simvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 2445 79902-63-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • simvastatin
  • sinvacor
  • simvastol
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
  • Molecular weight: 418.57
  • Formula: C25H38O5
  • CLOGP: 4.48
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 72.83
  • ALOGS: -4.53
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.37 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 3 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 23, 1991 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 2204.21 9.91 1619 243940 42332 63201131
Myalgia 968.83 9.91 1900 243659 144629 63098834
Drug interaction 831.36 9.91 2349 243210 226782 63016681
Drug ineffective 747.55 9.91 1860 243699 1042905 62200558
Maternal exposure during pregnancy 644.04 9.91 56 245503 220006 63023457
Blood creatine phosphokinase increased 611.83 9.91 669 244890 29761 63213702
Systemic lupus erythematosus 609.10 9.91 54 245505 208864 63034599
Pemphigus 593.01 9.91 28 245531 183698 63059765
Acute kidney injury 575.45 9.91 2276 243283 261139 62982324
Hand deformity 543.05 9.91 16 245543 159441 63084022
Myopathy 504.30 9.91 387 245172 10804 63232659
Glossodynia 500.96 9.91 54 245505 178822 63064641
Off label use 498.32 9.91 1178 244381 673284 62570179
Synovitis 472.12 9.91 78 245481 186840 63056623
Treatment failure 458.56 9.91 104 245455 198939 63044524
Contraindicated product administered 399.17 9.91 171 245388 217477 63025986
Infusion related reaction 377.79 9.91 242 245317 245279 62998184
Myocardial infarction 374.07 9.91 1037 244522 98856 63144607
Drug intolerance 344.75 9.91 412 245147 308249 62935214
Fall 334.15 9.91 2626 242933 389708 62853755
Product use issue 328.89 9.91 225 245334 220295 63023168
Therapeutic product effect decreased 314.51 9.91 178 245381 193009 63050454
Joint swelling 312.94 9.91 490 245069 327176 62916287
Exposure during pregnancy 308.62 9.91 108 245451 155439 63088024
Arthropathy 305.42 9.91 275 245284 234517 63008946
Rheumatoid arthritis 289.54 9.91 333 245226 253486 62989977
Duodenal ulcer perforation 288.87 9.91 11 245548 87198 63156265
Discomfort 287.43 9.91 144 245415 167230 63076233
Hyponatraemia 275.99 9.91 1006 244553 110894 63132569
Alopecia 267.59 9.91 566 244993 336970 62906493
Swelling 266.48 9.91 408 245151 274970 62968493
Coronary artery disease 265.27 9.91 461 245098 31916 63211547
Wound 262.03 9.91 153 245406 163110 63080353
Pericarditis 253.14 9.91 96 245463 131483 63111980
Cerebrovascular accident 239.76 9.91 939 244620 107085 63136378
Helicobacter infection 231.31 9.91 40 245519 92745 63150718
Folliculitis 229.08 9.91 10 245549 70307 63173156
Abdominal discomfort 223.84 9.91 576 244983 320309 62923154
Syncope 217.16 9.91 965 244594 116420 63127043
Muscular weakness 207.90 9.91 981 244578 121372 63122091
Rheumatoid factor positive 202.65 9.91 40 245519 84366 63159097
Immune-mediated myositis 200.97 9.91 100 245459 1243 63242220
Sleep disorder due to general medical condition, insomnia type 186.41 9.91 3 245556 52214 63191249
Lactic acidosis 186.33 9.91 439 245120 37848 63205615
Product prescribing error 185.68 9.91 351 245208 25938 63217525
Nasopharyngitis 185.34 9.91 446 245113 253811 62989652
Hypoglycaemia 180.48 9.91 577 244982 59488 63183975
Transient ischaemic attack 179.53 9.91 429 245130 37324 63206139
Atrial fibrillation 178.70 9.91 908 244651 115728 63127735
Myositis 178.04 9.91 199 245360 9067 63234396
Hypersensitivity 177.85 9.91 561 244998 292124 62951339
Hepatic enzyme increased 176.83 9.91 320 245239 202008 63041455
Dizziness 175.55 9.91 2480 243079 427445 62816018
Condition aggravated 175.23 9.91 880 244679 401337 62842126
Labelled drug-drug interaction medication error 166.13 9.91 231 245328 13168 63230295
Infection 164.63 9.91 405 245154 228768 63014695
International normalised ratio increased 156.24 9.91 464 245095 45961 63197502
Gastrointestinal haemorrhage 155.89 9.91 675 244884 80501 63162962
Renal failure 155.13 9.91 879 244680 116773 63126690
Hyperkalaemia 150.56 9.91 507 245052 53696 63189767
C-reactive protein abnormal 148.69 9.91 7 245552 46089 63197374
Angioedema 147.04 9.91 464 245095 47501 63195962
Muscle injury 144.74 9.91 37 245522 65308 63178155
Product use in unapproved indication 141.93 9.91 300 245259 178780 63064683
Pain 136.56 9.91 2031 243528 738597 62504866
Rash 132.62 9.91 1459 244100 559412 62684051
Irritable bowel syndrome 128.27 9.91 80 245479 82332 63161131
Psoriatic arthropathy 127.70 9.91 100 245459 91420 63152043
Intentional product use issue 125.94 9.91 187 245372 127705 63115758
Asthenia 124.37 9.91 2129 243430 381475 62861988
Stomatitis 119.73 9.91 221 245338 138504 63104959
Product monitoring error 119.22 9.91 115 245444 4401 63239062
Cardiac failure congestive 118.16 9.91 685 244874 91748 63151715
Lower respiratory tract infection 116.66 9.91 208 245351 132099 63111364
Acute myocardial infarction 115.71 9.91 329 245230 31795 63211668
Abortion spontaneous 114.04 9.91 22 245537 47173 63196290
Device expulsion 110.42 9.91 6 245553 34916 63208547
Sinusitis 109.67 9.91 477 245082 226176 63017287
Dehydration 106.64 9.91 1082 244477 172272 63071191
Chest pain 103.78 9.91 1284 244275 214675 63028788
Therapeutic product effect incomplete 102.01 9.91 206 245353 124850 63118613
Blood glucose increased 100.81 9.91 611 244948 83145 63160318
Gastrointestinal disorder 100.52 9.91 224 245335 131015 63112448
Liver function test abnormal 98.96 9.91 409 245150 47772 63195691
Ill-defined disorder 98.90 9.91 102 245457 81653 63161810
Blister 97.45 9.91 224 245335 129590 63113873
Febrile neutropenia 95.86 9.91 196 245363 118253 63125210
Arteriosclerosis coronary artery 93.00 9.91 137 245422 8236 63235227
Amnesia 91.65 9.91 442 245117 55143 63188320
Musculoskeletal stiffness 91.46 9.91 385 245174 184233 63059230
Muscle spasms 89.58 9.91 961 244598 155189 63088274
Haematemesis 86.68 9.91 287 245272 30125 63213338
Hip arthroplasty 86.33 9.91 38 245521 47608 63195855
Pregnancy 85.22 9.91 19 245540 36817 63206646
Oedema peripheral 85.17 9.91 1113 244446 188398 63055065
Fibromyalgia 83.71 9.91 113 245446 80307 63163156
Bradycardia 81.12 9.91 523 245036 72704 63170759
Necrotising myositis 79.01 9.91 40 245519 517 63242946
Diabetes mellitus inadequate control 77.48 9.91 177 245382 14949 63228514
Cerebral haemorrhage 75.44 9.91 276 245283 30453 63213010
Renal impairment 75.15 9.91 592 244967 87763 63155700
Confusional state 74.67 9.91 1307 244252 235073 63008390
Angina pectoris 74.56 9.91 271 245288 29807 63213656
Impaired healing 73.72 9.91 181 245378 102361 63141102
Gait disturbance 73 9.91 1053 244506 182125 63061338
Subarachnoid haemorrhage 71.91 9.91 166 245393 14117 63229346
Haematochezia 71.81 9.91 402 245157 53142 63190321
Nightmare 71.49 9.91 199 245360 18995 63224468
Upper gastrointestinal haemorrhage 70.76 9.91 196 245363 18656 63224807
Pyrexia 69.82 9.91 1341 244218 469137 62774326
Knee arthroplasty 66.27 9.91 67 245492 54139 63189324
Drug abuse 65.72 9.91 112 245447 72406 63171057
Anaemia 63.47 9.91 1534 244025 291896 62951567
Muscle atrophy 62.69 9.91 104 245455 6929 63236534
Completed suicide 62.52 9.91 320 245239 145353 63098110
Lip swelling 62.46 9.91 262 245297 30801 63212662
Circulatory collapse 61.60 9.91 206 245353 21732 63221731
Carotid artery occlusion 61.31 9.91 83 245476 4611 63238852
Cardiospasm 60.88 9.91 54 245505 1853 63241610
Chronic obstructive pulmonary disease 60.64 9.91 433 245126 62253 63181210
Hyperglycaemia 60.63 9.91 321 245238 41546 63201917
Palmoplantar keratoderma 60.46 9.91 55 245504 1952 63241511
Swollen tongue 59.01 9.91 279 245280 34521 63208942
Live birth 57.74 9.91 14 245545 25616 63217847
Hypotension 57.70 9.91 1421 244138 271183 62972280
Melaena 57.11 9.91 251 245308 30114 63213349
Acute coronary syndrome 56.94 9.91 123 245436 10003 63233460
Lethargy 56.59 9.91 391 245168 55616 63187847
Pain in extremity 56.25 9.91 1679 243880 329807 62913656
Cardiovascular disorder 55.89 9.91 134 245425 11678 63231785
Palpitations 54.74 9.91 672 244887 112098 63131365
Pruritus genital 54.45 9.91 59 245500 2595 63240868
Sinus bradycardia 54.33 9.91 151 245408 14400 63229063
Presyncope 53.27 9.91 231 245328 27554 63215909
Malignant neoplasm progression 52.92 9.91 153 245406 81968 63161495
Toxicity to various agents 52.85 9.91 657 244902 246593 62996870
Arthralgia 52.54 9.91 1742 243817 567968 62675495
Sleep terror 52.24 9.91 58 245501 2622 63240841
Therapy non-responder 52.21 9.91 137 245422 75764 63167699
Urosepsis 52.06 9.91 174 245385 18350 63225113
Blood creatinine increased 51.91 9.91 544 245015 87300 63156163
Haemorrhage intracranial 51.84 9.91 141 245418 13278 63230185
Angina unstable 51.67 9.91 96 245463 6999 63236464
Dyspnoea 51.52 9.91 3085 242474 658228 62585235
Hypokalaemia 50.57 9.91 619 244940 103185 63140278
Blood pressure inadequately controlled 50.38 9.91 78 245481 4900 63238563
Coronary artery occlusion 50.13 9.91 103 245456 8088 63235375
Chronic kidney disease 49.51 9.91 323 245236 45075 63198388
Polymyositis 49.37 9.91 47 245512 1769 63241694
Lower gastrointestinal haemorrhage 49.22 9.91 100 245459 7790 63235673
Coronary artery stenosis 48.95 9.91 75 245484 4669 63238794
Unresponsive to stimuli 48.78 9.91 259 245300 33557 63209906
Weight increased 48.51 9.91 713 244846 260079 62983384
Mitral valve incompetence 48.10 9.91 176 245383 19418 63224045
Bone erosion 47.92 9.91 6 245553 17711 63225752
Hypertensive crisis 47.87 9.91 149 245410 15137 63228326
Carotid arteriosclerosis 47.11 9.91 37 245522 1069 63242394
Foetal exposure during pregnancy 47.05 9.91 33 245526 31929 63211534
Pancreatitis acute 46.94 9.91 219 245340 26947 63216516
Muscle twitching 46.89 9.91 175 245384 19493 63223970
Atrial tachycardia 46.55 9.91 69 245490 4171 63239292
Premature delivery 46.28 9.91 30 245529 30251 63213212
Disturbance in attention 46.18 9.91 279 245280 37910 63205553
Cutaneous T-cell dyscrasia 45.49 9.91 15 245544 55 63243408
Subdural haematoma 44.25 9.91 139 245420 14189 63229274
Left ventricular hypertrophy 43.94 9.91 76 245483 5239 63238224
Liver injury 43.35 9.91 107 245452 60413 63183050
Ischaemic stroke 42.99 9.91 160 245399 17797 63225666
Drug resistance 42.00 9.91 18 245541 22915 63220548
Loss of consciousness 41.97 9.91 666 244893 117455 63126008
Sedation complication 41.82 9.91 3 245556 13819 63229644
Hyperhidrosis 41.77 9.91 617 244942 107219 63136244
Femoral neck fracture 41.75 9.91 98 245461 8425 63235038
Tendon rupture 41.74 9.91 96 245463 8143 63235320
Sinus node dysfunction 41.38 9.91 69 245490 4616 63238847
Muscle necrosis 41.31 9.91 28 245531 640 63242823
Myelosuppression 41.24 9.91 20 245539 23683 63219780
Caesarean section 41.02 9.91 8 245551 17024 63226439
Prescribed overdose 40.85 9.91 43 245516 34110 63209353
High density lipoprotein decreased 40.65 9.91 46 245513 2124 63241339
Decorticate posture 40.52 9.91 21 245538 286 63243177
Blood glucose decreased 40.02 9.91 174 245385 20778 63222685
Peripheral swelling 39.97 9.91 756 244803 265186 62978277
Pancreatitis 39.69 9.91 325 245234 48730 63194733
Urinary tract infection 38.66 9.91 1317 244242 263367 62980096
Tachyarrhythmia 38.59 9.91 65 245494 4385 63239078
Immunisation 38.52 9.91 34 245525 1159 63242304
Peripheral vascular disorder 38.25 9.91 77 245482 5958 63237505
Myocardial depression 38.20 9.91 24 245535 480 63242983
Collagen disorder 37.71 9.91 18 245541 203 63243260
Myoglobin blood increased 37.51 9.91 36 245523 1369 63242094
Ventricular tachycardia 36.70 9.91 164 245395 19815 63223648
Labile hypertension 36.48 9.91 23 245536 463 63243000
Head injury 36.27 9.91 205 245354 27191 63216272
Blood loss anaemia 36.20 9.91 96 245463 8905 63234558
Anosmia 35.94 9.91 81 245478 6779 63236684
Illness 35.71 9.91 86 245473 48973 63194490
Diabetic ketoacidosis 35.20 9.91 165 245394 20340 63223123
Tension headache 35.08 9.91 68 245491 5118 63238345
Migraine 34.84 9.91 245 245314 103101 63140362
Haematuria 34.61 9.91 212 245347 28945 63214518
Intermittent claudication 34.48 9.91 39 245520 1800 63241663
Disease progression 34.43 9.91 306 245253 122452 63121011
Chromaturia 34.39 9.91 142 245417 16575 63226888
Ischaemic cardiomyopathy 34.20 9.91 45 245514 2432 63241031
Hypothermia 34.19 9.91 123 245436 13458 63230005
COVID-19 33.93 9.91 277 245282 112826 63130637
Femoral hernia incarcerated 33.40 9.91 27 245532 814 63242649
Peripheral arterial occlusive disease 33.34 9.91 59 245500 4142 63239321
Drug ineffective for unapproved indication 33.32 9.91 50 245509 34013 63209450
Blindness 33.23 9.91 169 245390 21530 63221933
Diverticulum 33.13 9.91 112 245447 11879 63231584
Gouty tophus 33.03 9.91 17 245542 228 63243235
Haematoma 32.79 9.91 239 245320 34581 63208882
Injection site pain 32.39 9.91 333 245226 129467 63113996
Aortic arteriosclerosis 32.18 9.91 73 245486 6136 63237327
Arrhythmia 32.11 9.91 255 245304 37885 63205578
Hemiparesis 32.01 9.91 176 245383 23106 63220357
Coronary artery thrombosis 31.96 9.91 30 245529 1109 63242354
Electrocardiogram QT prolonged 31.63 9.91 361 245198 59169 63184294
Malaise 31.63 9.91 1937 243622 414017 62829446
Torsade de pointes 31.17 9.91 118 245441 13233 63230230
Hospitalisation 30.52 9.91 198 245361 84883 63158580
Deep vein thrombosis postoperative 30.39 9.91 4 245555 11365 63232098
Dysarthria 29.86 9.91 274 245285 42437 63201026
Premature labour 29.84 9.91 6 245553 12498 63230965
Muscle disorder 29.84 9.91 62 245497 4907 63238556
Myoglobinuria 29.80 9.91 17 245542 283 63243180
Postprandial hypoglycaemia 29.72 9.91 11 245548 61 63243402
Haemodialysis 29.68 9.91 89 245470 8858 63234605
Injection site reaction 29.59 9.91 121 245438 58403 63185060
Swelling face 29.39 9.91 375 245184 63100 63180363
Cytomegalovirus infection 29.08 9.91 23 245536 20929 63222534
Disorientation 29.07 9.91 256 245303 39196 63204267
Neutropenia 28.96 9.91 489 245070 174516 63068947
Facial paresis 28.89 9.91 50 245509 3448 63240015
Crystal nephropathy 28.88 9.91 26 245533 910 63242553
Device difficult to use 28.80 9.91 7 245552 12789 63230674
Arteriosclerosis 28.68 9.91 95 245464 9971 63233492
Fatigue 28.45 9.91 3005 242554 885023 62358440
Adverse drug reaction 28.35 9.91 186 245373 79528 63163935
Colitis microscopic 28.29 9.91 90 245469 9249 63234214
Pancreatitis necrotising 28.25 9.91 34 245525 1678 63241785
Grip strength decreased 27.87 9.91 27 245532 22260 63221203
Autoimmune hepatitis 27.62 9.91 84 245475 8426 63235037
Glomerular filtration rate decreased 27.51 9.91 114 245445 13327 63230136
Blood cholesterol increased 27.43 9.91 232 245327 93800 63149663
Glycogen storage disease type V 27.35 9.91 6 245553 0 63243463
Body temperature decreased 27.33 9.91 23 245536 20296 63223167
Varicose vein 27.32 9.91 60 245499 4935 63238528
Hallucination, visual 27.28 9.91 147 245412 19151 63224312
Diplopia 27.21 9.91 171 245388 23557 63219906
Cerebrospinal fluid retention 27.10 9.91 11 245548 81 63243382
Inappropriate schedule of product administration 27.06 9.91 264 245295 103701 63139762
Pancreatic steatosis 27.06 9.91 26 245533 990 63242473
Hip fracture 27.01 9.91 201 245358 29273 63214190
Nodular rash 26.99 9.91 14 245545 191 63243272
Type 2 diabetes mellitus 26.99 9.91 141 245418 63727 63179736
Breast cancer stage III 26.95 9.91 4 245555 10382 63233081
Angioplasty 26.92 9.91 30 245529 1362 63242101
Faeces discoloured 26.85 9.91 142 245417 18367 63225096
Glycosylated haemoglobin increased 26.84 9.91 107 245452 12291 63231172
Foetal death 26.77 9.91 5 245554 10975 63232488
Abnormal loss of weight 26.72 9.91 65 245494 5717 63237746
Quadriparesis 26.69 9.91 36 245523 1993 63241470
Haemorrhagic stroke 26.65 9.91 65 245494 5727 63237736
Visual impairment 26.63 9.91 467 245092 83979 63159484
Facet joint syndrome 26.63 9.91 7 245552 12131 63231332
Musculoskeletal toxicity 26.50 9.91 10 245549 59 63243404
Wheezing 26.49 9.91 239 245320 95356 63148107
Neutrophil count decreased 26.45 9.91 120 245439 56286 63187177
Post viral fatigue syndrome 26.33 9.91 16 245543 301 63243162
Cold sweat 26.10 9.91 104 245455 11943 63231520
Blood urea increased 25.96 9.91 183 245376 26196 63217267
Oesophagitis 25.93 9.91 121 245438 14887 63228576
Liver function test increased 25.93 9.91 55 245504 32756 63210707
Carotid artery stenosis 25.93 9.91 60 245499 5110 63238353
Joint range of motion decreased 25.93 9.91 54 245505 32374 63211089
Haemarthrosis 25.87 9.91 45 245514 3116 63240347
Wound dehiscence 25.81 9.91 58 245501 4845 63238618
Low density lipoprotein increased 25.77 9.91 68 245491 6289 63237174
Ear pain 25.75 9.91 64 245495 36054 63207409
Blood sodium decreased 25.50 9.91 171 245388 24081 63219382
Myocardial ischaemia 25.49 9.91 108 245451 12751 63230712
Myopathy toxic 25.36 9.91 19 245540 511 63242952
Tremor 25.20 9.91 680 244879 131559 63111904
Visual acuity reduced 24.84 9.91 157 245402 21669 63221794
Cerebral infarction 24.84 9.91 168 245391 23725 63219738
Oedema mouth 24.69 9.91 38 245521 2375 63241088
Vascular stent stenosis 24.64 9.91 19 245540 534 63242929
Lymphatic fistula 24.58 9.91 22 245537 764 63242699
Blood pressure fluctuation 24.54 9.91 94 245465 46223 63197240
Vision blurred 24.39 9.91 495 245064 91429 63152034
Facial pain 24.37 9.91 93 245466 10468 63232995
Hyperlipidaemia 24.31 9.91 144 245415 19427 63224036
Asthma 24.29 9.91 347 245212 127214 63116249
Adjustment disorder with depressed mood 24.14 9.91 5 245554 10199 63233264
Urinary retention 24.10 9.91 200 245359 30101 63213362
Diabetic hyperosmolar coma 24.06 9.91 16 245543 354 63243109
Retinal artery thrombosis 24.04 9.91 10 245549 79 63243384
Night sweats 24.01 9.91 102 245457 48712 63194751
Memory impairment 24.00 9.91 550 245009 103708 63139755
Hepatic cyst 23.88 9.91 58 245501 5096 63238367
Electrocardiogram abnormal 23.85 9.91 84 245475 9095 63234368
Extrasystoles 23.84 9.91 58 245501 5102 63238361
Therapy partial responder 23.66 9.91 6 245553 10652 63232811
Exercise tolerance decreased 23.51 9.91 60 245499 5437 63238026
Parkinsonism 23.33 9.91 91 245468 10348 63233115
Erythema dyschromicum perstans 23.32 9.91 9 245550 57 63243406
Suicide attempt 23.28 9.91 139 245420 60779 63182684
Bundle branch block left 23.21 9.91 70 245489 6989 63236474
Balance disorder 23.19 9.91 457 245102 83965 63159498
International normalised ratio abnormal 23.18 9.91 44 245515 3260 63240203
Product used for unknown indication 23.10 9.91 18 245541 514 63242949
Brucellosis 23.06 9.91 9 245550 59 63243404
Ventricular extrasystoles 23.04 9.91 98 245461 11589 63231874
Acetonaemia 22.89 9.91 11 245548 126 63243337
Apolipoprotein A-I decreased 22.80 9.91 7 245552 19 63243444
Speech disorder 22.77 9.91 249 245310 40380 63203083
Electrolyte imbalance 22.60 9.91 144 245415 19932 63223531
Ageusia 22.50 9.91 109 245450 13619 63229844
Lichenoid keratosis 22.49 9.91 31 245528 1752 63241711
Tricuspid valve incompetence 22.48 9.91 114 245445 14507 63228956
Drug hypersensitivity 22.34 9.91 978 244581 309709 62933754
Lung disorder 22.27 9.91 145 245414 62116 63181347
Inflammation 22.23 9.91 207 245352 82066 63161397
Transplant rejection 22.21 9.91 7 245552 10773 63232690
Dyslipidaemia 22.17 9.91 71 245488 7322 63236141
Poor venous access 22.12 9.91 15 245544 14770 63228693
Disability 22.05 9.91 23 245536 18324 63225139
Haemoglobin decreased 21.74 9.91 726 244833 144759 63098704
Bursitis 21.74 9.91 72 245487 36969 63206494
Incorrect route of product administration 21.71 9.91 46 245513 27406 63216057
Tinnitus 21.68 9.91 222 245337 35406 63208057
Sleep disorder due to a general medical condition 21.64 9.91 10 245549 12178 63231285
Atrioventricular block 21.64 9.91 72 245487 7575 63235888
Toxic shock syndrome 21.40 9.91 21 245538 821 63242642
Alanine aminotransferase increased 21.33 9.91 539 245020 103231 63140232
Device issue 21.29 9.91 37 245522 23744 63219719
Autoimmune disorder 21.25 9.91 21 245538 17156 63226307
Ankylosing spondylitis 21.22 9.91 7 245552 10467 63232996
Neuropathy, ataxia, retinitis pigmentosa syndrome 21.09 9.91 8 245551 48 63243415
Serotonin syndrome 21.07 9.91 186 245373 28496 63214967
Seroma 21.02 9.91 33 245526 2098 63241365
Loss of personal independence in daily activities 20.95 9.91 258 245301 97032 63146431
Blood glucose fluctuation 20.68 9.91 51 245508 4525 63238938
Hypovolaemia 20.66 9.91 89 245470 10584 63232879
Therapeutic response decreased 20.66 9.91 146 245413 61379 63182084
Diverticulum intestinal 20.62 9.91 65 245494 6648 63236815
Hallucination 20.57 9.91 312 245247 54505 63188958
Heavy menstrual bleeding 20.56 9.91 23 245536 17750 63225713
Duodenal ulcer repair 20.43 9.91 8 245551 53 63243410
Injection site bruising 20.35 9.91 88 245471 41822 63201641
Mobility decreased 20.21 9.91 338 245221 120821 63122642
Accidental exposure to product 19.98 9.91 48 245511 27357 63216106
Mitochondrial myopathy 19.97 9.91 9 245550 88 63243375
Feeling abnormal 19.81 9.91 731 244828 147661 63095802
Aphasia 19.78 9.91 205 245354 32795 63210668
Helicobacter gastritis 19.76 9.91 28 245531 1624 63241839
Contraindicated product prescribed 19.75 9.91 25 245534 1300 63242163
Premature baby 19.74 9.91 31 245528 20704 63222759
Injection site erythema 19.68 9.91 216 245343 82958 63160505
Blood triglycerides increased 19.64 9.91 98 245461 12390 63231073
Mucosal inflammation 19.60 9.91 104 245455 46824 63196639
Cerebellar ischaemia 19.58 9.91 8 245551 60 63243403
Illness anxiety disorder 19.57 9.91 10 245549 132 63243331
Maternal exposure before pregnancy 19.56 9.91 3 245556 7600 63235863
Rectal haemorrhage 19.55 9.91 282 245277 48748 63194715
Endocrine ophthalmopathy 19.46 9.91 18 245541 653 63242810
Tenosynovitis 19.33 9.91 15 245544 13780 63229683
Product dose omission issue 19.32 9.91 726 244833 233587 63009876
Therapeutic response shortened 19.25 9.91 11 245548 11877 63231586
General physical health deterioration 19.22 9.91 958 244601 200444 63043019
Arterial stenosis 19.20 9.91 17 245542 582 63242881
Faeces pale 18.93 9.91 28 245531 1689 63241774
Hypomagnesaemia 18.91 9.91 182 245377 28555 63214908
Conjunctival discolouration 18.89 9.91 9 245550 101 63243362
Amaurosis fugax 18.87 9.91 15 245544 441 63243022
Degenerative aortic valve disease 18.74 9.91 10 245549 145 63243318
Listless 18.74 9.91 37 245522 2823 63240640
Urticaria 18.69 9.91 493 245066 165309 63078154
Blood potassium increased 18.59 9.91 128 245431 18181 63225282
Renal injury 18.49 9.91 79 245480 9360 63234103
Aortic valve stenosis 18.47 9.91 40 245519 3259 63240204
Abnormal dreams 18.33 9.91 85 245474 10431 63233032
Fear 18.31 9.91 114 245445 15652 63227811
Cytokine release syndrome 18.29 9.91 17 245542 14297 63229166
Low turnover osteopathy 18.23 9.91 46 245513 4139 63239324
Dysphagia 18.17 9.91 460 245099 88125 63155338
Rhinorrhoea 18.14 9.91 164 245395 65413 63178050
Wound infection pseudomonas 18.14 9.91 24 245535 1304 63242159
Diabetes mellitus 18.08 9.91 310 245249 55500 63187963
Fear of injection 18.04 9.91 3 245556 7161 63236302
Systemic infection 18.03 9.91 49 245510 4611 63238852
Cardiac failure 18.02 9.91 462 245097 88680 63154783
Carotid bruit 17.98 9.91 18 245541 721 63242742
Intentional overdose 17.77 9.91 192 245367 73960 63169503
Gastric ulcer 17.72 9.91 156 245403 23881 63219582
Apraxia 17.69 9.91 28 245531 1793 63241670
Wound infection 17.67 9.91 35 245524 21375 63222088
Anal incontinence 17.58 9.91 101 245458 13475 63229988
Arthritis 17.55 9.91 329 245230 115592 63127871
Arterial haemorrhage 17.51 9.91 27 245532 1690 63241773
Disease recurrence 17.49 9.91 53 245506 27977 63215486
Pancreatic carcinoma 17.46 9.91 67 245492 7561 63235902
Amyotrophic lateral sclerosis 17.42 9.91 22 245537 1141 63242322
Pain of skin 17.39 9.91 90 245469 11544 63231919
Femur fracture 17.39 9.91 242 245317 41514 63201949
Neoplasm progression 17.38 9.91 77 245482 36351 63207112
Sedation 17.35 9.91 84 245475 38725 63204738
Asphyxia 17.31 9.91 58 245501 6123 63237340
Poisoning deliberate 17.30 9.91 11 245548 11207 63232256
Vulvovaginal burning sensation 17.23 9.91 30 245529 2079 63241384
Hypoglycaemic unconsciousness 17.23 9.91 18 245541 759 63242704
X-ray abnormal 17.19 9.91 5 245554 8105 63235358
Ventricular hypokinesia 17.15 9.91 48 245511 4596 63238867
Labelled drug-food interaction medication error 17.14 9.91 10 245549 174 63243289
Gastritis 17.10 9.91 220 245339 37083 63206380
International normalised ratio decreased 17.09 9.91 47 245512 4454 63239009
Ketoacidosis 16.91 9.91 46 245513 4332 63239131
Hand-eye coordination impaired 16.88 9.91 6 245553 29 63243434
Spontaneous haematoma 16.85 9.91 19 245540 874 63242589
Myoclonus 16.75 9.91 112 245447 15756 63227707
Jaundice 16.73 9.91 180 245379 29071 63214392
Ubiquinone decreased 16.72 9.91 5 245554 12 63243451
Sodium retention 16.72 9.91 9 245550 133 63243330
Groin pain 16.71 9.91 81 245478 10122 63233341
Anuria 16.67 9.91 94 245465 12457 63231006
Coronary arterial stent insertion 16.64 9.91 35 245524 2794 63240669
Loose tooth 16.60 9.91 39 245520 3355 63240108
Pharyngitis 16.56 9.91 33 245526 20110 63223353
Pancreatitis relapsing 16.56 9.91 19 245540 891 63242572
Febrile bone marrow aplasia 16.50 9.91 4 245555 7321 63236142
Linear IgA disease 16.49 9.91 24 245535 1427 63242036
Tachycardia 16.49 9.91 585 244974 117571 63125892
Electrocardiogram PR prolongation 16.46 9.91 17 245542 707 63242756
Retinal coloboma 16.40 9.91 6 245553 32 63243431
Autoimmune myositis 16.31 9.91 9 245550 140 63243323
Erythromelalgia 16.31 9.91 9 245550 140 63243323
Sinus arrest 16.28 9.91 28 245531 1921 63241542
Haematotoxicity 16.17 9.91 8 245551 9368 63234095
Sprue-like enteropathy 16.09 9.91 17 245542 726 63242737
Pulmonary oedema 16.08 9.91 300 245259 54573 63188890
Metastases to bone 15.98 9.91 36 245523 20983 63222480
Peripheral venous disease 15.84 9.91 22 245537 15455 63228008
Intraventricular haemorrhage 15.83 9.91 29 245530 2091 63241372
Lymph node palpable 15.83 9.91 8 245551 103 63243360
Transient global amnesia 15.82 9.91 16 245543 649 63242814
Gait inability 15.68 9.91 290 245269 52669 63190794
Brain contusion 15.64 9.91 15 245544 570 63242893
Cognitive disorder 15.62 9.91 303 245256 55512 63187951
Cerebral amyloid angiopathy 15.61 9.91 9 245550 153 63243310
Subclavian vein thrombosis 15.59 9.91 27 245532 1863 63241600
White blood cell count decreased 15.57 9.91 414 245145 138690 63104773
Cerebellar infarction 15.56 9.91 28 245531 1991 63241472
Hypophagia 15.47 9.91 187 245372 31072 63212391
Vasculitis 15.46 9.91 122 245437 18087 63225376
Language disorder 15.45 9.91 29 245530 2131 63241332
Pathogen resistance 15.42 9.91 3 245556 6395 63237068
Cerebral ischaemia 15.32 9.91 59 245500 6669 63236794
Lacunar infarction 15.29 9.91 37 245522 3243 63240220
Multiple injuries 15.24 9.91 26 245533 1772 63241691
Iris coloboma 15.16 9.91 6 245553 41 63243422
Muscle strength abnormal 15.14 9.91 7 245552 73 63243390
Cerebral artery occlusion 15.14 9.91 18 245541 877 63242586
Blood creatine phosphokinase MB increased 15.13 9.91 21 245538 1195 63242268
Body height decreased 15.09 9.91 78 245481 10000 63233463
Leukocyturia 15.08 9.91 23 245536 1426 63242037
Parakeratosis 15.07 9.91 11 245548 284 63243179
Device dislocation 15.06 9.91 50 245509 25655 63217808
Tumour lysis syndrome 15.02 9.91 8 245551 8982 63234481
Chronic sinusitis 15 9.91 93 245466 12750 63230713
Blood urine 14.98 9.91 13 245546 433 63243030
Cardiac disorder 14.95 9.91 278 245281 50538 63192925
Brain stem infarction 14.90 9.91 17 245542 792 63242671
Osteonecrosis of external auditory canal 14.81 9.91 8 245551 119 63243344
Diabetic neuropathy 14.66 9.91 41 245518 3923 63239540
Fracture blisters 14.66 9.91 7 245552 79 63243384
Movement disorder 14.66 9.91 138 245421 21523 63221940
Supraventricular extrasystoles 14.62 9.91 45 245514 4544 63238919
Cardiogenic shock 14.61 9.91 119 245440 17813 63225650
Acne 14.56 9.91 44 245515 23249 63220214
Blood creatine phosphokinase abnormal 14.55 9.91 10 245549 234 63243229
Bone marrow failure 14.53 9.91 61 245498 29229 63214234
Mitral valve sclerosis 14.52 9.91 8 245551 124 63243339
Temperature regulation disorder 14.52 9.91 3 245556 6129 63237334
Diverticular perforation 14.47 9.91 38 245521 3504 63239959
Ischaemia 14.47 9.91 46 245513 4726 63238737
Femoral artery embolism 14.46 9.91 6 245553 47 63243416
Adverse reaction 14.41 9.91 11 245548 10192 63233271
Wrist fracture 14.40 9.91 96 245463 13491 63229972
Genital swelling 14.30 9.91 8 245551 128 63243335
Breast cancer stage II 14.26 9.91 8 245551 8728 63234735
Dysgeusia 14.25 9.91 257 245302 46453 63197010
Adverse event 14.23 9.91 180 245379 67379 63176084
Dermatitis exfoliative 14.22 9.91 50 245509 5409 63238054
Ear infection 14.18 9.91 88 245471 38125 63205338
Mitral valve stenosis 14.16 9.91 20 245539 1157 63242306
Nasal ulcer 14.13 9.91 29 245530 2275 63241188
Bundle branch block right 14.09 9.91 47 245512 4951 63238512
Drug dependence 14.09 9.91 48 245511 24435 63219028
Product substitution issue 14.04 9.91 108 245451 15888 63227575
Low birth weight baby 14.04 9.91 5 245554 7124 63236339
Poliomyelitis 13.94 9.91 6 245553 52 63243411
Urinary incontinence 13.92 9.91 187 245372 31827 63211636
Lip dry 13.91 9.91 24 245535 15446 63228017
Product dose omission in error 13.90 9.91 6 245553 7606 63235857
Left ventricular failure 13.89 9.91 51 245508 5636 63237827
Motor neurone disease 13.88 9.91 8 245551 136 63243327
Self esteem decreased 13.87 9.91 15 245544 658 63242805
Rash papular 13.78 9.91 106 245453 15596 63227867
Bladder trabeculation 13.75 9.91 6 245553 54 63243409
Foetal growth restriction 13.72 9.91 6 245553 7547 63235916
Pneumocystis jirovecii pneumonia 13.66 9.91 28 245531 16886 63226577
Orbital swelling 13.65 9.91 6 245553 55 63243408
Body temperature increased 13.62 9.91 86 245473 37106 63206357
Amenorrhoea 13.61 9.91 11 245548 9903 63233560
Injection site swelling 13.59 9.91 118 245441 47454 63196009
Coronary artery bypass 13.58 9.91 29 245530 2340 63241123
Ataxia 13.57 9.91 103 245456 15092 63228371
Infusion site pain 13.56 9.91 28 245531 16841 63226622
Diabetic metabolic decompensation 13.55 9.91 24 245535 1686 63241777
Uterine perforation 13.51 9.91 5 245554 6958 63236505
Cerebellar ataxia 13.41 9.91 17 245542 885 63242578
Influenza 13.40 9.91 319 245240 108403 63135060
Rhinalgia 13.39 9.91 23 245536 1576 63241887
C-reactive protein increased 13.36 9.91 272 245287 94435 63149028
Inappropriate antidiuretic hormone secretion 13.35 9.91 104 245455 15358 63228105
Oedema 13.29 9.91 282 245277 97340 63146123
Device use error 13.27 9.91 3 245556 5758 63237705
Coma scale abnormal 13.25 9.91 47 245512 5106 63238357
Aortic valve incompetence 13.22 9.91 52 245507 5936 63237527
Vulvar basal cell carcinoma 13.18 9.91 5 245554 30 63243433
Vertigo 13.18 9.91 314 245245 59573 63183890
Diarrhoea 13.12 9.91 3039 242520 712327 62531136
Fracture displacement 13.10 9.91 20 245539 1241 63242222
Biopsy muscle abnormal 13.04 9.91 5 245554 31 63243432
Muscle spasticity 13.04 9.91 42 245517 21752 63221711
Epistaxis 13.01 9.91 371 245188 72354 63171109
Joint destruction 12.99 9.91 4 245555 6248 63237215
Lower limb fracture 12.93 9.91 49 245510 24172 63219291
Antineutrophil cytoplasmic antibody positive 12.92 9.91 14 245545 616 63242847
Blood pressure systolic increased 12.91 9.91 119 245440 47278 63196185
Stress fracture 12.89 9.91 63 245496 7900 63235563
Red cell distribution width increased 12.87 9.91 13 245546 10511 63232952
Nasal dryness 12.84 9.91 43 245516 4538 63238925
Eructation 12.83 9.91 65 245494 8268 63235195
Vomiting 12.80 9.91 2403 243156 557214 62686249
Macroangiopathy 12.80 9.91 7 245552 107 63243356
Periorbital inflammation 12.78 9.91 6 245553 65 63243398
Respiratory tract haemorrhage 12.77 9.91 12 245547 444 63243019
Hyperthermia 12.77 9.91 10 245549 9146 63234317
Blood pressure systolic abnormal 12.75 9.91 20 245539 13366 63230097
Orthopnoea 12.73 9.91 53 245506 6208 63237255
Exposure to toxic agent 12.69 9.91 3 245556 5584 63237879
Gingival hypertrophy 12.66 9.91 23 245536 1648 63241815
Injury 12.65 9.91 203 245356 73044 63170419
Respiratory disorder 12.51 9.91 94 245465 38988 63204475
Deep vein thrombosis 12.47 9.91 418 245141 83382 63160081
Tuberculosis 12.44 9.91 15 245544 11196 63232267
Haemorrhagic erosive gastritis 12.40 9.91 12 245547 461 63243002
Metabolic acidosis 12.38 9.91 244 245315 44825 63198638
Ovarian cyst 12.37 9.91 27 245532 15918 63227545
Pulmonary toxicity 12.36 9.91 11 245548 9444 63234019
Potentiating drug interaction 12.31 9.91 41 245518 4315 63239148
Cardiomegaly 12.31 9.91 113 245446 17501 63225962
Nasal polyps 12.30 9.91 4 245555 6035 63237428
Eyelid bleeding 12.30 9.91 5 245554 37 63243426
Facial nerve disorder 12.29 9.91 13 245546 556 63242907
Nervousness 12.28 9.91 178 245381 30801 63212662
Long QT syndrome 12.21 9.91 34 245525 3245 63240218
Laryngitis 12.14 9.91 30 245529 16937 63226526
Immunodeficiency 12.14 9.91 39 245520 20215 63223248
Exfoliative rash 12.10 9.91 31 245528 2816 63240647
Menstruation irregular 12.05 9.91 6 245553 6998 63236465
Nodal rhythm 11.97 9.91 23 245536 1720 63241743
Hypoglycaemic coma 11.96 9.91 29 245530 2546 63240917
Blood alkaline phosphatase increased 11.93 9.91 233 245326 42734 63200729
Breath sounds abnormal 11.91 9.91 78 245481 10895 63232568
Radius fracture 11.91 9.91 36 245523 3599 63239864
Dermatitis atopic 11.90 9.91 12 245547 9712 63233751
Death 11.88 9.91 1267 244292 373114 62870349
Obsessive thoughts 11.88 9.91 13 245546 578 63242885
Muscle rupture 11.87 9.91 28 245531 2415 63241048
Normetanephrine urine increased 11.86 9.91 4 245555 16 63243447
Myoglobin urine 11.86 9.91 4 245555 16 63243447
Spasmodic dysphonia 11.82 9.91 6 245553 78 63243385
Orthostatic hypotension 11.76 9.91 201 245358 35959 63207504
Tendon sheath incision 11.75 9.91 6 245553 79 63243384
Spontaneous haemorrhage 11.74 9.91 13 245546 586 63242877
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.74 9.91 31 245528 2868 63240595
Pancreatic carcinoma metastatic 11.73 9.91 26 245533 2152 63241311
Breast cancer stage I 11.70 9.91 6 245553 6883 63236580
Hypoaesthesia 11.69 9.91 532 245027 167861 63075602
Retinal haemorrhage 11.67 9.91 44 245515 4925 63238538
Respiratory tract congestion 11.65 9.91 33 245526 17799 63225664
Peripheral artery stenosis 11.58 9.91 13 245546 595 63242868
Genital haemorrhage 11.57 9.91 7 245552 7325 63236138
Abscess jaw 11.53 9.91 20 245539 1382 63242081
Peroneal nerve palsy 11.51 9.91 43 245516 4792 63238671
Hiatus hernia 11.49 9.91 131 245428 21463 63222000
Weight decreased 11.37 9.91 1230 244329 275568 62967895
Breast atrophy 11.37 9.91 6 245553 85 63243378
Enterococcal sepsis 11.36 9.91 20 245539 1398 63242065
Peripheral embolism 11.34 9.91 19 245540 1276 63242187
Ocular myasthenia 11.32 9.91 7 245552 136 63243327
Skin pressure mark 11.31 9.91 4 245555 19 63243444
Perseveration 11.28 9.91 9 245550 266 63243197
Oxalosis 11.27 9.91 5 245554 47 63243416
Osteoporosis 11.26 9.91 155 245404 57183 63186280
Paresis 11.22 9.91 28 245531 2502 63240961
Mouth swelling 11.15 9.91 42 245517 4698 63238765
Pharyngeal oedema 11.15 9.91 91 245468 13630 63229833
Gastric ulcer haemorrhage 11.14 9.91 43 245516 4865 63238598
Injection site pruritus 11.14 9.91 116 245443 45000 63198463
Pemphigoid 11.11 9.91 57 245502 7287 63236176
Cardiac flutter 11.09 9.91 38 245521 4058 63239405
Adrenal insufficiency 11.09 9.91 34 245525 17881 63225582
Meibomianitis 11.09 9.91 5 245554 49 63243414
Eyelid disorder 11.02 9.91 23 245536 1826 63241637
Coronavirus test positive 11.01 9.91 14 245545 731 63242732
Polymyalgia rheumatica 11.00 9.91 36 245523 3755 63239708
Tessellated fundus 11.00 9.91 5 245554 50 63243413
Degenerative mitral valve disease 10.99 9.91 4 245555 21 63243442
Fracture 10.96 9.91 120 245439 19464 63223999
Colitis ischaemic 10.96 9.91 75 245484 10633 63232830
Eye swelling 10.94 9.91 141 245418 23777 63219686
Cushingoid 10.94 9.91 10 245549 8475 63234988
Aspartate aminotransferase increased 10.92 9.91 440 245119 89837 63153626
Coombs negative haemolytic anaemia 10.91 9.91 8 245551 208 63243255
Cerebral ventricular rupture 10.91 9.91 8 245551 208 63243255
Ophthalmoplegia 10.90 9.91 20 245539 1444 63242019
Food allergy 10.89 9.91 17 245542 11384 63232079
Pulmonary hypertension 10.89 9.91 203 245356 36920 63206543
Cerebrovascular disorder 10.85 9.91 29 245530 2703 63240760
Intestinal angioedema 10.79 9.91 13 245546 642 63242821
Occult blood positive 10.78 9.91 35 245524 3635 63239828
Portal fibrosis 10.78 9.91 9 245550 284 63243179
Hypernatraemia 10.78 9.91 58 245501 7551 63235912
Large intestine polyp 10.77 9.91 61 245498 8096 63235367
Electrocardiogram T wave abnormal 10.77 9.91 27 245532 2420 63241043
Nausea 10.74 9.91 3573 241986 850898 62392565
Hypertensive heart disease 10.73 9.91 27 245532 2425 63241038
Androgenetic alopecia 10.72 9.91 7 245552 150 63243313
Reversible ischaemic neurological deficit 10.69 9.91 4 245555 23 63243440
Bacteraemia 10.68 9.91 33 245526 17315 63226148
Electrocardiogram T wave peaked 10.68 9.91 8 245551 215 63243248
Dialysis 10.65 9.91 73 245486 10354 63233109
Forced expiratory volume decreased 10.64 9.91 3 245556 4965 63238498
Oxygen saturation decreased 10.62 9.91 261 245298 88324 63155139
Drug level decreased 10.61 9.91 9 245550 7910 63235553
Aortic stenosis 10.61 9.91 43 245516 4977 63238486
Monoparesis 10.60 9.91 21 245538 1606 63241857
Cerebral arteriosclerosis 10.57 9.91 9 245550 292 63243171
Medication error 10.57 9.91 271 245288 52013 63191450
Peak expiratory flow rate abnormal 10.56 9.91 6 245553 99 63243364
Sickle cell anaemia with crisis 10.54 9.91 5 245554 5998 63237465
Microphthalmos 10.52 9.91 7 245552 155 63243308
Pancreatitis chronic 10.51 9.91 27 245532 2457 63241006
Peripheral ischaemia 10.48 9.91 42 245517 4836 63238627
Gingivitis 10.46 9.91 62 245497 8367 63235096
Hepatitis toxic 10.45 9.91 32 245527 3221 63240242
Bronchiectasis 10.45 9.91 30 245529 16112 63227351
Therapy interrupted 10.42 9.91 78 245481 32377 63211086
Blood glucose abnormal 10.41 9.91 59 245500 7833 63235630
Bladder cyst 10.40 9.91 3 245556 6 63243457
Renal adenoma 10.40 9.91 3 245556 6 63243457
Haemorrhagic fever 10.40 9.91 3 245556 6 63243457
Arcus lipoides 10.40 9.91 3 245556 6 63243457
Wrong patient received product 10.40 9.91 25 245534 2182 63241281
Reflexes abnormal 10.39 9.91 13 245546 668 63242795
Ejection fraction decreased 10.36 9.91 132 245427 22200 63221263
Gastric cyst 10.36 9.91 6 245553 103 63243360
Skin candida 10.35 9.91 21 245538 1634 63241829
Drug therapeutic incompatibility 10.35 9.91 5 245554 58 63243405
Transplant dysfunction 10.33 9.91 3 245556 4869 63238594
Chronic pigmented purpura 10.33 9.91 7 245552 160 63243303
Pulmonary embolism 10.30 9.91 551 245008 116133 63127330
Nodule 10.30 9.91 44 245515 20982 63222481
Mesenteric arterial occlusion 10.29 9.91 7 245552 161 63243302
Low density lipoprotein abnormal 10.28 9.91 8 245551 228 63243235
Cardiac failure chronic 10.27 9.91 39 245520 4379 63239084
Oral herpes 10.22 9.91 59 245500 26015 63217448
Blood pressure diastolic abnormal 10.19 9.91 26 245533 14516 63228947
Bronchopulmonary aspergillosis 10.18 9.91 11 245548 8624 63234839
Sweat gland tumour 10.15 9.91 6 245553 107 63243356
Hypersensitivity vasculitis 10.15 9.91 37 245522 4075 63239388
Gastrointestinal toxicity 10.12 9.91 9 245550 7732 63235731
Muscle contractions involuntary 10.12 9.91 26 245533 2366 63241097
Auricular swelling 10.06 9.91 5 245554 62 63243401
Benign neoplasm of bladder 10.03 9.91 4 245555 28 63243435
Pseudomonas bronchitis 10.03 9.91 4 245555 28 63243435
Skin laceration 10.02 9.91 133 245426 22575 63220888
Intestinal ischaemia 9.96 9.91 56 245503 7412 63236051
Product commingling 9.96 9.91 7 245552 170 63243293
Cardiac failure acute 9.92 9.91 67 245492 9456 63234007

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 2696.85 11.25 2836 242940 65327 34645828
Myalgia 1224.13 11.25 2152 243624 81958 34629197
Blood creatine phosphokinase increased 731.28 11.25 1208 244568 43649 34667506
Off label use 673.95 11.25 1203 244573 418321 34292834
Drug ineffective 600.46 11.25 1468 244308 455283 34255872
Myopathy 525.15 11.25 519 245257 11035 34700120
Drug interaction 430.26 11.25 2888 242888 223058 34488097
Drug abuse 429.48 11.25 87 245689 99009 34612146
Myocardial infarction 329.89 11.25 1702 244074 119383 34591772
Febrile neutropenia 300.79 11.25 311 245465 136538 34574617
Acute kidney injury 288.72 11.25 3343 242433 301645 34409510
Product use in unapproved indication 272.04 11.25 255 245521 117244 34593911
Toxicity to various agents 261.83 11.25 644 245132 199718 34511437
Coronary artery disease 239.37 11.25 816 244960 47489 34663666
Tendon rupture 235.14 11.25 268 245508 6744 34704411
Foetal exposure during pregnancy 221.90 11.25 11 245765 38090 34673065
Myositis 221.07 11.25 343 245433 11727 34699428
Muscular weakness 195.02 11.25 1020 244756 71877 34639278
Death 194.00 11.25 1828 243948 396221 34314934
Treatment failure 178.82 11.25 53 245723 46644 34664511
Cerebrovascular accident 175.95 11.25 1109 244667 83702 34627453
Neutropenia 172.63 11.25 547 245229 156231 34554924
Pyrexia 152.89 11.25 1551 244225 331462 34379693
Dizziness 150.06 11.25 2261 243515 216260 34494895
Syncope 148.37 11.25 1126 244650 90325 34620830
Immune-mediated myositis 136.66 11.25 115 245661 1968 34709187
General physical health deterioration 133.49 11.25 1434 244342 126835 34584320
Angina pectoris 131.65 11.25 502 245274 30861 34680294
Therapeutic product effect incomplete 126.17 11.25 102 245674 50439 34660716
Muscle rupture 117.17 11.25 110 245666 2188 34708967
Drug resistance 115.96 11.25 21 245755 25906 34685249
Infusion related reaction 111.49 11.25 125 245651 52932 34658223
Cytomegalovirus infection 106.96 11.25 26 245750 26109 34685046
Chromaturia 106.69 11.25 282 245494 14238 34696917
Product use issue 105.57 11.25 176 245600 63040 34648115
Premature baby 101.82 11.25 10 245766 19623 34691532
Malignant neoplasm progression 101.21 11.25 301 245475 87745 34623410
Liver function test abnormal 101.09 11.25 460 245316 30614 34680541
Transient ischaemic attack 100.67 11.25 423 245353 27190 34683965
International normalised ratio increased 100.64 11.25 623 245153 46704 34664451
Cardiac failure congestive 100.50 11.25 960 244816 82310 34628845
Intentional product use issue 97.61 11.25 169 245607 59647 34651508
Hospitalisation 92.64 11.25 161 245615 56741 34654414
Septic shock 90.41 11.25 235 245541 71599 34639556
Pneumonia 88.18 11.25 1912 243864 360715 34350440
Myocardial ischaemia 85.22 11.25 293 245483 17115 34694040
Drug dependence 84.81 11.25 32 245744 24185 34686970
Asthenia 83.27 11.25 2285 243491 242966 34468189
Fall 82.61 11.25 1937 243839 200948 34510207
Chest pain 81.20 11.25 1297 244479 125465 34585690
Lip swelling 80.78 11.25 273 245503 15807 34695348
Muscle spasms 80.50 11.25 844 244932 74157 34636998
Self esteem decreased 80.21 11.25 49 245727 490 34710665
Product dose omission issue 79.44 11.25 504 245272 119207 34591948
Acute myocardial infarction 78.56 11.25 646 245130 53073 34658082
COVID-19 77.45 11.25 282 245494 77268 34633887
Drug reaction with eosinophilia and systemic symptoms 74.71 11.25 73 245703 32939 34678216
Blood glucose increased 74.06 11.25 756 245020 65962 34645193
Disease progression 73.79 11.25 451 245325 107626 34603529
Product prescribing error 72.78 11.25 337 245439 22590 34688565
Drug ineffective for unapproved indication 72.57 11.25 38 245738 23677 34687478
Myelosuppression 71.69 11.25 23 245753 19242 34691913
Angioedema 70.27 11.25 477 245299 36897 34674258
Bronchopulmonary aspergillosis 69.76 11.25 10 245766 14649 34696506
Mucosal inflammation 68.75 11.25 103 245673 38519 34672636
Thrombocytopenia 66.84 11.25 739 245037 155508 34555647
Gastrointestinal haemorrhage 66.65 11.25 931 244845 87546 34623609
Pancytopenia 66.57 11.25 394 245382 94763 34616392
Inappropriate schedule of product administration 65.92 11.25 221 245555 62075 34649080
Pneumocystis jirovecii pneumonia 65.82 11.25 28 245748 19682 34691473
Sleep terror 63.59 11.25 80 245696 2238 34708917
Cardiospasm 62.45 11.25 66 245710 1522 34709633
Balance disorder 62.20 11.25 494 245282 40160 34670995
Nasopharyngitis 61.87 11.25 267 245509 69701 34641454
Rheumatoid arthritis 60.59 11.25 110 245666 38128 34673027
Carotid artery occlusion 59.94 11.25 100 245676 3637 34707518
Oxygen saturation decreased 59.66 11.25 187 245589 53631 34657524
Dyspnoea 58.00 11.25 3219 242557 373563 34337592
Quality of life decreased 57.53 11.25 102 245674 3899 34707256
Completed suicide 57.34 11.25 429 245347 97739 34613416
Leukopenia 56.72 11.25 238 245538 62618 34648537
Amnesia 56.03 11.25 349 245427 26214 34684941
Hepatic function abnormal 55.90 11.25 145 245631 44218 34666937
Pruritus genital 55.64 11.25 73 245703 2131 34709024
Confusional state 55.15 11.25 1365 244411 142795 34568360
Tension headache 55.07 11.25 86 245690 2956 34708199
Idiopathic pulmonary fibrosis 53.29 11.25 92 245684 3442 34707713
Condition aggravated 52.63 11.25 993 244783 191203 34519952
Coma 52.57 11.25 156 245620 45522 34665633
Coronary artery stenosis 52.55 11.25 168 245608 9448 34701707
Product monitoring error 52.15 11.25 103 245673 4278 34706877
Bone marrow failure 52.08 11.25 78 245698 29175 34681980
Therapeutic drug monitoring analysis not performed 51.79 11.25 38 245738 527 34710628
Dermatomyositis 51.66 11.25 54 245722 1229 34709926
Palmoplantar keratoderma 51.36 11.25 66 245710 1887 34709268
Intentional overdose 51.10 11.25 148 245628 43526 34667629
Subdural haemorrhage 50.66 11.25 85 245691 3106 34708049
Coronary artery occlusion 50.62 11.25 181 245595 10781 34700374
Muscle atrophy 49.59 11.25 139 245637 7265 34703890
Agranulocytosis 49.07 11.25 57 245719 23764 34687391
Orthostatic intolerance 49.03 11.25 43 245733 780 34710375
Pathogen resistance 48.72 11.25 5 245771 9477 34701678
Amyotrophic lateral sclerosis 48.62 11.25 47 245729 971 34710184
Cytokine release syndrome 47.93 11.25 54 245722 22823 34688332
Renal failure 47.21 11.25 1227 244549 129330 34581825
Gait disturbance 47.13 11.25 851 244925 84289 34626866
Atrial fibrillation 47.12 11.25 1160 244616 121233 34589922
Synovitis 46.94 11.25 20 245756 14046 34697109
Infection 46.80 11.25 411 245365 90504 34620651
Appendicolith 46.76 11.25 150 245626 8451 34702704
Palpitations 46.72 11.25 458 245318 39528 34671627
Myoglobinuria 46.61 11.25 41 245735 747 34710408
Respiratory depression 45.48 11.25 29 245747 16216 34694939
Lactic acidosis 44.98 11.25 407 245369 34365 34676790
Hypoglycaemia 44.84 11.25 584 245192 54056 34657099
Social problem 44.77 11.25 43 245733 881 34710274
Circulatory collapse 44.73 11.25 277 245499 20761 34690394
Immunisation 44.57 11.25 46 245730 1031 34710124
Venoocclusive liver disease 44.23 11.25 3 245773 7963 34703192
Hyperkalaemia 44.00 11.25 709 245067 68680 34642475
Blood creatinine increased 43.99 11.25 924 244852 94052 34617103
Atrial tachycardia 43.75 11.25 86 245690 3559 34707596
Blood urea abnormal 43.75 11.25 40 245736 768 34710387
Dehydration 43.43 11.25 1209 244567 128760 34582395
Poisoning deliberate 43.42 11.25 3 245773 7841 34703314
Angina unstable 42.84 11.25 179 245597 11474 34699681
Stomatitis 42.82 11.25 154 245622 42360 34668795
Thrombotic microangiopathy 42.67 11.25 11 245765 10619 34700536
Haemophagocytic lymphohistiocytosis 42.42 11.25 19 245757 12954 34698201
Pseudomonas infection 42.30 11.25 17 245759 12365 34698790
Therapy non-responder 42.00 11.25 138 245638 39008 34672147
Epstein-Barr virus infection 41.99 11.25 3 245773 7625 34703530
Cardiovascular disorder 41.39 11.25 160 245616 9896 34701259
Low birth weight baby 41.06 11.25 4 245772 7901 34703254
Erectile dysfunction 40.96 11.25 267 245509 20370 34690785
Nightmare 40.95 11.25 205 245571 14186 34696969
Transplant rejection 40.76 11.25 11 245765 10300 34700855
Posterior reversible encephalopathy syndrome 40.54 11.25 10 245766 9944 34701211
Anosmia 40.16 11.25 88 245688 3936 34707219
Abnormal dreams 40.15 11.25 131 245645 7447 34703708
Pancreatitis acute 39.83 11.25 336 245440 27805 34683350
Haematuria 39.37 11.25 531 245245 49535 34661620
Neutrophil count decreased 39.32 11.25 205 245571 50899 34660256
Cardio-respiratory arrest 39.09 11.25 228 245548 55045 34656110
White blood cell count decreased 38.97 11.25 456 245320 94989 34616166
Neoplasm progression 38.75 11.25 65 245711 23235 34687920
Tumour lysis syndrome 38.28 11.25 38 245738 17021 34694134
Haematotoxicity 38.04 11.25 6 245770 8188 34702967
Cytopenia 38.03 11.25 21 245755 12702 34698453
Blood pressure fluctuation 37.07 11.25 76 245700 25173 34685982
Aspergillus infection 36.96 11.25 20 245756 12234 34698921
Substance abuse 36.86 11.25 5 245771 7636 34703519
Platelet count decreased 36.72 11.25 606 245170 119111 34592044
Influenza 36.67 11.25 202 245574 49464 34661691
Suicide attempt 35.97 11.25 147 245629 38969 34672186
Facial pain 35.83 11.25 80 245696 3624 34707531
Joint swelling 35.78 11.25 260 245516 59630 34651525
Pain in extremity 35.55 11.25 1152 244624 125361 34585794
Muscle disorder 35.37 11.25 65 245711 2556 34708599
Muscle necrosis 35.15 11.25 37 245739 849 34710306
Actinic keratosis 34.88 11.25 90 245686 4477 34706678
Ischaemic cardiomyopathy 34.35 11.25 111 245665 6278 34704877
Accidental exposure to product 34.29 11.25 24 245752 12778 34698377
Swollen tongue 34.06 11.25 197 245579 14408 34696747
Subarachnoid haemorrhage 33.87 11.25 177 245599 12458 34698697
Injection site pain 33.77 11.25 150 245626 38855 34672300
Immune reconstitution inflammatory syndrome 33.41 11.25 10 245766 8749 34702406
Bradycardia 33.39 11.25 729 245047 74689 34636466
Tendonitis 33.29 11.25 140 245636 9000 34702155
Therapeutic response shortened 33.10 11.25 6 245770 7398 34703757
Asthma 32.87 11.25 171 245605 42485 34668670
Ventricular tachycardia 32.30 11.25 307 245469 26272 34684883
Obstructive airways disorder 31.99 11.25 37 245739 15457 34695698
Naevus flammeus 31.96 11.25 19 245757 180 34710975
Contraindicated product prescribed 31.51 11.25 25 245751 392 34710763
Carotid artery stenosis 31.45 11.25 92 245684 4927 34706228
Myoglobin blood increased 31.18 11.25 67 245709 2956 34708199
Atrial septal defect 30.94 11.25 7 245769 7385 34703770
Haemodialysis 30.70 11.25 151 245625 10375 34700780
Pancreatitis necrotising 30.63 11.25 63 245713 2695 34708460
Encephalopathy 30.47 11.25 136 245640 35183 34675972
Clostridium difficile infection 30.26 11.25 54 245722 18844 34692311
Altered state of consciousness 30.25 11.25 73 245703 22820 34688335
Hepatitis C 29.71 11.25 16 245760 9814 34701341
Disseminated intravascular coagulation 29.28 11.25 69 245707 21747 34689408
Pelvic mass 29.21 11.25 19 245757 214 34710941
Aplastic anaemia 29.09 11.25 16 245760 9700 34701455
Pulmonary fibrosis 28.93 11.25 225 245551 18171 34692984
Productive cough 28.90 11.25 152 245624 37661 34673494
Psychiatric symptom 28.67 11.25 71 245705 3442 34707713
Lymphopenia 28.64 11.25 44 245732 16291 34694864
Bursitis 28.60 11.25 94 245682 5364 34705791
Febrile bone marrow aplasia 28.49 11.25 11 245765 8198 34702957
Serotonin syndrome 28.42 11.25 61 245715 19872 34691283
Hepatic encephalopathy 28.29 11.25 37 245739 14648 34696507
Overdose 28.22 11.25 460 245316 90599 34620556
Mucosal haemorrhage 28.12 11.25 45 245731 1580 34709575
Blood urea increased 28.12 11.25 332 245444 30032 34681123
Ischaemic stroke 28.03 11.25 222 245554 18028 34693127
Gait inability 27.88 11.25 245 245531 20513 34690642
Drug intolerance 27.76 11.25 276 245500 59294 34651861
Myxoedema coma 27.71 11.25 20 245756 270 34710885
Hypogammaglobulinaemia 27.48 11.25 10 245766 7730 34703425
Pain of skin 27.47 11.25 100 245676 6009 34705146
Adrenal insufficiency 27.46 11.25 35 245741 14012 34697143
Muscle twitching 27.42 11.25 144 245632 10154 34701001
Faeces pale 27.28 11.25 41 245735 1362 34709793
Intestinal obstruction 26.94 11.25 77 245699 22745 34688410
Oedema mouth 26.93 11.25 39 245737 1252 34709903
Seizure 26.75 11.25 548 245228 104309 34606846
Injury 26.68 11.25 242 245534 20445 34690710
Neurotoxicity 26.62 11.25 54 245722 17956 34693199
Respiratory failure 26.36 11.25 572 245204 108000 34603155
Blood glucose fluctuation 26.18 11.25 75 245701 3969 34707186
Status epilepticus 26.18 11.25 30 245746 12584 34698571
Illness 26.15 11.25 34 245742 13495 34697660
Myopathy toxic 26.02 11.25 26 245750 560 34710595
Atrioventricular block complete 25.99 11.25 132 245644 9187 34701968
Urogenital haemorrhage 25.87 11.25 29 245747 716 34710439
Gastritis erosive 25.75 11.25 96 245680 5836 34705319
Cytomegalovirus viraemia 25.71 11.25 10 245766 7420 34703735
Fear 25.54 11.25 143 245633 10333 34700822
Lymphocyte count decreased 25.49 11.25 78 245698 22544 34688611
Actinic elastosis 25.47 11.25 11 245765 48 34711107
Therapeutic product effect decreased 25.27 11.25 142 245634 34601 34676554
Pancreatitis 25.25 11.25 399 245377 38492 34672663
Transient global amnesia 25.21 11.25 21 245755 354 34710801
Bacteraemia 25.17 11.25 64 245712 19653 34691502
No adverse event 25.16 11.25 80 245696 22847 34688308
Orthostatic hypotension 25.16 11.25 286 245490 25633 34685522
Atrioventricular block first degree 25.13 11.25 97 245679 5995 34705160
Polymyositis 24.82 11.25 40 245736 1413 34709742
Akathisia 24.80 11.25 13 245763 8096 34703059
Weight increased 24.69 11.25 483 245293 92550 34618605
Neuropathy peripheral 24.69 11.25 424 245352 82839 34628316
Cystitis haemorrhagic 24.54 11.25 5 245771 5674 34705481
Hyperbilirubinaemia 24.47 11.25 51 245725 16792 34694363
Stress 24.32 11.25 323 245453 30024 34681131
Myasthenia gravis 24.27 11.25 105 245671 6835 34704320
Therapeutic response decreased 24.02 11.25 115 245661 29198 34681957
Hyponatraemia 23.99 11.25 756 245020 81935 34629220
Sedation 23.97 11.25 72 245704 20934 34690221
Diplopia 23.78 11.25 201 245575 16642 34694513
Poor venous access 23.61 11.25 4 245772 5179 34705976
Compartment syndrome 23.59 11.25 60 245716 2958 34708197
Alveolitis 23.47 11.25 43 245733 1687 34709468
Oesophageal obstruction 23.41 11.25 23 245753 485 34710670
Arteriosclerosis 23.23 11.25 154 245622 11814 34699341
Hyperthermia 23.23 11.25 24 245752 10553 34700602
Cytomegalovirus infection reactivation 23.20 11.25 4 245772 5114 34706041
Ventricular fibrillation 23.06 11.25 255 245521 22699 34688456
Hepatocellular carcinoma 23.02 11.25 12 245764 7497 34703658
BK virus infection 22.91 11.25 6 245770 5732 34705423
Product complaint 22.85 11.25 92 245684 5798 34705357
Dialysis 22.85 11.25 146 245630 11062 34700093
Klebsiella infection 22.84 11.25 16 245760 8515 34702640
Blood electrolytes abnormal 22.81 11.25 31 245745 937 34710218
Tenderness 22.80 11.25 103 245673 6831 34704324
Necrotising myositis 22.66 11.25 26 245750 659 34710496
Diverticulum 22.55 11.25 105 245671 7054 34704101
Osteochondrosis 22.39 11.25 33 245743 1077 34710078
Renal injury 22.31 11.25 145 245631 11050 34700105
Disease recurrence 22.20 11.25 77 245699 21413 34689742
Ankylosing spondylitis 22.11 11.25 6 245770 5598 34705557
Nocturia 22.06 11.25 135 245641 10075 34701080
Hyperlipidaemia 21.91 11.25 176 245600 14353 34696802
Abdominal pain lower 21.73 11.25 138 245638 10433 34700722
Brain oedema 21.68 11.25 40 245736 13781 34697374
Mitochondrial myopathy 21.58 11.25 15 245761 190 34710965
Eye pruritus 21.53 11.25 107 245669 7382 34703773
Acute coronary syndrome 21.48 11.25 166 245610 13379 34697776
Loss of personal independence in daily activities 21.31 11.25 141 245635 33038 34678117
Respiratory arrest 21.28 11.25 113 245663 27930 34683225
Granuloma annulare 21.28 11.25 14 245762 161 34710994
Blood pressure systolic increased 21.26 11.25 86 245690 22866 34688289
Biliary cirrhosis 21.08 11.25 12 245764 104 34711051
Hepatic cytolysis 20.97 11.25 44 245732 14452 34696703
Asphyxia 20.84 11.25 11 245765 6824 34704331
Ejaculation failure 20.74 11.25 27 245749 782 34710373
Syringe issue 20.66 11.25 7 245769 5657 34705498
Wrong technique in product usage process 20.64 11.25 158 245618 35828 34675327
Acute myeloid leukaemia 20.58 11.25 63 245713 18207 34692948
Sepsis 20.57 11.25 959 244817 165602 34545553
Mitochondrial myopathy acquired 20.49 11.25 7 245769 13 34711142
Brain scan abnormal 20.46 11.25 28 245748 852 34710303
Tinnitus 20.44 11.25 224 245552 19894 34691261
Hiatus hernia 20.42 11.25 107 245669 7538 34703617
Psoriatic arthropathy 20.41 11.25 71 245705 19727 34691428
Respiratory tract haemorrhage 20.39 11.25 34 245742 1236 34709919
Thrombotic thrombocytopenic purpura 20.38 11.25 61 245715 3309 34707846
Contusion 20.28 11.25 364 245412 36000 34675155
Glycosylated haemoglobin increased 20.17 11.25 143 245633 11217 34699938
Duodenal ulcer 20.09 11.25 133 245643 10199 34700956
Appendicitis 20.01 11.25 175 245601 14632 34696523
Haematoma 19.89 11.25 271 245505 25334 34685821
Myoglobin urine 19.84 11.25 7 245769 15 34711140
Upper motor neurone lesion 19.81 11.25 12 245764 118 34711037
Personality change 19.72 11.25 80 245696 5059 34706096
Occupational problem environmental 19.67 11.25 6 245770 6 34711149
Avoidant personality disorder 19.67 11.25 6 245770 6 34711149
Pemphigoid 19.63 11.25 116 245660 8550 34702605
Atrioventricular block 19.61 11.25 110 245666 7953 34703202
High density lipoprotein decreased 19.55 11.25 60 245716 3300 34707855
Viral myositis 19.54 11.25 7 245769 16 34711139
Potentiating drug interaction 19.52 11.25 78 245698 4899 34706256
Pallor 19.51 11.25 269 245507 25211 34685944
Social avoidant behaviour 19.44 11.25 57 245719 3057 34708098
Pneumonia fungal 19.43 11.25 13 245763 7087 34704068
Hypoalbuminaemia 19.30 11.25 35 245741 12139 34699016
Full blood count abnormal 19.21 11.25 67 245709 18601 34692554
Pneumonia aspiration 19.16 11.25 195 245581 41708 34669447
Lung disorder 19.12 11.25 154 245622 34542 34676613
Hypertensive crisis 19.09 11.25 116 245660 8635 34702520
Spinal cord haemorrhage 19.05 11.25 17 245759 316 34710839
Enterocolitis 19.04 11.25 17 245759 8009 34703146
Device related infection 19.02 11.25 60 245716 17177 34693978
Lethargy 18.99 11.25 400 245376 40722 34670433
Emotional distress 18.98 11.25 175 245601 14851 34696304
Intentional product misuse 18.95 11.25 217 245559 45394 34665761
Renal cyst 18.87 11.25 119 245657 8974 34702181
Malnutrition 18.87 11.25 38 245738 12671 34698484
Prostate cancer recurrent 18.84 11.25 29 245747 984 34710171
Anhedonia 18.80 11.25 104 245672 7481 34703674
Sickle cell anaemia with crisis 18.74 11.25 3 245773 4050 34707105
Respiratory syncytial virus infection 18.66 11.25 5 245771 4704 34706451
Therapy interrupted 18.64 11.25 43 245733 13654 34697501
Myoglobin urine present 18.61 11.25 13 245763 166 34710989
Blood glucose abnormal 18.53 11.25 87 245689 5865 34705290
Ventricular septal defect 18.42 11.25 3 245773 3998 34707157
Frequent bowel movements 18.34 11.25 39 245737 12748 34698407
Impaired quality of life 18.28 11.25 9 245767 5809 34705346
Carcinogenicity 18.28 11.25 9 245767 56 34711099
Platelet count normal 18.20 11.25 7 245769 21 34711134
Oedema peripheral 18.18 11.25 1023 244753 118789 34592366
Arteriosclerosis coronary artery 18.16 11.25 150 245626 12335 34698820
Acquired claw toe 18.16 11.25 8 245768 37 34711118
Spinal osteoarthritis 18.15 11.25 104 245672 7579 34703576
Periarthritis calcarea 18.13 11.25 10 245766 81 34711074
Hypoglycaemic unconsciousness 17.97 11.25 25 245751 773 34710382
Incorrect dose administered 17.93 11.25 190 245586 40325 34670830
Sinus bradycardia 17.93 11.25 154 245622 12809 34698346
Type 2 diabetes mellitus 17.93 11.25 182 245594 15850 34695305
Interstitial lung disease 17.91 11.25 337 245439 64945 34646210
Sudden cardiac death 17.85 11.25 62 245714 3639 34707516
Abdominal pain upper 17.79 11.25 642 245134 70848 34640307
Poisoning 17.78 11.25 37 245739 12189 34698966
Arrhythmia 17.76 11.25 352 245424 35456 34675699
Osteonecrosis 17.75 11.25 50 245726 14840 34696315
Lichen planus 17.75 11.25 28 245748 971 34710184
Malignant spinal cord compression 17.74 11.25 12 245764 145 34711010
Hepatitis B 17.70 11.25 10 245766 5973 34705182
Feeding disorder 17.67 11.25 14 245762 6996 34704159
Eosinophilia 17.57 11.25 110 245666 26112 34685043
Hypoxia 17.50 11.25 277 245499 54818 34656337
Nephrolithiasis 17.48 11.25 133 245643 30200 34680955
Central nervous system lesion 17.47 11.25 12 245764 6451 34704704
Vascular device infection 17.44 11.25 4 245772 4181 34706974
Rash 17.44 11.25 1339 244437 221413 34489742
Aortic valve sclerosis 17.43 11.25 28 245748 986 34710169
Chronic obstructive pulmonary disease 17.43 11.25 459 245317 48459 34662696
Haemorrhage intracranial 17.34 11.25 180 245596 15766 34695389
Ischaemia 17.34 11.25 71 245705 4509 34706646
Extremity necrosis 17.32 11.25 41 245735 1931 34709224
Multiple injuries 17.30 11.25 40 245736 1855 34709300
Serum ferritin abnormal 17.21 11.25 14 245762 228 34710927
Gastritis 17.19 11.25 232 245544 21641 34689514
Cerebral haemorrhage 17.18 11.25 343 245433 34594 34676561
Blood glucose decreased 17.14 11.25 155 245621 13082 34698073
Vasculitis 17.12 11.25 137 245639 11159 34699996
Low density lipoprotein increased 16.98 11.25 69 245707 4367 34706788
Contracted bladder 16.96 11.25 6 245770 13 34711142
Swelling face 16.92 11.25 242 245534 22863 34688292
Cerebral artery thrombosis 16.91 11.25 24 245752 756 34710399
Blood loss anaemia 16.86 11.25 107 245669 8087 34703068
Ventricular extrasystoles 16.79 11.25 143 245633 11865 34699290
Raynaud's phenomenon 16.75 11.25 15 245761 280 34710875
Peripheral vascular disorder 16.70 11.25 75 245701 4961 34706194
Liver disorder 16.60 11.25 150 245626 32847 34678308
Intentional self-injury 16.59 11.25 46 245730 13725 34697430
Depressed level of consciousness 16.58 11.25 207 245569 42634 34668521
Dilatation atrial 16.47 11.25 41 245735 1994 34709161
Pleurothotonus 16.41 11.25 30 245746 1175 34709980
Cognitive disorder 16.28 11.25 288 245488 28405 34682750
Gynaecomastia 16.28 11.25 125 245651 10055 34701100
Subdural haematoma 16.22 11.25 217 245559 20204 34690951
Herpes zoster 16.18 11.25 159 245617 34240 34676915
Hemiparesis 16.18 11.25 176 245600 15602 34695553
Angioplasty 16.16 11.25 27 245749 983 34710172
Maternal drugs affecting foetus 16.11 11.25 4 245772 3961 34707194
Anal fistula 16.01 11.25 9 245767 5390 34705765
Coagulation time prolonged 15.97 11.25 31 245745 1271 34709884
Small for dates baby 15.88 11.25 4 245772 3923 34707232
Lipase increased 15.83 11.25 117 245659 9299 34701856
Blindness 15.75 11.25 168 245608 14818 34696337
Sleep attacks 15.72 11.25 11 245765 141 34711014
Hyperammonaemia 15.69 11.25 13 245763 6354 34704801
Cytomegalovirus test positive 15.64 11.25 4 245772 3882 34707273
Hyperhidrosis 15.61 11.25 666 245110 75026 34636129
Radiation inflammation 15.57 11.25 25 245751 880 34710275
Muscle discomfort 15.57 11.25 10 245766 110 34711045
Injected limb mobility decreased 15.49 11.25 5 245771 7 34711148
Pulmonary tuberculosis 15.48 11.25 7 245769 4747 34706408
Infusion site pain 15.43 11.25 4 245772 3847 34707308
Carpal tunnel syndrome 15.39 11.25 70 245706 4656 34706499
Haematemesis 15.32 11.25 277 245499 27434 34683721
Intermittent claudication 15.30 11.25 43 245733 2251 34708904
Hepatic enzyme decreased 15.24 11.25 8 245768 58 34711097
C-reactive protein increased 15.23 11.25 278 245498 53820 34657335
Articular calcification 15.16 11.25 9 245767 85 34711070
Second primary malignancy 15.05 11.25 20 245756 7866 34703289
Pneumothorax 15.01 11.25 76 245700 19016 34692139
Haematochezia 14.99 11.25 431 245345 46103 34665052
Angioimmunoblastic T-cell lymphoma 14.98 11.25 15 245761 324 34710831
Stent placement 14.92 11.25 73 245703 5005 34706150
Gingival recession 14.90 11.25 17 245759 428 34710727
Rash maculo-papular 14.90 11.25 128 245648 28323 34682832
Therapy cessation 14.85 11.25 65 245711 16908 34694247
Ventricular hypertrophy 14.82 11.25 68 245708 4539 34706616
Areflexia 14.82 11.25 51 245725 2980 34708175
Pneumonia bacterial 14.80 11.25 39 245737 11833 34699322
Periprosthetic fracture 14.79 11.25 11 245765 156 34710999
Carcinoma in situ 14.74 11.25 5 245771 9 34711146
Blood lactic acid 14.72 11.25 15 245761 331 34710824
Device issue 14.72 11.25 29 245747 9748 34701407
Lichen myxoedematosus 14.70 11.25 6 245770 22 34711133
Diabetes mellitus inadequate control 14.65 11.25 152 245624 13312 34697843
Duodenitis 14.61 11.25 70 245706 4758 34706397
Bone erosion 14.58 11.25 5 245771 4010 34707145
Rhinorrhoea 14.57 11.25 113 245663 25555 34685600
Aplasia 14.56 11.25 7 245769 4581 34706574
Mitral valve incompetence 14.55 11.25 165 245611 14778 34696377
Pneumonitis 14.54 11.25 160 245616 33718 34677437
Vasculitic rash 14.50 11.25 25 245751 934 34710221
Shock hypoglycaemic 14.49 11.25 9 245767 93 34711062
Drug withdrawal syndrome 14.45 11.25 81 245695 19753 34691402
Exercise lack of 14.43 11.25 10 245766 126 34711029
Melaena 14.40 11.25 338 245438 35042 34676113
Exposure to toxic agent 14.38 11.25 4 245772 3671 34707484
Blood pressure diastolic abnormal 14.33 11.25 8 245768 4810 34706345
Hepatitis 14.31 11.25 242 245534 23662 34687493
Tongue oedema 14.28 11.25 50 245726 2947 34708208
Accidental overdose 14.27 11.25 83 245693 20057 34691098
Blood potassium increased 14.24 11.25 178 245598 16317 34694838
Sinusitis 14.23 11.25 205 245571 41197 34669958
Bradyphrenia 14.22 11.25 8 245768 4790 34706365
Impatience 14.22 11.25 15 245761 345 34710810
Candida infection 14.22 11.25 70 245706 17645 34693510
Blood pressure systolic abnormal 14.19 11.25 5 245771 3943 34707212
Blood pressure orthostatic 14.18 11.25 8 245768 68 34711087
Mydriasis 14.18 11.25 18 245758 7219 34703936
Musculoskeletal toxicity 14.10 11.25 10 245766 131 34711024
Hepatic failure 14.07 11.25 165 245611 34366 34676789
Drug specific antibody present 13.97 11.25 3 245773 3282 34707873
Arteriosclerotic gangrene 13.90 11.25 8 245768 71 34711084
Aphasia 13.88 11.25 220 245556 21234 34689921
Cytomegalovirus chorioretinitis 13.87 11.25 4 245772 3585 34707570
Basal ganglia haemorrhage 13.82 11.25 24 245752 902 34710253
Methaemoglobinaemia 13.82 11.25 4 245772 3577 34707578
Progressive multifocal leukoencephalopathy 13.82 11.25 30 245746 9734 34701421
Miosis 13.74 11.25 29 245747 9506 34701649
Polycystic liver disease 13.71 11.25 9 245767 103 34711052
Oesophageal carcinoma 13.66 11.25 28 245748 9276 34701879
Rash papular 13.64 11.25 121 245655 10157 34700998
Social fear 13.64 11.25 4 245772 3 34711152
Glycogen storage disease type II 13.64 11.25 4 245772 3 34711152
Aortic aneurysm 13.63 11.25 88 245688 6691 34704464
Blood phosphorus increased 13.59 11.25 97 245679 7624 34703531
Eosinophilic cystitis 13.58 11.25 6 245770 28 34711127
Wheezing 13.54 11.25 207 245569 41195 34669960
Pseudoporphyria 13.49 11.25 15 245761 367 34710788
Muscle fatigue 13.46 11.25 31 245745 1434 34709721
Coordination abnormal 13.44 11.25 96 245680 7548 34703607
Electrocardiogram abnormal 13.40 11.25 111 245665 9136 34702019
Portal fibrosis 13.38 11.25 14 245762 319 34710836
Fungal infection 13.36 11.25 62 245714 15873 34695282
Blood creatine phosphokinase 13.36 11.25 9 245767 108 34711047
Cardiotoxicity 13.35 11.25 12 245764 5636 34705519
Cardiogenic shock 13.31 11.25 262 245514 26356 34684799
Ureteric injury 13.31 11.25 7 245769 51 34711104
Colitis 13.30 11.25 186 245590 37564 34673591
Tuberculosis 13.29 11.25 25 245751 8552 34702603
Dystonia 13.24 11.25 36 245740 10809 34700346
Complications of transplanted kidney 13.22 11.25 8 245768 4601 34706554
Cholecystitis chronic 13.20 11.25 23 245753 867 34710288
Urinary incontinence 13.15 11.25 196 245580 18678 34692477
Puncture site haematoma 13.14 11.25 10 245766 147 34711008
Abscess 13.13 11.25 41 245735 11776 34699379
Quadriparesis 13.11 11.25 32 245744 1537 34709618
Pharyngeal oedema 13.09 11.25 80 245696 5967 34705188
Gallbladder neoplasm 13.09 11.25 6 245770 31 34711124
Electrolyte depletion 13.08 11.25 11 245765 188 34710967
Nephropathy toxic 13.07 11.25 45 245731 12543 34698612
Gout 13.05 11.25 199 245577 19054 34692101
Rotator cuff syndrome 13.04 11.25 76 245700 5573 34705582
Pancreatitis chronic 13.03 11.25 40 245736 2200 34708955
Electromyogram abnormal 12.98 11.25 7 245769 54 34711101
Lichenoid keratosis 12.97 11.25 43 245733 2465 34708690
Splenic necrosis 12.88 11.25 9 245767 115 34711040
Vitamin B complex deficiency 12.86 11.25 15 245761 387 34710768
Blood bilirubin abnormal 12.84 11.25 21 245755 751 34710404
Myocarditis 12.84 11.25 51 245725 13631 34697524
Adrenal cyst 12.81 11.25 10 245766 153 34711002
Staphylococcal bacteraemia 12.78 11.25 25 245751 8427 34702728
Skin toxicity 12.77 11.25 9 245767 4775 34706380
AST/ALT ratio abnormal 12.76 11.25 5 245771 16 34711139
Myoglobinaemia 12.75 11.25 9 245767 117 34711038
Jaundice cholestatic 12.74 11.25 67 245709 4727 34706428
Blood pressure diastolic increased 12.71 11.25 10 245766 5015 34706140
Colorectal cancer 12.65 11.25 9 245767 4752 34706403
Barrett's oesophagus 12.62 11.25 16 245760 451 34710704
Systemic infection 12.61 11.25 71 245705 5141 34706014
Body temperature decreased 12.60 11.25 48 245728 12986 34698169
Uveitis 12.55 11.25 21 245755 7514 34703641
Macroenzyme creatine kinase 12.53 11.25 5 245771 17 34711138
Product packaging quantity issue 12.49 11.25 23 245753 906 34710249
Cerebral arteriosclerosis 12.48 11.25 17 245759 515 34710640
Apparent death 12.45 11.25 5 245771 3639 34707516
SARS-CoV-2 test positive 12.43 11.25 14 245762 5919 34705236
Hyperlactacidaemia 12.42 11.25 48 245728 2968 34708187
Overflow diarrhoea 12.37 11.25 6 245770 36 34711119
Coronary angioplasty 12.33 11.25 15 245761 405 34710750
Upper respiratory tract infection 12.32 11.25 161 245615 32898 34678257
Product storage error 12.30 11.25 24 245752 8098 34703057
Dental examination abnormal 12.24 11.25 4 245772 6 34711149
Blood creatine phosphokinase MB increased 12.23 11.25 35 245741 1851 34709304
Device leakage 12.22 11.25 17 245759 6558 34704597
Dry mouth 12.22 11.25 288 245488 29877 34681278
Erythema 12.21 11.25 505 245271 88275 34622880
Antipsychotic drug level decreased 12.21 11.25 24 245752 993 34710162
Erosive duodenitis 12.17 11.25 33 245743 1691 34709464
Epiglottitis 12.16 11.25 15 245761 411 34710744
Anuria 12.15 11.25 119 245657 10266 34700889
Haemoglobin urine present 12.14 11.25 9 245767 127 34711028
Iron binding capacity total increased 12.10 11.25 6 245770 38 34711117
Glycogen storage disease type V 12.10 11.25 6 245770 38 34711117
Diabetic neuropathy 12.09 11.25 60 245716 4137 34707018
Coronary artery thrombosis 12.05 11.25 38 245738 2121 34709034
Staphylococcal infection 12.05 11.25 160 245616 32600 34678555
Liver function test increased 12.01 11.25 57 245719 14508 34696647
Immature granulocyte count increased 11.90 11.25 9 245767 131 34711024
Musculoskeletal stiffness 11.88 11.25 244 245532 46436 34664719
Parkinson's disease 11.86 11.25 29 245747 1395 34709760
Dyspnoea exertional 11.85 11.25 393 245383 42886 34668269
Tendon operation 11.85 11.25 6 245770 40 34711115
Subacute hepatic failure 11.80 11.25 8 245768 97 34711058
Psychological trauma 11.79 11.25 11 245765 217 34710938
Tachypnoea 11.78 11.25 78 245698 18274 34692881
Faeces discoloured 11.77 11.25 158 245618 14720 34696435
Gastric cancer 11.75 11.25 17 245759 6452 34704703
Headache 11.75 11.25 1233 244543 199402 34511753
Respiratory fatigue 11.73 11.25 8 245768 98 34711057
Crush syndrome 11.72 11.25 7 245769 67 34711088
Hyperventilation 11.68 11.25 45 245731 2779 34708376
Forced expiratory volume decreased 11.61 11.25 4 245772 3199 34707956
Pancreatic duct stenosis 11.60 11.25 10 245766 177 34710978
Butterfly rash 11.60 11.25 8 245768 100 34711055
Rhinovirus infection 11.59 11.25 8 245768 4291 34706864
Impaired work ability 11.59 11.25 86 245690 6844 34704311
Neonatal respiratory distress syndrome 11.57 11.25 7 245769 4027 34707128
Breast tenderness 11.53 11.25 20 245756 751 34710404
Blood lactate dehydrogenase 11.52 11.25 4 245772 8 34711147
Carnitine palmitoyltransferase deficiency 11.52 11.25 4 245772 8 34711147
Toxic epidermal necrolysis 11.51 11.25 97 245679 21549 34689606
Mixed liver injury 11.48 11.25 3 245773 2870 34708285
Pseudoaldosteronism 11.46 11.25 7 245769 70 34711085
Vertebral artery stenosis 11.46 11.25 9 245767 139 34711016
COVID-19 pneumonia 11.46 11.25 71 245705 16896 34694259
Fistula 11.45 11.25 19 245757 6821 34704334
Venoocclusive disease 11.44 11.25 3 245773 2864 34708291
Epiglottic oedema 11.42 11.25 10 245766 181 34710974
Osteoma 11.40 11.25 8 245768 103 34711052
Myotonia 11.38 11.25 6 245770 44 34711111
Renal impairment 11.37 11.25 791 244985 93722 34617433
Tongue dry 11.31 11.25 11 245765 229 34710926
Hepatitis cholestatic 11.30 11.25 95 245681 7852 34703303
Retinal vascular thrombosis 11.29 11.25 7 245769 72 34711083
Volvulus 11.29 11.25 31 245745 1601 34709554

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rhabdomyolysis 4513.14 9.72 3922 400971 99209 79240286
Myalgia 1831.37 9.72 3337 401556 182304 79157191
Drug interaction 1346.52 9.72 4895 399998 410288 78929207
Blood creatine phosphokinase increased 1285.47 9.72 1631 403262 64459 79275036
Drug ineffective 1169.30 9.72 2336 402557 1078577 78260918
Myopathy 1012.40 9.72 838 404055 19725 79319770
Acute kidney injury 977.23 9.72 5202 399691 514202 78825293
Off label use 938.65 9.72 2009 402884 905206 78434289
Myocardial infarction 700.52 9.72 2292 402601 181837 79157658
Maternal exposure during pregnancy 514.94 9.72 49 404844 136489 79203006
Treatment failure 509.20 9.72 120 404773 170366 79169129
Synovitis 503.00 9.72 81 404812 150653 79188842
Coronary artery disease 480.35 9.72 1041 403852 64433 79275062
Infusion related reaction 457.83 9.72 303 404590 229934 79109561
Hand deformity 452.56 9.72 17 404876 103902 79235593
Systemic lupus erythematosus 425.31 9.72 56 404837 121093 79218402
Anti-cyclic citrullinated peptide antibody positive 404.53 9.72 3 404890 83140 79256355
Myositis 402.77 9.72 492 404401 18676 79320819
Pemphigus 385.57 9.72 32 404861 99550 79239945
Rheumatoid arthritis 369.72 9.72 309 404584 208161 79131334
Drug abuse 366.24 9.72 184 404709 162507 79176988
Syncope 364.01 9.72 1838 403055 177611 79161884
Cerebrovascular accident 348.96 9.72 1638 403255 153654 79185841
Immune-mediated myositis 348.23 9.72 218 404675 3249 79336246
Joint swelling 341.52 9.72 588 404305 288058 79051437
Product use in unapproved indication 337.33 9.72 467 404426 249892 79089603
Muscular weakness 337.09 9.72 1662 403231 159067 79180428
Product use issue 324.16 9.72 352 404541 209470 79130025
Fall 319.51 9.72 3831 401062 483798 78855697
Nasopharyngitis 319.15 9.72 497 404396 253384 79086111
Drug intolerance 318.91 9.72 531 404362 263588 79075907
Exposure during pregnancy 312.33 9.72 66 404827 101066 79238429
Therapeutic product effect decreased 310.60 9.72 227 404666 163636 79175859
Glossodynia 304.03 9.72 75 404818 103262 79236233
Febrile neutropenia 300.18 9.72 442 404451 230557 79108938
Tendon rupture 279.02 9.72 326 404567 11800 79327695
Product prescribing error 275.98 9.72 665 404228 44148 79295347
Dizziness 268.77 9.72 3953 400940 522488 78817007
International normalised ratio increased 254.17 9.72 976 403917 83745 79255750
Arthropathy 251.11 9.72 318 404575 176793 79162702
Hyponatraemia 250.14 9.72 1653 403240 176195 79163300
Transient ischaemic attack 246.82 9.72 706 404187 51989 79287506
Toxicity to various agents 233.35 9.72 1224 403669 420316 78919179
Gastrointestinal haemorrhage 231.88 9.72 1412 403481 146307 79193188
Duodenal ulcer perforation 231.40 9.72 31 404862 66180 79273315
Helicobacter infection 218.30 9.72 44 404849 69660 79269835
Lactic acidosis 214.70 9.72 815 404078 69544 79269951
Folliculitis 213.80 9.72 18 404875 55362 79284133
C-reactive protein abnormal 213.74 9.72 7 404886 48360 79291135
Atrial fibrillation 210.58 9.72 1721 403172 196165 79143330
Asthenia 209.56 9.72 3705 401188 507984 78831511
Hyperkalaemia 204.56 9.72 1132 403761 113266 79226229
Angioedema 204.03 9.72 846 404047 75189 79264306
Hypoglycaemia 204.01 9.72 1038 403855 100556 79238939
Renal failure 202.23 9.72 1726 403167 199242 79140253
Acute myocardial infarction 199.59 9.72 848 404045 76188 79263307
Liver function test abnormal 197.68 9.72 748 404145 63727 79275768
Sleep disorder due to general medical condition, insomnia type 197.26 9.72 5 404888 43551 79295944
Cardiac failure congestive 196.22 9.72 1317 403576 141085 79198410
Therapeutic product effect incomplete 190.87 9.72 264 404629 141381 79198114
Discomfort 190.33 9.72 214 404679 125403 79214092
Infection 189.90 9.72 612 404281 241100 79098395
Rheumatoid factor positive 184.85 9.72 39 404854 59800 79279695
Alopecia 184.39 9.72 582 404311 230773 79108722
Condition aggravated 177.71 9.72 1657 403236 499467 78840028
Stomatitis 176.12 9.72 296 404597 146461 79193034
Intentional product use issue 174.19 9.72 316 404577 151796 79187699
General physical health deterioration 173.53 9.72 2148 402745 273090 79066405
Sinusitis 172.34 9.72 469 404424 195032 79144463
Contraindicated product administered 171.85 9.72 337 404556 157201 79182294
Hypersensitivity 171.77 9.72 716 404177 261523 79077972
Product monitoring error 167.03 9.72 216 404677 8690 79330805
Angina pectoris 165.95 9.72 609 404284 51123 79288372
Swelling 165.17 9.72 556 404337 216155 79123340
Pyrexia 156.39 9.72 2465 402428 676244 78663251
Dehydration 154.31 9.72 1932 402961 246255 79093240
Chromaturia 153.10 9.72 377 404516 25369 79314126
Labelled drug-drug interaction medication error 149.96 9.72 391 404502 27259 79312236
Psoriatic arthropathy 149.11 9.72 107 404786 77892 79261603
Wound 145.32 9.72 228 404665 115951 79223544
Bradycardia 142.00 9.72 1175 403718 134382 79205113
Confusional state 140.95 9.72 2333 402560 315664 79023831
Neutropenia 140.36 9.72 870 404023 286840 79052655
Chest pain 139.40 9.72 2109 402784 280195 79059300
Pericarditis 138.69 9.72 196 404697 104040 79235455
Irritable bowel syndrome 131.79 9.72 76 404817 62165 79277330
Lip swelling 131.54 9.72 482 404411 40429 79299066
Completed suicide 127.35 9.72 729 404164 245038 79094457
Drug resistance 123.43 9.72 31 404862 42182 79297313
Fibromyalgia 123.33 9.72 88 404805 64252 79275243
Cardiospasm 123.25 9.72 115 404778 3186 79336309
Nightmare 122.55 9.72 348 404545 25513 79313982
Sleep terror 121.65 9.72 131 404762 4327 79335168
Carotid artery occlusion 118.41 9.72 169 404724 7478 79332017
Amnesia 118.08 9.72 632 404261 62425 79277070
Malignant neoplasm progression 117 9.72 330 404563 135660 79203835
Muscle atrophy 116.91 9.72 207 404686 11025 79328470
Blood glucose increased 115.83 9.72 988 403905 113987 79225508
Myocardial ischaemia 115.71 9.72 338 404555 25181 79314314
Palmoplantar keratoderma 113.55 9.72 116 404777 3600 79335895
Muscle rupture 111.46 9.72 115 404778 3612 79335883
Pain 109.34 9.72 2730 402163 701072 78638423
Muscle injury 109.09 9.72 55 404838 48506 79290989
Circulatory collapse 107.28 9.72 427 404466 37241 79302254
Abdominal discomfort 106.87 9.72 789 404104 249938 79089557
Hepatic enzyme increased 106.08 9.72 521 404372 182089 79157406
Haematuria 106.04 9.72 655 404238 68181 79271314
Pruritus genital 105.54 9.72 122 404771 4364 79335131
Cytomegalovirus infection 104.05 9.72 43 404850 42601 79296894
Device expulsion 103.80 9.72 7 404886 25854 79313641
Muscle spasms 103.78 9.72 1349 403544 173381 79166114
Cardiovascular disorder 103.03 9.72 260 404633 17765 79321730
Weight increased 101.69 9.72 909 403984 276477 79063018
Subarachnoid haemorrhage 101.45 9.72 314 404579 24151 79315344
Injection site pain 101.01 9.72 330 404563 129508 79209987
Rash 100.18 9.72 2206 402687 576152 78763343
Dyspnoea 100.13 9.72 5312 399581 851713 78487782
Coronary artery stenosis 99.03 9.72 205 404688 12279 79327216
Ill-defined disorder 98.91 9.72 113 404780 65762 79273733
Gait disturbance 98.82 9.72 1541 403352 205965 79133530
Abortion spontaneous 98.05 9.72 16 404877 29491 79310004
Blood creatinine increased 97.98 9.72 1211 403682 153846 79185649
Angina unstable 97.20 9.72 241 404652 16286 79323209
Arteriosclerosis coronary artery 96.67 9.72 252 404641 17564 79321931
Musculoskeletal stiffness 96.16 9.72 509 404384 174499 79164996
Haematemesis 95.94 9.72 521 404372 51743 79287752
Myelosuppression 94.56 9.72 43 404850 40253 79299242
Self esteem decreased 93.14 9.72 60 404833 942 79338553
Drug ineffective for unapproved indication 91.91 9.72 75 404818 51163 79288332
Renal impairment 90.70 9.72 1211 403682 156572 79182923
Necrotising myositis 89.43 9.72 64 404829 1204 79338291
Cerebral haemorrhage 88.96 9.72 549 404344 57124 79282371
Melaena 88.57 9.72 571 404322 60319 79279176
Tension headache 88.46 9.72 143 404750 7068 79332427
Idiopathic pulmonary fibrosis 87.96 9.72 108 404785 4120 79335375
Haematochezia 87.66 9.72 752 404141 86893 79252602
Gastrointestinal disorder 86.72 9.72 323 404570 121882 79217613
Arthralgia 86.28 9.72 2227 402666 569576 78769919
Pregnancy 86.07 9.72 16 404877 26835 79312660
Lethargy 85.82 9.72 706 404187 80586 79258909
Coronary artery occlusion 82.46 9.72 216 404677 15099 79324396
Immunisation 81.89 9.72 76 404817 2091 79337404
Atrial tachycardia 81.50 9.72 137 404756 6996 79332499
Inappropriate schedule of product administration 81.25 9.72 375 404518 133253 79206242
Hip arthroplasty 81.07 9.72 40 404853 35716 79303779
Myoglobinuria 81.00 9.72 57 404836 1043 79338452
Anosmia 79.48 9.72 153 404740 8691 79330804
Erectile dysfunction 79.14 9.72 207 404686 14457 79325038
Appendicolith 78.16 9.72 149 404744 8402 79331093
Blister 77.65 9.72 327 404566 119149 79220346
Muscle necrosis 77.17 9.72 62 404831 1396 79338099
Upper gastrointestinal haemorrhage 76.28 9.72 413 404480 40967 79298528
Ischaemic stroke 76.17 9.72 352 404541 32779 79306716
Ventricular tachycardia 75.60 9.72 416 404477 41519 79297976
Myoglobin blood increased 74.64 9.72 86 404807 3065 79336430
Therapy non-responder 74.31 9.72 231 404662 92074 79247421
COVID-19 74.14 9.72 482 404411 157192 79182303
Oedema peripheral 73.83 9.72 1739 403154 250549 79088946
Pancreatitis acute 72.65 9.72 466 404427 49138 79290357
Product dose omission issue 72.65 9.72 855 404038 246682 79092813
Hospitalisation 72.26 9.72 241 404652 93995 79245500
Polymyositis 72.15 9.72 83 404810 2953 79336542
Asthma 71.94 9.72 397 404496 134698 79204797
Amyotrophic lateral sclerosis 71.20 9.72 65 404828 1750 79337745
Bone erosion 71.14 9.72 5 404888 17842 79321653
Lower respiratory tract infection 70.31 9.72 377 404516 128843 79210652
Blood pressure fluctuation 70.31 9.72 147 404746 66998 79272497
Drug dependence 70.28 9.72 62 404831 40707 79298788
Muscle twitching 69.93 9.72 280 404613 24484 79315011
Haemorrhage intracranial 69.89 9.72 291 404602 25902 79313593
Subdural haematoma 69.35 9.72 330 404563 31104 79308391
Palpitations 69.17 9.72 963 403930 125647 79213848
Mucosal inflammation 69.06 9.72 178 404715 75402 79264093
Abnormal dreams 68.79 9.72 168 404725 11244 79328251
Swollen tongue 68.68 9.72 410 404483 42160 79297335
Pancreatitis necrotising 67.45 9.72 91 404802 3817 79335678
Acute coronary syndrome 67.10 9.72 248 404645 20885 79318610
Haemodialysis 67.00 9.72 224 404669 17944 79321551
Diabetes mellitus inadequate control 66.65 9.72 272 404621 23992 79315503
Ischaemic cardiomyopathy 66.57 9.72 131 404762 7564 79331931
Social problem 65.39 9.72 56 404837 1382 79338113
Balance disorder 64.99 9.72 778 404115 98079 79241416
Sinus bradycardia 64.65 9.72 277 404616 24970 79314525
Hypotension 64.26 9.72 2791 402102 437526 78901969
Intentional overdose 64.02 9.72 298 404595 105662 79233833
Sedation complication 63.60 9.72 4 404889 15665 79323830
Therapy partial responder 63.59 9.72 7 404886 17390 79322105
Graft versus host disease 63.59 9.72 3 404890 15023 79324472
Oxygen saturation decreased 63.49 9.72 389 404504 128658 79210837
Quality of life decreased 63.46 9.72 154 404739 10266 79329229
Chronic obstructive pulmonary disease 62.78 9.72 687 404206 84732 79254763
Death 62.47 9.72 2300 402593 564214 78775281
Bronchopulmonary aspergillosis 62.11 9.72 18 404875 22276 79317219
Illness 60.33 9.72 89 404804 46422 79293073
Subdural haemorrhage 59.83 9.72 108 404785 5840 79333655
Influenza 59.51 9.72 399 404494 129207 79210288
High density lipoprotein decreased 59.41 9.72 94 404799 4561 79334934
Mitral valve incompetence 58.80 9.72 294 404599 28271 79311224
Haemophagocytic lymphohistiocytosis 58.37 9.72 19 404874 21818 79317677
Blood urea increased 57.69 9.72 435 404458 48355 79291140
Transplant rejection 57.36 9.72 14 404879 19423 79320072
Disease progression 57.12 9.72 629 404264 183733 79155762
Septic shock 56.91 9.72 377 404516 122424 79217071
Pneumonia 56.74 9.72 2757 402136 657489 78682006
Pneumocystis jirovecii pneumonia 56.56 9.72 49 404844 32459 79307036
Peripheral swelling 56.02 9.72 997 403896 268620 79070875
Arteriosclerosis 55.46 9.72 211 404682 18016 79321479
Poisoning deliberate 54.71 9.72 14 404879 18814 79320681
Injection site erythema 54.61 9.72 208 404685 77989 79261506
Myopathy toxic 54.55 9.72 45 404848 1053 79338442
Facial pain 54.48 9.72 162 404731 12188 79327307
Live birth 54.35 9.72 14 404879 18730 79320765
Hyperhidrosis 54.15 9.72 1075 403818 150417 79189078
Therapeutic response shortened 54.07 9.72 8 404885 15855 79323640
Knee arthroplasty 53.94 9.72 85 404808 43163 79296332
Grip strength decreased 53.43 9.72 22 404871 21847 79317648
Neutrophil count decreased 52.86 9.72 271 404622 93688 79245807
Haematoma 52.79 9.72 449 404444 51746 79287749
Diplopia 52.51 9.72 320 404573 33146 79306349
Naevus flammeus 52.49 9.72 19 404874 70 79339425
Bone marrow failure 51.75 9.72 114 404779 50993 79288502
Neoplasm progression 51.74 9.72 116 404777 51566 79287929
Actinic keratosis 51.23 9.72 102 404791 5940 79333555
Arthritis 50.60 9.72 358 404535 114522 79224973
Rhinorrhoea 50.17 9.72 207 404686 75867 79263628
Blood loss anaemia 50.15 9.72 183 404710 15315 79324180
Poor venous access 49.93 9.72 15 404878 18134 79321361
Carotid artery stenosis 49.71 9.72 126 404767 8632 79330863
Suicide attempt 49.65 9.72 234 404659 82698 79256797
Lung disorder 49.59 9.72 225 404668 80332 79259163
Injection site reaction 49.30 9.72 130 404763 54655 79284840
Urosepsis 49.21 9.72 265 404628 26230 79313265
Therapeutic response decreased 49.20 9.72 174 404719 66679 79272816
Premature delivery 49.18 9.72 29 404864 23438 79316057
Hyperglycaemia 49.10 9.72 560 404333 69775 79269720
Renal injury 49.09 9.72 193 404700 16734 79322761
Blindness 48.79 9.72 278 404615 28105 79311390
Disturbance in attention 48.76 9.72 432 404461 50369 79289126
Venoocclusive liver disease 47.79 9.72 3 404890 11768 79327727
Agranulocytosis 47.63 9.72 98 404795 44932 79294563
Cytokine release syndrome 47.56 9.72 68 404825 35930 79303565
Blood pressure systolic increased 47.54 9.72 177 404716 66809 79272686
Pancreatitis 47.42 9.72 545 404348 68030 79271465
Drug reaction with eosinophilia and systemic symptoms 47.42 9.72 167 404726 64077 79275418
Loss of consciousness 47.38 9.72 1152 403741 166791 79172704
Pancytopenia 47.25 9.72 576 404317 165169 79174326
Diabetic ketoacidosis 47.19 9.72 316 404577 33806 79305689
Drug hypersensitivity 47.17 9.72 1156 403737 297760 79041735
Pathogen resistance 47.16 9.72 8 404885 14334 79325161
Coma 47.13 9.72 308 404585 100341 79239154
Sedation 46.81 9.72 123 404770 51772 79287723
Mitochondrial myopathy 46.71 9.72 25 404868 272 79339223
Haematotoxicity 46.14 9.72 11 404882 15508 79323987
Caesarean section 45.93 9.72 5 404888 12530 79326965
Accidental exposure to product 45.65 9.72 55 404838 31267 79308228
Faeces pale 45.39 9.72 65 404828 2885 79336610
Pain in extremity 45.27 9.72 2274 402619 362264 78977231
Impaired healing 44.81 9.72 261 404632 87394 79252101
White blood cell count decreased 44.79 9.72 679 404214 187609 79151886
Orthostatic intolerance 44.72 9.72 52 404841 1872 79337623
Therapeutic drug monitoring analysis not performed 44.46 9.72 52 404841 1884 79337611
Aspergillus infection 44.10 9.72 21 404872 19140 79320355
Hyperlipidaemia 43.82 9.72 254 404639 25839 79313656
Duodenal ulcer 43.78 9.72 182 404711 16187 79323308
Injection site bruising 43.57 9.72 89 404804 40913 79298582
Epstein-Barr virus infection 43.30 9.72 10 404883 14406 79325089
Hypertensive crisis 42.91 9.72 214 404679 20556 79318939
Deep vein thrombosis postoperative 42.89 9.72 3 404890 10749 79328746
Headache 42.77 9.72 2803 402090 650969 78688526
Urticaria 41.98 9.72 674 404219 184527 79154968
Ventricular fibrillation 41.97 9.72 292 404601 31634 79307861
Blood urea abnormal 41.60 9.72 42 404851 1285 79338210
Cutaneous T-cell dyscrasia 41.49 9.72 15 404878 55 79339440
Presyncope 41.43 9.72 353 404540 40701 79298794
Hallucination 41.23 9.72 638 404255 85107 79254388
Fear 40.90 9.72 220 404673 21766 79317729
Contraindicated product prescribed 40.82 9.72 47 404846 1674 79337821
Sleep disorder due to a general medical condition 40.75 9.72 11 404882 14266 79325229
Anaemia 40.63 9.72 2700 402193 442315 78897180
Dermatomyositis 40.62 9.72 69 404824 3554 79335941
Tumour lysis syndrome 40.55 9.72 37 404856 23902 79315593
C-reactive protein increased 40.44 9.72 439 404454 128588 79210907
Urogenital haemorrhage 40.31 9.72 36 404857 941 79338554
Loss of personal independence in daily activities 40.29 9.72 330 404563 102250 79237245
Pain of skin 40.28 9.72 164 404729 14449 79325046
Body temperature decreased 40.25 9.72 63 404830 32082 79307413
Blood glucose fluctuation 39.89 9.72 98 404795 6584 79332911
Wheezing 39.82 9.72 389 404504 116275 79223220
Inflammation 38.96 9.72 297 404596 93456 79246039
Arrhythmia 38.86 9.72 479 404414 60793 79278702
Device difficult to use 38.80 9.72 10 404883 13375 79326120
Psychiatric symptom 38.67 9.72 100 404793 6935 79332560
Diverticulum 38.58 9.72 164 404729 14732 79324763
Breast cancer stage III 38.46 9.72 3 404890 9823 79329672
Lower gastrointestinal haemorrhage 38.31 9.72 173 404720 15952 79323543
Atrioventricular block 38.25 9.72 157 404736 13884 79325611
Thrombotic microangiopathy 38.10 9.72 28 404865 20141 79319354
Abnormal loss of weight 38.02 9.72 111 404782 8265 79331230
Gouty tophus 37.98 9.72 25 404868 408 79339087
Facet joint syndrome 37.84 9.72 6 404887 11296 79328199
Ankylosing spondylitis 37.60 9.72 8 404885 12197 79327298
Cardiogenic shock 37.47 9.72 351 404542 41563 79297932
Intermittent claudication 37.46 9.72 65 404828 3406 79336089
Glycogen storage disease type V 37.45 9.72 12 404881 27 79339468
Joint range of motion decreased 37.31 9.72 70 404823 33212 79306283
Quadriparesis 37.05 9.72 65 404828 3436 79336059
Peripheral vascular disorder 37.02 9.72 107 404786 7923 79331572
Respiratory tract haemorrhage 37.01 9.72 46 404847 1777 79337718
Injection site pruritus 36.79 9.72 102 404791 42181 79297314
Musculoskeletal toxicity 36.79 9.72 19 404874 191 79339304
Oedema mouth 36.74 9.72 60 404833 2991 79336504
Adrenal insufficiency 36.47 9.72 55 404838 28432 79311063
Electrocardiogram abnormal 36.41 9.72 175 404718 16562 79322933
Hemiparesis 36.14 9.72 294 404599 33439 79306056
Pallor 36.03 9.72 401 404492 49661 79289834
Therapy interrupted 35.94 9.72 65 404828 31276 79308219
Ventricular extrasystoles 35.87 9.72 196 404697 19508 79319987
Atrioventricular block complete 35.64 9.72 173 404720 16437 79323058
Atrioventricular block first degree 35.08 9.72 141 404752 12350 79327145
Device issue 35.03 9.72 52 404841 27056 79312439
Labile hypertension 34.85 9.72 26 404867 523 79338972
Tinnitus 34.64 9.72 361 404532 43972 79295523
Coronary artery thrombosis 34.62 9.72 59 404834 3047 79336448
Osteoporosis 34.59 9.72 149 404744 53963 79285532
Transient global amnesia 34.55 9.72 33 404860 942 79338553
Cytomegalovirus viraemia 34.54 9.72 11 404882 12810 79326685
Dialysis 34.52 9.72 185 404708 18277 79321218
Glomerular filtration rate decreased 34.31 9.72 215 404678 22487 79317008
Peripheral venous disease 34.28 9.72 19 404874 15890 79323605
Peripheral arterial occlusive disease 34.25 9.72 106 404787 8152 79331343
Bacteraemia 34.24 9.72 72 404821 32752 79306743
Mucosal haemorrhage 34.09 9.72 53 404840 2533 79336962
Blood potassium increased 34.04 9.72 260 404633 29015 79310480
Systemic infection 33.99 9.72 118 404775 9634 79329861
Sinus node dysfunction 33.95 9.72 101 404792 7600 79331895
Cytopenia 33.94 9.72 32 404861 20351 79319144
Anuria 33.87 9.72 202 404691 20761 79318734
Faeces discoloured 33.48 9.72 258 404635 28869 79310626
Cardiac disorder 33.44 9.72 494 404399 65263 79274232
Muscle disorder 33.33 9.72 83 404810 5624 79333871
Herpes zoster 33.20 9.72 307 404586 92776 79246719
Gynaecomastia 33.17 9.72 100 404793 7581 79331914
Decorticate posture 33.08 9.72 21 404872 321 79339174
Blood glucose decreased 32.78 9.72 237 404656 25997 79313498
Nocturia 32.67 9.72 147 404746 13534 79325961
Orthostatic hypotension 32.63 9.72 432 404461 55732 79283763
Blood pressure systolic abnormal 32.51 9.72 24 404869 17223 79322272
Multiple injuries 32.07 9.72 61 404832 3434 79336061
Glycosylated haemoglobin increased 32.03 9.72 187 404706 19073 79320422
Upper respiratory tract infection 31.95 9.72 302 404591 90866 79248629
Ear pain 31.91 9.72 75 404818 32794 79306701
Pemphigoid 31.79 9.72 158 404735 15157 79324338
Collagen disorder 31.75 9.72 19 404874 260 79339235
Thrombocytopenia 31.65 9.72 1066 403827 264193 79075302
Acne 31.53 9.72 56 404837 27134 79312361
Appendicitis 31.47 9.72 197 404696 20597 79318898
Lichenoid keratosis 31.45 9.72 66 404827 3991 79335504
Myocardial depression 31.25 9.72 24 404869 505 79338990
Blood pressure inadequately controlled 31.11 9.72 85 404808 6092 79333403
Potentiating drug interaction 30.99 9.72 107 404786 8712 79330783
Immunodeficiency 30.91 9.72 39 404854 21729 79317766
Jaundice 30.85 9.72 410 404483 52939 79286556
Compartment syndrome 30.83 9.72 75 404818 5007 79334488
Infusion site pain 30.45 9.72 17 404876 14159 79325336
Hyperthermia 30.41 9.72 28 404865 18009 79321486
Substance abuse 30.25 9.72 8 404885 10518 79328977
Social avoidant behaviour 30.23 9.72 72 404821 4742 79334753
Pseudomonas infection 30.15 9.72 37 404856 20866 79318629
Heavy menstrual bleeding 29.81 9.72 17 404876 13994 79325501
Low density lipoprotein increased 29.77 9.72 104 404789 8518 79330977
Disease recurrence 29.72 9.72 119 404774 43990 79295505
Haemorrhagic stroke 29.69 9.72 123 404770 10923 79328572
Prostate cancer recurrent 29.59 9.72 28 404865 790 79338705
Aortic arteriosclerosis 29.45 9.72 106 404787 8812 79330683
Hypophagia 29.35 9.72 356 404537 45011 79294484
Gastritis erosive 29.32 9.72 121 404772 10726 79328769
Autoimmune hepatitis 29.19 9.72 128 404765 11655 79327840
Lymphocyte count decreased 29.15 9.72 132 404761 47157 79292338
Rash papular 29.14 9.72 201 404692 21715 79317780
Productive cough 29.11 9.72 297 404596 88034 79251461
Dysarthria 29.09 9.72 494 404399 67128 79272367
Head injury 29.06 9.72 304 404589 37065 79302430
Hepatic cyst 28.91 9.72 82 404811 6007 79333488
Febrile bone marrow aplasia 28.86 9.72 15 404878 13005 79326490
Injection site swelling 28.79 9.72 132 404761 47000 79292495
Vasculitis 28.66 9.72 222 404671 24880 79314615
Hypokalaemia 28.60 9.72 945 403948 143095 79196400
Actinic elastosis 28.58 9.72 11 404882 50 79339445
Ear infection 28.54 9.72 85 404808 34347 79305148
Intraventricular haemorrhage 28.46 9.72 71 404822 4816 79334679
Wrong technique in product usage process 28.40 9.72 239 404654 73636 79265859
Pancreatic steatosis 28.39 9.72 32 404861 1113 79338382
Gout 28.32 9.72 219 404674 24530 79314965
Myasthenia gravis 28.11 9.72 116 404777 10283 79329212
Obstructive airways disorder 28.04 9.72 75 404818 31384 79308111
Oral herpes 27.99 9.72 61 404832 27393 79312102
Platelet count decreased 27.97 9.72 763 404130 193901 79145594
Blood pressure diastolic abnormal 27.68 9.72 34 404859 19168 79320327
Migraine 27.68 9.72 297 404596 87196 79252299
Lower limb fracture 27.66 9.72 47 404846 23168 79316327
Cold sweat 27.58 9.72 176 404717 18523 79320972
Foetal death 27.55 9.72 4 404889 8040 79331455
Spinal cord haemorrhage 27.43 9.72 23 404870 551 79338944
Dilatation atrial 27.27 9.72 59 404834 3645 79335850
Ubiquinone decreased 27.02 9.72 9 404884 24 79339471
International normalised ratio abnormal 26.72 9.72 77 404816 5691 79333804
International normalised ratio decreased 26.71 9.72 96 404797 7974 79331521
Cardiac failure 26.56 9.72 999 403894 153843 79185652
Blood pressure diastolic increased 26.44 9.72 21 404872 14521 79324974
Carotid arteriosclerosis 26.43 9.72 48 404845 2608 79336887
Immune reconstitution inflammatory syndrome 26.43 9.72 19 404874 13822 79325673
Unresponsive to stimuli 26.40 9.72 414 404479 55374 79284121
Tenosynovitis 26.39 9.72 24 404869 15530 79323965
Exposure to toxic agent 26.25 9.72 7 404886 9151 79330344
Blood phosphorus increased 26.09 9.72 113 404780 10234 79329261
Adjustment disorder with depressed mood 25.94 9.72 7 404886 9079 79330416
Liver function test increased 25.74 9.72 109 404784 39664 79299831
Duodenitis 25.72 9.72 94 404799 7873 79331622
Blood creatine phosphokinase MB increased 25.72 9.72 49 404844 2762 79336733
Angioplasty 25.71 9.72 39 404854 1824 79337671
Anhedonia 25.66 9.72 146 404747 14752 79324743
Prescribed overdose 25.66 9.72 102 404791 37781 79301714
Night sweats 25.63 9.72 157 404736 51938 79287557
Posterior reversible encephalopathy syndrome 25.49 9.72 60 404833 26221 79313274
Rectal haemorrhage 25.45 9.72 536 404357 75764 79263731
Oropharyngeal pain 25.43 9.72 396 404497 108957 79230538
Haemarthrosis 25.41 9.72 76 404817 5736 79333759
Swelling face 25.32 9.72 505 404388 70707 79268788
Femoral hernia incarcerated 25.21 9.72 26 404867 816 79338679
Retinal artery thrombosis 25.16 9.72 12 404881 100 79339395
Tuberculosis 25.14 9.72 24 404869 15174 79324321
Ischaemia 25.00 9.72 94 404799 7981 79331514
Aphasia 24.92 9.72 354 404539 46378 79293117
Upper motor neurone lesion 24.90 9.72 16 404877 250 79339245
Blood glucose abnormal 24.83 9.72 113 404780 10453 79329042
Postprandial hypoglycaemia 24.81 9.72 11 404882 76 79339419
Ejaculation failure 24.78 9.72 18 404875 347 79339148
Sprue-like enteropathy 24.77 9.72 32 404861 1286 79338209
Lip dry 24.75 9.72 25 404868 15393 79324102
BK virus infection 24.72 9.72 7 404886 8797 79330698
Laryngitis 24.63 9.72 27 404866 16012 79323483
Colitis microscopic 24.45 9.72 114 404779 10654 79328841
Autoimmune disorder 24.39 9.72 29 404864 16583 79322912
Cytomegalovirus infection reactivation 24.35 9.72 7 404886 8709 79330786
Lymphopenia 24.21 9.72 77 404816 30480 79309015
Spontaneous haemorrhage 24.05 9.72 25 404868 792 79338703
Red blood cell sedimentation rate increased 23.90 9.72 136 404757 45806 79293689
Portal fibrosis 23.89 9.72 22 404871 599 79338896
Wound infection 23.89 9.72 54 404839 23937 79315558
Breast cancer stage II 23.67 9.72 6 404887 8114 79331381
Hepatic function abnormal 23.60 9.72 247 404646 72860 79266635
Myoglobin urine 23.59 9.72 8 404885 23 79339472
Hallucination, visual 23.47 9.72 262 404631 32467 79307028
Enthesopathy 23.41 9.72 15 404878 11593 79327902
Urinary retention 23.38 9.72 411 404482 56219 79283276
Hypomagnesaemia 23.30 9.72 351 404542 46560 79292935
Granuloma annulare 23.21 9.72 22 404871 622 79338873
Device dislocation 23.08 9.72 62 404831 25908 79313587
Respiratory depression 23.05 9.72 68 404825 27562 79311933
Facial paresis 22.98 9.72 71 404822 5455 79334040
Cerebrospinal fluid retention 22.93 9.72 11 404882 93 79339402
Cognitive disorder 22.93 9.72 490 404403 69436 79270059
Hyperammonaemia 22.84 9.72 14 404879 11079 79328416
Fear of injection 22.82 9.72 5 404888 7469 79332026
Aortic valve sclerosis 22.80 9.72 36 404857 1744 79337751
Cystitis haemorrhagic 22.78 9.72 9 404884 9163 79330332
Visual impairment 22.76 9.72 621 404272 91510 79247985
Nasal congestion 22.58 9.72 264 404629 76288 79263207
Post procedural haemorrhage 22.57 9.72 133 404760 13611 79325884
Electrolyte imbalance 22.51 9.72 248 404645 30633 79308862
Cerebral artery thrombosis 22.50 9.72 28 404865 1083 79338412
Neurotoxicity 22.38 9.72 87 404806 32431 79307064
Drug use disorder 22.30 9.72 8 404885 8643 79330852
Seroma 22.17 9.72 41 404852 2259 79337236
Intentional self-injury 22.14 9.72 87 404806 32332 79307163
Heart rate decreased 22.12 9.72 239 404654 70077 79269418
Complication of device insertion 22.12 9.72 3 404890 6347 79333148
Thrombotic thrombocytopenic purpura 22.09 9.72 77 404816 6299 79333196
Alanine aminotransferase increased 22.00 9.72 1023 403870 161547 79177948
Leukopenia 21.96 9.72 438 404455 116075 79223420
Radiation inflammation 21.94 9.72 25 404868 880 79338615
Pneumonia fungal 21.92 9.72 15 404878 11195 79328300
Brain scan abnormal 21.91 9.72 29 404864 1194 79338301
Abdominal pain lower 21.70 9.72 252 404641 31530 79307965
Transplant dysfunction 21.70 9.72 5 404888 7216 79332279
Scrotal oedema 21.62 9.72 33 404860 1552 79337943
Candida infection 21.61 9.72 110 404783 38104 79301391
Avoidant personality disorder 21.60 9.72 6 404887 6 79339489
Spermatozoa abnormal 21.60 9.72 6 404887 6 79339489
Occupational problem environmental 21.60 9.72 6 404887 6 79339489
Lacunar infarction 21.57 9.72 73 404820 5884 79333611
Cerebral ischaemia 21.49 9.72 113 404780 11082 79328413
Exercise tolerance decreased 21.31 9.72 97 404796 8974 79330521
SARS-CoV-2 test positive 21.20 9.72 17 404876 11699 79327796
Malignant spinal cord compression 21.20 9.72 12 404881 147 79339348
Chronic kidney disease 21.19 9.72 462 404431 65692 79273803
Coeliac disease 21.13 9.72 16 404877 11335 79328160
Gait inability 21.01 9.72 418 404475 58499 79280996
Sickle cell anaemia with crisis 20.99 9.72 7 404886 7915 79331580
Post viral fatigue syndrome 20.98 9.72 16 404877 333 79339162
Cerebral arteriosclerosis 20.96 9.72 23 404870 776 79338719
Periarthritis calcarea 20.80 9.72 10 404883 85 79339410
Tachyarrhythmia 20.69 9.72 80 404813 6882 79332613
Respiratory disorder 20.62 9.72 138 404755 44718 79294777
Emotional distress 20.61 9.72 301 404592 39668 79299827
Erythema dyschromicum perstans 20.57 9.72 9 404884 60 79339435
Forced expiratory volume decreased 20.53 9.72 7 404886 7807 79331688
Oesophagitis 20.52 9.72 201 404692 24088 79315407
Dysuria 20.40 9.72 368 404525 50583 79288912
Respiratory tract infection 20.34 9.72 154 404739 48535 79290960
Eye pruritus 20.29 9.72 176 404717 20394 79319101
Apolipoprotein A-I decreased 20.18 9.72 7 404886 22 79339473
Platelet count normal 20.18 9.72 7 404886 22 79339473
Uveitis 20.12 9.72 34 404859 16796 79322699
Disability 20.09 9.72 35 404858 17085 79322410
Dermatitis exfoliative 19.90 9.72 108 404785 10721 79328774
Dystonia 19.85 9.72 50 404843 21349 79318146
Linear IgA disease 19.84 9.72 47 404846 3085 79336410
Sudden cardiac death 19.78 9.72 65 404828 5160 79334335
Atrial flutter 19.78 9.72 182 404711 21443 79318052
Ovarian cyst 19.77 9.72 21 404872 12634 79326861
Osteochondrosis 19.77 9.72 36 404857 1960 79337535
Vascular stent stenosis 19.72 9.72 31 404862 1496 79337999
Uterine perforation 19.69 9.72 4 404889 6299 79333196
Cerebrovascular disorder 19.69 9.72 52 404841 3653 79335842
Biliary cirrhosis 19.63 9.72 12 404881 171 79339324
Respiratory arrest 19.59 9.72 192 404701 57358 79282137
Ocular myasthenia 19.52 9.72 16 404877 371 79339124
Systemic candida 19.46 9.72 5 404888 6701 79332794
Breast cancer stage I 19.43 9.72 5 404888 6695 79332800
Rhinovirus infection 19.43 9.72 8 404885 7945 79331550
Oesophageal obstruction 19.42 9.72 25 404868 1001 79338494
Gastritis 19.35 9.72 347 404546 47646 79291849
Speech disorder 19.32 9.72 386 404507 54059 79285436
Duodenal ulcer repair 19.29 9.72 9 404884 71 79339424
Ventricular hypertrophy 19.23 9.72 78 404815 6860 79332635
Drug level decreased 19.23 9.72 27 404866 14375 79325120
Drug specific antibody present 19.22 9.72 5 404888 6647 79332848
Food allergy 19.22 9.72 16 404877 10808 79328687
Lymphatic fistula 19.16 9.72 22 404871 781 79338714
Subacute hepatic failure 19.14 9.72 13 404880 224 79339271
Therapy cessation 19.11 9.72 112 404781 37450 79302045
Tricuspid valve incompetence 19.11 9.72 168 404725 19544 79319951
Pulmonary tuberculosis 19.07 9.72 8 404885 7857 79331638
Injection site rash 19.05 9.72 39 404854 17915 79321580
Neuropathy, ataxia, retinitis pigmentosa syndrome 18.98 9.72 8 404885 48 79339447
Diabetic neuropathy 18.95 9.72 72 404821 6144 79333351
Ageusia 18.94 9.72 147 404746 16485 79323010
Tongue oedema 18.93 9.72 79 404814 7038 79332457
No adverse event 18.87 9.72 111 404782 37081 79302414
Sodium retention 18.82 9.72 12 404881 185 79339310
Product dose omission in error 18.76 9.72 8 404885 7780 79331715
Extrasystoles 18.69 9.72 81 404812 7338 79332157
Cardio-respiratory arrest 18.66 9.72 414 404479 108096 79231399
Bundle branch block left 18.64 9.72 111 404782 11402 79328093
Femoral neck fracture 18.64 9.72 100 404793 9884 79329611
Enterocolitis 18.59 9.72 28 404865 14484 79325011
Hyperbilirubinaemia 18.59 9.72 63 404830 24455 79315040
Carcinogenicity 18.57 9.72 9 404884 78 79339417
Ketoacidosis 18.46 9.72 84 404809 7770 79331725
Spinal osteoarthritis 18.39 9.72 148 404745 16779 79322716
Incorrect route of product administration 18.39 9.72 103 404790 34826 79304669
Blood test abnormal 18.34 9.72 39 404854 17671 79321824
Hiatus hernia 18.29 9.72 190 404703 23122 79316373
Erosive duodenitis 18.26 9.72 36 404857 2081 79337414
Cerebral artery occlusion 18.26 9.72 32 404861 1690 79337805
Pulmonary fibrosis 18.16 9.72 320 404573 43792 79295703
Sensory disturbance 18.14 9.72 135 404758 14942 79324553
Pneumatosis intestinalis 18.13 9.72 5 404888 6392 79333103
Cytomegalovirus test positive 18.11 9.72 4 404889 5943 79333552
Helicobacter gastritis 18.02 9.72 39 404854 2410 79337085
Urinary incontinence 18.01 9.72 300 404593 40609 79298886
Memory impairment 18.00 9.72 716 404177 111018 79228477
Complications of transplanted kidney 17.99 9.72 5 404888 6361 79333134
Dyspnoea exertional 17.99 9.72 574 404319 86499 79252996
Viral myositis 17.83 9.72 8 404885 57 79339438
Mitochondrial myopathy acquired 17.82 9.72 7 404886 34 79339461
Nodular rash 17.74 9.72 14 404879 307 79339188
Normochromic normocytic anaemia 17.69 9.72 82 404811 7645 79331850
Altered state of consciousness 17.65 9.72 140 404753 43682 79295813
Polyneuropathy 17.63 9.72 194 404699 23957 79315538
Malnutrition 17.62 9.72 57 404836 22445 79317050
Liver disorder 17.60 9.72 260 404633 72157 79267338
Hypogammaglobulinaemia 17.57 9.72 24 404869 12927 79326568
Akathisia 17.56 9.72 25 404868 13234 79326261
Left ventricular hypertrophy 17.55 9.72 107 404786 11084 79328411
Blood cholesterol increased 17.55 9.72 309 404584 83411 79256084
Genital haemorrhage 17.52 9.72 5 404888 6250 79333245
Leukocyturia 17.45 9.72 34 404859 1949 79337546
Genital swelling 17.40 9.72 14 404879 316 79339179
Gastric ulcer 17.35 9.72 255 404638 33650 79305845
Pleurothotonus 17.30 9.72 39 404854 2477 79337018
Dysphagia 17.27 9.72 772 404121 121364 79218131
Myxoedema coma 17.26 9.72 20 404873 717 79338778
Bronchitis 17.26 9.72 518 404375 130126 79209369
Left ventricular failure 17.23 9.72 95 404798 9486 79330009
Hypothermia 17.19 9.72 184 404709 22562 79316933
Pseudomonal sepsis 17.17 9.72 5 404888 6169 79333326
Poisoning 17.14 9.72 68 404825 25204 79314291
Acquired claw toe 17.13 9.72 9 404884 94 79339401
Cerebral ventricular rupture 17.13 9.72 16 404877 444 79339051
Intestinal obstruction 17.07 9.72 138 404755 42882 79296613
Device malfunction 17.03 9.72 54 404839 21394 79318101
Sleep attacks 17.01 9.72 11 404882 174 79339321
Cerebellar ataxia 16.98 9.72 33 404860 1888 79337607
Blood sodium decreased 16.97 9.72 250 404643 33005 79306490
Hypoglycaemic coma 16.94 9.72 58 404835 4702 79334793
Anal fistula 16.94 9.72 7 404886 6937 79332558
Biopsy muscle abnormal 16.89 9.72 7 404886 40 79339455
Amenorrhoea 16.85 9.72 9 404884 7683 79331812
Polymyalgia rheumatica 16.78 9.72 56 404837 4481 79335014
Alveolitis 16.73 9.72 53 404840 4127 79335368
Coronary artery bypass 16.68 9.72 68 404825 5994 79333501
Hepatitis cholestatic 16.65 9.72 124 404769 13728 79325767
Blood pressure increased 16.65 9.72 890 404003 210470 79129025
Contracted bladder 16.60 9.72 6 404887 22 79339473
Mydriasis 16.54 9.72 41 404852 17602 79321893
Brain oedema 16.49 9.72 69 404824 25194 79314301
Prothrombin time abnormal 16.48 9.72 24 404869 1082 79338413
Electromyogram abnormal 16.45 9.72 10 404883 141 79339354
Torsade de pointes 16.40 9.72 160 404733 19152 79320343
Product administered to patient of inappropriate age 16.38 9.72 4 404889 5549 79333946
Atrioventricular block second degree 16.30 9.72 77 404816 7235 79332260
Cardiotoxicity 16.28 9.72 23 404870 12216 79327279
Hepatitis C 16.28 9.72 22 404871 11903 79327592
Adverse drug reaction 16.26 9.72 238 404655 66154 79273341
Groin pain 16.24 9.72 118 404775 12962 79326533
Epistaxis 16.24 9.72 707 404186 110808 79228687
Arteriosclerotic gangrene 16.16 9.72 8 404885 73 79339422
Adverse event 16.12 9.72 212 404681 60002 79279493
Joint destruction 16.11 9.72 5 404888 5920 79333575
Cytomegalovirus chorioretinitis 16.11 9.72 4 404889 5486 79334009
Lid lag 16.06 9.72 8 404885 74 79339421
Aortic aneurysm 16.04 9.72 85 404808 8361 79331134
Joint effusion 16.01 9.72 43 404850 17971 79321524
Respiratory tract congestion 16.01 9.72 50 404843 19904 79319591
Metabolic acidosis 16.01 9.72 540 404353 81989 79257506
Areflexia 15.97 9.72 63 404830 5471 79334024
Pharyngitis 15.95 9.72 59 404834 22316 79317179
Supraventricular extrasystoles 15.88 9.72 74 404819 6913 79332582
Spontaneous haematoma 15.83 9.72 27 404866 1395 79338100
Temperature regulation disorder 15.81 9.72 5 404888 5848 79333647
Product complaint 15.77 9.72 119 404774 13230 79326265
Long QT syndrome 15.76 9.72 66 404827 5889 79333606
Mobility decreased 15.75 9.72 486 404407 121689 79217806
Muscle spasticity 15.73 9.72 56 404837 21419 79318076
Encephalopathy 15.69 9.72 244 404649 67153 79272342
X-ray abnormal 15.64 9.72 5 404888 5808 79333687
Blood electrolytes abnormal 15.62 9.72 32 404861 1902 79337593
Disseminated intravascular coagulation 15.62 9.72 112 404781 35730 79303765
Clostridium difficile infection 15.56 9.72 140 404753 42545 79296950
White blood cell count increased 15.42 9.72 492 404401 74141 79265354
Pharyngitis streptococcal 15.41 9.72 19 404874 10695 79328800
Respiratory syncytial virus infection 15.37 9.72 15 404878 9387 79330108
Second primary malignancy 15.37 9.72 31 404862 14319 79325176
Abdominal distension 15.35 9.72 749 404144 118901 79220594
Blood triglycerides increased 15.35 9.72 169 404724 20871 79318624
Gastric disorder 15.35 9.72 119 404774 37314 79302181
Prothrombin time prolonged 15.34 9.72 142 404751 16757 79322738
Aortic stenosis 15.32 9.72 77 404816 7418 79332077
Adrenal cyst 15.31 9.72 10 404883 161 79339334
Paralysis 15.30 9.72 117 404776 13060 79326435
Hand-eye coordination impaired 15.29 9.72 6 404887 29 79339466
Parakeratosis 15.24 9.72 14 404879 380 79339115
Coronary arterial stent insertion 15.23 9.72 66 404827 5978 79333517
Prostatic specific antigen abnormal 15.21 9.72 15 404878 446 79339049
Blood lactic acid 15.15 9.72 15 404878 448 79339047
Angioimmunoblastic T-cell lymphoma 15.12 9.72 15 404878 449 79339046
Parainfluenzae virus infection 15.09 9.72 5 404888 5677 79333818
Colorectal cancer 15.08 9.72 13 404880 8634 79330861
Nocardiosis 15.08 9.72 5 404888 5674 79333821
Renal cyst 15.03 9.72 127 404766 14605 79324890
Orthopnoea 14.97 9.72 95 404798 9978 79329517
Sciatica 14.88 9.72 103 404790 33119 79306376
Aortic valve incompetence 14.87 9.72 91 404802 9439 79330056
Mitral valve stenosis 14.85 9.72 24 404869 1186 79338309
Bundle branch block right 14.84 9.72 103 404790 11148 79328347
Bladder trabeculation 14.82 9.72 7 404886 57 79339438
Status epilepticus 14.78 9.72 71 404822 24970 79314525
Cushingoid 14.76 9.72 16 404877 9536 79329959
Hypertensive heart disease 14.75 9.72 51 404842 4155 79335340
Coronavirus infection 14.70 9.72 10 404883 7487 79332008
Arterial haemorrhage 14.70 9.72 37 404856 2524 79336971
Coronary angioplasty 14.68 9.72 14 404879 399 79339096
Bladder obstruction 14.64 9.72 15 404878 467 79339028
Full blood count abnormal 14.64 9.72 133 404760 40341 79299154
Diverticulum intestinal 14.60 9.72 84 404809 8521 79330974
Puncture site haematoma 14.59 9.72 10 404883 175 79339320
Aplasia 14.59 9.72 11 404882 7809 79331686
Penile curvature 14.59 9.72 5 404888 15 79339480
Macroenzyme creatine kinase 14.59 9.72 5 404888 15 79339480
Brucellosis 14.56 9.72 9 404884 131 79339364
Pancreatic carcinoma metastatic 14.49 9.72 47 404846 3706 79335789
Diabetic hyperosmolar coma 14.43 9.72 19 404874 778 79338717
Pneumonia bacterial 14.43 9.72 50 404843 19281 79320214
Glycogen storage disease type II 14.40 9.72 4 404889 4 79339491
Embolic stroke 14.35 9.72 78 404815 7748 79331747
Nodule 14.28 9.72 64 404829 22930 79316565
Device breakage 14.26 9.72 20 404873 10655 79328840
Degenerative aortic valve disease 14.26 9.72 10 404883 182 79339313
Exercise lack of 14.24 9.72 15 404878 483 79339012
Duodenal ulcer haemorrhage 14.23 9.72 73 404820 7090 79332405
Palmar-plantar erythrodysaesthesia syndrome 14.22 9.72 104 404789 33030 79306465
Endocrine ophthalmopathy 14.19 9.72 18 404875 710 79338785
Vertebral artery stenosis 14.16 9.72 10 404883 184 79339311
AST/ALT ratio abnormal 14.12 9.72 5 404888 17 79339478
Blepharospasm 14.11 9.72 6 404887 5845 79333650
Crystal nephropathy 14.10 9.72 26 404867 1429 79338066
Venoocclusive disease 14.08 9.72 3 404890 4570 79334925
Frequent bowel movements 14.02 9.72 90 404803 29449 79310046
Drug tolerance 14.00 9.72 14 404879 8661 79330834
Metastases to bone 13.99 9.72 70 404823 24357 79315138
Subdural hygroma 13.96 9.72 15 404878 494 79339001
Ureteric injury 13.93 9.72 9 404884 142 79339353
Multiple sclerosis relapse 13.91 9.72 160 404733 46373 79293122
Catheter site pain 13.89 9.72 5 404888 5391 79334104
Parkinsonism 13.89 9.72 137 404756 16447 79323048
Hypoglycaemic unconsciousness 13.89 9.72 23 404870 1160 79338335
Hypovolaemia 13.79 9.72 144 404749 17547 79321948
Lipase increased 13.78 9.72 136 404757 16330 79323165
Lumbar radiculopathy 13.76 9.72 31 404862 1968 79337527
Blood urine 13.76 9.72 20 404873 900 79338595
Shock hypoglycaemic 13.76 9.72 11 404882 246 79339249
Urine output decreased 13.72 9.72 146 404747 17876 79321619
Cerebral infarction 13.69 9.72 316 404577 45360 79294135
Hepatitis B reactivation 13.59 9.72 7 404886 6101 79333394
Job dissatisfaction 13.59 9.72 7 404886 70 79339425
Polyuria 13.55 9.72 126 404767 14888 79324607
Colitis ulcerative 13.53 9.72 112 404781 34630 79304865
Diverticulum intestinal haemorrhagic 13.52 9.72 48 404845 3963 79335532
Aortic valve stenosis 13.49 9.72 58 404835 5236 79334259
Ventricular hypokinesia 13.48 9.72 87 404806 9192 79330303
Osteoma 13.46 9.72 8 404885 108 79339387
Antipsychotic drug level decreased 13.31 9.72 23 404870 1201 79338294
Interstitial lung disease 13.30 9.72 453 404440 112147 79227348
Secretion discharge 13.25 9.72 36 404857 14986 79324509
Nail disorder 13.22 9.72 25 404868 11827 79327668
Carotid bruit 13.16 9.72 18 404875 765 79338730
Carcinoma in situ 13.15 9.72 8 404885 113 79339382
Lichen myxoedematosus 13.12 9.72 6 404887 45 79339450
Rheumatoid nodule 13.09 9.72 45 404848 17393 79322102
Epiglottic oedema 13.05 9.72 12 404881 326 79339169
Non-cardiac chest pain 13.05 9.72 88 404805 9436 79330059
Vasculitic rash 13.00 9.72 32 404861 2152 79337343
Wound dehiscence 12.96 9.72 67 404826 6528 79332967
Injected limb mobility decreased 12.94 9.72 5 404888 23 79339472
Acetonaemia 12.93 9.72 12 404881 330 79339165
Intestinal angioedema 12.92 9.72 19 404874 864 79338631
Loose tooth 12.92 9.72 40 404853 3077 79336418
Bronchiectasis 12.91 9.72 64 404829 22322 79317173
Klebsiella infection 12.89 9.72 39 404854 15681 79323814
Auricular swelling 12.87 9.72 9 404884 163 79339332
Wrong patient received product 12.87 9.72 52 404841 4566 79334929
Faecal calprotectin increased 12.86 9.72 6 404887 5535 79333960
Fracture blisters 12.86 9.72 7 404886 79 79339416
Neuromyopathy 12.85 9.72 26 404867 1532 79337963
Heart rate increased 12.83 9.72 492 404401 120232 79219263
Intra-abdominal haematoma 12.83 9.72 38 404855 2853 79336642
Polycystic liver disease 12.82 9.72 9 404884 164 79339331
Depressed level of consciousness 12.82 9.72 383 404510 96269 79243226
Hepatitis toxic 12.81 9.72 56 404837 5091 79334404
Carnitine palmitoyltransferase deficiency 12.80 9.72 4 404889 8 79339487
Low turnover osteopathy 12.79 9.72 30 404863 1956 79337539
Pancreatic carcinoma 12.79 9.72 115 404778 13462 79326033
Body temperature increased 12.79 9.72 154 404739 44266 79295229
Eye swelling 12.74 9.72 197 404696 26271 79313224
Arterial occlusive disease 12.72 9.72 80 404813 8376 79331119
Paresis 12.69 9.72 49 404844 4212 79335283
Eye haemorrhage 12.68 9.72 89 404804 9668 79329827
Foot deformity 12.67 9.72 71 404822 24003 79315492
Cytomegalovirus colitis 12.66 9.72 4 404889 4681 79334814
Brain stem infarction 12.64 9.72 30 404863 1971 79337524
Vascular graft occlusion 12.64 9.72 17 404876 711 79338784
Muscle fatigue 12.63 9.72 43 404850 3476 79336019
Muscle discomfort 12.63 9.72 11 404882 278 79339217
Blood pressure difference of extremities 12.61 9.72 5 404888 25 79339470
Extremity necrosis 12.58 9.72 40 404853 3121 79336374
Serum ferritin abnormal 12.56 9.72 13 404880 410 79339085
Cardiac stress test abnormal 12.55 9.72 18 404875 800 79338695
Splenic necrosis 12.54 9.72 9 404884 170 79339325
Lymphadenitis 12.53 9.72 4 404889 4651 79334844
Dental examination abnormal 12.48 9.72 4 404889 9 79339486
Electrolyte depletion 12.48 9.72 13 404880 413 79339082
Conjunctival discolouration 12.45 9.72 8 404885 125 79339370
Skin infection 12.43 9.72 49 404844 18196 79321299
Feeling abnormal 12.43 9.72 954 403939 158245 79181250
Menstruation irregular 12.41 9.72 5 404888 5031 79334464
Food interaction 12.40 9.72 27 404866 1675 79337820
Pollakiuria 12.39 9.72 262 404631 37055 79302440
Hypomania 12.38 9.72 12 404881 7532 79331963
Subacute cutaneous lupus erythematosus 12.34 9.72 43 404850 3518 79335977
Osteonecrosis of external auditory canal 12.32 9.72 9 404884 175 79339320
Infarction 12.30 9.72 51 404842 4531 79334964
Femoral artery embolism 12.28 9.72 6 404887 53 79339442
Carotid artery disease 12.26 9.72 32 404861 2232 79337263
Injection site haemorrhage 12.19 9.72 87 404806 27783 79311712
Wound infection pseudomonas 12.14 9.72 26 404867 1595 79337900
Pneumonia cytomegaloviral 12.14 9.72 5 404888 4964 79334531
Malaise 12.12 9.72 2736 402157 487133 78852362
Neuropathic muscular atrophy 12.09 9.72 6 404887 55 79339440
Nephrolithiasis 12.04 9.72 194 404699 53097 79286398
Neoplasm prostate 12.02 9.72 9 404884 182 79339313
Flatulence 12.01 9.72 293 404600 42431 79297064
Pharyngeal oedema 12.01 9.72 131 404762 16141 79323354
Change of bowel habit 12.00 9.72 36 404857 2721 79336774
Alcohol use disorder 12.00 9.72 5 404888 29 79339466
Poliomyelitis 12 9.72 6 404887 56 79339439
Coronavirus test positive 12.00 9.72 21 404872 1108 79338387
Listless 12.00 9.72 45 404848 3816 79335679
Sinus disorder 11.96 9.72 66 404827 22398 79317097
Hepatocellular carcinoma 11.96 9.72 17 404876 9004 79330491
Blood pressure diastolic decreased 11.95 9.72 97 404796 30119 79309376
Staphylococcal infection 11.95 9.72 216 404677 58079 79281416
Fungal infection 11.92 9.72 145 404748 41603 79297892
Intrapericardial thrombosis 11.91 9.72 6 404887 57 79339438
Orbital swelling 11.91 9.72 6 404887 57 79339438
Aortic valve calcification 11.90 9.72 17 404876 753 79338742
Sinus rhythm 11.89 9.72 18 404875 840 79338655
Prostate cancer metastatic 11.87 9.72 46 404847 3961 79335534
Lordosis 11.86 9.72 13 404880 438 79339057
Sensitivity to weather change 11.86 9.72 14 404879 8033 79331462
Vulvar basal cell carcinoma 11.86 9.72 5 404888 30 79339465
Deformity 11.86 9.72 19 404874 9586 79329909
Liver injury 11.85 9.72 209 404684 56405 79283090
Pancreatic duct stenosis 11.84 9.72 10 404883 242 79339253
Dysgeusia 11.83 9.72 377 404516 56800 79282695
Anaphylactic reaction 11.82 9.72 329 404564 83414 79256081
Osteoarthritis 11.82 9.72 345 404548 86964 79252531
Central nervous system lesion 11.81 9.72 32 404861 13336 79326159
Gilbert's syndrome 11.73 9.72 5 404888 31 79339464
Parotid gland haemorrhage 11.73 9.72 5 404888 31 79339464
Haemoglobin decreased 11.72 9.72 1294 403599 220825 79118670
Toxic shock syndrome 11.71 9.72 22 404871 1227 79338268
Erythema 11.70 9.72 975 403918 222315 79117180
Flushing 11.65 9.72 350 404543 87918 79251577
Personality change 11.64 9.72 90 404803 10080 79329415
Nasal polyps 11.63 9.72 12 404881 7315 79332180
Gastroenteritis viral 11.61 9.72 76 404817 24755 79314740
Dermatitis bullous 11.60 9.72 117 404776 14128 79325367
Basal ganglia haemorrhage 11.60 9.72 26 404867 1645 79337850
Anaemia vitamin B12 deficiency 11.60 9.72 17 404876 771 79338724
Diffuse large B-cell lymphoma 11.57 9.72 28 404865 12121 79327374
Syringe issue 11.57 9.72 9 404884 6289 79333206
Preternatural anus 11.56 9.72 7 404886 98 79339397
Urinary bladder polyp 11.54 9.72 10 404883 251 79339244
Illness anxiety disorder 11.54 9.72 10 404883 251 79339244
Cutis laxa 11.48 9.72 8 404885 144 79339351
Dry eye 11.42 9.72 126 404767 36805 79302690
Device related infection 11.42 9.72 115 404778 34179 79305316
Pneumonia viral 11.42 9.72 18 404875 9140 79330355
Pseudoporphyria 11.42 9.72 15 404878 613 79338882
Infusion site erythema 11.41 9.72 19 404874 9441 79330054
Psychiatric decompensation 11.41 9.72 3 404890 3960 79335535
Prerenal failure 11.41 9.72 43 404850 3655 79335840
Drug dose omission by device 11.39 9.72 9 404884 6241 79333254
Impatience 11.34 9.72 15 404878 617 79338878
Femoral artery aneurysm 11.34 9.72 9 404884 199 79339296
Nasal ulcer 11.33 9.72 30 404863 2110 79337385
Movement disorder 11.31 9.72 198 404695 27061 79312434
Mean cell haemoglobin decreased 11.30 9.72 9 404884 6215 79333280
Hepatic encephalopathy 11.28 9.72 74 404819 24092 79315403
Erythromelalgia 11.26 9.72 9 404884 201 79339294
Barrett's oesophagus 11.25 9.72 17 404876 792 79338703
Cerebral haematoma 11.25 9.72 74 404819 7868 79331627
Respiratory fatigue 11.24 9.72 10 404883 260 79339235
Disorientation 11.24 9.72 407 404486 62369 79277126
Tongue disorder 11.22 9.72 35 404858 13940 79325555
Epididymitis 11.20 9.72 28 404865 1902 79337593
Lipodystrophy acquired 11.15 9.72 4 404889 4321 79335174
Large intestine polyp 11.15 9.72 106 404787 12602 79326893
Paradoxical drug reaction 11.14 9.72 12 404881 7173 79332322
Neuropathy peripheral 11.12 9.72 595 404298 140710 79198785
Partner stress 11.10 9.72 11 404882 329 79339166
Blood creatine phosphokinase 11.07 9.72 8 404885 153 79339342
Azotaemia 11.06 9.72 76 404817 8200 79331295
Psychological trauma 11.05 9.72 23 404870 1383 79338112
Vulvovaginal burning sensation 11.05 9.72 25 404868 1592 79337903
Throat irritation 11.02 9.72 144 404749 40802 79298693
Basal cell carcinoma 11.02 9.72 258 404635 37117 79302378
Thalamic infarction 11.00 9.72 22 404871 1285 79338210
Drug monitoring procedure not performed 11.00 9.72 19 404874 992 79338503
Renal cell carcinoma recurrent 11.00 9.72 4 404889 15 79339480
Hyperprolactinaemia 10.95 9.72 5 404888 4671 79334824
Varicose vein 10.94 9.72 48 404845 4371 79335124
Gastritis haemorrhagic 10.92 9.72 34 404859 2623 79336872
Articular calcification 10.90 9.72 9 404884 211 79339284
Portal hypertension 10.88 9.72 12 404881 7096 79332399
Multiple allergies 10.86 9.72 23 404870 10437 79329058
Hepatic enzyme decreased 10.85 9.72 8 404885 158 79339337
Pelvic mass 10.85 9.72 21 404872 1198 79338297
Blood urine present 10.83 9.72 160 404733 21137 79318358
Lichen planus 10.82 9.72 35 404858 2756 79336739
Walking aid user 10.80 9.72 22 404871 10126 79329369
Multiple endocrine neoplasia 10.80 9.72 3 404890 3 79339492
Calculus prostatic 10.80 9.72 3 404890 3 79339492
Throat lesion 10.79 9.72 12 404881 411 79339084
Daydreaming 10.77 9.72 18 404875 915 79338580
Androgenetic alopecia 10.76 9.72 8 404885 160 79339335
Vein discolouration 10.70 9.72 11 404882 344 79339151
Product used for unknown indication 10.69 9.72 24 404869 1520 79337975
Skin toxicity 10.69 9.72 16 404877 8298 79331197
Oedema 10.67 9.72 497 404396 119083 79220412
Stent placement 10.64 9.72 63 404830 6457 79333038
Raynaud's phenomenon 10.64 9.72 19 404874 1019 79338476
Overdose 10.63 9.72 798 404095 183408 79156087
Premature baby 10.63 9.72 3 404890 3777 79335718
Polycystic ovaries 10.62 9.72 3 404890 3776 79335719
Pulmonary toxicity 10.62 9.72 32 404861 12882 79326613
Red blood cell count decreased 10.59 9.72 217 404676 57296 79282199
Eructation 10.59 9.72 93 404800 10816 79328679
Injection site warmth 10.59 9.72 39 404854 14768 79324727
Breast atrophy 10.56 9.72 6 404887 74 79339421
Herbal interaction 10.52 9.72 13 404880 499 79338996
Acute myeloid leukaemia 10.52 9.72 103 404790 30782 79308713
Alanine aminotransferase abnormal 10.52 9.72 18 404875 8849 79330646
Hypoaesthesia 10.51 9.72 776 404117 178576 79160919
Tongue biting 10.50 9.72 29 404864 2092 79337403
Peripheral ischaemia 10.44 9.72 83 404810 9374 79330121
Lymph node palpable 10.43 9.72 8 404885 168 79339327
Myocarditis 10.43 9.72 66 404827 21667 79317828
Bone pain 10.36 9.72 210 404683 55532 79283963
Coagulation time prolonged 10.32 9.72 32 404861 2463 79337032
Tongue dry 10.32 9.72 20 404873 1142 79338353
Meibomianitis 10.29 9.72 6 404887 78 79339417
Gallbladder enlargement 10.29 9.72 25 404868 1668 79337827
Pancreatic neoplasm 10.29 9.72 23 404870 1453 79338042
Occult blood positive 10.28 9.72 65 404828 6818 79332677
Cerebellar ischaemia 10.28 9.72 9 404884 229 79339266
Adenocarcinoma pancreas 10.26 9.72 28 404865 2005 79337490
Motor neurone disease 10.25 9.72 14 404879 594 79338901
Alcohol interaction 10.25 9.72 6 404887 4868 79334627
Product substitution issue 10.23 9.72 152 404741 20104 79319391
Pancreatitis chronic 10.22 9.72 44 404849 3975 79335520
Rotator cuff syndrome 10.18 9.72 113 404780 13982 79325513
Product storage error 10.17 9.72 45 404848 16181 79323314
Drug level above therapeutic 10.08 9.72 18 404875 8705 79330790
Joint injury 10.06 9.72 106 404787 31229 79308266
Carcinoma in situ of skin 10.04 9.72 8 404885 178 79339317
Acoustic neuroma 10.04 9.72 10 404883 301 79339194
PCO2 decreased 10 9.72 37 404856 3117 79336378
Coordination abnormal 9.99 9.72 133 404760 17179 79322316
Scleroderma 9.96 9.72 8 404885 5502 79333993
Social fear 9.93 9.72 4 404889 21 79339474
Activated partial thromboplastin time shortened 9.92 9.72 17 404876 882 79338613
Eyelid infection 9.87 9.72 11 404882 378 79339117
Myoglobinaemia 9.86 9.72 7 404886 130 79339365
Peripheral embolism 9.85 9.72 27 404866 1939 79337556
Gallbladder neoplasm 9.85 9.72 6 404887 85 79339410
Penile oedema 9.82 9.72 10 404883 309 79339186
Sarcoidosis 9.82 9.72 17 404876 8318 79331177
Thrombosis in device 9.81 9.72 54 404839 5388 79334107
Gastric mucosa erythema 9.77 9.72 11 404882 382 79339113
Product preparation error 9.76 9.72 9 404884 5784 79333711
Hyperlactacidaemia 9.75 9.72 55 404838 5540 79333955
Prostate examination abnormal 9.74 9.72 8 404885 186 79339309
Renal tubular necrosis 9.73 9.72 180 404713 24859 79314636
Dental plaque 9.73 9.72 6 404887 87 79339408

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BH51 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors
ATC C10AA01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA02 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX01 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX04 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:35664 hydroxymethylglutaryl-CoA reductase inhibitors
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:77255 lethal toxin inhibitors
CHEBI has role CHEBI:173085 ferroptosis inducers
CHEBI has role CHEBI:176497 geroprotectors
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Hypoalphalipoproteinemia indication 190785000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Prevention of Transient Ischemic Attacks indication
Slow Progression of Coronary Artery Disease indication
Myocardial Infarction Prevention indication
Alopecia areata off-label use 68225006 DOID:986
Primary Prevention of Coronary Heart Disease off-label use
Myocardial Reinfarction Prevention off-label use
Hypophosphatemia contraindication 4996001
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Low blood pressure contraindication 45007003
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Gout contraindication 90560007 DOID:13189
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Hemorrhagic cerebral infarction contraindication 230706003
Arterial hemorrhage contraindication 234003006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Surgical procedure contraindication 387713003
Acute coronary syndrome contraindication 394659003
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Myopathy related to SLCO1B1 Gene Variant contraindication
SLCO1B1 Gene Variant for OATP1B1 Transporter Affecting Hepatic Clearance contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG;EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Oct. 7, 2011 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
10MG;EQ 50MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Sept. 18, 2012 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
20MG;EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Oct. 7, 2011 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
20MG;EQ 50MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Sept. 18, 2012 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
40MG;EQ 100MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Oct. 7, 2011 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE
40MG;EQ 50MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** JUVISYNC MERCK SHARP DOHME N202343 Sept. 18, 2012 DISCN TABLET ORAL 7326708 April 11, 2026 METHOD OF TREATING TYPE 2 DIABETES MELLITUS IN PATIENTS FOR WHOM TREATMENT WITH BOTH SITAGLIPTIN AND SIMVASTATIN IS APPROPRIATE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 7.77 WOMBAT-PK CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Nuclear receptor subfamily 4 group A member 2 Nuclear other EC50 5.29 CHEMBL
Acetylcholinesterase Enzyme Ki 5.74 CHEMBL
Cholinesterase Enzyme Ki 6.12 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.02 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.37 CHEMBL

External reference:

IDSource
4020400 VUID
N0000148200 NUI
D00434 KEGG_DRUG
4020400 VANDF
C0074554 UMLSCUI
CHEBI:9150 CHEBI
CHEMBL1064 ChEMBL_ID
D019821 MESH_DESCRIPTOR_UI
DB00641 DRUGBANK_ID
54454 PUBCHEM_CID
2955 IUPHAR_LIGAND_ID
6147 INN_ID
AGG2FN16EV UNII
36567 RXNORM
5465 MMSL
82969 MMSL
d00746 MMSL
003621 NDDF
387584000 SNOMEDCT_US
96304005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ZOCOR HUMAN PRESCRIPTION DRUG LABEL 1 0006-0543 TABLET, FILM COATED 80 mg ORAL NDA 31 sections
ZOCOR HUMAN PRESCRIPTION DRUG LABEL 1 0006-0735 TABLET, FILM COATED 10 mg ORAL NDA 31 sections
ZOCOR HUMAN PRESCRIPTION DRUG LABEL 1 0006-0740 TABLET, FILM COATED 20 mg ORAL NDA 31 sections
ZOCOR HUMAN PRESCRIPTION DRUG LABEL 1 0006-0749 TABLET, FILM COATED 40 mg ORAL NDA 31 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7992 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7992 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7992 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7993 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7993 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-7993 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-8056 TABLET, FILM COATED 40 mg ORAL ANDA 26 sections
SIMVASTATIN HUMAN PRESCRIPTION DRUG LABEL 1 0615-8056 TABLET, FILM COATED 40 mg ORAL ANDA 26 sections
Simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-486 TABLET, FILM COATED 20 mg ORAL ANDA 25 sections
Simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-487 TABLET, FILM COATED 40 mg ORAL ANDA 25 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-907 TABLET, FILM COATED 80 mg ORAL ANDA 27 sections
simvastatin HUMAN PRESCRIPTION DRUG LABEL 1 10544-908 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-050 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-051 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-052 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-053 TABLET, FILM COATED 40 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 13107-054 TABLET, FILM COATED 80 mg ORAL ANDA 27 sections
Simvastatin Human Prescription Drug Label 1 16714-681 TABLET, FILM COATED 5 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-681 TABLET, FILM COATED 5 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-681 TABLET, FILM COATED 5 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-681 TABLET, FILM COATED 5 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-682 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-682 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-682 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-682 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Simvastatin Human Prescription Drug Label 1 16714-683 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections