dextromethorphan Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor antagonists/agonists, morphinan derivates 842 125-71-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dextromethorphan HBr
  • dextromethorphan hydrochloride
  • dextromethorphan hydrobromide hydrate
  • dextromethorphan
  • (+)-Dextromethorphan
  • d-Methorphan
  • dextromethorphan hydrobromide
  • dextromethorphan hydriodide
  • dextromethorphan hydrobromide monohydrate
  • dextromethorphan polistirex
Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
  • Molecular weight: 271.40
  • Formula: C18H25NO
  • CLOGP: 3.95
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -4.50
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
90 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 15 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.19 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.88 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 11 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 3, 1957 FDA ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2739.62 9.55 3448 222713 142472 46317429
Toxicity to various agents 2284.11 9.55 3849 222312 207917 46251984
Infusion related reaction 658.71 9.55 1490 224671 99718 46360183
Overdose 502.79 9.55 1350 224811 100629 46359272
Intentional product misuse 427.16 9.55 796 225365 46332 46413569
Acute hepatic failure 405.22 9.55 425 225736 14296 46445605
Metabolic acidosis 332.80 9.55 640 225521 38140 46421761
Blood pressure fluctuation 321.71 9.55 550 225611 29898 46430003
Sinusitis 291.16 9.55 1323 224838 128445 46331456
Hepatotoxicity 273.80 9.55 459 225702 24550 46435351
Exposure to toxic agent 253.43 9.55 144 226017 1870 46458031
Product dose omission issue 238.45 9.55 279 225882 168241 46291660
Anion gap 215.82 9.55 105 226056 968 46458933
Respiratory arrest 213.13 9.55 492 225669 33324 46426577
Cardio-respiratory arrest 206.30 9.55 699 225462 59170 46400731
Intentional overdose 191.91 9.55 721 225440 64223 46395678
Injection site pain 175.83 9.55 156 226005 106996 46352905
Coagulopathy 148.58 9.55 297 225864 18202 46441699
Drug abuse 142.41 9.55 647 225514 62761 46397140
Psoriasis 138.12 9.55 107 226054 78497 46381404
Poisoning 128.75 9.55 238 225923 13756 46446145
Depressed level of consciousness 117.91 9.55 500 225661 47069 46412832
Heart rate decreased 115.11 9.55 377 225784 31346 46428555
Device expulsion 112.04 9.55 5 226156 27537 46432364
Oxygen saturation decreased 109.46 9.55 640 225521 68524 46391377
Hepatic failure 106.25 9.55 380 225781 33036 46426865
Blood pressure increased 104.80 9.55 1005 225156 125661 46334240
Respiratory depression 102.61 9.55 194 225967 11406 46448495
Blood pressure diastolic abnormal 102.39 9.55 139 226022 6155 46453746
Diarrhoea 101.31 9.55 2008 224153 557594 45902307
Drug ineffective 100.62 9.55 2510 223651 675328 45784573
Death 97.93 9.55 2219 223942 333329 46126572
Hepatic necrosis 94.63 9.55 126 226035 5475 46454426
Acute lung injury 92.01 9.55 64 226097 1207 46458694
Exposure via ingestion 91.67 9.55 98 226063 3369 46456532
Cardiac arrest 91.13 9.55 749 225412 89650 46370251
Injection site erythema 90.13 9.55 138 226023 74289 46385612
Intentional product use issue 89.81 9.55 498 225663 52282 46407619
Infusion site pain 89.36 9.55 169 225992 9938 46449963
Blood pressure diastolic decreased 83.25 9.55 201 225960 14010 46445891
Medication error 82.16 9.55 332 225829 30579 46429322
Injection site reaction 80.46 9.55 68 226093 47781 46412120
Body temperature increased 78.42 9.55 282 225879 24579 46435322
Nasopharyngitis 78.19 9.55 1112 225049 152886 46307015
Blood pressure systolic abnormal 78.11 9.55 114 226047 5403 46454498
Alopecia 76.94 9.55 466 225695 161948 46297953
Joint swelling 74.14 9.55 1173 224988 164900 46295001
Blood pressure systolic increased 73.99 9.55 306 225855 28481 46431420
Infusion site swelling 73.87 9.55 113 226048 5586 46454315
Wrong technique in product usage process 73.80 9.55 93 226068 54329 46405572
Coma 73.76 9.55 510 225651 57839 46402062
Accidental overdose 73.26 9.55 239 225922 19827 46440074
Heart rate increased 72.86 9.55 615 225546 74176 46385725
Pyroglutamate increased 71.62 9.55 37 226124 392 46459509
Injection site pruritus 71.20 9.55 53 226108 39690 46420211
International normalised ratio increased 70.41 9.55 428 225733 46455 46413446
Throat irritation 69.46 9.55 301 225860 28600 46431301
Infusion site erythema 67.83 9.55 128 226033 7514 46452387
Suspected suicide 66.99 9.55 97 226064 4564 46455337
Liver injury 66.17 9.55 199 225962 15802 46444099
Alanine aminotransferase increased 65.95 9.55 687 225474 87764 46372137
Hypotension 65.19 9.55 1530 224631 231059 46228842
Psoriatic arthropathy 64.55 9.55 49 226112 36330 46423571
Analgesic drug level increased 63.79 9.55 55 226106 1439 46458462
Injection site bruising 63.23 9.55 48 226113 35588 46424313
Sopor 61.23 9.55 11 226150 19817 46440084
Muscle injury 56.86 9.55 92 226069 4774 46455127
Suicide attempt 56.51 9.55 458 225703 54578 46405323
Infusion site extravasation 54.25 9.55 94 226067 5162 46454739
Hepatic enzyme increased 53.95 9.55 620 225541 81167 46378734
Product quality issue 53.66 9.55 56 226105 35592 46424309
Osteonecrosis of jaw 52.96 9.55 53 226108 34349 46425552
Disease progression 52.65 9.55 245 225916 91055 46368846
Anion gap abnormal 52.44 9.55 28 226133 319 46459582
Folliculitis 51.50 9.55 101 226060 6102 46453799
Soft tissue disorder 51.46 9.55 81 226080 4105 46455796
Paraesthesia 51.46 9.55 345 225816 117092 46342809
Aspartate aminotransferase increased 51.19 9.55 595 225566 78105 46381796
Crystal urine present 51.04 9.55 45 226116 1214 46458687
Ill-defined disorder 50.99 9.55 261 225900 26566 46433335
Electric shock 50.55 9.55 39 226122 868 46459033
Methaemoglobinaemia 50.05 9.55 57 226104 2105 46457796
Heart rate irregular 49.66 9.55 200 225961 18391 46441510
Anaemia 49.35 9.55 907 225254 254872 46205029
Hospitalisation 48.94 9.55 151 226010 63234 46396667
Drug resistance 48.78 9.55 12 226149 17356 46442545
Ear pain 48.50 9.55 224 225937 21868 46438033
Infusion site pruritus 47.59 9.55 67 226094 3071 46456830
White blood cells urine positive 45.86 9.55 76 226085 4024 46455877
Injection site swelling 45.77 9.55 78 226083 40249 46419652
Mucosal inflammation 45.53 9.55 74 226087 38902 46420999
Product prescribing error 45.52 9.55 20 226141 20027 46439874
No adverse event 44.85 9.55 60 226101 34171 46425730
Unresponsive to stimuli 44.73 9.55 288 225873 31886 46428015
Sedation complication 44.08 9.55 70 226091 3575 46456326
Dyspnoea 43.37 9.55 2049 224112 513499 45946402
Product substitution issue 42.97 9.55 10 226151 15021 46444880
Therapy cessation 42.18 9.55 40 226121 26589 46433312
Administration site swelling 42.04 9.55 39 226122 1126 46458775
Substance abuse 41.03 9.55 73 226088 4094 46455807
Urinary sediment present 40.48 9.55 47 226114 1773 46458128
Injection site warmth 39.69 9.55 9 226152 13763 46446138
Lower respiratory tract infection 38.30 9.55 422 225739 54667 46405234
Prothrombin time prolonged 37.49 9.55 117 226044 9479 46450422
Administration site pain 37.49 9.55 29 226132 648 46459253
Neutropenia 37.05 9.55 480 225681 142724 46317177
Myocardial infarction 36.73 9.55 299 225862 97229 46362672
Toxicologic test abnormal 36.67 9.55 29 226132 670 46459231
Cardiac failure congestive 36.55 9.55 277 225884 91473 46368428
Respiratory rate increased 36.32 9.55 130 226031 11303 46448598
Muscle spasticity 36.27 9.55 130 226031 11310 46448591
Blood pressure diastolic increased 35.53 9.55 85 226076 5889 46454012
Neuropathy peripheral 35.46 9.55 276 225885 90617 46369284
Product storage error 35.43 9.55 7 226154 11785 46448116
Infusion site nodule 35.33 9.55 33 226128 961 46458940
Body temperature decreased 34.81 9.55 143 226018 13266 46446635
Urine abnormality 34.80 9.55 81 226080 5513 46454388
Red blood cells urine positive 34.23 9.55 52 226109 2555 46457346
Drug hypersensitivity 33.99 9.55 910 225251 242915 46216986
Acidosis 33.76 9.55 125 226036 11049 46448852
Jaundice cholestatic 33.70 9.55 75 226086 4954 46454947
Product use in unapproved indication 33.43 9.55 278 225883 89995 46369906
Palmar-plantar erythrodysaesthesia syndrome 33.24 9.55 30 226131 20421 46439480
Cerebrovascular accident 33.11 9.55 321 225840 100718 46359183
Device malfunction 32.56 9.55 12 226149 13362 46446539
Creatinine renal clearance decreased 32.41 9.55 90 226071 6830 46453071
Bone marrow failure 32.21 9.55 59 226102 29610 46430291
Body temperature fluctuation 32.20 9.55 42 226119 1788 46458113
Device dislocation 31.97 9.55 35 226126 21767 46438134
Lymphocyte count decreased 31.93 9.55 223 225938 25366 46434535
Infusion site bruising 31.61 9.55 38 226123 1488 46458413
Abortion spontaneous 31.58 9.55 107 226054 43539 46416362
Liver transplant 31.43 9.55 48 226113 2369 46457532
Decreased appetite 31.20 9.55 708 225453 193128 46266773
Brain death 31.13 9.55 52 226109 2771 46457130
Muscle spasms 30.98 9.55 415 225746 122698 46337203
Hypothermia 30.90 9.55 129 226032 12054 46447847
Injection site urticaria 30.40 9.55 10 226151 11957 46447944
Foetal exposure during pregnancy 30.07 9.55 65 226096 30682 46429219
Maternal exposure during pregnancy 29.84 9.55 335 225826 102214 46357687
Feeling abnormal 29.18 9.55 428 225733 124632 46335269
Accidental death 29.05 9.55 40 226121 1795 46458106
Postmortem blood drug level increased 28.96 9.55 21 226140 424 46459477
Hypomania 28.91 9.55 65 226096 4323 46455578
Brain oedema 28.49 9.55 128 226033 12350 46447551
Fracture 28.19 9.55 23 226138 16448 46443453
Analgesic drug level above therapeutic 27.57 9.55 15 226146 178 46459723
Ear pruritus 27.43 9.55 42 226119 2078 46457823
Drug screen positive 27.18 9.55 59 226102 3832 46456069
Injection site mass 27.01 9.55 20 226141 15020 46444881
Intervertebral discitis 26.98 9.55 46 226115 2493 46457408
Haemolysis 26.62 9.55 77 226084 5982 46453919
Anti-cyclic citrullinated peptide antibody positive 26.38 9.55 171 225990 18974 46440927
Neutrophil percentage increased 26.36 9.55 47 226114 2640 46457261
Injection site rash 25.94 9.55 23 226138 15790 46444111
Helicobacter infection 25.76 9.55 119 226042 11617 46448284
Red cell distribution width increased 25.68 9.55 89 226072 7615 46452286
Surgery 25.61 9.55 64 226097 28721 46431180
Cardiac failure 25.35 9.55 256 225905 79692 46380209
Lymphocyte percentage decreased 24.94 9.55 46 226115 2653 46457248
Nausea 24.79 9.55 2935 223226 684519 45775382
Injection site haemorrhage 24.48 9.55 39 226122 20670 46439231
Anion gap increased 24.36 9.55 33 226128 1458 46458443
Sleep disorder due to general medical condition, insomnia type 24.32 9.55 68 226093 5181 46454720
Poor venous access 24.32 9.55 92 226069 8216 46451685
Irritable bowel syndrome 24.30 9.55 150 226011 16365 46443536
Pneumonia streptococcal 23.96 9.55 35 226126 1660 46458241
Duodenal ulcer perforation 23.94 9.55 93 226068 8409 46451492
Administration site erythema 23.86 9.55 21 226140 565 46459336
Dizziness 23.77 9.55 1378 224783 339036 46120865
Bone pain 23.52 9.55 132 226029 46758 46413143
Hypertensive crisis 23.31 9.55 19 226142 13596 46446305
Blood pH decreased 23.31 9.55 44 226117 2583 46457318
Myelodysplastic syndrome 23.28 9.55 25 226136 15686 46444215
Device issue 23.27 9.55 38 226123 19942 46439959
Urine leukocyte esterase positive 23.17 9.55 43 226118 2492 46457409
Off label use 22.99 9.55 1558 224603 378283 46081618
Blood creatine increased 22.80 9.55 61 226100 4529 46455372
Hyperkalaemia 22.68 9.55 148 226013 50561 46409340
Opiates positive 22.65 9.55 15 226146 260 46459641
Adverse event 22.61 9.55 87 226074 34097 46425804
Bacterial test 22.61 9.55 29 226132 1214 46458687
Pneumonia viral 22.49 9.55 77 226084 6547 46453354
Neoplasm progression 22.46 9.55 61 226100 26622 46433279
Blood bilirubin increased 22.46 9.55 259 225902 33925 46425976
Bradypnoea 22.28 9.55 47 226114 2992 46456909
Red blood cell sedimentation rate abnormal 22.21 9.55 20 226141 13629 46446272
Transient ischaemic attack 21.72 9.55 91 226070 34812 46425089
Blood calcium decreased 21.60 9.55 140 226021 15533 46444368
Polyneuropathy 21.54 9.55 15 226146 11629 46448272
Therapeutic product effect incomplete 21.30 9.55 259 225902 77894 46382007
Therapeutic product effect decreased 21.16 9.55 537 225624 82064 46377837
Pyroglutamic acidosis 21.12 9.55 14 226147 243 46459658
Blood urine present 20.95 9.55 116 226045 12166 46447735
Diabetes mellitus 20.48 9.55 150 226011 49915 46409986
Posterior reversible encephalopathy syndrome 20.39 9.55 26 226135 15115 46444786
Specific gravity urine decreased 20.26 9.55 17 226144 428 46459473
Hyponatraemia 20.23 9.55 357 225804 100975 46358926
Asphyxia 19.95 9.55 64 226097 5262 46454639
Epistaxis 19.93 9.55 207 225954 64098 46395803
Upper respiratory tract infection 19.92 9.55 425 225736 63131 46396770
Ductus arteriosus premature closure 19.78 9.55 15 226146 325 46459576
Osmolar gap 19.77 9.55 10 226151 101 46459800
Band neutrophil count increased 19.71 9.55 15 226146 327 46459574
Infusion site urticaria 19.59 9.55 21 226140 724 46459177
Drug interaction 19.49 9.55 795 225366 202299 46257602
Transaminases increased 19.45 9.55 213 225948 27548 46432353
Encephalopathy 19.25 9.55 248 225913 33341 46426560
Labelled drug-drug interaction medication error 19.11 9.55 10 226151 9051 46450850
Necrosis ischaemic 19.09 9.55 22 226139 823 46459078
Malignant neoplasm progression 18.92 9.55 212 225949 64714 46395187
Pancytopenia 18.84 9.55 294 225867 84764 46375137
Epilepsy 18.71 9.55 56 226105 23682 46436219
Therapy interrupted 18.55 9.55 15 226146 10776 46449125
Smear cervix abnormal 18.55 9.55 39 226122 2477 46457424
Oedema peripheral 18.50 9.55 611 225550 159095 46300806
Injection site induration 18.44 9.55 8 226153 8071 46451830
Gestational diabetes 18.40 9.55 6 226155 7213 46452688
Abdominal discomfort 18.31 9.55 575 225586 150590 46309311
Activated partial thromboplastin time prolonged 18.31 9.55 74 226087 6815 46453086
Ear infection 18.21 9.55 181 225980 22832 46437069
Dysgeusia 18.20 9.55 118 226043 40373 46419528
Device difficult to use 18.15 9.55 8 226153 7996 46451905
Haematocrit decreased 18.09 9.55 254 225907 34803 46425098
Respiratory disorder 18.00 9.55 207 225954 27093 46432808
Serotonin syndrome 17.98 9.55 188 225973 24032 46435869
Tachycardia 17.97 9.55 620 225541 99002 46360899
Somnolence 17.79 9.55 928 225233 155593 46304308
Bone erosion 17.69 9.55 12 226149 9431 46450470
Second primary malignancy 17.63 9.55 5 226156 6579 46453322
Memory impairment 17.57 9.55 266 225895 77071 46382830
Weight increased 17.47 9.55 969 225192 163504 46296397
Hyperlipidaemia 17.46 9.55 40 226121 18499 46441402
Fall 17.45 9.55 1365 224796 327732 46132169
Interstitial lung disease 16.99 9.55 173 225988 53776 46406125
Pericarditis 16.95 9.55 184 225977 23743 46436158
Vision blurred 16.82 9.55 278 225883 79430 46380471
Antidepressant drug level above therapeutic 16.74 9.55 14 226147 351 46459550
Ejection fraction decreased 16.65 9.55 39 226122 17898 46442003
Femur fracture 16.53 9.55 108 226053 36889 46423012
Dyspnoea exertional 16.36 9.55 160 226001 50129 46409772
Disturbance in attention 16.29 9.55 88 226073 31472 46428429
Haemoglobin urine present 16.17 9.55 18 226143 648 46459253
General physical health deterioration 16.12 9.55 432 225729 115337 46344564
Hypokalaemia 16.05 9.55 315 225846 87709 46372192
Mean cell haemoglobin concentration increased 16.03 9.55 15 226146 438 46459463
Asthma 15.97 9.55 330 225831 91212 46368689
Dry skin 15.77 9.55 125 226036 40891 46419010
Vitamin K deficiency 15.72 9.55 15 226146 449 46459452
Coma hepatic 15.56 9.55 17 226144 599 46459302
Ventricular arrhythmia 15.54 9.55 44 226117 3377 46456524
Osteonecrosis 15.48 9.55 68 226093 25676 46434225
Multiple sclerosis relapse 15.46 9.55 130 226031 41995 46417906
Hepatic encephalopathy 15.42 9.55 93 226068 10064 46449837
Forced expiratory volume decreased 15.40 9.55 3 226158 5101 46454800
Urine analysis abnormal 15.38 9.55 50 226111 4140 46455761
Vein collapse 15.27 9.55 16 226145 537 46459364
Administration site extravasation 15.25 9.55 17 226144 613 46459288
Breast cancer 15.16 9.55 144 226017 45374 46414527
Synovitis 15.04 9.55 395 225766 60680 46399221
Drug ineffective for unapproved indication 14.99 9.55 36 226125 16377 46443524
Urinary casts 14.90 9.55 15 226146 480 46459421
Inflammation 14.90 9.55 325 225836 48456 46411445
Myelocyte count increased 14.89 9.55 13 226148 346 46459555
Withdrawal syndrome 14.86 9.55 42 226119 18092 46441809
Culture urine positive 14.81 9.55 43 226118 3348 46456553
Beta haemolytic streptococcal infection 14.77 9.55 30 226131 1859 46458042
Transfusion-related acute lung injury 14.62 9.55 8 226153 96 46459805
Post-traumatic stress disorder 14.58 9.55 48 226113 4000 46455901
Spinal stenosis 14.47 9.55 24 226137 12519 46447382
Precancerous cells present 14.35 9.55 23 226138 1184 46458717
Renal papillary necrosis 14.29 9.55 11 226150 244 46459657
Genital haemorrhage 14.21 9.55 7 226154 6559 46453342
Administration site pruritus 14.21 9.55 12 226149 305 46459596
Hypocalcaemia 14.20 9.55 74 226087 26711 46433190
Accidental exposure to product by child 14.18 9.55 22 226139 1101 46458800
Magnesium deficiency 14.17 9.55 14 226147 438 46459463
Lactic acidosis 14.15 9.55 101 226060 33808 46426093
Ageusia 14.14 9.55 21 226140 11451 46448450
Device related thrombosis 14.07 9.55 23 226138 1204 46458697
Cystitis 14.06 9.55 285 225876 41956 46417945
Leukocytosis 13.93 9.55 174 225987 23224 46436677
Peripheral swelling 13.91 9.55 916 225245 157155 46302746
Tinnitus 13.82 9.55 78 226083 27595 46432306
Nail bed inflammation 13.79 9.55 13 226148 383 46459518
Hypoaesthesia 13.70 9.55 455 225706 118414 46341487
Blood creatinine decreased 13.69 9.55 52 226109 4652 46455249
Cognitive disorder 13.69 9.55 253 225908 36630 46423271
Pupillary light reflex tests abnormal 13.64 9.55 9 226152 155 46459746
Drug-induced liver injury 13.58 9.55 185 225976 25183 46434718
Blood count abnormal 13.50 9.55 43 226118 17835 46442066
Musculoskeletal disorder 13.49 9.55 35 226126 15510 46444391
Night sweats 13.49 9.55 196 225965 27054 46432847
Underdose 13.44 9.55 49 226112 19509 46440392
Rash pruritic 13.43 9.55 143 226018 44072 46415829
Autonomic dysreflexia 13.37 9.55 10 226151 212 46459689
Device use error 13.35 9.55 4 226157 5077 46454824
Corneal epithelium defect 13.21 9.55 12 226149 337 46459564
Accidental exposure to product 13.09 9.55 55 226106 21026 46438875
Mood swings 13.05 9.55 38 226123 16214 46443687
Plasma cell myeloma 13.05 9.55 145 226016 44333 46415568
Administration site reaction 13.02 9.55 10 226151 221 46459680
Infusion site haemorrhage 13.00 9.55 31 226130 2143 46457758
Disease recurrence 12.88 9.55 46 226115 18425 46441476
Infusion site discomfort 12.87 9.55 16 226145 649 46459252
Mean cell haemoglobin concentration decreased 12.86 9.55 34 226127 2506 46457395
Orthostatic hypotension 12.86 9.55 179 225982 24479 46435422
Traumatic liver injury 12.85 9.55 11 226150 285 46459616
Gait disturbance 12.80 9.55 574 225587 144689 46315212
Ischaemic stroke 12.78 9.55 40 226121 16682 46443219
Gastrooesophageal reflux disease 12.67 9.55 269 225892 74075 46385826
Arthralgia 12.66 9.55 1981 224180 362622 46097279
Neurotoxicity 12.60 9.55 30 226131 13687 46446214
Syncope 12.60 9.55 399 225762 104404 46355497
Pain 12.54 9.55 2554 223607 474394 45985507
Chills 12.50 9.55 577 225584 95455 46364446
Complication associated with device 12.48 9.55 36 226125 15405 46444496
Suicidal ideation 12.44 9.55 195 225966 56187 46403714
Oral discomfort 12.41 9.55 12 226149 7906 46451995
Transplant rejection 12.39 9.55 17 226144 9579 46450322
Monocyte count increased 12.36 9.55 53 226108 5011 46454890
Blood parathyroid hormone decreased 12.35 9.55 3 226158 4378 46455523
Abdominal distension 12.33 9.55 266 225895 73085 46386816
Pathogen resistance 12.32 9.55 7 226154 6053 46453848
Diabetic ketoacidosis 12.27 9.55 46 226115 18164 46441737
Depression 12.13 9.55 687 225474 169417 46290484
Pyrexia 12.09 9.55 1895 224266 346907 46112994
Adverse drug reaction 12.09 9.55 147 226014 44215 46415686
Hand deformity 12.09 9.55 235 225926 34339 46425562
Pneumocystis jirovecii pneumonia 12.00 9.55 36 226125 15212 46444689
Skin infection 11.98 9.55 95 226066 11244 46448657
Urine oxalate increased 11.95 9.55 9 226152 193 46459708
Basal cell carcinoma 11.79 9.55 55 226106 20432 46439469
Transplant dysfunction 11.74 9.55 4 226157 4678 46455223
Allergy to plants 11.65 9.55 14 226147 548 46459353
Band neutrophil percentage increased 11.64 9.55 9 226152 201 46459700
Sinus tachycardia 11.63 9.55 158 226003 21491 46438410
Infusion site mass 11.61 9.55 18 226143 900 46459001
Congestive hepatopathy 11.54 9.55 32 226129 2426 46457475
Gastric infection 11.53 9.55 35 226126 2793 46457108
Malaise 11.50 9.55 1417 224744 329815 46130086
Administration site bruise 11.49 9.55 10 226151 265 46459636
Vertigo 11.49 9.55 180 225981 51868 46408033
Haematotoxicity 11.47 9.55 10 226151 6923 46452978
Mydriasis 11.47 9.55 89 226072 10464 46449437
Cells in urine 11.40 9.55 8 226153 153 46459748
Dysphoria 11.37 9.55 4 226157 4585 46455316
Haemorrhage 11.37 9.55 192 225969 54677 46405224
Systemic lupus erythematosus 11.35 9.55 235 225926 64945 46394956
Chemical poisoning 11.34 9.55 6 226155 67 46459834
Anaphylactic shock 11.33 9.55 55 226106 20219 46439682
Atypical femur fracture 11.32 9.55 5 226156 4992 46454909
Inappropriate antidiuretic hormone secretion 11.31 9.55 33 226128 14069 46445832
Infective pulmonary exacerbation of cystic fibrosis 11.28 9.55 22 226139 10785 46449116
Hypoxia 11.28 9.55 330 225831 51508 46408393
Posturing 11.25 9.55 13 226148 488 46459413
Head banging 11.24 9.55 12 226149 412 46459489
Febrile bone marrow aplasia 11.23 9.55 10 226151 6852 46453049
Visual acuity reduced 11.22 9.55 62 226099 22051 46437850
Osmolar gap abnormal 11.21 9.55 5 226156 37 46459864
Constipation 11.19 9.55 710 225451 173387 46286514
Wound 11.17 9.55 279 225882 42523 46417378
Bronchitis 11.17 9.55 624 225537 105355 46354546
Coronary artery disease 11.14 9.55 107 226054 33645 46426256
Premature delivery 11.13 9.55 62 226099 22007 46437894
Infusion site irritation 11.08 9.55 13 226148 496 46459405
Diaphragmatic rupture 11.06 9.55 9 226152 217 46459684
Eosinophil percentage increased 11.03 9.55 17 226144 846 46459055
Breast cancer metastatic 10.97 9.55 32 226129 13646 46446255
Balint's syndrome 10.94 9.55 3 226158 3 46459898
Pulmonary arterial hypertension 10.93 9.55 77 226084 25851 46434050
Myelocyte percentage increased 10.93 9.55 8 226153 164 46459737
Herpes zoster 10.91 9.55 417 225744 67455 46392446
Application site pain 10.88 9.55 3 226158 4020 46455881
Immunodeficiency 10.82 9.55 104 226057 13002 46446899
Procedural anxiety 10.73 9.55 13 226148 513 46459388
Nose deformity 10.69 9.55 7 226154 119 46459782
Pharyngitis streptococcal 10.68 9.55 74 226087 8394 46451507
Electrolyte imbalance 10.66 9.55 45 226116 17181 46442720
Flatulence 10.65 9.55 89 226072 28789 46431112
Iron deficiency anaemia 10.62 9.55 45 226116 17161 46442740
Blood alkaline phosphatase increased 10.58 9.55 259 225902 39350 46420551
Temperature regulation disorder 10.50 9.55 38 226123 3322 46456579
Peritoneal perforation 10.49 9.55 7 226154 123 46459778
Incorrect drug administration rate 10.42 9.55 27 226134 1966 46457935
Peripheral sensory neuropathy 10.36 9.55 10 226151 6593 46453308
Parkinsonism 10.34 9.55 14 226147 7934 46451967
Myalgia 10.31 9.55 489 225672 122599 46337302
Gout 10.30 9.55 25 226136 11331 46448570
Cytomegalovirus infection 10.27 9.55 49 226112 18095 46441806
Gait inability 10.23 9.55 115 226046 35088 46424813
Tremor 10.17 9.55 457 225704 115182 46344719
Therapeutic response shortened 10.17 9.55 51 226110 5148 46454753
Infusion site discolouration 10.16 9.55 13 226148 543 46459358
Knee arthroplasty 10.11 9.55 70 226091 23595 46436306
Hepatitis cholestatic 10.05 9.55 61 226100 6616 46453285
Chest pain 10.01 9.55 727 225434 175597 46284304
Flushing 9.92 9.55 395 225766 64219 46395682
Infusion site oedema 9.90 9.55 12 226149 474 46459427
Device breakage 9.89 9.55 20 226141 9672 46450229
Anterior chamber cell 9.81 9.55 13 226148 562 46459339
Body height decreased 9.77 9.55 20 226141 9632 46450269
PCO2 decreased 9.75 9.55 20 226141 1248 46458653
Palpitations 9.75 9.55 370 225791 94889 46365012
Akathisia 9.63 9.55 14 226147 7700 46452201
Peritonitis bacterial 9.58 9.55 17 226144 8636 46451265
Dental restoration failure 9.55 9.55 12 226149 492 46459409
Arteriosclerosis coronary artery 9.55 9.55 70 226091 8086 46451815

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1152.89 9.75 1699 119877 97793 29733109
Toxicity to various agents 1069.53 9.75 2271 119305 174912 29655990
Infusion related reaction 363.59 9.75 617 120959 39947 29790955
Overdose 316.51 9.75 903 120673 83434 29747468
Intentional product misuse 298.39 9.75 518 121058 34149 29796753
Drug abuse 286.10 9.75 856 120720 81216 29749686
Blood pressure fluctuation 240.48 9.75 325 121251 17178 29813724
Acute hepatic failure 196.01 9.75 241 121335 11586 29819316
Intentional overdose 162.07 9.75 451 121125 41030 29789872
Respiratory arrest 146.19 9.75 349 121227 28909 29801993
Drug ineffective 145.90 9.75 800 120776 339587 29491315
Exposure to toxic agent 122.95 9.75 69 121507 1056 29829846
Product dose omission issue 100.35 9.75 135 121441 91496 29739406
Hepatotoxicity 98.90 9.75 224 121352 17921 29812981
Coagulopathy 98.31 9.75 226 121350 18261 29812641
Myocardial infarction 91.63 9.75 237 121339 125388 29705514
Anion gap 91.28 9.75 47 121529 599 29830303
Cardio-respiratory arrest 88.55 9.75 463 121113 56843 29774059
Oxygen saturation decreased 79.24 9.75 368 121208 43072 29787830
Poisoning 78.87 9.75 155 121421 11227 29819675
Blood pressure increased 77.62 9.75 529 121047 71399 29759503
Heart rate decreased 75.86 9.75 222 121354 20772 29810130
Metabolic acidosis 74.81 9.75 326 121250 37135 29793767
Accidental overdose 73.61 9.75 201 121375 18074 29812828
Exposure via ingestion 67.16 9.75 67 121509 2544 29828358
Respiratory depression 66.04 9.75 145 121431 11358 29819544
Hepatic necrosis 64.45 9.75 79 121497 3784 29827118
Substance abuse 62.87 9.75 107 121469 6933 29823969
Alanine aminotransferase increased 61.89 9.75 514 121062 73762 29757140
Diarrhoea 61.70 9.75 970 120606 333133 29497769
Psoriasis 59.44 9.75 51 121525 42455 29788447
Methaemoglobinaemia 58.37 9.75 61 121515 2449 29828453
Sinusitis 56.10 9.75 276 121300 33069 29797833
Cardiac failure 55.83 9.75 164 121412 83254 29747648
Drug resistance 52.89 9.75 9 121567 20124 29810778
Aspartate aminotransferase increased 52.89 9.75 439 121137 62983 29767919
Serotonin syndrome 52.47 9.75 176 121400 17715 29813187
Cardiac arrest 51.51 9.75 590 120986 92260 29738642
Hypotension 50.81 9.75 1117 120459 199448 29631454
Cardiac failure congestive 50.16 9.75 175 121401 84232 29746670
Depressed level of consciousness 47.25 9.75 291 121285 37931 29792971
Treatment failure 46.81 9.75 43 121533 34636 29796266
Liver injury 43.72 9.75 130 121446 12270 29818632
Heart rate irregular 43.67 9.75 129 121447 12130 29818772
Product use in unapproved indication 42.30 9.75 155 121421 73538 29757364
Chills 40.25 9.75 460 121116 71878 29759024
Tachycardia 40.17 9.75 467 121109 73272 29757630
Coronary artery disease 39.17 9.75 90 121486 49622 29781280
Blood pressure diastolic increased 39.06 9.75 52 121524 2706 29828196
Medication error 37.73 9.75 177 121399 20795 29810107
Blood pressure systolic increased 36.91 9.75 140 121436 14970 29815932
Blood pressure diastolic abnormal 36.80 9.75 35 121541 1252 29829650
Foetal exposure during pregnancy 36.71 9.75 58 121518 36813 29794089
Anaemia 36.23 9.75 610 120966 207382 29623520
International normalised ratio increased 34.36 9.75 320 121256 47419 29783483
Analgesic drug level increased 33.75 9.75 24 121552 565 29830337
Contraindicated product administered 33.43 9.75 14 121562 17217 29813685
Heart rate increased 33.32 9.75 270 121306 38451 29792451
Hepatic failure 32.97 9.75 244 121332 33799 29797103
Anion gap abnormal 31.24 9.75 14 121562 128 29830774
Blood pH decreased 30.57 9.75 42 121534 2253 29828649
Infusion site extravasation 30.52 9.75 44 121532 2469 29828433
Blood pressure systolic abnormal 30.44 9.75 34 121542 1473 29829429
Coma 29.54 9.75 272 121304 40177 29790725
Stevens-Johnson syndrome 28.58 9.75 144 121432 17412 29813490
Unresponsive to stimuli 28.28 9.75 194 121382 26225 29804677
Urine sodium decreased 27.22 9.75 14 121562 178 29830724
Drug interaction 27.19 9.75 610 120966 198958 29631944
Blood pressure diastolic decreased 26.56 9.75 70 121506 6161 29824741
Neutrophil percentage increased 26.18 9.75 35 121541 1829 29829073
Acute lung injury 25.91 9.75 27 121549 1080 29829822
Suspected suicide 25.57 9.75 46 121530 3115 29827787
Therapeutic product effect incomplete 25.26 9.75 63 121513 33771 29797131
Brain death 24.95 9.75 40 121536 2466 29828436
Product prescribing error 24.73 9.75 19 121557 16714 29814188
Respiratory rate increased 24.65 9.75 86 121490 8829 29822073
Nasopharyngitis 24.58 9.75 355 121221 58494 29772408
Accidental exposure to product by child 24.53 9.75 31 121545 1532 29829370
Bone marrow failure 23.39 9.75 54 121522 29731 29801171
Prothrombin time prolonged 23.39 9.75 87 121489 9216 29821686
Infusion site pain 23.30 9.75 40 121536 2610 29828292
Body temperature decreased 23.20 9.75 89 121487 9566 29821336
Fatigue 22.97 9.75 1066 120510 319607 29511295
Agitation 22.90 9.75 327 121249 53746 29777156
Body temperature fluctuation 22.88 9.75 27 121549 1242 29829660
Sopor 22.87 9.75 8 121568 10983 29819919
Depression 22.68 9.75 246 121330 90191 29740711
Cerebrovascular accident 22.60 9.75 223 121353 83254 29747648
Infusion site pruritus 22.41 9.75 19 121557 583 29830319
Neuropathy peripheral 22.26 9.75 181 121395 70294 29760608
Hypoxia 22.14 9.75 294 121282 47560 29783342
Dizziness 21.63 9.75 614 120962 194295 29636607
Toxic epidermal necrolysis 21.17 9.75 135 121441 17805 29813097
Suicide attempt 21.13 9.75 235 121341 36462 29794440
Intentional product use issue 20.82 9.75 233 121343 36207 29794695
Pyrexia 20.82 9.75 1424 120152 293065 29537837
Mental status changes 20.70 9.75 236 121340 36843 29794059
Injection site pain 20.69 9.75 59 121517 30251 29800651
General physical health deterioration 20.47 9.75 284 121292 99660 29731242
Transaminases increased 20.41 9.75 164 121412 23293 29807609
Diabetes mellitus 20.30 9.75 94 121482 41771 29789131
Acidosis 20.06 9.75 89 121487 10212 29820690
Progressive multifocal leukoencephalopathy 19.74 9.75 6 121570 9007 29821895
Psoriatic arthropathy 19.59 9.75 21 121555 15740 29815162
Wrong technique in product usage process 19.58 9.75 63 121513 31092 29799810
Asthenia 19.56 9.75 718 120858 220572 29610330
Ear infection 19.41 9.75 70 121506 7304 29823598
Infusion site swelling 19.20 9.75 28 121548 1588 29829314
Oxygen saturation abnormal 19.10 9.75 23 121553 1081 29829821
Lymphocyte percentage decreased 19.02 9.75 32 121544 2054 29828848
Mydriasis 18.51 9.75 61 121515 6082 29824820
Renal papillary necrosis 18.41 9.75 10 121566 143 29830759
Renal injury 18.25 9.75 95 121481 11634 29819268
Electrocardiogram QRS complex prolonged 18.18 9.75 48 121528 4229 29826673
Feeling abnormal 17.81 9.75 146 121430 56610 29774292
Apparent life threatening event 17.56 9.75 11 121565 208 29830694
Flushing 17.50 9.75 190 121386 29302 29801600
Hospitalisation 17.32 9.75 107 121469 44212 29786690
Environmental exposure 16.86 9.75 12 121564 283 29830619
Haemolysis 16.84 9.75 66 121510 7165 29823737
Hepatocellular carcinoma 16.81 9.75 9 121567 9601 29821301
No adverse event 16.78 9.75 28 121548 17391 29813511
Immune reconstitution inflammatory syndrome 16.71 9.75 8 121568 9093 29821809
Body temperature increased 16.69 9.75 110 121466 14670 29816232
Oedema peripheral 16.60 9.75 316 121260 105516 29725386
Balance disorder 16.49 9.75 84 121492 36409 29794493
Administration site pain 16.44 9.75 10 121566 179 29830723
Glycosylated haemoglobin increased 16.44 9.75 9 121567 9482 29821420
Angina pectoris 16.33 9.75 63 121513 29455 29801447
Fluid retention 16.09 9.75 50 121526 24948 29805954
Blood triglycerides increased 15.99 9.75 20 121556 13997 29816905
Granulomatosis with polyangiitis 15.97 9.75 19 121557 882 29830020
Hepatitis C 15.96 9.75 18 121558 13187 29817715
Chronic gastrointestinal bleeding 15.88 9.75 11 121565 248 29830654
Cerebral haemorrhage 15.85 9.75 74 121502 32813 29798089
Graft versus host disease 15.68 9.75 11 121565 10139 29820763
Plasma cell myeloma 15.67 9.75 140 121436 53322 29777580
Osteonecrosis 15.48 9.75 26 121550 16109 29814793
Ureteric obstruction 15.40 9.75 22 121554 1224 29829678
Asthma 15.38 9.75 85 121491 36089 29794813
Venoocclusive liver disease 15.23 9.75 4 121572 6609 29824293
Pemphigus 15.20 9.75 22 121554 1239 29829663
Cytokine release syndrome 15.14 9.75 80 121496 9853 29821049
Prescribed overdose 15.00 9.75 8 121568 8553 29822349
Therapeutic response shortened 14.90 9.75 40 121536 3560 29827342
Anti-erythrocyte antibody positive 14.88 9.75 6 121570 41 29830861
Mycoplasma test positive 14.88 9.75 8 121568 112 29830790
Febrile neutropenia 14.83 9.75 551 121025 106142 29724760
Hangover 14.77 9.75 20 121556 1058 29829844
Peritonitis bacterial 14.32 9.75 15 121561 11363 29819539
Anion gap increased 14.29 9.75 25 121551 1656 29829246
Administration site erythema 14.11 9.75 7 121569 82 29830820
Leukopenia 13.97 9.75 153 121423 56006 29774896
Poor venous access 13.94 9.75 31 121545 2449 29828453
Hypoaesthesia 13.79 9.75 147 121429 54083 29776819
Haematotoxicity 13.71 9.75 4 121572 6166 29824736
Maple syrup disease 13.68 9.75 4 121572 8 29830894
Haematocrit decreased 13.54 9.75 187 121389 30512 29800390
Delirium 13.52 9.75 236 121340 40395 29790507
Drug screen positive 13.49 9.75 44 121532 4363 29826539
Dissociative disorder 13.36 9.75 8 121568 139 29830763
Myopathy 13.27 9.75 14 121562 10572 29820330
Epilepsy 13.23 9.75 40 121536 20129 29810773
Throat tightness 13.15 9.75 61 121515 7131 29823771
Bilirubin urine present 13.02 9.75 7 121569 98 29830804
Endocardial fibrosis 12.95 9.75 5 121571 30 29830872
Acute myocardial infarction 12.86 9.75 145 121431 52794 29778108
Decreased appetite 12.86 9.75 488 121088 149422 29681480
Cardiac disorder 12.80 9.75 102 121474 39791 29791111
Sudden infant death syndrome 12.74 9.75 8 121568 152 29830750
Crystal urine present 12.73 9.75 10 121566 275 29830627
Myalgia 12.61 9.75 227 121349 76440 29754462
Liver transplant 12.48 9.75 32 121544 2770 29828132
Blood ethanol increased 12.43 9.75 11 121565 358 29830544
Memory impairment 12.42 9.75 94 121482 37080 29793822
Off label use 12.27 9.75 859 120717 248431 29582471
Mucosal inflammation 12.24 9.75 73 121503 30421 29800481
Therapeutic response decreased 12.20 9.75 54 121522 24295 29806607
Cytomegalovirus infection 12.17 9.75 52 121524 23622 29807280
Osteonecrosis of jaw 12.15 9.75 37 121539 18581 29812321
Leukocytosis 12.06 9.75 137 121439 21365 29809537
Infusion site bruising 12.05 9.75 9 121567 229 29830673
Pulmonary congestion 11.85 9.75 88 121488 12199 29818703
Analgesic drug level above therapeutic 11.82 9.75 9 121567 236 29830666
Dyspnoea 11.81 9.75 1179 120397 332116 29498786
Ammonia increased 11.80 9.75 41 121535 4200 29826702
Disease progression 11.76 9.75 241 121335 79633 29751269
Dry skin 11.74 9.75 49 121527 22405 29808497
Infusion site nodule 11.62 9.75 6 121570 77 29830825
Visual acuity reduced 11.44 9.75 30 121546 15816 29815086
Polyneuropathy 11.39 9.75 19 121557 11804 29819098
Ultrasound liver abnormal 11.33 9.75 7 121569 129 29830773
Pupillary light reflex tests abnormal 11.29 9.75 7 121569 130 29830772
Bacterial test positive 11.26 9.75 32 121544 2944 29827958
Cerebral infarction 11.20 9.75 62 121514 26311 29804591
Vessel puncture site bruise 11.13 9.75 5 121571 46 29830856
Ascites 11.00 9.75 93 121483 35828 29795074
Renal impairment 10.96 9.75 259 121317 83925 29746977
Brain oedema 10.96 9.75 87 121489 12311 29818591
Infusion site erythema 10.90 9.75 22 121554 1624 29829278
Post transplant lymphoproliferative disorder 10.80 9.75 4 121572 5302 29825600
Stomatitis 10.76 9.75 98 121478 37181 29793721
Sputum culture positive 10.73 9.75 24 121552 1903 29828999
Urticaria 10.72 9.75 294 121282 54312 29776590
Hallucinations, mixed 10.69 9.75 28 121548 2455 29828447
Urobilinogen urine increased 10.62 9.75 10 121566 353 29830549
Product quality issue 10.43 9.75 40 121536 18734 29812168
Muscle spasms 10.34 9.75 193 121383 64645 29766257
Hyperchloraemia 10.34 9.75 11 121565 451 29830451
Injection site haemorrhage 10.29 9.75 10 121566 7845 29823057
Antineutrophil cytoplasmic antibody positive 10.20 9.75 11 121565 458 29830444
Vital functions abnormal 10.19 9.75 6 121570 101 29830801
Alopecia 10.12 9.75 42 121534 19233 29811669
Prostatic specific antigen increased 10.05 9.75 21 121555 11983 29818919
Bacterial test 10.02 9.75 7 121569 160 29830742
Drug ineffective for unapproved indication 10.01 9.75 18 121558 10862 29820040
Malaise 9.99 9.75 565 121011 166397 29664505
Therapeutic product effect decreased 9.96 9.75 73 121503 29003 29801899
Rheumatoid arthritis 9.92 9.75 228 121348 40969 29789933
Bilevel positive airway pressure 9.89 9.75 6 121570 107 29830795
Nausea 9.89 9.75 1055 120521 295902 29535000
Febrile bone marrow aplasia 9.83 9.75 11 121565 8086 29822816
Product substitution issue 9.78 9.75 16 121560 10019 29820883

Pharmacologic Action:

SourceCodeDescription
ATC N07XX59 NERVOUS SYSTEM
OTHER NERVOUS SYSTEM DRUGS
OTHER NERVOUS SYSTEM DRUGS
Other nervous system drugs
ATC R05DA09 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Opium alkaloids and derivatives
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50266 prodrugs
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:51177 cough suppressant
CHEBI has role CHEBI:60643 n-methyl-d-aspartate receptor antagonists
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:146270 oneirogens
MeSH PA D000996 Antitussive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D019141 Respiratory System Agents
FDA MoA N0000181819 Uncompetitive NMDA Receptor Antagonists
FDA EPC N0000181821 Uncompetitive N-methyl-D-aspartate Receptor Antagonist
FDA MoA N0000182147 Sigma-1 Receptor Agonists
FDA EPC N0000182149 Sigma-1 Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Sore throat symptom indication 267102003
Influenza-like symptoms indication 315642008
Fever indication 386661006
Pseudobulbar affect indication 432776007
Mouth Irritation indication
Opioid withdrawal off-label use 87132004
Neurotoxicity caused by methotrexate off-label use 129666005
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Hyperbilirubinemia contraindication 14783006 DOID:2741
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Lowered convulsive threshold contraindication 19260006
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Disorder of the central nervous system contraindication 23853001 DOID:331
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Torsades de pointes contraindication 31722008
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Methemoglobinemia contraindication 38959009 DOID:10783
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Left ventricular hypertrophy contraindication 55827005
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Poisoning by acetaminophen contraindication 70273001
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Disorder of brain contraindication 81308009 DOID:936
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Left heart failure contraindication 85232009
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Acute abdominal pain contraindication 116290004
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Hypomagnesemia contraindication 190855004
Drug-induced psychosis contraindication 191483003 DOID:1742
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Traumatic injury contraindication 417746004
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor AGONIST D2 6.46 WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A Ion channel ANTAGONIST IC50 5.70 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 8.84 DRUG MATRIX
Cytochrome P450 2D6 Enzyme Ks 4.48 WOMBAT-PK
Glutamate receptor ionotropic, NMDA 2C Ion channel BLOCKER IC50 6.33 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.89 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane other IC50 7.82 CHEMBL
Glutamate NMDA receptor Ion channel Ki 5.65 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 5.29 CHEMBL

External reference:

IDSource
4020116 VUID
N0000179729 NUI
D00848 KEGG_DRUG
7487-74-3 SECONDARY_CAS_RN
4018051 VANDF
4018052 VANDF
4020116 VANDF
C0011816 UMLSCUI
CHEBI:4470 CHEBI
5360696 PUBCHEM_CID
CHEMBL52440 ChEMBL_ID
CHEMBL1256818 ChEMBL_ID
CHEMBL1201004 ChEMBL_ID
CHEMBL1201461 ChEMBL_ID
DB00514 DRUGBANK_ID
D003915 MESH_DESCRIPTOR_UI
6953 IUPHAR_LIGAND_ID
166 INN_ID
7355X3ROTS UNII
102490 RXNORM
18766 MMSL
44093 MMSL
4565 MMSL
4566 MMSL
73044 MMSL
d00207 MMSL
001653 NDDF
004427 NDDF
005215 NDDF
2016004 SNOMEDCT_US
387114001 SNOMEDCT_US
387237004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Robitussin Elderberry Maximum Strength Cough plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2097 SOLUTION 20 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Elderberry Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-2098 SOLUTION 20 mg ORAL OTC monograph final 15 sections
CHILDRENS DIMETAPP COLD AND COUGH HUMAN OTC DRUG LABEL 3 0031-2234 LIQUID 5 mg ORAL OTC monograph final 16 sections
Childrens Dimetapp Multi-Symptom Cold Relief Dye-Free HUMAN OTC DRUG LABEL 3 0031-2295 SOLUTION 10 mg ORAL OTC monograph final 17 sections
Robitussin Tos Seca HUMAN OTC DRUG LABEL 1 0031-8652 SYRUP 10 mg ORAL Export only 1 sections
Robitussin 12 Hour Cough Relief HUMAN OTC DRUG LABEL 1 0031-8655 SUSPENSION, EXTENDED RELEASE 30 mg ORAL ANDA 15 sections
Robitussin CF HUMAN OTC DRUG LABEL 3 0031-8678 LIQUID 10 mg ORAL Export only 15 sections
Childrens Robitussin Nighttime Cough Long-Acting DM HUMAN OTC DRUG LABEL 2 0031-8692 SOLUTION 15 mg ORAL OTC monograph final 17 sections
CHILDRENS ROBITUSSIN COUGH AND COLD LONG-ACTING HUMAN OTC DRUG LABEL 2 0031-8693 LIQUID 7.50 mg ORAL OTC monograph final 17 sections
Childrens Robitussin Cough Long-Acting HUMAN OTC DRUG LABEL 1 0031-8694 LIQUID 7.50 mg ORAL OTC monograph final 14 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8702 LIQUID 20 mg ORAL OTC MONOGRAPH FINULLL 15 sections
Childrens Robitussin Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8715 LIQUID 5 mg ORAL OTC monograph final 15 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 5 mg ORAL OTC monograph final 16 sections
Robitussin Maximum Strength Nighttime Cough DM HUMAN OTC DRUG LABEL 2 0031-8718 SOLUTION 30 mg ORAL OTC monograph final 17 sections
Robitussin Maximum Strength Cough Plus Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8719 CAPSULE, LIQUID FILLED 10 mg ORAL OTC MONOGRAPH FINULLL 15 sections
ROBITUSSIN PEAK COLD DAYTIME COLD PLUS FLU HUMAN OTC DRUG LABEL 3 0031-8721 CAPSULE, LIQUID FILLED 10 mg ORAL OTC MONOGRAPH FINULLL 17 sections
Childrens Robitussin 12 Hour Cough Relief HUMAN OTC DRUG LABEL 1 0031-8725 SUSPENSION, EXTENDED RELEASE 30 mg ORAL ANDA 15 sections
Childrens Robitussin 12 Hour Cough Relief HUMAN OTC DRUG LABEL 1 0031-8726 SUSPENSION, EXTENDED RELEASE 30 mg ORAL ANDA 15 sections
ROBITUSSIN MAXIMUM STRENGTH COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8739 SOLUTION 20 mg ORAL OTC monograph final 15 sections
ROBITUSSIN LINGERING COLD LONG-ACTING COUGHGELS HUMAN OTC DRUG LABEL 1 0031-8741 CAPSULE, LIQUID FILLED 15 mg ORAL OTC monograph final 14 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 10 mg ORAL OTC MONOGRAPH FINULLL 17 sections
ROBITUSSIN LONG-ACTING COUGHGELS HUMAN OTC DRUG LABEL 1 0031-8743 CAPSULE, LIQUID FILLED 15 mg ORAL OTC MONOGRAPH FINULLL 15 sections
Robitussin Maximum Strength Severe Multi-Symptom 7 in 1 Relief Nighttime HUMAN OTC DRUG LABEL 3 0031-8744 CAPSULE, LIQUID FILLED 15 mg ORAL OTC MONOGRAPH FINULLL 17 sections
Robitussin Maximum Strength Severe Cough Plus Sore Throat HUMAN OTC DRUG LABEL 2 0031-8750 LIQUID 20 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 20 mg ORAL OTC monograph final 17 sections
Robitussin 12 Hour Cough Relief HUMAN OTC DRUG LABEL 1 0031-8753 SUSPENSION, EXTENDED RELEASE 30 mg ORAL ANDA 15 sections
Robitussin 12 Hour Cough Relief HUMAN OTC DRUG LABEL 1 0031-8754 SUSPENSION, EXTENDED RELEASE 30 mg ORAL ANDA 15 sections
Robitussin 12 Hour Cough Relief HUMAN OTC DRUG LABEL 1 0031-8755 SUSPENSION, EXTENDED RELEASE 30 mg ORAL ANDA 15 sections
Robitussin Honey Maximum Strength Cough and Chest Congestion DM HUMAN OTC DRUG LABEL 2 0031-8756 SOLUTION 20 mg ORAL OTC monograph final 15 sections
ROBITUSSIN COUGH PLUS CHEST CONGESTION DM HUMAN OTC DRUG LABEL 2 0031-8757 SOLUTION 20 mg ORAL OTC monograph final 15 sections