Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor antagonists/agonists, morphinan derivates | 1845 | 57-27-2 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
30 | mg | P |
30 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 57.14 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.85 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 24 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.65 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 6928.12 | 9.44 | 6036 | 150766 | 237789 | 46291471 |
Drug abuse | 1000.05 | 9.44 | 1147 | 155655 | 62261 | 46466999 |
Toxicity to various agents | 630.02 | 9.44 | 1846 | 154956 | 209920 | 46319340 |
Respiratory depression | 353.59 | 9.44 | 301 | 156501 | 11299 | 46517961 |
Overdose | 336.58 | 9.44 | 924 | 155878 | 101055 | 46428205 |
Accidental overdose | 327.77 | 9.44 | 370 | 156432 | 19696 | 46509564 |
Respiratory arrest | 324.39 | 9.44 | 479 | 156323 | 33337 | 46495923 |
Death | 306.83 | 9.44 | 2051 | 154751 | 333497 | 46195763 |
Miosis | 245.46 | 9.44 | 193 | 156609 | 6464 | 46522796 |
Drug dependence | 238.82 | 9.44 | 314 | 156488 | 19587 | 46509673 |
Somnolence | 198.83 | 9.44 | 1044 | 155758 | 155477 | 46373783 |
Sedation | 189.41 | 9.44 | 303 | 156499 | 22607 | 46506653 |
Depressed level of consciousness | 178.10 | 9.44 | 452 | 156350 | 47117 | 46482143 |
Cardiac arrest | 161.98 | 9.44 | 667 | 156135 | 89732 | 46439528 |
Completed suicide | 157.75 | 9.44 | 932 | 155870 | 144988 | 46384272 |
Contrast media allergy | 153.78 | 9.44 | 88 | 156714 | 1711 | 46527549 |
Alopecia | 152.36 | 9.44 | 193 | 156609 | 162221 | 46367039 |
Coma | 150.73 | 9.44 | 485 | 156317 | 57864 | 46471396 |
Drug withdrawal syndrome | 150.36 | 9.44 | 303 | 156499 | 27081 | 46502179 |
Cardio-respiratory arrest | 146.90 | 9.44 | 489 | 156313 | 59380 | 46469880 |
Bradypnoea | 145.34 | 9.44 | 103 | 156699 | 2936 | 46526324 |
Unresponsive to stimuli | 142.18 | 9.44 | 326 | 156476 | 31848 | 46497412 |
Constipation | 139.65 | 9.44 | 1032 | 155770 | 173065 | 46356195 |
Vomiting | 138.34 | 9.44 | 2210 | 154592 | 450584 | 46078676 |
Pemphigus | 126.73 | 9.44 | 6 | 156796 | 45268 | 46483992 |
Substance abuse | 124.67 | 9.44 | 107 | 156695 | 4060 | 46525200 |
Inadequate analgesia | 119.77 | 9.44 | 89 | 156713 | 2735 | 46526525 |
Respiratory rate decreased | 116.45 | 9.44 | 91 | 156711 | 3019 | 46526241 |
Sedation complication | 116.04 | 9.44 | 97 | 156705 | 3548 | 46525712 |
Hyperaesthesia | 111.81 | 9.44 | 135 | 156667 | 7721 | 46521539 |
Product dose omission issue | 111.22 | 9.44 | 251 | 156551 | 168269 | 46360991 |
Systemic lupus erythematosus | 111.03 | 9.44 | 40 | 156762 | 65140 | 46464120 |
Myoclonus | 106.74 | 9.44 | 181 | 156621 | 14171 | 46515089 |
Malignant neoplasm progression | 105.38 | 9.44 | 465 | 156337 | 64461 | 46464799 |
Delirium | 103.99 | 9.44 | 318 | 156484 | 36910 | 46492350 |
Intestinal pseudo-obstruction | 98.30 | 9.44 | 47 | 156755 | 620 | 46528640 |
Confusional state | 95.01 | 9.44 | 886 | 155916 | 159006 | 46370254 |
Hypotension | 91.74 | 9.44 | 1188 | 155614 | 231401 | 46297859 |
Glossodynia | 90.95 | 9.44 | 19 | 156783 | 44354 | 46484906 |
Acute chest syndrome | 89.63 | 9.44 | 42 | 156760 | 528 | 46528732 |
Mental status changes | 88.90 | 9.44 | 306 | 156496 | 37782 | 46491478 |
Exposure via ingestion | 87.77 | 9.44 | 81 | 156721 | 3386 | 46525874 |
Headache | 86.22 | 9.44 | 1112 | 155690 | 477240 | 46052020 |
Drug abuser | 84.70 | 9.44 | 77 | 156725 | 3156 | 46526104 |
Creatinine renal clearance decreased | 82.71 | 9.44 | 109 | 156693 | 6811 | 46522449 |
Fatigue | 79.96 | 9.44 | 1503 | 155299 | 607194 | 45922066 |
Drug screen positive | 79.85 | 9.44 | 81 | 156721 | 3810 | 46525450 |
Injection site pain | 79.63 | 9.44 | 149 | 156653 | 107003 | 46422257 |
Poisoning | 79.39 | 9.44 | 157 | 156645 | 13837 | 46515423 |
Device expulsion | 79.24 | 9.44 | 3 | 156799 | 27539 | 46501721 |
Soft tissue disorder | 78.45 | 9.44 | 83 | 156719 | 4103 | 46525157 |
Drug diversion | 75.97 | 9.44 | 43 | 156759 | 818 | 46528442 |
Maternal exposure during delivery | 75.38 | 9.44 | 42 | 156760 | 774 | 46528486 |
Abdominal discomfort | 74.58 | 9.44 | 259 | 156543 | 150906 | 46378354 |
Hallucination | 73.78 | 9.44 | 348 | 156454 | 49603 | 46479657 |
Off label use | 73.63 | 9.44 | 869 | 155933 | 378972 | 46150288 |
Injection site erythema | 73.37 | 9.44 | 85 | 156717 | 74342 | 46454918 |
Arthropathy | 68.17 | 9.44 | 112 | 156690 | 84588 | 46444672 |
Drug ineffective | 65.28 | 9.44 | 1757 | 155045 | 676081 | 45853179 |
Dizziness | 64.71 | 9.44 | 782 | 156020 | 339632 | 46189628 |
White blood cell count abnormal | 64.71 | 9.44 | 83 | 156719 | 5049 | 46524211 |
Arthralgia | 63.95 | 9.44 | 852 | 155950 | 363751 | 46165509 |
Apnoea | 63.31 | 9.44 | 99 | 156703 | 7240 | 46522020 |
Abortion spontaneous | 62.95 | 9.44 | 34 | 156768 | 43612 | 46485648 |
Rheumatoid arthritis | 61.79 | 9.44 | 513 | 156289 | 239702 | 46289558 |
Drug tolerance | 57.12 | 9.44 | 62 | 156740 | 3156 | 46526104 |
Intentional product misuse | 56.73 | 9.44 | 310 | 156492 | 46818 | 46482442 |
Rheumatoid factor positive | 56.34 | 9.44 | 3 | 156799 | 20458 | 46508802 |
Nasopharyngitis | 56.18 | 9.44 | 296 | 156506 | 153702 | 46375558 |
Respiratory failure | 56.05 | 9.44 | 525 | 156277 | 94291 | 46434969 |
Injection site reaction | 54.75 | 9.44 | 48 | 156754 | 47801 | 46481459 |
Dilatation intrahepatic duct acquired | 54.18 | 9.44 | 33 | 156769 | 723 | 46528537 |
Diarrhoea | 52.86 | 9.44 | 1454 | 155348 | 558148 | 45971112 |
Hypercapnia | 50.92 | 9.44 | 70 | 156732 | 4556 | 46524704 |
Withdrawal syndrome | 50.72 | 9.44 | 155 | 156647 | 17979 | 46511281 |
Asphyxia | 50.40 | 9.44 | 75 | 156727 | 5251 | 46524009 |
Blood calcium decreased | 48.63 | 9.44 | 139 | 156663 | 15534 | 46513726 |
Cough | 48.36 | 9.44 | 517 | 156285 | 229732 | 46299528 |
Sinusitis | 48.12 | 9.44 | 248 | 156554 | 129520 | 46399740 |
Obliterative bronchiolitis | 47.93 | 9.44 | 43 | 156759 | 1732 | 46527528 |
Injection site pruritus | 47.77 | 9.44 | 38 | 156764 | 39705 | 46489555 |
Poisoning deliberate | 47.49 | 9.44 | 91 | 156711 | 7835 | 46521425 |
Pain | 46.10 | 9.44 | 1999 | 154803 | 474949 | 46054311 |
Cardiac failure congestive | 46.03 | 9.44 | 156 | 156646 | 91594 | 46437666 |
Anterior spinal artery syndrome | 44.69 | 9.44 | 14 | 156788 | 50 | 46529210 |
Hypoxia | 44.17 | 9.44 | 312 | 156490 | 51526 | 46477734 |
Injection site swelling | 43.14 | 9.44 | 43 | 156759 | 40284 | 46488976 |
Respiratory acidosis | 42.40 | 9.44 | 75 | 156727 | 6073 | 46523187 |
Hand deformity | 41.63 | 9.44 | 33 | 156769 | 34541 | 46494719 |
Weight increased | 40.12 | 9.44 | 356 | 156446 | 164117 | 46365143 |
Drug withdrawal syndrome neonatal | 39.31 | 9.44 | 40 | 156762 | 1888 | 46527372 |
Pulseless electrical activity | 38.97 | 9.44 | 79 | 156723 | 7088 | 46522172 |
Asthma | 38.59 | 9.44 | 167 | 156635 | 91375 | 46437885 |
Acidosis | 38.53 | 9.44 | 103 | 156699 | 11071 | 46518189 |
Urinary retention | 38.06 | 9.44 | 181 | 156621 | 25880 | 46503380 |
Cancer pain | 38.00 | 9.44 | 44 | 156758 | 2406 | 46526854 |
Lethargy | 37.93 | 9.44 | 298 | 156504 | 50873 | 46478387 |
Accidental death | 37.29 | 9.44 | 38 | 156764 | 1797 | 46527463 |
Maternal exposure during pregnancy | 36.88 | 9.44 | 198 | 156604 | 102351 | 46426909 |
Accidental exposure to product by child | 35.98 | 9.44 | 30 | 156772 | 1093 | 46528167 |
Systemic mastocytosis | 35.21 | 9.44 | 15 | 156787 | 148 | 46529112 |
Visceral congestion | 34.96 | 9.44 | 18 | 156784 | 281 | 46528979 |
Agitation | 34.84 | 9.44 | 311 | 156491 | 55104 | 46474156 |
Narcotic bowel syndrome | 34.78 | 9.44 | 14 | 156788 | 118 | 46529142 |
Nasal congestion | 34.76 | 9.44 | 68 | 156734 | 48045 | 46481215 |
Sphincter of Oddi dysfunction | 34.55 | 9.44 | 19 | 156783 | 341 | 46528919 |
Myalgia | 34.32 | 9.44 | 257 | 156545 | 122831 | 46406429 |
Foetal megacystis | 34.27 | 9.44 | 10 | 156792 | 26 | 46529234 |
Iodine allergy | 34.13 | 9.44 | 22 | 156780 | 534 | 46528726 |
Erythema | 34.01 | 9.44 | 311 | 156491 | 142509 | 46386751 |
Anaphylactic reaction | 32.84 | 9.44 | 297 | 156505 | 52815 | 46476445 |
Pneumonia viral | 32.49 | 9.44 | 70 | 156732 | 6554 | 46522706 |
Pain in extremity | 32.14 | 9.44 | 644 | 156158 | 258036 | 46271224 |
Abdominal pain | 32.07 | 9.44 | 1005 | 155797 | 229026 | 46300234 |
Oxygen saturation decreased | 31.84 | 9.44 | 364 | 156438 | 68800 | 46460460 |
Allodynia | 31.72 | 9.44 | 21 | 156781 | 534 | 46528726 |
Pancreatic fibrosis | 31.48 | 9.44 | 12 | 156790 | 86 | 46529174 |
Pericarditis | 31.19 | 9.44 | 21 | 156781 | 23906 | 46505354 |
Sopor | 30.77 | 9.44 | 14 | 156788 | 19814 | 46509446 |
Gangrene | 30.74 | 9.44 | 56 | 156746 | 4639 | 46524621 |
Pulmonary oedema | 30.69 | 9.44 | 284 | 156518 | 50821 | 46478439 |
Coronary artery disease | 30.68 | 9.44 | 41 | 156761 | 33711 | 46495549 |
Wrong technique in product usage process | 30.49 | 9.44 | 88 | 156714 | 54334 | 46474926 |
Pregnancy | 30.11 | 9.44 | 28 | 156774 | 27109 | 46502151 |
Aspiration | 30.03 | 9.44 | 85 | 156717 | 9446 | 46519814 |
No adverse event | 29.70 | 9.44 | 43 | 156759 | 34188 | 46495072 |
Post procedural complication | 29.67 | 9.44 | 118 | 156684 | 15611 | 46513649 |
Condition aggravated | 28.40 | 9.44 | 617 | 156185 | 244435 | 46284825 |
Colitis microscopic | 27.39 | 9.44 | 65 | 156737 | 6491 | 46522769 |
Cyanosis | 26.35 | 9.44 | 115 | 156687 | 15856 | 46513404 |
Myocardial infarction | 26.07 | 9.44 | 206 | 156596 | 97322 | 46431938 |
Infective pulmonary exacerbation of cystic fibrosis | 25.82 | 9.44 | 3 | 156799 | 10804 | 46518456 |
Implant site extravasation | 25.74 | 9.44 | 18 | 156784 | 502 | 46528758 |
Osteoarthritis | 25.62 | 9.44 | 114 | 156688 | 61911 | 46467349 |
Nausea | 25.55 | 9.44 | 2658 | 154144 | 684796 | 45844464 |
Transient ischaemic attack | 25.50 | 9.44 | 49 | 156753 | 34854 | 46494406 |
Cerebrovascular accident | 25.37 | 9.44 | 217 | 156585 | 100822 | 46428438 |
Cholestasis | 25.37 | 9.44 | 166 | 156636 | 26727 | 46502533 |
Ear infection | 25.23 | 9.44 | 24 | 156778 | 22989 | 46506271 |
Hepatic enzyme increased | 25.12 | 9.44 | 166 | 156636 | 81621 | 46447639 |
Injection site rash | 24.80 | 9.44 | 11 | 156791 | 15802 | 46513458 |
Disease progression | 24.50 | 9.44 | 437 | 156365 | 90863 | 46438397 |
Dyspnoea exertional | 24.21 | 9.44 | 87 | 156715 | 50202 | 46479058 |
Helicobacter infection | 24.10 | 9.44 | 5 | 156797 | 11731 | 46517529 |
Breakthrough pain | 23.67 | 9.44 | 24 | 156778 | 1128 | 46528132 |
Pruritus allergic | 23.64 | 9.44 | 23 | 156779 | 1028 | 46528232 |
Pupil fixed | 23.57 | 9.44 | 29 | 156773 | 1691 | 46527569 |
Tonsillar disorder | 23.55 | 9.44 | 22 | 156780 | 934 | 46528326 |
Hypoxic-ischaemic encephalopathy | 23.47 | 9.44 | 46 | 156756 | 4027 | 46525233 |
Spinal epidural haemorrhage | 23.35 | 9.44 | 10 | 156792 | 100 | 46529160 |
Vascular resistance systemic decreased | 23.09 | 9.44 | 10 | 156792 | 103 | 46529157 |
Drug resistance | 22.97 | 9.44 | 15 | 156787 | 17353 | 46511907 |
Syncope | 22.50 | 9.44 | 234 | 156568 | 104569 | 46424691 |
Toxic leukoencephalopathy | 22.50 | 9.44 | 17 | 156785 | 536 | 46528724 |
Metastases to bone | 22.41 | 9.44 | 117 | 156685 | 17359 | 46511901 |
Complex regional pain syndrome | 22.34 | 9.44 | 31 | 156771 | 2035 | 46527225 |
Mucosal inflammation | 22.11 | 9.44 | 214 | 156588 | 38762 | 46490498 |
Femur fracture | 22.08 | 9.44 | 58 | 156744 | 36939 | 46492321 |
Breast cancer | 21.74 | 9.44 | 79 | 156723 | 45439 | 46483821 |
Basal cell carcinoma | 21.73 | 9.44 | 22 | 156780 | 20465 | 46508795 |
Spinal cord compression | 21.71 | 9.44 | 42 | 156760 | 3642 | 46525618 |
Implant site discharge | 21.68 | 9.44 | 10 | 156792 | 121 | 46529139 |
Sepsis | 21.30 | 9.44 | 603 | 156199 | 135411 | 46393849 |
Medication error | 21.27 | 9.44 | 177 | 156625 | 30734 | 46498526 |
Gallbladder cholesterolosis | 21.25 | 9.44 | 19 | 156783 | 762 | 46528498 |
Antinuclear antibody negative | 21.21 | 9.44 | 12 | 156790 | 228 | 46529032 |
Catheter site granuloma | 21.16 | 9.44 | 5 | 156797 | 3 | 46529257 |
Progressive multifocal leukoencephalopathy | 21.02 | 9.44 | 6 | 156796 | 11340 | 46517920 |
Peripheral nerve injury | 20.91 | 9.44 | 14 | 156788 | 363 | 46528897 |
Urinary bladder rupture | 20.84 | 9.44 | 10 | 156792 | 133 | 46529127 |
Hypoventilation | 20.81 | 9.44 | 44 | 156758 | 4066 | 46525194 |
Anaesthetic complication | 20.76 | 9.44 | 28 | 156774 | 1789 | 46527471 |
Cardiac output decreased | 20.59 | 9.44 | 20 | 156782 | 892 | 46528368 |
Product quality issue | 20.44 | 9.44 | 57 | 156745 | 35591 | 46493669 |
Injection site bruising | 20.42 | 9.44 | 57 | 156745 | 35579 | 46493681 |
Incoherent | 20.23 | 9.44 | 46 | 156756 | 4466 | 46524794 |
Influenza like illness | 20.22 | 9.44 | 112 | 156690 | 57458 | 46471802 |
Cognitive disorder | 20.18 | 9.44 | 201 | 156601 | 36682 | 46492578 |
Musculoskeletal stiffness | 20.14 | 9.44 | 221 | 156581 | 97772 | 46431488 |
Patient uncooperative | 19.95 | 9.44 | 10 | 156792 | 147 | 46529113 |
Contusion | 19.75 | 9.44 | 193 | 156609 | 87294 | 46441966 |
Red blood cell sedimentation rate increased | 19.61 | 9.44 | 29 | 156773 | 22860 | 46506400 |
Serotonin syndrome | 19.60 | 9.44 | 144 | 156658 | 24076 | 46505184 |
Small intestinal obstruction | 19.20 | 9.44 | 106 | 156696 | 16066 | 46513194 |
Palpitations | 19.12 | 9.44 | 216 | 156586 | 95043 | 46434217 |
Orthostatic hypotension | 19.04 | 9.44 | 145 | 156657 | 24513 | 46504747 |
White blood cell count decreased | 18.96 | 9.44 | 264 | 156538 | 111967 | 46417293 |
Pulmonary congestion | 18.93 | 9.44 | 99 | 156703 | 14700 | 46514560 |
Interstitial lung disease | 18.92 | 9.44 | 105 | 156697 | 53844 | 46475416 |
Suicide attempt | 18.83 | 9.44 | 108 | 156694 | 54928 | 46474332 |
Hospitalisation | 18.79 | 9.44 | 130 | 156672 | 63255 | 46466005 |
Contraindicated product administered | 18.62 | 9.44 | 175 | 156627 | 79772 | 46449488 |
Respiratory rate increased | 18.62 | 9.44 | 82 | 156720 | 11351 | 46517909 |
Metastases to eye | 18.54 | 9.44 | 9 | 156793 | 123 | 46529137 |
Treatment failure | 18.32 | 9.44 | 212 | 156590 | 92875 | 46436385 |
Sickle cell anaemia with crisis | 18.24 | 9.44 | 41 | 156761 | 3951 | 46525309 |
Infusion related reaction | 18.21 | 9.44 | 235 | 156567 | 100973 | 46428287 |
Foetal heart rate abnormal | 18.19 | 9.44 | 15 | 156787 | 538 | 46528722 |
Loss of personal independence in daily activities | 18.10 | 9.44 | 115 | 156687 | 57068 | 46472192 |
Therapy cessation | 18.08 | 9.44 | 39 | 156763 | 26590 | 46502670 |
Gastrooesophageal reflux disease | 18.07 | 9.44 | 161 | 156641 | 74183 | 46455077 |
Injection site warmth | 18.07 | 9.44 | 12 | 156790 | 13760 | 46515500 |
Bronchitis | 18.01 | 9.44 | 249 | 156553 | 105730 | 46423530 |
Tendonitis | 17.99 | 9.44 | 13 | 156789 | 14264 | 46514996 |
Seronegative arthritis | 17.90 | 9.44 | 17 | 156785 | 737 | 46528523 |
Hepatic function abnormal | 17.61 | 9.44 | 58 | 156744 | 34363 | 46494897 |
Intentional self-injury | 17.59 | 9.44 | 34 | 156768 | 24132 | 46505128 |
Respiratory distress | 17.50 | 9.44 | 174 | 156628 | 31742 | 46497518 |
Atrial fibrillation | 17.38 | 9.44 | 244 | 156558 | 103346 | 46425914 |
Retrograde amnesia | 17.27 | 9.44 | 12 | 156790 | 331 | 46528929 |
Increased bronchial secretion | 17.13 | 9.44 | 24 | 156778 | 1590 | 46527670 |
Brain oedema | 17.02 | 9.44 | 85 | 156717 | 12393 | 46516867 |
Central nervous system injury | 17.01 | 9.44 | 9 | 156793 | 149 | 46529111 |
Chronic kidney disease | 16.95 | 9.44 | 75 | 156727 | 40796 | 46488464 |
Substance use | 16.88 | 9.44 | 13 | 156789 | 422 | 46528838 |
Administration site abscess | 16.87 | 9.44 | 5 | 156797 | 14 | 46529246 |
Disorientation | 16.85 | 9.44 | 194 | 156608 | 36724 | 46492536 |
Blood pH decreased | 16.78 | 9.44 | 31 | 156771 | 2596 | 46526664 |
Herpes simplex reactivation | 16.75 | 9.44 | 12 | 156790 | 348 | 46528912 |
Throat irritation | 16.73 | 9.44 | 46 | 156756 | 28855 | 46500405 |
Neuroendocrine tumour of the lung | 16.62 | 9.44 | 5 | 156797 | 15 | 46529245 |
Fluid retention | 16.49 | 9.44 | 102 | 156700 | 50944 | 46478316 |
Rash | 16.48 | 9.44 | 1005 | 155797 | 355507 | 46173753 |
Multiple sclerosis relapse | 16.46 | 9.44 | 79 | 156723 | 42046 | 46487214 |
Peptic ulcer perforation | 16.39 | 9.44 | 9 | 156793 | 161 | 46529099 |
Hallucination, tactile | 16.34 | 9.44 | 10 | 156792 | 221 | 46529039 |
Abortion induced | 16.31 | 9.44 | 7 | 156795 | 10253 | 46519007 |
Arterial occlusive disease | 16.28 | 9.44 | 44 | 156758 | 4760 | 46524500 |
Influenza | 16.16 | 9.44 | 207 | 156595 | 89063 | 46440197 |
Administration site induration | 16.15 | 9.44 | 5 | 156797 | 17 | 46529243 |
Faecaloma | 16.13 | 9.44 | 60 | 156742 | 7692 | 46521568 |
Flushing | 16.11 | 9.44 | 139 | 156663 | 64475 | 46464785 |
Congenital pulmonary hypertension | 16.09 | 9.44 | 7 | 156795 | 73 | 46529187 |
Coombs positive haemolytic anaemia | 15.89 | 9.44 | 12 | 156790 | 378 | 46528882 |
Gastrointestinal disorder | 15.84 | 9.44 | 126 | 156676 | 59450 | 46469810 |
Abnormal behaviour | 15.80 | 9.44 | 123 | 156679 | 20935 | 46508325 |
Cardiac failure | 15.76 | 9.44 | 182 | 156620 | 79766 | 46449494 |
Wound | 15.73 | 9.44 | 82 | 156720 | 42720 | 46486540 |
Blood pressure diastolic increased | 15.72 | 9.44 | 50 | 156752 | 5924 | 46523336 |
Administration site discharge | 15.72 | 9.44 | 5 | 156797 | 19 | 46529241 |
Tumour pain | 15.69 | 9.44 | 20 | 156782 | 1209 | 46528051 |
Bradycardia | 15.60 | 9.44 | 311 | 156491 | 65987 | 46463273 |
Weaning failure | 15.51 | 9.44 | 11 | 156791 | 314 | 46528946 |
Myocardial fibrosis | 15.48 | 9.44 | 14 | 156788 | 570 | 46528690 |
Withdrawal catatonia | 15.40 | 9.44 | 6 | 156796 | 46 | 46529214 |
Vertigo | 15.30 | 9.44 | 107 | 156695 | 51941 | 46477319 |
Ill-defined disorder | 15.30 | 9.44 | 43 | 156759 | 26784 | 46502476 |
Pupillary reflex impaired | 15.27 | 9.44 | 26 | 156776 | 2042 | 46527218 |
Excessive eye blinking | 15.25 | 9.44 | 14 | 156788 | 581 | 46528679 |
Asthenia | 15.24 | 9.44 | 872 | 155930 | 310203 | 46219057 |
Alveolitis | 15.24 | 9.44 | 29 | 156773 | 2484 | 46526776 |
Posterior reversible encephalopathy syndrome | 15.23 | 9.44 | 95 | 156707 | 15046 | 46514214 |
Toxicologic test abnormal | 15.17 | 9.44 | 15 | 156787 | 684 | 46528576 |
Breast cancer metastatic | 15.15 | 9.44 | 88 | 156714 | 13590 | 46515670 |
Infusion | 15.09 | 9.44 | 8 | 156794 | 133 | 46529127 |
Liver disorder | 15.05 | 9.44 | 69 | 156733 | 37177 | 46492083 |
Sternal fracture | 14.96 | 9.44 | 22 | 156780 | 1524 | 46527736 |
Injection site urticaria | 14.94 | 9.44 | 11 | 156791 | 11956 | 46517304 |
Epidural analgesia | 14.86 | 9.44 | 6 | 156796 | 51 | 46529209 |
Duodenal ulcer perforation | 14.85 | 9.44 | 5 | 156797 | 8497 | 46520763 |
Product use issue | 14.81 | 9.44 | 226 | 156576 | 94418 | 46434842 |
Thymus disorder | 14.78 | 9.44 | 9 | 156793 | 197 | 46529063 |
Neutropenic sepsis | 14.78 | 9.44 | 81 | 156721 | 12243 | 46517017 |
Visual impairment | 14.68 | 9.44 | 148 | 156654 | 66541 | 46462719 |
Cytomegalovirus infection | 14.58 | 9.44 | 24 | 156778 | 18120 | 46511140 |
Therapeutic response decreased | 14.58 | 9.44 | 85 | 156717 | 43060 | 46486200 |
Eye disorder | 14.57 | 9.44 | 24 | 156778 | 18117 | 46511143 |
Anaesthesia | 14.47 | 9.44 | 6 | 156796 | 55 | 46529205 |
Clonus | 14.46 | 9.44 | 38 | 156764 | 4042 | 46525218 |
Myelodysplastic syndrome | 14.36 | 9.44 | 19 | 156783 | 15692 | 46513568 |
Hallucination, visual | 14.31 | 9.44 | 106 | 156696 | 17767 | 46511493 |
Neuromuscular block prolonged | 14.30 | 9.44 | 13 | 156789 | 533 | 46528727 |
Intraventricular haemorrhage neonatal | 14.28 | 9.44 | 8 | 156794 | 149 | 46529111 |
Swelling | 14.25 | 9.44 | 314 | 156488 | 124197 | 46405063 |
Gastrointestinal haemorrhage | 14.16 | 9.44 | 179 | 156623 | 77194 | 46452066 |
Agonal death struggle | 14.10 | 9.44 | 3 | 156799 | 0 | 46529260 |
Infusion site granuloma | 14.10 | 9.44 | 3 | 156799 | 0 | 46529260 |
Injection site discolouration | 14.07 | 9.44 | 3 | 156799 | 6907 | 46522353 |
Sinus congestion | 13.99 | 9.44 | 14 | 156788 | 13095 | 46516165 |
Product name confusion | 13.84 | 9.44 | 6 | 156796 | 62 | 46529198 |
Encephalopathy | 13.79 | 9.44 | 173 | 156629 | 33416 | 46495844 |
PO2 decreased | 13.79 | 9.44 | 21 | 156781 | 1501 | 46527759 |
Psoriatic arthropathy | 13.77 | 9.44 | 69 | 156733 | 36310 | 46492950 |
Joint effusion | 13.76 | 9.44 | 12 | 156790 | 11983 | 46517277 |
Joint swelling | 13.70 | 9.44 | 439 | 156363 | 165634 | 46363626 |
Product use in unapproved indication | 13.64 | 9.44 | 217 | 156585 | 90056 | 46439204 |
Hip arthroplasty | 13.61 | 9.44 | 25 | 156777 | 18087 | 46511173 |
Administration site odour | 13.60 | 9.44 | 5 | 156797 | 32 | 46529228 |
Neonatal tachypnoea | 13.59 | 9.44 | 6 | 156796 | 65 | 46529195 |
Stroke volume increased | 13.55 | 9.44 | 4 | 156798 | 11 | 46529249 |
Haematoma | 13.51 | 9.44 | 58 | 156744 | 31814 | 46497446 |
Blood glucose increased | 13.40 | 9.44 | 166 | 156636 | 71847 | 46457413 |
Tubulointerstitial nephritis | 13.40 | 9.44 | 18 | 156784 | 14770 | 46514490 |
Hypercreatininaemia | 13.38 | 9.44 | 11 | 156791 | 393 | 46528867 |
Haemangioma of skin | 13.35 | 9.44 | 10 | 156792 | 311 | 46528949 |
Implant site infection | 13.25 | 9.44 | 16 | 156786 | 915 | 46528345 |
Metastasis | 13.14 | 9.44 | 38 | 156764 | 4274 | 46524986 |
Granuloma | 13.08 | 9.44 | 35 | 156767 | 3763 | 46525497 |
Transplant rejection | 13.08 | 9.44 | 8 | 156794 | 9588 | 46519672 |
Genital haemorrhage | 13.07 | 9.44 | 3 | 156799 | 6563 | 46522697 |
Pulmonary arterial hypertension | 13.05 | 9.44 | 44 | 156758 | 25884 | 46503376 |
Epidural haemorrhage | 13.01 | 9.44 | 7 | 156795 | 120 | 46529140 |
Menstruation irregular | 12.99 | 9.44 | 3 | 156799 | 6536 | 46522724 |
Neoplasm progression | 12.99 | 9.44 | 142 | 156660 | 26541 | 46502719 |
Dry eye | 12.96 | 9.44 | 55 | 156747 | 30267 | 46498993 |
C-reactive protein abnormal | 12.96 | 9.44 | 33 | 156769 | 21237 | 46508023 |
Stridor | 12.93 | 9.44 | 31 | 156771 | 3116 | 46526144 |
Muscle twitching | 12.90 | 9.44 | 89 | 156713 | 14583 | 46514677 |
Injection site cyst | 12.76 | 9.44 | 5 | 156797 | 39 | 46529221 |
Nasal disorder | 12.75 | 9.44 | 25 | 156777 | 2189 | 46527071 |
Metastases to spine | 12.68 | 9.44 | 28 | 156774 | 2666 | 46526594 |
Dose calculation error | 12.65 | 9.44 | 5 | 156797 | 40 | 46529220 |
Thirst decreased | 12.64 | 9.44 | 8 | 156794 | 188 | 46529072 |
Feeling jittery | 12.64 | 9.44 | 11 | 156791 | 10997 | 46518263 |
Ischaemic stroke | 12.63 | 9.44 | 23 | 156779 | 16699 | 46512561 |
Hepatocellular injury | 12.53 | 9.44 | 153 | 156649 | 29369 | 46499891 |
Livedo reticularis | 12.52 | 9.44 | 25 | 156777 | 2219 | 46527041 |
Spinal cord paralysis | 12.44 | 9.44 | 5 | 156797 | 42 | 46529218 |
Occupational dermatitis | 12.44 | 9.44 | 5 | 156797 | 42 | 46529218 |
Myoglobin urine | 12.41 | 9.44 | 4 | 156798 | 16 | 46529244 |
Cardiac output increased | 12.24 | 9.44 | 7 | 156795 | 136 | 46529124 |
Therapy interrupted | 12.13 | 9.44 | 11 | 156791 | 10780 | 46518480 |
Inappropriate schedule of product administration | 12.05 | 9.44 | 150 | 156652 | 64863 | 46464397 |
Self-medication | 12.03 | 9.44 | 24 | 156778 | 2128 | 46527132 |
Analgesic therapy | 12.03 | 9.44 | 3 | 156799 | 3 | 46529257 |
Back pain | 11.97 | 9.44 | 839 | 155963 | 209200 | 46320060 |
Splenic injury | 11.96 | 9.44 | 8 | 156794 | 207 | 46529053 |
Schizophrenia | 11.88 | 9.44 | 7 | 156795 | 8561 | 46520699 |
Intestinal strangulation | 11.86 | 9.44 | 6 | 156796 | 90 | 46529170 |
Sinus tachycardia | 11.85 | 9.44 | 118 | 156684 | 21531 | 46507729 |
Dyspnoea | 11.85 | 9.44 | 1534 | 155268 | 514014 | 46015246 |
Blood pressure systolic decreased | 11.78 | 9.44 | 42 | 156760 | 5276 | 46523984 |
Intentional product use issue | 11.67 | 9.44 | 117 | 156685 | 52663 | 46476597 |
Blood phosphorus decreased | 11.64 | 9.44 | 34 | 156768 | 3846 | 46525414 |
Learning disability | 11.58 | 9.44 | 6 | 156796 | 95 | 46529165 |
Brain injury | 11.49 | 9.44 | 46 | 156756 | 6104 | 46523156 |
Lupus-like syndrome | 11.47 | 9.44 | 6 | 156796 | 7838 | 46521422 |
Autoimmune hepatitis | 11.39 | 9.44 | 6 | 156796 | 7808 | 46521452 |
Myopathy | 11.30 | 9.44 | 8 | 156794 | 8873 | 46520387 |
Drug use disorder | 11.30 | 9.44 | 27 | 156775 | 2708 | 46526552 |
Dysphonia | 11.28 | 9.44 | 79 | 156723 | 38335 | 46490925 |
Rhythm idioventricular | 11.23 | 9.44 | 7 | 156795 | 160 | 46529100 |
Postoperative ileus | 11.23 | 9.44 | 11 | 156791 | 496 | 46528764 |
Sepsis neonatal | 11.23 | 9.44 | 10 | 156792 | 399 | 46528861 |
Hyponatraemia | 11.18 | 9.44 | 257 | 156545 | 101075 | 46428185 |
Skin cancer | 11.16 | 9.44 | 8 | 156794 | 8815 | 46520445 |
Fear-related avoidance of activities | 11.15 | 9.44 | 6 | 156796 | 103 | 46529157 |
Myelosuppression | 11.11 | 9.44 | 6 | 156796 | 7697 | 46521563 |
Bone marrow eosinophilic leukocyte count increased | 11.10 | 9.44 | 4 | 156798 | 24 | 46529236 |
Buttock injury | 11.10 | 9.44 | 6 | 156796 | 104 | 46529156 |
Skin lesion | 11.09 | 9.44 | 49 | 156753 | 26664 | 46502596 |
Rash pruritic | 11.07 | 9.44 | 95 | 156707 | 44120 | 46485140 |
Heat stroke | 11.07 | 9.44 | 12 | 156790 | 610 | 46528650 |
Neuropathy peripheral | 11.04 | 9.44 | 227 | 156575 | 90666 | 46438594 |
Fibromyalgia | 11.04 | 9.44 | 178 | 156624 | 36285 | 46492975 |
Paraesthesia oral | 11.01 | 9.44 | 14 | 156788 | 11759 | 46517501 |
Laryngectomy | 10.96 | 9.44 | 4 | 156798 | 25 | 46529235 |
Anaesthetic complication pulmonary | 10.95 | 9.44 | 5 | 156797 | 59 | 46529201 |
Cystitis | 10.92 | 9.44 | 90 | 156712 | 42151 | 46487109 |
Dyspepsia | 10.88 | 9.44 | 163 | 156639 | 68309 | 46460951 |
Blood pressure systolic increased | 10.87 | 9.44 | 146 | 156656 | 28641 | 46500619 |
Cardiopulmonary failure | 10.86 | 9.44 | 32 | 156770 | 3637 | 46525623 |
Suicidal ideation | 10.86 | 9.44 | 129 | 156673 | 56253 | 46473007 |
Sensory loss | 10.86 | 9.44 | 49 | 156753 | 6853 | 46522407 |
Impaired work ability | 10.83 | 9.44 | 16 | 156786 | 12620 | 46516640 |
Peritonitis bacterial | 10.74 | 9.44 | 8 | 156794 | 8645 | 46520615 |
Eye irritation | 10.73 | 9.44 | 25 | 156777 | 16589 | 46512671 |
Neurogenic shock | 10.70 | 9.44 | 8 | 156794 | 248 | 46529012 |
Metastases to oesophagus | 10.70 | 9.44 | 4 | 156798 | 27 | 46529233 |
Denture wearer | 10.68 | 9.44 | 8 | 156794 | 249 | 46529011 |
Pituitary apoplexy | 10.65 | 9.44 | 6 | 156796 | 113 | 46529147 |
Tenosynovitis | 10.62 | 9.44 | 6 | 156796 | 7509 | 46521751 |
Acne | 10.58 | 9.44 | 33 | 156769 | 19886 | 46509374 |
Pemphigoid | 10.56 | 9.44 | 3 | 156799 | 5688 | 46523572 |
Administration site haemorrhage | 10.52 | 9.44 | 5 | 156797 | 65 | 46529195 |
Phaeochromocytoma crisis | 10.47 | 9.44 | 7 | 156795 | 181 | 46529079 |
Antinuclear antibody positive | 10.44 | 9.44 | 4 | 156798 | 6276 | 46522984 |
Hyperreflexia | 10.38 | 9.44 | 40 | 156762 | 5214 | 46524046 |
Spinal cord injury | 10.34 | 9.44 | 11 | 156791 | 547 | 46528713 |
Allergic hepatitis | 10.34 | 9.44 | 4 | 156798 | 30 | 46529230 |
Parkinsonism | 10.33 | 9.44 | 7 | 156795 | 7941 | 46521319 |
Abdominal hernia | 10.27 | 9.44 | 37 | 156765 | 4671 | 46524589 |
Bone marrow failure | 10.26 | 9.44 | 58 | 156744 | 29611 | 46499649 |
Tooth hypoplasia | 10.26 | 9.44 | 5 | 156797 | 69 | 46529191 |
Ocular hyperaemia | 10.23 | 9.44 | 33 | 156769 | 19677 | 46509583 |
Incision site swelling | 10.23 | 9.44 | 4 | 156798 | 31 | 46529229 |
Rhinitis | 10.22 | 9.44 | 7 | 156795 | 7899 | 46521361 |
Nervousness | 10.22 | 9.44 | 55 | 156747 | 28420 | 46500840 |
Adiposis dolorosa | 10.20 | 9.44 | 8 | 156794 | 267 | 46528993 |
Dependence | 10.16 | 9.44 | 21 | 156781 | 1910 | 46527350 |
Spinal cord oedema | 10.16 | 9.44 | 6 | 156796 | 124 | 46529136 |
Terminal state | 10.13 | 9.44 | 23 | 156779 | 2231 | 46527029 |
Ear pain | 10.12 | 9.44 | 39 | 156763 | 22053 | 46507207 |
Foetal monitoring abnormal | 10.12 | 9.44 | 6 | 156796 | 125 | 46529135 |
Peripheral swelling | 10.08 | 9.44 | 431 | 156371 | 157640 | 46371620 |
Meningitis chemical | 10.07 | 9.44 | 6 | 156796 | 126 | 46529134 |
Cor pulmonale | 10.07 | 9.44 | 21 | 156781 | 1922 | 46527338 |
Lumbosacral plexopathy | 9.97 | 9.44 | 3 | 156799 | 9 | 46529251 |
Documented hypersensitivity to administered product | 9.91 | 9.44 | 11 | 156791 | 574 | 46528686 |
Toothache | 9.91 | 9.44 | 26 | 156776 | 16566 | 46512694 |
Hip surgery | 9.86 | 9.44 | 24 | 156778 | 2436 | 46526824 |
Bone cancer | 9.85 | 9.44 | 15 | 156787 | 1072 | 46528188 |
Lung cancer metastatic | 9.81 | 9.44 | 24 | 156778 | 2444 | 46526816 |
Troponin increased | 9.80 | 9.44 | 52 | 156750 | 7764 | 46521496 |
Hypochromasia | 9.77 | 9.44 | 8 | 156794 | 284 | 46528976 |
Body temperature increased | 9.76 | 9.44 | 127 | 156675 | 24734 | 46504526 |
Respiratory paralysis | 9.73 | 9.44 | 3 | 156799 | 10 | 46529250 |
COVID-19 | 9.71 | 9.44 | 31 | 156771 | 18544 | 46510716 |
Incorrect drug administration rate | 9.71 | 9.44 | 21 | 156781 | 1972 | 46527288 |
Vision blurred | 9.70 | 9.44 | 199 | 156603 | 79509 | 46449751 |
Haemorrhage | 9.65 | 9.44 | 128 | 156674 | 54741 | 46474519 |
Haematochezia | 9.64 | 9.44 | 80 | 156722 | 37413 | 46491847 |
Suspected suicide | 9.64 | 9.44 | 36 | 156766 | 4625 | 46524635 |
Infrequent bowel movements | 9.63 | 9.44 | 15 | 156787 | 1093 | 46528167 |
Hypoacusis | 9.62 | 9.44 | 37 | 156765 | 20932 | 46508328 |
Swelling face | 9.61 | 9.44 | 123 | 156679 | 52936 | 46476324 |
Neuralgia | 9.59 | 9.44 | 112 | 156690 | 21271 | 46507989 |
Acute kidney injury | 9.56 | 9.44 | 918 | 155884 | 234937 | 46294323 |
Prescription drug used without a prescription | 9.53 | 9.44 | 17 | 156785 | 1385 | 46527875 |
Eye swelling | 9.53 | 9.44 | 35 | 156767 | 20068 | 46509192 |
Pocket erosion | 9.51 | 9.44 | 3 | 156799 | 11 | 46529249 |
Blood creatine phosphokinase MB increased | 9.50 | 9.44 | 16 | 156786 | 1245 | 46528015 |
Hypercholesterolaemia | 9.50 | 9.44 | 15 | 156787 | 11515 | 46517745 |
Cataract | 9.50 | 9.44 | 102 | 156700 | 45313 | 46483947 |
Factitious disorder | 9.49 | 9.44 | 5 | 156797 | 82 | 46529178 |
Uveitis | 9.49 | 9.44 | 9 | 156793 | 8632 | 46520628 |
Eye pain | 9.46 | 9.44 | 55 | 156747 | 27885 | 46501375 |
Antisocial behaviour | 9.45 | 9.44 | 7 | 156795 | 214 | 46529046 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1340.07 | 10.20 | 1504 | 118005 | 67015 | 29765954 |
Toxicity to various agents | 1215.59 | 10.20 | 2370 | 117139 | 174813 | 29658156 |
Drug abuse | 1062.82 | 10.20 | 1465 | 118044 | 80607 | 29752362 |
Respiratory depression | 571.88 | 10.20 | 427 | 119082 | 11076 | 29821893 |
Overdose | 534.74 | 10.20 | 1094 | 118415 | 83243 | 29749726 |
Drug dependence | 384.00 | 10.20 | 449 | 119060 | 20846 | 29812123 |
Accidental overdose | 378.34 | 10.20 | 414 | 119095 | 17861 | 29815108 |
Substance abuse | 250.81 | 10.20 | 215 | 119294 | 6825 | 29826144 |
Miosis | 246.04 | 10.20 | 222 | 119287 | 7554 | 29825415 |
Somnolence | 227.17 | 10.20 | 874 | 118635 | 95889 | 29737080 |
Respiratory arrest | 222.15 | 10.20 | 410 | 119099 | 28848 | 29804121 |
Death | 205.28 | 10.20 | 2250 | 117259 | 355033 | 29477936 |
Unresponsive to stimuli | 175.69 | 10.20 | 350 | 119159 | 26069 | 29806900 |
Drug withdrawal syndrome | 168.82 | 10.20 | 292 | 119217 | 19517 | 29813452 |
Delirium | 166.80 | 10.20 | 445 | 119064 | 40186 | 29792783 |
Hyperaesthesia | 154.22 | 10.20 | 122 | 119387 | 3451 | 29829518 |
Pain | 149.93 | 10.20 | 1189 | 118320 | 171452 | 29661517 |
Malignant neoplasm progression | 144.14 | 10.20 | 621 | 118888 | 71666 | 29761303 |
Mental status changes | 137.20 | 10.20 | 391 | 119118 | 36688 | 29796281 |
Sedation | 136.45 | 10.20 | 239 | 119270 | 16134 | 29816835 |
Bradypnoea | 134.47 | 10.20 | 88 | 119421 | 1833 | 29831136 |
Poisoning | 130.31 | 10.20 | 192 | 119317 | 11190 | 29821779 |
Coma | 128.34 | 10.20 | 404 | 119105 | 40045 | 29792924 |
Constipation | 122.82 | 10.20 | 821 | 118688 | 112085 | 29720884 |
Confusional state | 121.00 | 10.20 | 936 | 118573 | 133898 | 29699071 |
Intentional product misuse | 119.07 | 10.20 | 356 | 119153 | 34311 | 29798658 |
Inadequate analgesia | 118.03 | 10.20 | 93 | 119416 | 2615 | 29830354 |
Acute chest syndrome | 113.34 | 10.20 | 43 | 119466 | 249 | 29832720 |
Drug screen positive | 112.99 | 10.20 | 112 | 119397 | 4295 | 29828674 |
Respiratory rate decreased | 112.29 | 10.20 | 77 | 119432 | 1738 | 29831231 |
Off label use | 112.03 | 10.20 | 563 | 118946 | 248727 | 29584242 |
Depressed level of consciousness | 109.75 | 10.20 | 369 | 119140 | 37853 | 29795116 |
Cardio-respiratory arrest | 103.40 | 10.20 | 478 | 119031 | 56828 | 29776141 |
Lethargy | 99.22 | 10.20 | 365 | 119144 | 39154 | 29793815 |
Pulmonary oedema | 97.16 | 10.20 | 390 | 119119 | 43585 | 29789384 |
Accidental death | 94.07 | 10.20 | 73 | 119436 | 2006 | 29830963 |
Cardiac arrest | 87.36 | 10.20 | 652 | 118857 | 92198 | 29740771 |
Drug abuser | 86.37 | 10.20 | 97 | 119412 | 4304 | 29828665 |
Myocardial infarction | 84.04 | 10.20 | 241 | 119268 | 125384 | 29707585 |
Completed suicide | 81.16 | 10.20 | 676 | 118833 | 98816 | 29734153 |
Withdrawal syndrome | 80.79 | 10.20 | 154 | 119355 | 11096 | 29821873 |
Apnoea | 75.16 | 10.20 | 108 | 119401 | 6150 | 29826819 |
Vomiting | 72.35 | 10.20 | 1255 | 118254 | 218563 | 29614406 |
Agitation | 70.44 | 10.20 | 412 | 119097 | 53661 | 29779308 |
Asphyxia | 68.67 | 10.20 | 96 | 119413 | 5329 | 29827640 |
Cardiac failure congestive | 68.07 | 10.20 | 147 | 119362 | 84260 | 29748709 |
Myalgia | 63.09 | 10.20 | 132 | 119377 | 76535 | 29756434 |
Product dose omission issue | 62.56 | 10.20 | 174 | 119335 | 91457 | 29741512 |
Drug ineffective | 59.28 | 10.20 | 979 | 118530 | 339408 | 29493561 |
Product use in unapproved indication | 57.23 | 10.20 | 131 | 119378 | 73562 | 29759407 |
Cytomegalovirus infection | 55.70 | 10.20 | 13 | 119496 | 23661 | 29809308 |
Brain oedema | 54.11 | 10.20 | 139 | 119370 | 12259 | 29820710 |
Nausea | 53.17 | 10.20 | 1555 | 117954 | 295402 | 29537567 |
Sedation complication | 50.69 | 10.20 | 35 | 119474 | 799 | 29832170 |
Coronary artery disease | 46.68 | 10.20 | 79 | 119430 | 49633 | 29783336 |
Hypogonadism male | 45.60 | 10.20 | 22 | 119487 | 246 | 29832723 |
Hypoxia | 44.92 | 10.20 | 336 | 119173 | 47518 | 29785451 |
Cerebrovascular accident | 44.27 | 10.20 | 177 | 119332 | 83300 | 29749669 |
Myoclonus | 44.07 | 10.20 | 135 | 119374 | 13177 | 29819792 |
Renal impairment | 43.70 | 10.20 | 180 | 119329 | 84004 | 29748965 |
Oxygen saturation decreased | 43.64 | 10.20 | 310 | 119199 | 43130 | 29789839 |
Pulmonary congestion | 42.94 | 10.20 | 127 | 119382 | 12160 | 29820809 |
Cancer pain | 42.17 | 10.20 | 51 | 119458 | 2451 | 29830518 |
Cough | 41.98 | 10.20 | 311 | 119198 | 125331 | 29707638 |
Dizziness | 40.22 | 10.20 | 542 | 118967 | 194367 | 29638602 |
Psoriasis | 39.49 | 10.20 | 68 | 119441 | 42438 | 29790531 |
Hypoventilation | 39.01 | 10.20 | 54 | 119455 | 2969 | 29830000 |
Drug resistance | 38.53 | 10.20 | 16 | 119493 | 20117 | 29812852 |
Syncope | 38.41 | 10.20 | 191 | 119318 | 84712 | 29748257 |
Exposure via ingestion | 37.29 | 10.20 | 49 | 119460 | 2562 | 29830407 |
Pneumonia aspiration | 37.01 | 10.20 | 268 | 119241 | 37512 | 29795457 |
Treatment failure | 36.50 | 10.20 | 51 | 119458 | 34628 | 29798341 |
Hypoxic-ischaemic encephalopathy | 35.94 | 10.20 | 66 | 119443 | 4621 | 29828348 |
Diarrhoea | 34.99 | 10.20 | 1041 | 118468 | 333062 | 29499907 |
Foetal exposure during pregnancy | 34.24 | 10.20 | 59 | 119450 | 36812 | 29796157 |
Breakthrough pain | 33.97 | 10.20 | 24 | 119485 | 569 | 29832400 |
Melaena | 33.84 | 10.20 | 48 | 119461 | 32389 | 29800580 |
Headache | 33.38 | 10.20 | 519 | 118990 | 181787 | 29651182 |
Drug use disorder | 33.22 | 10.20 | 52 | 119457 | 3196 | 29829773 |
Metastases to bone | 32.96 | 10.20 | 99 | 119410 | 9559 | 29823410 |
Sphincter of Oddi dysfunction | 32.35 | 10.20 | 14 | 119495 | 119 | 29832850 |
Serotonin syndrome | 32.05 | 10.20 | 149 | 119360 | 17742 | 29815227 |
Hospitalisation | 31.85 | 10.20 | 82 | 119427 | 44237 | 29788732 |
Urinary retention | 31.38 | 10.20 | 232 | 119277 | 32685 | 29800284 |
Blood pH decreased | 31.13 | 10.20 | 42 | 119467 | 2253 | 29830716 |
Diaphragmatic spasm | 30.21 | 10.20 | 12 | 119497 | 80 | 29832889 |
Leukopenia | 29.81 | 10.20 | 119 | 119390 | 56040 | 29776929 |
Faecal volume decreased | 29.72 | 10.20 | 12 | 119497 | 84 | 29832885 |
Visual acuity reduced | 29.67 | 10.20 | 13 | 119496 | 15833 | 29817136 |
Respiratory acidosis | 29.52 | 10.20 | 57 | 119452 | 4145 | 29828824 |
Dyspnoea | 29.29 | 10.20 | 1062 | 118447 | 332233 | 29500736 |
Drug eruption | 28.90 | 10.20 | 17 | 119492 | 17509 | 29815460 |
Drug tolerance | 28.47 | 10.20 | 39 | 119470 | 2123 | 29830846 |
Respiratory distress | 28.43 | 10.20 | 227 | 119282 | 32745 | 29800224 |
Diabetes mellitus inadequate control | 28.12 | 10.20 | 8 | 119501 | 12754 | 29820215 |
Hallucination | 27.87 | 10.20 | 309 | 119200 | 48750 | 29784219 |
Haematuria | 27.79 | 10.20 | 89 | 119420 | 44745 | 29788224 |
Sinus tachycardia | 27.69 | 10.20 | 129 | 119380 | 15375 | 29817594 |
Disease progression | 27.23 | 10.20 | 459 | 119050 | 79415 | 29753554 |
Hyperhidrosis | 27.22 | 10.20 | 397 | 119112 | 66693 | 29766276 |
Fatigue | 27.00 | 10.20 | 1027 | 118482 | 319646 | 29513323 |
Drug diversion | 26.73 | 10.20 | 25 | 119484 | 891 | 29832078 |
PCO2 increased | 26.09 | 10.20 | 21 | 119488 | 609 | 29832360 |
Tubulointerstitial nephritis | 25.95 | 10.20 | 20 | 119489 | 17871 | 29815098 |
Hypertension | 25.89 | 10.20 | 335 | 119174 | 121019 | 29711950 |
Glycosylated haemoglobin increased | 24.88 | 10.20 | 4 | 119505 | 9487 | 29823482 |
Atrial fibrillation | 24.75 | 10.20 | 294 | 119215 | 107830 | 29725139 |
Blood glucose increased | 24.72 | 10.20 | 144 | 119365 | 61386 | 29771583 |
Basal cell carcinoma | 24.55 | 10.20 | 17 | 119492 | 16051 | 29816918 |
Toxicologic test abnormal | 24.47 | 10.20 | 20 | 119489 | 593 | 29832376 |
Hepatic function abnormal | 24.13 | 10.20 | 86 | 119423 | 41859 | 29791110 |
Self-medication | 23.84 | 10.20 | 37 | 119472 | 2257 | 29830712 |
Opiates positive | 23.18 | 10.20 | 14 | 119495 | 252 | 29832717 |
Cardiac failure | 23.07 | 10.20 | 217 | 119292 | 83201 | 29749768 |
Weight increased | 22.86 | 10.20 | 190 | 119319 | 74723 | 29758246 |
Drug level | 22.64 | 10.20 | 5 | 119504 | 0 | 29832969 |
Lung cancer metastatic | 22.49 | 10.20 | 38 | 119471 | 2490 | 29830479 |
Postoperative ileus | 22.49 | 10.20 | 20 | 119489 | 667 | 29832302 |
Chronic kidney disease | 22.15 | 10.20 | 77 | 119432 | 37761 | 29795208 |
Arthralgia | 22.07 | 10.20 | 395 | 119114 | 135396 | 29697573 |
Peritonitis bacterial | 21.84 | 10.20 | 9 | 119500 | 11369 | 29821600 |
Angina unstable | 21.66 | 10.20 | 11 | 119498 | 12299 | 29820670 |
Intestinal obstruction | 21.60 | 10.20 | 141 | 119368 | 19071 | 29813898 |
Secondary hypogonadism | 21.42 | 10.20 | 14 | 119495 | 291 | 29832678 |
Neoplasm progression | 21.33 | 10.20 | 134 | 119375 | 17889 | 29815080 |
Clumsiness | 21.33 | 10.20 | 27 | 119482 | 1360 | 29831609 |
Tumour pain | 21.28 | 10.20 | 23 | 119486 | 977 | 29831992 |
Muscle swelling | 21.07 | 10.20 | 15 | 119494 | 360 | 29832609 |
Bladder dilatation | 20.91 | 10.20 | 26 | 119483 | 1286 | 29831683 |
Orthostatic hypotension | 20.81 | 10.20 | 40 | 119469 | 23939 | 29809030 |
Anaemia | 20.73 | 10.20 | 652 | 118857 | 207340 | 29625629 |
Aspiration | 20.49 | 10.20 | 90 | 119419 | 10461 | 29822508 |
Spinal cord compression | 20.20 | 10.20 | 45 | 119464 | 3621 | 29829348 |
Medication error | 20.09 | 10.20 | 148 | 119361 | 20824 | 29812145 |
Eosinophilia | 20.08 | 10.20 | 36 | 119473 | 22124 | 29810845 |
Abdominal compartment syndrome | 20.05 | 10.20 | 21 | 119488 | 860 | 29832109 |
Bone marrow failure | 19.98 | 10.20 | 57 | 119452 | 29728 | 29803241 |
Drug-induced liver injury | 19.79 | 10.20 | 34 | 119475 | 21240 | 29811729 |
Interstitial lung disease | 19.13 | 10.20 | 151 | 119358 | 60046 | 29772923 |
Device failure | 18.73 | 10.20 | 32 | 119477 | 2116 | 29830853 |
Back pain | 18.72 | 10.20 | 539 | 118970 | 102057 | 29730912 |
Neutropenia | 18.70 | 10.20 | 381 | 119128 | 128159 | 29704810 |
Weaning failure | 18.33 | 10.20 | 12 | 119497 | 250 | 29832719 |
Hypopnoea | 18.22 | 10.20 | 23 | 119486 | 1155 | 29831814 |
Fall | 18.14 | 10.20 | 570 | 118939 | 181302 | 29651667 |
Neuroleptic malignant syndrome | 18.12 | 10.20 | 23 | 119486 | 16272 | 29816697 |
Sinusitis | 18.11 | 10.20 | 70 | 119439 | 33275 | 29799694 |
Angina pectoris | 18.01 | 10.20 | 59 | 119450 | 29459 | 29803510 |
Poisoning deliberate | 17.82 | 10.20 | 58 | 119451 | 5846 | 29827123 |
Hepatic enzyme increased | 17.75 | 10.20 | 71 | 119438 | 33423 | 29799546 |
Hypoglycaemia | 17.57 | 10.20 | 125 | 119384 | 50856 | 29782113 |
Progressive multifocal leukoencephalopathy | 17.51 | 10.20 | 7 | 119502 | 9006 | 29823963 |
Neuropathy peripheral | 17.14 | 10.20 | 189 | 119320 | 70286 | 29762683 |
Stupor | 17.13 | 10.20 | 37 | 119472 | 2916 | 29830053 |
Plasma cell myeloma | 17.05 | 10.20 | 304 | 119205 | 53158 | 29779811 |
Post procedural complication | 17.01 | 10.20 | 92 | 119417 | 11634 | 29821335 |
Pupil fixed | 16.92 | 10.20 | 28 | 119481 | 1804 | 29831165 |
Blood cholesterol increased | 16.83 | 10.20 | 26 | 119483 | 16944 | 29816025 |
Gout | 16.73 | 10.20 | 27 | 119482 | 17288 | 29815681 |
Haematochezia | 16.62 | 10.20 | 75 | 119434 | 34147 | 29798822 |
Muscle spasticity | 16.60 | 10.20 | 52 | 119457 | 5136 | 29827833 |
Transplant rejection | 16.54 | 10.20 | 8 | 119501 | 9198 | 29823771 |
Vein collapse | 16.43 | 10.20 | 7 | 119502 | 57 | 29832912 |
Transient ischaemic attack | 16.34 | 10.20 | 49 | 119460 | 25151 | 29807818 |
Diabetic ketoacidosis | 16.33 | 10.20 | 24 | 119485 | 15962 | 29817007 |
Acute myocardial infarction | 16.27 | 10.20 | 134 | 119375 | 52805 | 29780164 |
Immune reconstitution inflammatory syndrome | 16.21 | 10.20 | 8 | 119501 | 9093 | 29823876 |
Visceral congestion | 16.17 | 10.20 | 15 | 119494 | 529 | 29832440 |
Sickle cell anaemia with crisis | 16.17 | 10.20 | 32 | 119477 | 2370 | 29830599 |
Glomerular filtration rate decreased | 16.10 | 10.20 | 13 | 119496 | 11349 | 29821620 |
Allodynia | 16.06 | 10.20 | 16 | 119493 | 617 | 29832352 |
Abdominal pain | 16.06 | 10.20 | 678 | 118831 | 134976 | 29697993 |
Dependence | 15.97 | 10.20 | 22 | 119487 | 1204 | 29831765 |
Swelling of eyelid | 15.49 | 10.20 | 12 | 119497 | 329 | 29832640 |
Asthma | 15.43 | 10.20 | 83 | 119426 | 36091 | 29796878 |
Hypertensive crisis | 15.42 | 10.20 | 7 | 119502 | 8350 | 29824619 |
Substance dependence | 15.42 | 10.20 | 13 | 119496 | 403 | 29832566 |
Post laminectomy syndrome | 15.38 | 10.20 | 10 | 119499 | 206 | 29832763 |
Substance use disorder | 15.33 | 10.20 | 8 | 119501 | 107 | 29832862 |
Cluster headache | 15.31 | 10.20 | 15 | 119494 | 567 | 29832402 |
Decerebration | 15.30 | 10.20 | 5 | 119504 | 17 | 29832952 |
Diabetes mellitus | 15.24 | 10.20 | 101 | 119408 | 41764 | 29791205 |
Injection site swelling | 15.22 | 10.20 | 8 | 119501 | 8772 | 29824197 |
Accidental poisoning | 15.18 | 10.20 | 14 | 119495 | 490 | 29832479 |
Photosensitivity reaction | 15.16 | 10.20 | 10 | 119499 | 9684 | 29823285 |
Ischaemic stroke | 15.15 | 10.20 | 26 | 119483 | 16249 | 29816720 |
Prescribed underdose | 15.12 | 10.20 | 6 | 119503 | 7753 | 29825216 |
Apnoeic attack | 14.96 | 10.20 | 11 | 119498 | 278 | 29832691 |
Infusion site granuloma | 14.89 | 10.20 | 4 | 119505 | 5 | 29832964 |
Hypercapnia | 14.79 | 10.20 | 41 | 119468 | 3783 | 29829186 |
Intensive care | 14.73 | 10.20 | 11 | 119498 | 285 | 29832684 |
Electrocardiogram low voltage | 14.67 | 10.20 | 5 | 119504 | 20 | 29832949 |
Nerve injury | 14.66 | 10.20 | 35 | 119474 | 2948 | 29830021 |
Schizophrenia | 14.60 | 10.20 | 9 | 119500 | 9039 | 29823930 |
Infective pulmonary exacerbation of cystic fibrosis | 14.58 | 10.20 | 8 | 119501 | 8564 | 29824405 |
Accidental exposure to product by child | 14.58 | 10.20 | 24 | 119485 | 1539 | 29831430 |
Salivary hypersecretion | 14.50 | 10.20 | 6 | 119503 | 7560 | 29825409 |
Encephalopathy | 14.43 | 10.20 | 194 | 119315 | 32011 | 29800958 |
Cerebrospinal fluid leakage | 14.43 | 10.20 | 13 | 119496 | 441 | 29832528 |
Blood triglycerides increased | 14.36 | 10.20 | 21 | 119488 | 13996 | 29818973 |
Metastases to lung | 14.32 | 10.20 | 66 | 119443 | 7829 | 29825140 |
Carcinoid crisis | 14.27 | 10.20 | 10 | 119499 | 234 | 29832735 |
Haemophagocytic lymphohistiocytosis | 14.13 | 10.20 | 11 | 119498 | 9780 | 29823189 |
Intentional misuse of drug delivery system | 14.09 | 10.20 | 4 | 119505 | 7 | 29832962 |
Psychomotor skills impaired | 14.09 | 10.20 | 27 | 119482 | 1952 | 29831017 |
Depression | 14.07 | 10.20 | 265 | 119244 | 90172 | 29742797 |
Victim of homicide | 13.96 | 10.20 | 8 | 119501 | 130 | 29832839 |
Myopathy | 13.92 | 10.20 | 13 | 119496 | 10573 | 29822396 |
Cerebral infarction | 13.91 | 10.20 | 56 | 119453 | 26317 | 29806652 |
Disability | 13.88 | 10.20 | 44 | 119465 | 4374 | 29828595 |
Rash | 13.87 | 10.20 | 625 | 118884 | 191264 | 29641705 |
Incoherent | 13.85 | 10.20 | 42 | 119467 | 4076 | 29828893 |
C-reactive protein increased | 13.83 | 10.20 | 109 | 119400 | 43364 | 29789605 |
Tooth injury | 13.82 | 10.20 | 16 | 119493 | 734 | 29832235 |
Condition aggravated | 13.75 | 10.20 | 432 | 119077 | 137434 | 29695535 |
Medical device site bruise | 13.75 | 10.20 | 4 | 119505 | 8 | 29832961 |
Arrhythmia neonatal | 13.58 | 10.20 | 3 | 119506 | 0 | 29832969 |
Opiates | 13.58 | 10.20 | 3 | 119506 | 0 | 29832969 |
Medical device site haemorrhage | 13.54 | 10.20 | 8 | 119501 | 138 | 29832831 |
Multiple sclerosis relapse | 13.52 | 10.20 | 14 | 119495 | 10848 | 29822121 |
Biliary obstruction | 13.39 | 10.20 | 30 | 119479 | 2423 | 29830546 |
White blood cell count decreased | 13.37 | 10.20 | 245 | 119264 | 83702 | 29749267 |
Therapy cessation | 13.35 | 10.20 | 25 | 119484 | 15112 | 29817857 |
Infusion site urticaria | 13.26 | 10.20 | 7 | 119502 | 96 | 29832873 |
Blood creatinine increased | 13.23 | 10.20 | 271 | 119238 | 91104 | 29741865 |
Monocytopenia | 13.19 | 10.20 | 7 | 119502 | 97 | 29832872 |
Tuberculosis | 13.08 | 10.20 | 8 | 119501 | 8069 | 29824900 |
Acute pulmonary oedema | 13.03 | 10.20 | 62 | 119447 | 7453 | 29825516 |
Brain injury | 12.88 | 10.20 | 50 | 119459 | 5498 | 29827471 |
Small intestinal obstruction | 12.86 | 10.20 | 96 | 119413 | 13563 | 29819406 |
Accidental underdose | 12.80 | 10.20 | 11 | 119498 | 350 | 29832619 |
Neutrophil count decreased | 12.80 | 10.20 | 108 | 119401 | 42346 | 29790623 |
Product residue present | 12.71 | 10.20 | 31 | 119478 | 2647 | 29830322 |
Eosinophilic myocarditis | 12.66 | 10.20 | 12 | 119497 | 435 | 29832534 |
Dyspnoea exertional | 12.64 | 10.20 | 86 | 119423 | 35344 | 29797625 |
Head injury | 12.61 | 10.20 | 31 | 119478 | 16989 | 29815980 |
Pulmonary haemorrhage | 12.50 | 10.20 | 72 | 119437 | 9320 | 29823649 |
Drug intolerance | 12.43 | 10.20 | 118 | 119391 | 45173 | 29787796 |
Blood pH increased | 12.42 | 10.20 | 15 | 119494 | 720 | 29832249 |
Pupils unequal | 12.39 | 10.20 | 20 | 119489 | 1262 | 29831707 |
Visual impairment | 12.35 | 10.20 | 71 | 119438 | 30367 | 29802602 |
Nephrotic syndrome | 12.35 | 10.20 | 6 | 119503 | 6879 | 29826090 |
Proteinuria | 12.28 | 10.20 | 29 | 119480 | 16116 | 29816853 |
Cheyne-Stokes respiration | 12.22 | 10.20 | 9 | 119500 | 228 | 29832741 |
Palpitations | 12.22 | 10.20 | 81 | 119428 | 33492 | 29799477 |
Dyspepsia | 12.16 | 10.20 | 71 | 119438 | 30258 | 29802711 |
Injection site reaction | 12.16 | 10.20 | 15 | 119494 | 10745 | 29822224 |
Needle track marks | 12.15 | 10.20 | 4 | 119505 | 14 | 29832955 |
Dose calculation error | 12.15 | 10.20 | 5 | 119504 | 37 | 29832932 |
Necrotising colitis | 11.95 | 10.20 | 17 | 119492 | 959 | 29832010 |
Parathyroid hormone-related protein abnormal | 11.94 | 10.20 | 4 | 119505 | 15 | 29832954 |
Brain death | 11.88 | 10.20 | 29 | 119480 | 2477 | 29830492 |
Paraparesis | 11.85 | 10.20 | 24 | 119485 | 1807 | 29831162 |
Large intestine perforation | 11.76 | 10.20 | 61 | 119448 | 7590 | 29825379 |
Hypercholesterolaemia | 11.64 | 10.20 | 8 | 119501 | 7584 | 29825385 |
Respiratory rate increased | 11.64 | 10.20 | 68 | 119441 | 8847 | 29824122 |
Mydriasis | 11.63 | 10.20 | 52 | 119457 | 6091 | 29826878 |
Disorientation | 11.60 | 10.20 | 183 | 119326 | 31235 | 29801734 |
Haemorrhagic stroke | 11.58 | 10.20 | 5 | 119504 | 6142 | 29826827 |
Hypersensitivity | 11.56 | 10.20 | 149 | 119360 | 53879 | 29779090 |
Intervertebral disc injury | 11.55 | 10.20 | 4 | 119505 | 17 | 29832952 |
Lactic acidosis | 11.51 | 10.20 | 75 | 119434 | 31138 | 29801831 |
Exposure during pregnancy | 11.46 | 10.20 | 12 | 119497 | 9249 | 29823720 |
Peripheral swelling | 11.44 | 10.20 | 173 | 119336 | 60901 | 29772068 |
COVID-19 | 11.42 | 10.20 | 35 | 119474 | 17843 | 29815126 |
Blood count abnormal | 11.41 | 10.20 | 18 | 119491 | 11634 | 29821335 |
Secondary adrenocortical insufficiency | 11.41 | 10.20 | 17 | 119492 | 1000 | 29831969 |
Foaming at mouth | 11.31 | 10.20 | 14 | 119495 | 689 | 29832280 |
Perineal pain | 11.30 | 10.20 | 13 | 119496 | 592 | 29832377 |
Cyanosis | 11.30 | 10.20 | 84 | 119425 | 11851 | 29821118 |
Eosinophil count increased | 11.29 | 10.20 | 8 | 119501 | 7465 | 29825504 |
Nasopharyngitis | 11.26 | 10.20 | 166 | 119343 | 58683 | 29774286 |
Injection site erythema | 11.21 | 10.20 | 24 | 119485 | 13810 | 29819159 |
Narcotic bowel syndrome | 11.21 | 10.20 | 7 | 119502 | 134 | 29832835 |
Liver disorder | 11.18 | 10.20 | 71 | 119438 | 29651 | 29803318 |
Cataract | 11.12 | 10.20 | 47 | 119462 | 21788 | 29811181 |
Pupillary reflex impaired | 11.03 | 10.20 | 21 | 119488 | 1511 | 29831458 |
Scan gallium abnormal | 11.03 | 10.20 | 4 | 119505 | 20 | 29832949 |
Jaundice | 11.02 | 10.20 | 80 | 119429 | 32406 | 29800563 |
Herpes zoster | 11.02 | 10.20 | 72 | 119437 | 29871 | 29803098 |
Needle issue | 10.99 | 10.20 | 37 | 119472 | 3795 | 29829174 |
Anamnestic reaction | 10.94 | 10.20 | 5 | 119504 | 49 | 29832920 |
Conjunctival discolouration | 10.87 | 10.20 | 4 | 119505 | 21 | 29832948 |
Paraplegia | 10.76 | 10.20 | 29 | 119480 | 2632 | 29830337 |
Device computer issue | 10.71 | 10.20 | 4 | 119505 | 22 | 29832947 |
Neuralgia | 10.68 | 10.20 | 75 | 119434 | 10391 | 29822578 |
Synovitis | 10.68 | 10.20 | 14 | 119495 | 9769 | 29823200 |
Tachyphylaxis | 10.66 | 10.20 | 6 | 119503 | 94 | 29832875 |
Apparent life threatening event | 10.59 | 10.20 | 8 | 119501 | 211 | 29832758 |
Infusion related reaction | 10.58 | 10.20 | 107 | 119402 | 40457 | 29792512 |
Loss of personal independence in daily activities | 10.57 | 10.20 | 47 | 119462 | 21488 | 29811481 |
Blood pressure diastolic decreased | 10.51 | 10.20 | 51 | 119458 | 6180 | 29826789 |
Cardiac disorder | 10.50 | 10.20 | 105 | 119404 | 39788 | 29793181 |
Medical device site infection | 10.46 | 10.20 | 8 | 119501 | 215 | 29832754 |
Abdominal pain upper | 10.45 | 10.20 | 181 | 119328 | 62370 | 29770599 |
Wrong technique in product usage process | 10.44 | 10.20 | 77 | 119432 | 31078 | 29801891 |
Prostate cancer metastatic | 10.44 | 10.20 | 44 | 119465 | 5023 | 29827946 |
General physical health deterioration | 10.38 | 10.20 | 493 | 119016 | 99451 | 29733518 |
Renal failure | 10.36 | 10.20 | 415 | 119094 | 128551 | 29704418 |
Ventricular asystole | 10.32 | 10.20 | 7 | 119502 | 155 | 29832814 |
Performance status decreased | 10.30 | 10.20 | 37 | 119472 | 3920 | 29829049 |
Learning disability | 10.28 | 10.20 | 7 | 119502 | 156 | 29832813 |
Source | Code | Description |
---|---|---|
ATC | N02AA01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | A07DA52 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS ANTIPROPULSIVES Antipropulsives |
ATC | N02AA51 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AG01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with antispasmodics |
ATC | R05DA05 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35482 | narcotic analgesics |
CHEBI has role | CHEBI:35620 | vasodilator |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:38867 | anaesthetic |
CHEBI has role | CHEBI:55322 | mu opioid agonist |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
General anesthesia | indication | 50697003 | |
Diarrhea | indication | 62315008 | |
Severe pain | indication | 76948002 | |
Chronic pain | indication | 82423001 | |
Local anesthesia | indication | 386761002 | |
Acute postoperative pain | indication | 107401000119105 | |
Regional Anesthesia for Surgery | indication | ||
Regional Anesthesia for Labor Pain | indication | ||
Chronic Pain with Opioid Tolerance | indication | ||
Neuropathic pain | off-label use | 247398009 | |
Neonatal Abstinence Syndrome | off-label use | 414819007 | DOID:9828 |
Sedation in Intubated Patients | off-label use | ||
Neonatal Opioid Dependence | off-label use | ||
Brain damage | contraindication | 2470005 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Tachyarrhythmia | contraindication | 6285003 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Dyskinesia | contraindication | 9748009 | |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Acute vomiting | contraindication | 23971007 | |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Orthostatic hypotension | contraindication | 28651003 | |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Torsades de pointes | contraindication | 31722008 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Psychotic disorder | contraindication | 69322001 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Urethral stricture | contraindication | 76618002 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Prolonged QT interval | contraindication | 111975006 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Hypomagnesemia | contraindication | 190855004 | |
Alcohol withdrawal syndrome | contraindication | 191480000 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Chronic diarrhea | contraindication | 236071009 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Drowsy | contraindication | 271782001 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Central nervous system depression | contraindication | 418072004 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Predisposition to Nausea and Vomiting | contraindication | ||
Progressive Angina Pectoris | contraindication | ||
Severe Nausea | contraindication | ||
Pain in Opioid Naive Patients | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.71 | acidic |
pKa2 | 8.38 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
15MG | MORPHINE SULFATE | ALKEM LABS LTD | A212451 | Dec. 3, 2020 | RX | TABLET | ORAL | Aug. 10, 2021 | COMPETITIVE GENERIC THERAPY |
30MG | MORPHINE SULFATE | ALKEM LABS LTD | A212451 | Dec. 3, 2020 | RX | TABLET | ORAL | Aug. 10, 2021 | COMPETITIVE GENERIC THERAPY |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | EC50 | 7.86 | WOMBAT-PK | CHEMBL | |||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.55 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 6.62 | WOMBAT-PK | |||||
Kappa-type opioid receptor | GPCR | Ki | 6.97 | WOMBAT-PK | |||||
Mu-type opioid receptor | GPCR | Ki | 9.11 | CHEMBL | |||||
Dopamine receptor | GPCR | IC50 | 8.27 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.62 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 7 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 8.92 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.57 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 8.74 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.30 | CHEMBL | |||||
Nociceptin receptor | GPCR | Ki | 7.86 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.06 | CHEMBL | |||||
Opioid receptor | GPCR | IC50 | 7.57 | CHEMBL | |||||
Opioid receptor | GPCR | Ki | 8.22 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 6.52 | CHEMBL | |||||
Mu opioid receptor-like OR2 | Unclassified | Ki | 6.73 | CHEMBL |
ID | Source |
---|---|
D00842 | KEGG_DRUG |
52-26-6 | SECONDARY_CAS_RN |
4017470 | VANDF |
4017530 | VANDF |
C0026549 | UMLSCUI |
CHEBI:17303 | CHEBI |
MOI | PDB_CHEM_ID |
CHEMBL70 | ChEMBL_ID |
CHEMBL556578 | ChEMBL_ID |
CHEMBL2103744 | ChEMBL_ID |
CHEMBL2096625 | ChEMBL_ID |
D009020 | MESH_DESCRIPTOR_UI |
DB00295 | DRUGBANK_ID |
1627 | IUPHAR_LIGAND_ID |
76I7G6D29C | UNII |
5288826 | PUBCHEM_CID |
235751 | RXNORM |
15239 | MMSL |
18643 | MMSL |
1913 | MMSL |
5136 | MMSL |
d00308 | MMSL |
d05295 | MMSL |
001545 | NDDF |
001546 | NDDF |
003523 | NDDF |
373529000 | SNOMEDCT_US |
395804007 | SNOMEDCT_US |
60886004 | SNOMEDCT_US |
73572009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6011 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6012 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6013 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6014 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6015 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6016 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6017 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6018 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6019 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | NDA | 34 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0235 | TABLET | 15 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0236 | TABLET | 30 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0237 | SOLUTION | 10 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0238 | SOLUTION | 20 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0404 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0517 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1277 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1278 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1279 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1280 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1281 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1282 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1479 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0825 | SOLUTION | 100 mg | ORAL | ANDA | 34 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0904 | SOLUTION | 10 mg | ORAL | NDA | 32 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3090 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 34 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3091 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 34 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3092 | CAPSULE, EXTENDED RELEASE | 90 mg | ORAL | ANDA | 34 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3093 | CAPSULE, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 34 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3116 | CAPSULE, EXTENDED RELEASE | 45 mg | ORAL | ANDA | 34 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3117 | CAPSULE, EXTENDED RELEASE | 75 mg | ORAL | ANDA | 34 sections |