | 9.64 | 149 | 311802 | 7736 | 53029379 |
Pruritus | 71.37 | 9.64 | 2235 | 309716 | 291597 | 52745518 |
Drug resistance | 70.97 | 9.64 | 15 | 311936 | 19947 | 53017168 |
Infusion site erythema | 70.46 | 9.64 | 158 | 311793 | 8664 | 53028451 |
Psoriatic arthropathy | 70.26 | 9.64 | 108 | 311843 | 48082 | 52989033 |
Throat irritation | 67.84 | 9.64 | 365 | 311586 | 31316 | 53005799 |
Infusion site extravasation | 65.53 | 9.64 | 125 | 311826 | 6107 | 53031008 |
Accidental overdose | 65.37 | 9.64 | 274 | 311677 | 21205 | 53015910 |
Nausea | 64.96 | 9.64 | 3690 | 308261 | 752401 | 52284714 |
Hospitalisation | 64.90 | 9.64 | 206 | 311745 | 70806 | 52966309 |
Suicide attempt | 64.00 | 9.64 | 569 | 311382 | 57599 | 52979516 |
Myocardial infarction | 63.85 | 9.64 | 331 | 311620 | 99023 | 52938092 |
Injection site swelling | 63.63 | 9.64 | 94 | 311857 | 42534 | 52994581 |
Suspected suicide | 63.41 | 9.64 | 101 | 311850 | 4267 | 53032848 |
Product quality issue | 63.08 | 9.64 | 74 | 311877 | 36949 | 53000166 |
Pyroglutamate increased | 62.24 | 9.64 | 37 | 311914 | 429 | 53036686 |
Drug ineffective | 62.21 | 9.64 | 4034 | 307917 | 813211 | 52223904 |
Blood pressure systolic increased | 61.46 | 9.64 | 384 | 311567 | 34793 | 53002322 |
Coma | 61.24 | 9.64 | 591 | 311360 | 61192 | 52975923 |
Product prescribing error | 59.64 | 9.64 | 30 | 311921 | 23001 | 53014114 |
Decreased appetite | 59.60 | 9.64 | 891 | 311060 | 214083 | 52823032 |
Mucosal inflammation | 59.43 | 9.64 | 99 | 311852 | 42685 | 52994430 |
Paraesthesia | 58.85 | 9.64 | 470 | 311481 | 127045 | 52910070 |
Respiratory disorder | 58.82 | 9.64 | 371 | 311580 | 33726 | 53003389 |
Confusional state | 57.51 | 9.64 | 1515 | 310436 | 192706 | 52844409 |
Contraindicated product administered | 57.09 | 9.64 | 1112 | 310839 | 134517 | 52902598 |
Product substitution issue | 56.24 | 9.64 | 12 | 311939 | 15854 | 53021261 |
Cardiac arrest | 55.55 | 9.64 | 812 | 311139 | 92855 | 52944260 |
Heart rate increased | 55.47 | 9.64 | 730 | 311221 | 81585 | 52955530 |
Blood calcium decreased | 55.25 | 9.64 | 246 | 311705 | 19548 | 53017567 |
Drug interaction | 55.11 | 9.64 | 926 | 311025 | 218403 | 52818712 |
Abortion spontaneous | 55.05 | 9.64 | 119 | 311832 | 46516 | 52990599 |
Drug hypersensitivity | 53.99 | 9.64 | 1161 | 310790 | 264081 | 52773034 |
Electric shock | 53.28 | 9.64 | 46 | 311905 | 991 | 53036124 |
Cerebrovascular accident | 53.10 | 9.64 | 378 | 311573 | 104796 | 52932319 |
Arthralgia | 53.08 | 9.64 | 3109 | 308842 | 436674 | 52600441 |
Glossodynia | 52.42 | 9.64 | 851 | 311100 | 99440 | 52937675 |
Cardiac failure | 52.38 | 9.64 | 291 | 311660 | 85553 | 52951562 |
Therapy cessation | 52.20 | 9.64 | 52 | 311899 | 27973 | 53009142 |
Neuropathy peripheral | 51.54 | 9.64 | 372 | 311579 | 102815 | 52934300 |
Injection site warmth | 51.50 | 9.64 | 10 | 311941 | 14118 | 53022997 |
Infusion site pruritus | 50.42 | 9.64 | 84 | 311867 | 3686 | 53033429 |
Therapeutic product effect incomplete | 50.27 | 9.64 | 322 | 311629 | 91462 | 52945653 |
Bone marrow failure | 49.39 | 9.64 | 62 | 311889 | 30053 | 53007062 |
Liver injury | 48.93 | 9.64 | 257 | 311694 | 21846 | 53015269 |
Crystal urine present | 48.70 | 9.64 | 51 | 311900 | 1409 | 53035706 |
International normalised ratio increased | 48.38 | 9.64 | 459 | 311492 | 47302 | 52989813 |
Methaemoglobinaemia | 48.35 | 9.64 | 63 | 311888 | 2209 | 53034906 |
Night sweats | 48.25 | 9.64 | 360 | 311591 | 34587 | 53002528 |
Pyrexia | 47.99 | 9.64 | 2847 | 309104 | 400346 | 52636769 |
Arthropathy | 47.99 | 9.64 | 1124 | 310827 | 140329 | 52896786 |
Pancytopenia | 47.77 | 9.64 | 323 | 311628 | 90605 | 52946510 |
Dizziness | 47.61 | 9.64 | 1739 | 310212 | 370520 | 52666595 |
Device malfunction | 47.14 | 9.64 | 17 | 311934 | 15891 | 53021224 |
Anion gap abnormal | 46.78 | 9.64 | 28 | 311923 | 329 | 53036786 |
Hyperkalaemia | 46.41 | 9.64 | 162 | 311789 | 54094 | 52983021 |
Muscle spasms | 44.84 | 9.64 | 538 | 311413 | 134257 | 52902858 |
Pain | 44.78 | 9.64 | 4007 | 307944 | 584391 | 52452724 |
Hyponatraemia | 44.44 | 9.64 | 413 | 311538 | 108194 | 52928921 |
Orthostatic hypotension | 44.24 | 9.64 | 312 | 311639 | 29441 | 53007674 |
Palmar-plantar erythrodysaesthesia syndrome | 43.91 | 9.64 | 37 | 311914 | 21569 | 53015546 |
Heart rate irregular | 43.74 | 9.64 | 235 | 311716 | 20149 | 53016966 |
White blood cells urine positive | 42.76 | 9.64 | 87 | 311864 | 4458 | 53032657 |
Cardiac failure congestive | 42.73 | 9.64 | 342 | 311609 | 92415 | 52944700 |
No adverse event | 42.47 | 9.64 | 105 | 311846 | 39160 | 52997955 |
Alanine aminotransferase increased | 41.82 | 9.64 | 785 | 311166 | 94310 | 52942805 |
Soft tissue disorder | 41.41 | 9.64 | 83 | 311868 | 4207 | 53032908 |
Cognitive disorder | 41.29 | 9.64 | 422 | 311529 | 44356 | 52992759 |
Infusion site bruising | 40.87 | 9.64 | 56 | 311895 | 2063 | 53035052 |
Device dislocation | 40.38 | 9.64 | 47 | 311904 | 23550 | 53013565 |
Death | 40.14 | 9.64 | 2510 | 309441 | 354722 | 52682393 |
Body temperature decreased | 40.07 | 9.64 | 198 | 311753 | 16429 | 53020686 |
Drug intolerance | 40.00 | 9.64 | 1524 | 310427 | 203969 | 52833146 |
Red blood cell sedimentation rate abnormal | 39.78 | 9.64 | 21 | 311930 | 15668 | 53021447 |
Diabetes mellitus | 39.64 | 9.64 | 171 | 311780 | 53728 | 52983387 |
Rash | 39.52 | 9.64 | 3074 | 308877 | 443117 | 52593998 |
Injection site mass | 39.24 | 9.64 | 23 | 311928 | 16191 | 53020924 |
Neoplasm progression | 39.04 | 9.64 | 72 | 311879 | 29847 | 53007268 |
Administration site swelling | 38.57 | 9.64 | 41 | 311910 | 1153 | 53035962 |
Pemphigus | 38.52 | 9.64 | 837 | 311114 | 103194 | 52933921 |
Injection site urticaria | 38.17 | 9.64 | 13 | 311938 | 12594 | 53024521 |
Sedation | 37.79 | 9.64 | 300 | 311651 | 29375 | 53007740 |
Product storage error | 37.29 | 9.64 | 15 | 311936 | 13115 | 53024000 |
Interstitial lung disease | 36.15 | 9.64 | 198 | 311753 | 58424 | 52978691 |
Urine abnormality | 36.11 | 9.64 | 101 | 311850 | 6359 | 53030756 |
Hypotension | 36.08 | 9.64 | 1824 | 310127 | 252252 | 52784863 |
Feeling abnormal | 36.02 | 9.64 | 565 | 311386 | 134736 | 52902379 |
Urinary sediment present | 34.76 | 9.64 | 51 | 311900 | 2003 | 53035112 |
Rheumatic fever | 34.69 | 9.64 | 156 | 311795 | 12448 | 53024667 |
Blood pressure diastolic increased | 34.67 | 9.64 | 106 | 311845 | 7018 | 53030097 |
Infusion site nodule | 34.54 | 9.64 | 38 | 311913 | 1112 | 53036003 |
Epilepsy | 34.53 | 9.64 | 61 | 311890 | 25706 | 53011409 |
Injection site haemorrhage | 34.52 | 9.64 | 47 | 311904 | 22004 | 53015111 |
Hypertensive crisis | 34.51 | 9.64 | 21 | 311930 | 14485 | 53022630 |
Substance abuse | 34.24 | 9.64 | 79 | 311872 | 4415 | 53032700 |
Unresponsive to stimuli | 34.23 | 9.64 | 322 | 311629 | 33104 | 53004011 |
Fracture | 34.06 | 9.64 | 33 | 311918 | 17986 | 53019129 |
Malignant neoplasm progression | 33.77 | 9.64 | 262 | 311689 | 71279 | 52965836 |
Oedema peripheral | 33.72 | 9.64 | 751 | 311200 | 170036 | 52867079 |
Malaise | 33.36 | 9.64 | 1730 | 310221 | 355887 | 52681228 |
Administration site pain | 33.23 | 9.64 | 30 | 311921 | 687 | 53036428 |
Respiratory rate increased | 33.14 | 9.64 | 152 | 311799 | 12231 | 53024884 |
Toxicologic test abnormal | 33.12 | 9.64 | 29 | 311922 | 637 | 53036478 |
Acute kidney injury | 33.07 | 9.64 | 1183 | 310768 | 252685 | 52784430 |
Device issue | 33.07 | 9.64 | 47 | 311904 | 21611 | 53015504 |
Injection site rash | 32.95 | 9.64 | 29 | 311922 | 16550 | 53020565 |
Foetal exposure during pregnancy | 32.92 | 9.64 | 99 | 311852 | 34616 | 53002499 |
Transient ischaemic attack | 32.38 | 9.64 | 104 | 311847 | 35621 | 53001494 |
Vision blurred | 32.29 | 9.64 | 332 | 311619 | 85272 | 52951843 |
Bone pain | 32.00 | 9.64 | 170 | 311781 | 50552 | 52986563 |
Epistaxis | 31.80 | 9.64 | 253 | 311698 | 68457 | 52968658 |
Product use in unapproved indication | 31.56 | 9.64 | 464 | 311487 | 111825 | 52925290 |
Swollen joint count increased | 31.27 | 9.64 | 140 | 311811 | 11150 | 53025965 |
Surgery | 31.15 | 9.64 | 90 | 311861 | 31874 | 53005241 |
Myelodysplastic syndrome | 30.93 | 9.64 | 31 | 311920 | 16629 | 53020486 |
Device difficult to use | 30.81 | 9.64 | 11 | 311940 | 10348 | 53026767 |
Contusion | 30.25 | 9.64 | 855 | 311096 | 109877 | 52927238 |
Posterior reversible encephalopathy syndrome | 30.08 | 9.64 | 30 | 311921 | 16130 | 53020985 |
Red blood cells urine positive | 29.95 | 9.64 | 58 | 311893 | 2866 | 53034249 |
Off label use | 29.83 | 9.64 | 2367 | 309584 | 469845 | 52567270 |
Poor venous access | 29.38 | 9.64 | 126 | 311825 | 9849 | 53027266 |
Brain death | 28.80 | 9.64 | 58 | 311893 | 2950 | 53034165 |
Osteonecrosis | 28.79 | 9.64 | 71 | 311880 | 26504 | 53010611 |
Fall | 28.67 | 9.64 | 1760 | 310191 | 356680 | 52680435 |
Jaundice cholestatic | 28.49 | 9.64 | 84 | 311867 | 5450 | 53031665 |
Pyroglutamic acidosis | 28.49 | 9.64 | 21 | 311930 | 357 | 53036758 |
Renal impairment | 28.29 | 9.64 | 331 | 311620 | 82987 | 52954128 |
Prothrombin time prolonged | 28.11 | 9.64 | 123 | 311828 | 9699 | 53027416 |
Depression | 27.86 | 9.64 | 836 | 311115 | 182216 | 52854899 |
Intervertebral discitis | 27.79 | 9.64 | 55 | 311896 | 2762 | 53034353 |
Body temperature fluctuation | 27.67 | 9.64 | 46 | 311905 | 2015 | 53035100 |
Lymphocyte count decreased | 27.62 | 9.64 | 268 | 311683 | 27784 | 53009331 |
Rash pruritic | 27.60 | 9.64 | 175 | 311776 | 49835 | 52987280 |
Dyspnoea exertional | 27.59 | 9.64 | 198 | 311753 | 54802 | 52982313 |
Accidental exposure to product | 27.45 | 9.64 | 61 | 311890 | 23613 | 53013502 |
Suicidal ideation | 27.00 | 9.64 | 225 | 311726 | 60286 | 52976829 |
Dry skin | 26.89 | 9.64 | 157 | 311794 | 45603 | 52991512 |
Brain oedema | 26.88 | 9.64 | 153 | 311798 | 13405 | 53023710 |
Blood parathyroid hormone decreased | 26.41 | 9.64 | 3 | 311948 | 6315 | 53030800 |
Red cell distribution width increased | 26.25 | 9.64 | 113 | 311838 | 8847 | 53028268 |
Myelosuppression | 26.03 | 9.64 | 22 | 311929 | 12806 | 53024309 |
Hypokalaemia | 26.03 | 9.64 | 402 | 311549 | 96115 | 52941000 |
Memory impairment | 25.67 | 9.64 | 345 | 311606 | 84412 | 52952703 |
Labelled drug-drug interaction medication error | 25.62 | 9.64 | 16 | 311935 | 10883 | 53026232 |
Analgesic drug level above therapeutic | 25.52 | 9.64 | 15 | 311936 | 170 | 53036945 |
Seizure | 25.40 | 9.64 | 570 | 311381 | 128939 | 52908176 |
Femur fracture | 25.35 | 9.64 | 132 | 311819 | 39453 | 52997662 |
Urticaria | 25.29 | 9.64 | 1003 | 310948 | 134882 | 52902233 |
Upper respiratory tract infection | 25.27 | 9.64 | 555 | 311396 | 68542 | 52968573 |
Plasma cell myeloma | 25.17 | 9.64 | 170 | 311781 | 47704 | 52989411 |
Breast cancer | 25.09 | 9.64 | 177 | 311774 | 49181 | 52987934 |
Urine leukocyte esterase positive | 25.05 | 9.64 | 54 | 311897 | 2882 | 53034233 |
Aspartate aminotransferase increased | 24.98 | 9.64 | 656 | 311295 | 83373 | 52953742 |
Lymphocyte percentage decreased | 24.82 | 9.64 | 53 | 311898 | 2810 | 53034305 |
Ejection fraction decreased | 24.81 | 9.64 | 49 | 311902 | 19799 | 53017316 |
Neutrophil percentage increased | 24.78 | 9.64 | 53 | 311898 | 2813 | 53034302 |
Hyperlipidaemia | 24.55 | 9.64 | 48 | 311903 | 19467 | 53017648 |
Accidental death | 24.53 | 9.64 | 40 | 311911 | 1724 | 53035391 |
Injection site induration | 24.41 | 9.64 | 10 | 311941 | 8648 | 53028467 |
Hypomania | 24.09 | 9.64 | 73 | 311878 | 4809 | 53032306 |
Ear pruritus | 24.08 | 9.64 | 48 | 311903 | 2423 | 53034692 |
Administration site erythema | 23.85 | 9.64 | 23 | 311928 | 574 | 53036541 |
Blood count abnormal | 23.84 | 9.64 | 52 | 311899 | 20263 | 53016852 |
Thrombocytopenia | 23.80 | 9.64 | 623 | 311328 | 138104 | 52899011 |
Liver transplant | 23.77 | 9.64 | 48 | 311903 | 2446 | 53034669 |
Hypothermia | 23.73 | 9.64 | 144 | 311807 | 12912 | 53024203 |
Acidosis | 23.54 | 9.64 | 130 | 311821 | 11262 | 53025853 |
White blood cell count decreased | 23.52 | 9.64 | 551 | 311400 | 123924 | 52913191 |
Gastrooesophageal reflux disease | 23.43 | 9.64 | 341 | 311610 | 82322 | 52954793 |
Lactic acidosis | 23.42 | 9.64 | 125 | 311826 | 37128 | 52999987 |
Syncope | 23.38 | 9.64 | 488 | 311463 | 111505 | 52925610 |
Diabetic ketoacidosis | 23.35 | 9.64 | 51 | 311900 | 19864 | 53017251 |
Polyneuropathy | 23.03 | 9.64 | 26 | 311925 | 13207 | 53023908 |
Disturbance in attention | 22.96 | 9.64 | 113 | 311838 | 34270 | 53002845 |
Specific gravity urine decreased | 22.87 | 9.64 | 23 | 311928 | 605 | 53036510 |
Gait disturbance | 22.80 | 9.64 | 731 | 311220 | 158111 | 52879004 |
Therapy interrupted | 22.60 | 9.64 | 50 | 311901 | 19386 | 53017729 |
Forced expiratory volume decreased | 22.50 | 9.64 | 3 | 311948 | 5582 | 53031533 |
Hypocalcaemia | 22.23 | 9.64 | 92 | 311859 | 29245 | 53007870 |
Second primary malignancy | 22.21 | 9.64 | 7 | 311944 | 7125 | 53029990 |
Underdose | 22.16 | 9.64 | 59 | 311892 | 21463 | 53015652 |
Asthma | 22.12 | 9.64 | 477 | 311474 | 108495 | 52928620 |
Hypercalcaemia | 21.98 | 9.64 | 71 | 311880 | 24277 | 53012838 |
Leukopenia | 21.90 | 9.64 | 300 | 311651 | 73163 | 52963952 |
Multiple sclerosis relapse | 21.76 | 9.64 | 163 | 311788 | 44690 | 52992425 |
Coronary artery disease | 21.69 | 9.64 | 111 | 311840 | 33326 | 53003789 |
Palpitations | 21.65 | 9.64 | 445 | 311506 | 101903 | 52935212 |
Gestational diabetes | 21.53 | 9.64 | 10 | 311941 | 8029 | 53029086 |
Dehydration | 21.40 | 9.64 | 787 | 311164 | 167623 | 52869492 |
Postmortem blood drug level increased | 21.24 | 9.64 | 21 | 311930 | 541 | 53036574 |
Drug screen positive | 21.12 | 9.64 | 60 | 311891 | 3812 | 53033303 |
Complication associated with device | 21.00 | 9.64 | 39 | 311912 | 16126 | 53020989 |
Ductus arteriosus premature closure | 20.91 | 9.64 | 17 | 311934 | 336 | 53036779 |
Bradypnoea | 20.90 | 9.64 | 54 | 311897 | 3243 | 53033872 |
Blood pH decreased | 20.89 | 9.64 | 47 | 311904 | 2583 | 53034532 |
Breast cancer metastatic | 20.80 | 9.64 | 36 | 311915 | 15292 | 53021823 |
Blood creatine increased | 20.71 | 9.64 | 70 | 311881 | 4887 | 53032228 |
Pulmonary arterial hypertension | 20.59 | 9.64 | 85 | 311866 | 27037 | 53010078 |
Withdrawal syndrome | 20.57 | 9.64 | 52 | 311899 | 19249 | 53017866 |
Vertigo | 20.53 | 9.64 | 219 | 311732 | 55862 | 52981253 |
Drug ineffective for unapproved indication | 20.44 | 9.64 | 58 | 311893 | 20662 | 53016453 |
Tremor | 20.44 | 9.64 | 569 | 311382 | 125167 | 52911948 |
Hypoaesthesia | 20.07 | 9.64 | 608 | 311343 | 132387 | 52904728 |
Infusion site urticaria | 20.03 | 9.64 | 25 | 311926 | 839 | 53036276 |
Visual acuity reduced | 20.00 | 9.64 | 66 | 311885 | 22419 | 53014696 |
Pneumocystis jirovecii pneumonia | 19.99 | 9.64 | 41 | 311910 | 16337 | 53020778 |
Transplant rejection | 19.88 | 9.64 | 18 | 311933 | 10133 | 53026982 |
Device use error | 19.82 | 9.64 | 4 | 311947 | 5495 | 53031620 |
Product adhesion issue | 19.81 | 9.64 | 4 | 311947 | 5493 | 53031622 |
Cytomegalovirus infection | 19.79 | 9.64 | 54 | 311897 | 19485 | 53017630 |
Disease recurrence | 19.67 | 9.64 | 60 | 311891 | 20886 | 53016229 |
Anaphylactic shock | 19.65 | 9.64 | 64 | 311887 | 21829 | 53015286 |
Ageusia | 19.63 | 9.64 | 27 | 311924 | 12587 | 53024528 |
Pathogen resistance | 19.45 | 9.64 | 7 | 311944 | 6553 | 53030562 |
Dysgeusia | 19.43 | 9.64 | 159 | 311792 | 42772 | 52994343 |
Haematotoxicity | 19.40 | 9.64 | 11 | 311940 | 7886 | 53029229 |
Abdominal distension | 19.31 | 9.64 | 339 | 311612 | 79451 | 52957664 |
Infusion site irritation | 19.21 | 9.64 | 21 | 311930 | 610 | 53036505 |
Anion gap increased | 18.74 | 9.64 | 33 | 311918 | 1515 | 53035600 |
Asphyxia | 18.52 | 9.64 | 76 | 311875 | 5825 | 53031290 |
Genital haemorrhage | 18.50 | 9.64 | 9 | 311942 | 7035 | 53030080 |
Iron deficiency anaemia | 18.33 | 9.64 | 52 | 311899 | 18528 | 53018587 |
Band neutrophil count increased | 18.33 | 9.64 | 16 | 311935 | 350 | 53036765 |
Haemolysis | 18.33 | 9.64 | 81 | 311870 | 6415 | 53030700 |
Haemorrhage | 18.30 | 9.64 | 234 | 311717 | 57753 | 52979362 |
Sepsis | 18.22 | 9.64 | 686 | 311265 | 145743 | 52891372 |
Atrial fibrillation | 18.21 | 9.64 | 505 | 311446 | 111147 | 52925968 |
Drug withdrawal syndrome | 18.19 | 9.64 | 93 | 311858 | 27929 | 53009186 |
Basal cell carcinoma | 18.16 | 9.64 | 73 | 311878 | 23396 | 53013719 |
Bacterial test | 18.12 | 9.64 | 29 | 311922 | 1230 | 53035885 |
Hepatic cirrhosis | 18.11 | 9.64 | 50 | 311901 | 17972 | 53019143 |
Pneumonia streptococcal | 18.09 | 9.64 | 35 | 311916 | 1728 | 53035387 |
Osmolar gap | 18.00 | 9.64 | 10 | 311941 | 101 | 53037014 |
Systemic lupus erythematosus | 17.90 | 9.64 | 901 | 311050 | 124513 | 52912602 |
Inappropriate antidiuretic hormone secretion | 17.77 | 9.64 | 38 | 311913 | 14913 | 53022202 |
Febrile bone marrow aplasia | 17.68 | 9.64 | 10 | 311941 | 7179 | 53029936 |
Infusion site haemorrhage | 17.61 | 9.64 | 46 | 311905 | 2781 | 53034334 |
Renal failure neonatal | 17.38 | 9.64 | 12 | 311939 | 183 | 53036932 |
Aphasia | 17.34 | 9.64 | 107 | 311844 | 30671 | 53006444 |
Post procedural pulmonary embolism | 17.33 | 9.64 | 14 | 311937 | 274 | 53036841 |
Eosinophil percentage increased | 17.32 | 9.64 | 25 | 311926 | 967 | 53036148 |
Blood creatinine decreased | 17.30 | 9.64 | 68 | 311883 | 5110 | 53032005 |
Blood urine present | 17.30 | 9.64 | 135 | 311816 | 13150 | 53023965 |
Peritonitis bacterial | 17.29 | 9.64 | 18 | 311933 | 9487 | 53027628 |
Lupus-like syndrome | 17.26 | 9.64 | 17 | 311934 | 9195 | 53027920 |
Tinnitus | 17.25 | 9.64 | 106 | 311845 | 30413 | 53006702 |
Musculoskeletal disorder | 17.25 | 9.64 | 49 | 311902 | 17450 | 53019665 |
Bone erosion | 17.22 | 9.64 | 24 | 311927 | 11128 | 53025987 |
Smear cervix abnormal | 17.02 | 9.64 | 45 | 311906 | 2741 | 53034374 |
Metastases to bone | 17.01 | 9.64 | 57 | 311894 | 19271 | 53017844 |
Hepatic encephalopathy | 16.81 | 9.64 | 115 | 311836 | 10744 | 53026371 |
Opiates positive | 16.74 | 9.64 | 15 | 311936 | 340 | 53036775 |
Pneumonia viral | 16.65 | 9.64 | 84 | 311867 | 7028 | 53030087 |
Oral discomfort | 16.55 | 9.64 | 16 | 311935 | 8730 | 53028385 |
Cerebral haemorrhage | 16.53 | 9.64 | 105 | 311846 | 29891 | 53007224 |
Myalgia | 16.47 | 9.64 | 626 | 311325 | 132865 | 52904250 |
Ventricular extrasystoles | 16.40 | 9.64 | 27 | 311924 | 11697 | 53025418 |
Intermenstrual bleeding | 16.36 | 9.64 | 16 | 311935 | 8682 | 53028433 |
Haemoglobin urine present | 16.33 | 9.64 | 22 | 311929 | 797 | 53036318 |
Osteoarthritis | 16.26 | 9.64 | 302 | 311649 | 70184 | 52966931 |
Spinal stenosis | 16.26 | 9.64 | 37 | 311914 | 14204 | 53022911 |
Acute myeloid leukaemia | 16.26 | 9.64 | 48 | 311903 | 16884 | 53020231 |
Mean cell haemoglobin concentration increased | 16.25 | 9.64 | 17 | 311934 | 469 | 53036646 |
Extrapyramidal disorder | 16.04 | 9.64 | 30 | 311921 | 12372 | 53024743 |
Chest pain | 15.85 | 9.64 | 930 | 311021 | 189255 | 52847860 |
Mood swings | 15.78 | 9.64 | 51 | 311900 | 17435 | 53019680 |
Swollen tongue | 15.53 | 9.64 | 112 | 311839 | 30968 | 53006147 |
Necrosis ischaemic | 15.52 | 9.64 | 22 | 311929 | 837 | 53036278 |
Burning sensation | 15.43 | 9.64 | 193 | 311758 | 47820 | 52989295 |
Dysphoria | 15.37 | 9.64 | 6 | 311945 | 5343 | 53031772 |
Skin ulcer | 15.35 | 9.64 | 136 | 311815 | 35983 | 53001132 |
Metastases to liver | 15.32 | 9.64 | 69 | 311882 | 21427 | 53015688 |
Serotonin syndrome | 15.28 | 9.64 | 228 | 311723 | 26178 | 53010937 |
Ischaemic stroke | 15.20 | 9.64 | 54 | 311897 | 17939 | 53019176 |
Neurotoxicity | 15.11 | 9.64 | 43 | 311908 | 15306 | 53021809 |
Transplant dysfunction | 15.11 | 9.64 | 5 | 311946 | 4933 | 53032182 |
Multiple drug therapy | 15.10 | 9.64 | 29 | 311922 | 1424 | 53035691 |
Electrolyte imbalance | 15.08 | 9.64 | 58 | 311893 | 18826 | 53018289 |
Hepatocellular injury | 15.01 | 9.64 | 108 | 311843 | 29878 | 53007237 |
Urine analysis abnormal | 14.96 | 9.64 | 59 | 311892 | 4441 | 53032674 |
Mobility decreased | 14.89 | 9.64 | 566 | 311385 | 75705 | 52961410 |
Hyperglycaemia | 14.89 | 9.64 | 156 | 311795 | 39928 | 52997187 |
Pain in extremity | 14.83 | 9.64 | 1450 | 310501 | 283600 | 52753515 |
Metastases to lymph nodes | 14.80 | 9.64 | 13 | 311938 | 7427 | 53029688 |
Haemophagocytic lymphohistiocytosis | 14.79 | 9.64 | 19 | 311932 | 9118 | 53027997 |
Angioedema | 14.73 | 9.64 | 166 | 311785 | 41910 | 52995205 |
Temperature regulation disorder | 14.67 | 9.64 | 56 | 311895 | 4151 | 53032964 |
Therapeutic response decreased | 14.63 | 9.64 | 193 | 311758 | 47376 | 52989739 |
Transfusion-related acute lung injury | 14.60 | 9.64 | 9 | 311942 | 112 | 53037003 |
Taste disorder | 14.59 | 9.64 | 15 | 311936 | 7953 | 53029162 |
Infusion site mass | 14.54 | 9.64 | 24 | 311927 | 1045 | 53036070 |
Cardiovascular disorder | 14.38 | 9.64 | 32 | 311919 | 12381 | 53024734 |
Therapeutic response shortened | 14.33 | 9.64 | 80 | 311871 | 6959 | 53030156 |
Irritability | 14.30 | 9.64 | 114 | 311837 | 30839 | 53006276 |
Vaginal haemorrhage | 14.26 | 9.64 | 95 | 311856 | 26746 | 53010369 |
Joint stiffness | 14.24 | 9.64 | 111 | 311840 | 30172 | 53006943 |
Galactorrhoea | 14.20 | 9.64 | 3 | 311948 | 3992 | 53033123 |
Device breakage | 14.17 | 9.64 | 25 | 311926 | 10542 | 53026573 |
Heavy menstrual bleeding | 14.12 | 9.64 | 53 | 311898 | 17323 | 53019792 |
Ductus arteriosus stenosis foetal | 14.08 | 9.64 | 10 | 311941 | 160 | 53036955 |
Premature delivery | 14.07 | 9.64 | 92 | 311859 | 26012 | 53011103 |
Renal failure | 14.06 | 9.64 | 558 | 311393 | 117894 | 52919221 |
Low turnover osteopathy | 13.99 | 9.64 | 4 | 311947 | 4336 | 53032779 |
Cardiomyopathy | 13.96 | 9.64 | 52 | 311899 | 17036 | 53020079 |
Administration site pruritus | 13.90 | 9.64 | 13 | 311938 | 312 | 53036803 |
Left ventricular dysfunction | 13.83 | 9.64 | 28 | 311923 | 11209 | 53025906 |
Infusion site discomfort | 13.76 | 9.64 | 20 | 311931 | 779 | 53036336 |
Akathisia | 13.69 | 9.64 | 18 | 311933 | 8553 | 53028562 |
Beta haemolytic streptococcal infection | 13.68 | 9.64 | 34 | 311917 | 1993 | 53035122 |
Administration site extravasation | 13.68 | 9.64 | 19 | 311932 | 709 | 53036406 |
Culture urine positive | 13.65 | 9.64 | 49 | 311902 | 3526 | 53033589 |
Coma hepatic | 13.60 | 9.64 | 18 | 311933 | 641 | 53036474 |
Antidepressant drug level above therapeutic | 13.60 | 9.64 | 14 | 311937 | 379 | 53036736 |
Thrombotic microangiopathy | 13.53 | 9.64 | 21 | 311930 | 9316 | 53027799 |
Incorrect drug administration rate | 13.53 | 9.64 | 38 | 311913 | 2398 | 53034717 |
Alpha 1 microglobulin increased | 13.48 | 9.64 | 7 | 311944 | 61 | 53037054 |
Gastrointestinal haemorrhage | 13.44 | 9.64 | 362 | 311589 | 79968 | 52957147 |
Drug-induced liver injury | 13.43 | 9.64 | 243 | 311708 | 28990 | 53008125 |
Fear of injection | 13.42 | 9.64 | 8 | 311943 | 5581 | 53031534 |
Unevaluable event | 13.39 | 9.64 | 206 | 311745 | 49292 | 52987823 |
Vitamin K deficiency | 13.36 | 9.64 | 15 | 311936 | 449 | 53036666 |
Sputum culture positive | 13.31 | 9.64 | 28 | 311923 | 1469 | 53035646 |
Skin necrosis | 13.30 | 9.64 | 26 | 311925 | 10546 | 53026569 |
Full blood count decreased | 13.30 | 9.64 | 84 | 311867 | 23945 | 53013170 |
Flatulence | 13.25 | 9.64 | 119 | 311832 | 31398 | 53005717 |
Low density lipoprotein increased | 13.23 | 9.64 | 10 | 311941 | 6156 | 53030959 |
Ear infection | 13.23 | 9.64 | 219 | 311732 | 25681 | 53011434 |
Metastases to central nervous system | 13.23 | 9.64 | 32 | 311919 | 12025 | 53025090 |
Application site pain | 13.22 | 9.64 | 4 | 311947 | 4179 | 53032936 |
Therapeutic response unexpected | 13.19 | 9.64 | 54 | 311897 | 17216 | 53019899 |
Transaminases increased | 12.98 | 9.64 | 248 | 311703 | 29884 | 53007231 |
Adverse drug reaction | 12.92 | 9.64 | 228 | 311723 | 53397 | 52983718 |
Injection site extravasation | 12.91 | 9.64 | 82 | 311869 | 7470 | 53029645 |
Precancerous cells present | 12.90 | 9.64 | 25 | 311926 | 1236 | 53035879 |
Blood glucose increased | 12.84 | 9.64 | 349 | 311602 | 77012 | 52960103 |
Cells in urine | 12.81 | 9.64 | 10 | 311941 | 186 | 53036929 |
Skin exfoliation | 12.77 | 9.64 | 142 | 311809 | 35941 | 53001174 |
Unintended pregnancy | 12.76 | 9.64 | 10 | 311941 | 6043 | 53031072 |
Cerebral infarction | 12.75 | 9.64 | 87 | 311864 | 24357 | 53012758 |
Priapism | 12.66 | 9.64 | 7 | 311944 | 70 | 53037045 |
Blood uric acid decreased | 12.63 | 9.64 | 18 | 311933 | 688 | 53036427 |
Encephalopathy | 12.62 | 9.64 | 293 | 311658 | 36515 | 53000600 |
Cardiac disorder | 12.53 | 9.64 | 196 | 311755 | 46770 | 52990345 |
Pain in jaw | 12.51 | 9.64 | 165 | 311786 | 40504 | 52996611 |
Maternal exposure before pregnancy | 12.49 | 9.64 | 9 | 311942 | 5677 | 53031438 |
Pregnancy with contraceptive device | 12.45 | 9.64 | 6 | 311945 | 4715 | 53032400 |
Congestive hepatopathy | 12.44 | 9.64 | 39 | 311912 | 2617 | 53034498 |
Renal papillary necrosis | 12.44 | 9.64 | 11 | 311940 | 245 | 53036870 |
Post-traumatic stress disorder | 12.43 | 9.64 | 58 | 311893 | 4700 | 53032415 |
Post transplant lymphoproliferative disorder | 12.40 | 9.64 | 5 | 311946 | 4366 | 53032749 |
Vital capacity decreased | 12.39 | 9.64 | 22 | 311929 | 1017 | 53036098 |
Urinary casts | 12.29 | 9.64 | 17 | 311934 | 632 | 53036483 |
Thinking abnormal | 12.24 | 9.64 | 27 | 311924 | 10481 | 53026634 |
Lip swelling | 12.19 | 9.64 | 101 | 311850 | 27100 | 53010015 |
Bursitis | 12.17 | 9.64 | 192 | 311759 | 22300 | 53014815 |
Acute graft versus host disease | 12.15 | 9.64 | 5 | 311946 | 4312 | 53032803 |
Parosmia | 12.12 | 9.64 | 6 | 311945 | 4644 | 53032471 |
Adverse event | 12.12 | 9.64 | 168 | 311783 | 40893 | 52996222 |
Metastases to lung | 12.11 | 9.64 | 32 | 311919 | 11672 | 53025443 |
Caesarean section | 12.10 | 9.64 | 56 | 311895 | 17264 | 53019851 |
Loss of consciousness | 12.09 | 9.64 | 545 | 311406 | 113667 | 52923448 |
Platelet count decreased | 12.02 | 9.64 | 513 | 311438 | 107586 | 52929529 |
Base excess | 12.01 | 9.64 | 7 | 311944 | 78 | 53037037 |
Oedema | 11.93 | 9.64 | 337 | 311614 | 74009 | 52963106 |
Bronchitis | 11.93 | 9.64 | 783 | 311168 | 111116 | 52925999 |
Pulmonary hypertension | 11.91 | 9.64 | 150 | 311801 | 37120 | 52999995 |
Status epilepticus | 11.89 | 9.64 | 47 | 311904 | 15137 | 53021978 |
Panniculitis | 11.89 | 9.64 | 17 | 311934 | 7797 | 53029318 |
Myelocyte count increased | 11.83 | 9.64 | 13 | 311938 | 380 | 53036735 |
Blood bilirubin increased | 11.82 | 9.64 | 283 | 311668 | 35447 | 53001668 |
Dyskinesia | 11.78 | 9.64 | 124 | 311827 | 31709 | 53005406 |
Urine oxalate increased | 11.75 | 9.64 | 10 | 311941 | 211 | 53036904 |
Injection site discolouration | 11.74 | 9.64 | 15 | 311936 | 7215 | 53029900 |
Rhinitis allergic | 11.73 | 9.64 | 17 | 311934 | 7756 | 53029359 |
Device related thrombosis | 11.69 | 9.64 | 25 | 311926 | 1327 | 53035788 |
Weight decreased | 11.68 | 9.64 | 1199 | 310752 | 233749 | 52803366 |
Hypomagnesaemia | 11.64 | 9.64 | 91 | 311860 | 24720 | 53012395 |
Neuroleptic malignant syndrome | 11.64 | 9.64 | 34 | 311917 | 11999 | 53025116 |
C-reactive protein abnormal | 11.62 | 9.64 | 96 | 311855 | 25774 | 53011341 |
Anxiety | 11.61 | 9.64 | 991 | 310960 | 195713 | 52841402 |
Nail bed inflammation | 11.58 | 9.64 | 13 | 311938 | 389 | 53036726 |
Band neutrophil percentage increased | 11.56 | 9.64 | 10 | 311941 | 216 | 53036899 |
Macular oedema | 11.44 | 9.64 | 5 | 311946 | 4160 | 53032955 |
Peripheral sensory neuropathy | 11.43 | 9.64 | 15 | 311936 | 7133 | 53029982 |
Pupillary light reflex tests abnormal | 11.41 | 9.64 | 9 | 311942 | 170 | 53036945 |
Product residue present | 11.40 | 9.64 | 5 | 311946 | 4151 | 53032964 |
Arrhythmia | 11.39 | 9.64 | 149 | 311802 | 36630 | 53000485 |
Acute myocardial infarction | 11.29 | 9.64 | 132 | 311819 | 33103 | 53004012 |
Ascites | 11.22 | 9.64 | 164 | 311787 | 39571 | 52997544 |
Blindness | 11.22 | 9.64 | 64 | 311887 | 18699 | 53018416 |
Accidental exposure to product by child | 11.22 | 9.64 | 23 | 311928 | 1185 | 53035930 |
Gait inability | 11.22 | 9.64 | 157 | 311794 | 38154 | 52998961 |
Corneal epithelium defect | 11.22 | 9.64 | 12 | 311939 | 340 | 53036775 |
Partial seizures | 11.20 | 9.64 | 9 | 311942 | 5371 | 53031744 |
Infective pulmonary exacerbation of cystic fibrosis | 11.17 | 9.64 | 31 | 311920 | 11125 | 53025990 |
Schizoaffective disorder | 11.17 | 9.64 | 33 | 311918 | 2144 | 53034971 |
Pharyngeal paraesthesia | 11.16 | 9.64 | 25 | 311926 | 1370 | 53035745 |
Administration site reaction | 11.15 | 9.64 | 10 | 311941 | 227 | 53036888 |
Ketoacidosis | 11.11 | 9.64 | 6 | 311945 | 4420 | 53032695 |
Traumatic liver injury | 11.11 | 9.64 | 11 | 311940 | 284 | 53036831 |
Vein collapse | 11.01 | 9.64 | 16 | 311935 | 623 | 53036492 |
Mitral valve incompetence | 11.00 | 9.64 | 68 | 311883 | 19483 | 53017632 |
Erysipelas | 10.99 | 9.64 | 16 | 311935 | 7285 | 53029830 |
Atypical femur fracture | 10.87 | 9.64 | 9 | 311942 | 5292 | 53031823 |
Hallucination, auditory | 10.86 | 9.64 | 34 | 311917 | 11739 | 53025376 |
Administration site bruise | 10.86 | 9.64 | 11 | 311940 | 292 | 53036823 |
Invasive ductal breast carcinoma | 10.80 | 9.64 | 14 | 311937 | 6693 | 53030422 |
Diplopia | 10.78 | 9.64 | 74 | 311877 | 20691 | 53016424 |
Congestive cardiomyopathy | 10.75 | 9.64 | 12 | 311939 | 6126 | 53030989 |
Sensitivity to weather change | 10.68 | 9.64 | 12 | 311939 | 6110 | 53031005 |
Obstructive airways disorder | 10.67 | 9.64 | 59 | 311892 | 17370 | 53019745 |
Angina unstable | 10.63 | 9.64 | 17 | 311934 | 7451 | 53029664 |
Procedural pain | 10.63 | 9.64 | 47 | 311904 | 14670 | 53022445 |
Gout | 10.61 | 9.64 | 37 | 311914 | 12362 | 53024753 |
Ventricular arrhythmia | 10.60 | 9.64 | 46 | 311905 | 3614 | 53033501 |
PCO2 decreased | 10.58 | 9.64 | 24 | 311927 | 1326 | 53035789 |
Haemarthrosis | 10.57 | 9.64 | 3 | 311948 | 3267 | 53033848 |
Therapy non-responder | 10.55 | 9.64 | 213 | 311738 | 48907 | 52988208 |
Magnesium deficiency | 10.53 | 9.64 | 14 | 311937 | 501 | 53036614 |
Device leakage | 10.52 | 9.64 | 12 | 311939 | 6068 | 53031047 |
Chemical poisoning | 10.52 | 9.64 | 6 | 311945 | 64 | 53037051 |
Diffuse large B-cell lymphoma | 10.49 | 9.64 | 14 | 311937 | 6611 | 53030504 |
Respiratory syncytial virus infection | 10.48 | 9.64 | 60 | 311891 | 5268 | 53031847 |
Muscular weakness | 10.47 | 9.64 | 483 | 311468 | 100509 | 52936606 |
Aplasia pure red cell | 10.46 | 9.64 | 7 | 311944 | 4589 | 53032526 |
Epstein-Barr virus infection | 10.45 | 9.64 | 17 | 311934 | 7401 | 53029714 |
Hemiparesis | 10.43 | 9.64 | 78 | 311873 | 21397 | 53015718 |
Embedded device | 10.42 | 9.64 | 3 | 311948 | 3238 | 53033877 |
Obesity | 10.42 | 9.64 | 56 | 311895 | 16606 | 53020509 |
Thrombosis | 10.42 | 9.64 | 273 | 311678 | 60520 | 52976595 |
Multiple-drug resistance | 10.39 | 9.64 | 3 | 311948 | 3232 | 53033883 |
Balint's syndrome | 10.38 | 9.64 | 3 | 311948 | 3 | 53037112 |
Urine bilirubin decreased | 10.38 | 9.64 | 3 | 311948 | 3 | 53037112 |
Eating disorder | 10.37 | 9.64 | 54 | 311897 | 16143 | 53020972 |
Cystic fibrosis | 10.36 | 9.64 | 5 | 311946 | 3926 | 53033189 |
Osmolar gap abnormal | 10.31 | 9.64 | 5 | 311946 | 37 | 53037078 |
Injury associated with device | 10.29 | 9.64 | 3 | 311948 | 3212 | 53033903 |
Complication of device insertion | 10.28 | 9.64 | 12 | 311939 | 6005 | 53031110 |
Dyspnoea | 10.22 | 9.64 | 3168 | 308783 | 583064 | 52454051 |
Abnormal dreams | 10.22 | 9.64 | 30 | 311921 | 10571 | 53026544 |
Autonomic dysreflexia | 10.22 | 9.64 | 11 | 311940 | 314 | 53036801 |
Pericardial effusion | 10.19 | 9.64 | 106 | 311845 | 27172 | 53009943 |
Vitamin D deficiency | 10.18 | 9.64 | 37 | 311914 | 12211 | 53024904 |
Immunodeficiency | 10.18 | 9.64 | 133 | 311818 | 14834 | 53022281 |
Bone density decreased | 10.17 | 9.64 | 32 | 311919 | 11032 | 53026083 |
Eructation | 10.16 | 9.64 | 19 | 311932 | 7836 | 53029279 |
Drug level below therapeutic | 10.12 | 9.64 | 46 | 311905 | 3687 | 53033428 |
General physical health deterioration | 10.11 | 9.64 | 731 | 311220 | 146211 | 52890904 |
Blood cholesterol increased | 10.05 | 9.64 | 392 | 311559 | 52597 | 52984518 |
Infusion site oedema | 10.03 | 9.64 | 14 | 311937 | 525 | 53036590 |
Complication of device removal | 10.02 | 9.64 | 6 | 311945 | 4176 | 53032939 |
Swelling face | 9.99 | 9.64 | 256 | 311695 | 56912 | 52980203 |
Hemiplegia | 9.97 | 9.64 | 19 | 311932 | 7781 | 53029334 |
Product preparation error | 9.94 | 9.64 | 7 | 311944 | 4468 | 53032647 |
Impaired gastric emptying | 9.92 | 9.64 | 24 | 311927 | 9019 | 53028096 |
Activated partial thromboplastin time prolonged | 9.90 | 9.64 | 73 | 311878 | 6986 | 53030129 |
Dysphonia | 9.89 | 9.64 | 179 | 311772 | 41759 | 52995356 |
Eczema | 9.86 | 9.64 | 92 | 311859 | 24090 | 53013025 |
Treatment noncompliance | 9.81 | 9.64 | 135 | 311816 | 32900 | 53004215 |
Renal disorder | 9.79 | 9.64 | 116 | 311835 | 29023 | 53008092 |
Decerebrate posture | 9.75 | 9.64 | 7 | 311944 | 114 | 53037001 |
Electrocardiogram QT prolonged | 9.74 | 9.64 | 253 | 311698 | 56150 | 52980965 |
Concomitant disease aggravated | 9.74 | 9.64 | 23 | 311928 | 8715 | 53028400 |
Corneal reflex decreased | 9.72 | 9.64 | 8 | 311943 | 161 | 53036954 |
Gastric infection | 9.72 | 9.64 | 40 | 311911 | 3070 | 53034045 |
Skin burning sensation | 9.70 | 9.64 | 35 | 311916 | 11575 | 53025540 |
Hypoxia | 9.66 | 9.64 | 408 | 311543 | 55272 | 52981843 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1230.98 | 10.25 | 1761 | 141380 | 90756 | 32279629 |
Toxicity to various agents | 1108.26 | 10.25 | 2426 | 140715 | 175615 | 32194770 |
Infusion related reaction | 401.27 | 10.25 | 720 | 142421 | 44879 | 32325506 |
Drug abuse | 341.31 | 10.25 | 947 | 142194 | 79296 | 32291089 |
Overdose | 314.11 | 10.25 | 969 | 142172 | 86108 | 32284277 |
Blood pressure fluctuation | 302.34 | 10.25 | 407 | 142734 | 19728 | 32350657 |
Intentional product misuse | 290.31 | 10.25 | 548 | 142593 | 35503 | 32334882 |
Acute hepatic failure | 243.47 | 10.25 | 293 | 142848 | 12676 | 32357709 |
Intentional overdose | 215.67 | 10.25 | 529 | 142612 | 41072 | 32329313 |
Drug ineffective | 184.23 | 10.25 | 967 | 142174 | 382510 | 31987875 |
Respiratory arrest | 150.21 | 10.25 | 368 | 142773 | 28540 | 32341845 |
Exposure to toxic agent | 119.87 | 10.25 | 69 | 143072 | 1019 | 32369366 |
Heart rate decreased | 118.60 | 10.25 | 309 | 142832 | 24891 | 32345494 |
Blood pressure increased | 104.49 | 10.25 | 652 | 142489 | 78702 | 32291683 |
Anion gap | 99.94 | 10.25 | 54 | 143087 | 700 | 32369685 |
Coagulopathy | 94.12 | 10.25 | 242 | 142899 | 19335 | 32351050 |
Cardio-respiratory arrest | 91.99 | 10.25 | 488 | 142653 | 55501 | 32314884 |
Oxygen saturation decreased | 90.81 | 10.25 | 436 | 142705 | 47663 | 32322722 |
Hepatotoxicity | 89.85 | 10.25 | 236 | 142905 | 19101 | 32351284 |
Metabolic acidosis | 85.76 | 10.25 | 381 | 142760 | 40318 | 32330067 |
Myocardial infarction | 85.61 | 10.25 | 276 | 142865 | 125400 | 32244985 |
Accidental overdose | 78.86 | 10.25 | 225 | 142916 | 19114 | 32351271 |
Poisoning | 75.75 | 10.25 | 158 | 142983 | 11000 | 32359385 |
Product dose omission issue | 75.75 | 10.25 | 217 | 142924 | 102358 | 32268027 |
Psoriasis | 68.77 | 10.25 | 61 | 143080 | 46062 | 32324323 |
Sinusitis | 68.70 | 10.25 | 331 | 142810 | 36229 | 32334156 |
Exposure via ingestion | 68.35 | 10.25 | 67 | 143074 | 2290 | 32368095 |
Drug resistance | 68.00 | 10.25 | 10 | 143131 | 22955 | 32347430 |
Respiratory depression | 67.35 | 10.25 | 167 | 142974 | 13044 | 32357341 |
Substance abuse | 67.31 | 10.25 | 116 | 143025 | 6991 | 32363394 |
Methaemoglobinaemia | 62.37 | 10.25 | 70 | 143071 | 2806 | 32367579 |
Hepatic necrosis | 60.63 | 10.25 | 81 | 143060 | 3894 | 32366491 |
Treatment failure | 60.57 | 10.25 | 50 | 143091 | 39113 | 32331272 |
Diarrhoea | 60.48 | 10.25 | 1188 | 141953 | 363614 | 32006771 |
Heart rate irregular | 54.71 | 10.25 | 161 | 142980 | 13917 | 32356468 |
Liver injury | 53.78 | 10.25 | 160 | 142981 | 13914 | 32356471 |
Alanine aminotransferase increased | 53.71 | 10.25 | 555 | 142586 | 77924 | 32292461 |
Cardiac failure | 53.32 | 10.25 | 215 | 142926 | 91458 | 32278927 |
Serotonin syndrome | 53.05 | 10.25 | 195 | 142946 | 18922 | 32351463 |
Hypotension | 47.70 | 10.25 | 1267 | 141874 | 214843 | 32155542 |
Hepatic cytolysis | 47.49 | 10.25 | 110 | 143031 | 8223 | 32362162 |
Cardiac arrest | 47.04 | 10.25 | 641 | 142500 | 96135 | 32274250 |
Aspartate aminotransferase increased | 46.98 | 10.25 | 473 | 142668 | 65956 | 32304429 |
Blood pressure diastolic abnormal | 46.71 | 10.25 | 54 | 143087 | 2236 | 32368149 |
Blood pressure systolic increased | 45.41 | 10.25 | 174 | 142967 | 17222 | 32353163 |
Chills | 45.09 | 10.25 | 534 | 142607 | 77550 | 32292835 |
Depressed level of consciousness | 44.32 | 10.25 | 320 | 142821 | 40527 | 32329858 |
Analgesic drug level increased | 43.74 | 10.25 | 30 | 143111 | 611 | 32369774 |
Intentional product use issue | 43.13 | 10.25 | 326 | 142815 | 41885 | 32328500 |
Anaemia | 39.79 | 10.25 | 719 | 142422 | 222905 | 32147480 |
Suicide attempt | 39.43 | 10.25 | 296 | 142845 | 37948 | 32332437 |
Product use in unapproved indication | 38.78 | 10.25 | 225 | 142916 | 86979 | 32283406 |
Medication error | 38.76 | 10.25 | 199 | 142942 | 22336 | 32348049 |
Infusion site extravasation | 38.68 | 10.25 | 57 | 143084 | 3004 | 32367381 |
Heart rate increased | 38.31 | 10.25 | 315 | 142826 | 41513 | 32328872 |
Contraindicated product administered | 38.27 | 10.25 | 18 | 143123 | 19058 | 32351327 |
Blood pressure diastolic increased | 37.20 | 10.25 | 61 | 143080 | 3529 | 32366856 |
Cardiac failure congestive | 37.16 | 10.25 | 220 | 142921 | 84632 | 32285753 |
Drug interaction | 36.49 | 10.25 | 709 | 142432 | 217476 | 32152909 |
Therapeutic product effect incomplete | 35.46 | 10.25 | 81 | 143060 | 41260 | 32329125 |
Foetal exposure during pregnancy | 35.37 | 10.25 | 81 | 143060 | 41220 | 32329165 |
Blood pressure systolic abnormal | 35.06 | 10.25 | 45 | 143096 | 2079 | 32368306 |
Suspected suicide | 33.49 | 10.25 | 53 | 143088 | 2975 | 32367410 |
Renal cortical necrosis | 33.48 | 10.25 | 16 | 143125 | 157 | 32370228 |
Coronary artery disease | 33.21 | 10.25 | 110 | 143031 | 49596 | 32320789 |
International normalised ratio increased | 33.16 | 10.25 | 346 | 142795 | 48689 | 32321696 |
Body temperature decreased | 32.82 | 10.25 | 115 | 143026 | 10899 | 32359486 |
Tachycardia | 32.55 | 10.25 | 509 | 142632 | 78579 | 32291806 |
Stevens-Johnson syndrome | 31.34 | 10.25 | 164 | 142977 | 18545 | 32351840 |
Nasopharyngitis | 31.18 | 10.25 | 423 | 142718 | 63364 | 32307021 |
Neutrophil percentage increased | 30.00 | 10.25 | 40 | 143101 | 1919 | 32368466 |
Anion gap abnormal | 29.60 | 10.25 | 14 | 143127 | 134 | 32370251 |
Bone marrow failure | 29.08 | 10.25 | 56 | 143085 | 30348 | 32340037 |
Blood pH decreased | 28.85 | 10.25 | 43 | 143098 | 2290 | 32368095 |
Sopor | 28.80 | 10.25 | 8 | 143133 | 11741 | 32358644 |
Infusion site pain | 28.62 | 10.25 | 49 | 143092 | 2937 | 32367448 |
Product prescribing error | 28.29 | 10.25 | 27 | 143114 | 19690 | 32350695 |
Blood pressure diastolic decreased | 27.67 | 10.25 | 82 | 143059 | 7115 | 32363270 |
Coma | 27.55 | 10.25 | 298 | 142843 | 42314 | 32328071 |
Unresponsive to stimuli | 27.51 | 10.25 | 212 | 142929 | 27397 | 32342988 |
Diabetes mellitus | 27.48 | 10.25 | 104 | 143037 | 45069 | 32325316 |
Infusion site pruritus | 26.92 | 10.25 | 23 | 143118 | 656 | 32369729 |
Hypoxia | 26.83 | 10.25 | 349 | 142792 | 51783 | 32318602 |
Neuropathy peripheral | 26.58 | 10.25 | 214 | 142927 | 76768 | 32293617 |
Urine sodium decreased | 26.15 | 10.25 | 14 | 143127 | 178 | 32370207 |
Therapeutic response shortened | 25.48 | 10.25 | 61 | 143080 | 4659 | 32365726 |
Depression | 24.96 | 10.25 | 290 | 142851 | 96770 | 32273615 |
Wrong technique in product usage process | 24.53 | 10.25 | 76 | 143065 | 34983 | 32335402 |
Ear infection | 24.13 | 10.25 | 87 | 143054 | 8361 | 32362024 |
Lymphocyte percentage decreased | 23.80 | 10.25 | 38 | 143103 | 2149 | 32368236 |
Hepatic failure | 23.75 | 10.25 | 251 | 142890 | 35429 | 32334956 |
Body temperature fluctuation | 23.64 | 10.25 | 31 | 143110 | 1463 | 32368922 |
Accidental exposure to product by child | 23.31 | 10.25 | 32 | 143109 | 1579 | 32368806 |
Toxic epidermal necrolysis | 23.30 | 10.25 | 163 | 142978 | 20430 | 32349955 |
General physical health deterioration | 22.91 | 10.25 | 363 | 142778 | 114896 | 32255489 |
Appendicolith | 22.88 | 10.25 | 46 | 143095 | 3119 | 32367266 |
Renal impairment | 22.80 | 10.25 | 277 | 142864 | 91695 | 32278690 |
Mydriasis | 22.50 | 10.25 | 71 | 143070 | 6375 | 32364010 |
Acute lung injury | 22.44 | 10.25 | 29 | 143112 | 1349 | 32369036 |
Psoriatic arthropathy | 21.73 | 10.25 | 28 | 143113 | 17832 | 32352553 |
Pyrexia | 21.59 | 10.25 | 1661 | 141480 | 318307 | 32052078 |
Respiratory rate increased | 21.54 | 10.25 | 90 | 143051 | 9267 | 32361118 |
Ductus arteriosus premature closure | 21.20 | 10.25 | 13 | 143128 | 217 | 32370168 |
Mental status changes | 20.72 | 10.25 | 259 | 142882 | 38078 | 32332307 |
Angina pectoris | 20.68 | 10.25 | 70 | 143071 | 31356 | 32339029 |
Glycosylated haemoglobin increased | 20.54 | 10.25 | 10 | 143131 | 10379 | 32360006 |
Cerebral haemorrhage | 20.49 | 10.25 | 81 | 143060 | 34666 | 32335719 |
Brain death | 20.41 | 10.25 | 39 | 143102 | 2547 | 32367838 |
Poor venous access | 20.32 | 10.25 | 43 | 143098 | 3023 | 32367362 |
Flushing | 20.27 | 10.25 | 218 | 142923 | 30909 | 32339476 |
Balance disorder | 20.22 | 10.25 | 97 | 143044 | 39362 | 32331023 |
Hepatocellular carcinoma | 20.13 | 10.25 | 10 | 143131 | 10260 | 32360125 |
Infusion site swelling | 20.01 | 10.25 | 32 | 143109 | 1812 | 32368573 |
Dizziness | 20.01 | 10.25 | 738 | 142403 | 208880 | 32161505 |
Hospitalisation | 19.86 | 10.25 | 130 | 143011 | 48841 | 32321544 |
Haemolysis | 19.85 | 10.25 | 77 | 143064 | 7664 | 32362721 |
Agitation | 19.74 | 10.25 | 358 | 142783 | 56878 | 32313507 |
Osteonecrosis | 19.27 | 10.25 | 27 | 143114 | 16595 | 32353790 |
Immune reconstitution inflammatory syndrome | 19.21 | 10.25 | 9 | 143132 | 9550 | 32360835 |
Progressive multifocal leukoencephalopathy | 19.11 | 10.25 | 9 | 143132 | 9522 | 32360863 |
Body temperature increased | 19.06 | 10.25 | 127 | 143014 | 15664 | 32354721 |
Graft versus host disease | 19.05 | 10.25 | 12 | 143129 | 10794 | 32359591 |
Throat tightness | 18.91 | 10.25 | 76 | 143065 | 7690 | 32362695 |
Urticaria | 18.88 | 10.25 | 368 | 142773 | 59246 | 32311139 |
Hepatitis C | 18.83 | 10.25 | 19 | 143122 | 13499 | 32356886 |
Blood triglycerides increased | 18.75 | 10.25 | 22 | 143119 | 14597 | 32355788 |
Chronic gastrointestinal bleeding | 18.57 | 10.25 | 13 | 143128 | 274 | 32370111 |
Cerebrovascular accident | 18.47 | 10.25 | 268 | 142873 | 86052 | 32284333 |
Asthma | 18.37 | 10.25 | 116 | 143025 | 43949 | 32326436 |
Prothrombin time prolonged | 18.08 | 10.25 | 88 | 143053 | 9667 | 32360718 |
Venoocclusive liver disease | 18.08 | 10.25 | 5 | 143136 | 7360 | 32363025 |
Infusion site erythema | 17.79 | 10.25 | 30 | 143111 | 1776 | 32368609 |
Granulomatosis with polyangiitis | 17.71 | 10.25 | 22 | 143119 | 983 | 32369402 |
Cytokine release syndrome | 17.65 | 10.25 | 111 | 143030 | 13424 | 32356961 |
Asthenia | 17.23 | 10.25 | 856 | 142285 | 235088 | 32135297 |
Environmental exposure | 17.22 | 10.25 | 12 | 143129 | 251 | 32370134 |
Disease progression | 17.11 | 10.25 | 274 | 142867 | 86588 | 32283797 |
Injection site pain | 17.09 | 10.25 | 81 | 143060 | 32977 | 32337408 |
Feeling abnormal | 16.93 | 10.25 | 177 | 142964 | 60246 | 32310139 |
Plasma cell myeloma | 16.88 | 10.25 | 167 | 142974 | 57447 | 32312938 |
Therapeutic response decreased | 16.87 | 10.25 | 58 | 143083 | 25862 | 32344523 |
Renal papillary necrosis | 16.78 | 10.25 | 10 | 143131 | 158 | 32370227 |
Acidosis | 16.75 | 10.25 | 93 | 143048 | 10753 | 32359632 |
Transaminases increased | 16.62 | 10.25 | 176 | 142965 | 24852 | 32345533 |
Cytomegalovirus infection | 16.56 | 10.25 | 57 | 143084 | 25407 | 32344978 |
Apparent life threatening event | 16.38 | 10.25 | 11 | 143130 | 216 | 32370169 |
Haematotoxicity | 15.90 | 10.25 | 5 | 143136 | 6771 | 32363614 |
Erythema multiforme | 15.87 | 10.25 | 80 | 143061 | 8912 | 32361473 |
Peritonitis bacterial | 15.82 | 10.25 | 19 | 143122 | 12477 | 32357908 |
Mycoplasma test positive | 15.81 | 10.25 | 9 | 143132 | 130 | 32370255 |
Oedema peripheral | 15.77 | 10.25 | 382 | 142759 | 113709 | 32256676 |
Oxygen saturation abnormal | 15.74 | 10.25 | 23 | 143118 | 1203 | 32369182 |
Fatigue | 15.72 | 10.25 | 1330 | 141811 | 349371 | 32021014 |
Pyroglutamic acidosis | 15.70 | 10.25 | 10 | 143131 | 179 | 32370206 |
Leukopenia | 15.70 | 10.25 | 179 | 142962 | 59943 | 32310442 |
Acute myocardial infarction | 15.68 | 10.25 | 161 | 142980 | 54988 | 32315397 |
Electrocardiogram QRS complex prolonged | 15.61 | 10.25 | 50 | 143091 | 4524 | 32365861 |
Myelosuppression | 15.60 | 10.25 | 17 | 143124 | 11659 | 32358726 |
Epilepsy | 15.41 | 10.25 | 48 | 143093 | 22061 | 32348324 |
Febrile neutropenia | 15.29 | 10.25 | 658 | 142483 | 118908 | 32251477 |
Pemphigus | 15.28 | 10.25 | 24 | 143117 | 1338 | 32369047 |
Cerebral infarction | 15.27 | 10.25 | 66 | 143075 | 27548 | 32342837 |
Administration site pain | 15.09 | 10.25 | 10 | 143131 | 192 | 32370193 |
Upper respiratory tract infection | 15.03 | 10.25 | 197 | 142944 | 29276 | 32341109 |
Bilirubin urine present | 15.01 | 10.25 | 9 | 143132 | 144 | 32370241 |
Pathogen resistance | 14.88 | 10.25 | 12 | 143129 | 9498 | 32360887 |
Myopathy | 14.62 | 10.25 | 17 | 143124 | 11324 | 32359061 |
Dissociative disorder | 14.56 | 10.25 | 10 | 143131 | 204 | 32370181 |
Throat irritation | 14.55 | 10.25 | 83 | 143058 | 9695 | 32360690 |
Osteonecrosis of jaw | 14.53 | 10.25 | 40 | 143101 | 19126 | 32351259 |
Abdominal pain | 14.53 | 10.25 | 801 | 142340 | 148728 | 32221657 |
Mucosal inflammation | 14.46 | 10.25 | 87 | 143054 | 33347 | 32337038 |
Anti-erythrocyte antibody positive | 14.41 | 10.25 | 6 | 143135 | 41 | 32370344 |
Post transplant lymphoproliferative disorder | 14.25 | 10.25 | 4 | 143137 | 5830 | 32364555 |
Haematocrit decreased | 13.87 | 10.25 | 206 | 142935 | 31456 | 32338929 |
Memory impairment | 13.75 | 10.25 | 113 | 143028 | 40366 | 32330019 |
Prescribed overdose | 13.69 | 10.25 | 13 | 143128 | 9506 | 32360879 |
Prostate cancer | 13.67 | 10.25 | 68 | 143073 | 27338 | 32343047 |
Ureteric obstruction | 13.63 | 10.25 | 22 | 143119 | 1256 | 32369129 |
Administration site erythema | 13.57 | 10.25 | 7 | 143134 | 82 | 32370303 |
Maple syrup disease | 13.36 | 10.25 | 4 | 143137 | 8 | 32370377 |
Burn of internal organs | 13.29 | 10.25 | 3 | 143138 | 0 | 32370385 |
Drug screen positive | 13.26 | 10.25 | 45 | 143096 | 4196 | 32366189 |
Hypoaesthesia | 13.25 | 10.25 | 179 | 142962 | 58174 | 32312211 |
Hangover | 13.22 | 10.25 | 20 | 143121 | 1079 | 32369306 |
Fluid retention | 13.17 | 10.25 | 66 | 143075 | 26484 | 32343901 |
Injection site haemorrhage | 13.04 | 10.25 | 11 | 143130 | 8517 | 32361868 |
Renal injury | 12.81 | 10.25 | 94 | 143047 | 11961 | 32358424 |
Visual acuity reduced | 12.71 | 10.25 | 34 | 143107 | 16411 | 32353974 |
Acid-base balance disorder mixed | 12.63 | 10.25 | 6 | 143135 | 58 | 32370327 |
Endocardial fibrosis | 12.55 | 10.25 | 5 | 143136 | 30 | 32370355 |
Myalgia | 12.33 | 10.25 | 268 | 142873 | 80962 | 32289423 |
Delirium | 12.33 | 10.25 | 267 | 142874 | 43779 | 32326606 |
Crystal urine present | 12.29 | 10.25 | 12 | 143129 | 408 | 32369977 |
Therapeutic product effect decreased | 12.24 | 10.25 | 83 | 143058 | 30934 | 32339451 |
Anion gap increased | 12.22 | 10.25 | 25 | 143116 | 1716 | 32368669 |
Pancytopenia | 12.18 | 10.25 | 307 | 142834 | 90928 | 32279457 |
Product substitution issue | 12.05 | 10.25 | 17 | 143124 | 10419 | 32359966 |
Infusion site bruising | 12.00 | 10.25 | 11 | 143130 | 345 | 32370040 |
Prostatic specific antigen increased | 12.00 | 10.25 | 25 | 143116 | 13162 | 32357223 |
Sudden infant death syndrome | 11.92 | 10.25 | 8 | 143133 | 157 | 32370228 |
Death | 11.91 | 10.25 | 1887 | 141254 | 380630 | 31989755 |
Aplastic anaemia | 11.91 | 10.25 | 64 | 143077 | 7309 | 32363076 |
Erectile dysfunction | 11.85 | 10.25 | 46 | 143095 | 19793 | 32350592 |
Pneumonia aspiration | 11.69 | 10.25 | 250 | 142891 | 40906 | 32329479 |
Bacterial test | 11.45 | 10.25 | 8 | 143133 | 168 | 32370217 |
Inadequate analgesia | 11.37 | 10.25 | 33 | 143108 | 2830 | 32367555 |
Tendonitis | 11.36 | 10.25 | 13 | 143128 | 8722 | 32361663 |
Labelled drug-drug interaction issue | 11.35 | 10.25 | 7 | 143134 | 118 | 32370267 |
Drug ineffective for unapproved indication | 11.34 | 10.25 | 28 | 143113 | 13884 | 32356501 |
Hypertriglyceridaemia | 11.31 | 10.25 | 13 | 143128 | 8706 | 32361679 |
C-reactive protein abnormal | 11.28 | 10.25 | 7 | 143134 | 6349 | 32364036 |
Polyneuropathy | 11.24 | 10.25 | 26 | 143115 | 13189 | 32357196 |
Bronchial dysplasia | 11.23 | 10.25 | 5 | 143136 | 41 | 32370344 |
Cerebral artery thrombosis | 11.18 | 10.25 | 14 | 143127 | 631 | 32369754 |
Urobilinogen urine increased | 11.15 | 10.25 | 11 | 143130 | 379 | 32370006 |
Diabetic ketoacidosis | 11.09 | 10.25 | 41 | 143100 | 17891 | 32352494 |
Tooth infection | 11.08 | 10.25 | 53 | 143088 | 5781 | 32364604 |
Brain oedema | 11.01 | 10.25 | 96 | 143045 | 12864 | 32357521 |
Monocyte percentage increased | 10.98 | 10.25 | 17 | 143124 | 936 | 32369449 |
Brain scan abnormal | 10.94 | 10.25 | 15 | 143126 | 739 | 32369646 |
Administration site swelling | 10.90 | 10.25 | 8 | 143133 | 182 | 32370203 |
Infusion site nodule | 10.83 | 10.25 | 6 | 143135 | 82 | 32370303 |
Hyperchloraemia | 10.81 | 10.25 | 12 | 143129 | 475 | 32369910 |
Leukocytosis | 10.80 | 10.25 | 154 | 142987 | 23313 | 32347072 |
Ultrasound liver abnormal | 10.76 | 10.25 | 7 | 143134 | 130 | 32370255 |
Vessel puncture site bruise | 10.74 | 10.25 | 5 | 143136 | 46 | 32370339 |
Pupillary light reflex tests abnormal | 10.72 | 10.25 | 7 | 143134 | 131 | 32370254 |
Red blood cell elliptocytes present | 10.64 | 10.25 | 6 | 143135 | 85 | 32370300 |
Bladder cancer | 10.60 | 10.25 | 18 | 143123 | 10238 | 32360147 |
Interstitial lung disease | 10.59 | 10.25 | 212 | 142929 | 64789 | 32305596 |
Liver transplant | 10.58 | 10.25 | 32 | 143109 | 2808 | 32367577 |
Wrong product administered | 10.57 | 10.25 | 47 | 143094 | 4973 | 32365412 |
Analgesic drug level above therapeutic | 10.56 | 10.25 | 9 | 143132 | 256 | 32370129 |
Blood ethanol increased | 10.55 | 10.25 | 11 | 143130 | 405 | 32369980 |
Gynaecomastia | 10.55 | 10.25 | 14 | 143127 | 8805 | 32361580 |
Loss of personal independence in daily activities | 10.49 | 10.25 | 72 | 143069 | 26761 | 32343624 |
Gait inability | 10.43 | 10.25 | 49 | 143092 | 19998 | 32350387 |
Hallucinations, mixed | 10.41 | 10.25 | 31 | 143110 | 2696 | 32367689 |
Cardiac disorder | 10.40 | 10.25 | 126 | 143015 | 41740 | 32328645 |
Intraocular pressure increased | 10.37 | 10.25 | 6 | 143135 | 5652 | 32364733 |
Sputum culture positive | 10.36 | 10.25 | 25 | 143116 | 1919 | 32368466 |
Source | Code | Description |
---|---|---|
ATC | N07XX59 | NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS OTHER NERVOUS SYSTEM DRUGS Other nervous system drugs |
ATC | R05DA09 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:50910 | agente neurotoxico |
CHEBI has role | CHEBI:51177 | cough suppressant |
CHEBI has role | CHEBI:60643 | N-methyl-D-aspartate receptor antagonists |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:146270 | oneirogens |
MeSH PA | D000996 | Antitussive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D018691 | Excitatory Amino Acid Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D019141 | Respiratory System Agents |
FDA MoA | N0000181819 | Uncompetitive NMDA Receptor Antagonists |
FDA EPC | N0000181821 | Uncompetitive N-methyl-D-aspartate Receptor Antagonist |
FDA MoA | N0000182147 | Sigma-1 Receptor Agonists |
FDA EPC | N0000182149 | Sigma-1 Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Cough | indication | 49727002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Rhinitis | indication | 70076002 | DOID:4483 |
Sneezing | indication | 76067001 | |
Common cold | indication | 82272006 | DOID:10459 |
Headache disorder | indication | 230461009 | |
Sore throat symptom | indication | 267102003 | |
Influenza-like symptoms | indication | 315642008 | |
Fever | indication | 386661006 | |
Pseudobulbar affect | indication | 432776007 | |
Mouth Irritation | indication | ||
Opioid withdrawal | off-label use | 87132004 | |
Neurotoxicity caused by methotrexate | off-label use | 129666005 | |
Metabolic alkalosis | contraindication | 1388004 | |
Brain damage | contraindication | 2470005 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Goiter | contraindication | 3716002 | DOID:12176 |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Hypocalcemia | contraindication | 5291005 | |
Tachyarrhythmia | contraindication | 6285003 | |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Asthenia | contraindication | 13791008 | |
Hyperkalemia | contraindication | 14140009 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Hyperbilirubinemia | contraindication | 14783006 | DOID:2741 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Mood swings | contraindication | 18963009 | |
Pulmonary edema | contraindication | 19242006 | DOID:11396 |
Lowered convulsive threshold | contraindication | 19260006 | |
Hashimoto thyroiditis | contraindication | 21983002 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Disorder of the central nervous system | contraindication | 23853001 | DOID:331 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Acute tuberculosis | contraindication | 25629007 | |
Alcohol intoxication | contraindication | 25702006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Torsades de pointes | contraindication | 31722008 | |
Bronchitis | contraindication | 32398004 | DOID:6132 |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Methemoglobinemia | contraindication | 38959009 | DOID:10783 |
Hypernatremia | contraindication | 39355002 | |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Acidosis | contraindication | 51387008 | |
Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Left ventricular hypertrophy | contraindication | 55827005 | |
Peptic reflux disease | contraindication | 57643001 | |
Acute nephropathy | contraindication | 58574008 | |
Metabolic acidosis | contraindication | 59455009 | |
Hepatic failure | contraindication | 59927004 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Poisoning by acetaminophen | contraindication | 70273001 | |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Urethral stricture | contraindication | 76618002 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Disorder of brain | contraindication | 81308009 | DOID:936 |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Oliguria | contraindication | 83128009 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Left heart failure | contraindication | 85232009 | |
Pulmonary emphysema | contraindication | 87433001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Dermatitis herpetiformis | contraindication | 111196000 | DOID:8505 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
Acute abdominal pain | contraindication | 116290004 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Hypomagnesemia | contraindication | 190855004 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Partial atrioventricular block | contraindication | 195039008 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Hypocomplementemic urticarial vasculitis | contraindication | 239945009 | |
Rhabdomyolysis | contraindication | 240131006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Drowsy | contraindication | 271782001 | |
Peripheral edema | contraindication | 271809000 | |
Exacerbation of asthma | contraindication | 281239006 | |
Pregnancy, function | contraindication | 289908002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
Bone marrow depression | contraindication | 307762000 | |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Traumatic injury | contraindication | 417746004 | |
Central nervous system depression | contraindication | 418072004 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Hypertensive urgency | contraindication | 443482000 | |
Azotemia | contraindication | 445009001 | |
Severe dehydration | contraindication | 450316000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.55 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
20MG;10MG | NUEDEXTA | AVANIR PHARMS | N021879 | Oct. 29, 2010 | RX | CAPSULE | ORAL | 8227484 | July 17, 2023 | TREATMENT OF PSEUDOBULBAR AFFECT |
20MG;10MG | NUEDEXTA | AVANIR PHARMS | N021879 | Oct. 29, 2010 | RX | CAPSULE | ORAL | 7659282 | Aug. 13, 2026 | TREATMENT OF PSEUDOBULBAR AFFECT |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sigma non-opioid intracellular receptor 1 | Membrane receptor | AGONIST | D2 | 6.46 | WOMBAT-PK | ||||
Sodium-dependent serotonin transporter | Transporter | Ki | 8.84 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | Ks | 4.48 | WOMBAT-PK | |||||
Glutamate receptor ionotropic, NMDA 3A | Ion channel | ANTAGONIST | IC50 | 5.70 | WOMBAT-PK | ||||
Glutamate receptor ionotropic, NMDA 2C | Ion channel | BLOCKER | IC50 | 6.33 | IUPHAR | ||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.98 | CHEMBL | |||||
Taste receptor type 2 member 46 | GPCR | EC50 | 4.51 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.29 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane other | IC50 | 7.82 | CHEMBL | |||||
Glutamate NMDA receptor | Ion channel | Ki | 5.65 | CHEMBL | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.89 | CHEMBL |
ID | Source |
---|---|
4020116 | VUID |
N0000179729 | NUI |
D00848 | KEGG_DRUG |
18609-21-7 | SECONDARY_CAS_RN |
4018051 | VANDF |
4018052 | VANDF |
4020116 | VANDF |
C0011816 | UMLSCUI |
CHEBI:4470 | CHEBI |
CHEMBL52440 | ChEMBL_ID |
CHEMBL1256818 | ChEMBL_ID |
CHEMBL1201004 | ChEMBL_ID |
DB00514 | DRUGBANK_ID |
D003915 | MESH_DESCRIPTOR_UI |
5360696 | PUBCHEM_CID |
6953 | IUPHAR_LIGAND_ID |
166 | INN_ID |
7355X3ROTS | UNII |
102490 | RXNORM |
18766 | MMSL |
44093 | MMSL |
4565 | MMSL |
4566 | MMSL |
73044 | MMSL |
d00207 | MMSL |
001653 | NDDF |
004427 | NDDF |
005215 | NDDF |
2016004 | SNOMEDCT_US |
387114001 | SNOMEDCT_US |
387237004 | SNOMEDCT_US |
CHEMBL1201461 | ChEMBL_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-2097 | SOLUTION | 20 mg | ORAL | OTC monograph final | 15 sections |
Childrens Robitussin Elderberry Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-2098 | SOLUTION | 20 mg | ORAL | OTC monograph final | 15 sections |
CHILDRENS DIMETAPP COLD AND COUGH | HUMAN OTC DRUG LABEL | 3 | 0031-2234 | LIQUID | 5 mg | ORAL | OTC monograph final | 16 sections |
Robitussin Tos Seca | HUMAN OTC DRUG LABEL | 1 | 0031-8652 | SYRUP | 10 mg | ORAL | Export only | 1 sections |
Robitussin 12 Hour Cough Relief | HUMAN OTC DRUG LABEL | 1 | 0031-8655 | SUSPENSION, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
Robitussin CF | HUMAN OTC DRUG LABEL | 3 | 0031-8678 | LIQUID | 10 mg | ORAL | Export only | 15 sections |
Childrens Robitussin Nighttime Cough Long-Acting DM | HUMAN OTC DRUG LABEL | 2 | 0031-8692 | SOLUTION | 15 mg | ORAL | OTC monograph final | 17 sections |
CHILDRENS ROBITUSSIN COUGH AND COLD LONG-ACTING | HUMAN OTC DRUG LABEL | 2 | 0031-8693 | LIQUID | 7.50 mg | ORAL | OTC monograph final | 17 sections |
Childrens Robitussin Cough Long-Acting | HUMAN OTC DRUG LABEL | 1 | 0031-8694 | LIQUID | 7.50 mg | ORAL | OTC monograph final | 14 sections |
Childrens Robitussin Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8702 | LIQUID | 20 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Childrens Robitussin Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8715 | LIQUID | 5 mg | ORAL | OTC monograph final | 15 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 5 mg | ORAL | OTC monograph final | 16 sections |
Robitussin Maximum Strength Nighttime Cough DM | HUMAN OTC DRUG LABEL | 2 | 0031-8718 | SOLUTION | 30 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Maximum Strength Cough Plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8719 | CAPSULE, LIQUID FILLED | 10 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Childrens Robitussin 12 Hour Cough Relief | HUMAN OTC DRUG LABEL | 1 | 0031-8725 | SUSPENSION, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
Childrens Robitussin 12 Hour Cough Relief | HUMAN OTC DRUG LABEL | 1 | 0031-8726 | SUSPENSION, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM | HUMAN OTC DRUG LABEL | 2 | 0031-8739 | SOLUTION | 20 mg | ORAL | OTC monograph final | 15 sections |
ROBITUSSIN LINGERING COLD LONG-ACTING COUGHGELS | HUMAN OTC DRUG LABEL | 1 | 0031-8741 | CAPSULE, LIQUID FILLED | 15 mg | ORAL | OTC monograph final | 14 sections |
Robitussin Peak Cold Multi-Symptom Cold | HUMAN OTC DRUG LABEL | 3 | 0031-8742 | LIQUID | 10 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
ROBITUSSIN LONG-ACTING COUGHGELS | HUMAN OTC DRUG LABEL | 1 | 0031-8743 | CAPSULE, LIQUID FILLED | 15 mg | ORAL | OTC MONOGRAPH FINAL | 15 sections |
Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime | HUMAN OTC DRUG LABEL | 3 | 0031-8744 | CAPSULE, LIQUID FILLED | 15 mg | ORAL | OTC MONOGRAPH FINAL | 17 sections |
Robitussin Maximum Strength Severe Cough Plus Sore Throat | HUMAN OTC DRUG LABEL | 2 | 0031-8750 | LIQUID | 20 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Severe Multi-Symptom Cough Cold Flu | HUMAN OTC DRUG LABEL | 4 | 0031-8751 | LIQUID | 20 mg | ORAL | OTC monograph final | 17 sections |
Robitussin 12 Hour Cough Relief | HUMAN OTC DRUG LABEL | 1 | 0031-8753 | SUSPENSION, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
Robitussin 12 Hour Cough Relief | HUMAN OTC DRUG LABEL | 1 | 0031-8754 | SUSPENSION, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
Robitussin 12 Hour Cough Relief | HUMAN OTC DRUG LABEL | 1 | 0031-8755 | SUSPENSION, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
Robitussin Honey Maximum Strength Cough and Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8756 | SOLUTION | 20 mg | ORAL | OTC monograph final | 15 sections |
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM | HUMAN OTC DRUG LABEL | 2 | 0031-8757 | SOLUTION | 20 mg | ORAL | OTC monograph final | 15 sections |
Robitussin Honey Maximum Strength Nighttime Cough DM | HUMAN OTC DRUG LABEL | 2 | 0031-8758 | SOLUTION | 30 mg | ORAL | OTC monograph final | 17 sections |
Robitussin Sugar-Free Dye-Free Cough Plus Chest Congestion DM | HUMAN OTC DRUG LABEL | 2 | 0031-8759 | SOLUTION | 20 mg | ORAL | OTC monograph final | 15 sections |