diacerein 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
849 13739-02-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diacerein
  • artrodar
  • diacerhein
  • diacetylrhein
  • fisiodar
chelates with bivalent metals; a quinone which possesses redox properties; metabolized to active rhein; proposed mechanisms include inhibiting IL1 and metalloproteinases; called a slow acting symptomatic drug in osteoarthritis; no effect of cyclooxygenase
  • Molecular weight: 368.30
  • Formula: C19H12O8
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 124.04
  • ALOGS: -3.96
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Brain scan abnormal 146.50 64.89 21 388 1147 64497176
Cerebral artery thrombosis 140.49 64.89 20 389 1039 64497284
Areflexia 115.96 64.89 21 388 4986 64493337
Hemiplegia 85.23 64.89 19 390 12749 64485574
Ischaemic stroke 84.01 64.89 22 387 29013 64469310
Facial paralysis 77.75 64.89 19 390 18947 64479376
Disease recurrence 77.49 64.89 21 388 31489 64466834
Respiratory distress 71.19 64.89 22 387 52309 64446014

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AX21 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids
MeSH PA D000893 Anti-Inflammatory Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.67 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Caspase-3 Enzyme EC50 5.10 CHEMBL
Caspase-7 Enzyme EC50 4.83 CHEMBL
N-acylethanolamine-hydrolyzing acid amidase Enzyme IC50 6.16 CHEMBL
Female germline-specific tumor suppressor gld-1 Unclassified IC50 5.14 CHEMBL

External reference:

IDSource
D07270 KEGG_DRUG
22759 RXNORM
C0057678 UMLSCUI
CHEBI:94708 CHEBI
CHEMBL41286 ChEMBL_ID
DB11994 DRUGBANK_ID
C025292 MESH_SUPPLEMENTAL_RECORD_UI
26248 PUBCHEM_CID
10800 IUPHAR_LIGAND_ID
5371 INN_ID
4HU6J11EL5 UNII
005800 NDDF
702835000 SNOMEDCT_US
714674003 SNOMEDCT_US

Pharmaceutical products:

None