fluconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 1187 86386-73-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluconazole
  • difluconazole
  • flunazol
  • diflucan
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
  • Molecular weight: 306.28
  • Formula: C13H12F2N6O
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.65
  • ALOGS: -2.34
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.75 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.31 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.89 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 15
kinase-selectivity-class GRK2 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 10.940 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.209 % High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 29, 1990 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 683.81 10.04 946 120275 157403 90349823
Drug interaction 529.40 10.04 1152 120069 275301 90231925
Thrombocytopenia 415.59 10.04 884 120337 207841 90299385
Candida infection 409.60 10.04 350 120871 33707 90473519
Pemphigus 386.44 10.04 11 121210 326853 90180373
Hand deformity 361.77 10.04 7 121214 296355 90210871
Mucosal inflammation 359.51 10.04 414 120807 57211 90450015
Systemic lupus erythematosus 352.75 10.04 37 121184 361859 90145367
Glossodynia 349.72 10.04 20 121201 321759 90185467
Synovitis 342.17 10.04 26 121195 329726 90177500
Food allergy 337.74 10.04 277 120944 25201 90482025
Cytokine release syndrome 293.37 10.04 266 120955 27707 90479519
Foetal death 282.45 10.04 229 120992 20494 90486732
Sepsis 279.61 10.04 691 120530 179123 90328103
Fungal infection 278.79 10.04 314 120907 42347 90464879
Wound 275.51 10.04 39 121182 302941 90204285
Immunodeficiency 268.61 10.04 310 120911 42924 90464302
Arthropathy 267.42 10.04 79 121142 366163 90141063
Pericarditis 259.65 10.04 29 121192 270122 90237104
Stevens-Johnson syndrome 252.08 10.04 250 120971 29126 90478100
Multiple organ dysfunction syndrome 251.78 10.04 379 120842 67957 90439269
Helicobacter infection 249.82 10.04 13 121208 226837 90280389
Temperature regulation disorder 248.60 10.04 184 121037 14395 90492831
Rash erythematous 246.91 10.04 366 120855 64738 90442488
Pancytopenia 246.82 10.04 516 120705 119747 90387479
Abdominal discomfort 240.46 10.04 173 121048 477155 90030071
Pyrexia 237.08 10.04 1602 119619 658883 89848343
Muscle injury 220.41 10.04 3 121218 176651 90330575
Therapeutic product effect decreased 211.65 10.04 55 121166 277516 90229710
Folliculitis 206.64 10.04 18 121203 204335 90302891
Cytomegalovirus infection 202.08 10.04 212 121009 26390 90480836
Swelling 198.09 10.04 162 121059 418896 90088330
Irritable bowel syndrome 197.47 10.04 23 121198 207425 90299801
Oral candidiasis 193.51 10.04 238 120983 35217 90472009
Impaired healing 193.31 10.04 39 121182 234160 90273066
Arthralgia 193.24 10.04 477 120744 778045 89729181
Mucormycosis 187.78 10.04 95 121126 3726 90503500
Alopecia 187.63 10.04 232 120989 494839 90012387
Platelet count decreased 186.63 10.04 501 120720 136468 90370758
Female genital tract fistula 185.56 10.04 169 121052 17699 90489527
Neutropenia 184.27 10.04 690 120531 224214 90283012
Septic shock 183.12 10.04 370 120851 83790 90423436
Completed suicide 178.67 10.04 3 121218 145055 90362171
Type 2 diabetes mellitus 173.78 10.04 31 121190 203213 90304013
Aspergillus infection 165.51 10.04 128 121093 10695 90496531
Fibromyalgia 164.80 10.04 37 121184 206232 90300994
Vaginal discharge 163.95 10.04 164 121057 19300 90487926
Graft versus host disease 162.27 10.04 113 121108 8031 90499195
Psoriatic arthropathy 156.38 10.04 55 121166 228280 90278946
Musculoskeletal stiffness 155.11 10.04 103 121118 296429 90210797
Aplastic anaemia 154.69 10.04 134 121087 13135 90494091
Maternal exposure during pregnancy 145.72 10.04 160 121061 359903 90147323
Chronic sinusitis 145.02 10.04 169 121052 23633 90483593
Drug resistance 134.29 10.04 184 121037 30265 90476961
Nasopharyngitis 133.95 10.04 211 121010 406893 90100333
Mobility decreased 129.89 10.04 88 121133 250646 90256580
Discomfort 129.60 10.04 106 121115 274229 90232997
Peripheral swelling 129.49 10.04 221 121000 412885 90094341
Disseminated mucormycosis 128.17 10.04 44 121177 627 90506599
Ill-defined disorder 125.79 10.04 45 121176 184846 90322380
Constipation 125.13 10.04 720 120501 279675 90227551
Pathogen resistance 124.14 10.04 96 121125 8019 90499207
Toxic epidermal necrolysis 123.48 10.04 183 121038 32345 90474881
Drug ineffective for unapproved indication 122.96 10.04 274 120947 66370 90440856
Swollen tongue 122.09 10.04 220 121001 45736 90461490
Neutrophil count decreased 121.90 10.04 285 120936 71247 90435979
Vaginal flatulence 120.53 10.04 114 121107 12524 90494702
Proctitis 120.18 10.04 124 121097 15135 90492091
Upper respiratory tract infection 119.77 10.04 411 120810 127907 90379319
Blood cholesterol increased 118.90 10.04 65 121156 207947 90299279
Anaemia 117.42 10.04 841 120380 351961 90155265
Lip dry 107.38 10.04 7 121214 100948 90406278
Deep vein thrombosis 103.20 10.04 313 120908 91307 90415919
Torsade de pointes 103.02 10.04 114 121107 15068 90492158
Joint range of motion decreased 101.21 10.04 28 121193 135615 90371611
Liver injury 100.87 10.04 51 121170 170516 90336710
Sinusitis fungal 99.95 10.04 50 121171 1914 90505312
C-reactive protein abnormal 99.48 10.04 24 121197 127405 90379821
Radiculopathy 99.00 10.04 123 121098 18382 90488844
Colitis 97.39 10.04 258 120963 69684 90437542
Intentional product misuse 97.09 10.04 302 120919 89302 90417924
Intentional product use issue 96.11 10.04 89 121132 216803 90290423
Erythema 95.35 10.04 578 120643 228668 90278558
Systemic candida 94.60 10.04 67 121154 4892 90502334
Gastrointestinal disorder 93.25 10.04 124 121097 256563 90250663
Abortion spontaneous 92.78 10.04 216 121005 53840 90453386
Contusion 92.65 10.04 120 121101 251096 90256130
Immune effector cell-associated neurotoxicity syndrome 92.10 10.04 70 121151 5698 90501528
Enterococcal infection 91.25 10.04 88 121133 9903 90497323
Immune reconstitution inflammatory syndrome 90.26 10.04 75 121146 6944 90500282
Fungaemia 89.92 10.04 56 121165 3294 90503932
Hypercholesterolaemia 89.29 10.04 14 121207 100878 90406348
Grip strength decreased 88.72 10.04 10 121211 92566 90414660
Drug reaction with eosinophilia and systemic symptoms 88.27 10.04 184 121037 42574 90464652
Swelling face 87.96 10.04 274 120947 81078 90426148
Fixed eruption 87.91 10.04 44 121177 1686 90505540
Cytomegalovirus viraemia 87.20 10.04 76 121145 7510 90499716
Bronchopulmonary aspergillosis 86.85 10.04 91 121130 11307 90495919
Peripheral venous disease 85.87 10.04 7 121214 83914 90423312
Salpingo-oophorectomy unilateral 85.01 10.04 36 121185 932 90506294
Night sweats 84.79 10.04 33 121188 128733 90378493
Fall 83.62 10.04 346 120875 481464 90025762
Hyperhidrosis 83.04 10.04 382 120839 135923 90371303
Acute myeloid leukaemia 82.51 10.04 119 121102 20521 90486705
Sleep disorder 82.27 10.04 86 121135 197944 90309282
Wound infection 81.20 10.04 21 121200 106381 90400845
Gait inability 80.48 10.04 48 121173 146408 90360818
Lower limb fracture 79.44 10.04 10 121211 85003 90422223
Acute kidney injury 78.86 10.04 713 120508 319674 90187552
Bacterial sepsis 78.83 10.04 60 121161 4895 90502331
Mouth ulceration 77.86 10.04 168 121053 39806 90467420
Respiratory failure 77.48 10.04 339 120882 118079 90389147
Live birth 77.19 10.04 8 121213 79099 90428127
General physical health deterioration 76.28 10.04 233 120988 354882 90152344
White blood cell count decreased 75.04 10.04 430 120791 166679 90340547
Road traffic accident 73.52 10.04 26 121195 107600 90399626
Pseudomonas infection 73.49 10.04 95 121126 14770 90492456
Plasma cell myeloma 73.22 10.04 166 121055 40662 90466564
Contraindicated product administered 73.15 10.04 204 121017 319935 90187291
Wheezing 73.03 10.04 129 121092 237951 90269275
Meningitis cryptococcal 71.36 10.04 39 121182 1794 90505432
Dysbiosis 71.25 10.04 38 121183 1664 90505562
Intentional overdose 70.69 10.04 19 121202 93815 90413411
Skin candida 70.44 10.04 38 121183 1703 90505523
Neutropenic sepsis 70.25 10.04 103 121118 18027 90489199
Pulmonary fibrosis 70.04 10.04 28 121193 107475 90399751
Oesophageal candidiasis 69.75 10.04 64 121157 6765 90500461
Weight increased 69.49 10.04 305 120916 417622 90089604
Inflammation 69.30 10.04 82 121139 178510 90328716
Sputum increased 68.39 10.04 45 121176 2912 90504314
Adverse event 68.08 10.04 36 121185 117382 90389844
Embolism venous 66.96 10.04 48 121173 3572 90503654
Blister 66.37 10.04 152 121069 254846 90252380
Acute graft versus host disease in skin 65.73 10.04 53 121168 4703 90502523
Lower respiratory tract infection 65.58 10.04 149 121072 250510 90256716
International normalised ratio increased 65.32 10.04 174 121047 47142 90460084
Blood lactate dehydrogenase increased 64.90 10.04 121 121100 25811 90481415
Dry mouth 64.72 10.04 91 121130 183968 90323258
Obesity 64.72 10.04 30 121191 105477 90401749
Dysphonia 64.10 10.04 208 121013 62876 90444350
Staphylococcal infection 63.73 10.04 175 121046 48264 90458962
Renal failure 63.39 10.04 344 120877 130663 90376563
Abdominal pain upper 63.38 10.04 230 120991 332444 90174782
Laryngitis fungal 62.36 10.04 19 121202 180 90507046
Joint swelling 62.18 10.04 406 120815 502894 90004332
Infective aneurysm 62.00 10.04 23 121198 415 90506811
Drug level increased 61.48 10.04 123 121098 27639 90479587
Prescribed overdose 61.23 10.04 276 120945 97349 90409877
Coeliac disease 60.52 10.04 163 121058 44447 90462779
Pulmonary embolism 60.28 10.04 339 120882 130481 90376745
Neurotoxicity 59.88 10.04 105 121116 21362 90485864
Epstein-Barr virus infection 58.96 10.04 71 121150 10273 90496953
Pneumonia fungal 58.76 10.04 59 121162 6972 90500254
Knee arthroplasty 58.72 10.04 19 121202 83163 90424063
Blepharospasm 58.50 10.04 4 121217 55441 90451785
Bacteraemia 58.26 10.04 106 121115 22194 90485032
Fluid retention 58.24 10.04 253 120968 87838 90419388
Paraesthesia oral 58.19 10.04 130 121091 31529 90475697
Respiratory symptom 57.95 10.04 47 121174 4205 90503021
Fungal sepsis 57.82 10.04 32 121189 1509 90505717
Dysphagia 57.17 10.04 299 120922 111979 90395247
Autoimmune disorder 56.94 10.04 16 121205 76728 90430498
Lung disorder 55.85 10.04 71 121150 149812 90357414
Bone marrow failure 55.56 10.04 129 121092 32092 90475134
Bone erosion 55.44 10.04 4 121217 53017 90454209
Suicide attempt 55.42 10.04 16 121205 75383 90431843
Aspartate aminotransferase increased 55.10 10.04 278 120943 102659 90404567
Vulvovaginal candidiasis 55.05 10.04 44 121177 3856 90503370
Cholestasis 54.74 10.04 138 121083 36161 90471065
Dermatitis bullous 54.27 10.04 68 121153 10248 90496978
Alanine aminotransferase increased 54.09 10.04 306 120915 118032 90389194
Osteoarthritis 53.95 10.04 113 121108 195617 90311609
Cytomegalovirus test positive 53.88 10.04 42 121179 3549 90503677
Musculoskeletal pain 53.22 10.04 92 121129 171159 90336067
Fatigue 53.09 10.04 1159 120062 1152864 89354362
Blood alkaline phosphatase increased 52.95 10.04 163 121058 47916 90459310
Hip arthroplasty 52.75 10.04 18 121203 76190 90431036
Memory impairment 52.60 10.04 116 121105 197128 90310098
Dizziness 51.80 10.04 521 120700 588763 89918463
Acute myeloid leukaemia recurrent 51.74 10.04 33 121188 2024 90505202
Cryptococcosis 51.00 10.04 29 121192 1442 90505784
Hypomagnesaemia 50.26 10.04 132 121089 35456 90471770
Electrocardiogram QT prolonged 50.13 10.04 211 121010 72245 90434981
Immunosuppressant drug level increased 50.03 10.04 45 121176 4635 90502591
Uterine perforation 50.01 10.04 56 121165 7498 90499728
Leukopenia 49.76 10.04 266 120955 100444 90406782
Acute graft versus host disease 49.63 10.04 48 121173 5420 90501806
Disseminated cryptococcosis 49.50 10.04 23 121198 746 90506480
Acute generalised exanthematous pustulosis 49.02 10.04 75 121146 13628 90493598
Haemophagocytic lymphohistiocytosis 48.93 10.04 80 121141 15379 90491847
Cytomegalovirus infection reactivation 48.54 10.04 56 121165 7744 90499482
Clostridium difficile colitis 48.35 10.04 109 121112 26597 90480629
Insomnia 48.05 10.04 256 120965 333218 90174008
Confusional state 47.94 10.04 311 120910 385894 90121332
Hypokalaemia 47.91 10.04 320 120901 130796 90376430
Agranulocytosis 47.58 10.04 128 121093 34874 90472352
Retinitis viral 47.37 10.04 17 121204 278 90506948
Onychomadesis 46.61 10.04 4 121217 45994 90461232
Blood bilirubin increased 46.60 10.04 146 121075 43324 90463902
Vaginal infection 46.59 10.04 57 121164 8383 90498843
Exposure during pregnancy 46.19 10.04 505 120716 237905 90269321
Cholecystitis chronic 45.79 10.04 61 121160 9765 90497461
Overdose 44.00 10.04 361 120860 157348 90349878
Hyperbilirubinaemia 43.95 10.04 72 121149 13864 90493362
Hepatic function abnormal 43.80 10.04 149 121072 46139 90461087
Klebsiella infection 43.56 10.04 61 121160 10236 90496990
Angioedema 43.39 10.04 187 121034 64689 90442537
Arthritis 43.30 10.04 100 121121 167215 90340011
Stenotrophomonas infection 43.29 10.04 32 121189 2497 90504729
Urticaria 42.90 10.04 244 120977 312490 90194736
Diastolic dysfunction 42.89 10.04 51 121170 7282 90499944
Tumour lysis syndrome 42.69 10.04 63 121158 11089 90496137
Liver function test increased 42.30 10.04 31 121190 84824 90422402
Systemic mycosis 42.14 10.04 26 121195 1504 90505722
Device related infection 42.03 10.04 101 121120 25685 90481541
BK virus infection 41.80 10.04 40 121181 4458 90502768
Rash maculo-papular 41.61 10.04 135 121086 40798 90466428
Geotrichum infection 41.45 10.04 19 121202 597 90506629
Foot deformity 41.44 10.04 14 121207 59637 90447589
Gamma-glutamyltransferase increased 41.17 10.04 128 121093 37824 90469402
Erythema multiforme 40.98 10.04 65 121156 12181 90495045
Cutaneous coccidioidomycosis 40.70 10.04 9 121212 18 90507208
Lupus-like syndrome 40.55 10.04 8 121213 48838 90458388
Hepatic failure 40.36 10.04 131 121090 39597 90467629
Cystitis haemorrhagic 40.20 10.04 43 121178 5470 90501756
Sciatica 39.91 10.04 46 121175 101336 90405890
Escherichia infection 39.57 10.04 74 121147 15821 90491405
Exostosis 39.56 10.04 11 121210 53123 90454103
Gait disturbance 39.19 10.04 197 121024 260299 90246927
Graft versus host disease in skin 39.14 10.04 36 121185 3817 90503409
Gastrointestinal mucormycosis 39.05 10.04 15 121206 299 90506927
Cerebral toxoplasmosis 39.01 10.04 24 121197 1381 90505845
Graft versus host disease in gastrointestinal tract 38.85 10.04 38 121183 4350 90502876
Red blood cell sedimentation rate increased 38.85 10.04 32 121189 82563 90424663
Decreased immune responsiveness 38.77 10.04 53 121168 8695 90498531
Migraine 38.68 10.04 128 121093 190264 90316962
Symmetrical drug-related intertriginous and flexural exanthema 38.58 10.04 21 121200 958 90506268
Condition aggravated 38.42 10.04 563 120658 594982 89912244
Septic embolus 38.23 10.04 21 121200 976 90506250
Candida sepsis 37.85 10.04 25 121196 1628 90505598
Tonsillar haemorrhage 37.82 10.04 14 121207 251 90506975
Jarisch-Herxheimer reaction 37.57 10.04 16 121205 420 90506806
Coccidioidomycosis 37.32 10.04 22 121199 1171 90506055
Stomatitis 37.31 10.04 215 121006 274483 90232743
Hepatic cirrhosis 37.25 10.04 19 121202 63234 90443992
Loss of personal independence in daily activities 37.14 10.04 79 121142 136026 90371200
Taste disorder 36.97 10.04 18 121203 61528 90445698
Procedural pain 36.64 10.04 113 121108 33247 90473979
Thrombotic microangiopathy 36.36 10.04 71 121150 15672 90491554
Enterobacter infection 36.16 10.04 29 121192 2554 90504672
Back injury 35.95 10.04 9 121212 46613 90460613
Staphylococcal sepsis 35.91 10.04 53 121168 9330 90497896
Encephalopathy 35.90 10.04 140 121081 46304 90460922
Joint dislocation 35.57 10.04 8 121213 44574 90462652
Prescribed underdose 35.37 10.04 29 121192 74990 90432236
Pain in extremity 35.26 10.04 409 120812 450120 90057106
Injection site pain 35.13 10.04 117 121104 173582 90333644
Medication error 34.87 10.04 37 121184 84615 90422611
Hypoaesthesia 34.57 10.04 262 120959 313948 90193278
Staphylococcal bacteraemia 34.24 10.04 46 121175 7423 90499803
Walking aid user 33.60 10.04 4 121217 35502 90471724
Haematochezia 33.47 10.04 185 121036 70728 90436498
Joint stiffness 33.41 10.04 33 121188 78009 90429217
Oedema 33.34 10.04 146 121075 200149 90307077
Adverse drug reaction 33.32 10.04 66 121155 116635 90390591
Disseminated coccidioidomycosis 33.25 10.04 11 121210 139 90507087
Overgrowth fungal 32.89 10.04 11 121210 144 90507082
Renal graft infection 32.72 10.04 14 121207 372 90506854
Pleural effusion 32.66 10.04 259 120962 111732 90395494
Disseminated intravascular coagulation 32.60 10.04 82 121139 21456 90485770
Fat necrosis 32.07 10.04 17 121204 735 90506491
Blood immunoglobulin M increased 32.02 10.04 21 121200 1351 90505875
Oral disorder 32.02 10.04 53 121168 10292 90496934
Abscess neck 31.88 10.04 17 121204 744 90506482
Congestive cardiomyopathy 31.76 10.04 44 121177 7310 90499916
Congenital absence of cranial vault 31.66 10.04 7 121214 14 90507212
Blast cell count increased 31.52 10.04 15 121206 514 90506712
Chronic graft versus host disease 31.45 10.04 33 121188 4106 90503120
Transplant rejection 31.26 10.04 59 121162 12699 90494527
Gastritis fungal 31.22 10.04 11 121210 170 90507056
Toxic neuropathy 31.01 10.04 15 121206 533 90506693
Oesophagitis 30.77 10.04 70 121151 17179 90490047
Venoocclusive liver disease 30.72 10.04 39 121182 5954 90501272
Retinitis 30.49 10.04 7 121214 38451 90468775
Shock haemorrhagic 30.47 10.04 57 121164 12188 90495038
Finger deformity 30.42 10.04 4 121217 32893 90474333
Renal impairment 30.30 10.04 243 120978 105178 90402048
Laryngitis 30.25 10.04 15 121206 50738 90456488
Asthma 30.10 10.04 473 120748 241687 90265539
Eosinophilia 29.82 10.04 95 121126 28438 90478788
Blood immunoglobulin A decreased 29.57 10.04 22 121199 1734 90505492
Pulmonary infarction 29.33 10.04 27 121194 2865 90504361
Paraesthesia 29.32 10.04 205 121016 250121 90257105
Arteritis infective 29.29 10.04 9 121212 88 90507138
Neuropathy peripheral 29.26 10.04 296 120925 136674 90370552
Underdose 29.25 10.04 18 121203 53999 90453227
Toxoplasmosis 29.25 10.04 22 121199 1763 90505463
Pneumonia cryptococcal 29.12 10.04 19 121202 1212 90506014
Acquired macroglossia 28.94 10.04 11 121210 213 90507013
Delayed graft function 28.92 10.04 20 121201 1405 90505821
Tricuspid valve incompetence 28.86 10.04 67 121154 16664 90490562
Injection site erythema 28.73 10.04 55 121166 98447 90408779
Respiratory tract infection fungal 28.57 10.04 14 121207 512 90506714
Diverticulum 28.43 10.04 55 121166 12058 90495168
Lung infiltration 28.36 10.04 63 121158 15219 90492007
Product quality issue 28.09 10.04 39 121182 79286 90427940
Pregnancy 28.01 10.04 25 121196 62022 90445204
Malaise 27.83 10.04 585 120636 585401 89921825
Tongue coated 27.82 10.04 21 121200 1692 90505534
Gastrointestinal fungal infection 27.77 10.04 13 121208 429 90506797
Breast cancer 27.63 10.04 19 121202 53742 90453484
Onychomycosis 27.34 10.04 8 121213 37368 90469858
Emphysema 27.09 10.04 54 121167 12101 90495125
Engraftment syndrome 27.05 10.04 15 121206 710 90506516
Acinetobacter infection 26.96 10.04 22 121199 1986 90505240
Mediastinal effusion 26.92 10.04 8 121213 69 90507157
Puerperal pyrexia 26.83 10.04 7 121214 35 90507191
Status epilepticus 26.64 10.04 70 121151 18804 90488422
Basal cell carcinoma 26.62 10.04 6 121215 33383 90473843
Linear IgA disease 26.58 10.04 23 121198 2251 90504975
Adverse reaction 26.56 10.04 4 121217 29708 90477518
Genital pain 26.43 10.04 15 121206 743 90506483
Inappropriate schedule of product administration 26.36 10.04 107 121114 149826 90357400
Emotional distress 26.32 10.04 108 121113 36554 90470672
Muscle spasms 26.31 10.04 213 121008 251670 90255556
Acute graft versus host disease in intestine 26.25 10.04 22 121199 2061 90505165
Varicella zoster virus infection 26.11 10.04 29 121192 3848 90503378
Oral fungal infection 26.10 10.04 27 121194 3305 90503921
Drug eruption 25.97 10.04 105 121116 35302 90471924
Failure to thrive 25.91 10.04 43 121178 8368 90498858
Fungal oesophagitis 25.87 10.04 15 121206 774 90506452
Shock 25.80 10.04 91 121130 28687 90478539
Sepsis syndrome 25.45 10.04 16 121205 957 90506269
Pruritus 25.30 10.04 542 120679 540983 89966243
Ultrasound foetal abnormal 25.26 10.04 9 121212 144 90507082
Sinus polyp 25.22 10.04 12 121209 411 90506815
Splenic vein thrombosis 24.95 10.04 12 121209 421 90506805
Toxic skin eruption 24.87 10.04 61 121160 15713 90491513
Injection site swelling 24.82 10.04 26 121195 59813 90447413
Dyspnoea 24.80 10.04 946 120275 880009 89627217
Antithrombin III decreased 24.59 10.04 10 121211 233 90506993
Anhedonia 24.54 10.04 50 121171 11381 90495845
Accidental exposure to product 24.54 10.04 13 121208 42353 90464873
Resorption bone increased 24.49 10.04 17 121204 1202 90506024
Enterococcal sepsis 24.46 10.04 19 121202 1597 90505629
Colitis ulcerative 24.41 10.04 151 121070 60115 90447111
Raoultella ornithinolytica infection 24.41 10.04 8 121213 98 90507128
Oropharyngeal candidiasis 24.37 10.04 17 121204 1211 90506015
Feeling hot 24.14 10.04 42 121179 77966 90429260
Impaired quality of life 24.13 10.04 77 121144 23067 90484159
Soft tissue neoplasm 24.11 10.04 8 121213 102 90507124
Focal myositis 24.09 10.04 6 121215 24 90507202
Drug abuse 24.00 10.04 46 121175 82301 90424925
Serratia infection 23.86 10.04 16 121205 1069 90506157
Systemic inflammatory response syndrome 23.78 10.04 36 121185 6480 90500746
Therapeutic response decreased 23.72 10.04 53 121168 89676 90417550
Fungal endocarditis 23.70 10.04 11 121210 356 90506870
Pseudomonal sepsis 23.66 10.04 29 121192 4273 90502953
Odynophagia 23.64 10.04 43 121178 9000 90498226
Long QT syndrome 23.49 10.04 28 121193 4009 90503217
Nasal abscess 23.31 10.04 9 121212 182 90507044
Joint neoplasm 23.29 10.04 7 121214 63 90507163
Liver abscess 23.28 10.04 26 121195 3470 90503756
Neuropsychiatric syndrome 22.91 10.04 7 121214 67 90507159
Psoriasis 22.89 10.04 300 120921 147454 90359772
Lymphopenia 22.84 10.04 75 121146 22806 90484420
Wrong technique in product usage process 22.63 10.04 38 121183 71533 90435693
Diabetic macroangiopathy 22.63 10.04 8 121213 125 90507101
Rheumatoid arthritis 22.58 10.04 345 120876 362269 90144957
Oral pain 22.46 10.04 95 121126 32588 90474638
Endotracheal intubation 22.37 10.04 25 121196 3339 90503887
Renal tubular acidosis 22.30 10.04 21 121200 2294 90504932
Nail infection 22.26 10.04 22 121199 2550 90504676
Acute lymphocytic leukaemia 22.17 10.04 23 121198 2825 90504401
Candida test positive 22.08 10.04 15 121206 1024 90506202
Post transplant lymphoproliferative disorder 22.04 10.04 36 121185 6913 90500313
Leukocytosis 22.02 10.04 91 121130 30899 90476327
Dehydration 21.99 10.04 374 120847 194073 90313153
Poor peripheral circulation 21.92 10.04 27 121194 3998 90503228
Livedo reticularis 21.81 10.04 25 121196 3434 90503792
Vulvovaginal mycotic infection 21.80 10.04 34 121187 6280 90500946
Hysterectomy 21.77 10.04 48 121173 11536 90495690
Multiple-drug resistance 21.64 10.04 38 121183 7738 90499488
Stem cell transplant 21.63 10.04 20 121201 2134 90505092
Injection site reaction 21.50 10.04 58 121163 92022 90415204
Acquired apparent mineralocorticoid excess 21.44 10.04 5 121216 14 90507212
Septic pulmonary embolism 21.43 10.04 8 121213 147 90507079
Viral haemorrhagic cystitis 21.41 10.04 17 121204 1476 90505750
Blood immunoglobulin G increased 21.35 10.04 23 121198 2949 90504277
Generalised oedema 21.35 10.04 65 121156 18988 90488238
Blastomycosis 21.31 10.04 11 121210 450 90506776
Amnesia 21.31 10.04 74 121147 108431 90398795
Neutropenic colitis 21.30 10.04 27 121194 4116 90503110
Urinary tract infection fungal 21.28 10.04 13 121208 739 90506487
Diffuse large B-cell lymphoma 21.21 10.04 40 121181 8605 90498621
Blood creatinine increased 21.13 10.04 218 121003 101168 90406058
Necrotising enterocolitis neonatal 21.11 10.04 9 121212 237 90506989
Disease recurrence 21.07 10.04 103 121118 37550 90469676
Graft thrombosis 21.04 10.04 9 121212 239 90506987
Nail disorder 20.95 10.04 29 121192 59038 90448188
Adenovirus reactivation 20.87 10.04 9 121212 244 90506982
Dermatitis atopic 20.85 10.04 74 121147 23398 90483828
Pulmonary haemorrhage 20.82 10.04 38 121183 7975 90499251
Fibrin degradation products increased 20.76 10.04 8 121213 161 90507065
Enterococcal bacteraemia 20.70 10.04 19 121202 2009 90505217
Cardiac arrest 20.63 10.04 223 120998 104712 90402514
Macular degeneration 20.63 10.04 103 121118 37867 90469359
Plasma cell leukaemia 20.61 10.04 15 121206 1143 90506083
Drug intolerance 20.59 10.04 449 120772 447142 90060084
Epilepsy 20.57 10.04 50 121171 82156 90425070
Muscular weakness 20.56 10.04 177 121044 206489 90300737
Engraft failure 20.38 10.04 10 121211 367 90506859
Muscle spasticity 20.22 10.04 11 121210 35311 90471915
Paraspinal abscess 20.14 10.04 9 121212 266 90506960
Growth failure 20.08 10.04 10 121211 379 90506847
Hiatus hernia 20.05 10.04 77 121144 25284 90481942
Nervous system disorder 19.98 10.04 69 121152 21524 90485702
Skin hyperpigmentation 19.74 10.04 34 121187 6817 90500409
Cachexia 19.65 10.04 34 121187 6844 90500382
Disturbance in sexual arousal 19.63 10.04 9 121212 283 90506943
Herpes simplex test positive 19.58 10.04 10 121211 400 90506826
Cystic fibrosis related diabetes 19.49 10.04 6 121215 59 90507167
Graft versus host disease in lung 19.49 10.04 11 121210 539 90506687
Oral mucosal blistering 19.48 10.04 34 121187 6890 90500336
Infection reactivation 19.46 10.04 18 121203 1922 90505304
Blood pressure systolic increased 19.37 10.04 30 121191 58315 90448911
Leukoencephalopathy 19.33 10.04 28 121193 4845 90502381
Nasal polyps 19.24 10.04 44 121177 10836 90496390
Hepatitis acute 19.22 10.04 44 121177 10843 90496383
Band neutrophil count decreased 19.15 10.04 7 121214 121 90507105
Mucosal disorder 19.13 10.04 21 121200 2750 90504476
Cytopenia 19.06 10.04 59 121162 17390 90489836
Philadelphia positive acute lymphocytic leukaemia 19.00 10.04 5 121216 26 90507200
Herpes simplex 18.93 10.04 42 121179 10139 90497087
Off label use 18.90 10.04 1715 119506 1100537 89406689
Respiratory moniliasis 18.89 10.04 8 121213 207 90507019
Poikiloderma 18.89 10.04 9 121212 309 90506917
Perineal pain 18.89 10.04 11 121210 572 90506654
Prothrombin time shortened 18.82 10.04 19 121202 2259 90504967
Renal abscess 18.78 10.04 14 121207 1107 90506119
Cerebral artery thrombosis 18.62 10.04 10 121211 444 90506782
Ulcer haemorrhage 18.59 10.04 6 121215 26315 90480911
Inhibitory drug interaction 18.50 10.04 22 121199 3141 90504085
Frequent bowel movements 18.46 10.04 135 121086 56800 90450426
Haemorrhage 18.38 10.04 157 121064 69212 90438014
Urogenital infection fungal 18.26 10.04 5 121216 31 90507195
Gastrointestinal necrosis 18.16 10.04 22 121199 3203 90504023
Abdominal pain 18.03 10.04 673 120548 395048 90112178
Therapy non-responder 18.01 10.04 108 121113 136596 90370630
Maternal exposure timing unspecified 18.01 10.04 4 121217 22479 90484747
HIV infection 17.89 10.04 10 121211 481 90506745
Incorrect route of product administration 17.81 10.04 25 121196 50601 90456625
Coagulation factor V level decreased 17.79 10.04 9 121212 353 90506873
Scedosporium infection 17.73 10.04 12 121209 814 90506412
Hepatosplenomegaly 17.72 10.04 21 121200 2988 90504238
Hypoxia 17.70 10.04 161 121060 72238 90434988
Tongue blistering 17.63 10.04 17 121204 1913 90505313
Hiccups 17.62 10.04 21 121200 3005 90504221
Atelectasis 17.60 10.04 72 121149 24337 90482889
Clostridial infection 17.47 10.04 26 121195 4610 90502616
BK polyomavirus test positive 17.46 10.04 7 121214 157 90507069
Blood pressure increased 17.42 10.04 174 121047 197043 90310183
Hepatotoxicity 17.41 10.04 113 121108 45729 90461497
Encephalitis fungal 17.38 10.04 6 121215 87 90507139
Mechanical ventilation 17.34 10.04 15 121206 1467 90505759
Haemodialysis 17.30 10.04 37 121184 8710 90498516
Transfusion 17.17 10.04 57 121164 17431 90489795
Abscess 17.16 10.04 60 121161 18831 90488395
Wound infection fungal 17.14 10.04 7 121214 165 90507061
Blood culture positive 17.08 10.04 27 121194 5045 90502181
Haemodynamic instability 17.04 10.04 44 121177 11695 90495531
Persistent genital arousal disorder 17.04 10.04 11 121210 689 90506537
Chronic lymphocytic leukaemia recurrent 16.96 10.04 9 121212 390 90506836
Vulvovaginitis 16.90 10.04 9 121212 393 90506833
Jaundice 16.82 10.04 87 121134 32430 90474796
Rectal haemorrhage 16.80 10.04 177 121044 82567 90424659
Ureaplasma infection 16.74 10.04 12 121209 893 90506333
Fungal test positive 16.72 10.04 10 121211 547 90506679
Visual impairment 16.69 10.04 106 121115 132259 90374967
Restlessness 16.60 10.04 14 121207 35706 90471520
Metabolic acidosis 16.36 10.04 129 121092 55547 90451679
Herpes simplex viraemia 16.33 10.04 9 121212 421 90506805
Alkalosis 16.28 10.04 10 121211 574 90506652
Vulvovaginal discomfort 16.18 10.04 19 121202 2678 90504548
Refractory anaemia with an excess of blasts 16.08 10.04 9 121212 434 90506792
Petechiae 16.07 10.04 52 121169 15689 90491537
Incorrect dose administered 16.06 10.04 53 121168 78877 90428349
Infective chondritis 16.06 10.04 4 121217 16 90507210
Pharyngeal stenosis 16.06 10.04 4 121217 16 90507210
PRIDE syndrome 16.06 10.04 4 121217 16 90507210
Urinary tract infection enterococcal 16.05 10.04 20 121201 2996 90504230
Hypoglossal nerve paresis 15.94 10.04 6 121215 113 90507113
Vulvovaginal pruritus 15.93 10.04 23 121198 3970 90503256
Stoma site candida 15.86 10.04 4 121217 17 90507209
Neural tube defect 15.86 10.04 7 121214 201 90507025
Staphylococcus test positive 15.85 10.04 24 121197 4321 90502905
Purpura senile 15.80 10.04 10 121211 605 90506621
Hypoalbuminaemia 15.77 10.04 52 121169 15845 90491381
Vulvovaginal swelling 15.75 10.04 11 121210 785 90506441
Acute respiratory distress syndrome 15.71 10.04 78 121143 28608 90478618
Blood beta-D-glucan increased 15.67 10.04 8 121213 320 90506906
Rheumatic disorder 15.64 10.04 21 121200 3387 90503839
Oedema mucosal 15.58 10.04 13 121208 1210 90506016
Rhinocerebral mucormycosis 15.56 10.04 11 121210 801 90506425
Gallbladder disorder 15.55 10.04 60 121161 19743 90487483
Periostitis 15.55 10.04 9 121212 463 90506763
Respiratory tract haemorrhage 15.53 10.04 9 121212 464 90506762
Female reproductive tract disorder 15.49 10.04 10 121211 626 90506600
Cushing's syndrome 15.49 10.04 10 121211 626 90506600
Coagulopathy 15.47 10.04 67 121154 23222 90484004
Lichenoid keratosis 15.45 10.04 18 121203 2516 90504710
Vaginal mucosal blistering 15.35 10.04 5 121216 60 90507166
Myelodysplastic syndrome 15.34 10.04 62 121159 20841 90486385
Hepatic artery aneurysm 15.33 10.04 4 121217 20 90507206
Angina bullosa haemorrhagica 15.29 10.04 6 121215 127 90507099
Gingival ulceration 15.21 10.04 12 121209 1032 90506194
Hypophagia 15.16 10.04 91 121130 35846 90471380
Anticoagulation drug level above therapeutic 15.15 10.04 16 121205 2006 90505220
Therapeutic product effect incomplete 15.14 10.04 176 121045 193720 90313506
Skin exfoliation 15.10 10.04 148 121073 67765 90439461
Renal tubular disorder 15.08 10.04 20 121201 3187 90504039
Pneumothorax 14.99 10.04 58 121163 19109 90488117
Acid base balance abnormal 14.96 10.04 8 121213 352 90506874
Nephropathy toxic 14.89 10.04 44 121177 12644 90494582
CD4 lymphocytes decreased 14.84 10.04 14 121207 1533 90505693
Porphyria acute 14.80 10.04 3 121218 17972 90489254
Neutropenic infection 14.79 10.04 15 121206 1794 90505432
Angioimmunoblastic T-cell lymphoma 14.76 10.04 7 121214 238 90506988
Heliotrope rash 14.76 10.04 7 121214 238 90506988
Brain oedema 14.75 10.04 54 121167 17331 90489895
Leukaemia 14.68 10.04 25 121196 4967 90502259
Pancreatitis necrotising 14.66 10.04 17 121204 2364 90504862
Blood pressure fluctuation 14.65 10.04 30 121191 52383 90454843
Injection site bruising 14.57 10.04 30 121191 52277 90454949
Gastrointestinal oedema 14.54 10.04 14 121207 1572 90505654
Platelet transfusion 14.47 10.04 12 121209 1108 90506118
Acute lymphocytic leukaemia recurrent 14.41 10.04 18 121203 2703 90504523
Sinusitis 14.41 10.04 349 120872 342739 90164487
Injection site warmth 14.26 10.04 3 121218 17512 90489714
Depression 14.26 10.04 300 120921 300301 90206925
Intentional self-injury 14.25 10.04 11 121210 29323 90477903
Streptococcal endocarditis 14.22 10.04 6 121215 154 90507072
Epstein-Barr virus infection reactivation 14.17 10.04 14 121207 1623 90505603
Mucosal toxicity 14.14 10.04 8 121213 394 90506832
Post procedural bile leak 14.11 10.04 6 121215 157 90507069
Allergy test positive 14.09 10.04 10 121211 732 90506494
Neck pain 13.99 10.04 92 121129 113871 90393355
Bronchiolitis obliterans syndrome 13.97 10.04 8 121213 403 90506823
Immunosuppressant drug level decreased 13.96 10.04 12 121209 1164 90506062
Brain abscess 13.94 10.04 18 121203 2794 90504432
Tarsal tunnel syndrome 13.88 10.04 9 121212 568 90506658
Kidney transplant rejection 13.86 10.04 24 121197 4833 90502393
Extremity necrosis 13.81 10.04 15 121206 1942 90505284
Gastrointestinal viral infection 13.80 10.04 13 121208 1420 90505806
Coagulation time prolonged 13.79 10.04 14 121207 1676 90505550
Leukaemic infiltration extramedullary 13.70 10.04 6 121215 169 90507057
Fungal skin infection 13.60 10.04 25 121196 5276 90501950
Oliguria 13.59 10.04 38 121183 10586 90496640
Malnutrition 13.58 10.04 55 121166 18503 90488723
Liver transplant rejection 13.53 10.04 14 121207 1714 90505512
Myelosuppression 13.52 10.04 120 121101 53471 90453755
Aeromonas infection 13.50 10.04 6 121215 175 90507051
Disability 13.48 10.04 21 121200 40724 90466502
H1N1 influenza 13.48 10.04 15 121206 1995 90505231
Biliary dyskinesia 13.46 10.04 17 121204 2582 90504644
Encephalitis 13.44 10.04 39 121182 11095 90496131
Primary adrenal insufficiency 13.44 10.04 7 121214 292 90506934
Acute sinusitis 13.42 10.04 22 121199 4239 90502987
Back pain 13.39 10.04 535 120686 316640 90190586
Idiopathic intracranial hypertension 13.38 10.04 20 121201 3561 90503665
Chronic hepatitis C 13.35 10.04 6 121215 180 90507046
Hyperglycaemia 13.31 10.04 115 121106 50855 90456371
Vulvovaginal disorder 13.25 10.04 3 121218 7 90507219
Supraventricular tachycardia 13.24 10.04 50 121171 16286 90490940
Acinetobacter test positive 13.19 10.04 5 121216 96 90507130
Duodenal stenosis 13.16 10.04 9 121212 621 90506605
Ileus paralytic 13.07 10.04 24 121197 5061 90502165
Tinea capitis 13.03 10.04 4 121217 39 90507187
Secondary amyloidosis 13.02 10.04 6 121215 191 90507035
Labelled drug-drug interaction medication error 12.98 10.04 46 121175 14536 90492690
Rash morbilliform 12.95 10.04 21 121200 4008 90503218
Acute respiratory failure 12.92 10.04 100 121121 42818 90464408
Mucosal erosion 12.77 10.04 14 121207 1831 90505395
Adrenal insufficiency 12.77 10.04 76 121145 29845 90477381
Ear infection 12.77 10.04 49 121172 69726 90437500
Herpes simplex oesophagitis 12.76 10.04 6 121215 200 90507026
Gallbladder fibrosis 12.71 10.04 3 121218 9 90507217
Mycobacterium avium complex infection 12.69 10.04 21 121200 4077 90503149
Asthenia 12.68 10.04 584 120637 533167 89974059
Venoocclusive disease 12.62 10.04 16 121205 2439 90504787
Capillary leak syndrome 12.62 10.04 17 121204 2750 90504476
Lymphatic disorder 12.60 10.04 8 121213 487 90506739
Toxicity to various agents 12.58 10.04 291 120930 287555 90219671
Meningitis 12.53 10.04 32 121189 8449 90498777
Sleep apnoea syndrome 12.51 10.04 79 121142 31668 90475558
Out of specification test results 12.48 10.04 5 121216 112 90507114
Lymphocyte count decreased 12.47 10.04 85 121136 34965 90472261
Xanthopsia 12.44 10.04 6 121215 212 90507014
Posterior reversible encephalopathy syndrome 12.42 10.04 61 121160 22278 90484948
Vertebral lateral recess stenosis 12.37 10.04 7 121214 345 90506881
Clostridium difficile infection 12.36 10.04 87 121134 36158 90471068
Heparin-induced thrombocytopenia 12.32 10.04 24 121197 5288 90501938
Infection in an immunocompromised host 12.32 10.04 10 121211 896 90506330
Pseudomembranous colitis 12.22 10.04 20 121201 3848 90503378
Epidermolysis 12.20 10.04 9 121212 700 90506526
Cushingoid 12.15 10.04 36 121185 10359 90496867
Subdiaphragmatic abscess 12.13 10.04 4 121217 50 90507176
Acute febrile neutrophilic dermatosis 12.12 10.04 19 121202 3526 90503700
Complications of transplanted kidney 12.10 10.04 17 121204 2861 90504365
Osteoarthropathy 12.08 10.04 7 121214 361 90506865
Lymphocyte count 12.04 10.04 3 121218 12 90507214
Thrombocytosis 12.03 10.04 28 121193 6973 90500253
Treatment failure 11.99 10.04 312 120909 303616 90203610
Hypoxic-ischaemic encephalopathy 11.95 10.04 22 121199 4646 90502580
Ligamentum flavum hypertrophy 11.92 10.04 7 121214 370 90506856
Blood triglycerides increased 11.90 10.04 43 121178 13718 90493508
Urinary tract infection 11.87 10.04 511 120710 305121 90202105
Paraneoplastic rash 11.86 10.04 5 121216 128 90507098
Capnocytophaga infection 11.85 10.04 3 121218 13 90507213
Injury 11.85 10.04 189 121032 197160 90310066
Gastrooesophageal reflux disease 11.85 10.04 154 121067 166183 90341043
Exposure via breast milk 11.76 10.04 15 121206 2300 90504926
Haematoma 11.76 10.04 91 121130 38957 90468269
Aplasia 11.76 10.04 20 121201 3971 90503255
Bartonellosis 11.67 10.04 3 121218 14 90507212
Citrobacter test positive 11.67 10.04 3 121218 14 90507212
Blood chloride decreased 11.67 10.04 26 121195 6293 90500933
Flushing 11.60 10.04 70 121151 88421 90418805
Diabetic hyperosmolar coma 11.60 10.04 7 121214 389 90506837
Dystonia 11.59 10.04 4 121217 16815 90490411
Epstein-Barr virus associated lymphoproliferative disorder 11.58 10.04 16 121205 2651 90504575
Anencephaly 11.57 10.04 7 121214 391 90506835
Transferrin decreased 11.57 10.04 7 121214 391 90506835
Sedation 11.50 10.04 30 121191 48141 90459085
CSF culture positive 11.50 10.04 3 121218 15 90507211
Central nervous system lymphoma 11.49 10.04 14 121207 2051 90505175
Generalised tonic-clonic seizure 11.45 10.04 83 121138 34820 90472406
Klebsiella test positive 11.45 10.04 12 121209 1491 90505735
Thrombophlebitis 11.43 10.04 22 121199 4806 90502420
Enterobacter test positive 11.35 10.04 6 121215 258 90506968
Metapneumovirus pneumonia 11.34 10.04 4 121217 62 90507164
Schizophrenia 11.27 10.04 3 121218 14911 90492315
Injection site urticaria 11.23 10.04 5 121216 18006 90489220
Skin lesion 11.21 10.04 87 121134 37278 90469948
Splenic infarction 11.15 10.04 14 121207 2113 90505113
Rhodococcus infection 11.15 10.04 5 121216 149 90507077
Mucosa vesicle 11.15 10.04 5 121216 149 90507077
Lower respiratory tract infection fungal 11.14 10.04 6 121215 268 90506958
Blood disorder 11.11 10.04 29 121192 7761 90499465
Granulicatella infection 11.09 10.04 5 121216 151 90507075
Hepatic enzyme increased 11.09 10.04 383 120838 360353 90146873
Fracture 11.08 10.04 8 121213 22068 90485158
Oropharyngeal pain 11.07 10.04 216 121005 114971 90392255
Respiratory syncytial virus infection 11.05 10.04 35 121186 10445 90496781
Disease progression 11.04 10.04 281 120940 156334 90350892
No adverse event 11.03 10.04 50 121171 67932 90439294
Rhinorrhoea 10.99 10.04 71 121150 88245 90418981
General symptom 10.99 10.04 3 121218 14665 90492561
Pulmonary oedema 10.87 10.04 129 121092 61951 90445275
Pathological fracture 10.87 10.04 33 121188 9627 90497599
Cheilitis 10.86 10.04 22 121199 4985 90502241
Panniculitis 10.75 10.04 3 121218 14455 90492771
Gastric mucosal lesion 10.74 10.04 8 121213 632 90506594
Cross sensitivity reaction 10.73 10.04 16 121205 2841 90504385
Lung abscess 10.72 10.04 14 121207 2199 90505027
Thrombophlebitis septic 10.71 10.04 6 121215 290 90506936
Cardiomyopathy acute 10.71 10.04 6 121215 290 90506936
Nosocomial infection 10.69 10.04 13 121208 1900 90505326
Enterocolitis bacterial 10.67 10.04 6 121215 292 90506934
Laryngeal haematoma 10.65 10.04 3 121218 21 90507205
Anal candidiasis 10.65 10.04 3 121218 21 90507205
Hallucinations, mixed 10.62 10.04 24 121197 5865 90501361
Streptococcal sepsis 10.61 10.04 18 121203 3566 90503660
Opsoclonus myoclonus 10.60 10.04 5 121216 168 90507058
Headache 10.59 10.04 1313 119908 861433 89645793
Pneumonia influenzal 10.58 10.04 14 121207 2226 90505000
Iron binding capacity total decreased 10.55 10.04 7 121214 459 90506767
Cholelithiasis 10.51 10.04 112 121109 52394 90454832
Blood sodium decreased 10.44 10.04 68 121153 27545 90479681
Spondylitis 10.43 10.04 3 121218 14175 90493051
Feeling abnormal 10.43 10.04 159 121062 167076 90340150
Vulvovaginal burning sensation 10.43 10.04 15 121206 2580 90504646
Herpes virus infection 10.40 10.04 25 121196 6359 90500867
Chest pain 10.38 10.04 337 120884 319308 90187918
Dermatitis diaper 10.36 10.04 6 121215 309 90506917
Palatal oedema 10.31 10.04 8 121213 671 90506555
Pneumonia 10.31 10.04 989 120232 637070 89870156
Dementia 10.31 10.04 10 121211 23851 90483375
Infusion related reaction 10.30 10.04 454 120767 416326 90090900
Pharyngeal swelling 10.29 10.04 33 121188 9911 90497315
Withdrawal syndrome 10.26 10.04 9 121212 22515 90484711
Mental status changes 10.24 10.04 98 121123 44581 90462645
Gallbladder hypofunction 10.21 10.04 7 121214 485 90506741
Respiratory tract congestion 10.19 10.04 13 121208 27397 90479829
Pseudomonas test positive 10.17 10.04 9 121212 907 90506319
Hepatocellular injury 10.16 10.04 70 121151 28888 90478338
Blood albumin decreased 10.15 10.04 47 121174 16756 90490470
Hepatorenal failure 10.13 10.04 8 121213 689 90506537
Enterocolitis 10.13 10.04 34 121187 10456 90496770
Potentiating drug interaction 10.12 10.04 23 121198 5639 90501587
Hyperkalaemia 10.09 10.04 132 121089 64832 90442394
Agonal rhythm 10.08 10.04 3 121218 26 90507200
Fungal pharyngitis 10.08 10.04 5 121216 188 90507038
Ventricular tachycardia 10.06 10.04 62 121159 24646 90482580
Genital haemorrhage 10.05 10.04 30 121191 8672 90498554

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 677.88 10.66 1294 85781 184409 42349851
Immune reconstitution inflammatory syndrome 383.65 10.66 246 86829 9897 42524363
Candida infection 336.80 10.66 309 86766 21301 42512959
Drug interaction 307.71 10.66 1217 85858 265782 42268478
Mucormycosis 257.22 10.66 168 86907 6975 42527285
Pancytopenia 238.65 10.66 651 86424 117092 42417168
Pyrexia 236.96 10.66 1493 85582 392549 42141711
Aplastic anaemia 224.61 10.66 193 86882 12191 42522069
Aspergillus infection 189.57 10.66 196 86879 15641 42518619
Cytokine release syndrome 189.12 10.66 332 86743 44195 42490065
Pathogen resistance 186.73 10.66 168 86907 11282 42522978
Mucosal inflammation 185.42 10.66 349 86726 49025 42485235
Multiple organ dysfunction syndrome 185.16 10.66 525 86550 96510 42437750
Neutropenia 184.36 10.66 851 86224 198580 42335680
Meningitis cryptococcal 176.96 10.66 100 86975 3183 42531077
Drug abuse 164.86 10.66 13 87062 104758 42429502
Toxic epidermal necrolysis 164.08 10.66 236 86839 26514 42507746
Septic shock 161.43 10.66 482 86593 91190 42443070
Drug resistance 152.78 10.66 261 86814 33987 42500273
Graft versus host disease 149.38 10.66 157 86918 12768 42521492
Sepsis 146.27 10.66 797 86278 198537 42335723
Completed suicide 141.09 10.66 16 87059 96449 42437811
Enterococcal infection 136.93 10.66 145 86930 11894 42522366
Platelet count decreased 135.85 10.66 602 86473 137979 42396281
Fungal infection 131.33 10.66 181 86894 19541 42514719
Thrombocytopenia 125.82 10.66 740 86335 189539 42344721
Neutrophil count decreased 122.73 10.66 345 86730 63070 42471190
Bronchopulmonary aspergillosis 121.47 10.66 173 86902 19256 42515004
Cryptococcosis 119.23 10.66 77 86998 3134 42531126
Systemic candida 115.43 10.66 92 86983 5227 42529033
Acute myeloid leukaemia 110.50 10.66 178 86897 22078 42512182
Cytomegalovirus infection 107.41 10.66 217 86858 32089 42502171
Arthralgia 96.18 10.66 170 86905 205068 42329192
Product dose omission issue 95.15 10.66 105 86970 154260 42380000
Fall 94.68 10.66 212 86863 234308 42299952
Disseminated intravascular coagulation 93.95 10.66 176 86899 24618 42509642
Dyspnoea 93.01 10.66 528 86547 442093 42092167
Oral candidiasis 91.13 10.66 129 86946 14276 42519984
Torsade de pointes 86.39 10.66 97 86978 8497 42525763
Hepatotoxicity 85.99 10.66 171 86904 24996 42509264
Electrocardiogram QT prolonged 84.22 10.66 252 86823 47693 42486567
Systemic mycosis 83.15 10.66 55 87020 2332 42531928
Immunosuppressant drug level increased 82.44 10.66 90 86985 7641 42526619
Fatigue 81.41 10.66 539 86536 435102 42099158
Pseudomonas infection 81.30 10.66 129 86946 15794 42518466
Suicide attempt 80.89 10.66 3 87072 46097 42488163
White blood cell count decreased 79.18 10.66 439 86636 109957 42424303
Pain 77.88 10.66 249 86826 244599 42289661
Dizziness 76.85 10.66 257 86818 248997 42285263
Intentional overdose 76.57 10.66 8 87067 51448 42482812
Tumour lysis syndrome 74.69 10.66 150 86925 22081 42512179
Inappropriate schedule of product administration 73.75 10.66 53 87022 95849 42438411
Joint swelling 71.16 10.66 25 87050 67997 42466263
Myocardial infarction 70.36 10.66 90 86985 123919 42410341
Blood bilirubin increased 69.46 10.66 217 86858 42035 42492225
Respiratory failure 68.87 10.66 473 86602 127659 42406601
Stevens-Johnson syndrome 67.87 10.66 144 86931 22034 42512226
Cytomegalovirus viraemia 67.22 10.66 94 86981 10283 42523977
Neurotoxicity 67.17 10.66 149 86926 23502 42510758
Agranulocytosis 66.66 10.66 174 86901 30438 42503822
Peripheral swelling 65.43 10.66 53 87022 90217 42444043
Pneumonia 64.23 10.66 1214 85861 420935 42113325
Fungaemia 63.30 10.66 52 87023 3084 42531176
Overdose 63.30 10.66 73 87002 105191 42429069
Acinetobacter infection 62.54 10.66 39 87036 1492 42532768
Stress 60.61 10.66 9 87066 44203 42490057
Immune effector cell-associated neurotoxicity syndrome 60.24 10.66 85 86990 9376 42524884
Pain in extremity 60.01 10.66 137 86938 150467 42383793
Candida sepsis 59.51 10.66 37 87038 1408 42532852
Oesophageal candidiasis 59.04 10.66 65 87010 5570 42528690
Bacteraemia 58.32 10.66 146 86929 24894 42509366
Bone marrow failure 58.16 10.66 174 86901 32919 42501341
Encephalitis 57.90 10.66 82 86993 9076 42525184
Drug level increased 57.12 10.66 149 86926 26051 42508209
Staphylococcal infection 57.03 10.66 188 86887 37455 42496805
Intentional product misuse 56.30 10.66 28 87047 61872 42472388
Drug reaction with eosinophilia and systemic symptoms 54.92 10.66 200 86875 41875 42492385
Death 54.82 10.66 658 86417 470527 42063733
Lymphocyte count decreased 54.45 10.66 152 86923 27657 42506603
Alanine aminotransferase increased 53.95 10.66 337 86738 88069 42446191
HIV infection 53.63 10.66 35 87040 1450 42532810
Rheumatoid arthritis 53.03 10.66 11 87064 42429 42491831
Anxiety 52.11 10.66 102 86973 118458 42415802
Conductive deafness 52.02 10.66 24 87051 493 42533767
Wrong technique in product usage process 51.35 10.66 12 87063 42623 42491637
Klebsiella infection 50.03 10.66 86 86989 11246 42523014
Injection site pain 48.41 10.66 29 87046 57769 42476491
Acute graft versus host disease 48.20 10.66 71 87004 8144 42526116
Suicidal ideation 48.18 10.66 19 87056 48142 42486118
Loss of personal independence in daily activities 47.67 10.66 21 87054 49795 42484465
Leukopenia 47.53 10.66 288 86787 74458 42459802
Nasopharyngitis 46.55 10.66 62 87013 83934 42450326
Acute graft versus host disease in skin 46.24 10.66 66 87009 7358 42526902
Pneumonia cryptococcal 45.98 10.66 32 87043 1476 42532784
Haemophagocytic lymphohistiocytosis 45.36 10.66 109 86966 18113 42516147
Memory impairment 45.25 10.66 23 87052 50199 42484061
Cytomegalovirus chorioretinitis 44.57 10.66 51 87024 4560 42529700
Hyperhidrosis 44.14 10.66 73 87002 90439 42443821
Venoocclusive liver disease 43.94 10.66 77 86998 10225 42524035
Toxicity to various agents 43.91 10.66 281 86794 228855 42305405
Blood lactate dehydrogenase increased 43.83 10.66 135 86940 25946 42508314
Plasma cell myeloma 43.76 10.66 203 86872 47375 42486885
Prostate cancer 42.43 10.66 19 87056 44624 42489636
Coagulopathy 42.27 10.66 120 86955 22042 42512218
Clostridium difficile colitis 41.44 10.66 116 86959 21136 42513124
Depression 41.41 10.66 105 86970 111258 42423002
Feeling abnormal 41.29 10.66 49 87026 69737 42464523
Cardiac failure congestive 40.85 10.66 70 87005 85532 42448728
Chronic obstructive pulmonary disease 39.87 10.66 42 87033 63072 42471188
Nocardiosis 39.72 10.66 51 87024 5139 42529121
Pseudomembranous colitis 39.71 10.66 40 87035 3093 42531167
Blood pressure increased 39.55 10.66 94 86981 101834 42432426
Abdominal discomfort 39.26 10.66 58 87017 75197 42459063
Insomnia 39.12 10.66 118 86957 118135 42416125
Disseminated cryptococcosis 39.02 10.66 32 87043 1893 42532367
Aspartate aminotransferase increased 38.58 10.66 280 86795 76883 42457377
Cystitis haemorrhagic 38.27 10.66 60 87015 7269 42526991
Rash maculo-papular 38.24 10.66 165 86910 37338 42496922
Hyperbilirubinaemia 37.68 10.66 110 86965 20525 42513735
Fungal skin infection 37.56 10.66 40 87035 3301 42530959
Intracranial pressure increased 37.46 10.66 47 87028 4627 42529633
Acquired immunodeficiency syndrome 37.28 10.66 19 87056 489 42533771
Human ehrlichiosis 37.28 10.66 19 87056 489 42533771
Drug intolerance 37.26 10.66 67 87008 80357 42453903
Musculoskeletal stiffness 36.99 10.66 38 87037 57727 42476533
Chest pain 36.95 10.66 153 86922 139377 42394883
Stomatitis 36.61 10.66 201 86874 50128 42484132
Hepatic failure 36.10 10.66 164 86911 37936 42496324
Acute myeloid leukaemia recurrent 35.91 10.66 40 87035 3472 42530788
Acute respiratory distress syndrome 35.87 10.66 139 86936 29969 42504291
Disseminated coccidioidomycosis 35.85 10.66 12 87063 99 42534161
Trichosporon infection 35.76 10.66 23 87052 929 42533331
Drug-induced liver injury 35.71 10.66 164 86911 38109 42496151
Drug ineffective 35.54 10.66 1599 85476 628598 41905662
Graft versus host disease in gastrointestinal tract 35.43 10.66 48 87027 5095 42529165
Chronic graft versus host disease 35.25 10.66 52 87023 5973 42528287
Fusarium infection 35.16 10.66 28 87047 1588 42532672
Gait disturbance 34.45 10.66 95 86980 97905 42436355
Arthropathy 34.34 10.66 9 87066 29588 42504672
Brain abscess 34.21 10.66 43 87032 4241 42530019
Chest discomfort 34.19 10.66 48 87027 63568 42470692
Increased viscosity of upper respiratory secretion 34.14 10.66 16 87059 341 42533919
Weight increased 34.13 10.66 110 86965 107873 42426387
Hepatic function abnormal 33.61 10.66 200 86875 51367 42482893
Cerebrovascular accident 33.55 10.66 95 86980 97065 42437195
Pneumonia fungal 33.49 10.66 64 87011 9082 42525178
Periorbital cellulitis 33.43 10.66 16 87059 358 42533902
Cerebral toxoplasmosis 32.66 10.66 30 87045 2068 42532192
Asthma 32.52 10.66 48 87027 62266 42471994
Cough 32.29 10.66 222 86853 177881 42356379
Therapeutic product effect incomplete 32.06 10.66 60 87015 70879 42463381
Aplasia 31.56 10.66 44 87031 4799 42529461
Hyperferritinaemia 31.51 10.66 18 87057 585 42533675
Clostridium test positive 31.47 10.66 47 87028 5458 42528802
Device related infection 31.35 10.66 102 86973 20177 42514083
Phalangeal hypoplasia 31.30 10.66 10 87065 70 42534190
Encephalitis fungal 30.80 10.66 13 87062 214 42534046
Sedation 30.52 10.66 12 87063 30463 42503797
Differentiation syndrome 30.34 10.66 27 87048 1786 42532474
Hepatitis cholestatic 30.30 10.66 64 87011 9760 42524500
Nightmare 30.20 10.66 7 87068 25005 42509255
Blood alkaline phosphatase increased 29.90 10.66 142 86933 33455 42500805
Drug dependence 29.90 10.66 11 87064 29083 42505177
Gastrointestinal mucormycosis 29.79 10.66 15 87060 376 42533884
Klebsiella sepsis 29.77 10.66 32 87043 2669 42531591
Incorrect dose administered 29.45 10.66 39 87036 52935 42481325
Acute kidney injury 29.39 10.66 969 86106 366368 42167892
Liver disorder 29.28 10.66 159 86916 39485 42494775
Pulmonary haemorrhage 29.25 10.66 69 87006 11328 42522932
Penis injury 29.15 10.66 13 87062 246 42534014
Epidermolysis bullosa 29.13 10.66 11 87064 133 42534127
Pulmonary mucormycosis 29.10 10.66 24 87051 1431 42532829
Toxic neuropathy 29.06 10.66 17 87058 578 42533682
Oropharyngeal candidiasis 29.00 10.66 20 87055 909 42533351
Malaise 28.66 10.66 286 86789 211870 42322390
Stiff person syndrome 28.51 10.66 12 87063 196 42534064
Portal fibrosis 28.51 10.66 14 87061 332 42533928
Congenital multiplex arthrogryposis 28.49 10.66 13 87062 260 42534000
Enterococcal bacteraemia 28.35 10.66 31 87044 2636 42531624
Angina pectoris 28.26 10.66 16 87059 32880 42501380
Sleep disorder 28.20 10.66 34 87041 48061 42486199
Psoriatic arthropathy 28.20 10.66 8 87067 24959 42509301
Intentional product use issue 28.05 10.66 66 87009 71767 42462493
Coccidioidomycosis 27.96 10.66 19 87056 843 42533417
Headache 27.82 10.66 334 86741 239035 42295225
Hypertension 27.61 10.66 214 86861 166990 42367270
Swollen tongue 27.58 10.66 5 87070 21226 42513034
Enterococcal sepsis 27.58 10.66 27 87048 2017 42532243
Acute myocardial infarction 27.35 10.66 48 87027 58117 42476143
Long QT syndrome 27.24 10.66 33 87042 3134 42531126
Cardiac disorder 27.22 10.66 36 87039 48896 42485364
Cerebral palsy 26.62 10.66 14 87061 385 42533875
Aortoenteric fistula 26.33 10.66 10 87065 123 42534137
Aggression 26.13 10.66 31 87044 44132 42490128
Porphyria acute 26.08 10.66 14 87061 402 42533858
Encephalitis viral 26.06 10.66 23 87052 1505 42532755
Staphylococcal bacteraemia 26.05 10.66 65 87010 11056 42523204
Mycobacterium fortuitum infection 26.04 10.66 14 87061 403 42533857
Blood corticosterone increased 25.98 10.66 5 87070 0 42534260
Stenotrophomonas test positive 25.85 10.66 13 87062 325 42533935
Electrocardiogram J wave abnormal 25.69 10.66 6 87069 9 42534251
Central nervous system vasculitis 25.52 10.66 16 87059 618 42533642
Infection 25.49 10.66 345 86730 111723 42422537
Hypoalbuminaemia 25.48 10.66 80 86995 15530 42518730
Arthritis 25.45 10.66 29 87046 42036 42492224
Rhinovirus infection 25.44 10.66 47 87028 6501 42527759
C-reactive protein increased 25.36 10.66 219 86856 63341 42470919
Osteomyelitis fungal 25.32 10.66 13 87062 340 42533920
Acute lymphocytic leukaemia 25.14 10.66 33 87042 3398 42530862
Toxoplasmosis 25.06 10.66 23 87052 1584 42532676
Cholestasis 25.05 10.66 133 86942 32746 42501514
Stem cell transplant 24.89 10.66 29 87046 2643 42531617
Musculoskeletal pain 24.87 10.66 19 87056 33321 42500939
Cytomegalovirus test positive 24.87 10.66 37 87038 4282 42529978
Adrenal insufficiency 24.72 10.66 90 86985 18834 42515426
Blood pressure fluctuation 24.72 10.66 12 87063 26896 42507364
Hospitalisation 24.69 10.66 74 87001 74256 42460004
Venoocclusive disease 24.67 10.66 35 87040 3880 42530380
Heart rate decreased 24.58 10.66 23 87052 36509 42497751
Kaposi's sarcoma 24.55 10.66 17 87058 778 42533482
Dysbiosis 24.43 10.66 17 87058 784 42533476
Wound infection fungal 24.24 10.66 7 87068 33 42534227
Trichoglossia 24.19 10.66 13 87062 374 42533886
Renal failure 24.05 10.66 420 86655 143306 42390954
Fungal test positive 24.05 10.66 15 87060 574 42533686
Psoriasis 23.87 10.66 39 87036 48565 42485695
Osteoarthritis 23.80 10.66 10 87065 24395 42509865
Mycobacterial peritonitis 23.78 10.66 10 87065 163 42534097
Allergic keratitis 23.69 10.66 6 87069 15 42534245
Therapeutic product effect decreased 23.68 10.66 27 87048 39123 42495137
Hepatosplenic candidiasis 23.66 10.66 11 87064 230 42534030
Atelectasis 23.56 10.66 90 86985 19271 42514989
Gingivitis ulcerative 23.53 10.66 11 87064 233 42534027
Bacterial sepsis 23.29 10.66 45 87030 6437 42527823
Blood culture positive 23.17 10.66 39 87036 5014 42529246
Odynophagia 23.12 10.66 46 87029 6724 42527536
Somnolence 23.10 10.66 181 86894 140924 42393336
SARS-CoV-2 sepsis 23.07 10.66 11 87064 244 42534016
Idiosyncratic drug reaction 23.02 10.66 14 87061 512 42533748
Cachexia 22.94 10.66 51 87024 8053 42526207
Nephropathy toxic 22.78 10.66 81 86994 16757 42517503
Systemic inflammatory response syndrome 22.62 10.66 48 87027 7342 42526918
Heart rate irregular 22.62 10.66 3 87072 16047 42518213
Penile haemorrhage 22.62 10.66 18 87057 1020 42533240
Liver abscess 22.31 10.66 38 87037 4932 42529328
Product prescribing error 22.00 10.66 13 87062 26099 42508161
Gallstone ileus 21.98 10.66 6 87069 22 42534238
Aspartate aminotransferase 21.90 10.66 9 87066 138 42534122
Engraftment syndrome 21.88 10.66 20 87055 1370 42532890
Geotrichum infection 21.82 10.66 14 87061 563 42533697
Gamma-glutamyltransferase increased 21.79 10.66 127 86948 32370 42501890
Hepatic necrosis 21.79 10.66 33 87042 3880 42530380
Synovitis 21.73 10.66 3 87072 15564 42518696
Stenotrophomonas infection 21.71 10.66 32 87043 3672 42530588
CD4 lymphocytes decreased 21.60 10.66 23 87052 1898 42532362
Swelling face 21.47 10.66 15 87060 27539 42506721
Sputum purulent 21.46 10.66 15 87060 697 42533563
Ocular icterus 21.45 10.66 29 87046 3072 42531188
Renal impairment 21.36 10.66 330 86745 109898 42424362
Obstructive airways disorder 21.33 10.66 12 87063 24747 42509513
Nosocomial infection 21.33 10.66 20 87055 1416 42532844
Lymphopenia 21.31 10.66 94 86981 21469 42512791
Vision blurred 21.23 10.66 49 87026 53650 42480610
Fluorosis 21.10 10.66 7 87068 56 42534204
Wound dehiscence 21.09 10.66 32 87043 3768 42530492
Arteriosclerosis coronary artery 21.06 10.66 6 87069 18671 42515589
Haematochezia 21.02 10.66 56 87019 58380 42475880
Swelling 20.97 10.66 51 87024 54834 42479426
Epstein-Barr virus infection 20.90 10.66 55 87020 9663 42524597
Back pain 20.89 10.66 187 86888 141589 42392671
Anterior displaced anus 20.78 10.66 4 87071 0 42534260
Arthritis fungal 20.66 10.66 8 87067 104 42534156
Mobility decreased 20.65 10.66 25 87050 35281 42498979
Myasthenia gravis 20.54 10.66 4 87071 16133 42518127
Syncope 20.52 10.66 119 86956 99287 42434973
Urinary tract inflammation 20.33 10.66 10 87065 238 42534022
Hepatocellular injury 20.29 10.66 99 86976 23579 42510681
Oral mucosal erythema 20.23 10.66 14 87061 640 42533620
Haemodynamic instability 20.17 10.66 64 87011 12493 42521767
Candida pneumonia 20.12 10.66 15 87060 771 42533489
Accidental overdose 20.06 10.66 17 87058 28313 42505947
Staphylococcal sepsis 20.03 10.66 60 87015 11354 42522906
Hepatic enzyme increased 19.99 10.66 161 86914 45623 42488637
Jaundice 19.93 10.66 130 86945 34459 42499801
Prostatic specific antigen increased 19.91 10.66 5 87070 16920 42517340
Transplant rejection 19.80 10.66 67 87008 13521 42520739
Fungal peritonitis 19.77 10.66 16 87059 929 42533331
Cholangitis infective 19.72 10.66 11 87064 341 42533919
Migraine 19.58 10.66 14 87061 25400 42508860
Anaphylactic reaction 19.44 10.66 36 87039 42707 42491553
Neonatal candida infection 19.43 10.66 6 87069 37 42534223
Cytopenia 19.40 10.66 79 86996 17418 42516842
Vertigo 19.38 10.66 25 87050 34322 42499938
COVID-19 19.32 10.66 148 86927 115800 42418460
Pleural effusion 19.25 10.66 292 86783 96874 42437386
Angioedema 19.12 10.66 36 87039 42441 42491819
Diabetic ketoacidosis 19.04 10.66 11 87064 22356 42511904
Frequent bowel movements 18.99 10.66 10 87065 21397 42512863
Drug ineffective for unapproved indication 18.91 10.66 160 86915 46003 42488257
Pulmonary fibrosis 18.91 10.66 16 87059 26665 42507595
Accidental exposure to product 18.88 10.66 9 87066 20384 42513876
Flushing 18.86 10.66 29 87046 36999 42497261
Hypercalcaemia 18.83 10.66 80 86995 17978 42516282
Pruritus 18.76 10.66 272 86803 188499 42345761
Nephrolithiasis 18.61 10.66 29 87046 36801 42497459
Wheezing 18.58 10.66 54 87021 54727 42479533
Irritability 18.58 10.66 18 87057 28110 42506150
Blast cell count increased 18.56 10.66 17 87058 1168 42533092
Pneumonia klebsiella 18.54 10.66 32 87043 4197 42530063
Graft versus host disease in skin 18.51 10.66 36 87039 5176 42529084
Gout 18.48 10.66 18 87057 28037 42506223
Pseudomonal sepsis 18.43 10.66 32 87043 4217 42530043
Balance disorder 18.42 10.66 44 87031 47601 42486659
Bladder cancer 18.28 10.66 6 87069 17041 42517219
Nasal congestion 18.22 10.66 20 87055 29481 42504779
Elbow synostosis 18.17 10.66 5 87070 19 42534241
Rhinorrhoea 18.09 10.66 23 87052 31771 42502489
Foetal exposure during pregnancy 18.05 10.66 44 87031 47267 42486993
Palpitations 18.02 10.66 49 87026 50748 42483512
Enterobacter test positive 18.01 10.66 9 87066 222 42534038
Incorrect route of product administration 17.94 10.66 14 87061 24291 42509969
Joint injury 17.93 10.66 4 87071 14672 42519588
Sleep apnoea syndrome 17.87 10.66 11 87064 21597 42512663
Lung infiltration 17.83 10.66 66 87009 13923 42520337
Mycotic endophthalmitis 17.82 10.66 9 87066 227 42534033
Dermatitis exfoliative 17.77 10.66 42 87033 6905 42527355
Klebsiella bacteraemia 17.73 10.66 23 87052 2341 42531919
Pleocytosis 17.72 10.66 13 87062 652 42533608
Heart rate increased 17.70 10.66 53 87022 53202 42481058
Hot flush 17.63 10.66 12 87063 22339 42511921
Citrobacter infection 17.55 10.66 13 87062 662 42533598
Choreoathetosis 17.54 10.66 16 87059 1093 42533167
Mycobacterium avium complex infection 17.53 10.66 26 87049 3001 42531259
Therapy cessation 17.49 10.66 10 87065 20440 42513820
Therapy interrupted 17.48 10.66 12 87063 22238 42512022
Congenital foot malformation 17.47 10.66 11 87064 428 42533832
Synostosis 17.42 10.66 7 87068 101 42534159
Respiratory tract infection fungal 17.41 10.66 14 87061 805 42533455
Infective keratitis 17.37 10.66 6 87069 55 42534205
Type 2 diabetes mellitus 17.33 10.66 8 87067 18463 42515797
Enterovirus infection 17.29 10.66 17 87058 1276 42532984
Malignant neoplasm progression 17.29 10.66 140 86935 108260 42426000
Gastrooesophageal reflux disease 17.07 10.66 42 87033 44981 42489279
Skin necrosis 17.05 10.66 39 87036 6275 42527985
Colitis ulcerative 17.00 10.66 17 87058 26158 42508102
Mucosal infection 17.00 10.66 9 87066 251 42534009
Immune reconstitution inflammatory syndrome associated tuberculosis 16.95 10.66 12 87063 569 42533691
Engraft failure 16.91 10.66 12 87063 571 42533689
Central venous pressure increased 16.91 10.66 5 87070 26 42534234
Neutropenic sepsis 16.90 10.66 71 87004 15875 42518385
Contraindicated product administered 16.89 10.66 16 87059 25256 42509004
Glycosylated haemoglobin increased 16.88 10.66 3 87072 12921 42521339
Medication error 16.85 10.66 26 87049 33128 42501132
Prothrombin time prolonged 16.83 10.66 50 87025 9419 42524841
Road traffic accident 16.81 10.66 9 87066 19084 42515176
Paraesthesia 16.78 10.66 85 86990 73374 42460886
Muscle spasms 16.71 10.66 105 86970 85939 42448321
Liver transplant rejection 16.63 10.66 23 87052 2490 42531770
Injection site swelling 16.48 10.66 7 87068 16966 42517294
Mediastinitis 16.38 10.66 15 87060 1030 42533230
Eschar 16.35 10.66 13 87062 736 42533524
Disseminated mucormycosis 16.25 10.66 17 87058 1374 42532886
Hepatomegaly 16.21 10.66 57 87018 11728 42522532
Adenovirus infection 16.16 10.66 40 87035 6769 42527491
Respiratory distress 16.11 10.66 143 86932 41677 42492583
Chorioretinitis 16.06 10.66 12 87063 619 42533641
Hepatitis 15.97 10.66 103 86972 27197 42507063
Pseudomonal bacteraemia 15.96 10.66 22 87053 2374 42531886
Oral mucosa erosion 15.89 10.66 15 87060 1071 42533189
Device malfunction 15.80 10.66 3 87072 12324 42521936
Psychotic disorder 15.73 10.66 22 87053 29186 42505074
Sleep disorder due to a general medical condition 15.71 10.66 8 87067 17445 42516815
Anticonvulsant drug level abnormal 15.65 10.66 5 87070 35 42534225
Obesity 15.64 10.66 7 87068 16452 42517808
Anaphylactic shock 15.59 10.66 15 87060 23502 42510758
Blood cholesterol increased 15.57 10.66 19 87056 26722 42507538
Hypokalaemia 15.57 10.66 219 86856 71502 42462758
Unevaluable event 15.48 10.66 29 87046 34259 42500001
Adrenal suppression 15.42 10.66 14 87061 951 42533309
Osteonecrosis of jaw 15.33 10.66 10 87065 19039 42515221
Blood glucose increased 15.33 10.66 88 86987 73611 42460649
Neutropenic infection 15.28 10.66 19 87056 1854 42532406
Meningitis coccidioides 15.26 10.66 4 87071 12 42534248
Dyspnoea exertional 15.20 10.66 52 87023 50096 42484164
Platelet transfusion 15.14 10.66 18 87057 1676 42532584
Anger 15.02 10.66 4 87071 13014 42521246
Asthenia 14.99 10.66 448 86627 280345 42253915
Hypertransaminasaemia 14.79 10.66 47 87028 9180 42525080
Metastases to bone 14.55 10.66 6 87069 14803 42519457
Contusion 14.52 10.66 41 87034 41944 42492316
Flatulence 14.51 10.66 18 87057 25134 42509126
Fungal endocarditis 14.51 10.66 10 87065 454 42533806
Periostitis 14.49 10.66 9 87066 342 42533918
Cytomegalovirus infection reactivation 14.46 10.66 53 87022 11125 42523135
Cytomegalovirus test 14.46 10.66 5 87070 46 42534214
Cerebral aspergillosis 14.45 10.66 18 87057 1759 42532501
Haemodialysis 14.43 10.66 50 87025 10210 42524050
Delusion 14.43 10.66 6 87069 14728 42519532
HIV associated nephropathy 14.42 10.66 9 87066 345 42533915
Cryptococcal cutaneous infection 14.41 10.66 7 87068 162 42534098
Bone marrow disorder 14.39 10.66 19 87056 1967 42532293
Influenza like illness 14.32 10.66 27 87048 31813 42502447
Brachycephaly 14.31 10.66 6 87069 97 42534163
Bacillus infection 14.29 10.66 12 87063 734 42533526
Bradycardia 14.29 10.66 109 86966 85375 42448885
Dermatitis 14.28 10.66 55 87020 11820 42522440
Opportunistic infection 14.28 10.66 19 87056 1982 42532278
Depressed mood 14.28 10.66 16 87059 23368 42510892
Weight decreased 14.22 10.66 320 86755 207628 42326632
Organ failure 14.19 10.66 21 87054 2419 42531841
Diffuse large B-cell lymphoma 14.12 10.66 47 87028 9407 42524853
Application site haematoma 14.09 10.66 5 87070 50 42534210
Diplegia 13.99 10.66 15 87060 1247 42533013
Oesophagitis 13.97 10.66 65 87010 15182 42519078
Bacterial diarrhoea 13.96 10.66 7 87068 174 42534086
Oedema 13.90 10.66 165 86910 51836 42482424
Blood creatinine increased 13.85 10.66 308 86767 109695 42424565
Pseudomonas test positive 13.83 10.66 16 87059 1447 42532813
Bacterial infection 13.82 10.66 101 86974 27778 42506482
Hyperthyroidism 13.79 10.66 6 87069 14335 42519925
Constipation 13.73 10.66 241 86834 162050 42372210
Cardiogenic shock 13.71 10.66 33 87042 35607 42498653
Inhibitory drug interaction 13.69 10.66 18 87057 1856 42532404
Acute encephalitis with refractory, repetitive partial seizures 13.67 10.66 5 87070 55 42534205
Multiple sclerosis relapse 13.66 10.66 6 87069 14258 42520002
Peritoneal candidiasis 13.66 10.66 4 87071 20 42534240
Culture stool positive 13.62 10.66 8 87067 274 42533986
Product quality issue 13.58 10.66 10 87065 17872 42516388
Secondary adrenocortical insufficiency 13.57 10.66 19 87056 2080 42532180
Hyperadrenocorticism 13.50 10.66 7 87068 187 42534073
Streptococcal infection 13.49 10.66 35 87040 6097 42528163
Myelodysplastic syndrome 13.42 10.66 86 86989 22659 42511601
Nervous system disorder 13.40 10.66 70 87005 17125 42517135
Benign prostatic hyperplasia 13.30 10.66 14 87061 21038 42513222
Malassezia infection 13.28 10.66 5 87070 60 42534200
Throat irritation 13.27 10.66 5 87070 13031 42521229
Illness 13.20 10.66 19 87056 24911 42509349
Gallbladder fistula 13.19 10.66 4 87071 23 42534237
Erectile dysfunction 13.18 10.66 19 87056 24894 42509366
Haemoglobin decreased 13.12 10.66 359 86716 132112 42402148
Thrombosis 13.10 10.66 84 86991 68427 42465833
Acute generalised exanthematous pustulosis 13.07 10.66 43 87032 8552 42525708
Lung disorder 13.01 10.66 52 87023 47871 42486389
Meningism 13.01 10.66 7 87068 202 42534058
Product administration error 13.00 10.66 11 87064 18332 42515928
Iatrogenic infection 12.98 10.66 5 87070 64 42534196
Sputum culture positive 12.96 10.66 17 87058 1749 42532511
Rectal perforation 12.95 10.66 10 87065 542 42533718
Dysarthria 12.95 10.66 40 87035 39767 42494493
Pruritus genital 12.95 10.66 21 87054 2618 42531642
Coronary artery disease 12.94 10.66 61 87014 53659 42480601
Drug withdrawal syndrome 12.88 10.66 15 87060 21534 42512726
Cytomegalovirus enterocolitis 12.87 10.66 15 87060 1368 42532892
Dystonia 12.86 10.66 5 87070 12785 42521475
Full blood count abnormal 12.86 10.66 26 87049 29850 42504410
Escherichia sepsis 12.85 10.66 33 87042 5714 42528546
Disturbance in attention 12.84 10.66 26 87049 29840 42504420
Herpes zoster reactivation 12.84 10.66 9 87066 420 42533840
Injection site haemorrhage 12.82 10.66 4 87071 11732 42522528
Dementia 12.80 10.66 9 87066 16471 42517789
Infective corneal ulcer 12.78 10.66 4 87071 26 42534234
Peritonitis bacterial 12.75 10.66 37 87038 6878 42527382
Myalgia 12.75 10.66 130 86945 95950 42438310
Spinal cord injury thoracic 12.59 10.66 6 87069 133 42534127
Faeces pale 12.57 10.66 16 87059 1598 42532662
Capillary leak syndrome 12.55 10.66 21 87054 2686 42531574
CD4/CD8 ratio decreased 12.52 10.66 4 87071 28 42534232
Anaemia 12.52 10.66 696 86379 279582 42254678
Injection site bruising 12.46 10.66 4 87071 11521 42522739
Neonatal cholestasis 12.45 10.66 5 87070 72 42534188
End stage AIDS 12.40 10.66 4 87071 29 42534231
Basal cell carcinoma 12.36 10.66 17 87058 22716 42511544
Pneumonitis 12.33 10.66 135 86940 41583 42492677
Dry mouth 12.33 10.66 41 87034 39838 42494422
Enterobacter infection 12.23 10.66 22 87053 2982 42531278
Toxic skin eruption 12.19 10.66 58 87017 13672 42520588
Xerosis 12.17 10.66 12 87063 904 42533356
Productive cough 12.16 10.66 59 87016 51508 42482752
No adverse event 12.14 10.66 40 87035 38981 42495279
Renal ischaemia 12.14 10.66 16 87059 1654 42532606
Chronic lymphocytic leukaemia 12.14 10.66 29 87046 4800 42529460
Endocarditis candida 12.09 10.66 5 87070 78 42534182
ADAMTS13 activity decreased 12.08 10.66 6 87069 146 42534114
Hypertensive crisis 12.04 10.66 3 87072 10203 42524057
HIV wasting syndrome 12.03 10.66 5 87070 79 42534181
Viral test positive 12.02 10.66 7 87068 236 42534024
Abdominal compartment syndrome 12.02 10.66 13 87062 1092 42533168
Myelosuppression 11.99 10.66 131 86944 40330 42493930
Speech disorder 11.98 10.66 26 87049 29095 42505165
Presyncope 11.92 10.66 17 87058 22370 42511890
Necrotising colitis 11.83 10.66 14 87061 1297 42532963
Pneumonia pseudomonal 11.82 10.66 29 87046 4880 42529380
Interstitial lung disease 11.76 10.66 103 86972 78359 42455901
Abdominal distension 11.74 10.66 92 86983 71643 42462617
Neuroleptic malignant syndrome 11.73 10.66 16 87059 21456 42512804
Scopulariopsis infection 11.72 10.66 6 87069 156 42534104
Disseminated aspergillosis 11.70 10.66 16 87059 1714 42532546
Generalised oedema 11.65 10.66 62 87013 15274 42518986
Lymphocyte adoptive therapy 11.65 10.66 5 87070 86 42534174
Pulmonary embolism 11.65 10.66 173 86902 119439 42414821
Appendicitis 11.63 10.66 15 87060 20598 42513662
Blood alkaline phosphatase abnormal 11.63 10.66 10 87065 632 42533628
Immunodeficiency 11.57 10.66 37 87038 7253 42527007
Laryngitis fungal 11.55 10.66 4 87071 37 42534223
Poisoning 11.45 10.66 8 87067 14691 42519569
Movement disorder 11.45 10.66 8 87067 14690 42519570
Familial periodic paralysis 11.41 10.66 6 87069 165 42534095
Monocytopenia 11.39 10.66 5 87070 91 42534169
Feeling hot 11.38 10.66 19 87056 23463 42510797
Eyelid ptosis congenital 11.34 10.66 5 87070 92 42534168
Neuralgia 11.31 10.66 22 87053 25625 42508635
Limb discomfort 11.27 10.66 6 87069 12761 42521499
Infectious pleural effusion 11.26 10.66 22 87053 3173 42531087
Gastrointestinal fungal infection 11.17 10.66 7 87068 270 42533990
Lip injury 11.15 10.66 7 87068 271 42533989
Secondary syphilis 11.15 10.66 5 87070 96 42534164
Pulmonary nocardiosis 11.12 10.66 16 87059 1796 42532464
Metabolic acidosis 11.11 10.66 158 86917 51700 42482560
Injection site erythema 11.09 10.66 15 87060 20180 42514080
Bone marrow transplant 11.06 10.66 13 87062 1196 42533064
Hypoperfusion 11.06 10.66 14 87061 1391 42532869
Septic embolus 11.06 10.66 14 87061 1391 42532869
Procalcitonin increased 11.02 10.66 18 87057 2258 42532002
Gynaecomastia 10.95 10.66 6 87069 12561 42521699
Visual impairment 10.95 10.66 48 87027 43065 42491195
Epstein-Barr viraemia 10.94 10.66 18 87057 2271 42531989
Haematotoxicity 10.94 10.66 48 87027 10937 42523323
Human herpesvirus 6 infection 10.93 10.66 19 87056 2506 42531754
T-cell lymphoma recurrent 10.93 10.66 4 87071 44 42534216
Transient ischaemic attack 10.91 10.66 34 87041 33705 42500555
Unmasking of previously unidentified disease 10.89 10.66 13 87062 1216 42533044
Serum ferritin increased 10.88 10.66 36 87039 7183 42527077
Dermatitis bullous 10.86 10.66 40 87035 8416 42525844
Adult T-cell lymphoma/leukaemia 10.82 10.66 6 87069 184 42534076
Mania 10.81 10.66 4 87071 10543 42523717
Haemorrhagic necrotic pancreatitis 10.79 10.66 6 87069 185 42534075
Erythroblast count increased 10.78 10.66 3 87072 12 42534248
Musculoskeletal discomfort 10.77 10.66 3 87072 9473 42524787
Lung neoplasm malignant 10.74 10.66 14 87061 19133 42515127
Skin cancer 10.70 10.66 5 87070 11457 42522803

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1239.93 10.04 1993 176023 314774 110096509
Drug interaction 797.88 10.04 2176 175840 498007 109913276
Candida infection 695.46 10.04 594 177422 47415 110363868
Mucosal inflammation 506.01 10.04 696 177320 95445 110315838
Pancytopenia 477.43 10.04 1047 176969 208566 110202717
Cytokine release syndrome 463.68 10.04 569 177447 69737 110341546
Immune reconstitution inflammatory syndrome 463.56 10.04 302 177714 15924 110395359
Mucormycosis 437.74 10.04 250 177766 10378 110400905
Thrombocytopenia 420.57 10.04 1376 176640 347509 110063774
Multiple organ dysfunction syndrome 414.76 10.04 817 177199 150893 110260390
Pyrexia 406.04 10.04 2651 175365 895614 109515669
Aplastic anaemia 383.43 10.04 316 177700 23992 110387291
Sepsis 373.06 10.04 1267 176749 326079 110085204
Fungal infection 349.30 10.04 420 177596 50386 110360897
Neutropenia 345.81 10.04 1354 176662 373266 110038017
Pathogen resistance 343.89 10.04 260 177756 17412 110393871
Synovitis 339.26 10.04 27 177989 274065 110137218
Septic shock 335.15 10.04 766 177250 156762 110254521
Hand deformity 325.80 10.04 5 178011 218501 110192782
Aspergillus infection 321.00 10.04 292 177724 25324 110385959
Completed suicide 317.18 10.04 18 177998 242363 110168920
Platelet count decreased 310.57 10.04 945 177071 229498 110181785
Systemic lupus erythematosus 309.41 10.04 27 177989 254311 110156972
Pemphigus 296.79 10.04 11 178005 214559 110196724
Arthralgia 279.25 10.04 519 177497 779113 109632170
Graft versus host disease 274.94 10.04 234 177782 18572 110392711
Glossodynia 271.58 10.04 23 177993 221981 110189302
Arthropathy 270.68 10.04 65 177951 287457 110123826
Cytomegalovirus infection 268.26 10.04 382 177634 54062 110357221
Drug resistance 268.19 10.04 389 177627 55985 110355298
Stevens-Johnson syndrome 264.09 10.04 351 177665 46550 110364733
Duodenal ulcer perforation 249.65 10.04 8 178008 177692 110233591
Toxic epidermal necrolysis 249.11 10.04 377 177639 56350 110354933
Meningitis cryptococcal 245.71 10.04 130 177886 4632 110406651
Helicobacter infection 242.66 10.04 12 178004 181865 110229418
Wound 241.29 10.04 43 177973 234394 110176889
Abdominal discomfort 231.75 10.04 177 177839 393681 110017602
Pericarditis 221.61 10.04 42 177974 219072 110192211
Therapeutic product effect decreased 215.21 10.04 63 177953 244253 110167030
Neutrophil count decreased 215.21 10.04 549 177467 120392 110290891
Foetal death 209.10 10.04 187 177829 15858 110395425
Systemic candida 208.03 10.04 153 177863 9821 110401462
Bronchopulmonary aspergillosis 207.09 10.04 248 177768 29615 110381668
Enterococcal infection 205.49 10.04 206 177810 20160 110391123
Oral candidiasis 204.42 10.04 303 177713 44457 110366826
Swelling 198.64 10.04 164 177852 350877 110060406
Type 2 diabetes mellitus 190.18 10.04 29 177987 177203 110234080
Musculoskeletal stiffness 189.96 10.04 107 177909 279715 110131568
Impaired healing 188.01 10.04 43 177973 196674 110214609
Irritable bowel syndrome 187.81 10.04 22 177994 164193 110247090
Peripheral swelling 186.00 10.04 226 177790 403808 110007475
Nasopharyngitis 184.29 10.04 218 177798 394143 110017140
Torsade de pointes 184.18 10.04 204 177812 22396 110388887
Acute myeloid leukaemia 181.29 10.04 263 177753 37847 110373436
Fibromyalgia 178.80 10.04 30 177986 170879 110240404
Folliculitis 178.60 10.04 28 177988 167625 110243658
Psoriatic arthropathy 176.48 10.04 49 177967 196712 110214571
Cryptococcosis 174.95 10.04 103 177913 4528 110406755
Fall 170.56 10.04 457 177559 603025 109808258
Temperature regulation disorder 168.16 10.04 150 177866 12676 110398607
Joint swelling 168.00 10.04 284 177732 442561 109968722
Drug abuse 155.75 10.04 46 177970 177365 110233918
Alopecia 154.53 10.04 217 177799 364536 110046747
Mobility decreased 153.78 10.04 96 177920 237326 110173957
Respiratory failure 149.70 10.04 715 177301 214617 110196666
Pseudomonas infection 148.48 10.04 203 177813 27650 110383633
Immune effector cell-associated neurotoxicity syndrome 148.18 10.04 149 177867 14633 110396650
Immunosuppressant drug level increased 143.66 10.04 132 177884 11592 110399691
Drug reaction with eosinophilia and systemic symptoms 143.25 10.04 370 177646 81725 110329558
Blood cholesterol increased 143.16 10.04 59 177957 184726 110226557
Maternal exposure during pregnancy 143 10.04 120 177896 254763 110156520
Neurotoxicity 142.44 10.04 249 177767 41958 110369325
Food allergy 140.51 10.04 167 177849 19781 110391502
White blood cell count decreased 136.48 10.04 729 177287 228661 110182622
Drug level increased 135.15 10.04 261 177755 47458 110363825
Intentional overdose 134.79 10.04 25 177991 132476 110278807
Drug ineffective for unapproved indication 132.13 10.04 415 177601 102423 110308860
Immunodeficiency 130.90 10.04 229 177787 38609 110372674
Cytomegalovirus viraemia 130.58 10.04 152 177864 17612 110393671
Female genital tract fistula 129.28 10.04 146 177870 16373 110394910
Electrocardiogram QT prolonged 127.61 10.04 426 177590 108534 110302749
C-reactive protein abnormal 126.64 10.04 27 177989 129668 110281615
Intentional product use issue 125.72 10.04 128 177888 247778 110163505
Tumour lysis syndrome 123.05 10.04 196 177820 30605 110380678
Staphylococcal infection 122.82 10.04 316 177700 69628 110341655
Dizziness 121.93 10.04 644 177372 697549 109713734
Fungaemia 121.64 10.04 91 177925 5995 110405288
Systemic mycosis 121.10 10.04 76 177940 3753 110407530
Peripheral venous disease 121.02 10.04 3 178013 84114 110327169
Lip dry 120.64 10.04 11 178005 100072 110311211
Suicide attempt 120.35 10.04 13 178003 103381 110307902
Acute graft versus host disease 120.33 10.04 125 177891 12756 110398527
Sleep disorder 119.67 10.04 87 177929 198557 110212726
Ill-defined disorder 116.86 10.04 53 177963 156800 110254483
Vaginal discharge 113.29 10.04 142 177874 17766 110393517
Plasma cell myeloma 113.26 10.04 287 177729 62649 110348634
Disseminated mucormycosis 113.05 10.04 59 177957 2043 110409240
Leukopenia 111.42 10.04 505 177511 148286 110262997
Rash erythematous 111.41 10.04 337 177679 81495 110329788
Contusion 108.94 10.04 129 177887 233232 110178051
Acute kidney injury 106.45 10.04 1522 176494 633908 109777375
Discomfort 106.44 10.04 113 177903 214594 110196689
Chronic sinusitis 106.28 10.04 164 177852 24920 110386363
Memory impairment 105.29 10.04 97 177919 196847 110214436
Disseminated intravascular coagulation 105.12 10.04 216 177800 41070 110370213
Blood bilirubin increased 103.55 10.04 313 177703 75659 110335624
Acute graft versus host disease in skin 103.53 10.04 106 177910 10634 110400649
Bacteraemia 103.51 10.04 218 177798 42172 110369111
Musculoskeletal pain 102.84 10.04 86 177930 182937 110228346
Dry mouth 101.64 10.04 103 177913 199845 110211438
Blood lactate dehydrogenase increased 101.37 10.04 222 177794 44112 110367171
Bone marrow failure 101.20 10.04 261 177755 57587 110353696
Joint range of motion decreased 100.87 10.04 35 177981 121797 110289486
Alanine aminotransferase increased 100.54 10.04 571 177445 183202 110228081
Agranulocytosis 100.26 10.04 271 177745 61489 110349794
Obesity 100.19 10.04 29 177987 113322 110297961
Weight increased 99 10.04 345 177671 419299 109991984
Fatigue 98.82 10.04 1372 176644 1214586 109196697
Drug ineffective 97.35 10.04 3164 174852 1517376 108893907
Night sweats 97.14 10.04 47 177969 133936 110277347
Wheezing 96.41 10.04 164 177852 255066 110156217
Dysbiosis 95.51 10.04 53 177963 2079 110409204
Clostridium difficile colitis 93.13 10.04 213 177803 43565 110367718
Haemophagocytic lymphohistiocytosis 92.30 10.04 175 177841 31384 110379899
Road traffic accident 92.16 10.04 29 177987 107369 110303914
Klebsiella infection 90.70 10.04 135 177881 19874 110391409
Oesophageal candidiasis 90.36 10.04 102 177914 11432 110399851
Grip strength decreased 88.59 10.04 12 178004 80162 110331121
Osteoarthritis 87.33 10.04 99 177917 182524 110228759
Dyspnoea 87.00 10.04 1257 176759 1105615 109305668
Inflammation 86.83 10.04 110 177906 193128 110218155
Anaemia 85.88 10.04 1296 176720 545790 109865493
Live birth 85.48 10.04 7 178009 69477 110341806
Bacterial sepsis 84.76 10.04 94 177922 10332 110400951
Gastrointestinal disorder 84.64 10.04 163 177853 241789 110169494
Hepatotoxicity 84.34 10.04 259 177757 63141 110348142
Lower limb fracture 83.92 10.04 11 178005 75337 110335946
Sinusitis fungal 83.55 10.04 53 177963 2667 110408616
Lung disorder 82.45 10.04 101 177915 179946 110231337
Aspartate aminotransferase increased 82.31 10.04 489 177527 159447 110251836
Renal failure 82.03 10.04 635 177381 225939 110185344
Candida sepsis 81.85 10.04 54 177962 2907 110408376
Wound infection 81.09 10.04 27 177989 96438 110314845
Hyperbilirubinaemia 81.09 10.04 163 177853 30508 110380775
Salpingo-oophorectomy unilateral 80.60 10.04 35 177981 796 110410487
Rash maculo-papular 80.59 10.04 283 177733 73939 110337344
Abdominal pain upper 80.32 10.04 290 177726 348821 110062462
Pain in extremity 80.16 10.04 458 177558 486660 109924623
Pulmonary fibrosis 79.96 10.04 32 177984 102010 110309273
Fixed eruption 77.36 10.04 60 177956 4172 110407111
Acinetobacter infection 77.21 10.04 56 177960 3517 110407766
Rheumatoid arthritis 77.07 10.04 237 177779 299376 110111907
Vaginal flatulence 76.35 10.04 96 177920 12048 110399235
Pneumonia fungal 76.33 10.04 106 177910 14648 110396635
Cystitis haemorrhagic 75.94 10.04 96 177920 12113 110399170
Mouth ulceration 75.91 10.04 209 177807 47929 110363354
Insomnia 75.58 10.04 311 177705 360279 110051004
Venoocclusive liver disease 75.33 10.04 107 177909 15100 110396183
Device related infection 75.08 10.04 184 177832 39335 110371948
Disseminated cryptococcosis 74.77 10.04 49 177967 2608 110408675
Cholestasis 74.41 10.04 251 177765 64267 110347016
Injection site pain 74.14 10.04 107 177909 177815 110233468
Deep vein thrombosis 73.46 10.04 430 177586 139457 110271826
Graft versus host disease in gastrointestinal tract 73.15 10.04 81 177935 8887 110402396
Hepatic failure 72.83 10.04 260 177756 68479 110342804
Hypercholesterolaemia 71.98 10.04 28 177988 90809 110320474
Blepharospasm 71.94 10.04 4 178012 54847 110356436
Loss of personal independence in daily activities 70.99 10.04 82 177934 149938 110261345
Proctitis 70.77 10.04 110 177906 16817 110394466
Contraindicated product administered 70.75 10.04 187 177829 248080 110163203
Hepatic function abnormal 70.54 10.04 308 177708 88987 110322296
Epstein-Barr virus infection 69.09 10.04 115 177901 18623 110392660
Migraine 68.83 10.04 106 177910 171546 110239737
Arthritis 68.64 10.04 102 177914 167484 110243799
Gait inability 68.44 10.04 71 177945 136305 110274978
International normalised ratio increased 68.32 10.04 299 177717 86473 110324810
Blood alkaline phosphatase increased 68.19 10.04 260 177756 70675 110340608
Neutropenic sepsis 68.08 10.04 152 177864 30594 110380689
Chronic graft versus host disease 67.97 10.04 80 177936 9377 110401906
Pain 67.95 10.04 1105 176911 953850 109457433
Gastrointestinal mucormycosis 67.94 10.04 30 177986 711 110410572
Inappropriate schedule of product administration 67.94 10.04 141 177875 203496 110207787
Pneumonia cryptococcal 66.99 10.04 45 177971 2497 110408786
Renal impairment 66.46 10.04 525 177491 187920 110223363
Disseminated coccidioidomycosis 65.92 10.04 22 177994 234 110411049
Skin candida 65.68 10.04 43 177973 2285 110408998
Acute myeloid leukaemia recurrent 65.19 10.04 59 177957 5080 110406203
Paraesthesia 64.72 10.04 228 177788 276293 110134990
Laryngitis fungal 63.92 10.04 20 177996 170 110411113
Pneumonia 62.88 10.04 1851 176165 874863 109536420
Cerebral toxoplasmosis 62.84 10.04 47 177969 3095 110408188
Geotrichum infection 62.28 10.04 33 177983 1179 110410104
Cytomegalovirus test positive 61.66 10.04 66 177950 6970 110404313
Malaise 61.39 10.04 739 177277 671080 109740203
Autoimmune disorder 61.18 10.04 15 178001 65468 110345815
Coagulopathy 60.95 10.04 174 177842 40737 110370546
Encephalitis 60.79 10.04 109 177907 18730 110392553
Muscle spasms 60.10 10.04 237 177779 277920 110133363
Adverse event 60.04 10.04 52 177964 108757 110302526
Staphylococcal bacteraemia 59.64 10.04 101 177915 16587 110394696
Bone erosion 58.95 10.04 4 178012 46367 110364916
Radiculopathy 58.76 10.04 109 177907 19227 110392056
Swollen tongue 58.64 10.04 222 177794 60140 110351143
Hypoaesthesia 58.61 10.04 283 177733 313940 110097343
Acute generalised exanthematous pustulosis 58.31 10.04 116 177900 21548 110389735
Gait disturbance 58.25 10.04 240 177776 277968 110133315
Onychomadesis 57.87 10.04 4 178012 45659 110365624
Blood pressure increased 57.20 10.04 218 177798 258155 110153128
General physical health deterioration 57.17 10.04 425 177591 424870 109986413
Product dose omission issue 57.04 10.04 295 177721 321487 110089796
Colitis 56.64 10.04 319 177697 102004 110309279
Oropharyngeal candidiasis 56.13 10.04 37 177979 1989 110409294
Hepatic cirrhosis 54.99 10.04 20 177996 67606 110343677
Stenotrophomonas infection 54.99 10.04 57 177959 5801 110405482
Knee arthroplasty 54.90 10.04 18 177998 64930 110346353
Graft versus host disease in skin 54.70 10.04 67 177949 8187 110403096
Gamma-glutamyltransferase increased 54.29 10.04 219 177797 61090 110350193
Dermatitis bullous 53.50 10.04 99 177917 17430 110393853
Toxic neuropathy 53.29 10.04 29 177987 1094 110410189
Pleural effusion 53.06 10.04 477 177539 177232 110234051
Cytomegalovirus infection reactivation 52.79 10.04 101 177915 18232 110393051
Medication error 52.71 10.04 55 177961 105311 110305972
Urticaria 52.29 10.04 300 177716 318557 110092726
Nocardiosis 51.62 10.04 62 177954 7424 110403859
Blister 51.53 10.04 190 177826 227186 110184097
Hypokalaemia 50.58 10.04 482 177534 181966 110229317
Transplant rejection 50.56 10.04 118 177898 24449 110386834
Pulmonary haemorrhage 50.30 10.04 93 177923 16363 110394920
Brain abscess 49.85 10.04 58 177958 6716 110404567
Systemic inflammatory response syndrome 49.37 10.04 81 177935 12962 110398321
HIV infection 49.27 10.04 29 177987 1274 110410009
Embolism venous 49.19 10.04 50 177966 4973 110406310
Long QT syndrome 49.16 10.04 59 177957 7059 110404224
Exostosis 48.19 10.04 8 178008 45948 110365335
Back injury 48.07 10.04 9 178007 47390 110363893
Coccidioidomycosis 48.06 10.04 31 177985 1606 110409677
Acute respiratory distress syndrome 47.89 10.04 191 177825 53007 110358276
Lymphopenia 47.85 10.04 158 177858 40012 110371271
Sciatica 47.62 10.04 47 177969 92352 110318931
Red blood cell sedimentation rate increased 47.52 10.04 34 177982 78268 110333015
Odynophagia 47.32 10.04 83 177933 14018 110397265
Dysphagia 47.25 10.04 415 177601 153185 110258098
Hip arthroplasty 46.25 10.04 16 178000 55797 110355486
Stress 46.24 10.04 61 177955 105287 110305996
Uterine perforation 46.10 10.04 56 177960 6784 110404499
Engraftment syndrome 45.71 10.04 32 177984 1900 110409383
Lupus-like syndrome 45.32 10.04 6 178010 40786 110370497
Eosinophilia 45.12 10.04 199 177817 57737 110353546
Erythema 45.09 10.04 689 177327 290758 110120525
Product quality issue 45.06 10.04 35 177981 77264 110334019
Septic embolus 44.76 10.04 34 177982 2292 110408991
Pseudomembranous colitis 44.18 10.04 53 177963 6338 110404945
Lymphocyte count decreased 44.11 10.04 196 177820 57047 110354236
Enterococcal sepsis 43.94 10.04 39 177977 3273 110408010
Joint stiffness 43.77 10.04 27 177989 67216 110344067
Respiratory tract infection fungal 43.69 10.04 27 177989 1297 110409986
Foot deformity 43.58 10.04 12 178004 48468 110362815
Dysphonia 43.54 10.04 239 177777 75690 110335593
Wrong technique in product usage process 43.23 10.04 46 177970 87302 110323981
Hypertension 43.22 10.04 570 177446 509514 109901769
Infective aneurysm 43.17 10.04 28 177988 1464 110409819
Enterococcal bacteraemia 42.95 10.04 44 177972 4417 110406866
Adverse drug reaction 42.49 10.04 65 177951 105494 110305789
Infusion related reaction 42.14 10.04 401 177615 380761 110030522
Injection site erythema 41.88 10.04 54 177962 94122 110317161
Drug intolerance 41.88 10.04 435 177581 406077 110005206
Feeling hot 41.81 10.04 51 177965 91055 110320228
Staphylococcal sepsis 41.73 10.04 89 177927 17365 110393918
Cachexia 41.65 10.04 75 177941 12930 110398353
Nervous system disorder 41.63 10.04 129 177887 31592 110379691
Fusarium infection 41.57 10.04 35 177981 2736 110408547
Enterobacter infection 41.50 10.04 49 177967 5762 110405521
Stem cell transplant 41.42 10.04 43 177973 4384 110406899
Aplasia 41.38 10.04 57 177959 7816 110403467
Injection site swelling 41.36 10.04 24 177992 61766 110349517
Macular degeneration 41.31 10.04 101 177915 21558 110389725
Nephropathy toxic 41.06 10.04 117 177899 27361 110383922
Blast cell count increased 40.81 10.04 28 177988 1609 110409674
Liver injury 40.81 10.04 116 177900 150297 110260986
Underdose 40.70 10.04 26 177990 63528 110347755
Penis injury 40.69 10.04 13 178003 119 110411164
Joint dislocation 40.56 10.04 4 178012 34186 110377097
Coeliac disease 40.44 10.04 157 177859 43030 110368253
Depression 40.33 10.04 322 177694 317013 110094270
Constipation 40.30 10.04 804 177212 356982 110054301
Cytopenia 40.02 10.04 123 177893 29993 110381290
Jaundice 39.89 10.04 195 177821 59041 110352242
Gastrointestinal fungal infection 39.44 10.04 21 177995 758 110410525
Fungal sepsis 39.34 10.04 31 177985 2206 110409077
Intracranial pressure increased 39.30 10.04 65 177951 10470 110400813
Swelling face 39.27 10.04 269 177747 92052 110319231
Trichosporon infection 39.11 10.04 25 177991 1275 110410008
Cutaneous coccidioidomycosis 39.04 10.04 9 178007 18 110411265
Toxic skin eruption 39.03 10.04 115 177901 27400 110383883
Toxoplasmosis 38.78 10.04 36 177980 3203 110408080
Erythema multiforme 38.78 10.04 97 177919 21000 110390283
Myocardial infarction 38.77 10.04 168 177848 191915 110219368
Lower respiratory tract infection 38.63 10.04 231 177785 242875 110168408
Encephalopathy 38.63 10.04 243 177773 80812 110330471
Blood culture positive 38.46 10.04 59 177957 8917 110402366
Vaginal infection 38.41 10.04 51 177965 6753 110404530
Taste disorder 37.61 10.04 30 177986 65357 110345926
Sedation 37.60 10.04 34 177982 69649 110341634
Hypomagnesaemia 37.32 10.04 194 177822 60176 110351107
Asthenia 37.28 10.04 835 177181 688164 109723119
Fungal test positive 37.23 10.04 23 177993 1104 110410179
Blood creatinine increased 37.13 10.04 454 177562 182435 110228848
Retinitis viral 37.05 10.04 17 177999 442 110410841
Pruritus 37.05 10.04 686 177330 580874 109830409
Multiple-drug resistance 36.99 10.04 72 177944 13163 110398120
Acute lymphocytic leukaemia 36.92 10.04 46 177970 5719 110405564
Rhinorrhoea 36.90 10.04 68 177948 102598 110308685
Hepatitis cholestatic 36.84 10.04 85 177931 17481 110393802
Injection site reaction 36.67 10.04 54 177962 89016 110322267
Myelodysplastic syndrome 36.52 10.04 138 177878 37346 110373937
Vulvovaginal candidiasis 36.44 10.04 35 177981 3250 110408033
Blood pressure fluctuation 36.37 10.04 40 177976 74784 110336499
Haemodialysis 36.35 10.04 85 177931 17634 110393649
Toxicity to various agents 35.76 10.04 551 177465 480004 109931279
Breast cancer 35.67 10.04 9 178007 38533 110372750
Onychomycosis 35.66 10.04 9 178007 38522 110372761
Human ehrlichiosis 35.43 10.04 19 177997 696 110410587
Sputum increased 35.42 10.04 45 177971 5706 110405577
Cytomegalovirus chorioretinitis 35.08 10.04 50 177966 7078 110404205
Incorrect route of product administration 34.88 10.04 31 177985 64030 110347253
Adrenal insufficiency 34.84 10.04 148 177868 42242 110369041
Liver abscess 34.77 10.04 52 177964 7687 110403596
Feeling abnormal 34.70 10.04 161 177855 180550 110230733
Oesophagitis 34.25 10.04 113 177903 28602 110382681
Basal cell carcinoma 34.17 10.04 15 178001 45255 110366028
Shock haemorrhagic 34.10 10.04 109 177907 27138 110384145
Accidental exposure to product 34.08 10.04 19 177997 49989 110361294
Nail disorder 34.06 10.04 26 177990 57909 110353374
Atelectasis 34 10.04 133 177883 36579 110374704
Therapeutic product effect incomplete 33.82 10.04 216 177800 223589 110187694
Haemodynamic instability 33.75 10.04 97 177919 22791 110388492
Hypoalbuminaemia 33.65 10.04 113 177903 28861 110382422
Diffuse large B-cell lymphoma 33.42 10.04 77 177939 15821 110395462
Skin lesion 33.37 10.04 168 177848 51463 110359820
Thrombotic microangiopathy 33.25 10.04 113 177903 29036 110382247
Ileus paralytic 32.98 10.04 64 177952 11673 110399610
Fungal skin infection 32.98 10.04 49 177967 7200 110404083
Wound infection fungal 32.94 10.04 13 178003 230 110411053
Hepatocellular injury 32.88 10.04 165 177851 50477 110360806
Diastolic dysfunction 32.88 10.04 66 177950 12338 110398945
Paraesthesia oral 32.84 10.04 124 177892 33547 110377736
Mucosal disorder 32.80 10.04 38 177978 4379 110406904
Pregnancy 32.56 10.04 21 177995 51046 110360237
Gastrooesophageal reflux disease 32.44 10.04 164 177852 179812 110231471
Suicidal ideation 32.21 10.04 64 177952 93873 110317410
Laryngitis 32.10 10.04 14 178002 42397 110368886
Muscle spasticity 32.08 10.04 9 178007 35906 110375377
Flushing 32.06 10.04 76 177940 104660 110306623
Osteomyelitis fungal 32 10.04 15 178001 410 110410873
Venoocclusive disease 31.92 10.04 45 177971 6305 110404978
Nosocomial infection 31.61 10.04 32 177984 3167 110408116
Clostridium test positive 31.35 10.04 60 177956 10833 110400450
Lung infiltration 31.26 10.04 99 177917 24529 110386754
Neutropenic infection 31.23 10.04 32 177984 3213 110408070
Chest pain 30.98 10.04 423 177593 375952 110035331
Shock 30.94 10.04 169 177847 53419 110357864
Inhibitory drug interaction 30.93 10.04 39 177977 4908 110406375
Jarisch-Herxheimer reaction 30.77 10.04 21 177995 1196 110410087
Symmetrical drug-related intertriginous and flexural exanthema 30.62 10.04 25 177991 1872 110409411
Overgrowth fungal 30.49 10.04 11 178005 150 110411133
Rhinovirus infection 30.39 10.04 62 177954 11727 110399556
Osteonecrosis of jaw 30.27 10.04 20 177996 47997 110363286
Upper respiratory tract infection 30.21 10.04 334 177682 130994 110280289
Pulmonary mucormycosis 29.97 10.04 26 177990 2117 110409166
Mycobacterium fortuitum infection 29.68 10.04 15 178001 485 110410798
Incorrect dose administered 29.55 10.04 78 177938 103563 110307720
Enterobacter test positive 29.49 10.04 15 178001 492 110410791
Cholecystitis chronic 29.43 10.04 54 177962 9446 110401837
Anxiety 29.42 10.04 385 177631 344693 110066590
Differentiation syndrome 29.26 10.04 30 177986 3014 110408269
Increased viscosity of upper respiratory secretion 29.10 10.04 16 178000 616 110410667
Stenotrophomonas test positive 29.07 10.04 14 178002 407 110410876
Blood pressure systolic increased 28.92 10.04 56 177960 82935 110328348
Confusional state 28.86 10.04 556 177460 468124 109943159
Amnesia 28.80 10.04 81 177935 105327 110305956
Pseudomonal sepsis 28.76 10.04 52 177964 8994 110402289
Penile haemorrhage 28.66 10.04 18 177998 890 110410393
Muscular weakness 28.47 10.04 259 177757 248209 110163074
Oral disorder 28.46 10.04 61 177955 11942 110399341
Metabolic acidosis 28.37 10.04 265 177751 99479 110311804
Klebsiella sepsis 27.99 10.04 34 177982 4119 110407164
Neck pain 27.81 10.04 103 177913 123027 110288256
Escherichia infection 27.76 10.04 93 177923 23723 110387560
Periostitis 27.71 10.04 17 177999 806 110410477
Fat necrosis 27.70 10.04 18 177998 944 110410339
Engraft failure 27.65 10.04 17 177999 809 110410474
Nightmare 27.61 10.04 14 178002 38849 110372434
Graft versus host disease in lung 27.55 10.04 20 177996 1258 110410025
Drug dependence 27.48 10.04 24 177992 49996 110361287
Epilepsy 27.39 10.04 77 177939 100132 110311151
Adenovirus infection 27.37 10.04 57 177959 10937 110400346
Blood immunoglobulin M increased 27.32 10.04 22 177994 1615 110409668
Intentional self-injury 27.32 10.04 13 178003 37416 110373867
Platelet transfusion 27.27 10.04 28 177988 2818 110408465
Fungal oesophagitis 27.23 10.04 19 177997 1122 110410161
Blood corticosterone increased 27.17 10.04 5 178011 0 110411283
Mycobacterium avium complex infection 27.13 10.04 40 177976 5837 110405446
Aortoenteric fistula 26.91 10.04 10 178006 149 110411134
Fungal peritonitis 26.90 10.04 20 177996 1305 110409978
Decreased immune responsiveness 26.53 10.04 52 177964 9554 110401729
Candida test positive 26.50 10.04 20 177996 1335 110409948
Pulmonary infarction 26.39 10.04 33 177983 4118 110407165
Drug tolerance decreased 26.34 10.04 6 178010 27534 110383749
Abscess neck 26.33 10.04 20 177996 1348 110409935
Liver transplant rejection 26.28 10.04 32 177984 3886 110407397
Hypertensive crisis 26.10 10.04 4 178012 24368 110386915
Prostate cancer 26.09 10.04 14 178002 37627 110373656
Abscess 25.83 10.04 100 177916 27369 110383914
Hyperferritinaemia 25.77 10.04 18 177998 1065 110410218
Neutrophilic dermatosis 25.75 10.04 16 178000 776 110410507
Post procedural bile leak 25.65 10.04 13 178003 423 110410860
Philadelphia positive acute lymphocytic leukaemia 25.46 10.04 8 178008 69 110411214
Arteritis infective 25.39 10.04 10 178006 176 110411107
Chronic lymphocytic leukaemia 25.25 10.04 39 177977 5929 110405354
Disease recurrence 25.19 10.04 176 177840 60608 110350675
SARS-CoV-2 sepsis 25.18 10.04 11 178005 254 110411029
Encephalitis fungal 25.14 10.04 11 178005 255 110411028
Full blood count abnormal 25.07 10.04 32 177984 56020 110355263
Acquired macroglossia 25.06 10.04 11 178005 257 110411026
Therapeutic response decreased 25.02 10.04 76 177940 96423 110314860
Acquired immunodeficiency syndrome 25.01 10.04 12 178004 346 110410937
Liver function test increased 24.97 10.04 67 177949 88481 110322802
Mediastinal effusion 24.97 10.04 8 178008 74 110411209
Hepatosplenomegaly 24.89 10.04 42 177974 6877 110404406
Growth failure 24.78 10.04 11 178005 264 110411019
Nasal abscess 24.63 10.04 10 178006 191 110411092
Trichoglossia 24.21 10.04 16 178000 864 110410419
Allergic keratitis 24.07 10.04 6 178010 19 110411264
Tonsillar haemorrhage 23.94 10.04 11 178005 287 110410996
Ventricular tachycardia 23.87 10.04 150 177866 49859 110361424
BK virus infection 23.81 10.04 60 177956 13046 110398237
Infection reactivation 23.67 10.04 31 177985 4050 110407233
Extravasation blood 23.66 10.04 13 178003 500 110410783
Sepsis syndrome 23.61 10.04 20 177996 1576 110409707
Myelosuppression 23.59 10.04 244 177772 94096 110317187
Maternal exposure timing unspecified 23.56 10.04 3 178013 21010 110390273
Electrocardiogram J wave abnormal 23.39 10.04 6 178010 22 110411261
Blood immunoglobulin A decreased 23.16 10.04 23 177993 2225 110409058
Oral fungal infection 23.05 10.04 32 177984 4420 110406863
Focal myositis 22.98 10.04 6 178010 24 110411259
Nail infection 22.98 10.04 24 177992 2464 110408819
Oral pain 22.92 10.04 120 177896 37324 110373959
Gastritis fungal 22.87 10.04 11 178005 319 110410964
Mycobacterial peritonitis 22.80 10.04 10 178006 233 110411050
CD4 lymphocytes decreased 22.78 10.04 26 177990 2948 110408335
Meningitis 22.77 10.04 55 177961 11647 110399636
Acute graft versus host disease in intestine 22.68 10.04 36 177980 5603 110405680
Enterovirus infection 22.56 10.04 25 177991 2745 110408538
Fungal endocarditis 22.51 10.04 15 178001 821 110410462
Retinitis 22.44 10.04 12 178004 32315 110378968
Chronic hepatitis C 22.38 10.04 14 178002 687 110410596
Clostridial infection 22.33 10.04 38 177978 6264 110405019
Chronic obstructive pulmonary disease 22.31 10.04 95 177921 109063 110302220
Visual impairment 22.27 10.04 126 177890 134302 110276981
Pseudomonas test positive 22.27 10.04 23 177993 2331 110408952
Pneumonia klebsiella 22.21 10.04 39 177977 6593 110404690
Injection site bruising 22.17 10.04 30 177986 51233 110360050
Cardiac failure congestive 22.17 10.04 147 177869 150853 110260430
Somnolence 22.12 10.04 341 177675 297108 110114175
Brain oedema 22.11 10.04 104 177912 30994 110380289
Dystonia 22.08 10.04 7 178009 25798 110385485
Joint neoplasm 22.02 10.04 7 178009 63 110411220
Respiratory moniliasis 21.97 10.04 12 178004 456 110410827
Hypoxia 21.89 10.04 311 177705 129204 110282079
Dry eye 21.84 10.04 35 177981 55758 110355525
Prescribed underdose 21.83 10.04 45 177971 65129 110346154
Candida pneumonia 21.75 10.04 16 178000 1027 110410256
Dermatitis exfoliative 21.73 10.04 53 177963 11294 110399989
Pneumonitis 21.60 10.04 203 177813 76328 110334955
Immune reconstitution inflammatory syndrome associated tuberculosis 21.60 10.04 16 178000 1038 110410245
Heart rate decreased 21.58 10.04 65 177951 82691 110328592
Neuropathy peripheral 21.56 10.04 407 177609 178870 110232413
Musculoskeletal disorder 21.55 10.04 5 178011 22659 110388624
Sinusitis 21.43 10.04 342 177674 296346 110114937
Hysterectomy 21.30 10.04 43 177973 8071 110403212
Hospitalisation 21.28 10.04 138 177878 142355 110268928
Influenza like illness 21.27 10.04 72 177944 88340 110322943
Cough 21.23 10.04 573 177443 461068 109950215
Respiratory distress 21.12 10.04 186 177830 68688 110342595
Walking aid user 21.10 10.04 7 178009 25068 110386215
Epidermolysis bullosa 21.10 10.04 11 178005 380 110410903
Pain in jaw 21.09 10.04 31 177985 51146 110360137
Renal graft infection 21.03 10.04 14 178002 765 110410518
Pneumonia pseudomonal 21.03 10.04 41 177975 7505 110403778
Blood beta-D-glucan increased 20.97 10.04 14 178002 769 110410514
Disseminated tuberculosis 20.90 10.04 33 177983 5113 110406170
Encephalitis viral 20.89 10.04 25 177991 2982 110408301
Urinary tract infection fungal 20.76 10.04 17 177999 1278 110410005
Fracture 20.72 10.04 7 178009 24781 110386502
Tongue coated 20.65 10.04 20 177996 1876 110409407
Hepatosplenic candidiasis 20.51 10.04 13 178003 653 110410630
Injection site mass 20.49 10.04 7 178009 24606 110386677
Sinus polyp 20.42 10.04 13 178003 658 110410625
Petechiae 20.41 10.04 83 177933 23234 110388049
Rhinocerebral mucormycosis 20.40 10.04 18 177998 1499 110409784
Neutropenic colitis 20.30 10.04 42 177974 8023 110403260
Product prescribing error 20.28 10.04 32 177984 51299 110359984
Diabetic macroangiopathy 20.14 10.04 8 178008 144 110411139
Epidermolysis 20.02 10.04 16 178000 1162 110410121
Streptococcal infection 19.94 10.04 50 177966 10840 110400443
Poisoning 19.91 10.04 11 178005 29094 110382189
Generalised oedema 19.90 10.04 100 177916 30604 110380679
Vomiting 19.90 10.04 1232 176784 909443 109501840
Cognitive disorder 19.89 10.04 73 177943 87438 110323845
Joint injury 19.86 10.04 21 177995 39973 110371310
Portal fibrosis 19.84 10.04 13 178003 692 110410591
Ultrasound foetal abnormal 19.78 10.04 7 178009 90 110411193
Oral mucosa erosion 19.78 10.04 22 177994 2426 110408857
Injury 19.77 10.04 186 177830 177079 110234204
Drug-induced liver injury 19.77 10.04 287 177729 119780 110291503
Procedural pain 19.75 10.04 111 177905 35454 110375829
Exposure via breast milk 19.72 10.04 15 178001 1013 110410270
Sedation complication 19.65 10.04 4 178012 19851 110391432
Ear infection 19.62 10.04 45 177971 62687 110348596
Restlessness 19.57 10.04 38 177978 56221 110355062
Mediastinitis 19.52 10.04 17 177999 1391 110409892
Serratia infection 19.46 10.04 21 177995 2238 110409045
Injection site pruritus 19.28 10.04 33 177983 51225 110360058
Acquired apparent mineralocorticoid excess 19.24 10.04 7 178009 98 110411185
Bradycardia 19.19 10.04 159 177857 155358 110255925
Virologic failure 19.08 10.04 31 177985 4921 110406362
HIV associated nephropathy 19.01 10.04 10 178006 352 110410931
Soft tissue neoplasm 18.92 10.04 7 178009 103 110411180
Dementia 18.89 10.04 14 178002 31659 110379624
Throat irritation 18.78 10.04 36 177980 53516 110357767
Disease progression 18.71 10.04 520 177496 243514 110167769
Irritability 18.70 10.04 30 177986 47779 110363504
Choreoathetosis 18.66 10.04 18 177998 1680 110409603
Emphysema 18.64 10.04 72 177944 19684 110391599
Cerebrovascular accident 18.64 10.04 194 177822 181090 110230193
Drug eruption 18.63 10.04 149 177867 53510 110357773
Raoultella ornithinolytica infection 18.62 10.04 8 178008 177 110411106
Infection in an immunocompromised host 18.54 10.04 19 177997 1908 110409375
Endocarditis candida 18.50 10.04 7 178009 110 110411173
Peripheral sensory neuropathy 18.45 10.04 64 177952 16616 110394667
Angina pectoris 18.44 10.04 46 177970 62249 110349034
Injection site warmth 18.32 10.04 3 178013 17402 110393881
Bladder cancer 18.28 10.04 5 178011 20287 110390996
Resorption bone increased 18.27 10.04 17 177999 1517 110409766
Angioimmunoblastic T-cell lymphoma 18.26 10.04 12 178004 642 110410641
Varicella zoster virus infection 18.23 10.04 35 177981 6333 110404950
Macule 18.20 10.04 26 177990 3687 110407596
Antithrombin III decreased 18.17 10.04 11 178005 509 110410774
Gingivitis ulcerative 18.17 10.04 11 178005 509 110410774
Stiff person syndrome 18.16 10.04 12 178004 648 110410635
Urinary tract inflammation 18.12 10.04 10 178006 388 110410895
Renal abscess 18.06 10.04 17 177999 1539 110409744
Injection site urticaria 18.04 10.04 3 178013 17212 110394071
Prothrombin time prolonged 18.03 10.04 65 177951 17196 110394087
Nasal congestion 18.02 10.04 89 177927 98193 110313090
Scedosporium infection 18.01 10.04 21 177995 2437 110408846
Infectious pleural effusion 18.01 10.04 30 177986 4861 110406422
Skin oedema 17.96 10.04 19 177997 1980 110409303
Splenic vein thrombosis 17.95 10.04 14 178002 981 110410302
Haemorrhage 17.95 10.04 256 177760 106436 110304847
Band neutrophil count decreased 17.89 10.04 7 178009 121 110411162
Endotracheal intubation 17.88 10.04 34 177982 6110 110405173
Blood test abnormal 17.85 10.04 12 178004 28542 110382741
Ulcer haemorrhage 17.81 10.04 7 178009 22564 110388719
Hepatomegaly 17.78 10.04 75 177941 21339 110389944
Adverse reaction 17.76 10.04 13 178003 29581 110381702
Pneumonia influenzal 17.72 10.04 26 177990 3779 110407504
Mental status changes 17.69 10.04 194 177822 75928 110335355
Linear IgA disease 17.62 10.04 28 177988 4361 110406922
H1N1 influenza 17.62 10.04 23 177993 2995 110408288
Arthritis fungal 17.61 10.04 8 178008 203 110411080
Conductive deafness 17.59 10.04 9 178007 299 110410984
Limb discomfort 17.58 10.04 24 177992 40830 110370453
Bacillus infection 17.53 10.04 17 177999 1597 110409686
Hepatitis fulminant 17.49 10.04 41 177975 8519 110402764
Vaginal mucosal blistering 17.49 10.04 5 178011 30 110411253
Cerebral aspergillosis 17.42 10.04 20 177996 2282 110409001
Fluid retention 17.38 10.04 230 177786 94077 110317206
Cardiac murmur 17.30 10.04 9 178007 24619 110386664
Metastases to bone 17.29 10.04 15 178001 31357 110379926
Fibrin degradation products increased 17.25 10.04 10 178006 427 110410856
Wound dehiscence 17.22 10.04 39 177977 7923 110403360
Gastrointestinal necrosis 17.21 10.04 35 177981 6605 110404678
Vulvovaginal mycotic infection 17.21 10.04 31 177985 5346 110405937
Blood albumin decreased 17.18 10.04 89 177927 27563 110383720
Hot flush 17.13 10.04 52 177964 65984 110345299
Hypophagia 17.12 10.04 144 177872 52482 110358801
Skin hyperpigmentation 17.06 10.04 41 177975 8655 110402628
Mycotic endophthalmitis 17.06 10.04 10 178006 436 110410847
Acanthosis 17.03 10.04 11 178005 571 110410712
Device malfunction 17.00 10.04 10 178006 25548 110385735
Abdominal distension 16.95 10.04 190 177826 174913 110236370
Puerperal pyrexia 16.95 10.04 5 178011 34 110411249
Lymphocyte adoptive therapy 16.95 10.04 7 178009 140 110411143
Anaphylactic shock 16.92 10.04 36 177980 51510 110359773
Kidney transplant rejection 16.91 10.04 50 177966 11937 110399346
Peritonitis bacterial 16.87 10.04 46 177970 10487 110400796
Haematotoxicity 16.86 10.04 73 177943 21009 110390274
Balance disorder 16.84 10.04 114 177902 116446 110294837
T-cell lymphoma recurrent 16.82 10.04 6 178010 79 110411204
Klebsiella bacteraemia 16.78 10.04 29 177987 4840 110406443
Dysarthria 16.71 10.04 74 177942 84047 110327236
Hepatic necrosis 16.56 10.04 44 177972 9878 110401405
Lung neoplasm malignant 16.55 10.04 18 177998 33824 110377459
Pulmonary cavitation 16.50 10.04 19 177997 2175 110409108
Acute myocardial infarction 16.46 10.04 74 177942 83703 110327580
Leukaemic infiltration extramedullary 16.46 10.04 9 178007 343 110410940
Condition aggravated 16.41 10.04 992 177024 733844 109677439
Primary adrenal insufficiency 16.33 10.04 11 178005 613 110410670
Serum ferritin increased 16.31 10.04 49 177967 11798 110399485
Vulvovaginal disorder 16.30 10.04 3 178013 0 110411283
Blood immunoglobulin G increased 16.27 10.04 25 177991 3783 110407500
Dermatitis 16.21 10.04 88 177928 27749 110383534
Haemoglobin decreased 16.10 10.04 519 177497 248208 110163075
Cardiovascular insufficiency 16.08 10.04 23 177993 3265 110408018
Herpes simplex test positive 16.08 10.04 11 178005 629 110410654
Affect lability 16.04 10.04 5 178011 18632 110392651
Citrobacter infection 16.04 10.04 15 178001 1347 110409936
Epstein-Barr viraemia 16.01 10.04 24 177992 3555 110407728
Disability 16.00 10.04 15 178001 30208 110381075
Ulcer 15.99 10.04 28 177988 43088 110368195
Erythroblast count increased 15.97 10.04 4 178012 13 110411270
Vulvovaginitis 15.97 10.04 9 178007 364 110410919
Lymphadenopathy 15.91 10.04 165 177851 63670 110347613
Blood sodium decreased 15.91 10.04 111 177905 38208 110373075
Death 15.85 10.04 942 177074 697927 109713356
Necrotising retinitis 15.83 10.04 16 178000 1580 110409703
Staphylococcus test positive 15.83 10.04 36 177980 7334 110403949
Fibrin D dimer increased 15.77 10.04 43 177973 9802 110401481
Cushingoid 15.71 10.04 48 177968 11664 110399619
Blood fibrinogen increased 15.71 10.04 18 177998 2050 110409233
Graft thrombosis 15.68 10.04 10 178006 508 110410775
Injection site haemorrhage 15.67 10.04 18 177998 33010 110378273
Proteus infection 15.66 10.04 21 177995 2807 110408476
Post transplant lymphoproliferative disorder 15.64 10.04 58 177958 15555 110395728
Acute lymphocytic leukaemia recurrent 15.59 10.04 31 177985 5756 110405527
Culture stool positive 15.51 10.04 11 178005 667 110410616
Mucosal infection 15.50 10.04 10 178006 518 110410765
Pancreatitis necrotising 15.46 10.04 30 177986 5471 110405812
Leukaemia recurrent 15.46 10.04 22 177994 3109 110408174
Coagulation factor V level decreased 15.43 10.04 11 178005 672 110410611
Xerosis 15.40 10.04 16 178000 1633 110409650
Central nervous system vasculitis 15.36 10.04 16 178000 1638 110409645
Hypercalcaemia 15.36 10.04 128 177888 46529 110364754
Enterococcus test positive 15.23 10.04 21 177995 2883 110408400
Transfusion 15.15 10.04 81 177935 25391 110385892
Middle insomnia 15.15 10.04 7 178009 20495 110390788
Funguria 15.13 10.04 4 178012 17 110411266
Superinfection bacterial 15.12 10.04 19 177997 2382 110408901
Genital haemorrhage 15.11 10.04 35 177981 7217 110404066
Drug tolerance 15.11 10.04 4 178012 16581 110394702
Procalcitonin increased 15.10 10.04 25 177991 4031 110407252
Peritonitis 15.06 10.04 97 177919 32510 110378773
Movement disorder 15.05 10.04 22 177994 36382 110374901
Metastases to liver 15.01 10.04 21 177995 35365 110375918
Withdrawal syndrome 15.00 10.04 17 177999 31363 110379920
Cytomegalovirus test 15.00 10.04 5 178011 53 110411230
Diverticulum 14.99 10.04 57 177959 15469 110395814
Tongue blistering 14.95 10.04 17 177999 1920 110409363
Failure to thrive 14.94 10.04 52 177964 13522 110397761
Gastrointestinal viral infection 14.92 10.04 16 178000 1693 110409590
Paraspinal abscess 14.86 10.04 9 178007 417 110410866
Klebsiella test positive 14.84 10.04 19 177997 2427 110408856
Cytomegalovirus gastroenteritis 14.83 10.04 11 178005 715 110410568
Delusion 14.83 10.04 10 178006 23745 110387538
Hepatic enzyme increased 14.82 10.04 398 177618 320494 110090789
Infective keratitis 14.81 10.04 6 178010 114 110411169
Psychotic disorder 14.78 10.04 38 177978 50899 110360384
Urogenital infection fungal 14.75 10.04 5 178011 56 110411227
Hypoglossal nerve paresis 14.71 10.04 6 178010 116 110411167
Splenomegaly 14.64 10.04 78 177938 24420 110386863
Ocular icterus 14.62 10.04 31 177985 6022 110405261
Peritoneal candidiasis 14.60 10.04 4 178012 20 110411263
Pulmonary embolism 14.53 10.04 450 177566 214024 110197259
Idiosyncratic drug reaction 14.52 10.04 15 178001 1521 110409762
Cushing's syndrome 14.47 10.04 12 178004 918 110410365
Prothrombin time shortened 14.28 10.04 23 177993 3623 110407660
Gallstone ileus 14.28 10.04 4 178012 22 110411261
Red blood cell schistocytes present 14.24 10.04 11 178005 760 110410523
Anticonvulsant drug level abnormal 14.22 10.04 5 178011 63 110411220
Drug level above therapeutic 14.18 10.04 46 177970 11542 110399741
Neuropsychiatric syndrome 14.15 10.04 7 178009 216 110411067
Herpes simplex oesophagitis 14.15 10.04 9 178007 455 110410828
Fluorosis 14.09 10.04 7 178009 218 110411065
Viral haemorrhagic cystitis 14.09 10.04 22 177994 3377 110407906
Chest discomfort 14.07 10.04 196 177820 173652 110237631
Acute respiratory failure 14.06 10.04 184 177832 75076 110336207
Transaminases increased 14.02 10.04 160 177856 63230 110348053
Metastases to lung 14.01 10.04 10 178006 23053 110388230
Product substitution issue 14.01 10.04 10 178006 23051 110388232
Posterior reversible encephalopathy syndrome 14.00 10.04 98 177918 33763 110377520
Phalangeal hypoplasia 13.99 10.04 4 178012 24 110411259
Anal candidiasis 13.99 10.04 4 178012 24 110411259
Plasma cell leukaemia 13.92 10.04 17 177999 2071 110409212
CD4/CD8 ratio decreased 13.87 10.04 5 178011 68 110411215
Acid base balance abnormal 13.85 10.04 9 178007 472 110410811
Infective corneal ulcer 13.72 10.04 4 178012 26 110411257
Gallbladder fistula 13.72 10.04 4 178012 26 110411257
PRIDE syndrome 13.72 10.04 4 178012 26 110411257
Chorioretinitis 13.70 10.04 14 178002 1401 110409882
Hypertransaminasaemia 13.67 10.04 76 177940 24179 110387104
Clostridium difficile infection 13.59 10.04 136 177880 51993 110359290
Leukoencephalopathy 13.59 10.04 39 177977 9156 110402127
Bone marrow transplant 13.55 10.04 15 178001 1645 110409638
Vertigo 13.55 10.04 83 177933 86787 110324496
Renal tubular disorder 13.49 10.04 34 177982 7395 110403888
Haemolytic anaemia 13.47 10.04 68 177948 20852 110390431
Infective chondritis 13.46 10.04 4 178012 28 110411255
Tachypnoea 13.46 10.04 109 177907 39286 110371997
No adverse event 13.46 10.04 67 177949 73772 110337511
Leukocytosis 13.35 10.04 139 177877 53689 110357594
Refractory anaemia with an excess of blasts 13.33 10.04 11 178005 836 110410447
Central nervous system lesion 13.33 10.04 55 177961 15498 110395785
Malassezia infection 13.30 10.04 5 178011 77 110411206
Adrenal suppression 13.29 10.04 15 178001 1681 110409602
Gingival ulceration 13.27 10.04 13 178003 1237 110410046
Bronchiectasis 13.26 10.04 24 177992 36469 110374814
Application site haematoma 13.25 10.04 5 178011 78 110411205
Neonatal respiratory distress 13.22 10.04 4 178012 30 110411253
Organ failure 13.21 10.04 26 177990 4791 110406492
Mechanical ventilation 13.15 10.04 21 177995 3286 110407997
Herpes virus infection 13.12 10.04 37 177979 8601 110402682
Pleocytosis 13.09 10.04 15 178001 1709 110409574
Hyperglycaemia 13.07 10.04 201 177815 84889 110326394
Livedo reticularis 13.07 10.04 28 177988 5478 110405805
Liver function test abnormal 13.06 10.04 169 177847 68781 110342502
Escherichia bacteraemia 13.03 10.04 41 177975 10123 110401160
WT1 gene mutation 13.01 10.04 3 178013 6 110411277
Rash morbilliform 13.01 10.04 35 177981 7916 110403367
Immunosuppressant drug level decreased 13.00 10.04 19 177997 2752 110408531
Impaired work ability 12.97 10.04 14 178002 26405 110384878
Hypofibrinogenaemia 12.95 10.04 18 177998 2489 110408794
Hypogonadism 12.91 10.04 16 178000 1978 110409305
Chronic myeloid leukaemia recurrent 12.86 10.04 8 178008 389 110410894
Pneumothorax 12.81 10.04 99 177917 35186 110376097
Periorbital cellulitis 12.81 10.04 12 178004 1080 110410203
Congenital foot malformation 12.78 10.04 4 178012 34 110411249
Cerebral fungal infection 12.77 10.04 10 178006 705 110410578
Tarsal tunnel syndrome 12.77 10.04 9 178007 540 110410743
Acute febrile neutrophilic dermatosis 12.77 10.04 26 177990 4910 110406373
Spinal cord injury thoracic 12.77 10.04 6 178010 165 110411118
Parenteral nutrition 12.75 10.04 11 178005 889 110410394
Multiple sclerosis relapse 12.72 10.04 40 177976 50200 110361083
Oral mucosal erythema 12.71 10.04 17 177999 2267 110409016
Palpitations 12.70 10.04 180 177836 159032 110252251
Urinary tract infection enterococcal 12.69 10.04 22 177994 3680 110407603
Perineal pain 12.68 10.04 14 178002 1531 110409752
HIV-associated neurocognitive disorder 12.66 10.04 8 178008 400 110410883
Aplasia pure red cell 12.61 10.04 39 177977 9539 110401744
Hyperleukocytosis 12.54 10.04 21 177995 3418 110407865
Pseudomonal bacteraemia 12.49 10.04 24 177992 4347 110406936
Pharyngeal stenosis 12.48 10.04 4 178012 37 110411246
Right ventricular failure 12.47 10.04 14 178002 25940 110385343
Adenovirus reactivation 12.47 10.04 10 178006 730 110410553
Renal tubular acidosis 12.39 10.04 25 177991 4690 110406593
Scopulariopsis infection 12.38 10.04 6 178010 177 110411106
Extrapyramidal disorder 12.38 10.04 17 177999 28850 110382433
Thrombotic thrombocytopenic purpura 12.35 10.04 32 177984 7079 110404204
Iatrogenic infection 12.34 10.04 5 178011 95 110411188
Presyncope 12.32 10.04 39 177977 48848 110362435
Abdominal sepsis 12.30 10.04 17 177999 2338 110408945
Pulmonary nocardiosis 12.29 10.04 18 177998 2611 110408672
Lymphatic disorder 12.25 10.04 8 178008 423 110410860
Respiratory syncytial virus infection 12.24 10.04 51 177965 14433 110396850
Product administration error 12.21 10.04 26 177990 37191 110374092
Leukaemia 12.21 10.04 33 177983 7485 110403798
Central nervous system leukaemia 12.18 10.04 9 178007 582 110410701
Gallbladder fibrosis 12.16 10.04 3 178013 9 110411274
Drug withdrawal syndrome 12.14 10.04 27 177989 38027 110373256
Hypersensitivity 12.14 10.04 529 177487 403469 110007814
Supraventricular tachycardia 12.12 10.04 74 177942 24348 110386935
Drug use disorder 12.12 10.04 7 178009 18067 110393216
Vulvovaginal discomfort 12.11 10.04 16 178000 2108 110409175
Epistaxis 12.10 10.04 285 177731 130087 110281196
Epstein-Barr virus associated lymphoproliferative disorder 12.08 10.04 25 177991 4777 110406506
Cardiac arrest 12.07 10.04 408 177608 196345 110214938
Panniculitis 12.02 10.04 5 178011 15577 110395706
Hyperadrenocorticism 12.01 10.04 9 178007 594 110410689
Cerebral infarction 11.99 10.04 132 177884 51706 110359577
Skin fissures 11.97 10.04 13 178003 24445 110386838
Cryptococcal cutaneous infection 11.97 10.04 7 178009 304 110410979
Bacterial infection 11.95 10.04 120 177896 45916 110365367
BK polyomavirus test positive 11.95 10.04 7 178009 305 110410978
Secondary syphilis 11.92 10.04 5 178011 104 110411179
Exposure to toxic agent 11.90 10.04 3 178013 12855 110398428
Cytomegalovirus oesophagitis 11.88 10.04 11 178005 975 110410308
Vulvovaginal swelling 11.88 10.04 9 178007 604 110410679
Prostatic abscess 11.88 10.04 9 178007 604 110410679
Electrolyte imbalance 11.88 10.04 101 177915 36927 110374356
Rheumatic disorder 11.87 10.04 21 177995 3570 110407713
Purpura senile 11.86 10.04 9 178007 606 110410677
Influenza 11.85 10.04 196 177820 168905 110242378
Pseudomonas aeruginosa meningitis 11.84 10.04 5 178011 106 110411177
Bone marrow disorder 11.83 10.04 23 177993 4200 110407083
Hyperthyroidism 11.79 10.04 18 177998 29243 110382040
Acanthamoeba infection 11.75 10.04 9 178007 614 110410669
Alkalosis 11.72 10.04 10 178006 796 110410487
Chronic myeloid leukaemia transformation 11.72 10.04 7 178009 316 110410967
Meningitis coccidioides 11.70 10.04 4 178012 46 110411237
Vulvovaginal pruritus 11.69 10.04 20 177996 3311 110407972
Pseudoaldosteronism 11.66 10.04 7 178009 319 110410964
Infection 11.61 10.04 703 177313 361497 110049786
Faeces pale 11.58 10.04 20 177996 3337 110407946
Acute encephalitis with refractory, repetitive partial seizures 11.55 10.04 4 178012 48 110411235
Oedema genital 11.51 10.04 9 178007 633 110410650
Candida endophthalmitis 11.49 10.04 6 178010 208 110411075
Eating disorder 11.48 10.04 20 177996 30838 110380445
Respiratory tract congestion 11.48 10.04 20 177996 30837 110380446
Hiatus hernia 11.48 10.04 80 177936 27526 110383757
Genital ulceration 11.45 10.04 15 178001 1960 110409323
Cheilitis 11.42 10.04 29 177987 6336 110404947
Rectal perforation 11.41 10.04 11 178005 1026 110410257
Pneumocystis jirovecii pneumonia 11.39 10.04 112 177904 42623 110368660
Hepatitis acute 11.39 10.04 60 177956 18706 110392577
Anosmia 11.37 10.04 3 178013 12469 110398814
Cholangitis infective 11.37 10.04 10 178006 829 110410454
Angina bullosa haemorrhagica 11.36 10.04 6 178010 213 110411070
Oropharyngeal plaque 11.34 10.04 8 178008 481 110410802
Interstitial lung disease 11.30 10.04 157 177859 139177 110272106
Poikiloderma 11.29 10.04 8 178008 484 110410799
Genital herpes 11.28 10.04 17 177999 2530 110408753
Splenic infarction 11.27 10.04 23 177993 4351 110406932
Gallbladder disorder 11.26 10.04 65 177951 20964 110390319
Small intestinal perforation 11.26 10.04 23 177993 4353 110406930
Oedema mucosal 11.25 10.04 16 178000 2260 110409023
Cytomegalovirus enterocolitis 11.22 10.04 16 178000 2265 110409018
Respiratory tract haemorrhage 11.22 10.04 15 178001 1999 110409284
Autoimmune haemolytic anaemia 11.22 10.04 40 177976 10527 110400756
Emotional distress 11.21 10.04 116 177900 44731 110366552
Congestive cardiomyopathy 11.19 10.04 49 177967 14170 110397113
Herpes simplex viraemia 11.19 10.04 9 178007 660 110410623
Vertebral lateral recess stenosis 11.17 10.04 7 178009 345 110410938
Cystic fibrosis related diabetes 11.16 10.04 6 178010 221 110411062
Female reproductive tract disorder 11.15 10.04 8 178008 494 110410789
Retroviral infection 11.12 10.04 3 178013 14 110411269
Pancreatic carcinoma 11.11 10.04 5 178011 14867 110396416
Persistent genital arousal disorder 11.10 10.04 9 178007 667 110410616
Carpal tunnel syndrome 11.08 10.04 12 178004 22598 110388685
Heparin-induced thrombocytopenia 11.08 10.04 42 177974 11382 110399901
Anaphylactic reaction 11.07 10.04 124 177892 114176 110297107
Malignant neoplasm progression 11.06 10.04 206 177810 174361 110236922
Herpes dermatitis 11.02 10.04 7 178009 353 110410930
Escherichia sepsis 11.00 10.04 39 177977 10233 110401050
Renal ischaemia 11.00 10.04 16 178000 2307 110408976
Heart rate increased 10.99 10.04 164 177852 143670 110267613
Immune system disorder 10.99 10.04 47 177969 13454 110397829
Coronary artery disease 10.92 10.04 69 177947 71621 110339662
Bacterial diarrhoea 10.84 10.04 7 178009 363 110410920
Graft loss 10.84 10.04 12 178004 1316 110409967
Thrombophlebitis 10.80 10.04 32 177984 7647 110403636
Xanthopsia 10.76 10.04 7 178009 368 110410915
Ligamentum flavum hypertrophy 10.76 10.04 7 178009 368 110410915
Heliotrope rash 10.75 10.04 6 178010 238 110411045
Poor peripheral circulation 10.73 10.04 22 177994 4175 110407108
Histoplasmosis 10.72 10.04 18 177998 2935 110408348
Hypogammaglobulinaemia 10.72 10.04 62 177954 20014 110391269
Hypoxic-ischaemic encephalopathy 10.72 10.04 35 177981 8812 110402471
Dyspepsia 10.70 10.04 230 177786 190735 110220548
Pancreatitis acute 10.69 10.04 146 177870 60128 110351155
Osteoarthropathy 10.69 10.04 7 178009 372 110410911
Herpes simplex 10.69 10.04 52 177964 15712 110395571
Osteopenia 10.65 10.04 12 178004 22197 110389086
Unevaluable event 10.65 10.04 54 177962 59173 110352110
Hiccups 10.63 10.04 45 177971 12824 110398459
Dehydration 10.62 10.04 551 177465 278960 110132323
Transient ischaemic attack 10.58 10.04 60 177956 63922 110347361
Lymphoma 10.58 10.04 62 177954 20109 110391174
Blastomycosis 10.58 10.04 11 178005 1124 110410159
Staphylococcal scalded skin syndrome 10.56 10.04 8 178008 537 110410746
Allergy test positive 10.55 10.04 10 178006 913 110410370
Fungal pharyngitis 10.55 10.04 6 178010 247 110411036
Forced expiratory volume decreased 10.54 10.04 4 178012 13172 110398111
Delayed graft function 10.52 10.04 22 177994 4235 110407048
SJS-TEN overlap 10.51 10.04 14 178002 1860 110409423
High-grade B-cell lymphoma 10.50 10.04 6 178010 249 110411034
Biliary dyskinesia 10.50 10.04 16 178000 2405 110408878
Clostridium colitis 10.47 10.04 19 177997 3296 110407987
Proctitis bacterial 10.46 10.04 5 178011 143 110411140
Respiratory paralysis 10.46 10.04 5 178011 143 110411140
Myocarditis toxoplasmal 10.45 10.04 4 178012 65 110411218
Sputum abnormal 10.42 10.04 12 178004 1374 110409909
Pulmonary hilum mass 10.41 10.04 7 178009 389 110410894
Blood chloride increased 10.38 10.04 28 177988 6344 110404939
Sputum purulent 10.37 10.04 14 178002 1884 110409399
Oxygen saturation decreased 10.34 10.04 184 177832 156798 110254485
Cardiac disorder 10.34 10.04 76 177940 76204 110335079
Genital pain 10.32 10.04 12 178004 1388 110409895
Ischaemic hepatitis 10.31 10.04 23 177993 4625 110406658
Infusion site reaction 10.31 10.04 8 178008 17674 110393609
Ankle fracture 10.30 10.04 10 178006 19809 110391474
Graft versus host disease in liver 10.28 10.04 16 178000 2449 110408834
Disturbance in sexual arousal 10.25 10.04 7 178009 399 110410884
Streptococcal bacteraemia 10.24 10.04 23 177993 4646 110406637
Stoma site candida 10.22 10.04 3 178013 20 110411263
Myalgia 10.22 10.04 276 177740 222105 110189178
Disseminated aspergillosis 10.21 10.04 16 178000 2464 110408819
Oral mucosal blistering 10.17 10.04 32 177984 7902 110403381
Vascular device infection 10.16 10.04 53 177963 16459 110394824
Product storage error 10.14 10.04 12 178004 21716 110389567
Oesophageal carcinoma 10.09 10.04 3 178013 11521 110399762
Aggression 10.08 10.04 55 177961 59155 110352128
Urinary tract candidiasis 10.07 10.04 11 178005 1188 110410095
Duodenal stenosis 10.07 10.04 10 178006 967 110410316
Adult T-cell lymphoma/leukaemia 10.07 10.04 7 178009 411 110410872
Accidental overdose 10.05 10.04 46 177970 51788 110359495

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 60.14 29.26 43 278 1590 112042

Pharmacologic Action:

SourceCodeDescription
ATC D01AC15 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC J01RA07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J02AC01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
Triazole and tetrazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006727 Hormone Antagonists
MeSH PA D058888 14-alpha Demethylase Inhibitors
MeSH PA D065088 Steroid Synthesis Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065688 Cytochrome P-450 CYP2C9 Inhibitors
MeSH PA D065689 Cytochrome P-450 CYP2C19 Inhibitors
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:50183 P450 inhibitor
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:70868 antileishmanial agent
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

D01AC Imidazole and triazole derivatives 20 drugs
bifonazolechlormidazoleclotrimazoleeberconazoleeconazoleefinaconazolefenticonazoleflutrimazoleisoconazoleketoconazolelanoconazoleluliconazole show all 20 →
J01RA Combinations of antibacterials 18 drugs
amikacinazithromycincefepimecefiximecefuroximeciprofloxacinlevofloxacinmetronidazolenitazoxanidenorfloxacinnystatinofloxacin show all 18 →
J02AC Triazole and tetrazole derivatives 5 drugs
isavuconazoniumitraconazoleoteseconazoleposaconazolevoriconazole

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cryptococcal meningitis indication 14232007
Candidiasis of the esophagus indication 20639004 DOID:13146
Mucocutaneous candidiasis indication 29147005
Disseminated candidiasis indication 70572005
Candidal vulvovaginitis indication 72605008 DOID:2272
Candidiasis of mouth indication 79740000 DOID:14262
Candidal septicemia indication 187022007
Candidemia indication 432261003
Prevention of Disseminated Candidiasis indication
Candidal Urinary Tract Infection indication
Oropharyngeal Candidiasis indication
Tinea capitis off-label use 5441008
Tinea pedis off-label use 6020002 DOID:12403
Histoplasmosis off-label use 12962009 DOID:1731
Tinea manus off-label use 48971001 DOID:13369
Pityriasis versicolor off-label use 56454009 DOID:9060
Blastomycosis off-label use 69996000 DOID:12663
Tinea corporis off-label use 84849002
Disseminated coccidioidomycosis off-label use 85055004
Cutaneous leishmaniasis off-label use 240637006 DOID:9111
Tinea cruris off-label use 399029005
Onychomycosis due to dermatophyte off-label use 402134005
Pulmonary coccidioidomycosis off-label use 417018008
Onychomycosis due to Candida off-label use
Prevention of Vulvovaginal Candidiasis off-label use
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.55 acidic
pKa2 1.84 Basic
pKa3 1.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 4.54 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.09 CHEMBL
Lanosterol 14-alpha demethylase Enzyme Kd 4.40 CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.10 CHEMBL
Lanosterol 14-alpha demethylase Enzyme INHIBITOR IC50 6.70 WOMBAT-PK CHEMBL
Lanosterol 14-alpha demethylase Enzyme Kd 6.70 CHEMBL
14-alpha sterol demethylase Cyp51A Enzyme Kd 4.92 CHEMBL
14-alpha sterol demethylase Enzyme Kd 5.39 CHEMBL
Mycocyclosin synthase Enzyme Kd 5.22 CHEMBL
Sterol 14-alpha demethylase Enzyme IC50 6.06 CHEMBL

External reference:

IDSource
4019493 VUID
N0000147613 NUI
D00322 KEGG_DRUG
4019493 VANDF
C0016277 UMLSCUI
CHEBI:46081 CHEBI
TPF PDB_CHEM_ID
CHEMBL106 ChEMBL_ID
DB00196 DRUGBANK_ID
D015725 MESH_DESCRIPTOR_UI
3365 PUBCHEM_CID
5851 INN_ID
8VZV102JFY UNII
202813 RXNORM
3884 MMSL
4732 MMSL
59176 MMSL
d00071 MMSL
003534 NDDF
31865003 SNOMEDCT_US
387174006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 26 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 26 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9666 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9667 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9668 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9669 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9899 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0338-6045 INJECTION, SOLUTION 400 mg INTRAVENOUS ANDA 26 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0338-6046 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 26 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0409-3435 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 26 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0409-4321 INJECTION, SOLUTION 400 mg INTRAVENOUS ANDA 26 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6500 TABLET 100 mg ORAL ANDA 25 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6500 TABLET 100 mg ORAL ANDA 25 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6501 TABLET 200 mg ORAL ANDA 25 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6501 TABLET 200 mg ORAL ANDA 25 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 10544-178 TABLET 200 mg ORAL ANDA 15 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 10544-610 TABLET 200 mg ORAL ANDA 24 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 10544-855 TABLET 150 mg ORAL ANDA 22 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 12634-780 TABLET 150 mg ORAL ANDA 23 sections
FLUCONAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 16590-282 TABLET 150 mg ORAL ANDA 24 sections