niflumic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, anilinonicotinic acid derivatives 1925 4394-00-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niflumic acid
  • niflamol
  • nifluminic acid
An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
  • Molecular weight: 282.22
  • Formula: C13H9F3N2O2
  • CLOGP: 4.77
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 62.22
  • ALOGS: -3.50
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AX02 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Other antiinflammatory and antirheumatic agents, non-steroids
ATC M02AA17 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.74 acidic
pKa2 5.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Chloride channel protein ClC-Ka Ion channel ACTIVATOR EC50 5 IUPHAR
Prostaglandin G/H synthase 2 Enzyme IC50 6.04 DRUG MATRIX
Prostaglandin G/H synthase 1 Enzyme IC50 5.97 DRUG MATRIX
G-protein coupled receptor 35 GPCR Ki 5.44 CHEMBL
Chloride channel protein ClC-Kb Ion channel ACTIVATOR EC50 5 IUPHAR
Transthyretin Secreted Kd 6.59 CHEMBL
Potassium channel subfamily T member 2 Ion channel ACTIVATOR EC50 8.68 IUPHAR

External reference:

IDSource
N0000167326 NUI
C0028067 UMLSCUI
D08275 KEGG_DRUG
4U5MP5IUD8 UNII
2194 INN_ID
7418 RXNORM
005830 NDDF
CHEBI:34888 CHEBI
CHEMBL63323 ChEMBL_ID
DB04552 DRUGBANK_ID
4488 PUBCHEM_CID
D009544 MESH_DESCRIPTOR_UI
2439 IUPHAR_LIGAND_ID

Pharmaceutical products:

None