morphine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor antagonists/agonists, morphinan derivates 1845 57-27-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • morphine hydrochloride
  • morphine
  • morphin
  • morphina
  • morphine sulfate
  • morphine liposomal
  • morphine sulfate hydrate
  • morphine HCl
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
  • Molecular weight: 285.34
  • Formula: C17H19NO3
  • CLOGP: 0.57
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 52.93
  • ALOGS: -1.45
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O
30 mg P
30 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 57.14 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 4 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.85 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 24 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 26 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.65 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.666 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.622 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 5.598 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 28.184 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 80.220 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 85.170 % High 1
herg hERG pIC50 4.386 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.981 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.516 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 80.440 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 57
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6,MAP3K14,TEK 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.999 High 1
mh-clint Mouse hepatocyte intrinsic clearance 109.901 High 1
mppb Mouse plasma protein binding (% unbound) 73.990 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.370 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 86.640 % High 1
rh-clint Rat hepatocyte intrinsic clearance 104.713 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 89 % High 1
rppb Rat plasma protein binding (% unbound) 72.450 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 986.279 uM High 1

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 5427.86 9.44 7207 298142 456402 89866696
Drug abuse 1173.23 9.44 1417 303932 80930 90242168
Toxicity to various agents 1033.09 9.44 2694 302655 285152 90037946
Respiratory depression 582.68 9.44 456 304893 15119 90307979
Overdose 551.52 9.44 1463 303886 156246 90166852
Depressed level of consciousness 537.10 9.44 916 304433 71868 90251230
Constipation 479.44 9.44 2043 303306 278352 90044746
Sedation 475.71 9.44 693 304656 47478 90275620
Death 471.21 9.44 2886 302463 453665 89869433
Sedation complication 401.37 9.44 382 304967 16562 90306536
Respiratory arrest 388.26 9.44 519 304830 32792 90290306
Creatinine renal clearance decreased 387.94 9.44 394 304955 18505 90304593
Miosis 336.13 9.44 269 305080 9215 90313883
Drug dependence 329.72 9.44 449 304900 28878 90294220
Accidental overdose 319.59 9.44 434 304915 27839 90295259
Completed suicide 298.16 9.44 1120 304229 143938 90179160
Blood calcium decreased 296.20 9.44 433 304916 29749 90293349
Somnolence 292.76 9.44 1437 303912 207647 90115451
Coma 290.28 9.44 709 304640 71923 90251175
Alopecia 277.03 9.44 806 304543 494265 89828833
Systemic lupus erythematosus 265.61 9.44 510 304839 361386 89961712
Bradypnoea 260.34 9.44 174 305175 4484 90318614
Orthostatic hypotension 237.22 9.44 470 304879 41357 90281741
Drug withdrawal syndrome 231.21 9.44 376 304973 28347 90294751
Abdominal discomfort 223.63 9.44 840 304509 476488 89846610
Substance abuse 223.51 9.44 168 305181 5238 90317860
Pemphigus 221.64 9.44 482 304867 326382 89996716
Glossodynia 217.77 9.44 475 304874 321304 90001794
Hyperaesthesia 201.43 9.44 213 305136 10489 90312609
Macular degeneration 190.93 9.44 406 304943 37564 90285534
Cardiac arrest 187.88 9.44 776 304573 104159 90218939
Cardio-respiratory arrest 183.45 9.44 548 304801 62592 90260506
Maternal exposure during delivery 182.74 9.44 130 305219 3716 90319382
Intentional product misuse 178.38 9.44 685 304664 88919 90234179
Vomiting 175.14 9.44 3672 301677 784621 89538477
Hypotension 174.44 9.44 1769 303580 323628 89999470
Swelling 173.31 9.44 774 304575 418284 89904814
Arthropathy 167.86 9.44 650 304699 365592 89957506
Retinitis 162.85 9.44 384 304965 38074 90285024
Contrast media allergy 160.06 9.44 110 305239 2971 90320127
Hand deformity 158.00 9.44 493 304856 295869 90027229
Respiratory rate decreased 156.33 9.44 120 305229 3863 90319235
Folliculitis 155.96 9.44 281 305068 204072 90119026
Product dose omission issue 152.14 9.44 490 304859 291197 90031901
Cognitive disorder 150.99 9.44 546 304803 68861 90254237
Joint dislocation 146.03 9.44 404 304945 44178 90278920
COVID-19 144.88 9.44 215 305134 168628 90154470
Gangrene 143.00 9.44 196 305153 12680 90310418
Unresponsive to stimuli 142.67 9.44 363 304986 37758 90285340
Balance disorder 137.71 9.44 670 304679 96410 90226688
Temperature regulation disorder 137.05 9.44 205 305144 14374 90308724
Arthralgia 134.88 9.44 1831 303518 776691 89546407
Anterior spinal artery syndrome 132.45 9.44 42 305307 157 90322941
Personality disorder 128.62 9.44 183 305166 12261 90310837
Inadequate analgesia 126.25 9.44 97 305252 3127 90319971
Ill-defined disorder 125.75 9.44 272 305077 184619 90138479
Drug ineffective 125.70 9.44 3631 301718 1380667 88942431
Arterial occlusive disease 121.30 9.44 178 305171 12268 90310830
Myoclonus 120.46 9.44 225 305124 18943 90304155
Pericarditis 120.18 9.44 485 304864 269666 90053432
Duodenal ulcer perforation 117.97 9.44 368 304981 220920 90102178
Injection site reaction 117.89 9.44 83 305266 91997 90231101
Device expulsion 116.20 9.44 5 305344 40881 90282217
Food allergy 111.81 9.44 258 305091 25220 90297878
Arthritis 110.30 9.44 951 304398 166364 90156734
Neurologic neglect syndrome 109.50 9.44 142 305207 8705 90314393
Bone erosion 108.52 9.44 409 304940 52612 90270486
Injection site erythema 108.45 9.44 103 305246 98399 90224699
Exposure via ingestion 108.30 9.44 82 305267 2585 90320513
Carotid artery thrombosis 107.98 9.44 143 305206 8949 90314149
Delirium 107.38 9.44 660 304689 103699 90219399
Maternal exposure during pregnancy 107.22 9.44 741 304608 359322 89963776
Helicobacter infection 106.83 9.44 398 304951 226452 90096646
Injection site pain 106.53 9.44 270 305079 173429 90149669
Poisoning 106.28 9.44 187 305162 15030 90308068
Irritable bowel syndrome 105.69 9.44 352 304997 207096 90116002
Intestinal pseudo-obstruction 104.92 9.44 59 305290 1104 90321994
Anti-cyclic citrullinated peptide antibody positive 104.19 9.44 426 304923 236007 90087091
Blepharospasm 103.83 9.44 29 305320 55416 90267682
Foetal death 102.35 9.44 220 305129 20503 90302595
Asphyxia 102.30 9.44 123 305226 6980 90316118
Hypoxia 101.47 9.44 498 304851 71901 90251197
Impaired healing 101.31 9.44 425 304924 233774 90089324
Sensory loss 99.94 9.44 201 305148 17874 90305224
Fatigue 98.56 9.44 3051 302298 1150972 89172126
Seronegative arthritis 97.54 9.44 200 305149 18034 90305064
Drug abuser 96.82 9.44 77 305272 2613 90320485
Exostosis 95.90 9.44 394 304955 52740 90270358
Hepatic cirrhosis 95.83 9.44 445 304904 62808 90260290
Muscle injury 93.98 9.44 294 305055 176360 90146738
Weight increased 93.95 9.44 927 304422 417000 89906098
Laryngitis 93.71 9.44 379 304970 50374 90272724
Poisoning deliberate 93.16 9.44 185 305164 16301 90306797
Condition aggravated 93.03 9.44 1429 303920 594116 89728982
Adjustment disorder 92.67 9.44 137 305212 9505 90313593
Apnoea 92.27 9.44 135 305214 9279 90313819
Lupus-like syndrome 91.18 9.44 366 304983 48480 90274618
Product quality issue 90.83 9.44 80 305269 79245 90243853
White blood cell count abnormal 90.63 9.44 119 305230 7385 90315713
Wound 89.94 9.44 624 304725 302356 90020742
Off label use 89.76 9.44 2932 302417 1099320 89223778
Upper respiratory tract infection 89.67 9.44 739 304610 127579 90195519
Rash 89.05 9.44 2024 303325 794076 89529022
Nausea 88.93 9.44 4580 300769 1105736 89217362
Nail disorder 88.65 9.44 44 305305 59023 90264075
Foot deformity 86.96 9.44 415 304934 59236 90263862
Drug diversion 86.10 9.44 50 305299 997 90322101
Blister 86.01 9.44 505 304844 254493 90068605
Onychomadesis 84.40 9.44 25 305324 45973 90277125
Hemiplegia 83.79 9.44 175 305174 15985 90307113
Soft tissue disorder 83.62 9.44 87 305262 4203 90318895
Mental status changes 82.77 9.44 334 305015 44345 90278753
Hallucination 82.17 9.44 439 304910 65520 90257578
Withdrawal syndrome 81.71 9.44 212 305137 22312 90300786
Onychomycosis 81.20 9.44 14 305335 37362 90285736
Drug use disorder 80.84 9.44 119 305230 8224 90314874
Psoriatic arthropathy 80.34 9.44 446 304903 227889 90095209
Abortion spontaneous 78.54 9.44 42 305307 54014 90269084
Intentional product use issue 78.31 9.44 420 304929 216472 90106626
Acute chest syndrome 76.76 9.44 48 305301 1100 90321998
Contraindicated product administered 75.77 9.44 701 304648 319438 90003660
Gastrooesophageal reflux disease 75.59 9.44 296 305053 166041 90157057
Taste disorder 75.51 9.44 58 305291 61488 90261610
Injection site swelling 75.20 9.44 55 305294 59784 90263314
Lupus vulgaris 75.01 9.44 326 305023 44733 90278365
Psoriasis 73.71 9.44 792 304557 146962 90176136
Injection site pruritus 73.68 9.44 45 305304 53789 90269309
Therapeutic product effect decreased 73.62 9.44 590 304759 276981 90046117
Drug screen positive 72.89 9.44 76 305273 3681 90319417
Hyperhidrosis 72.88 9.44 741 304608 135564 90187534
Sphincter of Oddi dysfunction 72.83 9.44 34 305315 422 90322676
Radiculopathy 72.15 9.44 179 305170 18326 90304772
Stomatitis 71.89 9.44 586 304763 274112 90048986
Vaginal flatulence 71.63 9.44 142 305207 12496 90310602
Epilepsy 71.15 9.44 104 305245 82102 90240996
Female genital tract fistula 70.90 9.44 174 305175 17694 90305404
Immunodeficiency 69.09 9.44 309 305040 42925 90280173
Respiratory failure 68.79 9.44 655 304694 117763 90205335
Motor dysfunction 66.70 9.44 178 305171 19052 90304046
Peripheral swelling 66.56 9.44 985 304364 412121 89910977
Malignant neoplasm progression 66.54 9.44 600 304749 106270 90216828
Coordination abnormal 66.47 9.44 190 305159 21166 90301932
Gastrointestinal disorder 65.61 9.44 551 304798 256136 90066962
Diarrhoea 65.20 9.44 2547 302802 936643 89386455
Aspiration 64.60 9.44 155 305194 15538 90307560
Urinary retention 62.76 9.44 273 305076 37471 90285627
Discomfort 62.64 9.44 606 304743 273729 90049369
Proctitis 62.04 9.44 150 305199 15109 90307989
Abdominal pain 62.00 9.44 1759 303590 393962 89929136
No adverse event 61.83 9.44 83 305266 67899 90255199
Therapy interrupted 61.75 9.44 47 305302 50061 90273037
Dilatation intrahepatic duct acquired 61.37 9.44 36 305313 732 90322366
Synovitis 61.12 9.44 764 304585 328988 89994110
Drug withdrawal syndrome neonatal 60.15 9.44 55 305294 2264 90320834
Hospitalisation 60.11 9.44 225 305124 127875 90195223
Hypercapnia 60.08 9.44 92 305257 6585 90316513
Nasal congestion 59.82 9.44 119 305230 83295 90239803
Nasopharyngitis 59.08 9.44 990 304359 406114 89916984
Finger deformity 58.34 9.44 19 305330 32878 90290220
Muscle spasticity 57.61 9.44 254 305095 35068 90288030
Affect lability 57.48 9.44 162 305187 17901 90305197
Obliterative bronchiolitis 57.04 9.44 57 305292 2624 90320474
Respiratory acidosis 56.99 9.44 100 305249 8019 90315079
Neutropenic sepsis 55.17 9.44 160 305189 17970 90305128
Lethargy 53.23 9.44 380 304969 62759 90260339
Joint stiffness 53.19 9.44 447 304902 77595 90245503
Tachycardia 52.87 9.44 785 304564 156888 90166210
Vaginal discharge 52.84 9.44 165 305184 19299 90303799
Anti-cyclic citrullinated peptide antibody 51.62 9.44 205 305144 27016 90296082
Prescribed overdose 51.35 9.44 529 304820 97096 90226002
Myelosuppression 51.25 9.44 63 305286 53528 90269570
Red blood cell sedimentation rate increased 51.05 9.44 463 304886 82132 90240966
Back injury 51.02 9.44 49 305300 46573 90276525
Acidosis 50.51 9.44 124 305225 12612 90310486
Dry skin 49.39 9.44 143 305206 87930 90235168
Skin haemorrhage 48.88 9.44 171 305178 21209 90301889
Cardiac failure congestive 48.51 9.44 170 305179 98524 90224574
Product dose omission in error 48.43 9.44 6 305343 20497 90302601
Adverse reaction 47.91 9.44 20 305329 29692 90293406
Hemiparesis 47.56 9.44 223 305126 31596 90291502
Grip strength 47.55 9.44 98 305251 8867 90314231
Narcotic bowel syndrome 47.17 9.44 18 305331 129 90322969
Visceral congestion 47.03 9.44 24 305325 366 90322732
Osteoporosis 47.00 9.44 515 304834 96016 90227082
Cholestasis 46.85 9.44 244 305105 36055 90287043
Bronchopulmonary aspergillosis allergic 45.91 9.44 60 305289 3706 90319392
Sinusitis 45.40 9.44 848 304501 342240 89980858
Injection site rash 44.60 9.44 13 305336 24160 90298938
Product label confusion 44.59 9.44 11 305338 22839 90300259
Dysarthria 44.26 9.44 325 305024 54157 90268941
Lower respiratory tract infection 44.12 9.44 587 304762 250072 90073026
Total lung capacity decreased 44.01 9.44 59 305290 3736 90319362
Sleep disorder due to general medical condition, insomnia type 43.82 9.44 254 305095 128440 90194658
Rhythm idioventricular 43.66 9.44 23 305326 376 90322722
Colitis 43.18 9.44 392 304957 69550 90253548
Spondylitis 43.02 9.44 125 305224 14053 90309045
Oral candidiasis 42.81 9.44 234 305115 35221 90287877
Pleuritic pain 42.71 9.44 103 305246 10358 90312740
Contusion 41.81 9.44 595 304754 250621 90072477
Brain oedema 41.45 9.44 141 305208 17244 90305854
Colorectal cancer metastatic 41.03 9.44 29 305320 820 90322278
Sleep disorder 40.85 9.44 448 304901 197582 90125516
Tonsillar disorder 40.28 9.44 33 305316 1169 90321929
Product use in unapproved indication 39.98 9.44 846 304503 335390 89987708
Eating disorder 39.96 9.44 194 305155 27879 90295219
Creatinine renal clearance increased 39.57 9.44 52 305297 3229 90319869
Anaphylactic reaction 39.46 9.44 460 304889 87064 90236034
Accidental death 38.97 9.44 41 305308 2007 90321091
Dyspnoea exertional 38.64 9.44 120 305229 72168 90250930
Mobility decreased 37.97 9.44 1110 304239 249624 90073474
Visual impairment 37.94 9.44 642 304707 131723 90191375
Colitis ulcerative 37.83 9.44 339 305010 59927 90263171
Suspected suicide 37.78 9.44 93 305256 9475 90313623
Frequent bowel movements 37.68 9.44 324 305025 56611 90266487
Dermatitis atopic 37.52 9.44 16 305333 23456 90299642
Anxiety 37.46 9.44 1335 304014 308437 90014661
Joint swelling 37.43 9.44 1353 303996 501947 89821151
Rectal haemorrhage 37.36 9.44 435 304914 82309 90240789
Full blood count abnormal 37.17 9.44 41 305308 36556 90286542
Sternal fracture 36.77 9.44 47 305302 2840 90320258
Heavy menstrual bleeding 36.16 9.44 12 305337 20518 90302580
Angina pectoris 36.15 9.44 241 305108 38919 90284179
Dysphagia 36.08 9.44 555 304794 111723 90211375
Suicide attempt 35.64 9.44 132 305217 75267 90247831
Oedema peripheral 35.10 9.44 1127 304222 256788 90066310
Chronic sinusitis 34.98 9.44 166 305183 23636 90299462
Walking aid user 34.91 9.44 222 305127 35284 90287814
Night sweats 34.90 9.44 272 305077 128494 90194604
Encephalopathy 34.88 9.44 272 305077 46172 90276926
Dyspnoea 34.70 9.44 2528 302821 878427 89444671
Plasma cell myeloma 34.57 9.44 246 305103 40582 90282516
Aphasia 34.55 9.44 255 305094 42557 90280541
Sepsis 34.43 9.44 821 304528 178993 90144105
Foetal megacystis 34.24 9.44 10 305339 26 90323072
Spinal cord injury 34.16 9.44 29 305320 1080 90322018
Facet joint syndrome 34.13 9.44 193 305156 98196 90224902
Gait inability 34.04 9.44 322 305027 146134 90176964
Lung opacity 33.91 9.44 68 305281 6034 90317064
Ear infection 33.84 9.44 372 304977 69403 90253695
Device programming error 33.74 9.44 17 305332 252 90322846
Procedural pain 33.68 9.44 210 305139 33150 90289948
Agitation 33.59 9.44 360 304989 66738 90256360
Accidental exposure to product by child 33.38 9.44 31 305318 1302 90321796
Libido increased 33.33 9.44 35 305314 1709 90321389
Iodine allergy 33.26 9.44 26 305323 860 90322238
Dry eye 33.26 9.44 93 305256 57838 90265260
Sopor 33.17 9.44 21 305328 24623 90298475
Ventilation perfusion mismatch 32.81 9.44 22 305327 570 90322528
Accidental exposure to product 32.52 9.44 58 305291 42308 90280790
Vascular malformation 32.50 9.44 24 305325 728 90322370
Spinal fusion surgery 32.31 9.44 103 305246 12180 90310918
Angioedema 31.98 9.44 347 305002 64529 90258569
Respiratory tract infection 31.62 9.44 98 305251 58980 90264118
Schizophrenia 31.50 9.44 6 305343 14908 90308190
Terminal state 31.45 9.44 43 305306 2775 90320323
Pancreatic fibrosis 31.45 9.44 12 305337 86 90323012
Paranasal cyst 30.91 9.44 24 305325 786 90322312
Toxicologic test abnormal 30.82 9.44 23 305326 709 90322389
Inflammation 30.77 9.44 420 304929 178172 90144926
Colitis microscopic 30.66 9.44 95 305254 11064 90312034
Transient ischaemic attack 30.61 9.44 62 305287 43114 90279984
Inappropriate schedule of product administration 30.59 9.44 340 305009 149593 90173505
Paraesthesia oral 30.54 9.44 197 305152 31462 90291636
Hallucination, visual 30.34 9.44 156 305193 22936 90300162
Pulseless electrical activity 30.30 9.44 82 305267 8850 90314248
Paraesthesia 30.28 9.44 628 304721 249698 90073400
Eye pain 29.99 9.44 65 305284 44103 90278995
Antinuclear antibody negative 29.92 9.44 16 305333 270 90322828
Migraine 29.91 9.44 456 304893 189936 90133162
Dizziness 29.90 9.44 1652 303697 587632 89735466
Skin candida 29.87 9.44 33 305316 1708 90321390
Nervous system disorder 29.86 9.44 148 305201 21445 90301653
Progressive multifocal leukoencephalopathy 29.66 9.44 8 305341 15647 90307451
Muscle spasms 29.56 9.44 635 304714 251248 90071850
Femur fracture 29.51 9.44 70 305279 46012 90277086
Injection site urticaria 29.24 9.44 12 305337 17999 90305099
Thrombocytopenia 29.16 9.44 915 304434 207810 90115288
Implant site extravasation 28.94 9.44 20 305329 545 90322553
Hostility 28.94 9.44 37 305312 2236 90320862
Systemic mastocytosis 28.88 9.44 14 305335 190 90322908
Post procedural complication 28.86 9.44 134 305215 18908 90304190
Catheter site granuloma 28.84 9.44 8 305341 16 90323082
Intentional self-injury 28.56 9.44 34 305315 29300 90293798
Oxygen saturation decreased 28.53 9.44 515 304834 106968 90216130
Disease recurrence 28.50 9.44 52 305297 37601 90285497
Wrong technique in product usage process 28.43 9.44 134 305215 71437 90251661
Incoherent 28.30 9.44 56 305293 4921 90318177
Soft tissue injury 28.14 9.44 35 305314 2057 90321041
Pruritus allergic 28.05 9.44 32 305317 1716 90321382
Back pain 28.01 9.44 1322 304027 315853 90007245
Pancreatitis 28.01 9.44 359 304990 69467 90253631
Device difficult to use 27.93 9.44 12 305337 17513 90305585
Multiple sclerosis relapse 27.83 9.44 87 305262 52218 90270880
Diffuse axonal injury 27.79 9.44 11 305338 88 90323010
Neutropenia 27.56 9.44 563 304786 224341 90098757
Lip dry 27.47 9.44 213 305136 100742 90222356
Respiratory tract congestion 27.33 9.44 172 305177 27238 90295860
Injection site bruising 27.13 9.44 88 305261 52219 90270879
Neuroblastoma recurrent 27.11 9.44 13 305336 172 90322926
Theft 27.06 9.44 11 305338 95 90323003
Hepatic function abnormal 26.80 9.44 74 305275 46214 90276884
Uveitis 26.80 9.44 10 305339 15893 90307205
Cyanosis 26.66 9.44 133 305216 19322 90303776
Spinal epidural haemorrhage 26.43 9.44 15 305334 286 90322812
Therapy non-responder 26.33 9.44 314 305035 136390 90186708
Alveolitis 26.31 9.44 41 305308 2980 90320118
Skin reaction 26.26 9.44 128 305221 18425 90304673
Disorientation 26.10 9.44 245 305104 43869 90279229
Bradycardia 25.99 9.44 412 304937 83435 90239663
Respiratory distress 25.96 9.44 222 305127 38724 90284374
Rhinitis allergic 25.95 9.44 12 305337 16773 90306325
Decreased immune responsiveness 25.47 9.44 76 305273 8672 90314426
Type 2 diabetes mellitus 25.43 9.44 507 304842 202737 90120361
Myelodysplastic syndrome 25.25 9.44 20 305329 20883 90302215
Joint effusion 24.91 9.44 18 305331 19692 90303406
Nodule 24.86 9.44 32 305317 26654 90296444
Eye pruritus 24.84 9.44 37 305312 28990 90294108
Product selection error 24.66 9.44 14 305335 267 90322831
Blood calcium increased 24.65 9.44 93 305256 11965 90311133
Liver injury 24.63 9.44 415 304934 170152 90152946
Post-traumatic neck syndrome 24.56 9.44 36 305313 2478 90320620
Substance use disorder 24.34 9.44 32 305317 1988 90321110
Confusional state 24.29 9.44 1560 303789 384645 89938453
Polyarthritis 24.20 9.44 16 305333 18334 90304764
Peripheral nerve injury 24.16 9.44 20 305329 719 90322379
Hypothermia 23.90 9.44 110 305239 15465 90307633
Dislocation of vertebra 23.84 9.44 291 305058 55677 90267421
Chronic spontaneous urticaria 23.76 9.44 30 305319 1790 90321308
White blood cell count decreased 23.67 9.44 408 304941 166701 90156397
Hepatic enzyme increased 23.67 9.44 984 304365 359752 89963346
Sinus congestion 23.66 9.44 166 305183 27258 90295840
Sneezing 23.59 9.44 177 305172 29692 90293406
Hypoxic-ischaemic encephalopathy 23.56 9.44 50 305299 4618 90318480
Drug interaction 23.50 9.44 1148 304201 275305 90047793
Therapy cessation 23.47 9.44 55 305294 36306 90286792
Prescribed underdose 23.40 9.44 369 304980 74650 90248448
Exposure via skin contact 23.27 9.44 4 305345 10701 90312397
Cough 23.25 9.44 1011 304338 367951 89955147
Coronary artery disease 23.23 9.44 49 305300 33574 90289524
Pneumonia viral 23.22 9.44 74 305275 8749 90314349
Epidural haemorrhage 23.22 9.44 14 305335 300 90322798
Swollen tongue 23.20 9.44 247 305102 45709 90277389
Throat irritation 23.18 9.44 85 305264 48610 90274488
Atrial fibrillation 23.09 9.44 314 305035 133297 90189801
Pancreatic neuroendocrine tumour metastatic 23.07 9.44 9 305340 69 90323029
Abdominal pain upper 22.99 9.44 902 304447 331772 89991326
Interstitial lung disease 22.81 9.44 157 305192 76248 90246850
Substance use 22.81 9.44 24 305325 1175 90321923
Implant site discharge 22.78 9.44 11 305338 148 90322950
Anaesthesia 22.78 9.44 16 305333 448 90322650
Rheumatic fever 22.61 9.44 371 304978 152750 90170348
Foetal monitoring abnormal 22.58 9.44 13 305336 255 90322843
Pulmonary fibrosis 22.48 9.44 497 304852 107006 90216092
Breast cancer female 22.47 9.44 11 305338 14875 90308223
Cardiac failure 22.45 9.44 248 305101 109248 90213850
Breast cancer 22.34 9.44 99 305250 53662 90269436
Cardiac output decreased 22.28 9.44 22 305327 998 90322100
Feeling jittery 22.24 9.44 12 305337 15359 90307739
Drug resistance 22.21 9.44 43 305306 30406 90292692
Eczema 22.19 9.44 97 305252 52773 90270325
Mucosal inflammation 22.16 9.44 294 305055 57331 90265767
Syncope 22.13 9.44 314 305035 132349 90190749
Coombs positive haemolytic anaemia 21.99 9.44 16 305333 474 90322624
Pulmonary oedema 21.95 9.44 312 305037 61768 90261330
Ocular hyperaemia 21.91 9.44 51 305298 33747 90289351
Breast cancer metastatic 21.85 9.44 105 305244 15027 90308071
Excessive eye blinking 21.82 9.44 25 305324 1347 90321751
Clonus 21.77 9.44 55 305294 5695 90317403
Complex regional pain syndrome 21.66 9.44 35 305314 2624 90320474
Neurotoxicity 21.58 9.44 135 305214 21332 90301766
Intentional dose omission 21.50 9.44 17 305332 17766 90305332
Eye irritation 21.45 9.44 52 305297 33926 90289172
Hepatocellular injury 21.42 9.44 169 305180 28789 90294309
Injection site discolouration 21.36 9.44 3 305346 9317 90313781
Dry mouth 21.30 9.44 465 304884 183594 90139504
Myalgia 21.27 9.44 439 304910 174686 90148412
Ulcer haemorrhage 21.15 9.44 35 305314 26286 90296812
Neck pain 21.10 9.44 264 305085 113699 90209399
Vascular device infection 21.07 9.44 88 305261 11864 90311234
Gallbladder cholesterolosis 21.05 9.44 19 305330 769 90322329
Mastoiditis 20.97 9.44 27 305322 1643 90321455
Anaesthetic complication 20.83 9.44 33 305316 2432 90320666
Drug tolerance decreased 20.82 9.44 182 305167 31948 90291150
Vascular resistance systemic decreased 20.81 9.44 10 305339 133 90322965
Dependence 20.47 9.44 30 305319 2065 90321033
Device issue 20.44 9.44 43 305306 29494 90293604
Allodynia 20.38 9.44 21 305328 1003 90322095
Impaired work ability 20.35 9.44 21 305328 19305 90303793
Urinary bladder rupture 20.34 9.44 11 305338 190 90322908
Surgery 20.30 9.44 80 305269 44807 90278291
Impaired quality of life 20.30 9.44 29 305320 23115 90299983
Aspiration bone marrow 20.24 9.44 11 305338 192 90322906
Product storage error 20.20 9.44 23 305326 20218 90302880
Prescription drug used without a prescription 20.19 9.44 38 305311 3217 90319881
Cancer pain 20.18 9.44 43 305306 3982 90319116
Tenosynovitis 20.18 9.44 12 305337 14555 90308543
Pupillary reflex impaired 20.05 9.44 33 305316 2512 90320586
Metastases to eye 19.94 9.44 11 305338 198 90322900
Transplant rejection 19.91 9.44 9 305340 12749 90310349
Blood immunoglobulin A decreased 19.91 9.44 27 305322 1729 90321369
Obstructive defaecation 19.87 9.44 12 305337 258 90322840
Pulmonary toxicity 19.86 9.44 7 305342 11524 90311574
Congenital coronary artery malformation 19.80 9.44 10 305339 149 90322949
Small intestinal obstruction 19.79 9.44 131 305218 21103 90301995
Hypoacusis 19.73 9.44 40 305309 27810 90295288
Breakthrough pain 19.67 9.44 24 305325 1383 90321715
Foetal heart rate abnormal 19.64 9.44 20 305329 942 90322156
Adjustment disorder with depressed mood 19.57 9.44 284 305065 56469 90266629
Tendonitis 19.53 9.44 26 305323 21346 90301752
Genital haemorrhage 19.48 9.44 3 305346 8699 90314399
Musculoskeletal toxicity 19.45 9.44 16 305333 570 90322528
Administration site abscess 19.45 9.44 6 305343 20 90323078
Administration site induration 19.45 9.44 6 305343 20 90323078
Tinnitus 19.38 9.44 77 305272 43025 90280073
Porphyria acute 19.31 9.44 115 305234 17860 90305238
Treatment failure 19.31 9.44 832 304517 303096 90020002
Stoma site dermatitis 19.23 9.44 12 305337 274 90322824
Product administration interrupted 19.21 9.44 9 305340 12483 90310615
Abortion induced 19.17 9.44 8 305341 11880 90311218
Infant irritability 19.13 9.44 5 305344 7 90323091
C-reactive protein 19.03 9.44 49 305300 31318 90291780
Antinuclear antibody positive 18.93 9.44 4 305345 9237 90313861
Muscle twitching 18.88 9.44 143 305206 24059 90299039
COVID-19 pneumonia 18.86 9.44 20 305329 18157 90304941
Blood cholesterol increased 18.82 9.44 545 304804 207467 90115631
Pulmonary congestion 18.79 9.44 121 305228 19312 90303786
Suspected product tampering 18.79 9.44 4 305345 0 90323098
Chest wall mass 18.75 9.44 16 305333 600 90322498
Muscle tension dysphonia 18.74 9.44 12 305337 287 90322811
Urticaria thermal 18.64 9.44 15 305334 518 90322580
Hyperreflexia 18.60 9.44 57 305292 6600 90316498
Blood alkaline phosphatase abnormal 18.58 9.44 23 305326 1345 90321753
Complication of device insertion 18.55 9.44 6 305343 10430 90312668
Restlessness 18.51 9.44 193 305156 35527 90287571
Administration site discharge 18.41 9.44 6 305343 25 90323073
Hypoventilation 18.34 9.44 49 305300 5247 90317851
Joint destruction 18.33 9.44 11 305338 13276 90309822
Myocardial infarction 18.32 9.44 249 305100 105723 90217375
Scan abnormal 18.29 9.44 16 305333 621 90322477
Pregnancy 18.27 9.44 128 305221 61919 90261179
Sinus disorder 18.27 9.44 187 305162 34260 90288838
Breath sounds abnormal 18.21 9.44 101 305248 15285 90307813
Chronic kidney disease 18.20 9.44 97 305252 50094 90273004
Wheezing 18.12 9.44 638 304711 237442 90085656
Infective pulmonary exacerbation of cystic fibrosis 18.12 9.44 6 305343 10273 90312825
Intestinal obstruction 18.02 9.44 198 305151 36933 90286165
Factitious disorder 18.01 9.44 9 305340 131 90322967
Drug dose omission by device 17.98 9.44 6 305343 10225 90312873
Cardiopulmonary failure 17.92 9.44 42 305307 4146 90318952
Haematotoxicity 17.83 9.44 10 305339 12525 90310573
Pleural effusion 17.82 9.44 499 304850 111492 90211606
Cardiac murmur 17.81 9.44 21 305328 18173 90304925
Asthenia 17.80 9.44 1552 303797 532199 89790899
Upper-airway cough syndrome 17.64 9.44 15 305334 15120 90307978
Streptococcal sepsis 17.64 9.44 38 305311 3546 90319552
Spinal cord compression 17.58 9.44 46 305303 4865 90318233
Incubator therapy 17.58 9.44 7 305342 57 90323041
Skin cancer 17.54 9.44 12 305337 13507 90309591
Nasal disorder 17.48 9.44 36 305313 3256 90319842
Blood calcium abnormal 17.45 9.44 27 305322 1950 90321148
Calcium deficiency 17.45 9.44 22 305327 1311 90321787
Injection site warmth 17.37 9.44 20 305329 17495 90305603
Blood pH decreased 17.30 9.44 31 305318 2527 90320571
Central nervous system injury 17.25 9.44 9 305340 144 90322954
Gastrointestinal stoma output abnormal 17.25 9.44 13 305336 407 90322691
Blood glucose increased 17.12 9.44 222 305127 95024 90228074
Illness 17.06 9.44 185 305164 81784 90241314
Sinobronchitis 16.97 9.44 16 305333 685 90322413
Rash erythematous 16.94 9.44 311 305038 64793 90258305
Urinary tract infection 16.94 9.44 849 304500 304783 90018315
Neuroendocrine tumour of the lung 16.91 9.44 6 305343 34 90323064
Renal function test abnormal 16.86 9.44 58 305291 7133 90315965
Blood phosphorus decreased 16.86 9.44 46 305303 4988 90318110
Hallucination, tactile 16.66 9.44 13 305336 429 90322669
Spinal cord infarction 16.60 9.44 12 305337 352 90322746
Infusion site reaction 16.56 9.44 24 305325 19015 90304083
C-reactive protein abnormal 16.51 9.44 316 305033 127113 90195985
Nail bed inflammation 16.47 9.44 25 305324 1776 90321322
Myocardial fibrosis 16.46 9.44 18 305331 921 90322177
Hypopnoea 16.37 9.44 42 305307 4389 90318709
Aspergillus infection 16.33 9.44 8 305341 10815 90312283
Epidural analgesia 16.31 9.44 9 305340 162 90322936
Device dislocation 16.30 9.44 53 305296 31429 90291669
Glycosylated haemoglobin increased 16.29 9.44 17 305332 15545 90307553
Hepatitis fulminant 16.27 9.44 39 305310 3906 90319192
Faecaloma 16.25 9.44 74 305275 10357 90312741
Administration site odour 16.22 9.44 6 305343 39 90323059
Adverse event 16.20 9.44 288 305061 117130 90205968
Drug tolerance increased 16.11 9.44 10 305339 226 90322872
Mydriasis 16.10 9.44 96 305253 14916 90308182
Encephalitis toxic 16.09 9.44 6 305343 40 90323058
Basal ganglion degeneration 16.08 9.44 12 305337 370 90322728
Suicidal ideation 16.06 9.44 165 305184 73690 90249408
Pupil fixed 15.97 9.44 27 305322 2101 90320997
Gastrointestinal stoma complication 15.96 9.44 29 305320 2390 90320708
Iron deficiency anaemia 15.91 9.44 35 305314 23627 90299471
Tension headache 15.90 9.44 3 305346 7506 90315592
Neuroblastoma 15.90 9.44 7 305342 75 90323023
Nasal mucosal disorder 15.89 9.44 25 305324 1832 90321266
Keratitis 15.88 9.44 39 305310 3967 90319131
Fibromyalgia 15.87 9.44 552 304797 205717 90117381
Amenorrhoea 15.76 9.44 10 305339 11712 90311386
Product name confusion 15.62 9.44 8 305341 123 90322975
Rheumatic disorder 15.49 9.44 35 305314 3373 90319725
Oropharyngeal pain 15.43 9.44 284 305065 114903 90208195
Blood immunoglobulin M increased 15.41 9.44 21 305328 1351 90321747
Tardive dyskinesia 15.15 9.44 9 305340 10921 90312177
Pseudomonal sepsis 15.10 9.44 40 305309 4262 90318836
Cytomegalovirus infection 15.05 9.44 43 305306 26559 90296539
Myopathy 15.03 9.44 14 305335 13504 90309594
Hepatitis 14.99 9.44 159 305190 70580 90252518
Rash macular 14.98 9.44 52 305297 30228 90292870
Aplastic anaemia 14.97 9.44 86 305263 13183 90309915
Product use issue 14.88 9.44 935 304414 328984 89994114
Stoma site pain 14.88 9.44 21 305328 1396 90321702
Urinary tract stoma complication 14.84 9.44 6 305343 51 90323047
Blood alkaline phosphatase increased 14.81 9.44 236 305113 47843 90275255
Dose calculation error 14.72 9.44 11 305338 340 90322758
Sickle cell anaemia with crisis 14.69 9.44 56 305293 7241 90315857
Iron deficiency 14.66 9.44 7 305342 9605 90313493
Coma scale abnormal 14.64 9.44 47 305302 5579 90317519
Blood pressure diastolic abnormal 14.56 9.44 28 305321 19853 90303245
Pituitary apoplexy 14.50 9.44 8 305341 144 90322954
Maternal exposure before pregnancy 14.49 9.44 10 305339 11203 90311895
Red blood cell count decreased 14.46 9.44 94 305255 46257 90276841
Therapeutic response shortened 14.45 9.44 35 305314 22844 90300254
Increased bronchial secretion 14.45 9.44 26 305323 2127 90320971
Patient uncooperative 14.42 9.44 10 305339 274 90322824
Pharyngitis streptococcal 14.40 9.44 13 305336 12729 90310369
Metastases to spine 14.37 9.44 36 305313 3707 90319391
Toxic leukoencephalopathy 14.35 9.44 16 305333 837 90322261
Hypomania 14.33 9.44 6 305343 8891 90314207
Sinus tachycardia 14.28 9.44 153 305196 28360 90294738
Metastases to bone 14.27 9.44 140 305209 25365 90297733
Mitochondrial encephalomyopathy 14.25 9.44 7 305342 98 90323000
Flushing 14.21 9.44 211 305138 88280 90234818
Infusion site granuloma 14.09 9.44 3 305346 0 90323098
Visual analogue scale 14.09 9.44 3 305346 0 90323098
Rhinitis 14.01 9.44 15 305334 13557 90309541
Peripheral venous disease 13.86 9.44 199 305150 83722 90239376
Pruritus 13.85 9.44 1605 303744 539920 89783178
Central pain syndrome 13.81 9.44 14 305335 656 90322442
Squamous cell carcinoma of skin 13.75 9.44 4 305345 7445 90315653
Exposure during pregnancy 13.72 9.44 956 304393 237454 90085644
Menstruation irregular 13.70 9.44 5 305344 8055 90315043
Autoimmune hepatitis 13.69 9.44 9 305340 10342 90312756
Vomiting projectile 13.64 9.44 23 305326 1786 90321312
Neuropathy peripheral 13.64 9.44 354 304995 136616 90186482
Infusion 13.62 9.44 8 305341 163 90322935
Hiatus hernia 13.62 9.44 42 305307 25319 90297779
Tubulointerstitial nephritis 13.59 9.44 42 305307 25301 90297797
Spinal cord paralysis 13.58 9.44 5 305344 32 90323066
Eosinophil cationic protein increased 13.57 9.44 6 305343 65 90323033
Obesity 13.55 9.44 262 305087 105245 90217853
Abnormal behaviour 13.55 9.44 126 305223 22502 90300596
Blood albumin abnormal 13.53 9.44 18 305331 1131 90321967
Eye swelling 13.53 9.44 52 305297 29334 90293764
Neuralgia 13.51 9.44 164 305185 31336 90291762
Cardiomyopathy 13.50 9.44 30 305319 20176 90302922
Osteolysis 13.48 9.44 34 305315 3516 90319582
Immunisation reaction 13.44 9.44 15 305334 785 90322313
Infusion site pain 13.44 9.44 29 305320 19709 90303389
Compression fracture 13.43 9.44 62 305287 8727 90314371
Administration site haemorrhage 13.33 9.44 6 305343 68 90323030
Congenital knee dislocation 13.28 9.44 4 305345 12 90323086
5-hydroxyindolacetic acid 13.28 9.44 4 305345 12 90323086
PO2 decreased 13.14 9.44 21 305328 1560 90321538
Hypohidrosis 13.11 9.44 6 305343 71 90323027
Weight decreased 13.10 9.44 1467 303882 378443 89944655
Thymus disorder 13.08 9.44 10 305339 320 90322778
Documented hypersensitivity to administered product 13.06 9.44 14 305335 700 90322398
Mitral valve incompetence 13.04 9.44 36 305313 22488 90300610
Injection site mass 13.02 9.44 35 305314 22055 90301043
Bone marrow failure 12.99 9.44 60 305289 32161 90290937
Pain assessment 12.97 9.44 5 305344 37 90323061
Arterial thrombosis 12.95 9.44 21 305328 1579 90321519
Liver function test abnormal 12.92 9.44 242 305107 50603 90272495
Incorrect route of product administration 12.88 9.44 241 305108 50385 90272713
Gastrointestinal tube insertion 12.82 9.44 19 305330 1321 90321777
5-hydroxyindolacetic acid in urine 12.82 9.44 4 305345 14 90323084
Fear-related avoidance of activities 12.81 9.44 8 305341 183 90322915
Congenital pulmonary hypertension 12.79 9.44 7 305342 124 90322974
Herpes simplex viraemia 12.75 9.44 11 305338 419 90322679
Liver disorder 12.73 9.44 311 305038 120958 90202140
Non-small cell lung cancer 12.70 9.44 38 305311 4343 90318755
Injection site induration 12.67 9.44 10 305339 10458 90312640
Fat embolism 12.63 9.44 10 305339 337 90322761
Postoperative ileus 12.60 9.44 13 305336 622 90322476
Renal impairment 12.58 9.44 265 305084 105156 90217942
Weaning failure 12.57 9.44 12 305337 522 90322576
Rhinorrhoea 12.55 9.44 388 304961 87928 90235170
Road traffic accident 12.54 9.44 462 304887 107164 90215934
Occupational dermatitis 12.52 9.44 5 305344 41 90323057
Infrequent bowel movements 12.43 9.44 20 305329 1494 90321604
Piloerection 12.41 9.44 13 305336 633 90322465
Myoglobin urine 12.40 9.44 4 305345 16 90323082
Phyllodes tumour 12.34 9.44 6 305343 82 90323016
Hypoaldosteronism 12.33 9.44 10 305339 349 90322749
Musculoskeletal pain 12.33 9.44 462 304887 170789 90152309
Neuromuscular block prolonged 12.31 9.44 13 305336 639 90322459
Demyelination 12.31 9.44 6 305343 8134 90314964
General symptom 12.26 9.44 19 305330 14649 90308449
Stroke volume increased 12.21 9.44 4 305345 17 90323081
Renal disorder 12.21 9.44 76 305273 37783 90285315
Retrograde amnesia 12.20 9.44 12 305337 542 90322556
Low density lipoprotein increased 12.16 9.44 6 305343 8079 90315019
Stoma site inflammation 12.14 9.44 14 305335 760 90322338
Renal cyst 12.13 9.44 80 305269 12870 90310228
Brain injury 12.13 9.44 55 305294 7683 90315415
Incision site swelling 12.13 9.44 9 305340 275 90322823
Herpes simplex reactivation 12.06 9.44 16 305333 1003 90322095
Serotonin syndrome 12.06 9.44 187 305162 37700 90285398
Post lumbar puncture syndrome 12.05 9.44 15 305334 882 90322216
Sciatica 12.01 9.44 436 304913 100946 90222152
Splenic injury 11.97 9.44 8 305341 206 90322892
End stage renal disease 11.96 9.44 7 305342 8564 90314534
Ear pruritus 11.94 9.44 4 305345 6799 90316299
Sarcoidosis 11.93 9.44 11 305338 10662 90312436
Ileus 11.93 9.44 96 305253 16450 90306648
Delayed recovery from anaesthesia 11.92 9.44 16 305333 1014 90322084
Administration site erythema 11.89 9.44 15 305334 894 90322204
Tooth disorder 11.89 9.44 59 305290 31031 90292067
Multiple drug therapy 11.88 9.44 51 305298 6958 90316140
Regressive behaviour 11.84 9.44 8 305341 210 90322888
Pathological fracture 11.83 9.44 64 305285 9596 90313502
Dyslipidaemia 11.80 9.44 10 305339 10097 90313001
Carcinoid crisis 11.74 9.44 9 305340 289 90322809
Tuberculosis 11.74 9.44 15 305334 12534 90310564
Diabetes mellitus 11.74 9.44 151 305198 64724 90258374
Nephrotic syndrome 11.74 9.44 5 305344 7334 90315764
Gestational diabetes 11.72 9.44 11 305338 10571 90312527
Denture wearer 11.67 9.44 8 305341 215 90322883
Rheumatoid arthritis 11.66 9.44 1394 303955 361220 89961878
Victim of sexual abuse 11.63 9.44 13 305336 682 90322416
Gastrointestinal haemorrhage 11.62 9.44 224 305125 90024 90233074
Cardiac death 11.60 9.44 12 305337 576 90322522
Infection 11.60 9.44 1056 304293 361038 89962060
Implant site infection 11.58 9.44 17 305332 1172 90321926
Depression 11.55 9.44 864 304485 299737 90023361
Proteinuria 11.52 9.44 40 305309 23251 90299847
Skin exfoliation 11.48 9.44 305 305044 67608 90255490
Musculoskeletal stiffness 11.44 9.44 852 304497 295680 90027418
Toe amputation 11.43 9.44 23 305326 2046 90321052
Cytomegalovirus infection reactivation 11.42 9.44 6 305343 7794 90315304
Hypoaesthesia oral 11.40 9.44 22 305327 15578 90307520
Cutaneous vasculitis 11.34 9.44 5 305344 7188 90315910
Pharyngitis 11.33 9.44 37 305312 21910 90301188
Adiposis dolorosa 11.33 9.44 9 305340 305 90322793
Urinary tract obstruction 11.25 9.44 24 305325 2225 90320873
Accidental underdose 11.21 9.44 16 305333 1075 90322023
Metastases to central nervous system 11.17 9.44 99 305250 17443 90305655
Gastroduodenal ulcer 11.14 9.44 10 305339 402 90322696
Head discomfort 11.12 9.44 24 305325 16309 90306789
Opiates positive 11.03 9.44 9 305340 317 90322781
Acute kidney injury 11.02 9.44 1237 304112 319150 90003948
Product preparation error 10.98 9.44 11 305338 10250 90312848
Acne 10.95 9.44 54 305295 28453 90294645
Laryngectomy 10.95 9.44 4 305345 25 90323073
Wrong rate 10.91 9.44 7 305342 168 90322930
Organising pneumonia 10.89 9.44 6 305343 7591 90315507
Atypical femur fracture 10.88 9.44 4 305345 6417 90316681
Intentional overdose 10.87 9.44 237 305112 93597 90229501
Intestinal strangulation 10.83 9.44 6 305343 109 90322989
Tissue infiltration 10.82 9.44 14 305335 856 90322242
Meningitis enterococcal 10.81 9.44 3 305346 6 90323092
Pathogen resistance 10.81 9.44 7 305342 8108 90314990
Cytopenia 10.78 9.44 27 305322 17422 90305676
Exercise tolerance decreased 10.77 9.44 6 305343 7545 90315553
Neurodevelopmental disorder 10.77 9.44 8 305341 245 90322853
Ascites 10.71 9.44 223 305126 47517 90275581
Rash vesicular 10.60 9.44 29 305320 18168 90304930
Injection site cyst 10.54 9.44 6 305343 115 90322983
Sputum discoloured 10.48 9.44 110 305239 20281 90302817
Cerebral infarction 10.44 9.44 50 305299 26546 90296552
Injection site extravasation 10.44 9.44 9 305340 9010 90314088
Rales 10.43 9.44 90 305259 15737 90307361
Erysipelas 10.43 9.44 59 305290 8993 90314105
Deafness neurosensory 10.41 9.44 5 305344 6836 90316262
Heat stroke 10.40 9.44 14 305335 890 90322208
Drug detoxification 10.38 9.44 9 305340 345 90322753
Nephrostomy 10.36 9.44 6 305343 119 90322979
Posterior reversible encephalopathy syndrome 10.33 9.44 118 305231 22221 90300877
Euglycaemic diabetic ketoacidosis 10.28 9.44 4 305345 6197 90316901
Pulmonary embolism 10.23 9.44 539 304810 130281 90192817
Vision blurred 10.21 9.44 288 305061 110005 90213093
Paralysis 10.21 9.44 70 305279 11408 90311690
Enthesopathy 10.15 9.44 10 305339 9394 90313704
Urine output decreased 10.13 9.44 75 305274 12528 90310570
Skin fissures 10.12 9.44 36 305313 20773 90302325
Thyroxine decreased 10.09 9.44 12 305337 673 90322425
Hepatic failure 10.06 9.44 189 305160 39539 90283559
Anaesthetic complication pulmonary 10.05 9.44 5 305344 72 90323026
Learning disability 10.02 9.44 8 305341 273 90322825
Wheelchair user 9.98 9.44 7 305342 7778 90315320
Multiple-drug resistance 9.96 9.44 7 305342 7769 90315329
Deformity 9.95 9.44 16 305333 12154 90310944
Psychotic disorder 9.91 9.44 63 305286 31167 90291931
Metastasis 9.91 9.44 44 305305 6093 90317005
Alkalosis 9.90 9.44 11 305338 573 90322525
Urticaria aquagenic 9.90 9.44 4 305345 34 90323064
Nail bed tenderness 9.87 9.44 9 305340 369 90322729
Blood test abnormal 9.84 9.44 111 305238 20841 90302257
Infusion site haemorrhage 9.82 9.44 3 305346 5408 90317690
Aggression 9.82 9.44 135 305214 26533 90296565
Ventricular septal defect 9.81 9.44 3 305346 5404 90317694
Pustular psoriasis 9.78 9.44 31 305318 18525 90304573
Blood creatine phosphokinase MB increased 9.74 9.44 16 305333 1216 90321882
Intermenstrual bleeding 9.74 9.44 10 305339 9213 90313885
Hypogammaglobulinaemia 9.74 9.44 13 305336 10661 90312437
Pocket erosion 9.72 9.44 3 305346 10 90323088
Gout 9.72 9.44 27 305322 16832 90306266
Neoplasm progression 9.72 9.44 207 305142 44279 90278819
Cardiac disorder 9.70 9.44 134 305215 56738 90266360
Febrile neutropenia 9.64 9.44 638 304711 157711 90165387
Pneumococcal infection 9.62 9.44 16 305333 1229 90321869
Intraocular pressure increased 9.61 9.44 6 305343 7087 90316011
Multiple lentigines syndrome 9.60 9.44 7 305342 208 90322890
Underweight 9.60 9.44 17 305332 1373 90321725
Foetal arrhythmia 9.55 9.44 7 305342 210 90322888
Vitamin B12 decreased 9.53 9.44 3 305346 5307 90317791
Viral upper respiratory tract infection 9.53 9.44 9 305340 8625 90314473
Respiratory rate increased 9.53 9.44 89 305260 15912 90307186
Haemophagocytic lymphohistiocytosis 9.49 9.44 24 305325 15435 90307663
Wound infection staphylococcal 9.48 9.44 26 305323 2827 90320271
Transplant dysfunction 9.46 9.44 3 305346 5279 90317819

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2108.66 10.60 3451 163841 225685 42228358
Drug abuse 1843.22 10.60 2160 165132 102611 42351432
Drug hypersensitivity 1111.33 10.60 1641 165651 97748 42356295
Respiratory depression 843.46 10.60 653 166639 18215 42435828
Overdose 774.23 10.60 1440 165852 103824 42350219
Drug dependence 650.18 10.60 681 166611 28413 42425630
Miosis 571.98 10.60 452 166840 12994 42441049
Substance abuse 464.17 10.60 338 166954 8567 42445476
Poisoning 398.09 10.60 382 166910 14317 42439726
Accidental overdose 330.67 10.60 478 166814 27852 42426191
Somnolence 329.39 10.60 1258 166034 139847 42314196
Death 320.02 10.60 3031 164261 468154 41985889
Respiratory arrest 288.10 10.60 449 166843 27975 42426068
Asphyxia 283.38 10.60 246 167046 8080 42445963
Depressed level of consciousness 280.70 10.60 597 166695 47373 42406670
Sedation 279.55 10.60 460 166832 30015 42424028
Bradypnoea 264.23 10.60 182 167110 4211 42449832
Off label use 261.98 10.60 1457 165835 636878 41817165
Coma 245.25 10.60 605 166687 52949 42401094
Hyperaesthesia 237.98 10.60 193 167099 5759 42448284
Drug withdrawal syndrome 229.03 10.60 348 166944 21201 42432842
Confusional state 197.32 10.60 1228 166064 166369 42287674
Intentional product misuse 174.12 10.60 587 166705 61313 42392730
Unresponsive to stimuli 170.17 10.60 379 166913 31024 42423019
Completed suicide 168.69 10.60 788 166504 95677 42358366
Accidental death 167.44 10.60 120 167172 2963 42451080
Cardio-respiratory arrest 166.65 10.60 558 166734 58078 42395965
Inadequate analgesia 165.79 10.60 121 167171 3076 42450967
Delirium 162.96 10.60 515 166777 52004 42402039
Drug use disorder 161.35 10.60 201 167091 10132 42443911
Pulmonary oedema 154.99 10.60 511 166781 52761 42401282
Drug screen positive 152.72 10.60 128 167164 4003 42450040
Lethargy 150.27 10.60 465 166827 46425 42407618
Constipation 146.34 10.60 1114 166178 161177 42292866
Mental status changes 139.95 10.60 423 166869 41692 42412351
Product dose omission issue 128.85 10.60 257 167035 154108 42299935
Hyperhidrosis 123.64 10.60 690 166602 89822 42364221
Acute chest syndrome 123.07 10.60 67 167225 998 42453045
Withdrawal syndrome 118.29 10.60 210 167082 14565 42439478
Respiratory rate decreased 116.69 10.60 95 167197 2850 42451193
Cardiac arrest 115.61 10.60 780 166512 108540 42345503
Agitation 109.89 10.60 522 166770 63792 42390251
Drug abuser 109.53 10.60 99 167193 3432 42450611
Drug ineffective 107.99 10.60 1784 165508 628413 41825630
Malignant neoplasm progression 106.69 10.60 760 166532 107640 42346403
Myoclonus 102.79 10.60 215 167077 16850 42437193
Apnoea 95.92 10.60 135 167157 7668 42446375
Brain oedema 94.05 10.60 202 167090 16125 42437918
Nausea 93.70 10.60 2125 165167 394674 42059369
Vomiting 91.87 10.60 1622 165670 288101 42165942
COVID-19 83.64 10.60 209 167083 115739 42338304
Substance use disorder 81.89 10.60 103 167189 5242 42448801
Amnestic disorder 80.13 10.60 34 167258 279 42453764
Respiratory acidosis 77.03 10.60 109 167183 6222 42447821
Sedation complication 75.51 10.60 74 167218 2845 42451198
Hypoventilation 74.36 10.60 83 167209 3719 42450324
Sphincter of Oddi dysfunction 72.16 10.60 29 167263 204 42453839
Aggression 71.49 10.60 353 166939 43810 42410233
Pulmonary congestion 70.15 10.60 176 167116 15554 42438489
Cytomegalovirus infection 68.08 10.60 21 167271 32285 42421758
Oxygen saturation decreased 66.80 10.60 459 166833 64228 42389815
Cough 65.83 10.60 419 166873 177684 42276359
Tubulointerstitial nephritis 65.60 10.60 21 167271 31527 42422516
Myelosuppression 65.09 10.60 39 167253 40422 42413621
Drug resistance 64.12 10.60 27 167265 34221 42419822
Myalgia 62.64 10.60 182 167110 95898 42358145
Pneumonia aspiration 61.32 10.60 371 166921 49707 42404336
Condition aggravated 60.19 10.60 694 166598 260060 42193983
Renal impairment 59.37 10.60 227 167065 110001 42344042
Product use in unapproved indication 59.28 10.60 452 166840 184004 42270039
Pain 58.14 10.60 1313 165979 243535 42210508
Hallucination 55.25 10.60 401 166891 57106 42396937
Nightmare 53.33 10.60 217 167075 24795 42429248
Cardiac failure congestive 53.03 10.60 166 167126 85436 42368607
Hospitalisation 52.02 10.60 136 167156 74194 42379849
Poisoning deliberate 51.20 10.60 119 167173 10015 42444028
Sleep disorder due to a general medical condition 50.43 10.60 5 167287 17448 42436595
Respiratory distress 49.42 10.60 307 166985 41513 42412530
Haematochezia 48.94 10.60 97 167195 58339 42395704
Plasma cell myeloma 48.76 10.60 337 166955 47241 42406802
Myocardial infarction 48.25 10.60 287 167005 123722 42330321
Drug diversion 48.13 10.60 36 167256 951 42453092
Loss of personal independence in daily activities 47.76 10.60 76 167216 49740 42404303
Aspiration 47.09 10.60 166 167126 17720 42436323
Delusion of grandeur 46.85 10.60 48 167244 1948 42452095
Treatment failure 46.61 10.60 111 167181 62513 42391530
Exposure via ingestion 46.17 10.60 49 167243 2073 42451970
Rash 45.80 10.60 788 166504 276166 42177877
Sickle cell anaemia with crisis 45.07 10.60 74 167218 4816 42449227
Rhinalgia 44.47 10.60 45 167247 1799 42452244
Brain injury 44.42 10.60 95 167197 7560 42446483
Opiates positive 43.51 10.60 27 167265 520 42453523
Toxic leukoencephalopathy 43.44 10.60 30 167262 697 42453346
Eczema 43.15 10.60 42 167250 34044 42419999
Urinary retention 42.66 10.60 298 166994 41916 42412127
Inspiratory capacity decreased 42.03 10.60 55 167237 2912 42451131
Injection site swelling 41.67 10.60 8 167284 16965 42437078
Accident 41.59 10.60 84 167208 6419 42447624
Accidental poisoning 41.51 10.60 37 167255 1259 42452784
Appendicolith 41.22 10.60 3 167289 13453 42440590
Therapy interrupted 40.92 10.60 18 167274 22232 42431811
No adverse event 40.85 10.60 56 167236 38965 42415078
Hypoxic-ischaemic encephalopathy 40.43 10.60 73 167219 5129 42448914
Syncope 40.30 10.60 227 167065 99179 42354864
Serotonin syndrome 39.99 10.60 204 167088 25641 42428402
PCO2 increased 39.57 10.60 28 167264 677 42453366
Pelvic pain 39.55 10.60 56 167236 3198 42450845
Cerebrovascular accident 39.32 10.60 222 167070 96938 42357105
Bronchiectasis 39.27 10.60 11 167281 18008 42436035
Arthralgia 38.92 10.60 569 166723 204669 42249374
Intestinal obstruction 38.34 10.60 209 167083 26949 42427094
Lymphocyte count abnormal 38.14 10.60 45 167247 2142 42451901
Self-medication 37.93 10.60 55 167237 3211 42450832
Basal cell carcinoma 37.86 10.60 21 167271 22712 42431331
Blood glucose increased 37.62 10.60 155 167137 73544 42380499
Neoplasm progression 37.52 10.60 218 167074 28782 42425261
Drug-induced liver injury 37.05 10.60 58 167234 38215 42415828
Hypoxia 37.01 10.60 428 166864 69358 42384685
Atrial fibrillation 36.81 10.60 360 166932 139233 42314810
Allodynia 36.57 10.60 32 167260 1062 42452981
Spinal cord compression 36.36 10.60 62 167230 4162 42449881
Breakthrough pain 36.34 10.60 25 167267 577 42453466
Dyspnoea 36.32 10.60 1396 165896 441225 42012818
Hypogonadism male 36.14 10.60 21 167271 357 42453686
Dizziness 35.96 10.60 726 166566 248528 42205515
Bradykinesia 35.70 10.60 71 167221 5365 42448678
Cancer pain 35.64 10.60 56 167236 3511 42450532
Melaena 35.38 10.60 61 167231 38685 42415358
Terminal insomnia 35.06 10.60 29 167263 890 42453153
Cardiac failure 34.69 10.60 261 167031 106595 42347448
Therapeutic product effect incomplete 34.48 10.60 152 167140 70787 42383256
Injection site pain 34.45 10.60 114 167178 57684 42396359
Sinusitis 34.26 10.60 85 167207 47207 42406836
Product used for unknown indication 34.00 10.60 32 167260 1169 42452874
Nephrolithiasis 33.76 10.60 254 167038 36576 42417467
Inappropriate schedule of product administration 33.18 10.60 230 167062 95672 42358371
Back pain 32.86 10.60 758 166534 141018 42313025
Mechanical ventilation complication 32.83 10.60 25 167267 679 42453364
Disease recurrence 32.69 10.60 41 167251 29637 42424406
Weight increased 32.61 10.60 269 167023 107714 42346329
Exposure to toxic agent 32.44 10.60 65 167227 4939 42449104
Stupor 32.19 10.60 50 167242 3103 42450940
Neuroblastoma recurrent 31.92 10.60 20 167272 392 42453651
Blood pH decreased 31.63 10.60 42 167250 2256 42451787
Clumsiness 31.34 10.60 38 167254 1862 42452181
Pathogen resistance 31.27 10.60 4 167288 11446 42442597
Foetal exposure during pregnancy 31.27 10.60 89 167203 47222 42406821
Diaphragmatic spasm 31.03 10.60 13 167279 103 42453940
Diabetes mellitus inadequate control 30.68 10.60 11 167281 15379 42438664
Dyspnoea exertional 30.52 10.60 98 167194 50050 42403993
Blood cholesterol increased 30.45 10.60 36 167256 26705 42427338
Transplant rejection 30.16 10.60 8 167284 13580 42440463
Interstitial lung disease 29.76 10.60 183 167109 78279 42375764
Visual acuity reduced 29.54 10.60 16 167276 17534 42436509
Hepatic function abnormal 29.18 10.60 104 167188 51463 42402580
Sinus tachycardia 28.52 10.60 158 167134 20495 42433548
Impaired quality of life 28.49 10.60 10 167282 14167 42439876
Toxicologic test abnormal 28.39 10.60 20 167272 480 42453563
Metastases to bone 28.09 10.60 124 167168 14685 42439358
Affective disorder 27.96 10.60 68 167224 5892 42448151
Glycosylated haemoglobin increased 27.96 10.60 8 167284 12916 42441127
Body temperature increased 27.62 10.60 155 167137 20203 42433840
Drug eruption 27.43 10.60 30 167262 23045 42430998
Postoperative ileus 27.42 10.60 23 167269 720 42453323
Glomerular filtration rate decreased 27.38 10.60 15 167277 16336 42437707
Diarrhoea 27.37 10.60 1505 165787 459344 41994699
Encephalopathy 27.30 10.60 265 167027 41068 42412975
Progressive multifocal leukoencephalopathy 27.16 10.60 6 167286 11530 42442513
Device programming error 26.95 10.60 12 167280 112 42453931
Dependence 26.72 10.60 31 167261 1449 42452594
Anal inflammation 26.56 10.60 38 167254 2191 42451852
Vasculitis 26.53 10.60 20 167272 18374 42435669
Systemic lupus erythematosus 26.10 10.60 3 167289 9321 42444722
Disorientation 25.88 10.60 237 167055 36152 42417891
Restlessness 25.84 10.60 200 167092 29049 42424994
Haematuria 25.64 10.60 128 167164 57671 42396372
Hypertension 25.30 10.60 483 166809 166721 42287322
SARS-CoV-2 test negative 25.30 10.60 33 167259 1742 42452301
Dry skin 25.08 10.60 101 167191 48237 42405806
Pupillary reflex impaired 25.01 10.60 32 167260 1657 42452386
Failure to suspend medication 24.99 10.60 17 167275 385 42453658
Adulterated product 24.79 10.60 22 167270 744 42453299
Headache 24.71 10.60 733 166559 238636 42215407
White blood cell count decreased 24.56 10.60 296 166996 110100 42343943
Orthostatic hypotension 24.52 10.60 52 167240 30518 42423525
Pulmonary fibrosis 24.36 10.60 42 167250 26639 42427404
Hypotension 24.28 10.60 1240 166052 256391 42197652
Thrombotic microangiopathy 24.12 10.60 14 167278 14768 42439275
Peripheral swelling 24.12 10.60 232 167060 90038 42364005
Cardiac murmur 24.03 10.60 10 167282 12765 42441278
Respiratory failure 23.77 10.60 665 166627 127467 42326576
Polyneuropathy in malignant disease 23.61 10.60 16 167276 360 42453683
Hallucination, visual 23.40 10.60 152 167140 20868 42433175
Neuroblastoma 23.33 10.60 15 167277 308 42453735
Chronic kidney disease 23.09 10.60 101 167191 47140 42406903
Faecal volume decreased 23.01 10.60 13 167279 209 42453834
Nerve injury 22.89 10.60 49 167243 3901 42450142
Diabetes mellitus 22.86 10.60 140 167152 59947 42394096
Drug tolerance 22.86 10.60 44 167248 3246 42450797
Pulmonary haemorrhage 22.82 10.60 97 167195 11300 42442743
Substance use 22.57 10.60 31 167261 1720 42452323
Psoriasis 22.51 10.60 106 167186 48498 42405545
Drug reaction with eosinophilia and systemic symptoms 22.41 10.60 87 167205 41988 42412055
Impaired driving ability 22.37 10.60 41 167251 2914 42451129
Hepatic cytolysis 22.32 10.60 181 167111 26663 42427380
Colitis ulcerative 22.30 10.60 43 167249 26132 42427911
Wheezing 22.24 10.60 125 167167 54656 42399387
Full blood count abnormal 22.19 10.60 53 167239 29823 42424220
Coronary artery disease 22.13 10.60 122 167170 53598 42400445
Chemical poisoning 22.03 10.60 10 167282 98 42453945
Bladder dilatation 21.91 10.60 30 167262 1660 42452383
Therapeutic response shortened 21.89 10.60 13 167279 13541 42440502
Hypercapnia 21.85 10.60 58 167234 5303 42448740
Proctalgia 21.47 10.60 69 167223 7024 42447019
Anaemia 21.40 10.60 891 166401 279387 42174656
Fatigue 21.38 10.60 1448 165844 434193 42019850
Neuroleptic malignant syndrome 21.30 10.60 32 167260 21440 42432603
Asthma 21.27 10.60 150 167142 62164 42391879
Intentional product use issue 21.20 10.60 180 167112 71653 42382390
Visual impairment 21.17 10.60 92 167200 43021 42411022
Appendicitis 21.15 10.60 30 167262 20583 42433460
Syringe issue 21.08 10.60 4 167288 8552 42445491
Eye irritation 21.06 10.60 9 167283 11309 42442734
Angiopathy 20.74 10.60 57 167235 5320 42448723
Nasopharyngitis 20.73 10.60 220 167072 83776 42370267
Psychotic behaviour 20.70 10.60 22 167270 932 42453111
Post procedural complication 20.62 10.60 101 167191 12489 42441554
Diabetic ketoacidosis 20.61 10.60 35 167257 22332 42431711
Cholestasis 20.35 10.60 208 167084 32671 42421372
Iron deficiency 20.26 10.60 9 167283 11052 42442991
Neutropenia 20.24 10.60 612 166680 198819 42255224
Bronchopulmonary aspergillosis 20.21 10.60 28 167264 19401 42434642
Skin exfoliation 20.21 10.60 89 167203 41464 42412579
Lactic acidosis 20.21 10.60 100 167192 45161 42408882
Vestibular disorder 20.17 10.60 24 167268 1153 42452890
Gas poisoning 20.12 10.60 9 167283 85 42453958
Palpitations 20.04 10.60 117 167175 50680 42403363
Hypogonadism 20 10.60 35 167257 2399 42451644
Tachycardia 19.98 10.60 529 166763 100558 42353485
Nephropathy toxic 19.90 10.60 22 167270 16816 42437227
Abdominal compartment syndrome 19.71 10.60 23 167269 1082 42452961
Lung cancer metastatic 19.61 10.60 39 167253 2947 42451096
Cyanosis 19.44 10.60 113 167179 14918 42439125
Mydriasis 19.42 10.60 77 167215 8693 42445350
Epstein-Barr virus infection 19.28 10.60 7 167285 9711 42444332
Accidental underdose 19.23 10.60 18 167274 653 42453390
Patient uncooperative 19.23 10.60 18 167274 653 42453390
Anorgasmia 19.18 10.60 23 167269 1114 42452929
Rebound effect 19.16 10.60 3 167289 7376 42446667
Product storage error 18.98 10.60 10 167282 11130 42442913
Logorrhoea 18.84 10.60 37 167255 2770 42451273
Drug level 18.80 10.60 5 167287 6 42454037
Weaning failure 18.72 10.60 12 167280 245 42453798
Myopathy 18.55 10.60 16 167276 13745 42440298
Muscle swelling 18.45 10.60 15 167277 449 42453594
Product dose omission in error 18.39 10.60 5 167287 8349 42445694
Salivary hypersecretion 18.38 10.60 10 167282 10933 42443110
Frequent bowel movements 18.38 10.60 35 167257 21372 42432671
Pathological fracture 18.36 10.60 54 167238 5239 42448804
Injection site pruritus 18.28 10.60 7 167285 9398 42444645
Cerebral infarction 18.21 10.60 62 167230 31107 42422936
Squamous cell carcinoma of skin 18.15 10.60 14 167278 12712 42441331
Treatment noncompliance 18.13 10.60 81 167211 37591 42416452
Brain hypoxia 18.09 10.60 17 167275 620 42453423
Cluster headache 17.91 10.60 16 167276 546 42453497
Intestinal intraepithelial lymphocytes increased 17.90 10.60 11 167281 208 42453835
Cutaneous T-cell lymphoma stage I 17.81 10.60 9 167283 114 42453929
Accidental exposure to product by child 17.63 10.60 26 167266 1541 42452502
Acute pulmonary oedema 17.61 10.60 74 167218 8577 42445466
Bradyphrenia 17.60 10.60 53 167239 5209 42448834
Suspected suicide 17.60 10.60 59 167233 6140 42447903
Substance dependence 17.53 10.60 17 167275 645 42453398
Reaction to excipient 17.53 10.60 17 167275 645 42453398
Erythema 17.46 10.60 311 166981 108482 42345561
Tooth injury 17.43 10.60 23 167269 1228 42452815
Herpes simplex viraemia 17.41 10.60 9 167283 120 42453923
Emphysema 17.33 10.60 92 167200 11743 42442300
Cardiac failure chronic 17.29 10.60 8 167284 9593 42444450
Procedural vomiting 17.23 10.60 11 167281 223 42453820
Acute graft versus host disease in skin 17.20 10.60 4 167288 7420 42446623
Angina unstable 17.09 10.60 12 167280 11436 42442607
Apnoeic attack 17.04 10.60 15 167277 502 42453541
Subarachnoid haemorrhage 17 10.60 19 167273 14453 42439590
Eye pruritus 16.99 10.60 12 167280 11400 42442643
Oesophagitis chemical 16.98 10.60 7 167285 53 42453990
Gout 16.95 10.60 55 167237 28000 42426043
Hepatitis B 16.83 10.60 3 167289 6708 42447335
Chest discomfort 16.78 10.60 164 167128 63452 42390591
Urine alcohol test positive 16.76 10.60 7 167285 55 42453988
Productive cough 16.70 10.60 126 167166 51441 42402602
Blindness 16.69 10.60 28 167264 17950 42436093
Disease prodromal stage 16.63 10.60 6 167286 30 42454013
Blood uric acid increased 16.58 10.60 22 167270 15525 42438518
Non-small cell lung cancer 16.55 10.60 50 167242 4924 42449119
Head injury 16.52 10.60 35 167257 20547 42433496
Multiple sclerosis relapse 16.46 10.60 19 167273 14245 42439798
Incoherent 16.45 10.60 48 167244 4637 42449406
Biliary obstruction 16.40 10.60 38 167254 3191 42450852
Wrong technique in product usage process 16.39 10.60 99 167193 42536 42411507
Injection site warmth 16.38 10.60 34 167258 2649 42451394
Impaired work ability 16.37 10.60 14 167278 12077 42441966
Blood phosphorus increased 16.36 10.60 15 167277 12510 42441533
C-reactive protein abnormal 16.24 10.60 8 167284 9253 42444790
Fungating wound 16.23 10.60 7 167285 60 42453983
Urinary tract infection 16.19 10.60 283 167009 99001 42355042
Growth hormone-producing pituitary tumour 16.19 10.60 9 167283 140 42453903
Nephrotic syndrome 16.11 10.60 7 167285 8711 42445332
Neuropathy peripheral 16.08 10.60 292 167000 101561 42352482
Arthritis 16.00 10.60 98 167194 41967 42412076
Loss of consciousness 15.93 10.60 475 166817 91879 42362164
Decerebration 15.85 10.60 5 167287 15 42454028
Carcinoid tumour 15.84 10.60 11 167281 258 42453785
Haematotoxicity 15.77 10.60 12 167280 10973 42443070
Leukoencephalopathy 15.74 10.60 49 167243 4905 42449138
Vision blurred 15.65 10.60 135 167157 53564 42400479
Post laminectomy syndrome 15.57 10.60 10 167282 205 42453838
Neurological examination abnormal 15.57 10.60 12 167280 332 42453711
Gastrointestinal motility disorder 15.53 10.60 35 167257 2886 42451157
Therapy cessation 15.41 10.60 36 167256 20414 42433629
Therapy partial responder 15.28 10.60 35 167257 19986 42434057
Ileus paralytic 15.27 10.60 65 167227 7576 42446467
Parathyroid hormone-related protein abnormal 15.16 10.60 5 167287 18 42454025
Tumour pain 15.16 10.60 22 167270 1285 42452758
Herpes zoster 15.09 10.60 90 167202 38787 42415256
Angina pectoris 15.08 10.60 72 167220 32824 42421219
Cryptitis 15.06 10.60 11 167281 280 42453763
Pupil fixed 15.02 10.60 27 167265 1890 42452153
Infusion site granuloma 14.95 10.60 4 167288 5 42454038
Abnormal behaviour 14.81 10.60 164 167128 26287 42427756
Poor venous access 14.77 10.60 5 167287 7247 42446796
Medical device site infection 14.76 10.60 11 167281 289 42453754
Device failure 14.73 10.60 33 167259 2710 42451333
Hypogammaglobulinaemia 14.65 10.60 15 167277 11876 42442167
Acute respiratory failure 14.63 10.60 224 167068 38634 42415409
Proteinuria 14.63 10.60 44 167248 22939 42431104
Cerebrospinal fluid leakage 14.60 10.60 16 167276 702 42453341
Intentional misuse of drug delivery system 14.56 10.60 5 167287 21 42454022
Acute graft versus host disease 14.55 10.60 7 167285 8208 42445835
Tuberculosis 14.54 10.60 11 167281 10088 42443955
Bladder cancer 14.52 10.60 28 167264 17019 42437024
Parosmia 14.50 10.60 6 167286 7685 42446358
Microvillous inclusion disease 14.45 10.60 10 167282 233 42453810
Postmortem blood drug level abnormal 14.40 10.60 12 167280 372 42453671
Drug interaction 14.27 10.60 1225 166067 265774 42188269
Electrocardiogram low voltage 14.20 10.60 5 167287 23 42454020
Device toxicity 14.20 10.60 5 167287 23 42454020
Scan gallium abnormal 14.03 10.60 5 167287 24 42454019
Rash pruritic 14.01 10.60 76 167216 33527 42420516
Eosinophil count increased 13.93 10.60 13 167279 10750 42443293
Medical device site haemorrhage 13.92 10.60 8 167284 133 42453910
Cytopenia 13.84 10.60 30 167262 17467 42436576
Monocytopenia 13.83 10.60 7 167285 89 42453954
Respiration abnormal 13.79 10.60 41 167251 4001 42450042
Respiratory tract infection 13.65 10.60 55 167237 26267 42427776
Arrhythmia neonatal 13.63 10.60 3 167289 0 42454043
Diplopia 13.58 10.60 38 167254 20278 42433765
Skin haemorrhage 13.55 10.60 7 167285 7878 42446165
Pemphigoid 13.53 10.60 15 167277 11452 42442591
Screaming 13.48 10.60 26 167266 1921 42452122
Large intestine polyp 13.46 10.60 10 167282 9255 42444788
Coma scale abnormal 13.45 10.60 44 167248 4521 42449522
Oesophageal carcinoma 13.41 10.60 11 167281 9685 42444358
Pruritus 13.37 10.60 605 166687 188166 42265877
Carcinoid crisis 13.31 10.60 10 167282 266 42453777
Fall 13.28 10.60 769 166523 233751 42220292
Ileus 13.27 10.60 124 167168 19015 42435028
Metastases to spine 13.27 10.60 34 167258 3043 42451000
Cachexia 13.26 10.60 65 167227 8039 42446004
Atrioventricular block complete 13.26 10.60 15 167277 11349 42442694
General physical health deterioration 13.22 10.60 723 166569 150523 42303520
Acidosis 13.18 10.60 88 167204 12191 42441852
Transient ischaemic attack 13.15 10.60 78 167214 33661 42420382
Gastric hypomotility 13.11 10.60 9 167283 207 42453836
Fungal infection 13.10 10.60 37 167255 19685 42434358
Kidney transplant rejection 13.10 10.60 9 167283 8674 42445369
Small intestinal obstruction 13.09 10.60 113 167179 16948 42437095
Postmortem blood drug level increased 13.09 10.60 13 167279 508 42453535
Tachyphylaxis 13.03 10.60 8 167284 151 42453892
Haemophagocytic lymphohistiocytosis 13.00 10.60 33 167259 18189 42435854
Medical device site bruise 12.93 10.60 4 167288 11 42454032
Visceral oedema 12.86 10.60 6 167286 63 42453980
Eosinophilia 12.85 10.60 76 167216 32823 42421220
Probiotic therapy 12.85 10.60 8 167284 155 42453888
Red blood cell sedimentation rate increased 12.83 10.60 12 167280 9912 42444131
Eye pain 12.81 10.60 30 167262 17000 42437043
Central pain syndrome 12.80 10.60 8 167284 156 42453887
Drug effective for unapproved indication 12.79 10.60 5 167287 6628 42447415
Intentional dose omission 12.67 10.60 10 167282 8976 42445067
Visceral congestion 12.65 10.60 17 167275 924 42453119
Bone marrow failure 12.64 10.60 77 167215 33016 42421027
Metastatic renal cell carcinoma 12.64 10.60 27 167265 2147 42451896
Injection site bruising 12.61 10.60 16 167276 11509 42442534
Dyschezia 12.57 10.60 24 167268 1760 42452283
Ischaemic stroke 12.47 10.60 45 167247 22188 42431855
Dependence on oxygen therapy 12.46 10.60 9 167283 225 42453818
Retinal detachment 12.44 10.60 5 167287 6520 42447523
Renal disorder 12.38 10.60 65 167227 28915 42425128
Paraparesis 12.36 10.60 26 167266 2045 42451998
Medical device site erythema 12.34 10.60 5 167287 36 42454007
Post stroke epilepsy 12.34 10.60 5 167287 36 42454007
Infusion site pain 12.31 10.60 3 167289 5392 42448651
Necrotising colitis 12.30 10.60 20 167272 1291 42452752
Immune reconstitution inflammatory syndrome 12.26 10.60 13 167279 10130 42443913
Atrial septal defect 12.23 10.60 8 167284 7911 42446132
Cheyne-Stokes respiration 12.17 10.60 10 167282 304 42453739
Acute myocardial infarction 12.16 10.60 158 167134 58007 42396036
Drug detoxification 12.15 10.60 11 167281 382 42453661
Arachnoiditis 12.13 10.60 11 167281 383 42453660
Myelodysplastic syndrome 12.13 10.60 47 167245 22698 42431345
Nodule 12.12 10.60 19 167273 12515 42441528
Haemorrhagic stroke 12.09 10.60 7 167285 7395 42446648
Nephropathy 12.08 10.60 6 167286 6905 42447138
Product prescribing error 12.05 10.60 57 167235 26055 42427988
Hypoglycaemia 12 10.60 164 167128 59690 42394353
Antasthmatic drug level 11.89 10.60 5 167287 40 42454003
Dysarthria 11.89 10.60 221 167071 39586 42414457
Product residue present 11.85 10.60 31 167261 2810 42451233
Viral diarrhoea 11.84 10.60 10 167282 316 42453727
Oral mucosal eruption 11.82 10.60 11 167281 396 42453647
Electroencephalogram abnormal 11.82 10.60 32 167260 2960 42451083
Cataract 11.80 10.60 71 167221 30533 42423510
Abdominal discomfort 11.80 10.60 216 167076 75039 42379004
Blood chromogranin A increased 11.79 10.60 10 167282 318 42453725
Cytomegalovirus viraemia 11.78 10.60 14 167278 10363 42443680
C-reactive protein increased 11.74 10.60 177 167115 63383 42390660
Pulmonary toxicity 11.74 10.60 10 167282 8645 42445398
Metastases to lung 11.74 10.60 81 167211 11343 42442700
Osteopenia 11.67 10.60 5 167287 6273 42447770
Hyponatraemia 11.65 10.60 306 166986 101156 42352887
Haemothorax 11.62 10.60 46 167246 5190 42448853
Obesity 11.60 10.60 30 167262 16429 42437614
Photosensitivity reaction 11.59 10.60 20 167272 12682 42441361
Kidney infection 11.59 10.60 55 167237 6715 42447328
Analgesic drug level 11.58 10.60 5 167287 43 42454000
Anosmia 11.58 10.60 3 167289 5173 42448870
Histamine intolerance 11.57 10.60 3 167289 3 42454040
Alpha 1 globulin increased 11.57 10.60 3 167289 3 42454040
Infantile fibromatosis 11.57 10.60 3 167289 3 42454040
Foetal exposure during delivery 11.55 10.60 7 167285 129 42453914
Iron deficiency anaemia 11.48 10.60 21 167271 13018 42441025
Dyslipidaemia 11.47 10.60 12 167280 9406 42444637
Blood pH increased 11.37 10.60 14 167278 697 42453346
Parkinsonism 11.36 10.60 15 167277 10608 42443435
Gallbladder injury 11.36 10.60 8 167284 192 42453851
Squamous cell carcinoma 11.34 10.60 21 167271 12961 42441082
Medication error 11.31 10.60 188 167104 32966 42421077
Hypothermia 11.29 10.60 86 167206 12429 42441614
Liver function test 11.29 10.60 6 167286 85 42453958
Balance disorder 11.27 10.60 126 167166 47519 42406524
Conjunctivitis 11.24 10.60 21 167271 12918 42441125
Increased appetite 11.24 10.60 11 167281 8895 42445148
Contraindicated product administered 11.18 10.60 56 167236 25216 42428827
Blood triglycerides increased 11.18 10.60 29 167263 15867 42438176
Narcotic bowel syndrome 11.14 10.60 7 167285 138 42453905
Exposure via skin contact 11.12 10.60 3 167289 5035 42449008
Hyperthyroidism 11.00 10.60 25 167267 14316 42439727
Shunt malfunction 11.00 10.60 9 167283 272 42453771
Victim of homicide 10.94 10.60 8 167284 204 42453839
Akathisia 10.93 10.60 15 167277 10436 42443607
Conjunctival discolouration 10.93 10.60 4 167288 21 42454022
Pulmonary tuberculosis 10.85 10.60 4 167288 5497 42448546
Cardiomegaly 10.83 10.60 107 167185 16659 42437384
Subdural effusion 10.81 10.60 6 167286 93 42453950
Alanine aminotransferase abnormal 10.81 10.60 3 167289 4941 42449102
Dehiscence 10.79 10.60 13 167279 633 42453410
Device computer issue 10.78 10.60 4 167288 22 42454021
Intervertebral disc injury 10.78 10.60 4 167288 22 42454021
COVID-19 pneumonia 10.68 10.60 46 167246 21567 42432476
Infective pulmonary exacerbation of cystic fibrosis 10.65 10.60 9 167283 7809 42446234

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 4785.73 9.75 6996 395613 447094 109739596
Drug abuse 2959.34 9.75 3434 399175 173977 110012713
Toxicity to various agents 2869.69 9.75 5757 396852 474798 109711892
Respiratory depression 1321.43 9.75 1025 401584 30976 110155714
Overdose 1132.65 9.75 2577 400032 231217 109955473
Miosis 883.42 9.75 693 401916 21290 110165400
Depressed level of consciousness 794.83 9.75 1449 401160 110829 110075861
Sedation 780.02 9.75 1108 401501 68575 110118115
Death 767.67 9.75 4753 397856 694116 109492574
Respiratory arrest 671.76 9.75 940 401669 57359 110129331
Constipation 628.30 9.75 2774 399835 355012 109831678
Accidental overdose 623.07 9.75 853 401756 50981 110135709
Substance abuse 605.19 9.75 440 402169 12023 110174667
Drug dependence 601.02 9.75 823 401786 49197 110137493
Somnolence 587.09 9.75 2390 400219 295059 109891631
Bradypnoea 510.13 9.75 344 402265 8305 110178385
Poisoning 478.55 9.75 560 402049 28545 110158145
Coma 477.35 9.75 1213 401396 116656 110070034
Sedation complication 467.47 9.75 462 402147 19393 110167297
Completed suicide 465.81 9.75 1932 400677 240449 109946241
Hyperaesthesia 425.78 9.75 384 402225 14343 110172347
Cardio-respiratory arrest 390.44 9.75 1114 401495 114722 110071968
Drug withdrawal syndrome 360.96 9.75 560 402049 37494 110149196
Asphyxia 351.91 9.75 340 402269 13875 110172815
Intentional product misuse 345.76 9.75 1168 401441 131736 110054954
Creatinine renal clearance decreased 340.90 9.75 409 402200 21406 110165284
Cardiac arrest 327.98 9.75 1503 401106 195250 109991440
Off label use 276.83 9.75 3827 398782 1496358 108690332
Blood calcium decreased 273.22 9.75 478 402131 35367 110151323
Unresponsive to stimuli 271.30 9.75 669 401940 63121 110123569
Respiratory rate decreased 263.83 9.75 203 402406 6055 110180635
Drug use disorder 236.36 9.75 310 402299 17764 110168926
Delirium 217.94 9.75 1022 401587 134003 110052687
Drug screen positive 211.10 9.75 180 402429 6230 110180460
Accidental death 201.42 9.75 158 402451 4851 110181839
COVID-19 200.39 9.75 366 402243 244694 109941996
Myoclonus 200.18 9.75 399 402210 32599 110154091
Product dose omission issue 194.21 9.75 566 402043 321216 109865474
Acute chest syndrome 193.49 9.75 111 402498 1992 110184698
Mental status changes 190.90 9.75 661 401948 75461 110111229
Vomiting 188.23 9.75 4488 398121 906187 109280503
Lethargy 186.71 9.75 755 401854 92821 110093869
Inadequate analgesia 184.67 9.75 151 402458 4926 110181764
Drug abuser 184.51 9.75 155 402454 5254 110181436
Systemic lupus erythematosus 179.83 9.75 413 402196 253925 109932765
Maternal exposure during delivery 173.39 9.75 126 402483 3439 110183251
Folliculitis 161.00 9.75 225 402384 167428 110019262
Abdominal discomfort 158.92 9.75 815 401794 393043 109793647
Hyperhidrosis 157.67 9.75 1195 401414 186103 110000587
Pulmonary oedema 152.35 9.75 748 401861 99911 110086779
Apnoea 151.25 9.75 216 402393 13423 110173267
Malignant neoplasm progression 149.31 9.75 1118 401491 173449 110013241
Condition aggravated 148.95 9.75 1836 400773 733000 109453690
Confusional state 148.45 9.75 2464 400145 466216 109720474
Arthralgia 148.39 9.75 1974 400635 777658 109409032
Exposure via ingestion 148.05 9.75 131 402478 4769 110181921
Weight increased 145.19 9.75 913 401696 418731 109767959
Nausea 141.08 9.75 5664 396945 1230026 108956664
Drug ineffective 140.64 9.75 4343 398266 1516197 108670493
Withdrawal syndrome 139.70 9.75 335 402274 31045 110155645
Alopecia 138.13 9.75 771 401838 363982 109822708
Irritable bowel syndrome 138.04 9.75 241 402368 163974 110022716
Hypotension 133.57 9.75 2662 399947 521187 109665503
Myelosuppression 129.03 9.75 93 402516 94247 110092443
Sphincter of Oddi dysfunction 128.94 9.75 56 402553 532 110186158
Agitation 127.22 9.75 775 401834 112276 110074414
Brain oedema 126.80 9.75 321 402288 30777 110155913
Pemphigus 125.38 9.75 383 402226 214187 109972503
Glossodynia 124.98 9.75 403 402206 221601 109965089
Respiratory acidosis 124.91 9.75 199 402410 13627 110173063
Poisoning deliberate 123.63 9.75 287 402322 26044 110160646
Personality disorder 121.84 9.75 189 402420 12648 110174042
Anterior spinal artery syndrome 120.80 9.75 41 402568 181 110186509
Hypoxia 117.33 9.75 841 401768 128674 110058016
Arthropathy 117.03 9.75 593 402016 286929 109899761
Hallucination 116.45 9.75 699 401910 100733 110085957
Pericarditis 115.00 9.75 410 402199 218704 109967986
Contrast media allergy 114.52 9.75 97 402512 3326 110183364
Hand deformity 112.60 9.75 412 402197 218094 109968596
Orthostatic hypotension 111.69 9.75 508 402101 65741 110120949
Duodenal ulcer perforation 111.24 9.75 307 402302 177393 110009297
Swelling 109.74 9.75 787 401822 350254 109836436
Drug diversion 109.01 9.75 66 402543 1314 110185376
Helicobacter infection 108.87 9.75 321 402288 181556 110005134
Gangrene 108.14 9.75 205 402404 16136 110170554
Intentional product use issue 107.43 9.75 500 402109 247406 109939284
Aggression 106.60 9.75 463 402146 58747 110127943
Cognitive disorder 106.23 9.75 612 401997 86899 110099791
Muscle injury 105.78 9.75 221 402388 140586 110046104
Peripheral swelling 104.62 9.75 953 401656 403081 109783609
Aspiration 103.15 9.75 294 402315 30239 110156451
Temperature regulation disorder 102.92 9.75 175 402434 12651 110174039
Carotid artery thrombosis 101.57 9.75 149 402460 9489 110177201
Substance use disorder 101.52 9.75 129 402480 7161 110179529
Neurologic neglect syndrome 101.27 9.75 146 402463 9152 110177538
Sensory loss 100.87 9.75 234 402375 21223 110165467
Impaired healing 100.65 9.75 372 402237 196345 109990345
Blepharospasm 100.35 9.75 37 402572 54814 110131876
Urinary retention 97.13 9.75 506 402103 69177 110117513
Cardiac failure congestive 96.67 9.75 258 402351 150742 110035948
Nail disorder 94.90 9.75 46 402563 57889 110128801
Retinitis 94.73 9.75 296 402313 32031 110154659
Onychomycosis 94.03 9.75 14 402595 38517 110148173
Balance disorder 93.77 9.75 736 401873 115824 110070866
Injection site reaction 93.26 9.75 112 402497 88958 110097732
Injection site swelling 92.52 9.75 55 402554 61735 110124955
Product quality issue 91.16 9.75 88 402521 77211 110109479
Device expulsion 88.89 9.75 6 402603 30885 110155805
Injection site pain 88.71 9.75 340 402269 177582 110009108
Foetal death 87.86 9.75 186 402423 15859 110170831
Gastrooesophageal reflux disease 87.77 9.75 347 402262 179629 110007061
Onychomadesis 86.63 9.75 29 402580 45634 110141056
Taste disorder 86.14 9.75 67 402542 65320 110121370
Arterial occlusive disease 85.62 9.75 179 402430 15129 110171561
Adjustment disorder 82.31 9.75 144 402465 10651 110176039
Oxygen saturation decreased 82.18 9.75 904 401705 156078 110030612
Psoriatic arthropathy 81.07 9.75 404 402205 196357 109990333
Anti-cyclic citrullinated peptide antibody positive 80.64 9.75 364 402245 181620 110005070
Hypoventilation 79.54 9.75 121 402488 7960 110178730
Cytomegalovirus infection 79.37 9.75 50 402559 54394 110132296
Rash 78.66 9.75 2332 400277 818632 109368058
Injection site pruritus 77.63 9.75 45 402564 51213 110135477
Hypercapnia 77.60 9.75 143 402466 11016 110175674
Joint dislocation 76.43 9.75 286 402323 33904 110152786
Wound 75.96 9.75 520 402089 233917 109952773
Injection site erythema 74.86 9.75 143 402466 94033 110092657
Ill-defined disorder 74.85 9.75 305 402304 156548 110030142
Toxicologic test abnormal 74.73 9.75 51 402558 1256 110185434
Synovitis 73.76 9.75 640 401969 273452 109913238
Therapy interrupted 73.68 9.75 45 402564 49777 110136913
Respiratory failure 70.98 9.75 1140 401469 214192 109972498
Epilepsy 70.55 9.75 163 402446 100046 110086644
Finger deformity 70.20 9.75 17 402592 33075 110153615
Hospitalisation 69.94 9.75 274 402335 142219 110044471
Pulmonary congestion 69.20 9.75 259 402350 30707 110155983
Drug resistance 69.04 9.75 62 402547 56312 110130378
Stomatitis 68.79 9.75 640 401969 269602 109917088
Dyspnoea 68.53 9.75 3313 399296 1103559 109083131
Cholestasis 68.01 9.75 435 402174 64083 110122607
Blister 67.55 9.75 517 402092 226859 109959831
Nasopharyngitis 66.89 9.75 1021 401588 393340 109793350
Opiates positive 66.78 9.75 42 402567 897 110185793
Coordination abnormal 65.80 9.75 222 402387 25006 110161684
Dermatitis atopic 65.37 9.75 8 402601 25533 110161157
Tubulointerstitial nephritis 64.94 9.75 61 402548 54223 110132467
Wheezing 64.72 9.75 605 402004 254625 109932065
Diarrhoea 64.33 9.75 3443 399166 1136062 109050628
Muscle spasticity 64.00 9.75 280 402329 35635 110151055
Device programming error 63.76 9.75 30 402579 349 110186341
Product use in unapproved indication 63.61 9.75 1196 401413 446181 109740509
Back injury 63.16 9.75 48 402561 47351 110139339
Exostosis 62.86 9.75 332 402277 45624 110141066
Myalgia 62.19 9.75 514 402095 221867 109964823
Type 2 diabetes mellitus 62.03 9.75 384 402225 176848 110009842
Red blood cell sedimentation rate abnormal 61.94 9.75 8 402601 24501 110162189
Nightmare 61.81 9.75 293 402316 38570 110148120
Respiratory distress 61.64 9.75 446 402163 68428 110118262
Gait inability 61.48 9.75 271 402338 136105 110050585
Encephalopathy 61.47 9.75 505 402104 80550 110106140
Nasal congestion 61.34 9.75 170 402439 98112 110088578
Dyspnoea exertional 61.29 9.75 185 402424 103875 110082815
Dizziness 60.57 9.75 2009 400600 696184 109490506
Plasma cell myeloma 59.50 9.75 413 402196 62523 110124167
Therapeutic product effect decreased 59.46 9.75 585 402024 243731 109942959
Foot deformity 59.45 9.75 340 402269 48140 110138550
Acidosis 59.41 9.75 199 402410 22332 110164358
Bone erosion 59.37 9.75 329 402280 46042 110140648
Neutropenic sepsis 58.88 9.75 245 402364 30501 110156189
Accidental exposure to product by child 58.43 9.75 65 402544 3133 110183557
No adverse event 57.92 9.75 113 402496 73726 110112964
Motor dysfunction 57.79 9.75 208 402401 24198 110162492
Impaired quality of life 57.05 9.75 19 402590 29998 110156692
Fatigue 56.69 9.75 3741 398868 1212217 108974473
Abortion spontaneous 56.48 9.75 27 402582 34255 110152435
Product dose omission in error 56.33 9.75 9 402600 23503 110163187
Narcotic bowel syndrome 56.10 9.75 25 402584 254 110186436
Myocardial infarction 55.99 9.75 439 402170 191644 109995046
Radiculopathy 55.69 9.75 176 402433 19160 110167530
Intestinal obstruction 55.56 9.75 358 402251 52869 110133821
Eczema 55.53 9.75 112 402497 72181 110114509
Transplant rejection 55.39 9.75 11 402598 24556 110162134
Neutropenia 55.27 9.75 995 401614 373625 109813065
Drug-induced liver injury 55.09 9.75 237 402372 119830 110066860
Back pain 54.94 9.75 1753 400856 369243 109817447
Affect lability 54.93 9.75 171 402438 18466 110168224
Dysarthria 54.88 9.75 507 402102 83614 110103076
Dry skin 54.76 9.75 204 402405 107449 110079241
Amnestic disorder 54.48 9.75 34 402575 716 110185974
Toxic leukoencephalopathy 54.46 9.75 46 402563 1571 110185119
Syncope 54.44 9.75 473 402136 202063 109984627
Neuroblastoma recurrent 53.72 9.75 30 402579 510 110186180
Dilatation intrahepatic duct acquired 53.26 9.75 35 402574 808 110185882
Full blood count abnormal 53.02 9.75 76 402533 55976 110130714
Progressive multifocal leukoencephalopathy 52.59 9.75 13 402596 24943 110161747
Allodynia 51.89 9.75 50 402559 2033 110184657
Post procedural complication 51.50 9.75 213 402396 26445 110160245
Impaired work ability 51.49 9.75 16 402593 26403 110160287
Cough 51.46 9.75 1283 401326 460358 109726332
Hepatic function abnormal 50.99 9.75 161 402448 89134 110097556
Intestinal pseudo-obstruction 50.92 9.75 62 402547 3294 110183396
Restlessness 50.74 9.75 365 402244 55894 110130796
Hemiplegia 50.45 9.75 190 402419 22592 110164098
Disease recurrence 50.34 9.75 90 402519 60694 110125996
Hepatic cirrhosis 50.03 9.75 419 402190 67207 110119483
Sickle cell anaemia with crisis 49.23 9.75 108 402501 9437 110177253
Spinal cord compression 49.06 9.75 94 402515 7458 110179232
Food allergy 48.94 9.75 172 402437 19776 110166914
Vaginal flatulence 48.10 9.75 124 402485 12020 110174670
Tachycardia 48.07 9.75 1122 401487 225523 109961167
Disorientation 47.66 9.75 429 402180 70242 110116448
Product label confusion 47.42 9.75 12 402597 22665 110164025
Joint swelling 47.42 9.75 1238 401371 441607 109745083
Renal impairment 47.20 9.75 448 402161 187997 109998693
Visceral congestion 46.82 9.75 39 402570 1306 110185384
Pneumonia aspiration 46.81 9.75 477 402132 80756 110105934
Atrial fibrillation 46.65 9.75 573 402036 229069 109957621
Hypoxic-ischaemic encephalopathy 46.65 9.75 101 402508 8746 110177944
Interstitial lung disease 46.65 9.75 306 402303 139028 110047662
Pupillary reflex impaired 46.61 9.75 65 402544 3950 110182740
Cyanosis 46.41 9.75 223 402386 29518 110157172
Eye pain 46.34 9.75 69 402540 50030 110136660
Sinusitis 46.32 9.75 780 401829 295908 109890782
Substance use 45.90 9.75 51 402558 2455 110184235
Hypogonadism male 45.78 9.75 20 402589 193 110186497
Hallucination, visual 45.48 9.75 273 402336 39332 110147358
Female genital tract fistula 45.43 9.75 148 402461 16371 110170319
Cardiac failure 45.33 9.75 450 402159 187176 109999514
Blood cholesterol increased 45.14 9.75 442 402167 184343 110002347
Delusion of grandeur 44.89 9.75 48 402561 2212 110184478
Cancer pain 44.86 9.75 85 402524 6687 110180003
Blood pH decreased 44.67 9.75 69 402540 4600 110182090
Loss of personal independence in daily activities 44.59 9.75 341 402268 149679 110037011
Gastrointestinal disorder 44.27 9.75 617 401992 241335 109945355
Laryngitis 44.11 9.75 285 402324 42126 110144564
Cytomegalovirus infection reactivation 43.96 9.75 7 402602 18326 110168364
Proctitis 43.31 9.75 148 402461 16779 110169911
Inflammation 43.20 9.75 472 402137 192766 109993924
Facet joint syndrome 42.68 9.75 194 402415 96634 110090056
Fibromyalgia 42.51 9.75 407 402202 170502 110016188
Lupus vulgaris 42.45 9.75 239 402370 33644 110153046
Arthritis 42.37 9.75 851 401758 166735 110019955
Eating disorder 42.25 9.75 223 402386 30635 110156055
Drug withdrawal syndrome neonatal 42.25 9.75 22 402587 323 110186367
Grip strength 42.21 9.75 99 402510 9042 110177648
Abdominal pain 41.93 9.75 2276 400333 510713 109675977
Paraesthesia 41.86 9.75 731 401878 275790 109910900
Inappropriate schedule of product administration 41.78 9.75 507 402102 203130 109983560
Lupus-like syndrome 41.74 9.75 273 402336 40519 110146171
Serotonin syndrome 40.36 9.75 360 402249 58793 110127897
Appendicolith 40.35 9.75 3 402606 14252 110172438
Cardiac murmur 39.66 9.75 20 402589 24608 110162082
Lip dry 39.23 9.75 209 402400 99874 110086816
Contusion 38.91 9.75 606 402003 232755 109953935
Lymphocyte count abnormal 38.75 9.75 46 402563 2380 110184310
Bronchopulmonary aspergillosis allergic 38.63 9.75 91 402518 8335 110178355
Self-medication 38.57 9.75 76 402533 6156 110180534
Neoplasm progression 38.51 9.75 382 402227 64213 110122477
Accident 38.50 9.75 107 402502 10845 110175845
Night sweats 38.21 9.75 308 402301 133675 110053015
Injection site rash 37.74 9.75 19 402590 23400 110163290
Multiple sclerosis relapse 37.60 9.75 79 402530 50161 110136529
Respiratory tract infection 37.55 9.75 134 402475 71483 110115207
Brain injury 37.30 9.75 121 402488 13355 110173335
Postoperative ileus 37.16 9.75 33 402576 1207 110185483
Sopor 37.15 9.75 47 402562 36499 110150191
Joint range of motion decreased 37.12 9.75 275 402334 121557 110065133
Obliterative bronchiolitis 37.00 9.75 56 402553 3667 110183023
Incoherent 36.95 9.75 89 402520 8269 110178421
Pleuritic pain 36.90 9.75 136 402473 16004 110170686
Contraindicated product administered 36.72 9.75 659 401950 247608 109939082
Creatinine renal clearance increased 36.70 9.75 55 402554 3570 110183120
Nodule 36.36 9.75 39 402570 32592 110154098
Hepatic enzyme increased 36.23 9.75 890 401719 320002 109866688
Transient ischaemic attack 36.08 9.75 116 402493 63866 110122824
Maternal exposure during pregnancy 36.00 9.75 682 401927 254201 109932489
Breakthrough pain 35.85 9.75 36 402573 1540 110185150
Eye pruritus 35.61 9.75 40 402569 32735 110153955
Tenosynovitis 35.26 9.75 8 402601 16275 110170415
Sinus tachycardia 35.25 9.75 280 402329 44213 110142477
Procedural pain 35.17 9.75 236 402373 35329 110151361
Macular degeneration 34.96 9.75 164 402445 21495 110165195
Blood glucose increased 34.90 9.75 311 402298 132185 110054505
Accidental poisoning 34.62 9.75 44 402565 2443 110184247
Abnormal behaviour 34.47 9.75 252 402357 38787 110147903
White blood cell count decreased 34.20 9.75 608 402001 228782 109957908
Hemiparesis 34.08 9.75 275 402334 43628 110143062
Glycosylated haemoglobin increased 34.00 9.75 22 402587 23597 110163093
Pathogen resistance 33.91 9.75 11 402598 17661 110169029
Device difficult to use 33.87 9.75 13 402596 18792 110167898
Small intestinal obstruction 33.83 9.75 217 402392 31996 110154694
Patient uncooperative 33.76 9.75 28 402581 932 110185758
Mydriasis 33.76 9.75 165 402444 21992 110164698
Seronegative arthritis 33.52 9.75 115 402494 13062 110173628
Vascular malformation 33.43 9.75 26 402583 788 110185902
Thrombotic microangiopathy 33.43 9.75 34 402575 29115 110157575
Body temperature increased 33.32 9.75 325 402284 54388 110132302
Drug interaction 33.26 9.75 2179 400430 498004 109688686
Melaena 33.23 9.75 133 402476 68624 110118066
Psoriasis 33.13 9.75 704 401905 139289 110047401
Mechanical ventilation complication 32.48 9.75 25 402584 746 110185944
Throat irritation 32.40 9.75 94 402515 53458 110133232
Dry mouth 32.40 9.75 522 402087 199426 109987264
Diabetes mellitus 32.39 9.75 220 402389 99161 110087529
Sleep disorder 32.38 9.75 518 402091 198126 109988564
Myopathy 32.34 9.75 26 402583 24934 110161756
Soft tissue disorder 32.22 9.75 51 402558 3473 110183217
Vaginal discharge 32.20 9.75 140 402469 17768 110168922
Tonsillar disorder 32.03 9.75 33 402576 1456 110185234
Colorectal cancer metastatic 32.00 9.75 34 402575 1555 110185135
Sleep disorder due to general medical condition, insomnia type 31.93 9.75 239 402370 105404 110081286
Postmortem blood drug level increased 31.81 9.75 30 402579 1187 110185503
Heavy menstrual bleeding 31.73 9.75 10 402599 16355 110170335
Sternal fracture 31.72 9.75 49 402560 3267 110183423
Iron deficiency anaemia 31.65 9.75 41 402568 31518 110155172
Myelodysplastic syndrome 31.49 9.75 55 402554 37429 110149261
Urinary tract infection 31.34 9.75 926 401683 325356 109861334
Hypothermia 31.29 9.75 183 402426 26119 110160571
Diaphragmatic spasm 31.14 9.75 13 402596 111 110186579
Drug tolerance decreased 31.09 9.75 189 402420 27351 110159339
Product used for unknown indication 30.99 9.75 37 402572 1926 110184764
Hypertension 30.98 9.75 1529 401080 508555 109678135
PCO2 increased 30.78 9.75 37 402572 1940 110184750
Wrong technique in product usage process 30.68 9.75 189 402420 87159 110099531
Immunodeficiency 30.54 9.75 244 402365 38594 110148096
Non-small cell lung cancer 30.38 9.75 80 402529 7855 110178835
Abdominal pain upper 30.33 9.75 1004 401605 348107 109838583
Coronary artery disease 30.20 9.75 146 402463 71544 110115146
Neuroblastoma 30.19 9.75 18 402591 348 110186342
Rhythm idioventricular 29.93 9.75 24 402585 761 110185929
Migraine 29.89 9.75 442 402167 171210 110015480
Intentional dose omission 29.88 9.75 18 402591 20062 110166628
Iron deficiency 29.76 9.75 15 402594 18461 110168229
Pain 29.62 9.75 3938 398671 951017 109235673
Pancreatic fibrosis 29.52 9.75 12 402597 95 110186595
Lung cancer metastatic 29.45 9.75 54 402555 4144 110182546
Exposure via skin contact 29.41 9.75 6 402603 13141 110173549
Coma scale abnormal 29.37 9.75 90 402519 9636 110177054
Therapy cessation 29.18 9.75 76 402533 44781 110141909
Suspected suicide 29.01 9.75 121 402488 15078 110171612
Paranasal cyst 28.98 9.75 25 402584 879 110185811
Pathological fracture 28.88 9.75 103 402506 11929 110174761
Hostility 28.87 9.75 42 402567 2654 110184036
Depression 28.66 9.75 908 401701 316427 109870263
Haematotoxicity 28.54 9.75 21 402588 21061 110165629
C-reactive protein abnormal 28.50 9.75 318 402291 129377 110057313
Aspergillus infection 28.12 9.75 31 402578 25585 110161105
Upper respiratory tract infection 28.09 9.75 651 401958 130677 110056013
Vasculitis 28.04 9.75 55 402554 35818 110150872
Granulocytopenia 28.03 9.75 6 402603 12709 110173981
Skin haemorrhage 27.79 9.75 170 402439 24657 110162033
Obesity 27.73 9.75 271 402338 113080 110073610
Multiple-drug resistance 27.68 9.75 7 402602 13228 110173462
Epstein-Barr virus infection 27.60 9.75 17 402592 18721 110167969
Rheumatic fever 27.55 9.75 299 402310 122280 110064410
Skin candida 27.49 9.75 38 402571 2290 110184400
Inspiratory capacity decreased 27.17 9.75 40 402569 2555 110184135
Tendonitis 27.08 9.75 33 402576 26050 110160640
Mitral valve incompetence 27.02 9.75 50 402559 33279 110153411
Cushingoid 26.92 9.75 5 402604 11707 110174983
Injection site bruising 26.82 9.75 96 402513 51167 110135523
Herpes simplex viraemia 26.68 9.75 21 402588 648 110186042
Catheter site granuloma 26.65 9.75 11 402598 91 110186599
Liver injury 26.64 9.75 386 402223 150027 110036663
Euglycaemic diabetic ketoacidosis 26.64 9.75 5 402604 11618 110175072
Carcinoid tumour 26.62 9.75 20 402589 575 110186115
Weaning failure 26.56 9.75 23 402586 813 110185877
Dysphagia 26.55 9.75 740 401869 152860 110033830
Pupil fixed 26.46 9.75 49 402560 3789 110182901
Eye irritation 26.40 9.75 51 402558 33401 110153289
Immune reconstitution inflammatory syndrome 26.40 9.75 13 402596 16213 110170477
Chronic kidney disease 26.32 9.75 166 402443 76125 110110565
Squamous cell carcinoma of skin 26.19 9.75 15 402594 17188 110169502
Adverse reaction 26.18 9.75 42 402567 29552 110157138
Exposure to toxic agent 25.84 9.75 104 402505 12754 110173936
Myocardial fibrosis 25.75 9.75 34 402575 1961 110184729
Low density lipoprotein increased 25.74 9.75 4 402605 10662 110176028
Dependence 25.65 9.75 40 402569 2689 110184001
Rhinalgia 25.64 9.75 49 402560 3880 110182810
Adulterated product 25.57 9.75 26 402583 1129 110185561
Therapy partial responder 25.51 9.75 61 402548 37000 110149690
Ventilation perfusion mismatch 25.47 9.75 22 402587 775 110185915
Anal inflammation 25.46 9.75 38 402571 2458 110184232
Stupor 25.44 9.75 77 402532 8188 110178502
Product storage error 25.31 9.75 25 402584 21703 110164987
Therapeutic response shortened 25.22 9.75 43 402566 29540 110157150
Metastases to bone 25.16 9.75 198 402411 31174 110155516
Anti-cyclic citrullinated peptide antibody 25.13 9.75 141 402468 19823 110166867
Central pain syndrome 24.93 9.75 22 402587 798 110185892
Pulmonary toxicity 24.91 9.75 17 402592 17729 110168961
Anaphylactic reaction 24.88 9.75 568 402041 113732 110072958
Diffuse axonal injury 24.84 9.75 11 402598 110 110186580
Mobility decreased 24.74 9.75 1079 401530 236343 109950347
Intentional self-injury 24.67 9.75 63 402546 37366 110149324
Discomfort 24.63 9.75 594 402015 214113 109972577
Drug dose omission by device 24.58 9.75 11 402598 14505 110172185
Decreased immune responsiveness 24.58 9.75 84 402525 9522 110177168
Paraesthesia oral 24.57 9.75 208 402401 33463 110153227
Implant site extravasation 24.50 9.75 23 402586 905 110185785
Vascular resistance systemic decreased 24.37 9.75 14 402595 252 110186438
Oropharyngeal pain 24.36 9.75 346 402263 134930 110051760
Nephrotic syndrome 24.19 9.75 10 402599 13821 110172869
Uveitis 24.13 9.75 26 402583 21684 110165006
Spinal cord injury 24.04 9.75 30 402579 1635 110185055
Bronchopulmonary aspergillosis 24.03 9.75 45 402564 29818 110156872
Musculoskeletal stiffness 24.00 9.75 806 401803 279016 109907674
Cerebral infarction 23.97 9.75 102 402507 51736 110134954
Acute graft versus host disease in skin 23.82 9.75 5 402604 10735 110175955
Implant site discharge 23.80 9.75 12 402597 164 110186526
Infective pulmonary exacerbation of cystic fibrosis 23.78 9.75 12 402597 14759 110171931
Soft tissue injury 23.71 9.75 35 402574 2241 110184449
Appendicitis 23.70 9.75 42 402567 28422 110158268
Bone marrow failure 23.68 9.75 119 402490 57729 110128961
Total lung capacity decreased 23.54 9.75 68 402541 7046 110179644
Hepatocellular injury 23.52 9.75 285 402324 50357 110136333
Carcinoid crisis 23.39 9.75 18 402591 537 110186153
C-reactive protein 23.28 9.75 47 402562 30284 110156406
Joint effusion 23.28 9.75 25 402584 20880 110165810
Visual analogue scale 23.10 9.75 5 402604 0 110186690
Acute graft versus host disease 23.04 9.75 9 402600 12872 110173818
Red blood cell count decreased 22.97 9.75 143 402466 65780 110120910
Pruritus 22.95 9.75 1814 400795 579746 109606944
Gallbladder cholesterolosis 22.92 9.75 19 402590 632 110186058
Cytopenia 22.83 9.75 47 402562 30069 110156621
Hypogonadism 22.73 9.75 32 402577 1962 110184728
Infusion site granuloma 22.66 9.75 6 402603 8 110186682
COVID-19 pneumonia 22.61 9.75 65 402544 37078 110149612
Vision blurred 22.54 9.75 332 402277 128690 110058000
Suicide attempt 22.52 9.75 254 402355 103140 110083550
Treatment failure 22.51 9.75 804 401805 276430 109910260
Tuberculosis 22.43 9.75 19 402590 17755 110168935
Anaesthetic complication 22.35 9.75 44 402565 3562 110183128
Neuropathy peripheral 22.24 9.75 490 402119 178787 110007903
Drug tolerance increased 22.23 9.75 18 402591 579 110186111
Hepatitis 22.15 9.75 215 402394 89839 110096851
Colitis microscopic 22.04 9.75 102 402507 13292 110173398
Polyarthritis 21.88 9.75 22 402587 18941 110167749
Urine alcohol test positive 21.85 9.75 8 402601 46 110186644
Osteoarthritis 21.84 9.75 502 402107 182121 110004569
Breast cancer female 21.83 9.75 9 402600 12459 110174231
Surgery 21.80 9.75 77 402532 41206 110145484
Squamous cell carcinoma 21.79 9.75 21 402588 18442 110168248
Blood calcium increased 21.78 9.75 126 402483 17914 110168776
Occupational dermatitis 21.71 9.75 11 402598 152 110186538
Oral candidiasis 21.71 9.75 254 402355 44506 110142184
Acute respiratory failure 21.70 9.75 390 402219 74870 110111820
Blood alkaline phosphatase increased 21.67 9.75 371 402238 70564 110116126
Screaming 21.61 9.75 52 402557 4829 110181861
Rhinitis allergic 21.60 9.75 20 402589 17902 110168788
Terminal state 21.56 9.75 57 402552 5610 110181080
Salivary hypersecretion 21.52 9.75 19 402590 17402 110169288
Theft 21.51 9.75 13 402596 258 110186432
Wrong product administered 21.51 9.75 88 402521 10872 110175818
Immunosuppressant drug level increased 21.29 9.75 8 402601 11716 110174974
Renal disorder 21.29 9.75 100 402509 49379 110137311
Spinal epidural haemorrhage 21.27 9.75 14 402595 324 110186366
Hypogammaglobulinaemia 21.27 9.75 25 402584 20051 110166639
Clonus 21.25 9.75 75 402534 8641 110178049
Congenital coronary artery malformation 21.20 9.75 10 402599 117 110186573
Cytomegalovirus viraemia 21.20 9.75 20 402589 17744 110168946
Upper-airway cough syndrome 21.20 9.75 16 402593 15841 110170849
Apnoeic attack 21.19 9.75 20 402589 792 110185898
Illness 21.15 9.75 194 402415 81977 110104713
Substance dependence 21.14 9.75 19 402590 706 110185984
Sinobronchitis 21.12 9.75 16 402593 466 110186224
Nervous system disorder 21.10 9.75 192 402417 31529 110155161
Chronic sinusitis 21.05 9.75 160 402449 24924 110161766
Failure to suspend medication 21.00 9.75 16 402593 470 110186220
Proteinuria 20.90 9.75 75 402534 39943 110146747
Haemophagocytic lymphohistiocytosis 20.89 9.75 53 402556 31506 110155184
SARS-CoV-2 test negative 20.85 9.75 32 402577 2121 110184569
Libido increased 20.84 9.75 35 402574 2504 110184186
Hypoaesthesia 20.83 9.75 933 401676 313290 109873400
Feeling jittery 20.81 9.75 14 402595 14708 110171982
Increased bronchial secretion 20.73 9.75 45 402564 3903 110182787
Systemic mastocytosis 20.72 9.75 14 402595 339 110186351
Product name confusion 20.69 9.75 12 402597 220 110186470
Exercise tolerance decreased 20.66 9.75 9 402600 12058 110174632
Leukoencephalopathy 20.62 9.75 77 402532 9118 110177572
Polyneuropathy in malignant disease 20.57 9.75 16 402593 485 110186205
Chemical poisoning 20.57 9.75 11 402598 171 110186519
Blood uric acid increased 20.55 9.75 29 402580 21500 110165190
Drug level 20.54 9.75 6 402603 14 110186676
Gas poisoning 20.50 9.75 9 402600 88 110186602
Terminal insomnia 20.48 9.75 30 402579 1908 110184782
Sepsis 20.48 9.75 1419 401190 325927 109860763
Sneezing 20.47 9.75 192 402417 31792 110154898
Glomerular filtration rate decreased 20.46 9.75 47 402562 28909 110157781
Neuralgia 20.45 9.75 268 402341 48210 110138480
Alveolitis 20.42 9.75 48 402561 4391 110182299
Affective disorder 20.30 9.75 88 402521 11153 110175537
PO2 decreased 20.22 9.75 39 402570 3109 110183581
Lower respiratory tract infection 20.20 9.75 703 401906 242403 109944287
Administration site erythema 20.19 9.75 15 402594 424 110186266
Nephrolithiasis 20.12 9.75 346 402263 65866 110120824
Carotid artery occlusion 20.12 9.75 5 402604 9560 110177130
Dose calculation error 20.00 9.75 15 402594 430 110186260
Anaesthesia 19.97 9.75 17 402592 587 110186103
Nephropathy toxic 19.90 9.75 44 402565 27434 110159256
Calcium deficiency 19.86 9.75 23 402586 1159 110185531
Aplastic anaemia 19.82 9.75 154 402455 24154 110162536
Neurotoxicity 19.80 9.75 238 402371 41969 110144721
Therapy non-responder 19.78 9.75 429 402180 156878 110029812
Head discomfort 19.77 9.75 24 402585 18976 110167714
Neuroleptic malignant syndrome 19.73 9.75 61 402548 33998 110152692
Hypoacusis 19.70 9.75 64 402545 35127 110151563
Bladder cancer 19.70 9.75 27 402582 20265 110166425
Cardiac failure chronic 19.70 9.75 13 402596 13798 110172892
Optic neuritis 19.59 9.75 8 402601 11139 110175551
Product selection error 19.53 9.75 15 402594 446 110186244
Cutaneous vasculitis 19.52 9.75 11 402598 12718 110173972
Sepsis neonatal 19.41 9.75 9 402600 101 110186589
Peripheral venous disease 19.38 9.75 204 402405 83913 110102777
Obstructive defaecation 19.34 9.75 12 402597 250 110186440
Dyslipidaemia 19.03 9.75 18 402591 15947 110170743
Administration site abscess 18.99 9.75 6 402603 20 110186670
Post-traumatic neck syndrome 18.99 9.75 34 402575 2561 110184129
Breast cancer 18.97 9.75 74 402535 38468 110148222
Ileus 18.94 9.75 183 402426 30546 110156144
Pulseless electrical activity 18.92 9.75 115 402494 16642 110170048
Antinuclear antibody positive 18.89 9.75 5 402604 9163 110177527
Incorrect route of product administration 18.83 9.75 333 402276 63728 110122962
Enthesopathy 18.83 9.75 11 402598 12467 110174223
Pulmonary tuberculosis 18.80 9.75 5 402604 9134 110177556
Gout 18.78 9.75 69 402540 36497 110150193
Buttock injury 18.76 9.75 11 402598 206 110186484
Epidural haemorrhage 18.74 9.75 14 402595 399 110186291
Splenic injury 18.73 9.75 12 402597 265 110186425
Ischaemic stroke 18.59 9.75 82 402527 41181 110145509
Breath sounds abnormal 18.57 9.75 157 402452 25247 110161443
Hyperreflexia 18.49 9.75 76 402533 9409 110177281
Hypomania 18.48 9.75 7 402602 10203 110176487
Femur fracture 18.48 9.75 91 402518 44378 110142312
Burns second degree 18.44 9.75 3 402606 7730 110178960
Chronic spontaneous urticaria 18.44 9.75 29 402580 1964 110184726
Brain hypoxia 18.35 9.75 23 402586 1259 110185431
Metastasis 18.35 9.75 69 402540 8198 110178492
Drug detoxification 18.32 9.75 16 402593 572 110186118
Lactic acidosis 18.30 9.75 233 402376 92578 110094112
Biliary obstruction 18.27 9.75 53 402556 5505 110181185
Transplant dysfunction 18.22 9.75 4 402605 8324 110178366
Pancreatic neuroendocrine tumour metastatic 18.21 9.75 11 402598 218 110186472
Gastrointestinal stoma output abnormal 18.18 9.75 14 402595 418 110186272
Nail bed inflammation 18.04 9.75 29 402580 2001 110184689
Productive cough 17.98 9.75 300 402309 114005 110072685
Administration site discharge 17.95 9.75 6 402603 25 110186665
Stoma site dermatitis 17.89 9.75 12 402597 287 110186403
Demyelination 17.86 9.75 6 402603 9423 110177267
Rheumatic disorder 17.81 9.75 40 402569 3551 110183139
Aspiration bone marrow 17.81 9.75 10 402599 172 110186518
Proctalgia 17.72 9.75 95 402514 13127 110173563
Visual acuity reduced 17.67 9.75 59 402550 32114 110154576
Urticaria thermal 17.67 9.75 15 402594 516 110186174
Bradykinesia 17.64 9.75 82 402527 10706 110175984
Intestinal intraepithelial lymphocytes increased 17.61 9.75 11 402598 232 110186458
Device failure 17.56 9.75 62 402547 7145 110179545
Hypersensitivity 17.53 9.75 1250 401359 402748 109783942
Nephropathy 17.48 9.75 14 402595 13453 110173237
Kidney transplant rejection 17.48 9.75 11 402598 11976 110174714
Paraparesis 17.45 9.75 46 402563 4520 110182170
Pneumocystis jirovecii pneumonia 17.44 9.75 88 402521 42647 110144043
Pemphigoid 17.40 9.75 28 402581 19679 110167011
Treatment noncompliance 17.23 9.75 176 402433 72814 110113876
Respiratory tract congestion 17.20 9.75 180 402429 30677 110156013
Pelvic pain 17.11 9.75 108 402501 15834 110170856
Aphasia 17.10 9.75 306 402303 58691 110127999
Product administration interrupted 16.97 9.75 10 402599 11282 110175408
Dry eye 16.96 9.75 126 402483 55667 110131023
Tumour pain 16.95 9.75 35 402574 2932 110183758
Basal cell carcinoma 16.93 9.75 96 402513 45174 110141516
Skin cancer 16.93 9.75 24 402585 17760 110168930
Photosensitivity reaction 16.92 9.75 43 402566 25546 110161144
Neck pain 16.90 9.75 331 402278 122799 110063891
Sinus disorder 16.90 9.75 188 402421 32540 110154150
Injection site discolouration 16.89 9.75 6 402603 9097 110177593
Foetal monitoring abnormal 16.84 9.75 10 402599 192 110186498
Cerebrospinal fluid leakage 16.83 9.75 29 402580 2119 110184571
Victim of homicide 16.81 9.75 11 402598 252 110186438
Lymphoproliferative disorder 16.77 9.75 3 402606 7215 110179475
Tension headache 16.75 9.75 7 402602 9611 110177079
Hepatitis B 16.73 9.75 7 402602 9605 110177085
Cutaneous T-cell lymphoma stage I 16.71 9.75 9 402600 142 110186548
Metastases to spine 16.66 9.75 50 402559 5293 110181397
Subarachnoid haemorrhage 16.64 9.75 54 402555 29648 110157042
Injection site urticaria 16.62 9.75 23 402586 17192 110169498
Rash pruritic 16.56 9.75 254 402355 97815 110088875
Parkinsonism 16.51 9.75 35 402574 22152 110164538
Growth hormone-producing pituitary tumour 16.49 9.75 9 402600 146 110186544
Administration site odour 16.46 9.75 6 402603 34 110186656
Liver disorder 16.45 9.75 393 402216 141850 110044840
Psychotic behaviour 16.44 9.75 23 402586 1402 110185288
Neurological examination abnormal 16.37 9.75 17 402592 757 110185933
Product monitoring error 16.36 9.75 6 402603 8921 110177769
Mastoiditis 16.35 9.75 32 402577 2579 110184111
Drug reaction with eosinophilia and systemic symptoms 16.22 9.75 206 402403 81889 110104801
Faecal volume decreased 16.22 9.75 13 402596 412 110186278
Post lumbar puncture syndrome 16.21 9.75 20 402589 1077 110185613
Rebound effect 16.16 9.75 18 402591 14788 110171902
Asthenia 16.15 9.75 2230 400379 686769 109499921
Diplopia 16.13 9.75 88 402521 41806 110144884
Complication of device insertion 16.10 9.75 6 402603 8832 110177858
Blood pH increased 16.08 9.75 23 402586 1431 110185259
Red blood cell sedimentation rate increased 16.08 9.75 386 402223 77916 110108774
Fungating wound 16.07 9.75 7 402602 67 110186623
Product prescribing error 16.05 9.75 115 402494 51216 110135474
Anxiety 16.05 9.75 1462 401147 343616 109843074
Adverse event 16.02 9.75 289 402320 108520 110078170
Vascular device infection 15.98 9.75 109 402500 16403 110170287
Central nervous system injury 15.96 9.75 9 402600 156 110186534
Device issue 15.94 9.75 68 402541 34467 110152223
Basal ganglion degeneration 15.93 9.75 13 402596 423 110186267
Alanine aminotransferase abnormal 15.92 9.75 7 402602 9327 110177363
Iodine allergy 15.92 9.75 16 402593 685 110186005
Malignant melanoma 15.88 9.75 23 402586 16868 110169822
Injection site induration 15.85 9.75 11 402598 11372 110175318
Walking aid user 15.79 9.75 150 402459 24925 110161765
Muscle tension dysphonia 15.77 9.75 11 402598 281 110186409
Paradoxical drug reaction 15.77 9.75 8 402601 9809 110176881
Intentional misuse of drug delivery system 15.75 9.75 5 402604 17 110186673
Sinus congestion 15.74 9.75 175 402434 30284 110156406
Haematochezia 15.72 9.75 311 402298 115213 110071477
Drug effective for unapproved indication 15.71 9.75 17 402592 14150 110172540
Hepatic pain 15.68 9.75 45 402564 4645 110182045
Muscle spasms 15.67 9.75 840 401769 277317 109909373
Ulcer haemorrhage 15.65 9.75 37 402572 22534 110164156
Neuroendocrine tumour of the lung 15.64 9.75 6 402603 40 110186650
Amenorrhoea 15.63 9.75 7 402602 9224 110177466
Nocardiosis 15.58 9.75 4 402605 7482 110179208
Epidural analgesia 15.57 9.75 9 402600 164 110186526
Blood loss anaemia 15.55 9.75 26 402583 17999 110168691
Parathyroid hormone-related protein abnormal 15.53 9.75 5 402604 18 110186672
Nasal mucosal disorder 15.52 9.75 26 402583 1857 110184833
Peripheral nerve injury 15.49 9.75 20 402589 1128 110185562
Breast cancer stage III 15.46 9.75 199 402410 78918 110107772
Urticaria 15.43 9.75 977 401632 317880 109868810
Diabetes mellitus inadequate control 15.42 9.75 56 402553 29719 110156971
Administration site induration 15.39 9.75 6 402603 42 110186648
Administration site haemorrhage 15.39 9.75 6 402603 42 110186648
Oesophagitis chemical 15.38 9.75 7 402602 75 110186615
Anorgasmia 15.29 9.75 24 402585 1622 110185068
Device use error 15.22 9.75 7 402602 9082 110177608
Infusion site pain 15.15 9.75 25 402584 17394 110169296
Metastases to central nervous system 15.12 9.75 138 402471 22679 110164011
Tinnitus 15.12 9.75 144 402465 60396 110126294
Haematuria 15.05 9.75 212 402397 82793 110103897
Internal haemorrhage 15.02 9.75 9 402600 10062 110176628
Oesophageal carcinoma 14.94 9.75 12 402597 11512 110175178
Non-obstructive cardiomyopathy 14.93 9.75 5 402604 21 110186669
Ileus paralytic 14.84 9.75 83 402526 11654 110175036
Agonal death struggle 14.83 9.75 4 402605 6 110186684
Gastrointestinal hypomotility 14.82 9.75 30 402579 2478 110184212
Large intestine polyp 14.79 9.75 20 402589 15097 110171593
Porphyria acute 14.77 9.75 118 402491 18662 110168028
Breast cancer metastatic 14.76 9.75 80 402529 11101 110175589
Chronic graft versus host disease 14.75 9.75 8 402601 9449 110177241
Joint destruction 14.68 9.75 11 402598 10932 110175758
Head injury 14.63 9.75 94 402515 42923 110143767
Blood immunoglobulin A decreased 14.63 9.75 28 402581 2220 110184470
Device toxicity 14.57 9.75 5 402604 23 110186667
Infection 14.54 9.75 1128 401481 361072 109825618
Gastrointestinal stoma complication 14.52 9.75 35 402574 3254 110183436
Pulmonary haemorrhage 14.40 9.75 106 402503 16350 110170340
Incubator therapy 14.39 9.75 6 402603 51 110186639
Cardiopulmonary failure 14.37 9.75 62 402547 7841 110178849
Ear infection 14.36 9.75 314 402295 62418 110124272
Pregnancy 14.28 9.75 118 402491 50949 110135741
Osteoporosis 14.26 9.75 417 402192 86735 110099955
BK virus infection 14.23 9.75 16 402593 13090 110173600
Spondylitis 14.22 9.75 80 402529 11258 110175432
Faecaloma 14.19 9.75 98 402511 14810 110171880
Factitious disorder 14.16 9.75 9 402600 196 110186494
Actinic keratosis 14.12 9.75 4 402605 7009 110179681
Temperature intolerance 14.12 9.75 18 402591 13932 110172758
Pain in extremity 14.10 9.75 1555 401054 485563 109701127
Prescription drug used without a prescription 14.01 9.75 48 402561 5448 110181242
Hypothyroidism 14.01 9.75 184 402425 72715 110113975
Labelled drug-drug interaction medication error 13.96 9.75 57 402552 29245 110157445
Myoglobin urine 13.91 9.75 5 402604 27 110186663
Microvillous inclusion disease 13.89 9.75 10 402599 269 110186421
Brain death 13.88 9.75 54 402555 6519 110180171
Emphysema 13.87 9.75 121 402488 19635 110167055
Mucosal inflammation 13.87 9.75 453 402156 95688 110091002
Femoral pulse abnormal 13.86 9.75 3 402606 0 110186690
Dislocation of vertebra 13.84 9.75 230 402379 43491 110143199
Blood phosphorus decreased 13.84 9.75 60 402549 7605 110179085
Anosmia 13.79 9.75 15 402594 12457 110174233
Scan gallium abnormal 13.76 9.75 5 402604 28 110186662
Haemorrhagic stroke 13.74 9.75 18 402591 13771 110172919
Foetal arrhythmia 13.72 9.75 6 402603 58 110186632
Acne 13.69 9.75 69 402540 33451 110153239
Medical device site infection 13.63 9.75 15 402594 714 110185976
Gastrointestinal bacterial infection 13.63 9.75 21 402588 1397 110185293
Blood chromogranin A increased 13.57 9.75 15 402594 718 110185972
Cholestatic liver injury 13.52 9.75 58 402551 7318 110179372
Drug tolerance 13.48 9.75 105 402504 16480 110170210
Retinal haemorrhage 13.47 9.75 9 402600 9492 110177198
Hyponatraemia 13.46 9.75 651 401958 217002 109969688
Disease prodromal stage 13.46 9.75 6 402603 61 110186629
Eosinophil count increased 13.45 9.75 36 402573 21022 110165668
Shunt malfunction 13.45 9.75 11 402598 359 110186331
Tooth injury 13.43 9.75 27 402582 2219 110184471
Thirst decreased 13.42 9.75 11 402598 360 110186330
Cheyne-Stokes respiration 13.40 9.75 13 402596 533 110186157
Skin fissures 13.33 9.75 45 402564 24413 110162277
Rhinitis 13.33 9.75 40 402569 22505 110164185
Inflammatory marker increased 13.31 9.75 20 402589 14449 110172241
Electroencephalogram abnormal 13.27 9.75 51 402558 6122 110180568
Colitis 13.22 9.75 476 402133 101847 110084843
Gastrointestinal haemorrhage 13.20 9.75 481 402128 165037 110021653
Urinary tract stoma complication 13.19 9.75 7 402602 107 110186583
Eosinophil cationic protein increased 13.13 9.75 6 402603 65 110186625
Ear pruritus 13.11 9.75 5 402604 7255 110179435
PO2 abnormal 13.08 9.75 5 402604 33 110186657
Post stroke epilepsy 13.08 9.75 5 402604 33 110186657
Infusion site reaction 13.07 9.75 28 402581 17654 110169036
Joint stiffness 13.07 9.75 329 402280 66914 110119776
Pleural effusion 13.04 9.75 781 401828 176928 110009762
5-hydroxyindolacetic acid 12.98 9.75 4 402605 12 110186678
Mitochondrial encephalomyopathy 12.97 9.75 7 402602 111 110186579
Tricuspid valve incompetence 12.96 9.75 44 402565 23829 110162861
Rash macular 12.92 9.75 85 402524 38601 110148089
Infusion related reaction 12.91 9.75 1203 401406 379959 109806731
Anaemia of malignant disease 12.89 9.75 17 402592 979 110185711
Cryptitis 12.87 9.75 11 402598 382 110186308
Infrequent bowel movements 12.83 9.75 26 402583 2149 110184541
Pancreatitis 12.80 9.75 438 402171 93095 110093595
Live birth 12.76 9.75 177 402432 69307 110117383
Drug level above therapeutic 12.75 9.75 79 402530 11509 110175181
Eosinophilia 12.74 9.75 142 402467 57794 110128896
Akathisia 12.73 9.75 27 402582 17086 110169604
Cytomegalovirus chorioretinitis 12.72 9.75 5 402604 7123 110179567
Probiotic therapy 12.71 9.75 8 402601 171 110186519
Retrograde amnesia 12.70 9.75 15 402594 772 110185918
Injection site extravasation 12.67 9.75 11 402598 10158 110176532
Consciousness fluctuating 12.66 9.75 26 402583 2170 110184520
Monoplegia 12.63 9.75 43 402566 4866 110181824
Reaction to excipient 12.61 9.75 25 402584 2034 110184656
Pain assessment 12.59 9.75 5 402604 37 110186653
Cardiomyopathy 12.59 9.75 71 402538 33454 110153236
Skin reaction 12.58 9.75 125 402484 21019 110165671
Lymphopenia 12.56 9.75 90 402519 40080 110146610
Wrong rate 12.55 9.75 8 402601 175 110186515
Lung opacity 12.55 9.75 79 402530 11573 110175117
Limb discomfort 12.54 9.75 92 402517 40762 110145928
Cardiac output decreased 12.52 9.75 25 402584 2044 110184646
5-hydroxyindolacetic acid in urine 12.51 9.75 4 402605 14 110186676
Delayed recovery from anaesthesia 12.50 9.75 26 402583 2189 110184501
Hypohidrosis 12.50 9.75 10 402599 316 110186374
Vitreous floaters 12.49 9.75 9 402600 9125 110177565
Spinal fusion surgery 12.42 9.75 66 402543 9090 110177600
Drug eruption 12.41 9.75 130 402479 53529 110133161
Blood triglycerides increased 12.39 9.75 45 402564 23881 110162809
Logorrhoea 12.38 9.75 43 402566 4914 110181776
Visceral oedema 12.37 9.75 6 402603 75 110186615
Immunisation reaction 12.36 9.75 15 402594 794 110185896
Diabetic ketoacidosis 12.30 9.75 96 402513 41962 110144728
Tardive dyskinesia 12.27 9.75 19 402590 13560 110173130
Antasthmatic drug level 12.26 9.75 5 402604 40 110186650
Medical device site erythema 12.23 9.75 6 402603 77 110186613
Abortion induced 12.20 9.75 7 402602 8012 110178678
Metastases to eye 12.18 9.75 10 402599 328 110186362
Angina unstable 12.16 9.75 26 402583 16406 110170284
Intraocular pressure increased 12.12 9.75 13 402596 10863 110175827
Loss of consciousness 12.10 9.75 850 401759 195456 109991234
Red cell distribution width increased 12.09 9.75 29 402580 17573 110169117
Vertigo 12.08 9.75 233 402376 86637 110100053
Normochromic normocytic anaemia 12.06 9.75 18 402591 13039 110173651
Phlebitis 12.05 9.75 69 402540 9772 110176918
Electrocardiogram low voltage 12.05 9.75 5 402604 42 110186648
Skin papilloma 12.04 9.75 5 402604 6891 110179799
Fear-related avoidance of activities 12.04 9.75 7 402602 129 110186561
Respiratory rate increased 12.01 9.75 142 402467 24941 110161749
Cardiac pacemaker insertion 11.95 9.75 4 402605 6297 110180393
Sarcoidosis 11.95 9.75 17 402592 12562 110174128
Bladder dilatation 11.91 9.75 27 402582 2412 110184278
Tachyphylaxis 11.90 9.75 11 402598 424 110186266
Acute pulmonary oedema 11.88 9.75 104 402505 16892 110169798
Organising pneumonia 11.87 9.75 21 402588 14222 110172468
Excessive eye blinking 11.81 9.75 23 402586 1847 110184843
Status epilepticus 11.78 9.75 67 402542 31504 110155186
Nerve injury 11.76 9.75 73 402536 10640 110176050
Analgesic drug level 11.75 9.75 5 402604 45 110186645
Stroke volume increased 11.72 9.75 4 402605 18 110186672
Gastrointestinal motility disorder 11.67 9.75 55 402554 7221 110179469
Pocket erosion 11.65 9.75 5 402604 46 110186644
Failure to thrive 11.63 9.75 87 402522 13487 110173203
Pneumonia viral 11.62 9.75 75 402534 11082 110175608
Immune-mediated myositis 11.61 9.75 4 402605 6182 110180508
Vestibular disorder 11.61 9.75 28 402581 2604 110184086
Spinal cord infarction 11.61 9.75 17 402592 1081 110185609
Muscle twitching 11.61 9.75 163 402446 29772 110156918
Genital haemorrhage 11.51 9.75 6 402603 7246 110179444
Graft versus host disease in skin 11.46 9.75 8 402601 8246 110178444
Blood immunoglobulin M increased 11.41 9.75 21 402588 1616 110185074
Phyllodes tumour 11.41 9.75 6 402603 90 110186600
Septic necrosis 11.41 9.75 6 402603 90 110186600
Injection site cyst 11.40 9.75 7 402602 143 110186547
Fungal infection 11.38 9.75 124 402485 50682 110136008
Synovial cyst 11.31 9.75 15 402594 11415 110175275
Antinuclear antibody negative 11.28 9.75 7 402602 146 110186544
Concomitant disease aggravated 11.21 9.75 27 402582 16337 110170353
General physical condition abnormal 11.19 9.75 56 402553 7534 110179156
Coronary artery bypass 11.18 9.75 4 402605 6038 110180652
Hallucination, tactile 11.14 9.75 16 402593 999 110185691
Underweight 11.14 9.75 20 402589 1510 110185180
Renal function test abnormal 11.14 9.75 63 402546 8883 110177807
Adjustment disorder with depressed mood 11.14 9.75 223 402386 43660 110143030
Foetal heart rate abnormal 11.11 9.75 13 402596 662 110186028
Coronavirus infection 11.10 9.75 11 402598 9534 110177156
Increased tendency to bruise 11.06 9.75 16 402593 11742 110174948
Regressive behaviour 11.05 9.75 8 402601 217 110186473
Anal erythema 11.05 9.75 9 402600 292 110186398
Pain in jaw 11.03 9.75 126 402483 51051 110135639
Hyperthyroidism 10.97 9.75 62 402547 29199 110157491
Acute myocardial infarction 10.96 9.75 227 402382 83550 110103140
Decerebration 10.96 9.75 6 402603 98 110186592
Pruritus genital 10.96 9.75 5 402604 6517 110180173
Gastric hypomotility 10.94 9.75 9 402600 296 110186394
Catheter site phlebitis 10.92 9.75 4 402605 23 110186667
Stoma site inflammation 10.91 9.75 16 402593 1019 110185671
Pancytopenia 10.89 9.75 638 401971 208975 109977715
Hepatic cytolysis 10.89 9.75 270 402339 54783 110131907
Hyperlipidaemia 10.88 9.75 81 402528 35767 110150923
Bacterial infection 10.87 9.75 111 402498 45925 110140765
Blood creatine phosphokinase MB increased 10.84 9.75 29 402580 2874 110183816
Alkalosis 10.81 9.75 14 402595 792 110185898
Bezold-Jarisch reflex 10.79 9.75 5 402604 56 110186634
Infusion site extravasation 10.78 9.75 16 402593 11618 110175072
Convulsive threshold lowered 10.78 9.75 16 402593 1030 110185660
Distributive shock 10.77 9.75 4 402605 5900 110180790
Hyperuricaemia 10.75 9.75 23 402586 14508 110172182
Optic nerve operation 10.72 9.75 11 402598 483 110186207
Adiposis dolorosa 10.71 9.75 9 402600 305 110186385
Peripheral ischaemia 10.71 9.75 73 402536 10985 110175705
Lung transplant 10.67 9.75 3 402606 5283 110181407
Graft versus host disease 10.67 9.75 34 402575 18772 110167918
Keratitis 10.65 9.75 42 402567 5102 110181588
Anamnestic reaction 10.64 9.75 5 402604 58 110186632
Anorectal malformation 10.64 9.75 5 402604 58 110186632
Foetal megacystis 10.58 9.75 3 402606 6 110186684
Diarrhoea haemorrhagic 10.56 9.75 26 402583 15613 110171077
Acute generalised exanthematous pustulosis 10.53 9.75 123 402486 21541 110165149
Arrhythmia 10.49 9.75 184 402425 69391 110117299
Subdural effusion 10.49 9.75 6 402603 107 110186583
Aortic valve stenosis 10.46 9.75 5 402604 6345 110180345
Menstruation irregular 10.45 9.75 4 402605 5793 110180897
Angina pectoris 10.45 9.75 299 402310 61996 110124694
Analgesic drug level above therapeutic 10.45 9.75 11 402598 498 110186192
Blood pressure abnormal 10.44 9.75 44 402565 22380 110164310
Cluster headache 10.39 9.75 17 402592 1190 110185500
Oedema 10.39 9.75 642 401967 209334 109977356
Dyschezia 10.37 9.75 34 402575 3773 110182917
Skin disorder 10.32 9.75 103 402506 42810 110143880
Foot operation 10.27 9.75 7 402602 7306 110179384
Lung disorder 10.27 9.75 543 402066 179504 110007186
Dysgeusia 10.26 9.75 186 402423 69799 110116891
Prescribed overdose 10.25 9.75 403 402206 87178 110099512
Atrioventricular block complete 10.25 9.75 38 402571 20044 110166646
Peritonitis bacterial 10.24 9.75 14 402595 10519 110176171
Disseminated tuberculosis 10.24 9.75 3 402606 5143 110181547
Bone pain 10.21 9.75 310 402299 64823 110121867
Intrapericardial thrombosis 10.21 9.75 5 402604 64 110186626
Agitation postoperative 10.21 9.75 5 402604 64 110186626
Tongue oedema 10.20 9.75 9 402600 8247 110178443
Swollen tongue 10.20 9.75 290 402319 60072 110126618
Suicidal ideation 10.19 9.75 262 402347 93675 110093015
Nasal dryness 10.18 9.75 4 402605 5702 110180988
Rhinovirus infection 10.18 9.75 17 402592 11772 110174918
Abdominal compartment syndrome 10.16 9.75 22 402587 1905 110184785
Pseudomonal sepsis 10.16 9.75 62 402547 8984 110177706
Device computer issue 10.16 9.75 6 402603 114 110186576
Immunosuppression 10.15 9.75 32 402577 17727 110168963
Flushing 10.10 9.75 297 402312 104439 110082251
Kidney congestion 10.09 9.75 11 402598 518 110186172
Depressed mood 10.09 9.75 158 402451 60651 110126039
Neurogenic bowel 10.09 9.75 9 402600 331 110186359
End stage renal disease 10.08 9.75 42 402567 21431 110165259
Inflammatory bowel disease 10.06 9.75 7 402602 7227 110179463
Stent placement 10.06 9.75 7 402602 7227 110179463
Product preparation error 10.04 9.75 15 402594 10864 110175826
Pulse absent 10.03 9.75 73 402536 11219 110175471
Fibrinolysis 10.00 9.75 5 402604 67 110186623
Postmortem blood drug level abnormal 10.00 9.75 12 402597 628 110186062
Febrile neutropenia 9.98 9.75 1308 401301 315459 109871231
Dehydration 9.96 9.75 1163 401446 278348 109908342
Laryngectomy 9.91 9.75 4 402605 31 110186659
Needle issue 9.91 9.75 104 402505 17736 110168954
Angiopathy 9.91 9.75 60 402549 8670 110178020
Dehiscence 9.91 9.75 13 402596 745 110185945
Viral infection 9.89 9.75 135 402474 53004 110133686
Stoma site pain 9.88 9.75 22 402587 1941 110184749
Disease progression 9.88 9.75 1024 401585 243010 109943680
Pharyngitis streptococcal 9.83 9.75 21 402588 13256 110173434
Mediastinal shift 9.81 9.75 5 402604 70 110186620
Cardiac index increased 9.81 9.75 4 402605 32 110186658
Rheumatoid arthritis 9.80 9.75 1240 401369 298373 109888317
Conjunctival haemorrhage 9.79 9.75 6 402603 6627 110180063
Haemorrhoidal haemorrhage 9.79 9.75 9 402600 8084 110178606
Incision site swelling 9.78 9.75 9 402600 345 110186345
Cross sensitivity reaction 9.78 9.75 4 402605 5563 110181127
Prothrombin time prolonged 9.77 9.75 101 402508 17160 110169530

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07DA52 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
ANTIPROPULSIVES
Antipropulsives
ATC N02AA01 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA51 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AG01 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with antispasmodics
ATC R05DA05 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Opium alkaloids and derivatives
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018689 Sensory System Agents
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
CHEBI has role CHEBI:35482 opioid analgesic
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:38867 anaesthetic
CHEBI has role CHEBI:55322 ฮผ-opioid receptor agonist
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

A07DA Antipropulsives 5 drugs
difenoxindiphenoxylateeluxadolineloperamideloperamide oxide
N02AA Natural opium alkaloids 8 drugs
codeinedihydrocodeinehydromorphonenaloxonenaltrexonenicomorphineoxycodoneoxymorphone
N02AG Opioids in combination with antispasmodics 3 drugs
hydromorphoneketobemidonepethidine
R05DA Opium alkaloids and derivatives 10 drugs
acetyldihydrocodeinecodeinedextromethorphandimemorfanethylmorphinehydrocodonenormethadonenoscapinepholcodinethebacon

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
General anesthesia indication 50697003
Diarrhea indication 62315008
Severe pain indication 76948002
Chronic pain indication 82423001
Local anesthesia indication 386761002
Acute postoperative pain indication 107401000119105
Regional Anesthesia for Surgery indication
Regional Anesthesia for Labor Pain indication
Chronic Pain with Opioid Tolerance indication
Neuropathic pain off-label use 247398009
Neonatal Abstinence Syndrome off-label use 414819007 DOID:9828
Sedation in Intubated Patients off-label use
Neonatal Opioid Dependence off-label use
Brain damage contraindication 2470005
Priapism contraindication 6273006 DOID:9286
Tachyarrhythmia contraindication 6285003
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Dyskinesia contraindication 9748009
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Severe chronic ulcerative colitis contraindication 14311001
Chronic disease of respiratory system contraindication 17097001
Acute vomiting contraindication 23971007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Orthostatic hypotension contraindication 28651003
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Torsades de pointes contraindication 31722008
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Ulcerative colitis contraindication 64766004 DOID:8577
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Pancreatitis contraindication 75694006 DOID:4989
Urethral stricture contraindication 76618002
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of biliary tract contraindication 105997008 DOID:9741
Prolonged QT interval contraindication 111975006
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Hypomagnesemia contraindication 190855004
Alcohol withdrawal syndrome contraindication 191480000
Drug-induced psychosis contraindication 191483003 DOID:1742
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Bladder outflow obstruction contraindication 236645006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Drowsy contraindication 271782001
Primary adrenocortical insufficiency contraindication 373662000
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Chronic lung disease contraindication 413839001
Disorder of coronary artery contraindication 414024009
Central nervous system depression contraindication 418072004
Congenital long QT syndrome contraindication 442917000
Acute exacerbation of asthma contraindication 708038006
Predisposition to Nausea and Vomiting contraindication
Progressive Angina Pectoris contraindication
Severe Nausea contraindication
Pain in Opioid Naive Patients contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.71 acidic
pKa2 8.38 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 7682633 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8158156 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 7682633 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8158156 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 7682633 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8158156 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 7682633 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8158156 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 7682633 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8158156 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 7682633 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8158156 June 19, 2027 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED.
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8623418 Nov. 7, 2029 TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8623418 Nov. 7, 2029 TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8623418 Nov. 7, 2029 TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8623418 Nov. 7, 2029 TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8623418 Nov. 7, 2029 TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** EMBEDA ALPHARMA PHARMS N022321 Aug. 13, 2009 DISCN CAPSULE, EXTENDED RELEASE ORAL 8623418 Nov. 7, 2029 TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED
15MG ARYMO ER ZYLA N208603 Jan. 9, 2017 DISCN TABLET, EXTENDED RELEASE ORAL 9044402 July 1, 2033 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
15MG ARYMO ER ZYLA N208603 Jan. 9, 2017 DISCN TABLET, EXTENDED RELEASE ORAL 9549899 July 1, 2033 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
30MG ARYMO ER ZYLA N208603 Jan. 9, 2017 DISCN TABLET, EXTENDED RELEASE ORAL 9044402 July 1, 2033 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
30MG ARYMO ER ZYLA N208603 Jan. 9, 2017 DISCN TABLET, EXTENDED RELEASE ORAL 9549899 July 1, 2033 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
60MG ARYMO ER ZYLA N208603 Jan. 9, 2017 DISCN TABLET, EXTENDED RELEASE ORAL 9044402 July 1, 2033 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
60MG ARYMO ER ZYLA N208603 Jan. 9, 2017 DISCN TABLET, EXTENDED RELEASE ORAL 9549899 July 1, 2033 MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE
10MG/ML (10MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
10MG/ML (10MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 TREATMENT OF PAIN
2MG/ML (2MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
2MG/ML (2MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 TREATMENT OF PAIN
4MG/ML (4MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
4MG/ML (4MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 RX SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 TREATMENT OF PAIN
5MG/ML (5MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 DISCN SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
5MG/ML (5MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 DISCN SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 TREATMENT OF PAIN
8MG/ML (8MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 DISCN SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA
8MG/ML (8MG/ML) MORPHINE SULFATE FRESENIUS KABI USA N204223 Oct. 30, 2013 DISCN SOLUTION INTRAMUSCULAR, INTRAVENOUS 9192608 March 12, 2034 TREATMENT OF PAIN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST EC50 7.86 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 6.85 CHEMBL
Kappa-type opioid receptor GPCR Ki 6.97 WOMBAT-PK
Delta-type opioid receptor GPCR Ki 6.62 WOMBAT-PK
Solute carrier family 22 member 1 Transporter IC50 4.55 CHEMBL
Mu-type opioid receptor GPCR Ki 9.11 CHEMBL
Mu-type opioid receptor GPCR Ki 8.92 CHEMBL
Mu-type opioid receptor GPCR Ki 9.06 CHEMBL
Delta-type opioid receptor GPCR Ki 7 CHEMBL
Delta-type opioid receptor GPCR Ki 8.74 CHEMBL
Kappa-type opioid receptor GPCR Ki 7.62 CHEMBL
Kappa-type opioid receptor GPCR Ki 7.57 CHEMBL
Kappa-type opioid receptor GPCR Ki 6.52 CHEMBL
Mu-type opioid receptor GPCR Ki 9.30 CHEMBL
Nociceptin receptor GPCR Ki 7.86 CHEMBL
Opioid receptor GPCR Ki 8.22 CHEMBL
Dopamine receptor GPCR IC50 8.27 CHEMBL
Opioid receptor GPCR IC50 7.57 CHEMBL
Mu opioid receptor-like OR2 GPCR Ki 6.73 CHEMBL
Opioid receptor, delta 1b GPCR Ki 5.85 CHEMBL
Opioid receptor homologue GPCR Ki 6.65 CHEMBL

External reference:

IDSource
D00842 KEGG_DRUG
52-26-6 SECONDARY_CAS_RN
6211-15-0 SECONDARY_CAS_RN
4017470 VANDF
4017530 VANDF
C0026549 UMLSCUI
CHEBI:17303 CHEBI
MOI PDB_CHEM_ID
CHEMBL70 ChEMBL_ID
CHEMBL556578 ChEMBL_ID
CHEMBL2103744 ChEMBL_ID
DB00295 DRUGBANK_ID
D009020 MESH_DESCRIPTOR_UI
5288826 PUBCHEM_CID
1627 IUPHAR_LIGAND_ID
76I7G6D29C UNII
235751 RXNORM
15239 MMSL
18643 MMSL
1913 MMSL
5136 MMSL
d00308 MMSL
d05295 MMSL
001545 NDDF
001546 NDDF
003523 NDDF
373529000 SNOMEDCT_US
395804007 SNOMEDCT_US
414779007 SNOMEDCT_US
60886004 SNOMEDCT_US
73572009 SNOMEDCT_US
76I7G6D29C INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0235 TABLET 15 mg ORAL NDA 32 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0236 TABLET 30 mg ORAL NDA 32 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0237 SOLUTION 10 mg ORAL NDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0238 SOLUTION 20 mg ORAL NDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0404 SOLUTION 100 mg ORAL NDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0517 SOLUTION 100 mg ORAL NDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1277 CAPSULE, EXTENDED RELEASE 20 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1278 CAPSULE, EXTENDED RELEASE 30 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1279 CAPSULE, EXTENDED RELEASE 50 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1280 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1281 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1282 CAPSULE, EXTENDED RELEASE 100 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1479 CAPSULE, EXTENDED RELEASE 40 mg ORAL ANDA 33 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0904 SOLUTION 10 mg ORAL NDA 32 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0121-4955 SOLUTION 10 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-3090 CAPSULE, EXTENDED RELEASE 30 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-3091 CAPSULE, EXTENDED RELEASE 60 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-3092 CAPSULE, EXTENDED RELEASE 90 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-3093 CAPSULE, EXTENDED RELEASE 120 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-3116 CAPSULE, EXTENDED RELEASE 45 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-3117 CAPSULE, EXTENDED RELEASE 75 mg ORAL ANDA 34 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-4270 TABLET, FILM COATED, EXTENDED RELEASE 15 mg ORAL ANDA 20 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-4271 TABLET, FILM COATED, EXTENDED RELEASE 30 mg ORAL ANDA 20 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-4311 TABLET, FILM COATED, EXTENDED RELEASE 60 mg ORAL ANDA 20 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-4323 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL ANDA 20 sections
Morphine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0228-4347 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL ANDA 20 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0406-5118 TABLET 15 mg ORAL ANDA 34 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0406-5119 TABLET 30 mg ORAL ANDA 34 sections
Morphine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0406-8003 SOLUTION 20 mg ORAL ANDA 35 sections
MORPHINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0406-8315 TABLET, EXTENDED RELEASE 15 mg ORAL ANDA 36 sections