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niflumic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory, anilinonicotinic acid derivatives	1925	4394-00-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: niflumic acid niflamol nifluminic acid	An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. Molecular weight: 282.22 Formula: C13H9F3N2O2 CLOGP: 4.77 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 62.22 ALOGS: -3.50 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

niflumic acid
niflamol
nifluminic acid

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

Molecular weight: 282.22
Formula: C13H9F3N2O2
CLOGP: 4.77
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 62.22
ALOGS: -3.50
ROTB: 4

Drug dosage:

Dose	Unit	Route
0.75	g	O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Aspirin-exacerbated respiratory disease	69.17	53.47	9	96	1198	79743085

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	M01AX02	MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Other antiinflammatory and antirheumatic agents, non-steroids
ATC	M02AA17	MUSCULO-SKELETAL SYSTEM TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN Antiinflammatory preparations, non-steroids for topical use
MeSH PA	D000700	Analgesics
MeSH PA	D018712	Analgesics, Non-Narcotic
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000894	Anti-Inflammatory Agents, Non-Steroidal
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D016861	Cyclooxygenase Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D018373	Peripheral Nervous System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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🐶 Veterinary Drug Use

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🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.74	acidic
pKa2	5.54	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN		IC50	6.04	DRUG MATRIX
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	5.97	DRUG MATRIX
Dihydroorotate dehydrogenase (quinone), mitochondrial	Enzyme	Q02127	PYRD_HUMAN		IC50	4.77	CHEMBL
Transthyretin	Secreted	P02766	TTHY_HUMAN		Kd	6.59	CHEMBL
Chloride channel protein ClC-Ka	Ion channel	P51800	CLCKA_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Potassium channel subfamily T member 2	Ion channel	Q6UVM3	KCNT2_HUMAN	ACTIVATOR	EC50	8.68	IUPHAR
G-protein coupled receptor 35	GPCR	Q9HC97	GPR35_HUMAN		Ki	5.44	CHEMBL
Chloride channel protein ClC-Kb	Ion channel	P51801	CLCKB_HUMAN	ACTIVATOR	EC50	5	IUPHAR
Transcriptional enhancer factor TEF-3	Transcription factor	Q15561	TEAD4_HUMAN		Kd	4.55	CHEMBL
Transcription factor SOX-18	Unclassified		SOX18_MOUSE		IC50	4.30	CHEMBL

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External reference:

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ID	Source
005830	NDDF
2194	INN_ID
2439	IUPHAR_LIGAND_ID
4488	PUBCHEM_CID
4U5MP5IUD8	UNII
7418	RXNORM
C0028067	UMLSCUI
CHEBI:34888	CHEBI
CHEMBL63323	ChEMBL_ID
D009544	MESH_DESCRIPTOR_UI

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Pharmaceutical products:

None