gemigliptin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dipeptidyl aminopeptidase-IV inhibitors 4833 911637-19-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gemigliptin
  • zemiglo
  • LC15-0444
Dipeptidyl Peptidase IV Inhibitors; orally active small molecule for the treatment of type II diabetes
  • Molecular weight: 489.37
  • Formula: C18H19F8N5O2
  • CLOGP: 0.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 92.42
  • ALOGS: -3.77
  • ROTB: 6

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 27, 2012 Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BD18 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC A10BH06 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors
ATC A10BH52 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.86 Basic
pKa2 0.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dipeptidyl peptidase 4 Enzyme INHIBITOR IC50 7.80 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Dipeptidyl peptidase 9 Enzyme IC50 4.33 SCIENTIFIC LITERATURE

External reference:

IDSource
D10502 KEGG_DRUG
C3501981 UMLSCUI
CHEBI:134731 CHEBI
CHEMBL3707235 ChEMBL_ID
DB12412 DRUGBANK_ID
C534891 MESH_SUPPLEMENTAL_RECORD_UI
9291 INN_ID
5DHU18M5D6 UNII
11953153 PUBCHEM_CID

Pharmaceutical products:

None