morniflumate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4672	65847-85-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: morniflumate	Molecular weight: 395.38 Formula: C19H20F3N3O3 CLOGP: 4.51 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 63.69 ALOGS: -3.66 ROTB: 8

Molecule

Description

Molfile Inchi Smiles

Synonyms:

morniflumate

Molecular weight: 395.38
Formula: C19H20F3N3O3
CLOGP: 4.51
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 63.69
ALOGS: -3.66
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Obstructive airways disorder	88.10	27.34	38	3204	15456	34938233
Full blood count abnormal	66.15	27.34	33	3209	18635	34935054
Wheezing	60.15	27.34	41	3201	41361	34912328
Benign prostatic hyperplasia	55.45	27.34	27	3215	14468	34939221
Congenital hiatus hernia	53.57	27.34	13	3229	831	34952858
Asthma	52.11	27.34	38	3204	42618	34911071
Chronic obstructive pulmonary disease	51.80	27.34	40	3202	48878	34904811
Loss of personal independence in daily activities	50.91	27.34	34	3208	33145	34920544
Sleep disorder due to a general medical condition	47.61	27.34	18	3224	5203	34948486
Perineal infection	46.54	27.34	11	3231	628	34953061
Scrotal infection	46.30	27.34	11	3231	642	34953047
Malignant melanoma in situ	44.33	27.34	13	3229	1715	34951974
Tooth injury	44.25	27.34	12	3230	1193	34952496
Optic nerve operation	44.00	27.34	10	3232	480	34953209
Respiratory symptom	43.83	27.34	13	3229	1784	34951905
Infected dermal cyst	42.87	27.34	11	3231	883	34952806
Therapeutic product effect incomplete	42.23	27.34	36	3206	50505	34903184
Pulmonary vasculitis	36.86	27.34	9	3233	590	34953099
Arteriovenous fistula	35.87	27.34	10	3232	1101	34952588
Intracranial aneurysm	35.76	27.34	11	3231	1707	34951982
Anal haemorrhage	35.25	27.34	12	3230	2566	34951123
Allergy to animal	34.86	27.34	8	3234	401	34953288
Tendon pain	33.49	27.34	12	3230	2983	34950706
Dust allergy	33.16	27.34	9	3233	897	34952792
Neuritis	32.89	27.34	9	3233	925	34952764
Infusion site haemorrhage	32.25	27.34	9	3233	995	34952694
Umbilical hernia	31.66	27.34	13	3229	4664	34949025
Device dislocation	31.19	27.34	14	3228	6235	34947454
Dermal cyst	30.75	27.34	10	3232	1857	34951832
Oxygen saturation decreased	30.71	27.34	31	3211	53787	34899902
Nasopharyngitis	30.60	27.34	35	3207	69933	34883756
Blood pressure fluctuation	29.69	27.34	22	3220	25227	34928462
Granulocyte count increased	29.55	27.34	7	3235	403	34953286
Neuralgia	29.39	27.34	18	3224	15095	34938594
Micturition urgency	27.50	27.34	13	3229	6512	34947177

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Benign prostatic hyperplasia	81.89	27.13	26	2848	11586	79729928
Obstructive airways disorder	69.55	27.13	30	2844	31429	79710085
Congenital hiatus hernia	66.12	27.13	13	2861	811	79740703
Scrotal infection	57.36	27.13	11	2863	602	79740912
Perineal infection	54.34	27.13	11	2863	796	79740718
Optic nerve operation	53.43	27.13	10	2864	480	79741034
Malignant melanoma in situ	52.00	27.13	13	2861	2439	79739075
Infected dermal cyst	49.47	27.13	11	2863	1247	79740267
Tooth injury	49.31	27.13	12	2862	2016	79739498
Full blood count abnormal	47.59	27.13	25	2849	40449	79701065
Respiratory symptom	43.38	27.13	13	2861	4778	79736736
Arteriovenous fistula	43.29	27.13	10	2864	1344	79740170
Pulmonary vasculitis	43.18	27.13	9	2865	752	79740762
Umbilical hernia	40.83	27.13	13	2861	5832	79735682
Anal haemorrhage	40.56	27.13	12	2862	4222	79737292
Wheezing	39.34	27.13	33	2841	116631	79624883
Tendon pain	37.13	27.13	12	2862	5646	79735868
Chronic obstructive pulmonary disease	37.00	27.13	28	2846	85391	79656123
Dermal cyst	36.32	27.13	10	2864	2722	79738792
Neuritis	35.68	27.13	9	2865	1749	79739765
Intracranial aneurysm	35.45	27.13	11	2863	4539	79736975
Anal fistula	34.72	27.13	12	2862	6932	79734582
Vasculitis	33.82	27.13	17	2857	25085	79716429
Micturition urgency	31.05	27.13	13	2861	12628	79728886
Oxygen saturation decreased	30.69	27.13	30	2844	129017	79612497
Loss of personal independence in daily activities	30.48	27.13	27	2847	102553	79638961
Asthma	29.53	27.13	30	2844	135065	79606449
Infusion site haemorrhage	29.01	27.13	9	2865	3711	79737803
Granulocyte count increased	28.18	27.13	7	2867	1278	79740236
Breath sounds abnormal	28.12	27.13	13	2861	15971	79725543

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M01AX22	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Other antiinflammatory and antirheumatic agents, non-steroids

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.19	Basic
pKa2	3.73	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D05078	KEGG_DRUG
CHEMBL2105059	ChEMBL_ID
C027859	MESH_SUPPLEMENTAL_RECORD_UI
4587	INN_ID
DB09285	DRUGBANK_ID
R133MWH7X1	UNII
30225	RXNORM
005306	NDDF
773471007	SNOMEDCT_US
C0066803	UMLSCUI
72106	PUBCHEM_CID

Pharmaceutical products:

None