oxaceprol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2005 33996-33-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxaceprol
  • N-Acetyl-4-hydroxy-L-proline
  • N-Acetyl-4-hydroxyproline
  • N-Acetyl-L-hydroxyproline
  • N-Acetyl-trans-4-hydroxy-L-proline
  • N-Acetylhydroxyproline
Oxaceprol, is an atypical inhibitor of inflammation which helps in reduction of leukocyte adherence for joint diseases. This medicine is used for osteoarthritis or degenerative joint disorders and inflammation of connective tissues.
  • Molecular weight: 173.17
  • Formula: C7H11NO4
  • CLOGP: -1.91
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 77.84
  • ALOGS: 0.57
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -2.579 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.288 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.300 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 1.312 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 77.460 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 42.970 % Moderate 0.67
herg hERG pIC50 4.656 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 1.112 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 3.443 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 67.880 % Moderate 0.67
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 39
kinase-selectivity-class ACVR2B,AXL,BMX,BRAF,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAP3K14,MAPK7,PIK3CD,PIK3CG,PRKDC,STK33,SYK,TEK,TGFBR1 19
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.877 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 0.638 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 84.030 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.052 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 79.920 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 0.895 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 73.360 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 87.600 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 822.243 uM Moderate 0.67

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX09 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC M01AX24 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids
MeSH PA D003879 Dermatologic Agents
MeSH PA D018501 Antirheumatic Agents
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:50177 dermatologic drug

Related Drugs by ATC class:

D11AX Other dermatologicals 20 drugs
aminobenzoic acidbrimonidinecaffeinecalcium gluconatedeoxycholic aciddiclofenaceflornithinefinasteridegamolenic acidhydrogen peroxidehydroquinoneivermectin show all 20 →
M01AX Other antiinflammatory and antirheumatic agents, non-steroids 13 drugs
azapropazonebenzydaminechondroitin sulfatediacereinfeprazoneglucosaminemorniflumatenabumetoneniflumic acidnimesulideorgoteinproquazone show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.67 acidic
pKa2 13.57 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07215 KEGG_DRUG
C0064164 UMLSCUI
CHEBI:233149 CHEBI
CHEMBL1407356 ChEMBL_ID
DB13363 DRUGBANK_ID
65784 PUBCHEM_CID
3891 INN_ID
C012393 MESH_SUPPLEMENTAL_RECORD_UI
Q0XV76B96L UNII
28068 RXNORM
006313 NDDF
713480005 SNOMEDCT_US

Pharmaceutical products:

None