Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor antagonists/agonists, morphinan derivates | 1845 | 57-27-2 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
30 | mg | P |
30 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 57.14 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.85 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 24 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.65 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 6898.80 | 9.37 | 6233 | 172239 | 244777 | 50181875 |
Drug abuse | 1076.72 | 9.37 | 1187 | 177285 | 58659 | 50367993 |
Toxicity to various agents | 819.41 | 9.37 | 2101 | 176371 | 210398 | 50216254 |
Death | 439.99 | 9.37 | 2285 | 176187 | 323094 | 50103558 |
Respiratory depression | 406.60 | 9.37 | 338 | 178134 | 11672 | 50414980 |
Overdose | 405.20 | 9.37 | 1007 | 177465 | 98720 | 50327932 |
Sedation | 402.79 | 9.37 | 518 | 177954 | 30092 | 50396560 |
Respiratory arrest | 365.65 | 9.37 | 489 | 177983 | 29520 | 50397132 |
Accidental overdose | 357.04 | 9.37 | 391 | 178081 | 19142 | 50407510 |
Depressed level of consciousness | 330.60 | 9.37 | 629 | 177843 | 51324 | 50375328 |
Constipation | 290.81 | 9.37 | 1361 | 177111 | 184347 | 50242305 |
Sedation complication | 284.94 | 9.37 | 241 | 178231 | 8525 | 50418127 |
Drug dependence | 284.79 | 9.37 | 350 | 178122 | 19409 | 50407243 |
Pemphigus | 254.84 | 9.37 | 56 | 178416 | 120110 | 50306542 |
Creatinine renal clearance decreased | 254.80 | 9.37 | 259 | 178213 | 11622 | 50415030 |
Systemic lupus erythematosus | 251.10 | 9.37 | 91 | 178381 | 140531 | 50286121 |
Miosis | 250.58 | 9.37 | 195 | 178277 | 6115 | 50420537 |
Alopecia | 247.70 | 9.37 | 300 | 178172 | 244747 | 50181905 |
Somnolence | 239.69 | 9.37 | 1132 | 177340 | 153853 | 50272799 |
Glossodynia | 219.94 | 9.37 | 67 | 178405 | 115502 | 50311150 |
Completed suicide | 212.47 | 9.37 | 975 | 177497 | 130914 | 50295738 |
Arthropathy | 197.79 | 9.37 | 160 | 178312 | 157746 | 50268906 |
Blood calcium decreased | 187.25 | 9.37 | 293 | 178179 | 20413 | 50406239 |
Cardiac arrest | 184.95 | 9.37 | 682 | 177790 | 82969 | 50343683 |
Drug withdrawal syndrome | 183.95 | 9.37 | 323 | 178149 | 24758 | 50401894 |
Vomiting | 181.20 | 9.37 | 2446 | 176026 | 458312 | 49968340 |
Hypotension | 178.07 | 9.37 | 1429 | 177043 | 234040 | 50192612 |
Coma | 176.20 | 9.37 | 520 | 177952 | 56359 | 50370293 |
Cardio-respiratory arrest | 175.90 | 9.37 | 502 | 177970 | 53390 | 50373262 |
Abdominal discomfort | 170.03 | 9.37 | 351 | 178121 | 231290 | 50195362 |
Contrast media allergy | 163.13 | 9.37 | 97 | 178375 | 1930 | 50424722 |
Bradypnoea | 162.75 | 9.37 | 113 | 178359 | 2961 | 50423691 |
Unresponsive to stimuli | 160.48 | 9.37 | 342 | 178130 | 30267 | 50396385 |
Respiratory rate decreased | 156.97 | 9.37 | 111 | 178361 | 2997 | 50423655 |
Substance abuse | 152.05 | 9.37 | 122 | 178350 | 4002 | 50422650 |
Orthostatic hypotension | 148.37 | 9.37 | 324 | 178148 | 29157 | 50397495 |
Hand deformity | 147.46 | 9.37 | 85 | 178387 | 100114 | 50326538 |
Hyperaesthesia | 129.59 | 9.37 | 152 | 178320 | 8021 | 50418631 |
Inadequate analgesia | 119.21 | 9.37 | 87 | 178385 | 2471 | 50424181 |
Pericarditis | 115.42 | 9.37 | 67 | 178405 | 78622 | 50348030 |
Myoclonus | 114.82 | 9.37 | 193 | 178279 | 14277 | 50412375 |
Sinusitis | 114.75 | 9.37 | 271 | 178201 | 170287 | 50256365 |
Cognitive disorder | 114.13 | 9.37 | 379 | 178093 | 43744 | 50382908 |
Anti-cyclic citrullinated peptide antibody positive | 112.53 | 9.37 | 54 | 178418 | 70533 | 50356119 |
Arthralgia | 112.48 | 9.37 | 998 | 177474 | 437704 | 49988948 |
Product dose omission issue | 111.42 | 9.37 | 308 | 178164 | 183530 | 50243122 |
Intestinal pseudo-obstruction | 111.26 | 9.37 | 54 | 178418 | 700 | 50425952 |
Drug ineffective | 110.36 | 9.37 | 2134 | 176338 | 817199 | 49609453 |
Fatigue | 106.52 | 9.37 | 1807 | 176665 | 705794 | 49720858 |
Helicobacter infection | 105.64 | 9.37 | 23 | 178449 | 49679 | 50376973 |
Delirium | 105.03 | 9.37 | 335 | 178137 | 37857 | 50388795 |
Folliculitis | 104.79 | 9.37 | 9 | 178463 | 39216 | 50387436 |
Swelling | 103.72 | 9.37 | 362 | 178110 | 200510 | 50226142 |
Off label use | 103.67 | 9.37 | 1122 | 177350 | 473304 | 49953348 |
Muscle injury | 103.43 | 9.37 | 7 | 178465 | 37104 | 50389548 |
Malignant neoplasm progression | 101.81 | 9.37 | 493 | 177979 | 67631 | 50359021 |
Exposure via ingestion | 99.27 | 9.37 | 81 | 178391 | 2722 | 50423930 |
Mental status changes | 97.79 | 9.37 | 316 | 178156 | 35956 | 50390696 |
Contraindicated product administered | 97.55 | 9.37 | 240 | 178232 | 148718 | 50277934 |
Sleep disorder due to general medical condition, insomnia type | 97.11 | 9.37 | 3 | 178469 | 31444 | 50395208 |
Wound | 96.03 | 9.37 | 140 | 178332 | 105654 | 50320998 |
Poisoning | 93.64 | 9.37 | 162 | 178310 | 12267 | 50414385 |
Nasopharyngitis | 93.45 | 9.37 | 357 | 178115 | 192570 | 50234082 |
Duodenal ulcer perforation | 93.18 | 9.37 | 23 | 178449 | 45588 | 50381064 |
Hallucination | 88.86 | 9.37 | 363 | 178109 | 46294 | 50380358 |
Maternal exposure during pregnancy | 88.60 | 9.37 | 279 | 178193 | 159499 | 50267153 |
Device expulsion | 88.11 | 9.37 | 3 | 178469 | 28819 | 50397833 |
Asphyxia | 86.16 | 9.37 | 101 | 178371 | 5326 | 50421326 |
Drug screen positive | 85.70 | 9.37 | 81 | 178391 | 3321 | 50423331 |
Drug abuser | 84.29 | 9.37 | 74 | 178398 | 2754 | 50423898 |
Irritable bowel syndrome | 84.08 | 9.37 | 38 | 178434 | 51403 | 50375249 |
Balance disorder | 83.58 | 9.37 | 479 | 177993 | 70111 | 50356541 |
White blood cell count abnormal | 82.66 | 9.37 | 99 | 178373 | 5341 | 50421311 |
Acute chest syndrome | 82.01 | 9.37 | 42 | 178430 | 615 | 50426037 |
Maternal exposure during delivery | 80.59 | 9.37 | 48 | 178424 | 958 | 50425694 |
Drug diversion | 78.76 | 9.37 | 43 | 178429 | 722 | 50425930 |
Soft tissue disorder | 78.10 | 9.37 | 85 | 178387 | 4129 | 50422523 |
Injection site erythema | 77.42 | 9.37 | 90 | 178382 | 74846 | 50351806 |
Hepatic enzyme increased | 76.08 | 9.37 | 240 | 178232 | 137140 | 50289512 |
Infusion related reaction | 75.64 | 9.37 | 324 | 178148 | 169233 | 50257419 |
Weight increased | 74.88 | 9.37 | 412 | 178060 | 201479 | 50225173 |
Ill-defined disorder | 72.68 | 9.37 | 52 | 178420 | 54602 | 50372050 |
Intentional product misuse | 72.55 | 9.37 | 342 | 178130 | 46392 | 50380260 |
Injection site pain | 71.01 | 9.37 | 181 | 178291 | 110843 | 50315809 |
Apnoea | 70.65 | 9.37 | 104 | 178368 | 6862 | 50419790 |
Discomfort | 69.86 | 9.37 | 176 | 178296 | 108204 | 50318448 |
Respiratory failure | 69.07 | 9.37 | 554 | 177918 | 90627 | 50336025 |
Joint swelling | 65.80 | 9.37 | 551 | 177921 | 244735 | 50181917 |
Confusional state | 63.47 | 9.37 | 964 | 177508 | 184964 | 50241688 |
Injection site reaction | 63.45 | 9.37 | 50 | 178422 | 49982 | 50376670 |
Rheumatoid factor positive | 63.01 | 9.37 | 50 | 178422 | 49809 | 50376843 |
Gastrointestinal disorder | 62.74 | 9.37 | 151 | 178321 | 94305 | 50332347 |
Poisoning deliberate | 62.07 | 9.37 | 105 | 178367 | 7807 | 50418845 |
Abortion spontaneous | 62.05 | 9.37 | 35 | 178437 | 41737 | 50384915 |
Hypoxia | 60.56 | 9.37 | 347 | 178125 | 50776 | 50375876 |
Headache | 60.52 | 9.37 | 1344 | 177128 | 505191 | 49921461 |
Anterior spinal artery syndrome | 59.92 | 9.37 | 19 | 178453 | 67 | 50426585 |
Hypercapnia | 58.80 | 9.37 | 77 | 178395 | 4550 | 50422102 |
Product use issue | 58.76 | 9.37 | 299 | 178173 | 149176 | 50277476 |
Rash | 58.04 | 9.37 | 1141 | 177331 | 436330 | 49990322 |
Dilatation intrahepatic duct acquired | 57.54 | 9.37 | 33 | 178439 | 612 | 50426040 |
Macular degeneration | 55.93 | 9.37 | 143 | 178329 | 14245 | 50412407 |
Withdrawal syndrome | 54.61 | 9.37 | 161 | 178311 | 17429 | 50409223 |
Nausea | 53.67 | 9.37 | 3018 | 175454 | 702380 | 49724272 |
Impaired healing | 53.45 | 9.37 | 103 | 178369 | 69683 | 50356969 |
Injection site pruritus | 51.73 | 9.37 | 40 | 178432 | 40371 | 50386281 |
Therapeutic product effect decreased | 50.75 | 9.37 | 277 | 178195 | 135773 | 50290879 |
Respiratory acidosis | 49.96 | 9.37 | 82 | 178390 | 5946 | 50420706 |
Injection site swelling | 48.98 | 9.37 | 45 | 178427 | 41728 | 50384924 |
Blister | 48.84 | 9.37 | 147 | 178325 | 85271 | 50341381 |
Obliterative bronchiolitis | 48.37 | 9.37 | 45 | 178427 | 1808 | 50424844 |
Treatment failure | 48.23 | 9.37 | 286 | 178186 | 137351 | 50289301 |
Hypersensitivity | 47.55 | 9.37 | 507 | 177965 | 214654 | 50211998 |
Urinary retention | 46.91 | 9.37 | 200 | 178272 | 25990 | 50400662 |
Drug withdrawal syndrome neonatal | 46.69 | 9.37 | 44 | 178428 | 1797 | 50424855 |
Condition aggravated | 46.56 | 9.37 | 752 | 177720 | 296306 | 50130346 |
Aspiration | 45.67 | 9.37 | 101 | 178371 | 9163 | 50417489 |
Mobility decreased | 44.78 | 9.37 | 455 | 178017 | 79493 | 50347159 |
Acidosis | 44.35 | 9.37 | 106 | 178366 | 10121 | 50416531 |
Contusion | 43.17 | 9.37 | 226 | 178246 | 111957 | 50314695 |
Lethargy | 42.82 | 9.37 | 310 | 178162 | 49122 | 50377530 |
Synovitis | 42.02 | 9.37 | 260 | 178212 | 123605 | 50303047 |
Sphincter of Oddi dysfunction | 41.45 | 9.37 | 22 | 178450 | 348 | 50426304 |
Peripheral swelling | 40.52 | 9.37 | 498 | 177974 | 205438 | 50221214 |
Cough | 40.41 | 9.37 | 603 | 177869 | 240661 | 50185991 |
Cardiac failure congestive | 39.61 | 9.37 | 158 | 178314 | 84224 | 50342428 |
Plasma cell myeloma | 39.34 | 9.37 | 216 | 178256 | 31106 | 50395546 |
Accidental death | 39.19 | 9.37 | 39 | 178433 | 1705 | 50424947 |
Anaphylactic reaction | 39.06 | 9.37 | 325 | 178147 | 53730 | 50372922 |
Pregnancy | 38.20 | 9.37 | 29 | 178443 | 29548 | 50397104 |
Nasal congestion | 37.81 | 9.37 | 77 | 178395 | 51043 | 50375609 |
Pulseless electrical activity | 37.66 | 9.37 | 78 | 178394 | 6763 | 50419889 |
Iodine allergy | 37.65 | 9.37 | 26 | 178446 | 675 | 50425977 |
Agitation | 37.00 | 9.37 | 318 | 178154 | 53066 | 50373586 |
Gangrene | 36.45 | 9.37 | 62 | 178410 | 4630 | 50422022 |
Drug tolerance | 36.36 | 9.37 | 64 | 178408 | 4912 | 50421740 |
Visceral congestion | 36.23 | 9.37 | 19 | 178453 | 293 | 50426359 |
Neutropenic sepsis | 36.10 | 9.37 | 121 | 178351 | 14026 | 50412626 |
COVID-19 | 35.62 | 9.37 | 69 | 178403 | 46593 | 50380059 |
Sepsis | 34.67 | 9.37 | 660 | 177812 | 132265 | 50294387 |
Accidental exposure to product by child | 34.63 | 9.37 | 29 | 178443 | 1011 | 50425641 |
Diarrhoea | 34.62 | 9.37 | 1710 | 176762 | 586766 | 49839886 |
Narcotic bowel syndrome | 34.32 | 9.37 | 14 | 178458 | 116 | 50426536 |
Rheumatoid nodule | 33.80 | 9.37 | 3 | 178469 | 12732 | 50413920 |
Foetal megacystis | 33.79 | 9.37 | 10 | 178462 | 26 | 50426626 |
Pulmonary oedema | 33.65 | 9.37 | 291 | 178181 | 48647 | 50378005 |
Wrong technique in product usage process | 33.58 | 9.37 | 93 | 178379 | 55417 | 50371235 |
Sopor | 33.56 | 9.37 | 14 | 178458 | 19865 | 50406787 |
Dizziness | 33.43 | 9.37 | 948 | 177524 | 345421 | 50081231 |
Pneumonia viral | 33.12 | 9.37 | 74 | 178398 | 6760 | 50419892 |
Mucosal inflammation | 32.64 | 9.37 | 248 | 178224 | 39894 | 50386758 |
Post procedural complication | 32.38 | 9.37 | 122 | 178350 | 14982 | 50411670 |
Abdominal pain | 31.54 | 9.37 | 1072 | 177400 | 235156 | 50191496 |
Systemic mastocytosis | 31.52 | 9.37 | 14 | 178458 | 146 | 50426506 |
Drug resistance | 31.07 | 9.37 | 14 | 178458 | 18975 | 50407677 |
Pancreatic fibrosis | 30.91 | 9.37 | 12 | 178460 | 86 | 50426566 |
Brain oedema | 30.86 | 9.37 | 105 | 178367 | 12265 | 50414387 |
Tonsillar disorder | 30.70 | 9.37 | 27 | 178445 | 1007 | 50425645 |
Oxygen saturation decreased | 30.70 | 9.37 | 394 | 178078 | 72854 | 50353798 |
Hip arthroplasty | 29.88 | 9.37 | 38 | 178434 | 30391 | 50396261 |
Psoriatic arthropathy | 29.80 | 9.37 | 77 | 178395 | 46955 | 50379697 |
Cholestasis | 29.80 | 9.37 | 172 | 178300 | 25229 | 50401423 |
Asthma | 29.02 | 9.37 | 190 | 178282 | 89147 | 50337505 |
Disease progression | 28.88 | 9.37 | 487 | 177985 | 95379 | 50331273 |
Pruritus allergic | 28.85 | 9.37 | 27 | 178445 | 1093 | 50425559 |
Implant site extravasation | 28.82 | 9.37 | 19 | 178453 | 456 | 50426196 |
Cyanosis | 28.79 | 9.37 | 118 | 178354 | 15066 | 50411586 |
Sternal fracture | 28.09 | 9.37 | 35 | 178437 | 1967 | 50424685 |
Injection site rash | 27.95 | 9.37 | 11 | 178461 | 16166 | 50410486 |
Basal cell carcinoma | 27.57 | 9.37 | 25 | 178447 | 23331 | 50403321 |
Loss of personal independence in daily activities | 27.57 | 9.37 | 140 | 178332 | 69910 | 50356742 |
Encephalopathy | 27.25 | 9.37 | 208 | 178264 | 33503 | 50393149 |
Pulmonary congestion | 26.97 | 9.37 | 116 | 178356 | 15131 | 50411521 |
Intentional product use issue | 26.84 | 9.37 | 160 | 178312 | 76758 | 50349894 |
Skin candida | 26.79 | 9.37 | 28 | 178444 | 1298 | 50425354 |
Allodynia | 26.64 | 9.37 | 21 | 178451 | 671 | 50425981 |
Colitis microscopic | 26.59 | 9.37 | 66 | 178406 | 6454 | 50420198 |
Femur fracture | 26.39 | 9.37 | 58 | 178414 | 37406 | 50389246 |
Coronary artery disease | 26.31 | 9.37 | 40 | 178432 | 29686 | 50396966 |
No adverse event | 26.20 | 9.37 | 49 | 178423 | 33529 | 50393123 |
Swollen joint count increased | 25.89 | 9.37 | 10 | 178462 | 14863 | 50411789 |
Syncope | 25.09 | 9.37 | 237 | 178235 | 102765 | 50323887 |
C-reactive protein abnormal | 25.02 | 9.37 | 37 | 178435 | 27772 | 50398880 |
Retinitis | 24.91 | 9.37 | 32 | 178440 | 1855 | 50424797 |
Pupil fixed | 24.83 | 9.37 | 29 | 178443 | 1523 | 50425129 |
Myalgia | 24.66 | 9.37 | 300 | 178172 | 124019 | 50302633 |
Dyspnoea exertional | 24.63 | 9.37 | 95 | 178377 | 51138 | 50375514 |
Heavy menstrual bleeding | 24.58 | 9.37 | 12 | 178460 | 15525 | 50411127 |
Alveolitis | 24.51 | 9.37 | 37 | 178435 | 2497 | 50424155 |
Erythema | 24.46 | 9.37 | 366 | 178106 | 146048 | 50280604 |
Breast cancer metastatic | 24.14 | 9.37 | 86 | 178386 | 10278 | 50416374 |
Rhythm idioventricular | 24.10 | 9.37 | 12 | 178460 | 165 | 50426487 |
Vascular resistance systemic decreased | 23.90 | 9.37 | 10 | 178462 | 89 | 50426563 |
Hospitalisation | 23.87 | 9.37 | 141 | 178331 | 67796 | 50358856 |
Rheumatic fever | 23.83 | 9.37 | 15 | 178457 | 16852 | 50409800 |
Hypoxic-ischaemic encephalopathy | 23.78 | 9.37 | 46 | 178426 | 3796 | 50422856 |
Cardiac output decreased | 23.77 | 9.37 | 22 | 178450 | 878 | 50425774 |
Tendonitis | 23.40 | 9.37 | 15 | 178457 | 16690 | 50409962 |
Anaesthesia | 23.31 | 9.37 | 15 | 178457 | 345 | 50426307 |
Progressive multifocal leukoencephalopathy | 22.97 | 9.37 | 6 | 178466 | 11451 | 50415201 |
Respiratory distress | 22.93 | 9.37 | 185 | 178287 | 30304 | 50396348 |
Musculoskeletal stiffness | 22.92 | 9.37 | 317 | 178155 | 128164 | 50298488 |
Spinal epidural haemorrhage | 22.88 | 9.37 | 10 | 178462 | 100 | 50426552 |
Injection site bruising | 22.68 | 9.37 | 61 | 178411 | 36707 | 50389945 |
Muscle twitching | 22.55 | 9.37 | 111 | 178361 | 15320 | 50411332 |
Hypoventilation | 21.93 | 9.37 | 45 | 178427 | 3876 | 50422776 |
Bradycardia | 21.92 | 9.37 | 334 | 178138 | 64092 | 50362560 |
Pupillary reflex impaired | 21.91 | 9.37 | 30 | 178442 | 1851 | 50424801 |
Antinuclear antibody negative | 21.85 | 9.37 | 12 | 178460 | 204 | 50426448 |
Peripheral nerve injury | 21.80 | 9.37 | 15 | 178457 | 387 | 50426265 |
Transient ischaemic attack | 21.77 | 9.37 | 51 | 178421 | 32159 | 50394493 |
Knee arthroplasty | 21.72 | 9.37 | 60 | 178412 | 35786 | 50390866 |
Neuroendocrine tumour of the lung | 21.70 | 9.37 | 6 | 178466 | 11 | 50426641 |
Gallbladder cholesterolosis | 21.51 | 9.37 | 19 | 178453 | 713 | 50425939 |
Seronegative arthritis | 21.23 | 9.37 | 31 | 178441 | 2030 | 50424622 |
Implant site discharge | 21.21 | 9.37 | 10 | 178462 | 121 | 50426531 |
Metastases to bone | 21.21 | 9.37 | 122 | 178350 | 17873 | 50408779 |
Libido increased | 21.19 | 9.37 | 24 | 178448 | 1219 | 50425433 |
Metastases to eye | 21.14 | 9.37 | 10 | 178462 | 122 | 50426530 |
Therapy interrupted | 21.02 | 9.37 | 24 | 178448 | 20128 | 50406524 |
Excessive eye blinking | 20.97 | 9.37 | 21 | 178451 | 925 | 50425727 |
Catheter site granuloma | 20.92 | 9.37 | 5 | 178467 | 3 | 50426649 |
Calcium deficiency | 20.90 | 9.37 | 21 | 178451 | 929 | 50425723 |
Anaesthetic complication | 20.77 | 9.37 | 28 | 178444 | 1702 | 50424950 |
Urinary bladder rupture | 20.65 | 9.37 | 10 | 178462 | 129 | 50426523 |
Multiple sclerosis relapse | 20.44 | 9.37 | 80 | 178392 | 42884 | 50383768 |
Spinal cord injury | 20.32 | 9.37 | 18 | 178454 | 678 | 50425974 |
Small intestinal obstruction | 20.30 | 9.37 | 111 | 178361 | 15957 | 50410695 |
Serotonin syndrome | 20.27 | 9.37 | 153 | 178319 | 24560 | 50402092 |
Faecaloma | 20.13 | 9.37 | 63 | 178409 | 7045 | 50419607 |
Injection site warmth | 20.05 | 9.37 | 12 | 178460 | 13854 | 50412798 |
Arterial occlusive disease | 19.96 | 9.37 | 49 | 178423 | 4759 | 50421893 |
Nasal disorder | 19.95 | 9.37 | 32 | 178440 | 2276 | 50424376 |
Administration site abscess | 19.90 | 9.37 | 6 | 178466 | 17 | 50426635 |
Increased bronchial secretion | 19.86 | 9.37 | 26 | 178446 | 1536 | 50425116 |
Incoherent | 19.60 | 9.37 | 45 | 178427 | 4185 | 50422467 |
Intentional self-injury | 19.60 | 9.37 | 32 | 178440 | 23080 | 50403572 |
Administration site induration | 19.18 | 9.37 | 6 | 178466 | 20 | 50426632 |
Diffuse axonal injury | 19.14 | 9.37 | 8 | 178464 | 71 | 50426581 |
Patient uncooperative | 19.08 | 9.37 | 10 | 178462 | 154 | 50426498 |
Disorientation | 18.93 | 9.37 | 200 | 178272 | 35284 | 50391368 |
Spinal cord compression | 18.92 | 9.37 | 41 | 178431 | 3668 | 50422984 |
Interstitial lung disease | 18.87 | 9.37 | 110 | 178362 | 53066 | 50373586 |
Hallucination, tactile | 18.76 | 9.37 | 11 | 178461 | 213 | 50426439 |
Administration site discharge | 18.74 | 9.37 | 6 | 178466 | 22 | 50426630 |
Hallucination, visual | 18.62 | 9.37 | 111 | 178361 | 16471 | 50410181 |
Cerebrovascular accident | 18.58 | 9.37 | 229 | 178243 | 94451 | 50332201 |
Blood pH decreased | 18.49 | 9.37 | 32 | 178440 | 2423 | 50424229 |
Breast cancer | 18.46 | 9.37 | 83 | 178389 | 42807 | 50383845 |
Pain in extremity | 18.36 | 9.37 | 781 | 177691 | 272084 | 50154568 |
Foetal heart rate abnormal | 18.21 | 9.37 | 15 | 178457 | 511 | 50426141 |
Hyperhidrosis | 18.10 | 9.37 | 428 | 178044 | 88998 | 50337654 |
Toxicologic test abnormal | 17.96 | 9.37 | 16 | 178456 | 607 | 50426045 |
Joint effusion | 17.82 | 9.37 | 12 | 178460 | 13009 | 50413643 |
Soft tissue injury | 17.79 | 9.37 | 24 | 178448 | 1460 | 50425192 |
Complex regional pain syndrome | 17.73 | 9.37 | 28 | 178444 | 1965 | 50424687 |
Therapy cessation | 17.72 | 9.37 | 41 | 178431 | 25970 | 50400682 |
Hepatocellular injury | 17.68 | 9.37 | 154 | 178318 | 25793 | 50400859 |
Dependence | 17.60 | 9.37 | 27 | 178445 | 1848 | 50424804 |
Tissue infiltration | 17.55 | 9.37 | 15 | 178457 | 538 | 50426114 |
Toxic leukoencephalopathy | 17.53 | 9.37 | 16 | 178456 | 627 | 50426025 |
Weaning failure | 17.43 | 9.37 | 12 | 178460 | 310 | 50426342 |
Central nervous system injury | 17.38 | 9.37 | 9 | 178463 | 135 | 50426517 |
Suicide attempt | 17.32 | 9.37 | 109 | 178363 | 51623 | 50375029 |
Cancer pain | 17.28 | 9.37 | 32 | 178440 | 2555 | 50424097 |
Congenital pulmonary hypertension | 17.27 | 9.37 | 7 | 178465 | 57 | 50426595 |
Blood phosphorus decreased | 17.22 | 9.37 | 40 | 178432 | 3749 | 50422903 |
Basal ganglion degeneration | 17.05 | 9.37 | 13 | 178459 | 395 | 50426257 |
Product quality issue | 16.99 | 9.37 | 54 | 178418 | 30804 | 50395848 |
Coombs positive haemolytic anaemia | 16.87 | 9.37 | 12 | 178460 | 327 | 50426325 |
Foetal monitoring abnormal | 16.86 | 9.37 | 10 | 178462 | 198 | 50426454 |
Abnormal behaviour | 16.86 | 9.37 | 123 | 178349 | 19535 | 50407117 |
Posterior reversible encephalopathy syndrome | 16.81 | 9.37 | 100 | 178372 | 14828 | 50411824 |
Full blood count abnormal | 16.64 | 9.37 | 36 | 178436 | 23352 | 50403300 |
Throat irritation | 16.60 | 9.37 | 53 | 178419 | 30186 | 50396466 |
Peptic ulcer perforation | 16.54 | 9.37 | 9 | 178463 | 150 | 50426502 |
Administration site odour | 16.50 | 9.37 | 6 | 178466 | 35 | 50426617 |
White blood cell count decreased | 16.45 | 9.37 | 301 | 178171 | 116421 | 50310231 |
Theft | 16.20 | 9.37 | 7 | 178465 | 68 | 50426584 |
Breakthrough pain | 16.12 | 9.37 | 20 | 178452 | 1119 | 50425533 |
Thymus disorder | 16.01 | 9.37 | 10 | 178462 | 218 | 50426434 |
Respiratory rate increased | 16 | 9.37 | 81 | 178391 | 11304 | 50415348 |
Nervous system disorder | 15.97 | 9.37 | 105 | 178367 | 16118 | 50410534 |
Chronic kidney disease | 15.92 | 9.37 | 79 | 178393 | 39692 | 50386960 |
Pituitary apoplexy | 15.81 | 9.37 | 8 | 178464 | 114 | 50426538 |
Hostility | 15.81 | 9.37 | 25 | 178447 | 1757 | 50424895 |
Fluid retention | 15.80 | 9.37 | 109 | 178363 | 50540 | 50376112 |
Injection site urticaria | 15.75 | 9.37 | 12 | 178460 | 12205 | 50414447 |
Sinus tachycardia | 15.75 | 9.37 | 129 | 178343 | 21225 | 50405427 |
Infection | 15.73 | 9.37 | 477 | 177995 | 172477 | 50254175 |
Bronchitis | 15.51 | 9.37 | 266 | 178206 | 103893 | 50322759 |
Pulmonary embolism | 15.49 | 9.37 | 469 | 178003 | 101235 | 50325417 |
Tenosynovitis | 15.48 | 9.37 | 9 | 178463 | 10556 | 50416096 |
Tachycardia | 15.45 | 9.37 | 461 | 178011 | 99302 | 50327350 |
Parkinsonism | 15.31 | 9.37 | 6 | 178466 | 8841 | 50417811 |
Injection site discolouration | 15.29 | 9.37 | 3 | 178469 | 6971 | 50419681 |
Ear pain | 15.22 | 9.37 | 50 | 178422 | 28233 | 50398419 |
Herpes simplex reactivation | 15.18 | 9.37 | 12 | 178460 | 385 | 50426267 |
Palpitations | 15.17 | 9.37 | 238 | 178234 | 94268 | 50332384 |
Acute kidney injury | 15.15 | 9.37 | 965 | 177507 | 227093 | 50199559 |
Administration site haemorrhage | 15.12 | 9.37 | 7 | 178465 | 81 | 50426571 |
Abortion induced | 15.11 | 9.37 | 7 | 178465 | 9337 | 50417315 |
Cytomegalovirus infection | 15.11 | 9.37 | 25 | 178447 | 17937 | 50408715 |
Device difficult to use | 15.09 | 9.37 | 8 | 178464 | 9878 | 50416774 |
Myocardial infarction | 15.05 | 9.37 | 222 | 178250 | 88805 | 50337847 |
Epidural analgesia | 15 | 9.37 | 6 | 178466 | 47 | 50426605 |
Eye pain | 14.83 | 9.37 | 51 | 178421 | 28398 | 50398254 |
Hepatic function abnormal | 14.82 | 9.37 | 62 | 178410 | 32619 | 50394033 |
Retrograde amnesia | 14.81 | 9.37 | 12 | 178460 | 399 | 50426253 |
Suspected suicide | 14.73 | 9.37 | 47 | 178425 | 5310 | 50421342 |
Stomatitis | 14.71 | 9.37 | 260 | 178212 | 101084 | 50325568 |
Skin reaction | 14.67 | 9.37 | 80 | 178392 | 11488 | 50415164 |
Osteoarthritis | 14.59 | 9.37 | 163 | 178309 | 68443 | 50358209 |
Prescribed underdose | 14.56 | 9.37 | 21 | 178451 | 15928 | 50410724 |
PO2 decreased | 14.56 | 9.37 | 21 | 178451 | 1360 | 50425292 |
Post-traumatic neck syndrome | 14.52 | 9.37 | 25 | 178447 | 1885 | 50424767 |
Mydriasis | 14.51 | 9.37 | 75 | 178397 | 10552 | 50416100 |
Influenza like illness | 14.51 | 9.37 | 131 | 178341 | 57328 | 50369324 |
Type 2 diabetes mellitus | 14.51 | 9.37 | 67 | 178405 | 34308 | 50392344 |
Neuralgia | 14.50 | 9.37 | 129 | 178343 | 21734 | 50404918 |
Neuromuscular block prolonged | 14.49 | 9.37 | 13 | 178459 | 498 | 50426154 |
Keratitis | 14.47 | 9.37 | 29 | 178443 | 2456 | 50424196 |
Documented hypersensitivity to administered product | 14.45 | 9.37 | 13 | 178459 | 500 | 50426152 |
Injection site cyst | 14.38 | 9.37 | 6 | 178466 | 53 | 50426599 |
Withdrawal catatonia | 14.38 | 9.37 | 6 | 178466 | 53 | 50426599 |
Panniculitis | 14.34 | 9.37 | 6 | 178466 | 8497 | 50418155 |
Stroke volume increased | 14.24 | 9.37 | 4 | 178468 | 8 | 50426644 |
Genital haemorrhage | 14.05 | 9.37 | 3 | 178469 | 6571 | 50420081 |
Eye disorder | 14.05 | 9.37 | 28 | 178444 | 18711 | 50407941 |
Neoplasm progression | 14.02 | 9.37 | 161 | 178311 | 28996 | 50397656 |
Suspected product tampering | 13.95 | 9.37 | 3 | 178469 | 0 | 50426652 |
Agonal death struggle | 13.95 | 9.37 | 3 | 178469 | 0 | 50426652 |
Infusion site granuloma | 13.95 | 9.37 | 3 | 178469 | 0 | 50426652 |
Drug eruption | 13.94 | 9.37 | 40 | 178432 | 23566 | 50403086 |
Dehydration | 13.85 | 9.37 | 664 | 177808 | 151785 | 50274867 |
Skin cancer | 13.76 | 9.37 | 8 | 178464 | 9386 | 50417266 |
Heat stroke | 13.75 | 9.37 | 14 | 178458 | 629 | 50426023 |
Myelodysplastic syndrome | 13.74 | 9.37 | 20 | 178452 | 15112 | 50411540 |
Product name confusion | 13.64 | 9.37 | 6 | 178466 | 61 | 50426591 |
Paranasal cyst | 13.58 | 9.37 | 10 | 178462 | 288 | 50426364 |
Flushing | 13.56 | 9.37 | 161 | 178311 | 66854 | 50359798 |
Infusion | 13.55 | 9.37 | 8 | 178464 | 157 | 50426495 |
Metastasis | 13.54 | 9.37 | 40 | 178432 | 4335 | 50422317 |
Hypercreatininaemia | 13.47 | 9.37 | 11 | 178461 | 370 | 50426282 |
Livedo reticularis | 13.44 | 9.37 | 26 | 178446 | 2146 | 50424506 |
Vascular malformation | 13.43 | 9.37 | 10 | 178462 | 293 | 50426359 |
Impaired work ability | 13.43 | 9.37 | 17 | 178455 | 13623 | 50413029 |
Cardiac failure | 13.42 | 9.37 | 188 | 178284 | 75852 | 50350800 |
Spinal cord paralysis | 13.36 | 9.37 | 5 | 178467 | 32 | 50426620 |
Carcinoid tumour | 13.29 | 9.37 | 10 | 178462 | 298 | 50426354 |
Haemangioma of skin | 13.23 | 9.37 | 10 | 178462 | 300 | 50426352 |
Drug tolerance increased | 13.19 | 9.37 | 9 | 178463 | 229 | 50426423 |
Feeling jittery | 13.11 | 9.37 | 12 | 178460 | 11148 | 50415504 |
Occupational dermatitis | 13.10 | 9.37 | 5 | 178467 | 34 | 50426618 |
Nodule | 13.10 | 9.37 | 25 | 178447 | 16978 | 50409674 |
Blood glucose increased | 13.06 | 9.37 | 175 | 178297 | 71149 | 50355503 |
Metastases to spine | 12.99 | 9.37 | 30 | 178442 | 2801 | 50423851 |
Transplant rejection | 12.96 | 9.37 | 9 | 178463 | 9600 | 50417052 |
Implant site infection | 12.94 | 9.37 | 16 | 178456 | 892 | 50425760 |
Menstruation irregular | 12.79 | 9.37 | 3 | 178469 | 6159 | 50420493 |
Adverse event | 12.77 | 9.37 | 96 | 178376 | 43667 | 50382985 |
Clonus | 12.75 | 9.37 | 38 | 178434 | 4137 | 50422515 |
Epidural haemorrhage | 12.74 | 9.37 | 7 | 178465 | 119 | 50426533 |
Vaginal flatulence | 12.73 | 9.37 | 9 | 178463 | 243 | 50426409 |
Polyarthritis | 12.73 | 9.37 | 6 | 178466 | 7921 | 50418731 |
Myocardial fibrosis | 12.70 | 9.37 | 14 | 178458 | 690 | 50425962 |
Fear-related avoidance of activities | 12.69 | 9.37 | 7 | 178465 | 120 | 50426532 |
Liver disorder | 12.68 | 9.37 | 78 | 178394 | 37144 | 50389508 |
Product selection error | 12.63 | 9.37 | 6 | 178466 | 74 | 50426578 |
Sickle cell anaemia with crisis | 12.62 | 9.37 | 40 | 178432 | 4503 | 50422149 |
Medication error | 12.60 | 9.37 | 188 | 178284 | 35916 | 50390736 |
Gastrooesophageal reflux disease | 12.43 | 9.37 | 192 | 178280 | 76236 | 50350416 |
Uterine enlargement | 12.41 | 9.37 | 17 | 178455 | 1049 | 50425603 |
Suicidal ideation | 12.41 | 9.37 | 130 | 178342 | 55255 | 50371397 |
Splenic injury | 12.24 | 9.37 | 8 | 178464 | 189 | 50426463 |
Therapeutic response decreased | 12.22 | 9.37 | 107 | 178365 | 47124 | 50379528 |
Myoglobin urine | 12.22 | 9.37 | 4 | 178468 | 16 | 50426636 |
Uveitis | 12.19 | 9.37 | 9 | 178463 | 9301 | 50417351 |
Liver function test abnormal | 12.18 | 9.37 | 222 | 178250 | 44117 | 50382535 |
Hypoacusis | 12.18 | 9.37 | 35 | 178437 | 20612 | 50406040 |
Substance use | 12.16 | 9.37 | 10 | 178462 | 340 | 50426312 |
Dyspnoea | 12.13 | 9.37 | 1720 | 176752 | 545888 | 49880764 |
Pemphigoid | 12.02 | 9.37 | 3 | 178469 | 5904 | 50420748 |
Hip surgery | 12.01 | 9.37 | 28 | 178444 | 2630 | 50424022 |
Back pain | 11.99 | 9.37 | 916 | 177556 | 219114 | 50207538 |
Hypothermia | 11.97 | 9.37 | 78 | 178394 | 11938 | 50414714 |
Blood pressure diastolic increased | 11.93 | 9.37 | 55 | 178417 | 7388 | 50419264 |
Anaesthetic complication pulmonary | 11.90 | 9.37 | 5 | 178467 | 45 | 50426607 |
Hypertension | 11.90 | 9.37 | 616 | 177856 | 210587 | 50216065 |
Chronic idiopathic pain syndrome | 11.88 | 9.37 | 3 | 178469 | 3 | 50426649 |
Analgesic therapy | 11.88 | 9.37 | 3 | 178469 | 3 | 50426649 |
Exposure to toxic agent | 11.85 | 9.37 | 34 | 178438 | 3624 | 50423028 |
Cardiac output increased | 11.83 | 9.37 | 7 | 178465 | 138 | 50426514 |
Stridor | 11.80 | 9.37 | 31 | 178441 | 3138 | 50423514 |
Myopathy | 11.75 | 9.37 | 9 | 178463 | 9130 | 50417522 |
Intestinal strangulation | 11.65 | 9.37 | 6 | 178466 | 89 | 50426563 |
Denture wearer | 11.64 | 9.37 | 8 | 178464 | 206 | 50426446 |
Brain injury | 11.61 | 9.37 | 47 | 178425 | 5967 | 50420685 |
Cardiopulmonary failure | 11.56 | 9.37 | 32 | 178440 | 3341 | 50423311 |
Terminal state | 11.55 | 9.37 | 24 | 178448 | 2086 | 50424566 |
Abdominal hernia | 11.41 | 9.37 | 38 | 178434 | 4391 | 50422261 |
Postoperative ileus | 11.40 | 9.37 | 11 | 178461 | 463 | 50426189 |
Pleuritic pain | 11.29 | 9.37 | 49 | 178423 | 6417 | 50420235 |
Antinuclear antibody positive | 11.28 | 9.37 | 4 | 178468 | 6268 | 50420384 |
Schizophrenia | 11.27 | 9.37 | 6 | 178466 | 7391 | 50419261 |
Sinus congestion | 11.24 | 9.37 | 20 | 178452 | 13951 | 50412701 |
Blood pressure systolic decreased | 11.20 | 9.37 | 45 | 178427 | 5694 | 50420958 |
Myelosuppression | 11.20 | 9.37 | 19 | 178453 | 13498 | 50413154 |
Haematotoxicity | 11.18 | 9.37 | 7 | 178465 | 7888 | 50418764 |
Gastritis fungal | 11.14 | 9.37 | 6 | 178466 | 98 | 50426554 |
Intraventricular haemorrhage neonatal | 11.11 | 9.37 | 7 | 178465 | 155 | 50426497 |
Blood pressure diastolic abnormal | 11.07 | 9.37 | 10 | 178462 | 9351 | 50417301 |
Incubator therapy | 11.05 | 9.37 | 4 | 178468 | 23 | 50426629 |
Pathological fracture | 11.04 | 9.37 | 55 | 178417 | 7627 | 50419025 |
Gastrointestinal haemorrhage | 10.99 | 9.37 | 187 | 178285 | 73134 | 50353518 |
Therapeutic product effect prolonged | 10.99 | 9.37 | 9 | 178463 | 304 | 50426348 |
Ischaemic stroke | 10.98 | 9.37 | 25 | 178447 | 15923 | 50410729 |
Colitis | 10.97 | 9.37 | 194 | 178278 | 38335 | 50388317 |
Urinary tract obstruction | 10.90 | 9.37 | 21 | 178451 | 1727 | 50424925 |
Rhinitis | 10.90 | 9.37 | 8 | 178464 | 8293 | 50418359 |
Influenza | 10.78 | 9.37 | 237 | 178235 | 89301 | 50337351 |
Laryngectomy | 10.77 | 9.37 | 4 | 178468 | 25 | 50426627 |
Inappropriate schedule of product administration | 10.51 | 9.37 | 184 | 178288 | 71647 | 50355005 |
Metastases to oesophagus | 10.51 | 9.37 | 4 | 178468 | 27 | 50426625 |
Rash pruritic | 10.44 | 9.37 | 113 | 178359 | 47733 | 50378919 |
Pleural effusion | 10.43 | 9.37 | 368 | 178104 | 81086 | 50345566 |
Asthenia | 10.42 | 9.37 | 976 | 177496 | 318066 | 50108586 |
Bone marrow failure | 10.42 | 9.37 | 56 | 178416 | 27568 | 50399084 |
Thirst decreased | 10.41 | 9.37 | 8 | 178464 | 246 | 50426406 |
Sepsis neonatal | 10.38 | 9.37 | 10 | 178462 | 420 | 50426232 |
Delayed recovery from anaesthesia | 10.36 | 9.37 | 13 | 178459 | 736 | 50425916 |
Blood alkaline phosphatase increased | 10.35 | 9.37 | 188 | 178284 | 37338 | 50389314 |
Ileus | 10.34 | 9.37 | 81 | 178391 | 13148 | 50413504 |
Large intestine perforation | 10.31 | 9.37 | 53 | 178419 | 7441 | 50419211 |
Product storage error | 10.29 | 9.37 | 17 | 178455 | 12207 | 50414445 |
Aplastic anaemia | 10.27 | 9.37 | 54 | 178418 | 7649 | 50419003 |
Tooth hypoplasia | 10.22 | 9.37 | 5 | 178467 | 66 | 50426586 |
Non-small cell lung cancer | 10.20 | 9.37 | 28 | 178444 | 2909 | 50423743 |
Lung cancer metastatic | 10.18 | 9.37 | 24 | 178448 | 2271 | 50424381 |
Self-medication | 10.15 | 9.37 | 24 | 178448 | 2275 | 50424377 |
Spleen congestion | 10.15 | 9.37 | 6 | 178466 | 118 | 50426534 |
Monoplegia | 10.14 | 9.37 | 27 | 178445 | 2756 | 50423896 |
Night sweats | 10.11 | 9.37 | 73 | 178399 | 33501 | 50393151 |
Blood creatine phosphokinase MB increased | 10.10 | 9.37 | 16 | 178456 | 1126 | 50425526 |
Pocket erosion | 10.08 | 9.37 | 3 | 178469 | 8 | 50426644 |
Wound infection staphylococcal | 10.01 | 9.37 | 25 | 178447 | 2454 | 50424198 |
Granulocytopenia | 10 | 9.37 | 3 | 178469 | 5228 | 50421424 |
Hypokalaemia | 9.93 | 9.37 | 392 | 178080 | 87600 | 50339052 |
Malnutrition | 9.90 | 9.37 | 80 | 178392 | 13109 | 50413543 |
Injection site induration | 9.90 | 9.37 | 9 | 178463 | 8388 | 50418264 |
Hyperreflexia | 9.88 | 9.37 | 40 | 178432 | 5078 | 50421574 |
Intestinal perforation | 9.82 | 9.37 | 67 | 178405 | 10412 | 50416240 |
Sleep disorder due to a general medical condition | 9.81 | 9.37 | 7 | 178465 | 7364 | 50419288 |
Cor pulmonale | 9.79 | 9.37 | 21 | 178451 | 1866 | 50424786 |
Loss of consciousness | 9.79 | 9.37 | 456 | 178016 | 103897 | 50322755 |
Factitious disorder | 9.78 | 9.37 | 5 | 178467 | 73 | 50426579 |
Adiposis dolorosa | 9.75 | 9.37 | 8 | 178464 | 271 | 50426381 |
Aspergillus infection | 9.73 | 9.37 | 6 | 178466 | 6815 | 50419837 |
Injection site mass | 9.68 | 9.37 | 26 | 178446 | 15654 | 50410998 |
Meningitis chemical | 9.68 | 9.37 | 6 | 178466 | 129 | 50426523 |
Dysphonia | 9.67 | 9.37 | 89 | 178383 | 38803 | 50387849 |
Bone cancer | 9.64 | 9.37 | 16 | 178456 | 1171 | 50425481 |
Alkalosis | 9.60 | 9.37 | 8 | 178464 | 277 | 50426375 |
PO2 abnormal | 9.59 | 9.37 | 3 | 178469 | 10 | 50426642 |
Respiratory paralysis | 9.59 | 9.37 | 3 | 178469 | 10 | 50426642 |
Cerebrospinal fluid leakage | 9.58 | 9.37 | 14 | 178458 | 918 | 50425734 |
Troponin increased | 9.54 | 9.37 | 55 | 178417 | 8063 | 50418589 |
Pulmonary infarction | 9.49 | 9.37 | 24 | 178448 | 2374 | 50424278 |
Nerve block | 9.49 | 9.37 | 10 | 178462 | 468 | 50426184 |
Haemorrhage | 9.47 | 9.37 | 132 | 178340 | 53309 | 50373343 |
Intestinal obstruction | 9.45 | 9.37 | 138 | 178334 | 26245 | 50400407 |
Buttock injury | 9.43 | 9.37 | 7 | 178465 | 204 | 50426448 |
Hyperchloraemia | 9.43 | 9.37 | 12 | 178460 | 689 | 50425963 |
Atrial fibrillation | 9.39 | 9.37 | 280 | 178192 | 101465 | 50325187 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 1367.30 | 10.18 | 2581 | 125470 | 171080 | 29275396 |
Drug hypersensitivity | 1284.49 | 10.18 | 1530 | 126521 | 66876 | 29379600 |
Drug abuse | 1213.55 | 10.18 | 1607 | 126444 | 78276 | 29368200 |
Respiratory depression | 623.09 | 10.18 | 496 | 127555 | 13027 | 29433449 |
Overdose | 579.51 | 10.18 | 1149 | 126902 | 78670 | 29367806 |
Drug dependence | 468.35 | 10.18 | 514 | 127537 | 20467 | 29426009 |
Accidental overdose | 397.85 | 10.18 | 434 | 127617 | 17159 | 29429317 |
Substance abuse | 293.59 | 10.18 | 240 | 127811 | 6547 | 29439929 |
Miosis | 284.65 | 10.18 | 253 | 127798 | 7756 | 29438720 |
Death | 250.25 | 10.18 | 2415 | 125636 | 339669 | 29106807 |
Somnolence | 250.18 | 10.18 | 934 | 127117 | 93021 | 29353455 |
Respiratory arrest | 249.25 | 10.18 | 421 | 127630 | 25412 | 29421064 |
Drug withdrawal syndrome | 192.23 | 10.18 | 307 | 127744 | 17677 | 29428799 |
Unresponsive to stimuli | 191.97 | 10.18 | 370 | 127681 | 24756 | 29421720 |
Off label use | 168.58 | 10.18 | 701 | 127350 | 300099 | 29146377 |
Delirium | 158.38 | 10.18 | 451 | 127600 | 38946 | 29407530 |
Poisoning | 157.27 | 10.18 | 205 | 127846 | 9788 | 29436688 |
Sedation | 155.21 | 10.18 | 274 | 127777 | 17131 | 29429345 |
Hyperaesthesia | 150.71 | 10.18 | 123 | 127928 | 3346 | 29443130 |
Pulmonary oedema | 145.16 | 10.18 | 461 | 127590 | 42274 | 29404202 |
Coma | 143.66 | 10.18 | 436 | 127615 | 39014 | 29407462 |
Bradypnoea | 142.51 | 10.18 | 102 | 127949 | 2269 | 29444207 |
Confusional state | 140.91 | 10.18 | 992 | 127059 | 126885 | 29319591 |
Mental status changes | 139.57 | 10.18 | 399 | 127652 | 34528 | 29411948 |
Depressed level of consciousness | 132.37 | 10.18 | 406 | 127645 | 36536 | 29409940 |
Inadequate analgesia | 127.88 | 10.18 | 100 | 127951 | 2554 | 29443922 |
Accidental death | 127.03 | 10.18 | 91 | 127960 | 2027 | 29444449 |
Malignant neoplasm progression | 127.02 | 10.18 | 644 | 127407 | 73215 | 29373261 |
Constipation | 126.55 | 10.18 | 887 | 127164 | 113273 | 29333203 |
Cardio-respiratory arrest | 123.79 | 10.18 | 490 | 127561 | 50111 | 29396365 |
Intentional product misuse | 123.32 | 10.18 | 380 | 127671 | 34281 | 29412195 |
Drug screen positive | 119.28 | 10.18 | 112 | 127939 | 3689 | 29442787 |
Asphyxia | 107.90 | 10.18 | 124 | 127927 | 5191 | 29441285 |
Respiratory rate decreased | 106.30 | 10.18 | 79 | 127972 | 1866 | 29444610 |
Acute chest syndrome | 105.97 | 10.18 | 43 | 128008 | 278 | 29446198 |
Lethargy | 104.36 | 10.18 | 379 | 127672 | 37201 | 29409275 |
Cardiac arrest | 104.33 | 10.18 | 681 | 127370 | 84910 | 29361566 |
Completed suicide | 102.78 | 10.18 | 706 | 127345 | 89540 | 29356936 |
Withdrawal syndrome | 94.08 | 10.18 | 170 | 127881 | 10822 | 29435654 |
Drug abuser | 85.75 | 10.18 | 94 | 127957 | 3733 | 29442743 |
Brain oedema | 82.56 | 10.18 | 171 | 127880 | 12049 | 29434427 |
Apnoea | 79.13 | 10.18 | 114 | 127937 | 5988 | 29440488 |
Agitation | 78.99 | 10.18 | 434 | 127617 | 50870 | 29395606 |
Vomiting | 76.86 | 10.18 | 1318 | 126733 | 210942 | 29235534 |
Product dose omission issue | 76.46 | 10.18 | 192 | 127859 | 96191 | 29350285 |
Drug ineffective | 73.58 | 10.18 | 1119 | 126932 | 362051 | 29084425 |
Product use in unapproved indication | 67.40 | 10.18 | 175 | 127876 | 86700 | 29359776 |
Myocardial infarction | 66.61 | 10.18 | 249 | 127802 | 110047 | 29336429 |
Pulmonary congestion | 65.97 | 10.18 | 158 | 127893 | 12278 | 29434198 |
Myoclonus | 64.16 | 10.18 | 163 | 127888 | 13146 | 29433330 |
Exposure to toxic agent | 60.76 | 10.18 | 65 | 127986 | 2510 | 29443966 |
Cardiac failure congestive | 59.60 | 10.18 | 154 | 127897 | 76427 | 29370049 |
Sedation complication | 58.96 | 10.18 | 47 | 128004 | 1235 | 29445241 |
Myalgia | 57.48 | 10.18 | 149 | 127902 | 73870 | 29372606 |
Plasma cell myeloma | 57.13 | 10.18 | 314 | 127737 | 36801 | 29409675 |
Nausea | 56.29 | 10.18 | 1644 | 126407 | 287611 | 29158865 |
COVID-19 | 53.82 | 10.18 | 46 | 128005 | 35968 | 29410508 |
Cytomegalovirus infection | 53.33 | 10.18 | 17 | 128034 | 23198 | 29423278 |
Pain | 51.69 | 10.18 | 1035 | 127016 | 170397 | 29276079 |
Sphincter of Oddi dysfunction | 51.10 | 10.18 | 20 | 128031 | 116 | 29446360 |
Oxygen saturation decreased | 46.69 | 10.18 | 344 | 127707 | 44593 | 29401883 |
Cough | 46.14 | 10.18 | 340 | 127711 | 126387 | 29320089 |
Treatment failure | 45.21 | 10.18 | 56 | 127995 | 36883 | 29409593 |
Exposure via ingestion | 44.23 | 10.18 | 49 | 128002 | 1969 | 29444507 |
Hypoxia | 43.83 | 10.18 | 353 | 127698 | 47026 | 29399450 |
Hypogonadism male | 43.74 | 10.18 | 22 | 128029 | 248 | 29446228 |
Drug resistance | 42.49 | 10.18 | 20 | 128031 | 21520 | 29424956 |
Drug diversion | 42.09 | 10.18 | 32 | 128019 | 783 | 29445693 |
Cerebrovascular accident | 41.14 | 10.18 | 182 | 127869 | 76729 | 29369747 |
Pneumonia aspiration | 40.92 | 10.18 | 286 | 127765 | 36451 | 29410025 |
Dizziness | 40.82 | 10.18 | 577 | 127474 | 189107 | 29257369 |
Hypoxic-ischaemic encephalopathy | 40.20 | 10.18 | 69 | 127982 | 4215 | 29442261 |
Hallucination | 39.67 | 10.18 | 330 | 127721 | 44382 | 29402094 |
Renal impairment | 39.66 | 10.18 | 199 | 127852 | 81134 | 29365342 |
Syncope | 39.17 | 10.18 | 200 | 127851 | 81171 | 29365305 |
Drug use disorder | 38.74 | 10.18 | 60 | 127991 | 3362 | 29443114 |
Diarrhoea | 38.54 | 10.18 | 1122 | 126929 | 331576 | 29114900 |
Melaena | 38.43 | 10.18 | 47 | 128004 | 31129 | 29415347 |
Coronary artery disease | 38.23 | 10.18 | 84 | 127967 | 44106 | 29402370 |
Hyperhidrosis | 37.94 | 10.18 | 437 | 127614 | 64103 | 29382373 |
Opiates positive | 37.35 | 10.18 | 25 | 128026 | 497 | 29445979 |
Hospitalisation | 36.91 | 10.18 | 91 | 127960 | 45897 | 29400579 |
Hypoventilation | 36.72 | 10.18 | 53 | 127998 | 2788 | 29443688 |
Respiratory acidosis | 35.84 | 10.18 | 66 | 127985 | 4262 | 29442214 |
Respiratory distress | 35.79 | 10.18 | 250 | 127801 | 31856 | 29414620 |
Cancer pain | 33.63 | 10.18 | 46 | 128005 | 2301 | 29444175 |
Clumsiness | 32.03 | 10.18 | 36 | 128015 | 1470 | 29445006 |
Diaphragmatic spasm | 31.79 | 10.18 | 13 | 128038 | 86 | 29446390 |
Serotonin syndrome | 31.68 | 10.18 | 155 | 127896 | 17357 | 29429119 |
Basal cell carcinoma | 31.41 | 10.18 | 17 | 128034 | 16893 | 29429583 |
Stupor | 30.91 | 10.18 | 48 | 128003 | 2696 | 29443780 |
Blood pH decreased | 30.85 | 10.18 | 42 | 128009 | 2091 | 29444385 |
Urinary retention | 30.77 | 10.18 | 240 | 127811 | 31658 | 29414818 |
Faecal volume decreased | 29.91 | 10.18 | 13 | 128038 | 102 | 29446374 |
Diabetes mellitus inadequate control | 29.49 | 10.18 | 8 | 128043 | 12126 | 29434350 |
Neutropenia | 29.25 | 10.18 | 398 | 127653 | 131313 | 29315163 |
Drug tolerance | 29.06 | 10.18 | 41 | 128010 | 2112 | 29444364 |
Haematuria | 29.05 | 10.18 | 96 | 127955 | 44043 | 29402433 |
PCO2 increased | 28.87 | 10.18 | 22 | 128029 | 540 | 29445936 |
Metastases to bone | 28.45 | 10.18 | 101 | 127950 | 9797 | 29436679 |
Dyspnoea | 28.45 | 10.18 | 1142 | 126909 | 325590 | 29120886 |
Tubulointerstitial nephritis | 28.28 | 10.18 | 21 | 128030 | 17622 | 29428854 |
Leukopenia | 28.10 | 10.18 | 133 | 127918 | 55070 | 29391406 |
Blood glucose increased | 27.80 | 10.18 | 146 | 127905 | 58838 | 29387638 |
Aspiration | 27.67 | 10.18 | 102 | 127949 | 10078 | 29436398 |
Visual acuity reduced | 27.56 | 10.18 | 15 | 128036 | 14861 | 29431615 |
Cardiac failure | 27.28 | 10.18 | 216 | 127835 | 79071 | 29367405 |
Breakthrough pain | 27.16 | 10.18 | 21 | 128030 | 527 | 29445949 |
Atrial fibrillation | 26.91 | 10.18 | 310 | 127741 | 105336 | 29341140 |
Hepatic function abnormal | 26.80 | 10.18 | 84 | 127967 | 39175 | 29407301 |
Haematochezia | 26.78 | 10.18 | 77 | 127974 | 36906 | 29409570 |
Arthralgia | 25.82 | 10.18 | 437 | 127614 | 139180 | 29307296 |
Toxicologic test abnormal | 25.50 | 10.18 | 20 | 128031 | 513 | 29445963 |
Drug eruption | 25.48 | 10.18 | 21 | 128030 | 16720 | 29429756 |
Hypertension | 25.30 | 10.18 | 354 | 127697 | 116260 | 29330216 |
Foetal exposure during pregnancy | 24.90 | 10.18 | 70 | 127981 | 33797 | 29412679 |
Headache | 24.81 | 10.18 | 569 | 127482 | 173438 | 29273038 |
Pathogen resistance | 24.76 | 10.18 | 3 | 128048 | 8113 | 29438363 |
Postoperative ileus | 24.30 | 10.18 | 21 | 128030 | 619 | 29445857 |
Sinus tachycardia | 24.20 | 10.18 | 129 | 127922 | 14940 | 29431536 |
Chronic kidney disease | 24.10 | 10.18 | 79 | 127972 | 36337 | 29410139 |
Lung cancer metastatic | 23.98 | 10.18 | 40 | 128011 | 2387 | 29444089 |
Herpes simplex viraemia | 23.86 | 10.18 | 10 | 128041 | 71 | 29446405 |
Pulmonary haemorrhage | 23.64 | 10.18 | 91 | 127960 | 9179 | 29437297 |
Self-medication | 23.32 | 10.18 | 37 | 128014 | 2117 | 29444359 |
Glycosylated haemoglobin increased | 23.31 | 10.18 | 6 | 128045 | 9420 | 29437056 |
Fatigue | 23.11 | 10.18 | 1129 | 126922 | 315692 | 29130784 |
Spinal cord compression | 22.88 | 10.18 | 49 | 128002 | 3533 | 29442943 |
Interstitial lung disease | 22.87 | 10.18 | 151 | 127900 | 57567 | 29388909 |
Anaemia | 22.85 | 10.18 | 679 | 127372 | 200272 | 29246204 |
Eosinophilia | 22.77 | 10.18 | 38 | 128013 | 22123 | 29424353 |
Weight increased | 22.76 | 10.18 | 217 | 127834 | 76450 | 29370026 |
Neuroleptic malignant syndrome | 22.49 | 10.18 | 22 | 128029 | 16126 | 29430350 |
Poisoning deliberate | 22.41 | 10.18 | 65 | 127986 | 5666 | 29440810 |
Sinusitis | 22.40 | 10.18 | 75 | 127976 | 34275 | 29412201 |
Drug level | 22.23 | 10.18 | 5 | 128046 | 0 | 29446476 |
Reaction to excipient | 21.98 | 10.18 | 17 | 128034 | 427 | 29446049 |
Mydriasis | 21.89 | 10.18 | 67 | 127984 | 6018 | 29440458 |
Failure to suspend medication | 21.60 | 10.18 | 16 | 128035 | 376 | 29446100 |
Hypercapnia | 21.57 | 10.18 | 49 | 128002 | 3677 | 29442799 |
Intestinal obstruction | 21.41 | 10.18 | 150 | 127901 | 19127 | 29427349 |
Therapy interrupted | 21.40 | 10.18 | 5 | 128046 | 8381 | 29438095 |
Gout | 21.37 | 10.18 | 25 | 128026 | 16886 | 29429590 |
Condition aggravated | 20.95 | 10.18 | 478 | 127573 | 145817 | 29300659 |
Disease progression | 20.90 | 10.18 | 483 | 127568 | 81433 | 29365043 |
Medication error | 20.68 | 10.18 | 160 | 127891 | 21051 | 29425425 |
Accidental poisoning | 20.57 | 10.18 | 18 | 128033 | 540 | 29445936 |
Orthostatic hypotension | 20.41 | 10.18 | 42 | 128009 | 22587 | 29423889 |
Angina unstable | 20.06 | 10.18 | 11 | 128040 | 10854 | 29435622 |
Injection site swelling | 19.75 | 10.18 | 8 | 128043 | 9409 | 29437067 |
Post procedural complication | 19.54 | 10.18 | 93 | 127958 | 10296 | 29436180 |
Neurological examination abnormal | 19.53 | 10.18 | 13 | 128038 | 256 | 29446220 |
Abdominal compartment syndrome | 19.48 | 10.18 | 21 | 128030 | 818 | 29445658 |
Neuropathy peripheral | 19.43 | 10.18 | 205 | 127846 | 70822 | 29375654 |
Sickle cell anaemia with crisis | 19.41 | 10.18 | 38 | 128013 | 2570 | 29443906 |
Bladder dilatation | 19.29 | 10.18 | 26 | 128025 | 1282 | 29445194 |
Bone marrow failure | 19.25 | 10.18 | 58 | 127993 | 27391 | 29419085 |
Loss of personal independence in daily activities | 19.13 | 10.18 | 52 | 127999 | 25388 | 29421088 |
Weaning failure | 19.11 | 10.18 | 12 | 128039 | 213 | 29446263 |
Neoplasm progression | 19.04 | 10.18 | 142 | 127909 | 18470 | 29428006 |
Transplant rejection | 19.04 | 10.18 | 8 | 128043 | 9204 | 29437272 |
Nerve injury | 18.96 | 10.18 | 41 | 128010 | 2976 | 29443500 |
Progressive multifocal leukoencephalopathy | 18.96 | 10.18 | 7 | 128044 | 8712 | 29437764 |
Cerebrospinal fluid leakage | 18.89 | 10.18 | 15 | 128036 | 392 | 29446084 |
Drug-induced liver injury | 18.86 | 10.18 | 41 | 128010 | 21614 | 29424862 |
Secondary hypogonadism | 18.80 | 10.18 | 13 | 128038 | 273 | 29446203 |
Disorientation | 18.76 | 10.18 | 203 | 127848 | 29312 | 29417164 |
Hypopnoea | 18.61 | 10.18 | 25 | 128026 | 1229 | 29445247 |
Muscle swelling | 18.57 | 10.18 | 14 | 128037 | 338 | 29446138 |
Dyspnoea exertional | 18.51 | 10.18 | 88 | 127963 | 36402 | 29410074 |
Non-small cell lung cancer | 18.15 | 10.18 | 40 | 128011 | 2941 | 29443535 |
Full blood count abnormal | 18.11 | 10.18 | 23 | 128028 | 14990 | 29431486 |
Hepatic enzyme increased | 18.05 | 10.18 | 80 | 127971 | 33719 | 29412757 |
Tumour pain | 17.97 | 10.18 | 21 | 128030 | 895 | 29445581 |
C-reactive protein increased | 17.94 | 10.18 | 115 | 127936 | 44148 | 29402328 |
Rash | 17.88 | 10.18 | 657 | 127394 | 189162 | 29257314 |
Apnoeic attack | 17.79 | 10.18 | 13 | 128038 | 299 | 29446177 |
Patient uncooperative | 17.75 | 10.18 | 14 | 128037 | 362 | 29446114 |
Myopathy | 17.59 | 10.18 | 12 | 128039 | 10521 | 29435955 |
Acute myocardial infarction | 17.58 | 10.18 | 130 | 127921 | 48308 | 29398168 |
Hypoglycaemia | 17.42 | 10.18 | 130 | 127921 | 48216 | 29398260 |
Vein collapse | 17.42 | 10.18 | 7 | 128044 | 44 | 29446432 |
Glomerular filtration rate decreased | 17.31 | 10.18 | 14 | 128037 | 11252 | 29435224 |
White blood cell count decreased | 17.04 | 10.18 | 256 | 127795 | 83106 | 29363370 |
Device failure | 17.02 | 10.18 | 31 | 128020 | 1985 | 29444491 |
Pupil fixed | 16.82 | 10.18 | 28 | 128023 | 1668 | 29444808 |
Encephalopathy | 16.82 | 10.18 | 207 | 127844 | 30836 | 29415640 |
Psychotic behaviour | 16.74 | 10.18 | 17 | 128034 | 617 | 29445859 |
Cluster headache | 16.57 | 10.18 | 15 | 128036 | 471 | 29446005 |
Biliary obstruction | 16.56 | 10.18 | 34 | 128017 | 2380 | 29444096 |
Aggression | 16.34 | 10.18 | 230 | 127821 | 35311 | 29411165 |
Hypotension | 16.32 | 10.18 | 1012 | 127039 | 193342 | 29253134 |
Post laminectomy syndrome | 16.30 | 10.18 | 10 | 128041 | 170 | 29446306 |
Carcinoid crisis | 16.12 | 10.18 | 11 | 128040 | 226 | 29446250 |
Substance dependence | 16.07 | 10.18 | 13 | 128038 | 349 | 29446127 |
Salivary hypersecretion | 16.02 | 10.18 | 6 | 128045 | 7403 | 29439073 |
Cerebral infarction | 16.00 | 10.18 | 54 | 127997 | 24621 | 29421855 |
Visceral congestion | 16.00 | 10.18 | 15 | 128036 | 493 | 29445983 |
Dependence | 15.92 | 10.18 | 21 | 128030 | 1014 | 29445462 |
Fall | 15.85 | 10.18 | 617 | 127434 | 176561 | 29269915 |
Transient ischaemic attack | 15.73 | 10.18 | 50 | 128001 | 23220 | 29423256 |
Prescribed underdose | 15.71 | 10.18 | 7 | 128044 | 7779 | 29438697 |
Accidental exposure to product by child | 15.69 | 10.18 | 24 | 128027 | 1330 | 29445146 |
Vestibular disorder | 15.62 | 10.18 | 21 | 128030 | 1033 | 29445443 |
Incoherent | 15.61 | 10.18 | 46 | 128005 | 4046 | 29442430 |
Angina pectoris | 15.43 | 10.18 | 65 | 127986 | 27785 | 29418691 |
Diabetes mellitus | 15.38 | 10.18 | 105 | 127946 | 39726 | 29406750 |
Wrong technique in product usage process | 15.25 | 10.18 | 77 | 127974 | 31351 | 29415125 |
Cyanosis | 15.16 | 10.18 | 92 | 127959 | 11175 | 29435301 |
Drug reaction with eosinophilia and systemic symptoms | 15.10 | 10.18 | 66 | 127985 | 27926 | 29418550 |
Muscle spasticity | 15.05 | 10.18 | 51 | 128000 | 4832 | 29441644 |
Synovitis | 14.98 | 10.18 | 15 | 128036 | 10875 | 29435601 |
Ischaemic stroke | 14.97 | 10.18 | 29 | 128022 | 15948 | 29430528 |
Decerebration | 14.90 | 10.18 | 5 | 128046 | 17 | 29446459 |
Photosensitivity reaction | 14.86 | 10.18 | 11 | 128040 | 9247 | 29437229 |
Disease recurrence | 14.81 | 10.18 | 29 | 128022 | 15885 | 29430591 |
Liver disorder | 14.62 | 10.18 | 66 | 127985 | 27683 | 29418793 |
Hepatitis B | 14.59 | 10.18 | 3 | 128048 | 5494 | 29440982 |
Infusion site granuloma | 14.56 | 10.18 | 4 | 128047 | 5 | 29446471 |
Psoriasis | 14.50 | 10.18 | 81 | 127970 | 32146 | 29414330 |
Hypertensive crisis | 14.41 | 10.18 | 8 | 128043 | 7840 | 29438636 |
Liver function test | 14.39 | 10.18 | 6 | 128045 | 42 | 29446434 |
Peripheral swelling | 14.34 | 10.18 | 192 | 127859 | 63547 | 29382929 |
Eosinophil count increased | 14.29 | 10.18 | 7 | 128044 | 7362 | 29439114 |
Immune reconstitution inflammatory syndrome | 14.26 | 10.18 | 8 | 128043 | 7794 | 29438682 |
Intensive care | 14.02 | 10.18 | 12 | 128039 | 349 | 29446127 |
Blood cholesterol increased | 14.02 | 10.18 | 29 | 128022 | 15566 | 29430910 |
Monocytopenia | 13.99 | 10.18 | 7 | 128044 | 78 | 29446398 |
Victim of homicide | 13.97 | 10.18 | 8 | 128043 | 119 | 29446357 |
Postmortem blood drug level abnormal | 13.96 | 10.18 | 11 | 128040 | 284 | 29446192 |
Drug intolerance | 13.90 | 10.18 | 138 | 127913 | 48241 | 29398235 |
Therapy cessation | 13.77 | 10.18 | 26 | 128025 | 14436 | 29432040 |
Intentional misuse of drug delivery system | 13.77 | 10.18 | 4 | 128047 | 7 | 29446469 |
Injection site reaction | 13.64 | 10.18 | 17 | 128034 | 11171 | 29435305 |
Allodynia | 13.63 | 10.18 | 15 | 128036 | 598 | 29445878 |
Small intestinal obstruction | 13.56 | 10.18 | 100 | 127951 | 12961 | 29433515 |
Diabetic ketoacidosis | 13.53 | 10.18 | 31 | 128020 | 16042 | 29430434 |
Eosinophilic myocarditis | 13.50 | 10.18 | 13 | 128038 | 442 | 29446034 |
Neutrophil count decreased | 13.49 | 10.18 | 122 | 127929 | 43445 | 29403031 |
Medical device site bruise | 13.43 | 10.18 | 4 | 128047 | 8 | 29446468 |
Back pain | 13.41 | 10.18 | 556 | 127495 | 101728 | 29344748 |
Medical device site haemorrhage | 13.41 | 10.18 | 8 | 128043 | 129 | 29446347 |
Opiates | 13.34 | 10.18 | 3 | 128048 | 0 | 29446476 |
Arrhythmia neonatal | 13.34 | 10.18 | 3 | 128048 | 0 | 29446476 |
Electrocardiogram low voltage | 13.22 | 10.18 | 5 | 128046 | 26 | 29446450 |
Blood triglycerides increased | 13.19 | 10.18 | 22 | 128029 | 12812 | 29433664 |
Squamous cell carcinoma of skin | 13.12 | 10.18 | 13 | 128038 | 9473 | 29437003 |
Therapeutic product effect incomplete | 13.09 | 10.18 | 108 | 127943 | 39197 | 29407279 |
Tooth injury | 13.01 | 10.18 | 17 | 128034 | 813 | 29445663 |
C-reactive protein abnormal | 13.00 | 10.18 | 6 | 128045 | 6530 | 29439946 |
Acute pulmonary oedema | 12.98 | 10.18 | 61 | 127990 | 6718 | 29439758 |
Infusion site urticaria | 12.91 | 10.18 | 7 | 128044 | 93 | 29446383 |
Blood pH increased | 12.86 | 10.18 | 15 | 128036 | 638 | 29445838 |
Blood chromogranin A increased | 12.82 | 10.18 | 9 | 128042 | 194 | 29446282 |
Platelet count decreased | 12.80 | 10.18 | 350 | 127701 | 104322 | 29342154 |
Depression | 12.80 | 10.18 | 276 | 127775 | 84871 | 29361605 |
Herpes zoster | 12.73 | 10.18 | 77 | 127974 | 29975 | 29416501 |
Megacolon | 12.70 | 10.18 | 24 | 128027 | 1581 | 29444895 |
Acute respiratory failure | 12.60 | 10.18 | 172 | 127879 | 26230 | 29420246 |
Myelosuppression | 12.53 | 10.18 | 21 | 128030 | 12206 | 29434270 |
Arachnoiditis | 12.46 | 10.18 | 11 | 128040 | 334 | 29446142 |
End stage renal disease | 12.44 | 10.18 | 9 | 128042 | 7655 | 29438821 |
Hypercholesterolaemia | 12.42 | 10.18 | 8 | 128043 | 7230 | 29439246 |
Hypogammaglobulinaemia | 12.42 | 10.18 | 5 | 128046 | 5902 | 29440574 |
Carcinoid tumour | 12.35 | 10.18 | 9 | 128042 | 206 | 29446270 |
Pupillary reflex impaired | 12.32 | 10.18 | 22 | 128029 | 1387 | 29445089 |
Swelling of eyelid | 12.29 | 10.18 | 14 | 128037 | 580 | 29445896 |
Nephrotic syndrome | 12.29 | 10.18 | 6 | 128045 | 6322 | 29440154 |
Multiple sclerosis relapse | 12.28 | 10.18 | 19 | 128032 | 11400 | 29435076 |
Haemorrhagic stroke | 12.24 | 10.18 | 5 | 128046 | 5851 | 29440625 |
Product residue present | 12.13 | 10.18 | 31 | 128020 | 2508 | 29443968 |
Metastatic renal cell carcinoma | 12.13 | 10.18 | 26 | 128025 | 1876 | 29444600 |
Proteinuria | 12.11 | 10.18 | 32 | 128019 | 15772 | 29430704 |
Lactic acidosis | 12.04 | 10.18 | 79 | 127972 | 30168 | 29416308 |
Gastrointestinal hypomotility | 12.04 | 10.18 | 17 | 128034 | 876 | 29445600 |
Head injury | 11.99 | 10.18 | 33 | 128018 | 16048 | 29430428 |
Thrombotic microangiopathy | 11.89 | 10.18 | 12 | 128039 | 8669 | 29437807 |
Dysarthria | 11.87 | 10.18 | 194 | 127857 | 30717 | 29415759 |
Foaming at mouth | 11.80 | 10.18 | 15 | 128036 | 698 | 29445778 |
Disability | 11.79 | 10.18 | 44 | 128007 | 4372 | 29442104 |
Ejection fraction decreased | 11.76 | 10.18 | 33 | 128018 | 15945 | 29430531 |
Haemophagocytic lymphohistiocytosis | 11.75 | 10.18 | 17 | 128034 | 10487 | 29435989 |
Injection site erythema | 11.68 | 10.18 | 27 | 128024 | 13929 | 29432547 |
Erythema | 11.68 | 10.18 | 244 | 127807 | 75362 | 29371114 |
Cor pulmonale acute | 11.67 | 10.18 | 9 | 128042 | 225 | 29446251 |
Anamnestic reaction | 11.64 | 10.18 | 5 | 128046 | 38 | 29446438 |
Visual impairment | 11.62 | 10.18 | 78 | 127973 | 29630 | 29416846 |
Parathyroid hormone-related protein abnormal | 11.62 | 10.18 | 4 | 128047 | 15 | 29446461 |
Exposure during pregnancy | 11.52 | 10.18 | 12 | 128039 | 8542 | 29437934 |
Medical device site infection | 11.50 | 10.18 | 9 | 128042 | 230 | 29446246 |
Hyponatraemia | 11.43 | 10.18 | 215 | 127836 | 67418 | 29379058 |
Antasthmatic drug level | 11.42 | 10.18 | 5 | 128046 | 40 | 29446436 |
Analgesic drug level | 11.42 | 10.18 | 5 | 128046 | 40 | 29446436 |
Sitting disability | 11.41 | 10.18 | 7 | 128044 | 119 | 29446357 |
Venoocclusive liver disease | 11.39 | 10.18 | 8 | 128043 | 6909 | 29439567 |
Hypersensitivity | 11.31 | 10.18 | 161 | 127890 | 52742 | 29393734 |
Cardiac failure chronic | 11.30 | 10.18 | 7 | 128044 | 6460 | 29440016 |
Restlessness | 11.28 | 10.18 | 146 | 127905 | 21999 | 29424477 |
Infantile fibromatosis | 11.27 | 10.18 | 3 | 128048 | 3 | 29446473 |
Prostate cancer metastatic | 11.26 | 10.18 | 47 | 128004 | 4919 | 29441557 |
Accidental underdose | 11.23 | 10.18 | 11 | 128040 | 382 | 29446094 |
Intervertebral disc injury | 11.23 | 10.18 | 4 | 128047 | 17 | 29446459 |
Blood pressure diastolic decreased | 11.19 | 10.18 | 60 | 127991 | 6962 | 29439514 |
Obsessive-compulsive disorder | 11.15 | 10.18 | 3 | 128048 | 4573 | 29441903 |
Paraparesis | 11.12 | 10.18 | 24 | 128027 | 1740 | 29444736 |
Metastases to lung | 11.12 | 10.18 | 65 | 127986 | 7790 | 29438686 |
Cheyne-Stokes respiration | 11.11 | 10.18 | 9 | 128042 | 242 | 29446234 |
Dose calculation error | 11.11 | 10.18 | 5 | 128046 | 43 | 29446433 |
Alcohol poisoning | 11.10 | 10.18 | 34 | 128017 | 3055 | 29443421 |
Drug detoxification | 11.10 | 10.18 | 8 | 128043 | 180 | 29446296 |
Myocardial fibrosis | 11.09 | 10.18 | 18 | 128033 | 1050 | 29445426 |
Infusion related reaction | 11.07 | 10.18 | 129 | 127922 | 43757 | 29402719 |
Respiration abnormal | 11.07 | 10.18 | 31 | 128020 | 2649 | 29443827 |
Bronchopulmonary aspergillosis | 11.06 | 10.18 | 23 | 128028 | 12321 | 29434155 |
Device computer issue | 11.05 | 10.18 | 4 | 128047 | 18 | 29446458 |
Device toxicity | 11.05 | 10.18 | 4 | 128047 | 18 | 29446458 |
Disease prodromal stage | 11.05 | 10.18 | 4 | 128047 | 18 | 29446458 |
Respiratory rate increased | 11.02 | 10.18 | 70 | 127981 | 8638 | 29437838 |
Atrial septal defect | 10.99 | 10.18 | 8 | 128043 | 6781 | 29439695 |
Tuberculosis | 10.98 | 10.18 | 9 | 128042 | 7187 | 29439289 |
Injection site bruising | 10.94 | 10.18 | 10 | 128041 | 7570 | 29438906 |
Balance disorder | 10.89 | 10.18 | 102 | 127949 | 36068 | 29410408 |
Injection site pain | 10.87 | 10.18 | 89 | 127962 | 32357 | 29414119 |
Brain injury | 10.85 | 10.18 | 50 | 128001 | 5462 | 29441014 |
Perineal pain | 10.71 | 10.18 | 15 | 128036 | 767 | 29445709 |
Scan gallium abnormal | 10.71 | 10.18 | 4 | 128047 | 20 | 29446456 |
Haematotoxicity | 10.70 | 10.18 | 8 | 128043 | 6691 | 29439785 |
Injection site pruritus | 10.69 | 10.18 | 6 | 128045 | 5843 | 29440633 |
Narcotic bowel syndrome | 10.69 | 10.18 | 7 | 128044 | 134 | 29446342 |
Performance status decreased | 10.69 | 10.18 | 38 | 128013 | 3689 | 29442787 |
Dyschezia | 10.68 | 10.18 | 19 | 128032 | 1194 | 29445282 |
Palpitations | 10.67 | 10.18 | 90 | 127961 | 32514 | 29413962 |
Cachexia | 10.64 | 10.18 | 55 | 127996 | 6294 | 29440182 |
Electroencephalogram abnormal | 10.63 | 10.18 | 28 | 128023 | 2307 | 29444169 |
Nasopharyngitis | 10.61 | 10.18 | 188 | 127863 | 59477 | 29386999 |
Acute graft versus host disease | 10.60 | 10.18 | 6 | 128045 | 5818 | 29440658 |
Cholestatic liver injury | 10.59 | 10.18 | 23 | 128028 | 1674 | 29444802 |
Neuralgia | 10.58 | 10.18 | 82 | 127969 | 10792 | 29435684 |
Pelvic pain | 10.58 | 10.18 | 26 | 128025 | 2053 | 29444423 |
Vision blurred | 10.56 | 10.18 | 117 | 127934 | 40059 | 29406417 |
Buttock injury | 10.55 | 10.18 | 5 | 128046 | 49 | 29446427 |
Conjunctival discolouration | 10.55 | 10.18 | 4 | 128047 | 21 | 29446455 |
Necrotising colitis | 10.48 | 10.18 | 17 | 128034 | 991 | 29445485 |
Bradyphrenia | 10.44 | 10.18 | 41 | 128010 | 4173 | 29442303 |
Kidney transplant rejection | 10.40 | 10.18 | 9 | 128042 | 6996 | 29439480 |
Brain death | 10.37 | 10.18 | 28 | 128023 | 2342 | 29444134 |
Bronchiectasis | 10.35 | 10.18 | 8 | 128043 | 6577 | 29439899 |
Agranulocytosis | 10.35 | 10.18 | 49 | 128002 | 20291 | 29426185 |
Hepatotoxicity | 10.33 | 10.18 | 41 | 128010 | 17826 | 29428650 |
Tachyphylaxis | 10.32 | 10.18 | 6 | 128045 | 92 | 29446384 |
Duodenal ulcer | 10.29 | 10.18 | 15 | 128036 | 9223 | 29437253 |
Incorrect route of product administration | 10.26 | 10.18 | 81 | 127970 | 10720 | 29435756 |
Device breakage | 10.26 | 10.18 | 23 | 128028 | 1711 | 29444765 |
Faeces discoloured | 10.26 | 10.18 | 27 | 128024 | 13324 | 29433152 |
Limb discomfort | 10.21 | 10.18 | 16 | 128035 | 9552 | 29436924 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 6086.08 | 9.64 | 5983 | 248691 | 231832 | 64012226 |
Drug abuse | 2227.67 | 9.64 | 2677 | 251997 | 129697 | 64114361 |
Toxicity to various agents | 1977.14 | 9.64 | 4396 | 250278 | 359117 | 63884941 |
Respiratory depression | 910.44 | 9.64 | 749 | 253925 | 22694 | 64221364 |
Overdose | 828.26 | 9.64 | 1898 | 252776 | 157668 | 64086390 |
Accidental overdose | 718.35 | 9.64 | 770 | 253904 | 32787 | 64211271 |
Death | 637.49 | 9.64 | 3656 | 251018 | 479049 | 63765009 |
Respiratory arrest | 602.94 | 9.64 | 886 | 253788 | 52099 | 64191959 |
Sedation | 563.50 | 9.64 | 755 | 253919 | 40707 | 64203351 |
Miosis | 502.80 | 9.64 | 418 | 254256 | 12848 | 64231210 |
Depressed level of consciousness | 447.99 | 9.64 | 992 | 253682 | 80444 | 64163614 |
Somnolence | 446.86 | 9.64 | 1788 | 252886 | 201857 | 64042201 |
Constipation | 411.08 | 9.64 | 1894 | 252780 | 227443 | 64016615 |
Drug dependence | 394.82 | 9.64 | 568 | 254106 | 32744 | 64211314 |
Substance abuse | 365.11 | 9.64 | 299 | 254375 | 8993 | 64235065 |
Sedation complication | 340.93 | 9.64 | 301 | 254373 | 10053 | 64234005 |
Cardio-respiratory arrest | 338.49 | 9.64 | 1004 | 253670 | 97389 | 64146669 |
Cardiac arrest | 314.24 | 9.64 | 1323 | 253351 | 152741 | 64091317 |
Unresponsive to stimuli | 310.57 | 9.64 | 643 | 254031 | 49750 | 64194308 |
Completed suicide | 304.93 | 9.64 | 1715 | 252959 | 222699 | 64021359 |
Bradypnoea | 295.72 | 9.64 | 208 | 254466 | 4951 | 64239107 |
Drug withdrawal syndrome | 288.45 | 9.64 | 475 | 254199 | 30816 | 64213242 |
Coma | 269.62 | 9.64 | 860 | 253814 | 86755 | 64157303 |
Hyperaesthesia | 259.94 | 9.64 | 255 | 254419 | 9759 | 64234299 |
Respiratory rate decreased | 250.32 | 9.64 | 178 | 254496 | 4313 | 64239745 |
Poisoning | 244.64 | 9.64 | 363 | 254311 | 21516 | 64222542 |
Off label use | 239.85 | 9.64 | 1491 | 253183 | 631315 | 63612743 |
Delirium | 225.59 | 9.64 | 693 | 253981 | 68501 | 64175557 |
Creatinine renal clearance decreased | 221.42 | 9.64 | 279 | 254395 | 14142 | 64229916 |
Intentional product misuse | 211.89 | 9.64 | 698 | 253976 | 71597 | 64172461 |
Mental status changes | 208.24 | 9.64 | 622 | 254052 | 60540 | 64183518 |
Drug screen positive | 199.59 | 9.64 | 172 | 254502 | 5557 | 64238501 |
Malignant neoplasm progression | 197.30 | 9.64 | 926 | 253748 | 111945 | 64132113 |
Vomiting | 191.58 | 9.64 | 3146 | 251528 | 547971 | 63696087 |
Confusional state | 178.96 | 9.64 | 1694 | 252980 | 259450 | 63984608 |
Acute chest syndrome | 177.56 | 9.64 | 82 | 254592 | 834 | 64243224 |
Blood calcium decreased | 171.62 | 9.64 | 338 | 254336 | 25216 | 64218842 |
Asphyxia | 167.85 | 9.64 | 198 | 254476 | 9368 | 64234690 |
Accidental death | 159.37 | 9.64 | 126 | 254548 | 3599 | 64240459 |
Pulmonary oedema | 158.97 | 9.64 | 674 | 254000 | 78000 | 64166058 |
Myoclonus | 155.30 | 9.64 | 321 | 254353 | 24797 | 64219261 |
Drug abuser | 150.93 | 9.64 | 148 | 254526 | 5660 | 64238398 |
Inadequate analgesia | 145.87 | 9.64 | 123 | 254551 | 3855 | 64240203 |
Product dose omission issue | 143.82 | 9.64 | 350 | 254324 | 194397 | 64049661 |
Drug ineffective | 137.07 | 9.64 | 2416 | 252258 | 837831 | 63406227 |
Exposure via ingestion | 136.97 | 9.64 | 130 | 254544 | 4772 | 64239286 |
Lethargy | 136.03 | 9.64 | 608 | 254066 | 71986 | 64172072 |
Arthropathy | 132.21 | 9.64 | 170 | 254504 | 120797 | 64123261 |
Systemic lupus erythematosus | 124.59 | 9.64 | 76 | 254598 | 77536 | 64166522 |
Alopecia | 121.36 | 9.64 | 299 | 254375 | 165391 | 64078667 |
Contrast media allergy | 119.65 | 9.64 | 85 | 254589 | 2056 | 64242002 |
Apnoea | 118.06 | 9.64 | 174 | 254500 | 10248 | 64233810 |
Arthralgia | 117.44 | 9.64 | 1148 | 253526 | 441112 | 63802946 |
Hypotension | 111.03 | 9.64 | 2116 | 252558 | 378858 | 63865200 |
Brain oedema | 107.03 | 9.64 | 256 | 254418 | 21819 | 64222239 |
Drug diversion | 102.70 | 9.64 | 61 | 254613 | 1075 | 64242983 |
Agitation | 102.24 | 9.64 | 648 | 254026 | 87719 | 64156339 |
Hallucination | 101.10 | 9.64 | 560 | 254114 | 72228 | 64171830 |
Pemphigus | 100.88 | 9.64 | 57 | 254617 | 60644 | 64183414 |
Sinusitis | 100.20 | 9.64 | 272 | 254402 | 145656 | 64098402 |
Cardiac failure congestive | 96.89 | 9.64 | 234 | 254440 | 130346 | 64113712 |
Abdominal discomfort | 95.42 | 9.64 | 383 | 254291 | 181939 | 64062119 |
Withdrawal syndrome | 93.67 | 9.64 | 253 | 254421 | 23239 | 64220819 |
Glossodynia | 93.61 | 9.64 | 71 | 254603 | 64625 | 64179433 |
Weight increased | 92.11 | 9.64 | 481 | 254193 | 212867 | 64031191 |
Sleep disorder due to general medical condition, insomnia type | 86.73 | 9.64 | 4 | 254670 | 26266 | 64217792 |
Headache | 86.44 | 9.64 | 1521 | 253153 | 527946 | 63716112 |
Hypoxia | 86.16 | 9.64 | 620 | 254054 | 87529 | 64156529 |
COVID-19 | 85.02 | 9.64 | 79 | 254595 | 65061 | 64178997 |
Helicobacter infection | 83.29 | 9.64 | 24 | 254650 | 38338 | 64205720 |
Cognitive disorder | 82.72 | 9.64 | 433 | 254241 | 54654 | 64189404 |
Fatigue | 80.82 | 9.64 | 2296 | 252378 | 746434 | 63497624 |
Hand deformity | 79.73 | 9.64 | 78 | 254596 | 62693 | 64181365 |
Nasopharyngitis | 79.16 | 9.64 | 452 | 254222 | 195621 | 64048437 |
Sphincter of Oddi dysfunction | 77.54 | 9.64 | 36 | 254638 | 371 | 64243687 |
Myalgia | 76.94 | 9.64 | 343 | 254331 | 158274 | 64085784 |
Respiratory acidosis | 76.90 | 9.64 | 139 | 254535 | 9716 | 64234342 |
Maternal exposure during delivery | 75.82 | 9.64 | 46 | 254628 | 844 | 64243214 |
Nausea | 74.03 | 9.64 | 3800 | 250874 | 782000 | 63462058 |
Hypersensitivity | 73.96 | 9.64 | 463 | 254211 | 195989 | 64048069 |
Pulmonary congestion | 73.93 | 9.64 | 235 | 254439 | 23645 | 64220413 |
Injection site erythema | 73.77 | 9.64 | 103 | 254571 | 70697 | 64173361 |
Anti-cyclic citrullinated peptide antibody positive | 73.50 | 9.64 | 53 | 254621 | 49509 | 64194549 |
Cough | 73.22 | 9.64 | 801 | 253873 | 301347 | 63942711 |
Hypercapnia | 72.51 | 9.64 | 118 | 254556 | 7576 | 64236482 |
Plasma cell myeloma | 71.84 | 9.64 | 366 | 254308 | 45709 | 64198349 |
Muscle injury | 70.95 | 9.64 | 10 | 254664 | 26427 | 64217631 |
Cytomegalovirus infection | 70.86 | 9.64 | 29 | 254645 | 37170 | 64206888 |
Hepatic enzyme increased | 70.50 | 9.64 | 269 | 254405 | 129674 | 64114384 |
Device expulsion | 70.49 | 9.64 | 3 | 254671 | 21133 | 64222925 |
Myocardial infarction | 69.24 | 9.64 | 378 | 254296 | 165443 | 64078615 |
Pericarditis | 69.17 | 9.64 | 87 | 254587 | 62429 | 64181629 |
Urinary retention | 68.62 | 9.64 | 379 | 254295 | 48822 | 64195236 |
Orthostatic hypotension | 67.86 | 9.64 | 364 | 254310 | 46374 | 64197684 |
Duodenal ulcer perforation | 67.59 | 9.64 | 26 | 254648 | 34599 | 64209459 |
Condition aggravated | 67.20 | 9.64 | 1050 | 253624 | 371376 | 63872682 |
Joint swelling | 66.74 | 9.64 | 537 | 254137 | 214845 | 64029213 |
Oxygen saturation decreased | 66.30 | 9.64 | 681 | 253993 | 106495 | 64137563 |
Dizziness | 65.03 | 9.64 | 1252 | 253422 | 428911 | 63815147 |
Exposure to toxic agent | 64.31 | 9.64 | 99 | 254575 | 6060 | 64237998 |
Drug resistance | 64.26 | 9.64 | 29 | 254645 | 35073 | 64208985 |
Intestinal pseudo-obstruction | 63.57 | 9.64 | 57 | 254617 | 1943 | 64242115 |
Folliculitis | 63.15 | 9.64 | 20 | 254654 | 30057 | 64214001 |
Poisoning deliberate | 63.02 | 9.64 | 154 | 254520 | 13304 | 64230754 |
Injection site reaction | 62.79 | 9.64 | 55 | 254619 | 46609 | 64197449 |
Peripheral swelling | 60.95 | 9.64 | 530 | 254144 | 208623 | 64035435 |
Irritable bowel syndrome | 60.79 | 9.64 | 36 | 254638 | 37333 | 64206725 |
Injection site swelling | 60.31 | 9.64 | 45 | 254629 | 41308 | 64202750 |
Injection site pain | 60.19 | 9.64 | 231 | 254443 | 111177 | 64132881 |
Injection site pruritus | 59.37 | 9.64 | 38 | 254636 | 37788 | 64206270 |
Aspiration | 58.65 | 9.64 | 173 | 254501 | 16712 | 64227346 |
Syncope | 58.55 | 9.64 | 373 | 254301 | 157262 | 64086796 |
Toxicologic test abnormal | 57.99 | 9.64 | 44 | 254630 | 1181 | 64242877 |
Gastrointestinal disorder | 56.59 | 9.64 | 174 | 254500 | 89535 | 64154523 |
Contraindicated product administered | 56.07 | 9.64 | 227 | 254447 | 107602 | 64136456 |
Acidosis | 54.98 | 9.64 | 175 | 254499 | 17620 | 64226438 |
Accidental exposure to product by child | 54.87 | 9.64 | 58 | 254616 | 2427 | 64241631 |
Anterior spinal artery syndrome | 54.45 | 9.64 | 19 | 254655 | 84 | 64243974 |
Hypogonadism male | 53.18 | 9.64 | 20 | 254654 | 114 | 64243944 |
Balance disorder | 51.29 | 9.64 | 532 | 254142 | 83394 | 64160664 |
Post procedural complication | 51.17 | 9.64 | 193 | 254481 | 21160 | 64222898 |
Hypoventilation | 51.11 | 9.64 | 88 | 254586 | 5918 | 64238140 |
Infusion related reaction | 50.96 | 9.64 | 410 | 254264 | 164057 | 64080001 |
Synovitis | 50.65 | 9.64 | 210 | 254464 | 98880 | 64145178 |
Basal cell carcinoma | 49.75 | 9.64 | 30 | 254644 | 30808 | 64213250 |
Respiratory failure | 49.48 | 9.64 | 903 | 253771 | 160280 | 64083778 |
Dilatation intrahepatic duct acquired | 49.39 | 9.64 | 32 | 254642 | 662 | 64243396 |
Diarrhoea | 49.20 | 9.64 | 2343 | 252331 | 720361 | 63523697 |
Visceral congestion | 49.12 | 9.64 | 34 | 254640 | 788 | 64243270 |
Loss of personal independence in daily activities | 49.00 | 9.64 | 136 | 254538 | 72318 | 64171740 |
Opiates positive | 48.68 | 9.64 | 35 | 254639 | 863 | 64243195 |
Hypoxic-ischaemic encephalopathy | 48.50 | 9.64 | 95 | 254579 | 7057 | 64237001 |
Coronary artery disease | 48.29 | 9.64 | 104 | 254570 | 60329 | 64183729 |
Ill-defined disorder | 46.98 | 9.64 | 63 | 254611 | 43989 | 64200069 |
Product use in unapproved indication | 46.92 | 9.64 | 458 | 254216 | 176160 | 64067898 |
Treatment failure | 46.73 | 9.64 | 270 | 254404 | 116546 | 64127512 |
Red blood cell sedimentation rate abnormal | 46.61 | 9.64 | 5 | 254669 | 16301 | 64227757 |
Respiratory distress | 45.99 | 9.64 | 359 | 254315 | 51972 | 64192086 |
Cerebrovascular accident | 45.90 | 9.64 | 336 | 254338 | 137247 | 64106811 |
Swelling | 45.77 | 9.64 | 408 | 254266 | 159810 | 64084248 |
Drug tolerance | 45.17 | 9.64 | 84 | 254590 | 6001 | 64238057 |
Musculoskeletal stiffness | 45.00 | 9.64 | 293 | 254381 | 122913 | 64121145 |
Blood pH decreased | 44.90 | 9.64 | 70 | 254604 | 4332 | 64239726 |
Contusion | 44.21 | 9.64 | 266 | 254408 | 113699 | 64130359 |
Abortion spontaneous | 44.14 | 9.64 | 22 | 254652 | 25121 | 64218937 |
Narcotic bowel syndrome | 43.88 | 9.64 | 21 | 254653 | 233 | 64243825 |
Sopor | 43.61 | 9.64 | 32 | 254642 | 29629 | 64214429 |
Hyperhidrosis | 43.43 | 9.64 | 714 | 253960 | 124206 | 64119852 |
Cyanosis | 43.33 | 9.64 | 188 | 254486 | 21967 | 64222091 |
Spinal cord compression | 42.68 | 9.64 | 79 | 254595 | 5624 | 64238434 |
Cancer pain | 42.46 | 9.64 | 67 | 254607 | 4190 | 64239868 |
Encephalopathy | 42.40 | 9.64 | 386 | 254288 | 58433 | 64185625 |
Therapeutic product effect decreased | 42.29 | 9.64 | 274 | 254400 | 115077 | 64128981 |
Nasal congestion | 41.83 | 9.64 | 110 | 254564 | 59548 | 64184510 |
Serotonin syndrome | 41.72 | 9.64 | 282 | 254392 | 39000 | 64205058 |
Wrong technique in product usage process | 41.71 | 9.64 | 125 | 254549 | 64849 | 64179209 |
Dyspnoea exertional | 41.70 | 9.64 | 150 | 254524 | 73580 | 64170478 |
Erythema | 40.59 | 9.64 | 508 | 254166 | 186562 | 64057496 |
Wound | 40.39 | 9.64 | 160 | 254514 | 76317 | 64167741 |
Dyspnoea | 40.02 | 9.64 | 2377 | 252297 | 716297 | 63527761 |
Rash | 39.49 | 9.64 | 1447 | 253227 | 457102 | 63786956 |
Neutropenia | 39.40 | 9.64 | 687 | 253987 | 238937 | 64005121 |
Hospitalisation | 38.67 | 9.64 | 159 | 254515 | 75048 | 64169010 |
Progressive multifocal leukoencephalopathy | 38.50 | 9.64 | 12 | 254662 | 18220 | 64225838 |
Lung cancer metastatic | 37.86 | 9.64 | 54 | 254620 | 3086 | 64240972 |
Transplant rejection | 37.56 | 9.64 | 11 | 254663 | 17390 | 64226668 |
Interstitial lung disease | 37.44 | 9.64 | 229 | 254445 | 97503 | 64146555 |
Rheumatoid factor positive | 37.22 | 9.64 | 50 | 254624 | 34888 | 64209170 |
Drug eruption | 37.21 | 9.64 | 53 | 254621 | 36083 | 64207975 |
Haematochezia | 36.89 | 9.64 | 136 | 254538 | 66237 | 64177821 |
C-reactive protein abnormal | 35.85 | 9.64 | 37 | 254637 | 29010 | 64215048 |
Pupillary reflex impaired | 35.81 | 9.64 | 52 | 254622 | 3021 | 64241037 |
Allodynia | 35.80 | 9.64 | 34 | 254640 | 1249 | 64242809 |
Self-medication | 35.62 | 9.64 | 61 | 254613 | 4084 | 64239974 |
Pregnancy | 35.52 | 9.64 | 19 | 254655 | 20846 | 64223212 |
Pupil fixed | 35.23 | 9.64 | 53 | 254621 | 3179 | 64240879 |
Patient uncooperative | 35.17 | 9.64 | 24 | 254650 | 543 | 64243515 |
Mobility decreased | 33.77 | 9.64 | 501 | 254173 | 85339 | 64158719 |
Hepatic function abnormal | 33.67 | 9.64 | 135 | 254539 | 64178 | 64179880 |
Rheumatoid nodule | 33.45 | 9.64 | 5 | 254669 | 12646 | 64231412 |
Postoperative ileus | 33.26 | 9.64 | 29 | 254645 | 952 | 64243106 |
Mydriasis | 33.12 | 9.64 | 134 | 254540 | 15178 | 64228880 |
Sinus tachycardia | 32.95 | 9.64 | 229 | 254445 | 31959 | 64212099 |
Transient ischaemic attack | 32.89 | 9.64 | 79 | 254595 | 44103 | 64199955 |
Diaphragmatic spasm | 32.69 | 9.64 | 13 | 254661 | 88 | 64243970 |
Disease progression | 32.68 | 9.64 | 761 | 253913 | 140919 | 64103139 |
Drug use disorder | 32.41 | 9.64 | 73 | 254601 | 5981 | 64238077 |
Full blood count abnormal | 32.30 | 9.64 | 42 | 254632 | 29715 | 64214343 |
Tubulointerstitial nephritis | 32.16 | 9.64 | 45 | 254629 | 30864 | 64213194 |
Aggression | 32.11 | 9.64 | 301 | 254373 | 45931 | 64198127 |
Soft tissue disorder | 31.90 | 9.64 | 51 | 254623 | 3225 | 64240833 |
Impaired healing | 31.62 | 9.64 | 127 | 254547 | 60346 | 64183712 |
Therapy interrupted | 31.62 | 9.64 | 20 | 254654 | 20016 | 64224042 |
Melaena | 31.58 | 9.64 | 107 | 254567 | 53441 | 64190617 |
Disorientation | 31.36 | 9.64 | 348 | 254326 | 55480 | 64188578 |
Small intestinal obstruction | 31.15 | 9.64 | 179 | 254495 | 23394 | 64220664 |
Tendonitis | 30.98 | 9.64 | 21 | 254653 | 20261 | 64223797 |
Neutropenic sepsis | 30.94 | 9.64 | 177 | 254497 | 23095 | 64220963 |
Metastases to bone | 30.92 | 9.64 | 161 | 254513 | 20274 | 64223784 |
Weaning failure | 30.78 | 9.64 | 23 | 254651 | 603 | 64243455 |
Stupor | 30.35 | 9.64 | 71 | 254603 | 5964 | 64238094 |
Multiple sclerosis relapse | 30.26 | 9.64 | 74 | 254600 | 41061 | 64202997 |
Pneumonia aspiration | 29.96 | 9.64 | 362 | 254312 | 58909 | 64185149 |
Cardiac failure | 29.63 | 9.64 | 357 | 254317 | 132016 | 64112042 |
Bone marrow failure | 29.53 | 9.64 | 94 | 254580 | 47858 | 64196200 |
Obliterative bronchiolitis | 29.47 | 9.64 | 44 | 254630 | 2621 | 64241437 |
Therapy cessation | 29.34 | 9.64 | 52 | 254622 | 32437 | 64211621 |
Blister | 29.33 | 9.64 | 193 | 254481 | 80774 | 64163284 |
Tonsillar disorder | 28.83 | 9.64 | 27 | 254647 | 974 | 64243084 |
Myopathy | 28.80 | 9.64 | 17 | 254657 | 17663 | 64226395 |
Medication error | 28.77 | 9.64 | 313 | 254361 | 49653 | 64194405 |
Impaired work ability | 28.77 | 9.64 | 12 | 254662 | 15207 | 64228851 |
Intestinal obstruction | 28.67 | 9.64 | 243 | 254431 | 36043 | 64208015 |
Atrial fibrillation | 28.59 | 9.64 | 489 | 254185 | 170600 | 64073458 |
Tenosynovitis | 28.41 | 9.64 | 6 | 254668 | 11827 | 64232231 |
Pancreatic fibrosis | 28.37 | 9.64 | 12 | 254662 | 97 | 64243961 |
Granulocytopenia | 27.89 | 9.64 | 4 | 254670 | 10436 | 64233622 |
Carcinoid tumour | 27.88 | 9.64 | 19 | 254655 | 429 | 64243629 |
Breakthrough pain | 27.88 | 9.64 | 29 | 254645 | 1191 | 64242867 |
Incoherent | 27.71 | 9.64 | 76 | 254598 | 7042 | 64237016 |
Asthma | 27.40 | 9.64 | 242 | 254432 | 94983 | 64149075 |
Non-small cell lung cancer | 27.34 | 9.64 | 60 | 254614 | 4830 | 64239228 |
Eye pain | 27.33 | 9.64 | 52 | 254622 | 31573 | 64212485 |
Implant site extravasation | 27.22 | 9.64 | 23 | 254651 | 723 | 64243335 |
Neoplasm progression | 27.11 | 9.64 | 264 | 254410 | 40700 | 64203358 |
Faecal volume decreased | 27.10 | 9.64 | 13 | 254661 | 145 | 64243913 |
Injection site bruising | 27.10 | 9.64 | 65 | 254609 | 36308 | 64207750 |
Maternal exposure during pregnancy | 27.01 | 9.64 | 245 | 254429 | 95639 | 64148419 |
Immune reconstitution inflammatory syndrome | 26.70 | 9.64 | 8 | 254666 | 12462 | 64231596 |
Ischaemic stroke | 26.65 | 9.64 | 46 | 254628 | 28989 | 64215069 |
Chronic kidney disease | 26.43 | 9.64 | 128 | 254546 | 57791 | 64186267 |
Intentional product use issue | 26.28 | 9.64 | 245 | 254429 | 95119 | 64148939 |
Skin candida | 26.22 | 9.64 | 33 | 254641 | 1670 | 64242388 |
Product use issue | 25.88 | 9.64 | 432 | 254242 | 151283 | 64092775 |
Vascular resistance systemic decreased | 25.67 | 9.64 | 14 | 254660 | 208 | 64243850 |
Sepsis neonatal | 25.57 | 9.64 | 9 | 254665 | 41 | 64244017 |
Calcium deficiency | 25.39 | 9.64 | 22 | 254652 | 716 | 64243342 |
Carcinoid crisis | 25.31 | 9.64 | 18 | 254656 | 436 | 64243622 |
PCO2 increased | 25.19 | 9.64 | 32 | 254642 | 1635 | 64242423 |
Pathogen resistance | 25.18 | 9.64 | 9 | 254665 | 12534 | 64231524 |
Hypertension | 25.08 | 9.64 | 806 | 253868 | 258455 | 63985603 |
Myocardial fibrosis | 24.94 | 9.64 | 31 | 254643 | 1549 | 64242509 |
Sternal fracture | 24.71 | 9.64 | 37 | 254637 | 2210 | 64241848 |
Intentional self-injury | 24.02 | 9.64 | 49 | 254625 | 28995 | 64215063 |
Drug withdrawal syndrome neonatal | 24.01 | 9.64 | 14 | 254660 | 238 | 64243820 |
Gallbladder cholesterolosis | 23.99 | 9.64 | 19 | 254655 | 544 | 64243514 |
Renal impairment | 23.83 | 9.64 | 382 | 254292 | 134635 | 64109423 |
Herpes simplex viraemia | 23.76 | 9.64 | 14 | 254660 | 243 | 64243815 |
Blood glucose increased | 23.70 | 9.64 | 260 | 254414 | 97813 | 64146245 |
Product name confusion | 23.68 | 9.64 | 12 | 254662 | 152 | 64243906 |
Neurological examination abnormal | 23.25 | 9.64 | 18 | 254656 | 498 | 64243560 |
Fluid retention | 23.17 | 9.64 | 139 | 254535 | 59467 | 64184591 |
Throat irritation | 23.17 | 9.64 | 60 | 254614 | 32651 | 64211407 |
Parkinsonism | 23.16 | 9.64 | 14 | 254660 | 14359 | 64229699 |
Injection site rash | 23.12 | 9.64 | 17 | 254657 | 15725 | 64228333 |
Drug-induced liver injury | 23.09 | 9.64 | 103 | 254571 | 47540 | 64196518 |
Occupational dermatitis | 23.07 | 9.64 | 11 | 254663 | 121 | 64243937 |
Tumour pain | 22.95 | 9.64 | 33 | 254641 | 1900 | 64242158 |
Sickle cell anaemia with crisis | 22.85 | 9.64 | 59 | 254615 | 5273 | 64238785 |
Sepsis | 22.76 | 9.64 | 1120 | 253554 | 229221 | 64014837 |
Pain in extremity | 22.66 | 9.64 | 972 | 253702 | 302113 | 63941945 |
Cholestasis | 22.65 | 9.64 | 274 | 254400 | 44598 | 64199460 |
Neuralgia | 22.65 | 9.64 | 179 | 254495 | 26005 | 64218053 |
Drug level | 22.62 | 9.64 | 6 | 254668 | 7 | 64244051 |
Systemic mastocytosis | 22.56 | 9.64 | 14 | 254660 | 268 | 64243790 |
Palpitations | 22.55 | 9.64 | 284 | 254390 | 104204 | 64139854 |
Buttock injury | 22.38 | 9.64 | 11 | 254663 | 130 | 64243928 |
Hallucination, visual | 22.31 | 9.64 | 187 | 254487 | 27647 | 64216411 |
Eczema | 22.23 | 9.64 | 53 | 254621 | 29667 | 64214391 |
Bronchitis | 22.20 | 9.64 | 299 | 254375 | 108444 | 64135614 |
Infusion site granuloma | 22.18 | 9.64 | 6 | 254668 | 8 | 64244050 |
PO2 decreased | 22.11 | 9.64 | 39 | 254635 | 2674 | 64241384 |
White blood cell count decreased | 22.09 | 9.64 | 465 | 254209 | 157372 | 64086686 |
Heavy menstrual bleeding | 22.07 | 9.64 | 10 | 254664 | 12067 | 64231991 |
Neuropathy peripheral | 21.93 | 9.64 | 329 | 254345 | 117196 | 64126862 |
Eosinophilia | 21.83 | 9.64 | 77 | 254597 | 37999 | 64206059 |
Apnoeic attack | 21.65 | 9.64 | 18 | 254656 | 553 | 64243505 |
Myelosuppression | 21.65 | 9.64 | 38 | 254636 | 23792 | 64220266 |
Liver disorder | 21.49 | 9.64 | 123 | 254551 | 53228 | 64190830 |
Gout | 21.46 | 9.64 | 32 | 254642 | 21381 | 64222677 |
Implant site discharge | 21.46 | 9.64 | 11 | 254663 | 143 | 64243915 |
Rash pruritic | 21.21 | 9.64 | 136 | 254538 | 57268 | 64186790 |
Infective pulmonary exacerbation of cystic fibrosis | 21.19 | 9.64 | 10 | 254664 | 11786 | 64232272 |
Hypopnoea | 21.14 | 9.64 | 42 | 254632 | 3152 | 64240906 |
Schizophrenia | 20.80 | 9.64 | 9 | 254665 | 11159 | 64232899 |
Salivary hypersecretion | 20.66 | 9.64 | 11 | 254663 | 12102 | 64231956 |
Pulseless electrical activity | 20.42 | 9.64 | 102 | 254572 | 12637 | 64231421 |
Respiratory rate increased | 20.31 | 9.64 | 133 | 254541 | 18198 | 64225860 |
Glycosylated haemoglobin increased | 20.23 | 9.64 | 20 | 254654 | 15999 | 64228059 |
Failure to suspend medication | 20.18 | 9.64 | 15 | 254659 | 390 | 64243668 |
Aspergillus infection | 20.06 | 9.64 | 21 | 254653 | 16358 | 64227700 |
Victim of homicide | 20.02 | 9.64 | 11 | 254663 | 166 | 64243892 |
Haematuria | 20 | 9.64 | 148 | 254526 | 60323 | 64183735 |
Prescribed underdose | 20.00 | 9.64 | 25 | 254649 | 17990 | 64226068 |
Diabetes mellitus | 19.98 | 9.64 | 167 | 254507 | 66307 | 64177751 |
Iron deficiency anaemia | 19.80 | 9.64 | 35 | 254639 | 21854 | 64222204 |
Discomfort | 19.70 | 9.64 | 214 | 254460 | 80664 | 64163394 |
Anaesthetic complication | 19.65 | 9.64 | 36 | 254638 | 2543 | 64241515 |
Cerebrospinal fluid leakage | 19.53 | 9.64 | 25 | 254649 | 1287 | 64242771 |
Duodenal ulcer | 19.43 | 9.64 | 17 | 254657 | 14418 | 64229640 |
Administration site induration | 19.24 | 9.64 | 6 | 254668 | 17 | 64244041 |
Administration site abscess | 19.24 | 9.64 | 6 | 254668 | 17 | 64244041 |
Alveolitis | 19.19 | 9.64 | 44 | 254630 | 3648 | 64240410 |
Blood pH increased | 19.17 | 9.64 | 24 | 254650 | 1208 | 64242850 |
Pemphigoid | 19.10 | 9.64 | 14 | 254660 | 12972 | 64231086 |
Splenic injury | 19.10 | 9.64 | 12 | 254662 | 235 | 64243823 |
Pneumonia viral | 18.99 | 9.64 | 71 | 254603 | 7751 | 64236307 |
Epstein-Barr virus infection | 18.98 | 9.64 | 13 | 254661 | 12475 | 64231583 |
Hepatocellular injury | 18.97 | 9.64 | 267 | 254407 | 44968 | 64199090 |
Femur fracture | 18.93 | 9.64 | 70 | 254604 | 34065 | 64209993 |
Incorrect route of product administration | 18.92 | 9.64 | 157 | 254517 | 23141 | 64220917 |
Haematotoxicity | 18.85 | 9.64 | 14 | 254660 | 12882 | 64231176 |
Agonal death struggle | 18.77 | 9.64 | 5 | 254669 | 6 | 64244052 |
Iodine allergy | 18.69 | 9.64 | 16 | 254658 | 512 | 64243546 |
Gastrooesophageal reflux disease | 18.69 | 9.64 | 224 | 254450 | 82919 | 64161139 |
Thrombotic microangiopathy | 18.60 | 9.64 | 23 | 254651 | 16632 | 64227426 |
Pneumocystis jirovecii pneumonia | 18.58 | 9.64 | 52 | 254622 | 27582 | 64216476 |
Hypercholesterolaemia | 18.50 | 9.64 | 20 | 254654 | 15353 | 64228705 |
Hyponatraemia | 18.49 | 9.64 | 445 | 254229 | 147894 | 64096164 |
Low density lipoprotein increased | 18.43 | 9.64 | 4 | 254670 | 7736 | 64236322 |
Drug tolerance increased | 18.37 | 9.64 | 17 | 254657 | 604 | 64243454 |
Retinitis | 18.34 | 9.64 | 31 | 254643 | 2054 | 64242004 |
Administration site haemorrhage | 18.31 | 9.64 | 7 | 254667 | 42 | 64244016 |
Visual acuity reduced | 18.30 | 9.64 | 51 | 254623 | 27090 | 64216968 |
Blood cholesterol increased | 18.30 | 9.64 | 119 | 254555 | 49947 | 64194111 |
Device difficult to use | 18.08 | 9.64 | 8 | 254666 | 9790 | 64234268 |
Pathological fracture | 18.06 | 9.64 | 77 | 254597 | 8928 | 64235130 |
Cushingoid | 17.96 | 9.64 | 4 | 254670 | 7599 | 64236459 |
Haemophagocytic lymphohistiocytosis | 17.96 | 9.64 | 26 | 254648 | 17583 | 64226475 |
Hypoacusis | 17.90 | 9.64 | 48 | 254626 | 25819 | 64218239 |
Biliary obstruction | 17.86 | 9.64 | 44 | 254630 | 3820 | 64240238 |
Intensive care | 17.82 | 9.64 | 17 | 254657 | 628 | 64243430 |
Substance dependence | 17.66 | 9.64 | 15 | 254659 | 475 | 64243583 |
Muscle twitching | 17.62 | 9.64 | 132 | 254542 | 18866 | 64225192 |
Device failure | 17.60 | 9.64 | 56 | 254618 | 5636 | 64238422 |
Anaesthesia | 17.55 | 9.64 | 14 | 254660 | 405 | 64243653 |
Accidental poisoning | 17.54 | 9.64 | 25 | 254649 | 1428 | 64242630 |
Administration site discharge | 17.48 | 9.64 | 6 | 254668 | 25 | 64244033 |
Acute graft versus host disease in skin | 17.47 | 9.64 | 3 | 254671 | 6852 | 64237206 |
Inflammation | 17.46 | 9.64 | 169 | 254505 | 65131 | 64178927 |
Medical device site infection | 17.44 | 9.64 | 14 | 254660 | 409 | 64243649 |
Type 2 diabetes mellitus | 17.44 | 9.64 | 72 | 254602 | 33948 | 64210110 |
Acute graft versus host disease | 17.43 | 9.64 | 7 | 254667 | 9077 | 64234981 |
Retrograde amnesia | 17.42 | 9.64 | 15 | 254659 | 484 | 64243574 |
Photosensitivity reaction | 17.41 | 9.64 | 28 | 254646 | 18145 | 64225913 |
Lymphocyte count decreased | 17.40 | 9.64 | 92 | 254582 | 40607 | 64203451 |
Gangrene | 17.31 | 9.64 | 66 | 254608 | 7272 | 64236786 |
Administration site odour | 17.29 | 9.64 | 6 | 254668 | 26 | 64244032 |
Neuroendocrine tumour of the lung | 17.29 | 9.64 | 6 | 254668 | 26 | 64244032 |
Urinary tract infection | 17.24 | 9.64 | 743 | 253931 | 230853 | 64013205 |
Postmortem blood drug level increased | 17.23 | 9.64 | 18 | 254656 | 743 | 64243315 |
Myelodysplastic syndrome | 17.03 | 9.64 | 54 | 254620 | 27525 | 64216533 |
Diffuse axonal injury | 16.94 | 9.64 | 8 | 254666 | 86 | 64243972 |
Renal disorder | 16.81 | 9.64 | 77 | 254597 | 35288 | 64208770 |
Panniculitis | 16.78 | 9.64 | 7 | 254667 | 8872 | 64235186 |
Pulmonary tuberculosis | 16.74 | 9.64 | 4 | 254670 | 7240 | 64236818 |
Reaction to excipient | 16.73 | 9.64 | 24 | 254650 | 1379 | 64242679 |
Metastasis | 16.68 | 9.64 | 55 | 254619 | 5640 | 64238418 |
Hepatitis B | 16.53 | 9.64 | 5 | 254669 | 7740 | 64236318 |
Anaphylactic reaction | 16.50 | 9.64 | 371 | 254303 | 68293 | 64175765 |
Osteoarthritis | 16.48 | 9.64 | 165 | 254509 | 63171 | 64180887 |
Restlessness | 16.35 | 9.64 | 234 | 254440 | 39551 | 64204507 |
Toxic leukoencephalopathy | 16.15 | 9.64 | 19 | 254655 | 896 | 64243162 |
Device computer issue | 16.13 | 9.64 | 6 | 254668 | 33 | 64244025 |
Blood alkaline phosphatase increased | 16.11 | 9.64 | 312 | 254362 | 55967 | 64188091 |
Enthesopathy | 16.08 | 9.64 | 9 | 254665 | 9629 | 64234429 |
Body temperature increased | 16.02 | 9.64 | 218 | 254456 | 36448 | 64207610 |
Squamous cell carcinoma of skin | 15.97 | 9.64 | 14 | 254660 | 11862 | 64232196 |
Disease recurrence | 15.95 | 9.64 | 67 | 254607 | 31443 | 64212615 |
Nephrotic syndrome | 15.87 | 9.64 | 9 | 254665 | 9558 | 64234500 |
Spinal epidural haemorrhage | 15.86 | 9.64 | 9 | 254665 | 145 | 64243913 |
Head discomfort | 15.86 | 9.64 | 14 | 254660 | 11820 | 64232238 |
Hallucination, tactile | 15.82 | 9.64 | 14 | 254660 | 469 | 64243589 |
Cerebral infarction | 15.80 | 9.64 | 96 | 254578 | 40948 | 64203110 |
Central nervous system injury | 15.75 | 9.64 | 9 | 254665 | 147 | 64243911 |
Acute respiratory failure | 15.74 | 9.64 | 281 | 254393 | 49653 | 64194405 |
Abdominal pain | 15.72 | 9.64 | 1435 | 253239 | 310940 | 63933118 |
Tuberculosis | 15.65 | 9.64 | 17 | 254657 | 13021 | 64231037 |
Injection site cyst | 15.62 | 9.64 | 7 | 254667 | 66 | 64243992 |
Angina unstable | 15.61 | 9.64 | 23 | 254651 | 15444 | 64228614 |
Dose calculation error | 15.59 | 9.64 | 9 | 254665 | 150 | 64243908 |
Asthenia | 15.52 | 9.64 | 1467 | 253207 | 426577 | 63817481 |
Clonus | 15.51 | 9.64 | 56 | 254618 | 6011 | 64238047 |
Wrong product administered | 15.47 | 9.64 | 66 | 254608 | 7654 | 64236404 |
Vision blurred | 15.45 | 9.64 | 257 | 254417 | 90059 | 64153999 |
Intentional misuse of drug delivery system | 15.40 | 9.64 | 4 | 254670 | 4 | 64244054 |
Psoriatic arthropathy | 15.25 | 9.64 | 104 | 254570 | 43177 | 64200881 |
Hip arthroplasty | 15.25 | 9.64 | 39 | 254635 | 21312 | 64222746 |
Secondary hypogonadism | 15.08 | 9.64 | 12 | 254662 | 346 | 64243712 |
Mitral valve incompetence | 15.08 | 9.64 | 51 | 254623 | 25487 | 64218571 |
Dependence | 15.07 | 9.64 | 29 | 254645 | 2126 | 64241932 |
Pulmonary haemorrhage | 15.07 | 9.64 | 96 | 254578 | 13013 | 64231045 |
Metastases to eye | 15.06 | 9.64 | 10 | 254664 | 216 | 64243842 |
Jaundice | 14.98 | 9.64 | 121 | 254553 | 48391 | 64195667 |
Thymus disorder | 14.94 | 9.64 | 10 | 254664 | 219 | 64243839 |
Transplant dysfunction | 14.93 | 9.64 | 4 | 254670 | 6704 | 64237354 |
Paradoxical drug reaction | 14.91 | 9.64 | 3 | 254671 | 6117 | 64237941 |
Oropharyngeal pain | 14.83 | 9.64 | 254 | 254420 | 88613 | 64155445 |
Anaemia | 14.71 | 9.64 | 1291 | 253383 | 377389 | 63866669 |
Neuroleptic malignant syndrome | 14.70 | 9.64 | 50 | 254624 | 24946 | 64219112 |
Product quality issue | 14.70 | 9.64 | 64 | 254610 | 29735 | 64214323 |
Dehydration | 14.69 | 9.64 | 1019 | 253655 | 215744 | 64028314 |
Joint effusion | 14.64 | 9.64 | 19 | 254655 | 13454 | 64230604 |
Squamous cell carcinoma | 14.62 | 9.64 | 20 | 254654 | 13849 | 64230209 |
Soft tissue injury | 14.59 | 9.64 | 24 | 254650 | 1555 | 64242503 |
Internal haemorrhage | 14.56 | 9.64 | 6 | 254668 | 7661 | 64236397 |
Cardiac output decreased | 14.54 | 9.64 | 25 | 254649 | 1679 | 64242379 |
Depression | 14.49 | 9.64 | 584 | 254090 | 182707 | 64061351 |
Acute myocardial infarction | 14.48 | 9.64 | 191 | 254483 | 69527 | 64174531 |
Back pain | 14.43 | 9.64 | 1161 | 253513 | 249010 | 63995048 |
PO2 abnormal | 14.35 | 9.64 | 5 | 254669 | 22 | 64244036 |
Red blood cell count decreased | 14.34 | 9.64 | 122 | 254552 | 48264 | 64195794 |
Peripheral nerve injury | 14.32 | 9.64 | 15 | 254659 | 621 | 64243437 |
Blood chromogranin A increased | 14.31 | 9.64 | 12 | 254662 | 373 | 64243685 |
Surgery | 14.28 | 9.64 | 60 | 254614 | 28153 | 64215905 |
Limb discomfort | 14.25 | 9.64 | 57 | 254617 | 27118 | 64216940 |
Gastrointestinal hypomotility | 14.24 | 9.64 | 25 | 254649 | 1708 | 64242350 |
Suicide attempt | 14.22 | 9.64 | 196 | 254478 | 70811 | 64173247 |
Platelet count decreased | 14.21 | 9.64 | 530 | 254144 | 167181 | 64076877 |
Hyperlipidaemia | 14.17 | 9.64 | 45 | 254629 | 22931 | 64221127 |
Stomatitis | 14.15 | 9.64 | 327 | 254347 | 109278 | 64134780 |
Megacolon | 14.15 | 9.64 | 35 | 254639 | 3047 | 64241011 |
Breast cancer metastatic | 14.14 | 9.64 | 61 | 254613 | 7108 | 64236950 |
Breast cancer | 14.13 | 9.64 | 63 | 254611 | 29085 | 64214973 |
Epidural analgesia | 14.13 | 9.64 | 6 | 254668 | 49 | 64244009 |
Increased bronchial secretion | 13.82 | 9.64 | 33 | 254641 | 2809 | 64241249 |
Spinal cord injury | 13.82 | 9.64 | 18 | 254656 | 943 | 64243115 |
Alanine aminotransferase abnormal | 13.73 | 9.64 | 5 | 254669 | 6883 | 64237175 |
Colitis microscopic | 13.72 | 9.64 | 62 | 254612 | 7370 | 64236688 |
Basal ganglion degeneration | 13.71 | 9.64 | 12 | 254662 | 396 | 64243662 |
Sinus congestion | 13.68 | 9.64 | 25 | 254649 | 15414 | 64228644 |
Myoglobin urine | 13.67 | 9.64 | 5 | 254669 | 26 | 64244032 |
Opiates | 13.62 | 9.64 | 3 | 254671 | 0 | 64244058 |
Femoral pulse abnormal | 13.62 | 9.64 | 3 | 254671 | 0 | 64244058 |
Demyelination | 13.56 | 9.64 | 5 | 254669 | 6829 | 64237229 |
Fibrinolysis | 13.44 | 9.64 | 6 | 254668 | 56 | 64244002 |
Nodule | 13.43 | 9.64 | 32 | 254642 | 17915 | 64226143 |
Erythema multiforme | 13.41 | 9.64 | 26 | 254648 | 15675 | 64228383 |
Antinuclear antibody positive | 13.40 | 9.64 | 4 | 254670 | 6246 | 64237812 |
Hostility | 13.40 | 9.64 | 28 | 254646 | 2179 | 64241879 |
Proteinuria | 13.39 | 9.64 | 60 | 254614 | 27663 | 64216395 |
Cystitis | 13.38 | 9.64 | 106 | 254568 | 42569 | 64201489 |
Arachnoiditis | 13.33 | 9.64 | 15 | 254659 | 674 | 64243384 |
End stage renal disease | 13.32 | 9.64 | 13 | 254661 | 10462 | 64233596 |
Needle issue | 13.31 | 9.64 | 72 | 254602 | 9200 | 64234858 |
Knee arthroplasty | 13.31 | 9.64 | 58 | 254616 | 26941 | 64217117 |
Hypertensive crisis | 13.29 | 9.64 | 33 | 254641 | 18215 | 64225843 |
Performance status decreased | 13.28 | 9.64 | 49 | 254625 | 5315 | 64238743 |
Lactic acidosis | 13.21 | 9.64 | 167 | 254507 | 61243 | 64182815 |
Blood phosphorus decreased | 13.20 | 9.64 | 51 | 254623 | 5654 | 64238404 |
Cardiac failure acute | 13.16 | 9.64 | 28 | 254646 | 16316 | 64227742 |
Exercise tolerance decreased | 13.15 | 9.64 | 7 | 254667 | 7703 | 64236355 |
Therapeutic response decreased | 13.15 | 9.64 | 137 | 254537 | 52051 | 64192007 |
Gastrointestinal haemorrhage | 13.10 | 9.64 | 410 | 254264 | 131902 | 64112156 |
Kidney transplant rejection | 13.05 | 9.64 | 11 | 254663 | 9500 | 64234558 |
Diabetes mellitus inadequate control | 12.99 | 9.64 | 42 | 254632 | 21279 | 64222779 |
Rhythm idioventricular | 12.98 | 9.64 | 13 | 254661 | 510 | 64243548 |
Cardiac failure chronic | 12.98 | 9.64 | 10 | 254664 | 9031 | 64235027 |
Optic neuritis | 12.95 | 9.64 | 8 | 254666 | 8108 | 64235950 |
Stroke volume increased | 12.91 | 9.64 | 4 | 254670 | 11 | 64244047 |
Skin cancer | 12.89 | 9.64 | 17 | 254657 | 11957 | 64232101 |
Genital haemorrhage | 12.85 | 9.64 | 3 | 254671 | 5519 | 64238539 |
Hypogammaglobulinaemia | 12.84 | 9.64 | 13 | 254661 | 10286 | 64233772 |
Paraplegia | 12.83 | 9.64 | 43 | 254631 | 4447 | 64239611 |
Anamnestic reaction | 12.81 | 9.64 | 5 | 254669 | 32 | 64244026 |
Electrocardiogram low voltage | 12.81 | 9.64 | 5 | 254669 | 32 | 64244026 |
Injection site induration | 12.67 | 9.64 | 10 | 254664 | 8922 | 64235136 |
Insomnia | 12.66 | 9.64 | 645 | 254029 | 197191 | 64046867 |
Septic necrosis | 12.66 | 9.64 | 4 | 254670 | 12 | 64244046 |
Injection site warmth | 12.65 | 9.64 | 21 | 254653 | 13441 | 64230617 |
Product monitoring error | 12.62 | 9.64 | 3 | 254671 | 5451 | 64238607 |
Feeling jittery | 12.62 | 9.64 | 14 | 254660 | 10621 | 64233437 |
Nervous system disorder | 12.57 | 9.64 | 143 | 254531 | 22935 | 64221123 |
Pulse absent | 12.53 | 9.64 | 69 | 254605 | 8877 | 64235181 |
Delayed recovery from anaesthesia | 12.50 | 9.64 | 22 | 254652 | 1506 | 64242552 |
Substance use | 12.50 | 9.64 | 14 | 254660 | 626 | 64243432 |
Vascular malformation | 12.46 | 9.64 | 10 | 254664 | 292 | 64243766 |
Polyarthritis | 12.42 | 9.64 | 12 | 254662 | 9703 | 64234355 |
Ileus | 12.37 | 9.64 | 142 | 254532 | 22824 | 64221234 |
Infection | 12.36 | 9.64 | 600 | 254074 | 184280 | 64059778 |
Eosinophilic myocarditis | 12.32 | 9.64 | 16 | 254658 | 836 | 64243222 |
Product storage error | 12.31 | 9.64 | 21 | 254653 | 13297 | 64230761 |
Cluster headache | 12.30 | 9.64 | 16 | 254658 | 837 | 64243221 |
Tachycardia | 12.30 | 9.64 | 715 | 253959 | 148864 | 64095194 |
Paraparesis | 12.28 | 9.64 | 36 | 254638 | 3466 | 64240592 |
Theft | 12.27 | 9.64 | 9 | 254665 | 229 | 64243829 |
Pituitary apoplexy | 12.20 | 9.64 | 8 | 254666 | 169 | 64243889 |
Chest discomfort | 12.18 | 9.64 | 357 | 254317 | 115749 | 64128309 |
Cardiomyopathy | 12.18 | 9.64 | 55 | 254619 | 25301 | 64218757 |
Suicidal ideation | 12.16 | 9.64 | 187 | 254487 | 66355 | 64177703 |
Injection site discolouration | 12.09 | 9.64 | 6 | 254668 | 6869 | 64237189 |
Pocket erosion | 12.08 | 9.64 | 5 | 254669 | 38 | 64244020 |
Epidural haemorrhage | 12.08 | 9.64 | 8 | 254666 | 172 | 64243886 |
Large intestine polyp | 12.07 | 9.64 | 15 | 254659 | 10822 | 64233236 |
Nephrosclerosis | 12.06 | 9.64 | 22 | 254652 | 1549 | 64242509 |
Bronchopulmonary aspergillosis | 12.04 | 9.64 | 37 | 254637 | 19048 | 64225010 |
Dysphonia | 12.00 | 9.64 | 121 | 254553 | 46261 | 64197797 |
Parathyroid hormone-related protein abnormal | 11.98 | 9.64 | 4 | 254670 | 15 | 64244043 |
Coronary artery bypass | 11.97 | 9.64 | 4 | 254670 | 5811 | 64238247 |
Agranulocytosis | 11.96 | 9.64 | 95 | 254579 | 38134 | 64205924 |
Sleep disorder due to a general medical condition | 11.95 | 9.64 | 9 | 254665 | 8225 | 64235833 |
Cataract | 11.95 | 9.64 | 137 | 254537 | 51125 | 64192933 |
Antasthmatic drug level | 11.86 | 9.64 | 5 | 254669 | 40 | 64244018 |
Cardiac murmur | 11.86 | 9.64 | 17 | 254657 | 11546 | 64232512 |
Immunosuppressant drug level increased | 11.80 | 9.64 | 7 | 254667 | 7252 | 64236806 |
Onychomycosis | 11.75 | 9.64 | 3 | 254671 | 5193 | 64238865 |
Leukopenia | 11.72 | 9.64 | 307 | 254367 | 100935 | 64143123 |
Stridor | 11.63 | 9.64 | 44 | 254630 | 4830 | 64239228 |
Tissue infiltration | 11.63 | 9.64 | 13 | 254661 | 580 | 64243478 |
Haemorrhage | 11.62 | 9.64 | 232 | 254442 | 79119 | 64164939 |
Blood triglycerides increased | 11.60 | 9.64 | 37 | 254637 | 18829 | 64225229 |
Analgesic therapy | 11.55 | 9.64 | 3 | 254671 | 3 | 64244055 |
Inappropriate antidiuretic hormone secretion | 11.53 | 9.64 | 47 | 254627 | 22242 | 64221816 |
Cardiac output increased | 11.50 | 9.64 | 8 | 254666 | 187 | 64243871 |
Malignant melanoma | 11.48 | 9.64 | 21 | 254653 | 12943 | 64231115 |
Drug reaction with eosinophilia and systemic symptoms | 11.46 | 9.64 | 148 | 254526 | 54069 | 64189989 |
Analgesic drug level | 11.45 | 9.64 | 5 | 254669 | 44 | 64244014 |
Lymphoproliferative disorder | 11.44 | 9.64 | 3 | 254671 | 5100 | 64238958 |
Excessive eye blinking | 11.44 | 9.64 | 19 | 254655 | 1241 | 64242817 |
Device toxicity | 11.41 | 9.64 | 4 | 254670 | 18 | 64244040 |
Dyspepsia | 11.41 | 9.64 | 236 | 254438 | 80076 | 64163982 |
Psychotic behaviour | 11.40 | 9.64 | 17 | 254657 | 1012 | 64243046 |
Intercepted product dispensing error | 11.37 | 9.64 | 7 | 254667 | 132 | 64243926 |
Large intestine perforation | 11.36 | 9.64 | 87 | 254587 | 12517 | 64231541 |
Spinal cord paralysis | 11.32 | 9.64 | 7 | 254667 | 133 | 64243925 |
Paranasal cyst | 11.32 | 9.64 | 10 | 254664 | 334 | 64243724 |
Influenza | 11.31 | 9.64 | 327 | 254347 | 106204 | 64137854 |
Alkalosis | 11.23 | 9.64 | 11 | 254663 | 420 | 64243638 |
Libido increased | 11.21 | 9.64 | 23 | 254651 | 1767 | 64242291 |
Foetal monitoring abnormal | 11.19 | 9.64 | 7 | 254667 | 136 | 64243922 |
Cardiac pacemaker insertion | 11.17 | 9.64 | 3 | 254671 | 5020 | 64239038 |
Analgesic drug level above therapeutic | 11.17 | 9.64 | 11 | 254663 | 423 | 64243635 |
Toxic skin eruption | 11.05 | 9.64 | 39 | 254635 | 19245 | 64224813 |
Red blood cell sedimentation rate increased | 11.03 | 9.64 | 75 | 254599 | 31160 | 64212898 |
Gastric dilatation | 11.01 | 9.64 | 18 | 254656 | 1160 | 64242898 |
Muscle swelling | 11.01 | 9.64 | 14 | 254660 | 716 | 64243342 |
Abdominal compartment syndrome | 10.96 | 9.64 | 20 | 254654 | 1408 | 64242650 |
Snoring | 10.95 | 9.64 | 42 | 254632 | 4640 | 64239418 |
Hyperthyroidism | 10.94 | 9.64 | 36 | 254638 | 18143 | 64225915 |
Polyneuropathy | 10.90 | 9.64 | 41 | 254633 | 19853 | 64224205 |
Fear-related avoidance of activities | 10.89 | 9.64 | 6 | 254668 | 91 | 64243967 |
Brain death | 10.88 | 9.64 | 43 | 254631 | 4818 | 64239240 |
Aplastic anaemia | 10.88 | 9.64 | 93 | 254581 | 13827 | 64230231 |
Device use error | 10.86 | 9.64 | 6 | 254668 | 6465 | 64237593 |
Haemorrhagic stroke | 10.85 | 9.64 | 14 | 254660 | 9937 | 64234121 |
Cardiac disorder | 10.84 | 9.64 | 155 | 254519 | 55661 | 64188397 |
Abdominal pain upper | 10.75 | 9.64 | 573 | 254101 | 174457 | 64069601 |
Dysarthria | 10.74 | 9.64 | 309 | 254365 | 59097 | 64184961 |
Blood pressure diastolic increased | 10.71 | 9.64 | 76 | 254598 | 10676 | 64233382 |
Viral upper respiratory tract infection | 10.67 | 9.64 | 10 | 254664 | 8205 | 64235853 |
Bladder dilatation | 10.65 | 9.64 | 23 | 254651 | 1831 | 64242227 |
Sitting disability | 10.63 | 9.64 | 7 | 254667 | 149 | 64243909 |
Leukoencephalopathy | 10.62 | 9.64 | 55 | 254619 | 6912 | 64237146 |
Nerve injury | 10.58 | 9.64 | 59 | 254615 | 7626 | 64236432 |
Monocytopenia | 10.55 | 9.64 | 7 | 254667 | 151 | 64243907 |
Labelled drug-drug interaction medication error | 10.51 | 9.64 | 48 | 254626 | 22014 | 64222044 |
Metastases to spine | 10.51 | 9.64 | 35 | 254639 | 3608 | 64240450 |
Laboratory test abnormal | 10.51 | 9.64 | 54 | 254620 | 24009 | 64220049 |
Catheter site phlebitis | 10.47 | 9.64 | 4 | 254670 | 24 | 64244034 |
Mastoid disorder | 10.47 | 9.64 | 4 | 254670 | 24 | 64244034 |
Pulmonary toxicity | 10.46 | 9.64 | 11 | 254663 | 8550 | 64235508 |
Faecaloma | 10.42 | 9.64 | 70 | 254604 | 9658 | 64234400 |
Accident | 10.40 | 9.64 | 54 | 254620 | 6792 | 64237266 |
Foetal megacystis | 10.34 | 9.64 | 3 | 254671 | 6 | 64244052 |
Scan gallium abnormal | 10.33 | 9.64 | 4 | 254670 | 25 | 64244033 |
Urine alcohol test positive | 10.33 | 9.64 | 4 | 254670 | 25 | 64244033 |
Perineal pain | 10.30 | 9.64 | 16 | 254658 | 987 | 64243071 |
Hypoglycaemia | 10.30 | 9.64 | 273 | 254401 | 89619 | 64154439 |
Chronic graft versus host disease | 10.27 | 9.64 | 6 | 254668 | 6270 | 64237788 |
Psychomotor skills impaired | 10.27 | 9.64 | 36 | 254638 | 3809 | 64240249 |
Pain in jaw | 10.26 | 9.64 | 107 | 254567 | 40648 | 64203410 |
Post-traumatic neck syndrome | 10.25 | 9.64 | 23 | 254651 | 1879 | 64242179 |
Catheter site granuloma | 10.25 | 9.64 | 5 | 254669 | 58 | 64244000 |
Intrapericardial thrombosis | 10.25 | 9.64 | 5 | 254669 | 58 | 64244000 |
Blood creatine phosphokinase MB increased | 10.22 | 9.64 | 28 | 254646 | 2593 | 64241465 |
Blood loss anaemia | 10.21 | 9.64 | 25 | 254649 | 13867 | 64230191 |
Areflexia | 10.18 | 9.64 | 43 | 254631 | 4964 | 64239094 |
Mediastinal shift | 10.18 | 9.64 | 5 | 254669 | 59 | 64243999 |
Cytomegalovirus infection reactivation | 10.16 | 9.64 | 5 | 254669 | 5751 | 64238307 |
Neurogenic bowel | 10.12 | 9.64 | 7 | 254667 | 162 | 64243896 |
Neuroblastoma | 10.12 | 9.64 | 7 | 254667 | 162 | 64243896 |
Increased tendency to bruise | 10.11 | 9.64 | 13 | 254661 | 9242 | 64234816 |
Head injury | 10.10 | 9.64 | 82 | 254592 | 32760 | 64211298 |
Mucosal inflammation | 10.10 | 9.64 | 321 | 254353 | 62263 | 64181795 |
Dyslipidaemia | 10.08 | 9.64 | 13 | 254661 | 9229 | 64234829 |
Laryngectomy | 10.07 | 9.64 | 4 | 254670 | 27 | 64244031 |
Electroencephalogram abnormal | 10.06 | 9.64 | 44 | 254630 | 5159 | 64238899 |
Skin papilloma | 10 | 9.64 | 4 | 254670 | 5199 | 64238859 |
Gastric ulcer | 9.99 | 9.64 | 74 | 254600 | 30160 | 64213898 |
Cheyne-Stokes respiration | 9.98 | 9.64 | 11 | 254663 | 483 | 64243575 |
Eosinophil count increased | 9.90 | 9.64 | 26 | 254648 | 14086 | 64229972 |
Medical device site haemorrhage | 9.90 | 9.64 | 7 | 254667 | 168 | 64243890 |
Actinic keratosis | 9.88 | 9.64 | 4 | 254670 | 5161 | 64238897 |
Eye irritation | 9.82 | 9.64 | 31 | 254643 | 15825 | 64228233 |
Adverse event | 9.81 | 9.64 | 104 | 254570 | 39385 | 64204673 |
Hypercreatininaemia | 9.80 | 9.64 | 14 | 254660 | 801 | 64243257 |
Dependence on oxygen therapy | 9.79 | 9.64 | 10 | 254664 | 402 | 64243656 |
Flushing | 9.77 | 9.64 | 236 | 254438 | 78412 | 64165646 |
Injection site haemorrhage | 9.76 | 9.64 | 56 | 254618 | 24222 | 64219836 |
Prostate cancer metastatic | 9.76 | 9.64 | 32 | 254642 | 3272 | 64240786 |
Clumsiness | 9.76 | 9.64 | 28 | 254646 | 2663 | 64241395 |
Anaesthetic complication pulmonary | 9.75 | 9.64 | 5 | 254669 | 65 | 64243993 |
Respiratory tract congestion | 9.74 | 9.64 | 32 | 254642 | 16133 | 64227925 |
Acute pulmonary oedema | 9.71 | 9.64 | 85 | 254589 | 12724 | 64231334 |
Amenorrhoea | 9.68 | 9.64 | 7 | 254667 | 6532 | 64237526 |
Glomerular filtration rate decreased | 9.67 | 9.64 | 42 | 254632 | 19530 | 64224528 |
None
Source | Code | Description |
---|---|---|
ATC | A07DA52 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS ANTIPROPULSIVES Antipropulsives |
ATC | N02AA01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AA51 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AG01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with antispasmodics |
ATC | R05DA05 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
CHEBI has role | CHEBI:35482 | narcotic analgesic |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:38867 | anaesthetic |
CHEBI has role | CHEBI:55322 | mu-opioid agonists |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
CHEBI has role | CHEBI:176497 | geroprotectors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
General anesthesia | indication | 50697003 | |
Diarrhea | indication | 62315008 | |
Severe pain | indication | 76948002 | |
Chronic pain | indication | 82423001 | |
Local anesthesia | indication | 386761002 | |
Acute postoperative pain | indication | 107401000119105 | |
Regional Anesthesia for Surgery | indication | ||
Regional Anesthesia for Labor Pain | indication | ||
Chronic Pain with Opioid Tolerance | indication | ||
Neuropathic pain | off-label use | 247398009 | |
Neonatal Abstinence Syndrome | off-label use | 414819007 | DOID:9828 |
Sedation in Intubated Patients | off-label use | ||
Neonatal Opioid Dependence | off-label use | ||
Brain damage | contraindication | 2470005 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Tachyarrhythmia | contraindication | 6285003 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Dyskinesia | contraindication | 9748009 | |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Acute vomiting | contraindication | 23971007 | |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Orthostatic hypotension | contraindication | 28651003 | |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Torsades de pointes | contraindication | 31722008 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Psychotic disorder | contraindication | 69322001 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Urethral stricture | contraindication | 76618002 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Prolonged QT interval | contraindication | 111975006 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Hypomagnesemia | contraindication | 190855004 | |
Alcohol withdrawal syndrome | contraindication | 191480000 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Chronic diarrhea | contraindication | 236071009 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Drowsy | contraindication | 271782001 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Central nervous system depression | contraindication | 418072004 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Predisposition to Nausea and Vomiting | contraindication | ||
Progressive Angina Pectoris | contraindication | ||
Severe Nausea | contraindication | ||
Pain in Opioid Naive Patients | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.71 | acidic |
pKa2 | 8.38 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
100MG;4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
20MG;0.8MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
30MG;1.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
50MG;2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
60MG;2.4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
80MG;3.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
100MG;4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
100MG;4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
20MG;0.8MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
20MG;0.8MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
30MG;1.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
30MG;1.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
50MG;2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
50MG;2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
60MG;2.4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
60MG;2.4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
80MG;3.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
80MG;3.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATEMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
100MG;4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
20MG;0.8MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
30MG;1.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
50MG;2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
60MG;2.4MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
80MG;3.2MG | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
15MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044402 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
15MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9549899 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
30MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044402 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
30MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9549899 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
60MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044402 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
60MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9549899 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
10MG/ML (10MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
10MG/ML (10MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
2MG/ML (2MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
2MG/ML (2MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
4MG/ML (4MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
4MG/ML (4MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
5MG/ML (5MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
5MG/ML (5MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
8MG/ML (8MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
8MG/ML (8MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG/5ML | MORPHINE SULFATE | HIKMA | N022195 | March 17, 2008 | RX | SOLUTION | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
20MG/5ML | MORPHINE SULFATE | HIKMA | N022195 | March 17, 2008 | RX | SOLUTION | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
15MG | MORPHINE SULFATE | HIKMA | N022207 | March 17, 2008 | RX | TABLET | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
30MG | MORPHINE SULFATE | HIKMA | N022207 | March 17, 2008 | RX | TABLET | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | EC50 | 7.86 | WOMBAT-PK | CHEMBL | |||
Kappa-type opioid receptor | GPCR | Ki | 6.97 | WOMBAT-PK | |||||
Delta-type opioid receptor | GPCR | Ki | 6.62 | WOMBAT-PK | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.55 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.11 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 8.92 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.06 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 7 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 8.74 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.62 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.57 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 6.52 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.30 | CHEMBL | |||||
Nociceptin receptor | GPCR | Ki | 7.86 | CHEMBL | |||||
Opioid receptor | GPCR | Ki | 8.22 | CHEMBL | |||||
Dopamine receptor | GPCR | IC50 | 8.27 | CHEMBL | |||||
Opioid receptor | GPCR | IC50 | 7.57 | CHEMBL | |||||
Mu opioid receptor-like OR2 | GPCR | Ki | 6.73 | CHEMBL | |||||
Opioid receptor, delta 1b | GPCR | Ki | 5.85 | CHEMBL | |||||
Opioid receptor homologue | GPCR | Ki | 6.65 | CHEMBL |
ID | Source |
---|---|
D00842 | KEGG_DRUG |
52-26-6 | SECONDARY_CAS_RN |
6211-15-0 | SECONDARY_CAS_RN |
4017470 | VANDF |
4017530 | VANDF |
C0026549 | UMLSCUI |
CHEBI:17303 | CHEBI |
MOI | PDB_CHEM_ID |
CHEMBL70 | ChEMBL_ID |
CHEMBL556578 | ChEMBL_ID |
DB00295 | DRUGBANK_ID |
CHEMBL2103744 | ChEMBL_ID |
CHEMBL2096625 | ChEMBL_ID |
D009020 | MESH_DESCRIPTOR_UI |
5288826 | PUBCHEM_CID |
1627 | IUPHAR_LIGAND_ID |
76I7G6D29C | UNII |
235751 | RXNORM |
15239 | MMSL |
18643 | MMSL |
1913 | MMSL |
5136 | MMSL |
d00308 | MMSL |
d05295 | MMSL |
001545 | NDDF |
001546 | NDDF |
003523 | NDDF |
373529000 | SNOMEDCT_US |
395804007 | SNOMEDCT_US |
60886004 | SNOMEDCT_US |
73572009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6011 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6012 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6013 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6014 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6015 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6016 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6017 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6018 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6019 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | NDA | 34 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0235 | TABLET | 15 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0236 | TABLET | 30 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0237 | SOLUTION | 10 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0237 | SOLUTION | 10 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0238 | SOLUTION | 20 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0238 | SOLUTION | 20 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0404 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0404 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0517 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0517 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1277 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1278 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1279 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1280 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1281 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1282 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1479 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0825 | SOLUTION | 100 mg | ORAL | ANDA | 34 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0904 | SOLUTION | 10 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0904 | SOLUTION | 10 mg | ORAL | NDA | 32 sections |
Morphine sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-3090 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 33 sections |