morniflumate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4672 65847-85-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • morniflumate
  • Molecular weight: 395.38
  • Formula: C19H20F3N3O3
  • CLOGP: 4.51
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 63.69
  • ALOGS: -3.66
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,EIF2AK3,ERBB2,GRK2,MAPK7,MARK4,NTRK2,PDK2,PDK4,PRKDC,STK33,TTK 18
kinase-selectivity-class AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,FLT3,JAK1,MAP3K21,MAPK7,MARK4,MTOR,PDK4,PRKCD,SIK2,SIK3,STK33,TTK 18
pfas-class PFAS structural alert (1 = True, 0 = False) 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Obstructive airways disorder 484.94 37.67 183 8316 24576 42588260
Full blood count abnormal 430.99 37.67 177 8322 29699 42583137
Wheezing 356.88 37.67 187 8312 54594 42558242
Neuritis 345.20 37.67 101 8398 6119 42606717
Pulmonary vasculitis 340.07 37.67 100 8399 6166 42606670
Asthma 334.25 37.67 187 8312 62127 42550709
Loss of personal independence in daily activities 304.37 37.67 163 8336 49653 42563183
Neurological symptom 298.08 37.67 101 8398 9890 42602946
Therapeutic product effect incomplete 293.62 37.67 180 8319 70759 42542077
Respiratory symptom 291.45 37.67 102 8397 11004 42601832
Dust allergy 284.51 37.67 84 8415 5248 42607588
Eosinophilic granulomatosis with polyangiitis 284.18 37.67 94 8405 8544 42604292
Total lung capacity abnormal 263.56 37.67 76 8423 4367 42608469
Pulmonary alveolar haemorrhage 259.24 37.67 101 8398 14715 42598121
Sleep disorder due to a general medical condition 246.60 37.67 102 8397 17351 42595485
Vasculitis 244.77 37.67 103 8396 18291 42594545
Forced expiratory volume decreased 242.85 37.67 81 8418 7549 42605287
Productive cough 223.80 37.67 135 8364 51432 42561404
Mite allergy 219.78 37.67 68 8431 4978 42607858
Mycotic allergy 217.62 37.67 67 8432 4824 42608012
Spirometry abnormal 210.09 37.67 66 8433 5080 42607756
Conjunctivitis allergic 209.19 37.67 68 8431 5843 42606993
Antineutrophil cytoplasmic antibody positive 203.58 37.67 62 8437 4303 42608533
Pulmonary fibrosis 202.16 37.67 101 8398 26580 42586256
Normochromic normocytic anaemia 180.98 37.67 68 8431 8963 42603873
Hypothyroidism 179.08 37.67 99 8400 31985 42580851
Malignant melanoma in situ 171.53 37.67 49 8450 2718 42610118
Congenital hiatus hernia 170.73 37.67 59 8440 6115 42606721
Nodule 169.39 37.67 71 8428 12463 42600373
Haemoptysis 165.24 37.67 107 8392 46060 42566776
Lung disorder 149.58 37.67 102 8397 47821 42565015
Benign prostatic hyperplasia 145.71 37.67 75 8424 20977 42591859
Arteriosclerosis 138.86 37.67 69 8430 17920 42594916
Arteriosclerosis coronary artery 136.40 37.67 69 8430 18608 42594228
Micturition urgency 133.16 37.67 59 8440 11839 42600997
Breath sounds abnormal 132.24 37.67 59 8440 12034 42600802
Hypercholesterolaemia 128.81 37.67 59 8440 12790 42600046
Joint injury 121.33 37.67 59 8440 14617 42598219
Capillaritis 118.35 37.67 35 8464 2193 42610643
Bronchiectasis 109.89 37.67 59 8440 17960 42594876
Chronic obstructive pulmonary disease 107.99 37.67 94 8405 63020 42549816
Anxiety 104.08 37.67 123 8376 118437 42494399
Dyspnoea exertional 82.35 37.67 73 8426 50075 42562761
Dyspnoea 79.75 37.67 230 8269 442391 42170445
Transient ischaemic attack 78.18 37.67 60 8439 33679 42579157
Gastrooesophageal reflux disease 66.95 37.67 62 8437 44961 42567875
Allergy to animal 63.85 37.67 16 8483 534 42612302
Hypoxia 62.12 37.67 73 8426 69713 42543123
Coronary artery disease 55.97 37.67 61 8438 53659 42559177
Thrombosis 53.37 37.67 67 8432 68444 42544392
Pain in extremity 48.21 37.67 98 8401 150506 42462330
Muscular dystrophy 42.76 37.67 9 8490 135 42612701
Perineal infection 37.96 37.67 11 8488 641 42612195

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Obstructive airways disorder 496.63 39.35 169 7959 45980 110535191
Full blood count abnormal 442.19 39.35 163 7965 55889 110525282
Pulmonary vasculitis 439.92 39.35 101 8027 6459 110574712
Neuritis 433.06 39.35 102 8026 7297 110573874
Respiratory symptom 366.45 39.35 103 8025 14842 110566329
Eosinophilic granulomatosis with polyangiitis 361.90 39.35 95 8033 10591 110570580
Neurological symptom 357.52 39.35 102 8026 15506 110565665
Total lung capacity abnormal 341.96 39.35 77 8051 4506 110576665
Pulmonary alveolar haemorrhage 331.80 39.35 102 8026 20048 110561123
Vasculitis 292.57 39.35 107 8021 35766 110545405
Forced expiratory volume decreased 283.36 39.35 82 8046 13094 110568077
Mite allergy 282.67 39.35 69 8059 5734 110575437
Dust allergy 280.37 39.35 69 8059 5932 110575239
Spirometry abnormal 276.12 39.35 67 8061 5430 110575741
Mycotic allergy 275.84 39.35 68 8060 5886 110575285
Conjunctivitis allergic 270.49 39.35 69 8059 6862 110574309
Antineutrophil cytoplasmic antibody positive 260.75 39.35 63 8065 5013 110576158
Productive cough 254.88 39.35 137 7991 114168 110467003
Loss of personal independence in daily activities 251.16 39.35 149 7979 149871 110431300
Therapeutic product effect incomplete 237.92 39.35 167 7961 223638 110357533
Asthma 234.60 39.35 173 7955 250118 110331053
Congenital hiatus hernia 232.93 39.35 60 8068 6199 110574972
Wheezing 229.34 39.35 172 7956 255058 110326113
Haemoptysis 227.64 39.35 109 8019 71245 110509926
Normochromic normocytic anaemia 227.24 39.35 69 8059 12988 110568183
Benign prostatic hyperplasia 224.50 39.35 74 8054 18160 110563011
Malignant melanoma in situ 208.05 39.35 49 8079 3493 110577678
Hypothyroidism 198.57 39.35 100 8028 72799 110508372
Sleep disorder due to a general medical condition 188.96 39.35 87 8041 52025 110529146
Arteriosclerosis 187.57 39.35 70 8058 24697 110556474
Arteriosclerosis coronary artery 186.61 39.35 70 8058 25048 110556123
Nodule 175.64 39.35 72 8056 32559 110548612
Pulmonary fibrosis 174.91 39.35 103 8025 101939 110479232
Micturition urgency 166.25 39.35 60 8068 19260 110561911
Breath sounds abnormal 150.27 39.35 60 8068 25344 110555827
Capillaritis 149.85 39.35 35 8093 2404 110578767
Bronchiectasis 129.35 39.35 60 8068 36433 110544738
Joint injury 124.11 39.35 60 8068 39934 110541237
Lung disorder 122.09 39.35 103 8025 179944 110401227
Chronic obstructive pulmonary disease 103.19 39.35 76 8052 109082 110472089
Transient ischaemic attack 100.23 39.35 61 8067 63921 110517250
Dyspnoea exertional 97.34 39.35 72 8056 103988 110477183
Anxiety 95.57 39.35 122 8006 344956 110236215
Coronary artery disease 93.85 39.35 61 8067 71629 110509542
Hypoxia 89.60 39.35 75 8053 129440 110451731
Thrombosis 88.01 39.35 69 8059 108593 110472578
Hypercholesterolaemia 78.60 39.35 60 8068 90777 110490394
Dyspnoea 77.41 39.35 216 7912 1106656 109474515
Pulmonary embolism 56.41 39.35 74 8054 214400 110366771
Gastrooesophageal reflux disease 50.29 39.35 64 8064 179912 110401259
Scrotal infection 46.89 39.35 11 8117 769 110580402
Muscular dystrophy 46.84 39.35 9 8119 239 110580932
Optic nerve operation 46.23 39.35 10 8118 484 110580687
Perineal infection 45.73 39.35 11 8117 856 110580315
Infected dermal cyst 40.91 39.35 11 8117 1337 110579834
Pain in extremity 39.82 39.35 101 8027 487017 110094154
Tooth injury 39.61 39.35 12 8116 2234 110578937

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AX22 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids

Related Drugs by ATC class:

M01AX Other antiinflammatory and antirheumatic agents, non-steroids 13 drugs
azapropazonebenzydaminechondroitin sulfatediacereinfeprazoneglucosaminenabumetoneniflumic acidnimesulideorgoteinoxaceprolproquazone show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.19 Basic
pKa2 3.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05078 KEGG_DRUG
CHEBI:136018 CHEBI
CHEMBL2105059 ChEMBL_ID
C027859 MESH_SUPPLEMENTAL_RECORD_UI
4587 INN_ID
DB09285 DRUGBANK_ID
R133MWH7X1 UNII
30225 RXNORM
005306 NDDF
773471007 SNOMEDCT_US
C0066803 UMLSCUI
72106 PUBCHEM_CID

Pharmaceutical products:

None