glucosamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1307 3416-24-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glucosamine
  • Molecular weight: 179.17
  • Formula: C6H13NO5
  • CLOGP: -2.18
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 5
  • TPSA: 116.17
  • ALOGS: 0.49
  • ROTB: 1

Drug dosage:

DoseUnitRoute
1.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 26 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.443 Moderate 0.65
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.002 Moderate 0.65
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.564 10^-6 cm/s Moderate 0.65
dh-clint Dog hepatocyte intrinsic clearance 0.594 uL/min/10^6 cells Moderate 0.65
dppb Dog plasma protein binding (% unbound) 83.930 % Moderate 0.65
fcs-ppb Fetal calf serum protein binding (% unbound) 90.380 % Moderate 0.65
herg hERG pIC50 4.307 pIC50 Moderate 0.65
hh-clint Human hepatocyte intrinsic clearance 0.942 uL/min/10^6 cells Moderate 0.65
hlm-clint Human liver microsomal intrinsic clearance 3.656 uL/min/mg protein Moderate 0.65
hppb Human plasma protein binding (% unbound) 75.850 % Moderate 0.65
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK1,NTRK2,PDK2,PDK4,PIK3CD,PRKDC,SIK2,TEK 26
kinase-selectivity-class ACVRL1,CDK1,CDK2,CHUK,DYRK1A,IRAK4,MAP2K6,MAP3K14,PDK1,PIK3CD,ZAP70 11
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.383 Moderate 0.65
mh-clint Mouse hepatocyte intrinsic clearance 0.832 Moderate 0.65
mppb Mouse plasma protein binding (% unbound) 92.930 Moderate 0.65
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.414 Moderate 0.65
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 93.270 % Moderate 0.65
rh-clint Rat hepatocyte intrinsic clearance 2.183 uL/min/10^6 cells Moderate 0.65
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.860 % Moderate 0.65
rppb Rat plasma protein binding (% unbound) 89.830 % Moderate 0.65
solubility-dd Solubility at pH 7.4 in DMSO 870.964 uM Moderate 0.65

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip dry 583.82 30.25 698 120765 100257 90406727
Muscle injury 563.35 30.25 917 120546 175737 90331247
Creatinine renal clearance decreased 555.75 30.25 335 121128 18564 90488420
Mobility decreased 552.44 30.25 1108 120355 249626 90257358
Sedation complication 549.65 30.25 320 121143 16624 90490360
Liver injury 541.97 30.25 884 120579 169683 90337301
Deep vein thrombosis postoperative 517.45 30.25 553 120910 70256 90436728
Duodenal ulcer perforation 507.98 30.25 995 120468 220293 90286691
Helicobacter infection 465.90 30.25 974 120489 225876 90281108
Autoimmune disorder 465.76 30.25 544 120919 76200 90430784
Joint range of motion decreased 448.47 30.25 716 120747 134927 90372057
Lower limb fracture 444.85 30.25 559 120904 84454 90422530
Type 2 diabetes mellitus 441.28 30.25 893 120570 202351 90304633
Psoriatic arthropathy 436.18 30.25 952 120511 227383 90279601
Folliculitis 434.34 30.25 890 120573 203463 90303521
Lower respiratory tract infection 426.39 30.25 998 120465 249661 90257323
Orthostatic hypotension 411.42 30.25 384 121079 41443 90465541
Blood calcium decreased 409.79 30.25 333 121130 29849 90477135
Fibromyalgia 408.79 30.25 873 120590 205396 90301588
Blood cholesterol increased 408.37 30.25 877 120586 207135 90299849
Pericarditis 403.43 30.25 1023 120440 269128 90237856
Irritable bowel syndrome 403.09 30.25 871 120592 206577 90300407
Swollen joint count increased 400.97 30.25 611 120852 110595 90396389
Anti-cyclic citrullinated peptide antibody positive 390.82 30.25 931 120532 235502 90271482
Drug ineffective 389.53 30.25 797 120666 1383501 89123483
C-reactive protein abnormal 386.49 30.25 647 120816 126782 90380202
Peripheral venous disease 384.74 30.25 517 120946 83404 90423580
Injury 381.57 30.25 827 120636 196522 90310462
Rheumatoid factor positive 377.03 30.25 758 120705 170892 90336092
Night sweats 373.60 30.25 641 120822 128125 90378859
Adjustment disorder with depressed mood 367.38 30.25 416 121047 56337 90450647
Oedema 365.37 30.25 820 120643 199475 90307509
Bursitis 360.65 30.25 639 120824 131015 90375969
X-ray abnormal 358.98 30.25 370 121093 45054 90461930
Sedation 347.95 30.25 374 121089 47797 90459187
Sleep disorder due to general medical condition, insomnia type 347.84 30.25 621 120842 128073 90378911
Rheumatic fever 344.42 30.25 683 120780 152438 90354546
Anaemia 337.30 30.25 39 121424 352763 90154221
Acute kidney injury 336.85 30.25 24 121439 320363 90186621
Impaired healing 336.21 30.25 874 120589 233325 90273659
Facet joint syndrome 332.86 30.25 525 120938 97864 90409120
Lung disorder 332.83 30.25 665 120798 149218 90357766
Obesity 331.02 30.25 544 120919 104963 90402021
Stomatitis 330.65 30.25 961 120502 273737 90233247
Discomfort 327.59 30.25 957 120506 273378 90233606
Blister 317.44 30.25 903 120560 254095 90252889
Road traffic accident 315.08 30.25 538 120925 107088 90399896
Musculoskeletal pain 312.13 30.25 701 120762 170550 90336434
Hand deformity 311.88 30.25 989 120474 295373 90211611
Pemphigus 308.37 30.25 1051 120412 325813 90181171
Wound infection 307.70 30.25 529 120934 105873 90401111
Liver disorder 298.43 30.25 562 120901 120707 90386277
Cognitive disorder 297.56 30.25 414 121049 68993 90437991
Pulmonary fibrosis 292.07 30.25 520 120943 106983 90400001
Urticaria 289.22 30.25 999 120464 311735 90195249
Dislocation of vertebra 286.30 30.25 364 121099 55604 90451380
Wheezing 274.08 30.25 820 120643 237260 90269724
Gait inability 270.75 30.25 603 120860 145853 90361131
Breast cancer stage III 264.28 30.25 435 121028 84012 90422972
Dry mouth 252.92 30.25 676 120787 183383 90323601
Osteoarthritis 252.14 30.25 702 120761 195028 90311956
Death 251.88 30.25 150 121313 456401 90050583
Cough 246.76 30.25 93 121370 368869 90138115
C-reactive protein 241.51 30.25 252 121211 31115 90475869
Wound 240.41 30.25 921 120542 302059 90204925
Glossodynia 237.42 30.25 956 120507 320823 90186161
Contusion 223.03 30.25 792 120671 250424 90256560
Lupus vulgaris 220.94 30.25 287 121176 44772 90462212
Neutropenia 217.01 30.25 24 121439 224880 90282104
Urinary tract infection 212.91 30.25 72 121391 305560 90201424
Sciatica 212.10 30.25 439 121024 100943 90406041
Prescribed overdose 209.26 30.25 427 121036 97198 90409786
Product dose omission issue 206.18 30.25 67 121396 291620 90215364
Balance disorder 206.18 30.25 423 121040 96657 90410327
Erythema 203.17 30.25 32 121431 229214 90277770
Breast cancer stage II 201.91 30.25 243 121220 35091 90471893
Ulcer haemorrhage 201.81 30.25 211 121252 26110 90480874
Abdominal pain upper 201.29 30.25 931 120532 331743 90175241
Therapy non-responder 199.89 30.25 514 120949 136190 90370794
Systemic lupus erythematosus 199.59 30.25 986 120477 360910 90146074
Sepsis 199.39 30.25 10 121453 179804 90327180
Synovitis 196.69 30.25 919 120544 328833 90178151
Ill-defined disorder 196.06 30.25 619 120844 184272 90322712
Somnolence 195.07 30.25 25 121438 209059 90297925
Arthropathy 191.52 30.25 983 120480 365259 90141725
Depressed level of consciousness 182.32 30.25 340 121123 72444 90434540
Sleep disorder 176.25 30.25 625 120838 197405 90309579
Febrile neutropenia 174.95 30.25 9 121454 158340 90348644
Subcutaneous drug absorption impaired 172.44 30.25 144 121319 13401 90493583
Amnesia 172.26 30.25 421 121042 108084 90398900
Hepatic enzyme increased 172.01 30.25 944 120519 359792 90147192
Porphyria acute 169 30.25 161 121302 17814 90489170
Hypercholesterolaemia 167.17 30.25 398 121065 100494 90406490
Back pain 165.45 30.25 111 121352 317064 90189920
Gastrointestinal disorder 163.85 30.25 730 120733 255957 90251027
Delirium 163.63 30.25 403 121060 103956 90403028
Drug interaction 162.19 30.25 84 121379 276369 90230615
Seizure 161.56 30.25 11 121452 152618 90354366
Nausea 155.42 30.25 865 120598 1109451 89397533
Dehydration 153.55 30.25 36 121427 194411 90312573
Migraine 153.50 30.25 582 120881 189810 90317174
Confusional state 152.05 30.25 961 120502 385244 90121740
General physical health deterioration 152.01 30.25 903 120560 354212 90152772
Off label use 147.64 30.25 871 120592 1101381 89405603
Inflammation 143.19 30.25 545 120918 178047 90328937
Syncope 142.07 30.25 9 121454 132654 90374330
COVID-19 142.05 30.25 27 121436 168816 90338168
Renal failure 139.96 30.25 9 121454 130998 90375986
Grip strength decreased 139.34 30.25 352 121111 92224 90414760
Hip arthroplasty 138.73 30.25 312 121151 75896 90431088
Musculoskeletal stiffness 137.27 30.25 770 120693 295762 90211222
Rash vesicular 136.15 30.25 144 121319 18053 90488931
Pustular psoriasis 133.82 30.25 144 121319 18412 90488572
Chest pain 133.68 30.25 808 120655 318837 90188147
Rheumatoid arthritis 132.12 30.25 885 120578 361729 90145255
Respiratory failure 129.95 30.25 7 121456 118411 90388573
Malignant neoplasm progression 128.71 30.25 3 121460 106867 90400117
Injection site pain 127.90 30.25 37 121426 173662 90333322
Pulmonary embolism 126.05 30.25 14 121449 130806 90376178
Disease progression 125.63 30.25 28 121435 156587 90350397
Pregnancy 125.43 30.25 265 121198 61782 90445202
Nasopharyngitis 125.35 30.25 954 120509 406150 90100834
General symptom 124.08 30.25 124 121339 14544 90492440
Grip strength 121.83 30.25 99 121364 8866 90498118
Hyperhidrosis 120.79 30.25 19 121444 136286 90370698
Walking aid user 120.72 30.25 190 121273 35316 90471668
Swelling 120.19 30.25 966 120497 418092 90088892
Hyponatraemia 119.74 30.25 18 121445 133520 90373464
Cardiac arrest 119.03 30.25 5 121458 104930 90402054
Tremor 117.72 30.25 30 121433 153143 90353841
Platelet count decreased 117.15 30.25 21 121442 136948 90370036
Palpitations 116.86 30.25 21 121442 136707 90370277
Chest discomfort 116.65 30.25 22 121441 138343 90368641
Dysphagia 116.21 30.25 9 121454 112269 90394715
Chills 115.60 30.25 19 121444 131962 90375022
Pancytopenia 115.54 30.25 13 121450 120250 90386734
Haemoglobin decreased 114.73 30.25 37 121426 161919 90345065
Back disorder 114.47 30.25 156 121307 25475 90481509
Myalgia 113.89 30.25 46 121417 175079 90331905
Feeling abnormal 113.63 30.25 41 121422 167194 90339790
Live birth 113.05 30.25 295 121168 78812 90428172
Infusion related reaction 112.66 30.25 948 120515 415832 90091152
Blood pressure increased 112.58 30.25 62 121401 197155 90309829
White blood cell count decreased 111.80 30.25 42 121421 167067 90339917
Memory impairment 111.10 30.25 541 120922 196703 90310281
Atrial fibrillation 111.04 30.25 22 121441 133589 90373395
Alanine aminotransferase increased 110.70 30.25 14 121449 118324 90388660
Hypokalaemia 110.21 30.25 21 121442 131095 90375889
Cardiac failure 107.33 30.25 11 121452 109485 90397499
Hypoaesthesia 106.18 30.25 753 120710 313457 90193527
Renal impairment 104.88 30.25 10 121453 105411 90401573
Peripheral swelling 104.50 30.25 926 120537 412180 90094804
Influenza 103.75 30.25 29 121434 139235 90367749
Maternal exposure timing unspecified 103.70 30.25 139 121324 22344 90484640
Neuropathy peripheral 103.02 30.25 28 121435 136942 90370042
Knee arthroplasty 101.75 30.25 293 121170 82889 90424095
Weight increased 101.72 30.25 929 120534 416998 90089986
Alopecia 101.22 30.25 1061 120402 494010 90012974
Myositis 100.49 30.25 142 121321 23986 90482998
Sinusitis 99.46 30.25 793 120670 342295 90164689
Cerebrovascular accident 99.25 30.25 22 121441 123511 90383473
Aspartate aminotransferase increased 99.21 30.25 11 121452 102926 90404058
Myocardial infarction 98.01 30.25 13 121450 105959 90401025
Blood creatinine increased 97.29 30.25 11 121452 101375 90405609
Pleural effusion 96.14 30.25 17 121446 111974 90395010
Septic shock 95.49 30.25 4 121459 84156 90422828
Blood glucose increased 92.24 30.25 10 121453 95236 90411748
Asthma 89.89 30.25 594 120869 241566 90265418
Adverse event 89.71 30.25 353 121110 117065 90389919
Oxygen saturation decreased 88.68 30.25 18 121445 107465 90399519
Bradycardia 85.99 30.25 7 121456 83840 90423144
Muscle spasms 85.85 30.25 605 120858 251278 90255706
Deep vein thrombosis 85.31 30.25 11 121452 91609 90415375
Intentional overdose 83.31 30.25 13 121450 93821 90413163
Joint swelling 83.19 30.25 1035 120428 502265 90004719
Interstitial lung disease 82.34 30.25 5 121458 76400 90430584
Eye injury 82.07 30.25 87 121376 10933 90496051
Loss of consciousness 81.61 30.25 43 121420 140195 90366789
Inappropriate schedule of product administration 81.49 30.25 50 121413 149883 90357101
Retinitis 79.75 30.25 166 121297 38292 90468692
Bone erosion 78.09 30.25 200 121263 52821 90454163
Infection 77.72 30.25 784 120679 361310 90145674
Electrocardiogram QT prolonged 77.31 30.25 5 121458 72451 90434533
Influenza like illness 76.71 30.25 9 121454 80602 90426382
Suicidal ideation 76.20 30.25 6 121457 73849 90433135
Lupus-like syndrome 75.85 30.25 188 121275 48658 90458326
Anaphylactic reaction 75.75 30.25 13 121450 87511 90419473
Haematochezia 75.35 30.25 5 121458 70908 90436076
Overdose 74.65 30.25 61 121402 157648 90349336
Heart rate increased 74.47 30.25 29 121434 112873 90394111
Hypoxia 74.37 30.25 6 121457 72393 90434591
Dyspnoea exertional 74.23 30.25 6 121457 72282 90434702
Drug tolerance decreased 74.15 30.25 145 121318 31985 90474999
Thrombocytopenia 73.96 30.25 103 121360 208622 90298362
Herpes zoster 73.75 30.25 18 121445 94626 90412358
Abdominal discomfort 73.53 30.25 969 120494 476359 90030625
Tachycardia 73.38 30.25 62 121401 157611 90349373
Swollen joint count 72.91 30.25 73 121390 8580 90498404
Swelling face 72.84 30.25 11 121452 81341 90425643
Gastrointestinal haemorrhage 72.63 30.25 16 121447 90232 90416752
Hallucination 72.05 30.25 4 121459 65955 90441029
Colitis 71.28 30.25 6 121457 69936 90437048
Cardiac failure congestive 70.86 30.25 22 121441 98672 90408312
Flushing 70.59 30.25 16 121447 88475 90418509
Blood pressure decreased 69.71 30.25 9 121454 74886 90432098
Paraesthesia 69.44 30.25 573 120890 249753 90257231
Anti-cyclic citrullinated peptide antibody 69.18 30.25 128 121335 27093 90479891
Nasal congestion 68.75 30.25 14 121449 83400 90423584
Prescribed underdose 68.57 30.25 239 121224 74780 90432204
Stress 68.47 30.25 13 121450 81382 90425602
Agitation 67.71 30.25 6 121457 67092 90439892
Injection site erythema 67.15 30.25 24 121439 98478 90408506
Pulmonary oedema 67.09 30.25 4 121459 62076 90444908
Disability 65.58 30.25 159 121304 40586 90466398
Cardio-respiratory arrest 65.50 30.25 5 121458 63135 90443849
Vision blurred 65.39 30.25 33 121430 110260 90396724
Oropharyngeal pain 64.58 30.25 37 121426 115150 90391834
Headache 64.38 30.25 794 120669 861952 89645032
Abdominal distension 63.72 30.25 49 121414 130552 90376432
Rhinorrhoea 62.84 30.25 20 121443 88296 90418688
Cellulitis 62.69 30.25 22 121441 91315 90415669
Diabetes mellitus 62.34 30.25 7 121456 64868 90442116
Injection site reaction 61.81 30.25 23 121440 92057 90414927
Neutrophil count decreased 61.08 30.25 11 121452 71521 90435463
Nail disorder 60.01 30.25 195 121268 58872 90448112
Chronic obstructive pulmonary disease 59.59 30.25 13 121450 73816 90433168
Laryngitis 59.39 30.25 176 121287 50577 90456407
Skin exfoliation 58.96 30.25 10 121453 67903 90439081
Cholelithiasis 57.92 30.25 3 121460 52503 90454481
Lethargy 57.78 30.25 8 121455 63131 90443853
Dysphonia 57.71 30.25 8 121455 63076 90443908
Vertigo 56.95 30.25 12 121451 69799 90437185
Liver function test abnormal 55.79 30.25 3 121460 50842 90456142
Dyspepsia 55.69 30.25 455 121008 197705 90309279
Fatigue 55.04 30.25 1155 120308 1152868 89354116
Thrombosis 55.02 30.25 15 121448 73236 90433748
Dry skin 54.27 30.25 25 121438 88048 90418936
Exostosis 53.60 30.25 175 121288 52959 90454025
Incorrect dose administered 52.50 30.25 20 121443 78910 90428074
Blood alkaline phosphatase increased 52.25 30.25 3 121460 48076 90458908
Productive cough 52.14 30.25 19 121444 77044 90429940
Intentional product use issue 52.08 30.25 481 120982 216411 90290573
Injection site bruising 51.92 30.25 5 121458 52302 90454682
Blood potassium decreased 51.80 30.25 3 121460 47724 90459260
Bronchitis 51.67 30.25 78 121385 152849 90354135
Injection site swelling 51.53 30.25 9 121454 59830 90447154
Wrong technique in product usage process 51.29 30.25 16 121447 71555 90435429
Epistaxis 51.17 30.25 25 121438 85100 90421884
Rhabdomyolysis 50.61 30.25 5 121458 51251 90455733
Hepatitis 50.36 30.25 16 121447 70723 90436261
Cardiac disorder 50.21 30.25 8 121455 56864 90450120
Frequent bowel movements 49.97 30.25 179 121284 56756 90450228
Hepatic cirrhosis 49.78 30.25 192 121271 63061 90443923
Dysarthria 49.62 30.25 7 121456 54475 90452509
Hepatotoxicity 49.40 30.25 3 121460 45839 90461145
Hypothyroidism 47.98 30.25 7 121456 53120 90453864
Illness 47.88 30.25 25 121438 81944 90425040
Eczema 47.67 30.25 7 121456 52863 90454121
Maternal exposure during pregnancy 47.33 30.25 711 120752 359352 90147632
Therapeutic product effect incomplete 47.23 30.25 120 121343 193776 90313208
Pneumonia 47.21 30.25 588 120875 637471 89869513
Skin ulcer 46.64 30.25 6 121457 50069 90456915
Decreased appetite 46.61 30.25 736 120727 375804 90131180
Breast cancer 46.49 30.25 8 121455 53753 90453231
Hypoglycaemia 45.96 30.25 18 121445 69830 90437154
Rash erythematous 45.86 30.25 15 121448 65089 90441895
Hyperglycaemia 45.38 30.25 7 121456 50963 90456021
Hypocalcaemia 44.97 30.25 3 121460 42365 90464619
Throat irritation 44.96 30.25 6 121457 48689 90458295
Colitis ulcerative 44.25 30.25 179 121284 60087 90446897
Pain in jaw 44.09 30.25 6 121457 47979 90459005
Burning sensation 44.03 30.25 15 121448 63437 90443547
Adverse drug reaction 43.69 30.25 287 121176 116414 90390570
Cataract 43.59 30.25 21 121442 72071 90434913
Speech disorder 43.59 30.25 5 121458 45580 90461404
Rash maculo-papular 43.15 30.25 3 121460 40930 90466054
Nephrolithiasis 43.12 30.25 7 121456 49078 90457906
Cystitis 42.59 30.25 18 121445 66700 90440284
Fungal infection 42.55 30.25 4 121459 42657 90464327
Mental status changes 42.48 30.25 5 121458 44674 90462310
Pulmonary hypertension 42.38 30.25 4 121459 42519 90464465
Depressed mood 42.29 30.25 8 121455 50214 90456770
Arrhythmia 42.14 30.25 4 121459 42328 90464656
Pneumonitis 41.85 30.25 5 121458 44165 90462819
Unevaluable event 41.63 30.25 11 121452 54837 90452147
Medication error 41.20 30.25 223 121240 84429 90422555
Respiratory disorder 41.01 30.25 184 121279 64632 90442352
Multiple sclerosis relapse 40.64 30.25 10 121453 52295 90454689
Respiratory distress 40.64 30.25 3 121460 38943 90468041
Device expulsion 40.34 30.25 4 121459 40882 90466102
Acute respiratory failure 40.32 30.25 5 121458 42913 90464071
Aphasia 40.19 30.25 5 121458 42807 90464177
Staphylococcal infection 40.18 30.25 8 121455 48431 90458553
Upper respiratory tract infection 40.01 30.25 69 121394 128249 90378735
Neoplasm progression 39.86 30.25 6 121457 44480 90462504
Dry eye 39.68 30.25 14 121449 57917 90449067
Blood pressure fluctuation 38.87 30.25 11 121452 52402 90454582
Injection site pruritus 38.64 30.25 12 121451 53822 90453162
Viral infection 38.48 30.25 5 121458 41409 90465575
Taste disorder 38.40 30.25 174 121289 61372 90445612
Tinnitus 38.19 30.25 6 121457 43096 90463888
Drug ineffective for unapproved indication 37.94 30.25 21 121442 66623 90440361
Creatinine renal clearance increased 37.91 30.25 33 121430 3248 90503736
Drug hypersensitivity 37.91 30.25 850 120613 462759 90044225
Sleep disorder due to a general medical condition 37.86 30.25 139 121324 44599 90462385
Blepharospasm 37.82 30.25 161 121302 55284 90451700
Lip swelling 37.52 30.25 4 121459 38606 90468378
Cholestasis 37.30 30.25 3 121460 36296 90470688
Hypertension 36.83 30.25 837 120626 456695 90050289
Gastritis 36.57 30.25 6 121457 41747 90465237
Haemorrhage 36.49 30.25 24 121439 69345 90437639
Blood bilirubin increased 36.44 30.25 7 121456 43463 90463521
Disease recurrence 36.33 30.25 4 121459 37649 90469335
Therapy interrupted 36.27 30.25 11 121452 50097 90456887
Transaminases increased 35.76 30.25 4 121459 37188 90469796
Lymphocyte count decreased 35.73 30.25 3 121460 35047 90471937
Haematoma 35.60 30.25 5 121458 39043 90467941
Cerebral haemorrhage 35.07 30.25 3 121460 34519 90472465
Chronic kidney disease 34.60 30.25 12 121451 50179 90456805
Hypersensitivity 34.50 30.25 825 120638 453852 90053132
Blood creatine phosphokinase increased 34.44 30.25 3 121460 34020 90472964
Macular degeneration 34.30 30.25 5 121458 37965 90469019
Hepatic enzyme 34.26 30.25 39 121424 5305 90501679
Dysuria 33.77 30.25 6 121457 39395 90467589
Respiratory arrest 33.55 30.25 3 121460 33308 90473676
Eye pain 33.25 30.25 9 121454 44159 90462825
Hepatic steatosis 33.06 30.25 5 121458 36940 90470044
Hypocholesterolaemia 33.05 30.25 42 121421 6407 90500577
Generalised tonic-clonic seizure 32.95 30.25 4 121459 34899 90472085
Melaena 32.82 30.25 4 121459 34793 90472191
Weight fluctuation 32.78 30.25 78 121385 19671 90487313
Haematocrit decreased 32.50 30.25 8 121455 41824 90465160
Renal function test abnormal 32.46 30.25 44 121419 7147 90499837
Surgery 32.23 30.25 10 121453 44877 90462107
Hypercalcaemia 32.14 30.25 4 121459 34236 90472748
Bone pain 31.86 30.25 22 121441 61961 90445023
Incorrect route of product administration 31.49 30.25 143 121320 50483 90456501
Lymphadenopathy 31.45 30.25 11 121452 45764 90461220
Neuralgia 31.29 30.25 3 121460 31497 90475487
Treatment failure 31.02 30.25 576 120887 303352 90203632
Dysgeusia 30.74 30.25 16 121447 52544 90454440
Full blood count abnormal 30.45 30.25 6 121457 36591 90470393
Dyskinesia 30.38 30.25 6 121457 36528 90470456
Mouth ulceration 30.37 30.25 8 121455 39966 90467018
Transient ischaemic attack 30.32 30.25 10 121453 43166 90463818
Multiple drug therapy 30.30 30.25 42 121421 6967 90500017

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Milk-alkali syndrome 94.48 19.40 21 5190 686 42615438
Fatigue 43.53 19.40 134 5077 435507 42180617
Metabolic alkalosis 38.29 19.40 13 5198 2088 42614036
Hypercalcaemia 35.52 19.40 24 5187 18034 42598090
Psoriasis 27.88 19.40 32 5179 48572 42567552
Sleep disorder due to a general medical condition 24.71 19.40 19 5192 17434 42598690
Myalgia 22.08 19.40 41 5170 96039 42520085
Productive cough 21.61 19.40 29 5182 51538 42564586
HLA marker study positive 21.51 19.40 5 5206 200 42615924

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip dry 745.88 30.53 692 110239 99391 110378977
Muscle injury 721.83 30.53 795 110136 140012 110338356
Mobility decreased 671.29 30.53 997 109934 236425 110241943
Duodenal ulcer perforation 628.46 30.53 831 110100 176869 110301499
Deep vein thrombosis postoperative 627.02 30.53 501 110430 58790 110419578
Liver injury 621.36 30.53 760 110171 149653 110328715
Creatinine renal clearance decreased 609.56 30.53 338 110593 21477 110456891
Helicobacter infection 602.69 30.53 824 110107 181053 110297315
Sedation complication 600.04 30.53 324 110607 19531 110458837
Lower limb fracture 576.83 30.53 529 110402 74819 110403549
Anti-cyclic citrullinated peptide antibody positive 576.77 30.53 807 110124 181177 110297191
Autoimmune disorder 573.29 30.53 496 110435 64987 110413381
Pemphigus 567.99 30.53 874 110057 213696 110264672
Joint range of motion decreased 554.76 30.53 647 110284 121185 110357183
Irritable bowel syndrome 541.00 30.53 742 110189 163473 110314895
Folliculitis 539.52 30.53 749 110182 166904 110311464
Pericarditis 517.19 30.53 847 110084 218267 110260101
Psoriatic arthropathy 511.63 30.53 795 110136 195966 110282402
Peripheral venous disease 510.87 30.53 520 110411 83597 110394771
Hand deformity 508.12 30.53 839 110092 217667 110260701
Fibromyalgia 504.86 30.53 733 110198 170176 110308192
Lower respiratory tract infection 502.78 30.53 886 110045 242220 110236148
Night sweats 502.23 30.53 645 110286 133338 110345030
Rheumatoid factor positive 501.75 30.53 639 110292 131001 110347367
Bursitis 492.58 30.53 629 110302 129289 110349079
C-reactive protein abnormal 487.13 30.53 625 110306 129070 110349298
Type 2 diabetes mellitus 483.12 30.53 732 110199 176500 110301868
Discomfort 482.62 30.53 812 110119 213895 110264473
Blood cholesterol increased 465.64 30.53 736 110195 184049 110294319
Swollen joint count increased 462.83 30.53 492 110439 83169 110395199
Blood calcium decreased 457.99 30.53 339 110592 35506 110442862
Glossodynia 451.12 30.53 803 110128 221201 110257167
Impaired healing 440.77 30.53 743 110188 195974 110282394
Facet joint syndrome 438.67 30.53 513 110418 96315 110382053
Obesity 434.72 30.53 552 110379 112799 110365569
Osteoarthritis 424.14 30.53 701 110230 181922 110296446
Injury 423.25 30.53 689 110242 176576 110301792
Musculoskeletal pain 420.32 30.53 699 110232 182324 110296044
Adjustment disorder with depressed mood 418.03 30.53 349 110582 43534 110434834
Blister 415.98 30.53 786 110145 226590 110251778
Rheumatic fever 415.88 30.53 562 110369 122017 110356351
Acute kidney injury 405.48 30.53 74 110857 635356 109843012
Systemic lupus erythematosus 398.66 30.53 824 110107 253514 110224854
Breast cancer stage III 397.00 30.53 442 110489 78675 110399693
Sleep disorder due to general medical condition, insomnia type 396.48 30.53 509 110422 105134 110373234
Wound 395.36 30.53 783 110148 233654 110244714
Lung disorder 388.73 30.53 669 110262 179378 110298990
Road traffic accident 385.18 30.53 506 110425 106892 110371476
Stomatitis 372.40 30.53 831 110100 269411 110208957
Orthostatic hypotension 361.78 30.53 387 110544 65862 110412506
Wound infection 360.75 30.53 464 110467 96001 110382367
X-ray abnormal 360.69 30.53 302 110629 37815 110440553
Arthropathy 357.48 30.53 849 110082 286673 110191695
Oedema 342.81 30.53 692 110239 209284 110269084
Cognitive disorder 322.62 30.53 418 110513 87093 110391275
Sedation 320.24 30.53 372 110559 69311 110409057
Dislocation of vertebra 319.09 30.53 299 110632 43422 110434946
Dry mouth 318.13 30.53 652 110279 199296 110279072
Anaemia 317.65 30.53 79 110852 547007 109931361
Sciatica 316.94 30.53 426 110505 91973 110386395
Wheezing 294.03 30.53 732 110199 254498 110223870
Synovitis 292.84 30.53 764 110167 273328 110205040
Alopecia 290.95 30.53 915 110016 363838 110114530
Liver disorder 290.62 30.53 516 110415 141727 110336641
C-reactive protein 284.25 30.53 239 110692 30092 110448276
Lupus vulgaris 283.06 30.53 250 110681 33633 110444735
Urticaria 274.88 30.53 822 110109 318035 110160333
Death 274.81 30.53 182 110749 698687 109779681
Contusion 274.81 30.53 675 110256 232686 110245682
Gait inability 271.28 30.53 489 110442 135887 110342481
Prescribed overdose 269.17 30.53 383 110548 87198 110391170
Drug ineffective 268.48 30.53 719 110212 1519821 108958547
Febrile neutropenia 260.45 30.53 14 110917 316753 110161615
Hepatic enzyme increased 259.54 30.53 809 110122 320083 110158285
Pulmonary fibrosis 258.96 30.53 408 110523 101634 110376734
Neutropenia 258.22 30.53 35 110896 374585 110103783
Ill-defined disorder 245.31 30.53 508 110423 156345 110322023
Balance disorder 236.98 30.53 422 110509 116138 110362230
Abdominal pain upper 228.87 30.53 820 110111 348291 110130077
Rheumatoid arthritis 224.60 30.53 736 110195 298877 110179491
Swelling 218.68 30.53 811 110120 350230 110128138
Inflammation 214.88 30.53 547 110384 192691 110285677
Porphyria acute 214.17 30.53 166 110765 18614 110459754
Drug interaction 205.05 30.53 124 110807 500059 109978309
Hip arthroplasty 204.72 30.53 266 110665 55547 110422821
Sepsis 204.52 30.53 40 110891 327306 110151062
Maternal exposure during pregnancy 201.75 30.53 638 110293 254245 110224123
Pregnancy 197.71 30.53 250 110681 50817 110427551
Gastrointestinal disorder 196.43 30.53 611 110320 241341 110237027
Erythema 192.09 30.53 31 110900 291416 110186952
Musculoskeletal stiffness 189.08 30.53 664 110267 279158 110199210
Hypercholesterolaemia 184.78 30.53 329 110602 90508 110387860
Abdominal discomfort 184.33 30.53 833 110098 393025 110085343
Joint swelling 183.49 30.53 904 110027 441941 110036427
Renal failure 183.17 30.53 11 110920 226563 110251805
Amnesia 180.99 30.53 355 110576 105053 110373315
Live birth 177.88 30.53 279 110652 69205 110409163
Cough 177.53 30.53 123 110808 461518 110016850
Nasopharyngitis 175.61 30.53 822 110109 393539 110084829
Infusion related reaction 175.26 30.53 802 110129 380360 110098008
Migraine 174.55 30.53 470 110461 171182 110307186
Somnolence 172.37 30.53 43 110888 297406 110180962
Breast cancer stage II 171.14 30.53 172 110759 27203 110451165
Respiratory failure 169.50 30.53 12 110919 215320 110263048
Therapy non-responder 168.34 30.53 439 110492 156868 110321500
Cardiac arrest 167.15 30.53 7 110924 196746 110281622
Sleep disorder 165.24 30.53 506 110425 198138 110280230
Peripheral swelling 161.11 30.53 816 110115 403218 110075150
Muscle spasms 155.38 30.53 621 110310 277536 110200832
Grip strength decreased 154.93 30.53 284 110647 79890 110398478
Off label use 154.48 30.53 880 110051 1499305 108979063
Pancytopenia 153.22 30.53 16 110915 209597 110268771
Grip strength 152.94 30.53 102 110829 9039 110469329
Ulcer haemorrhage 152.58 30.53 148 110783 22423 110455945
Hypoaesthesia 151.76 30.53 671 110260 313552 110164816
Depressed level of consciousness 150.74 30.53 342 110589 111936 110366432
Memory impairment 146.73 30.53 483 110448 196461 110281907
Maternal exposure timing unspecified 146.22 30.53 140 110791 20873 110457495
Sinusitis 145.89 30.53 637 110294 296051 110182317
Disease progression 143.87 30.53 34 110897 244000 110234368
Lupus-like syndrome 142.75 30.53 190 110741 40602 110437766
Seizure 142.46 30.53 25 110906 221160 110257208
Asthma 142.36 30.53 562 110369 249729 110228639
Dehydration 141.00 30.53 52 110879 279459 110198909
Retinitis 140.87 30.53 168 110763 32159 110446209
Knee arthroplasty 140.86 30.53 242 110689 64706 110413662
Bone erosion 138.33 30.53 200 110731 46171 110432197
COVID-19 137.07 30.53 38 110893 245022 110233346
Renal impairment 136.16 30.53 15 110916 188430 110289938
Cardiac failure 135.40 30.53 15 110916 187611 110290757
Walking aid user 134.23 30.53 145 110786 24930 110453438
Platelet count decreased 134.10 30.53 33 110898 230410 110247958
Alanine aminotransferase increased 131.84 30.53 15 110916 183758 110294610
Weight increased 130.80 30.53 793 110138 418851 110059517
Adverse event 129.27 30.53 316 110615 108493 110369875
Haemoglobin decreased 127.61 30.53 45 110886 248682 110229686
Hyponatraemia 126.97 30.53 31 110900 217622 110260746
Pulmonary embolism 126.19 30.53 30 110901 214444 110263924
Urinary tract infection 123.96 30.53 88 110843 326194 110152174
Multiple organ dysfunction syndrome 123.72 30.53 7 110924 151703 110326665
Hyperkalaemia 121.85 30.53 3 110928 135793 110342575
Back pain 121.22 30.53 116 110815 370880 110107488
Septic shock 120.51 30.53 10 110921 157518 110320850
Paraesthesia 120.49 30.53 573 110358 275948 110202420
Product dose omission issue 119.36 30.53 89 110842 321693 110156675
Confusional state 118.87 30.53 841 110090 467839 110010529
Syncope 117.84 30.53 29 110902 202507 110275861
Laryngitis 116.54 30.53 176 110755 42235 110436133
Bradycardia 115.92 30.53 11 110920 155506 110322862
Atrial fibrillation 115.34 30.53 43 110888 229599 110248769
Infection 114.45 30.53 687 110244 361513 110116855
Tremor 113.76 30.53 31 110900 202201 110276167
General physical health deterioration 113.04 30.53 772 110159 424523 110053845
Myocardial infarction 112.74 30.53 27 110904 192056 110286312
Aspartate aminotransferase increased 109.98 30.53 15 110916 159921 110318447
Malignant neoplasm progression 109.68 30.53 21 110910 174546 110303822
Dysphagia 109.02 30.53 13 110918 153587 110324781
Interstitial lung disease 108.96 30.53 8 110923 139326 110339042
Delirium 106.73 30.53 338 110593 134687 110343681
Prescribed underdose 106.43 30.53 215 110716 64959 110413409
Nausea 105.86 30.53 766 110165 1234924 109243444
White blood cell count decreased 105.46 30.53 49 110882 229341 110249027
Thrombocytopenia 103.92 30.53 118 110813 348767 110129601
Exostosis 103.29 30.53 174 110757 45782 110432586
Blood creatinine increased 101.07 30.53 29 110902 182860 110295508
Nail disorder 100.48 30.53 196 110735 57739 110420629
Hyperhidrosis 99.35 30.53 32 110899 187266 110291102
Drug tolerance decreased 99.02 30.53 130 110801 27410 110450958
Chest discomfort 99.00 30.53 26 110905 173822 110304546
Pneumonia 98.32 30.53 499 110432 876215 109602153
Hypokalaemia 97.07 30.53 31 110900 182417 110295951
Anti-cyclic citrullinated peptide antibody 95.74 30.53 109 110822 19855 110458513
Cerebrovascular accident 94.35 30.53 32 110899 181252 110297116
Pleural effusion 93.13 30.53 31 110900 177678 110300690
Oxygen saturation decreased 92.25 30.53 22 110909 156960 110321408
Hypoxia 91.82 30.53 11 110920 129504 110348864
Swollen joint count 90.99 30.53 73 110858 8601 110469767
Chills 90.28 30.53 39 110892 190541 110287827
Hypersensitivity 89.90 30.53 703 110228 403295 110075073
Agitation 89.82 30.53 6 110925 113045 110365323
Intentional overdose 89.75 30.53 13 110918 132488 110345880
Palpitations 88.43 30.53 25 110906 159187 110319181
Gastrointestinal haemorrhage 88.28 30.53 28 110903 165490 110312878
Chest pain 88.25 30.53 663 110268 375712 110102656
Metabolic acidosis 86.57 30.53 3 110928 99741 110378627
Electrocardiogram QT prolonged 85.93 30.53 6 110925 108954 110369414
Injection site pain 84.93 30.53 36 110895 177886 110300482
Feeling abnormal 83.99 30.53 38 110893 180673 110297695
Subcutaneous drug absorption impaired 83.64 30.53 66 110865 7593 110470775
Mucosal inflammation 83.07 30.53 3 110928 96138 110382230
Hallucination 81.72 30.53 5 110926 101427 110376941
Deep vein thrombosis 81.42 30.53 20 110911 139867 110338501
Influenza 81.06 30.53 34 110897 169067 110309301
Loss of consciousness 79.86 30.53 49 110882 196257 110282111
Lactic acidosis 79.83 30.53 3 110928 92808 110385560
Neutrophil count decreased 79.33 30.53 13 110918 120928 110357440
Coma 78.83 30.53 12 110919 117857 110360511
Overdose 78.80 30.53 71 110860 233723 110244645
Cardiac failure congestive 77.97 30.53 27 110904 150973 110327395
Hepatic cirrhosis 76.71 30.53 193 110738 67433 110410935
Blood pressure decreased 76.33 30.53 12 110919 115079 110363289
Adverse drug reaction 75.99 30.53 256 110675 105303 110373065
Drug abuse 75.40 30.53 42 110889 177369 110300999
Pulmonary oedema 75.33 30.53 7 110924 100652 110377716
Inappropriate schedule of product administration 74.61 30.53 57 110874 203580 110274788
Haematochezia 74.49 30.53 13 110918 115511 110362857
Diabetes mellitus 74.13 30.53 7 110924 99374 110378994
Foot deformity 73.36 30.53 155 110776 48325 110430043
Blood glucose increased 73.21 30.53 21 110910 132475 110345893
Blood pressure increased 73.06 30.53 91 110840 258282 110220086
Rhabdomyolysis 72.48 30.53 16 110915 120385 110357983
Treatment failure 72.23 30.53 501 110430 276733 110201635
Stress 72.14 30.53 10 110921 105338 110373030
Neuropathy peripheral 69.84 30.53 47 110884 179230 110299138
Tachycardia 69.28 30.53 75 110856 226570 110251798
Anaphylactic reaction 69.19 30.53 15 110916 114285 110364083
Sleep disorder due to a general medical condition 69.09 30.53 158 110773 51954 110426414
Suicidal ideation 69.06 30.53 7 110924 93930 110384438
Blepharospasm 66.94 30.53 161 110770 54690 110423678
Therapeutic product effect decreased 66.91 30.53 447 110484 243869 110234499
Cardio-respiratory arrest 66.56 30.53 17 110914 115819 110362549
Dyspnoea exertional 66.46 30.53 12 110919 104048 110374320
Colitis 64.92 30.53 12 110919 102311 110376057
Intentional product use issue 63.39 30.53 446 110485 247460 110230908
Hypoglycaemia 63.06 30.53 19 110912 116085 110362283
Respiratory disorder 62.27 30.53 185 110746 71197 110407171
Frequent bowel movements 62.25 30.53 185 110746 71205 110407163
Abdominal distension 61.65 30.53 51 110880 175052 110303316
Chronic obstructive pulmonary disease 60.87 30.53 17 110914 109141 110369227
Dyspepsia 60.73 30.53 363 110568 190602 110287766
Thrombosis 60.45 30.53 17 110914 108645 110369723
Swelling face 60.38 30.53 10 110921 92311 110386057
Flushing 58.98 30.53 16 110915 104720 110373648
Heart rate increased 58.36 30.53 36 110895 143798 110334570
Mental status changes 57.75 30.53 5 110926 76117 110402251
Dysarthria 57.56 30.53 8 110923 84113 110394255
Taste disorder 57.55 30.53 170 110761 65217 110413151
Lethargy 57.21 30.53 12 110919 93564 110384804
Influenza like illness 56.89 30.53 10 110921 88402 110389966
Herpes zoster 56.61 30.53 19 110912 108360 110370008
Contraindicated product administered 55.70 30.53 433 110498 247834 110230534
Blood alkaline phosphatase increased 55.66 30.53 4 110927 70931 110407437
Back disorder 54.90 30.53 85 110846 20837 110457531
Cellulitis 54.75 30.53 29 110902 125987 110352381
Ascites 54.53 30.53 13 110918 92795 110385573
Acute respiratory failure 54.32 30.53 6 110925 75254 110403114
Drug hypersensitivity 53.57 30.53 693 110238 453397 110024971
Colitis ulcerative 53.38 30.53 185 110746 77178 110401190
Hypocalcaemia 53.33 30.53 3 110928 65363 110413005
Joint dislocation 52.52 30.53 110 110821 34080 110444288
Ear infection 52.28 30.53 160 110771 62572 110415796
Pustular psoriasis 51.68 30.53 66 110865 13539 110464829
Myalgia 51.46 30.53 90 110841 222291 110256077
Hepatotoxicity 51.45 30.53 3 110928 63397 110414971
Liver function test abnormal 51.05 30.53 5 110926 68945 110409423
Respiratory distress 50.98 30.53 5 110926 68869 110409499
Rash maculo-papular 50.92 30.53 7 110924 74215 110404153
General symptom 50.61 30.53 53 110878 8793 110469575
Pneumonia aspiration 50.53 30.53 10 110921 81223 110397145
Cholestasis 49.60 30.53 4 110927 64514 110413854
Gamma-glutamyltransferase increased 49.45 30.53 3 110928 61306 110417062
Incorrect dose administered 49.40 30.53 21 110910 103620 110374748
Eczema 49.17 30.53 7 110924 72286 110406082
Transaminases increased 48.54 30.53 4 110927 63386 110414982
Skin exfoliation 48.22 30.53 14 110917 87637 110390731
Wrong technique in product usage process 47.97 30.53 14 110917 87334 110391034
Hyperglycaemia 47.91 30.53 13 110918 85077 110393291
Rash vesicular 47.84 30.53 66 110865 14586 110463782
Vertigo 47.56 30.53 14 110917 86856 110391512
Cerebral haemorrhage 47.35 30.53 5 110926 64963 110413405
Haemorrhage 47.17 30.53 24 110907 106668 110371700
Eye injury 47.14 30.53 48 110883 7707 110470661
Epistaxis 47.10 30.53 37 110894 130335 110348033
Laboratory test abnormal 47.09 30.53 123 110808 43956 110434412
Arrhythmia 46.71 30.53 7 110924 69568 110408800
Medication error 46.30 30.53 219 110712 105147 110373221
Disability 46.15 30.53 97 110834 30126 110448242
Drug ineffective for unapproved indication 45.67 30.53 23 110908 102815 110375553
Creatinine renal clearance increased 45.65 30.53 34 110897 3591 110474777
Blood creatine phosphokinase increased 45.45 30.53 9 110922 73068 110405300
Acute myocardial infarction 44.97 30.53 14 110917 83763 110394605
Hepatitis 44.96 30.53 17 110914 90037 110388331
Hepatic enzyme 44.92 30.53 39 110892 5124 110473244
Weight fluctuation 44.74 30.53 80 110851 22065 110456303
Oropharyngeal pain 44.48 30.53 42 110889 135234 110343134
Pneumonitis 44.42 30.53 11 110920 76520 110401848
Drug intolerance 44.04 30.53 611 110320 405901 110072467
Respiratory arrest 43.76 30.53 4 110927 58295 110420073
Pulmonary hypertension 43.66 30.53 3 110928 55217 110423151
Pancreatitis acute 43.01 30.53 5 110926 60269 110418099
Leukocytosis 42.34 30.53 3 110928 53825 110424543
Blood bilirubin increased 42.04 30.53 12 110919 75960 110402408
Speech disorder 41.78 30.53 6 110925 61563 110416805
Intestinal obstruction 41.77 30.53 3 110928 53224 110425144
Skin ulcer 41.38 30.53 7 110924 63638 110414730
Hypocholesterolaemia 41.33 30.53 41 110890 6380 110471988
Hypothyroidism 41.31 30.53 11 110920 72888 110405480
Hypophagia 41.20 30.53 3 110928 52623 110425745
Dry skin 40.89 30.53 29 110902 107624 110370744
Nasal congestion 40.70 30.53 24 110907 98258 110380110
Staphylococcal infection 40.69 30.53 10 110921 69934 110408434
Cardiac disorder 40.49 30.53 13 110918 76267 110402101
Coronary artery disease 40.28 30.53 11 110920 71679 110406689
Lymphocyte count decreased 40.23 30.53 5 110926 57238 110421130
Tubulointerstitial nephritis 40.02 30.53 4 110927 54280 110424088
Rhinorrhoea 39.86 30.53 27 110904 102639 110375729
Blood potassium decreased 39.86 30.53 4 110927 54110 110424258
Psychotic disorder 39.60 30.53 3 110928 50934 110427434
Nephrolithiasis 39.44 30.53 9 110922 66203 110412165
Haematocrit decreased 39.36 30.53 9 110922 66108 110412260
Hypertension 39.19 30.53 724 110207 509360 109969008
Injection site erythema 39.00 30.53 23 110908 94153 110384215
Haematoma 38.99 30.53 6 110925 58470 110419898
Accidental exposure to product 38.72 30.53 3 110928 50005 110428363
Eosinophilia 38.50 30.53 6 110925 57930 110420438
Rash erythematous 38.34 30.53 17 110914 81815 110396553
Neoplasm progression 38.04 30.53 9 110922 64586 110413782
Melaena 37.79 30.53 11 110920 68746 110409622
Anaphylactic shock 37.48 30.53 4 110927 51542 110426826
Decreased appetite 37.46 30.53 678 110253 475168 110003200
Leukopenia 37.42 30.53 57 110874 148734 110329634
Neuralgia 37.28 30.53 3 110928 48475 110429893
Product prescribing error 37.28 30.53 4 110927 51327 110427041
Aphasia 37.25 30.53 7 110924 58990 110419378
Chronic kidney disease 37.10 30.53 15 110916 76276 110402092
Dysphonia 36.81 30.53 15 110916 75914 110402454
Fungal infection 36.79 30.53 4 110927 50802 110427566
Lip swelling 36.67 30.53 4 110927 50663 110427705
Irritability 36.65 30.53 3 110928 47806 110430562
Blood pressure fluctuation 35.92 30.53 15 110916 74809 110403559
Vision blurred 35.87 30.53 46 110885 128976 110349392
Pericardial effusion 35.68 30.53 7 110924 57210 110421158
Generalised tonic-clonic seizure 35.58 30.53 6 110925 54674 110423694
Multiple drug therapy 35.49 30.53 42 110889 7972 110470396
Jaundice 35.39 30.53 8 110923 59228 110419140
Product use issue 35.18 30.53 472 110459 311223 110167145
Injection site reaction 35.15 30.53 23 110908 89047 110389321
Cholelithiasis 35.13 30.53 10 110921 63412 110414956
Skin lesion 35.11 30.53 5 110926 51626 110426742
Pallor 35.02 30.53 7 110924 56460 110421908
Cataract 34.96 30.53 18 110913 79467 110398901
Renal function test abnormal 34.94 30.53 44 110887 8902 110469466
Incorrect route of product administration 34.88 30.53 142 110789 63919 110414449
Restlessness 34.83 30.53 7 110924 56252 110422116
Depressed mood 34.79 30.53 9 110922 60800 110417568
Hepatocellular injury 34.22 30.53 5 110926 50637 110427731
Epilepsy 34.12 30.53 194 110737 100015 110378353
Lymphadenopathy 33.67 30.53 11 110920 63824 110414544
Hypervolaemia 33.15 30.53 5 110926 49455 110428913
Ear pain 33.06 30.53 123 110808 53103 110425265
Feeling hot 32.76 30.53 179 110752 90927 110387441
Illness 32.73 30.53 21 110910 82150 110396218
Gastritis 32.59 30.53 7 110924 53692 110424676
Injection site bruising 32.54 30.53 6 110925 51257 110427111
Pain in jaw 32.47 30.53 6 110925 51171 110427197
Throat irritation 32.46 30.53 7 110924 53545 110424823
Blood urea increased 31.70 30.53 8 110923 54949 110423419
Bronchitis 31.60 30.53 69 110862 156963 110321405
Burning sensation 31.46 30.53 15 110916 69197 110409171
Dyspnoea 31.41 30.53 858 110073 1106014 109372354
Clostridium difficile infection 31.22 30.53 7 110924 52122 110426246

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AX05 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids

Related Drugs by ATC class:

M01AX Other antiinflammatory and antirheumatic agents, non-steroids 13 drugs
azapropazonebenzydaminechondroitin sulfatediacereinfeprazonemorniflumatenabumetoneniflumic acidnimesulideorgoteinoxaceprolproquazone show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Hypertensive disorder contraindication 38341003 DOID:10763
Hyperlipidemia contraindication 55822004 DOID:1168
Hypercalcemia contraindication 66931009 DOID:12678
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Arteriosclerosis obliterans contraindication 361133006 DOID:5160




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.28 acidic
pKa2 12.49 acidic
pKa3 14.0 acidic
pKa4 7.29 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021359 VUID
N0000148778 NUI
D04334 KEGG_DRUG
4021359 VANDF
C0017718 UMLSCUI
CHEBI:5417 CHEBI
CHEMBL493287 ChEMBL_ID
DB01296 DRUGBANK_ID
D005944 MESH_DESCRIPTOR_UI
439213 PUBCHEM_CID
3120 INN_ID
N08U5BOQ1K UNII
4845 RXNORM
19221 MMSL
d04418 MMSL
004563 NDDF
408111007 SNOMEDCT_US
70237008 SNOMEDCT_US
N08U5BOQ1K INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Remaxazon External Patch HUMAN PRESCRIPTION DRUG LABEL 4 69379-285 PATCH 5 g TOPICAL unapproved drug other 2 sections
Joint And Bone Cream HUMAN OTC DRUG LABEL 4 84660-013 CREAM 8.85 g TOPICAL OTC Monograph Drug 8 sections
XIMONTH Bee Venom Pain Cream HUMAN OTC DRUG LABEL 4 84660-033 CREAM 4.50 g TOPICAL OTC Monograph Drug 8 sections
SOUTH MOON Melittin Joint Soothing Gel HUMAN OTC DRUG LABEL 2 84732-055 GEL 1 mg CUTANEOUS OTC Monograph Drug 9 sections