fluconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 1187 86386-73-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluconazole
  • difluconazole
  • flunazol
  • diflucan
Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
  • Molecular weight: 306.28
  • Formula: C13H12F2N6O
  • CLOGP: 0.10
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 81.65
  • ALOGS: -2.34
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 6 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.75 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.31 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.89 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 29, 1990 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 610.85 9.91 812 93063 117637 63277510
Drug interaction 382.84 9.91 962 92913 228169 63166978
Candida infection 370.72 9.91 319 93556 28032 63367115
Mucosal inflammation 266.94 9.91 338 93537 46590 63348557
Pemphigus 235.83 9.91 8 93867 183718 63211429
Sepsis 215.84 9.91 604 93271 152519 63242628
Hand deformity 208.03 9.91 6 93869 159451 63235696
Thrombocytopenia 207.91 9.91 591 93284 150566 63244581
Glossodynia 206.77 9.91 15 93860 178861 63216286
Fungal infection 205.60 9.91 263 93612 36611 63358536
Cytokine release syndrome 205.47 9.91 170 93705 14144 63381003
Systemic lupus erythematosus 204.76 9.91 32 93843 208886 63186261
Multiple organ dysfunction syndrome 202.01 9.91 327 93548 56425 63338722
Synovitis 199.05 9.91 22 93853 186896 63208251
Stevens-Johnson syndrome 190.53 9.91 209 93666 24741 63370406
Pancytopenia 185.09 9.91 429 93446 96504 63298643
Oral candidiasis 167.23 9.91 187 93688 22611 63372536
Arthropathy 160.73 9.91 73 93802 234719 63160428
Abdominal discomfort 159.34 9.91 144 93731 320741 63074406
Arthralgia 158.63 9.91 383 93492 569327 62825820
Contraindicated product administered 158.07 9.91 62 93813 217586 63177561
Joint swelling 158.05 9.91 151 93724 327515 63067632
Therapeutic product effect decreased 155.95 9.91 46 93829 193141 63202006
Septic shock 153.41 9.91 318 93557 66311 63328836
Neutropenia 146.63 9.91 579 93296 174426 63220721
Platelet count decreased 141.45 9.91 435 93440 115687 63279460
Cytomegalovirus infection 140.39 9.91 164 93711 20788 63374359
Wound 139.04 9.91 35 93840 163228 63231919
Pyrexia 138.85 9.91 1177 92698 469301 62925846
Female genital tract fistula 136.97 9.91 103 93772 7456 63387691
Alopecia 131.01 9.91 185 93690 337351 63057796
Graft versus host disease 128.91 9.91 95 93780 6668 63388479
Maternal exposure during pregnancy 123.93 9.91 87 93788 219975 63175172
Pathogen resistance 117.76 9.91 88 93787 6310 63388837
Rheumatoid arthritis 116.55 9.91 122 93753 253697 63141450
Aspergillus infection 115.90 9.91 96 93779 7997 63387150
Pericarditis 114.38 9.91 27 93848 131552 63263595
Swelling 113.87 9.91 144 93731 275234 63119913
Neutrophil count decreased 111.31 9.91 253 93622 56153 63338994
Vaginal discharge 109.18 9.91 98 93777 9100 63386047
Mucormycosis 108.51 9.91 62 93813 2809 63392338
Toxic epidermal necrolysis 108.40 9.91 159 93716 25175 63369972
Drug intolerance 107.47 9.91 182 93693 308479 63086668
Discomfort 101.24 9.91 61 93814 167313 63227834
Helicobacter infection 101.09 9.91 10 93865 92775 63302372
Drug resistance 96.77 9.91 143 93732 22790 63372357
Sinusitis fungal 95.62 9.91 49 93826 1782 63393365
Deep vein thrombosis 94.73 9.91 306 93569 83494 63311653
Musculoskeletal stiffness 91.35 9.91 83 93792 184535 63210612
Abortion spontaneous 90.15 9.91 209 93666 46986 63348161
Systemic candida 88.88 9.91 57 93818 3188 63391959
Enterococcal infection 86.08 9.91 80 93795 7768 63387379
Salpingo-oophorectomy unilateral 84.80 9.91 36 93839 845 63394302
Bronchopulmonary aspergillosis 83.30 9.91 82 93793 8553 63386594
Immune reconstitution inflammatory syndrome 82.64 9.91 70 93805 6014 63389133
Fixed eruption 78.24 9.91 37 93838 1127 63394020
Infusion related reaction 76.35 9.91 155 93720 245366 63149781
Peripheral swelling 75.99 9.91 176 93699 265766 63129381
Fall 75.61 9.91 311 93564 392023 63003124
Oesophageal candidiasis 74.56 9.91 64 93811 5599 63389548
Nasopharyngitis 72.86 9.91 168 93707 254089 63141058
Fungaemia 72.81 9.91 45 93830 2358 63392789
Fatigue 72.13 9.91 905 92970 887123 62508024
Mouth ulceration 71.90 9.91 154 93721 32830 63362317
Sputum increased 71.86 9.91 45 93830 2414 63392733
Irritable bowel syndrome 71.43 9.91 17 93858 82395 63312752
Cytomegalovirus viraemia 70.65 9.91 62 93813 5587 63389560
Acute myeloid leukaemia 69.60 9.91 105 93770 17042 63378105
Vaginal flatulence 69.02 9.91 49 93826 3244 63391903
Skin candida 68.68 9.91 38 93837 1617 63393530
Impaired healing 66.86 9.91 34 93841 102508 63292639
Proctitis 66.62 9.91 59 93816 5382 63389765
Plasma cell myeloma 66.38 9.91 157 93718 35748 63359399
Intentional overdose 62.89 9.91 16 93859 74136 63321011
Hepatic enzyme increased 62.65 9.91 128 93747 202200 63192947
Laryngitis fungal 61.72 9.91 18 93857 129 63395018
Embolism venous 61.68 9.91 45 93830 3109 63392038
Respiratory symptom 61.51 9.91 46 93829 3301 63391846
Disseminated mucormycosis 61.35 9.91 19 93856 171 63394976
Infective aneurysm 61.29 9.91 23 93852 386 63394761
Aplastic anaemia 60.95 9.91 73 93802 9496 63385651
Torsade de pointes 60.33 9.91 86 93789 13265 63381882
White blood cell count decreased 59.72 9.91 381 93494 138723 63256424
Drug ineffective 59.59 9.91 1139 92736 1043626 62351521
Neutropenic sepsis 58.83 9.91 95 93780 16343 63378804
Anaemia 58.40 9.91 677 93198 292753 63102394
Folliculitis 58.07 9.91 16 93859 70301 63324846
Acute graft versus host disease in skin 58.06 9.91 45 93830 3407 63391740
Respiratory failure 57.46 9.91 300 93575 101558 63293589
Bacterial sepsis 56.78 9.91 47 93828 3911 63391236
Colitis 55.54 9.91 178 93697 48350 63346797
Immune effector cell-associated neurotoxicity syndrome 55.06 9.91 37 93838 2240 63392907
Treatment failure 55.01 9.91 134 93741 198909 63196238
Pneumonia fungal 54.86 9.91 53 93822 5402 63389745
Bone marrow failure 54.06 9.91 128 93747 29162 63365985
Renal failure 53.47 9.91 327 93548 117325 63277822
Pseudomonas infection 53.29 9.91 74 93801 11139 63384008
Hypersensitivity 53.26 9.91 237 93638 292448 63102699
Foetal death 52.99 9.91 73 93802 10907 63384240
Dermatitis bullous 52.71 9.91 64 93811 8444 63386703
Vulvovaginal candidiasis 52.56 9.91 41 93834 3134 63392013
Pain 51.66 9.91 778 93097 739850 62655297
Blood lactate dehydrogenase increased 51.62 9.91 109 93766 23007 63372140
Bacteraemia 51.18 9.91 92 93783 17256 63377891
Suicide attempt 50.04 9.91 14 93861 60904 63334243
Pulmonary embolism 49.71 9.91 319 93556 116365 63278782
Fungal sepsis 49.54 9.91 28 93847 1242 63393905
Hypomagnesaemia 49.20 9.91 122 93753 28615 63366532
Uterine perforation 49.15 9.91 56 93819 6907 63388240
Chronic sinusitis 48.41 9.91 76 93799 12767 63382380
Cytomegalovirus test positive 47.86 9.91 38 93837 2980 63392167
Blood alkaline phosphatase increased 46.82 9.91 155 93720 42812 63352335
Fibromyalgia 46.28 9.91 31 93844 80389 63314758
Drug level increased 45.97 9.91 103 93772 22633 63372514
Agranulocytosis 45.48 9.91 109 93766 25025 63370122
Cystitis haemorrhagic 45.16 9.91 42 93833 4081 63391066
Acute generalised exanthematous pustulosis 45.09 9.91 68 93807 11031 63384116
Blood bilirubin increased 45.04 9.91 139 93736 37001 63358146
Psoriatic arthropathy 44.23 9.91 42 93833 91478 63303669
International normalised ratio increased 44.09 9.91 160 93715 46265 63348882
Dysphagia 43.96 9.91 252 93623 88333 63306814
Diastolic dysfunction 43.92 9.91 51 93824 6420 63388727
Intentional product use issue 43.89 9.91 76 93799 127816 63267331
Injection site pain 43.76 9.91 78 93797 129722 63265425
Neurotoxicity 43.75 9.91 85 93790 16905 63378242
Therapeutic product effect incomplete 43.21 9.91 74 93801 124982 63270165
Radiculopathy 42.69 9.91 58 93817 8553 63386594
Aspartate aminotransferase increased 42.33 9.91 253 93622 90024 63305123
Knee arthroplasty 41.75 9.91 14 93861 54192 63340955
Hepatic function abnormal 41.38 9.91 135 93740 37007 63358140
Cryptococcosis 41.10 9.91 24 93851 1133 63394014
Mobility decreased 40.67 9.91 73 93802 121086 63274061
Acute kidney injury 40.64 9.91 580 93295 262835 63132312
Staphylococcal infection 39.87 9.91 143 93732 41113 63354034
Cutaneous coccidioidomycosis 39.80 9.91 9 93866 18 63395129
Tumour lysis syndrome 39.29 9.91 57 93818 8933 63386214
BK virus infection 39.04 9.91 35 93840 3244 63391903
Drug ineffective for unapproved indication 39.02 9.91 125 93750 33938 63361209
Acute graft versus host disease 38.95 9.91 40 93835 4388 63390759
Ill-defined disorder 38.95 9.91 38 93837 81717 63313430
Device related infection 38.67 9.91 98 93777 23294 63371853
Jarisch-Herxheimer reaction 38.27 9.91 16 93859 361 63394786
Geotrichum infection 37.91 9.91 17 93858 457 63394690
Adverse event 37.60 9.91 27 93848 67532 63327615
Rash erythematous 37.44 9.91 143 93732 42367 63352780
Cholecystitis chronic 37.24 9.91 60 93815 10301 63384846
Klebsiella infection 36.98 9.91 54 93821 8512 63386635
Contusion 36.90 9.91 107 93768 149937 63245210
Alanine aminotransferase increased 36.67 9.91 271 93604 103499 63291648
Tonsillar haemorrhage 36.66 9.91 14 93861 247 63394900
Epstein-Barr virus infection 36.58 9.91 52 93823 7998 63387149
Gastrointestinal fungal infection 36.02 9.91 15 93860 335 63394812
Immunosuppressant drug level increased 35.93 9.91 35 93840 3603 63391544
Hypokalaemia 35.50 9.91 269 93606 103535 63291612
Enterobacter infection 35.23 9.91 28 93847 2199 63392948
Drug reaction with eosinophilia and systemic symptoms 35.04 9.91 120 93755 33716 63361431
Vaginal infection 34.81 9.91 49 93826 7469 63387678
Oral disorder 34.21 9.91 53 93822 8801 63386346
Blood cholesterol increased 34.00 9.91 54 93821 93978 63301169
Rash maculo-papular 33.80 9.91 114 93761 31782 63363365
Gamma-glutamyltransferase increased 33.77 9.91 119 93756 33912 63361235
Nasal polyps 33.53 9.91 43 93832 5996 63389151
Haemophagocytic lymphohistiocytosis 33.47 9.91 58 93817 10569 63384578
Loss of personal independence in daily activities 33.21 9.91 58 93817 97232 63297915
Constipation 32.98 9.91 491 93384 224452 63170695
Injection site erythema 32.77 9.91 45 93830 83129 63312018
Electrocardiogram QT prolonged 32.64 9.91 174 93701 59356 63335791
Dizziness 32.54 9.91 444 93431 429481 62965666
Product use issue 32.48 9.91 192 93683 220328 63174819
Shock haemorrhagic 32.47 9.91 55 93820 9840 63385307
Type 2 diabetes mellitus 32.42 9.91 28 93847 63840 63331307
Hepatic failure 32.27 9.91 121 93754 35535 63359612
Acute myeloid leukaemia recurrent 31.39 9.91 23 93852 1600 63393547
Neuropathy peripheral 31.05 9.91 280 93595 113387 63281760
Cholestasis 31.02 9.91 105 93770 29329 63365818
Congenital absence of cranial vault 30.96 9.91 7 93868 14 63395133
Condition aggravated 30.93 9.91 414 93461 401803 62993344
Clostridium difficile colitis 30.76 9.91 83 93792 20486 63374661
Hip arthroplasty 30.75 9.91 16 93859 47630 63347517
Disseminated intravascular coagulation 30.65 9.91 79 93796 18972 63376175
Inappropriate schedule of product administration 30.30 9.91 68 93807 103897 63291250
Breast cancer 30.13 9.91 17 93858 48366 63346781
Dysbiosis 30.11 9.91 18 93857 888 63394259
Erythema multiforme 30.09 9.91 54 93821 10115 63385032
Meningitis cryptococcal 30.04 9.91 21 93854 1356 63393791
Toxic neuropathy 29.99 9.91 14 93861 414 63394733
Hyperbilirubinaemia 29.62 9.91 57 93818 11257 63383890
Tricuspid valve incompetence 29.29 9.91 66 93809 14555 63380592
Nasal abscess 29.13 9.91 11 93864 188 63394959
Chronic graft versus host disease 29.07 9.91 29 93846 3073 63392074
Toxoplasmosis 28.14 9.91 21 93854 1502 63393645
Leukopenia 27.96 9.91 203 93672 77087 63318060
Fungal oesophagitis 27.94 9.91 16 93859 728 63394419
Injection site swelling 27.82 9.91 18 93857 47554 63347593
Symmetrical drug-related intertriginous and flexural exanthema 27.81 9.91 14 93861 490 63394657
Drug abuse 27.81 9.91 40 93835 72478 63322669
Staphylococcal sepsis 27.77 9.91 46 93829 8082 63387065
Engraftment syndrome 27.71 9.91 14 93861 494 63394653
Sinus polyp 27.61 9.91 13 93862 392 63394755
Oral fungal infection 27.33 9.91 28 93847 3063 63392084
Enterococcal sepsis 27.21 9.91 20 93855 1398 63393749
Pneumonia 27.18 9.91 875 93000 455892 62939255
Gastrointestinal disorder 27.14 9.91 101 93774 131138 63264009
Abscess neck 26.69 9.91 15 93860 658 63394489
Blood immunoglobulin M increased 26.27 9.91 18 93857 1125 63394022
Hypertension 26.26 9.91 275 93600 279028 63116119
Blood immunoglobulin A decreased 26.23 9.91 19 93856 1298 63393849
Renal tubular acidosis 26.18 9.91 21 93854 1671 63393476
Puerperal pyrexia 26.14 9.91 7 93868 35 63395112
Emphysema 26.09 9.91 53 93822 10885 63384262
Soft tissue neoplasm 25.93 9.91 8 93867 71 63395076
Basal cell carcinoma 25.83 9.91 5 93870 27986 63367161
Swollen tongue 25.81 9.91 111 93764 34689 63360458
Sleep disorder 25.74 9.91 51 93824 81515 63313632
Eosinophilia 25.60 9.91 83 93792 22673 63372474
Arthritis 25.45 9.91 87 93788 115834 63279313
Candida sepsis 25.44 9.91 19 93856 1361 63393786
Respiratory tract infection fungal 25.41 9.91 13 93862 471 63394676
Wrong technique in product usage process 25.30 9.91 33 93842 62307 63332840
Congestive cardiomyopathy 25.29 9.91 38 93837 6144 63389003
Septic embolus 25.17 9.91 16 93859 881 63394266
Accidental exposure to product 25.07 9.91 5 93870 27400 63367747
Encephalitis fungal 24.93 9.91 7 93868 43 63395104
Stenotrophomonas infection 24.85 9.91 22 93853 2005 63393142
Enterococcal bacteraemia 24.50 9.91 19 93856 1440 63393707
Sepsis syndrome 24.45 9.91 16 93859 926 63394221
Toxicity to various agents 24.24 9.91 241 93634 247009 63148138
Staphylococcal bacteraemia 24.07 9.91 35 93840 5495 63389652
Blood pressure increased 23.90 9.91 141 93734 161921 63233226
Diverticulum 23.88 9.91 54 93821 11937 63383210
Blood pressure systolic increased 23.79 9.91 21 93854 47376 63347771
Neutropenic colitis 23.75 9.91 26 93849 3069 63392078
Liver abscess 23.70 9.91 25 93850 2829 63392318
C-reactive protein abnormal 23.65 9.91 20 93855 46076 63349071
Pleural effusion 23.64 9.91 226 93649 92984 63302163
Fungal endocarditis 23.62 9.91 10 93865 233 63394914
Failure to thrive 23.61 9.91 40 93835 7158 63387989
Adrenal insufficiency 23.56 9.91 69 93806 17846 63377301
Acute graft versus host disease in intestine 23.50 9.91 20 93855 1729 63393418
Focal myositis 23.49 9.91 6 93869 24 63395123
Blast cell count increased 23.48 9.91 12 93863 434 63394713
Pain in extremity 23.41 9.91 347 93528 331139 63064008
Systemic mycosis 23.23 9.91 17 93858 1180 63393967
Venoocclusive liver disease 23.11 9.91 32 93843 4803 63390344
Cytopenia 22.83 9.91 52 93823 11549 63383598
Stem cell transplant 22.79 9.91 20 93855 1802 63393345
Antithrombin III decreased 22.79 9.91 10 93865 255 63394892
Live birth 22.78 9.91 5 93870 25625 63369522
Myelosuppression 22.76 9.91 82 93793 23621 63371526
Temperature regulation disorder 22.71 9.91 36 93839 6096 63389051
Encephalopathy 22.63 9.91 115 93760 38505 63356642
Joint neoplasm 22.60 9.91 7 93868 63 63395084
Nail infection 22.57 9.91 23 93852 2500 63392647
Therapeutic response decreased 22.56 9.91 35 93840 61490 63333657
Nervous system disorder 22.53 9.91 70 93805 18696 63376451
Odynophagia 22.46 9.91 40 93835 7446 63387701
Toxic skin eruption 22.37 9.91 55 93820 12830 63382317
Resorption bone increased 22.28 9.91 17 93858 1257 63393890
Malaise 22.14 9.91 458 93417 415496 62979651
Transplant rejection 21.97 9.91 49 93826 10731 63384416
Diabetic macroangiopathy 21.84 9.91 8 93867 125 63395022
Plasma cell leukaemia 21.82 9.91 16 93859 1114 63394033
Coccidioidomycosis 21.73 9.91 15 93860 949 63394198
Drug eruption 21.65 9.91 92 93783 28602 63366545
Fat necrosis 21.64 9.91 13 93862 647 63394500
Feeling abnormal 21.41 9.91 130 93745 148262 63246885
Oral pain 21.39 9.91 91 93784 28303 63366844
Poor peripheral circulation 21.29 9.91 27 93848 3722 63391425
Weight increased 21.29 9.91 265 93610 260527 63134620
Incorrect dose administered 21.15 9.91 35 93840 59933 63335214
Tongue coated 21.14 9.91 17 93858 1358 63393789
Acinetobacter infection 21.06 9.91 18 93857 1565 63393582
Urinary tract infection fungal 21.02 9.91 13 93862 682 63394465
Oesophagitis 20.89 9.91 59 93816 14949 63380198
Disseminated cryptococcosis 20.88 9.91 11 93864 424 63394723
Long QT syndrome 20.86 9.91 25 93850 3254 63391893
Acute lymphocytic leukaemia 20.82 9.91 22 93853 2494 63392653
Injury 20.80 9.91 182 93693 73065 63322082
Viral haemorrhagic cystitis 20.72 9.91 14 93861 855 63394292
Gastrointestinal mucormycosis 20.67 9.91 9 93866 225 63394922
Cystic fibrosis related diabetes 20.57 9.91 6 93869 43 63395104
Disease recurrence 20.48 9.91 89 93786 27941 63367206
Thrombotic microangiopathy 20.41 9.91 47 93828 10514 63384633
Overgrowth fungal 20.36 9.91 7 93868 90 63395057
Candida test positive 20.34 9.91 14 93861 882 63394265
Hysterectomy 20.29 9.91 44 93831 9455 63385692
Anhedonia 20.29 9.91 48 93827 10926 63384221
Lung infiltration 20.27 9.91 57 93818 14406 63380741
Delayed graft function 20.04 9.91 15 93860 1078 63394069
Graft versus host disease in skin 19.89 9.91 23 93852 2882 63392265
Medication error 19.89 9.91 29 93846 52255 63342892
Emotional distress 19.83 9.91 98 93777 32451 63362696
Engraft failure 19.71 9.91 10 93865 356 63394791
Livedo reticularis 19.66 9.91 21 93854 2411 63392736
Herpes simplex 19.64 9.91 40 93835 8231 63386916
Renal abscess 19.49 9.91 13 93862 777 63394370
Adverse drug reaction 19.48 9.91 57 93818 79657 63315490
Leukocytosis 19.45 9.91 83 93792 25852 63369295
Status epilepticus 19.39 9.91 58 93817 15175 63379972
Philadelphia positive acute lymphocytic leukaemia 19.38 9.91 5 93870 21 63395126
Gastritis fungal 19.37 9.91 7 93868 105 63395042
Prothrombin time shortened 19.34 9.91 19 93856 1976 63393171
Blood pressure fluctuation 19.33 9.91 24 93851 46293 63348854
Leukoencephalopathy 19.31 9.91 28 93847 4385 63390762
Hiatus hernia 19.31 9.91 73 93802 21521 63373626
Graft versus host disease in lung 19.30 9.91 10 93865 372 63394775
Post transplant lymphoproliferative disorder 19.28 9.91 30 93845 5001 63390146
Pulmonary infarction 19.23 9.91 22 93853 2725 63392422
Mediastinal effusion 19.18 9.91 6 93869 56 63395091
Generalised oedema 18.99 9.91 59 93816 15759 63379388
Tongue blistering 18.94 9.91 17 93858 1578 63393569
Escherichia infection 18.60 9.91 51 93824 12703 63382444
Respiratory moniliasis 18.60 9.91 8 93867 194 63394953
Pulmonary haemorrhage 18.58 9.91 36 93839 7145 63388002
Renal impairment 18.49 9.91 206 93669 88149 63306998
Skin exfoliation 18.44 9.91 118 93757 42984 63352163
HIV infection 18.35 9.91 10 93865 413 63394734
Abdominal pain upper 18.29 9.91 206 93669 206238 63188909
Injection site bruising 18.25 9.91 21 93854 41889 63353258
Pseudomonal sepsis 18.13 9.91 20 93855 2381 63392766
Necrotising enterocolitis neonatal 18.12 9.91 8 93867 207 63394940
Liver injury 18.11 9.91 39 93836 60481 63334666
Food allergy 18.05 9.91 47 93828 11354 63383793
Mucosal disorder 18.01 9.91 19 93856 2150 63392997
Blastomycosis 17.90 9.91 9 93866 314 63394833
Graft versus host disease in gastrointestinal tract 17.87 9.91 23 93852 3218 63391929
Diffuse large B-cell lymphoma 17.79 9.91 34 93841 6678 63388469
Coagulation factor V level decreased 17.77 9.91 9 93866 319 63394828
Poikiloderma 17.64 9.91 8 93867 221 63394926
Aeromonas infection 17.53 9.91 6 93869 76 63395071
Shock 17.52 9.91 75 93800 23388 63371759
Growth failure 17.49 9.91 9 93866 330 63394817
Septic pulmonary embolism 17.12 9.91 6 93869 82 63395065
Hepatic artery aneurysm 17.08 9.91 4 93871 10 63395137
Pharyngeal stenosis 17.08 9.91 4 93871 10 63395137
General physical health deterioration 17.05 9.91 203 93672 201199 63193948
Cerebral toxoplasmosis 17.00 9.91 13 93862 965 63394182
Hepatitis acute 16.98 9.91 40 93835 9080 63386067
Petechiae 16.83 9.91 52 93823 13845 63381302
Ureaplasma infection 16.76 9.91 11 93864 640 63394507
Swelling face 16.64 9.91 155 93720 63320 63331827
Nightmare 16.55 9.91 4 93871 19190 63375957
Epstein-Barr virus associated lymphoproliferative disorder 16.46 9.91 17 93858 1877 63393270
Blood culture positive 16.45 9.91 27 93848 4708 63390439
Acid base balance abnormal 16.41 9.91 8 93867 261 63394886
Fibrin degradation products increased 16.38 9.91 7 93868 167 63394980
Stoma site candida 16.30 9.91 4 93871 13 63395134
Feeling hot 16.30 9.91 31 93844 50323 63344824
Blood immunoglobulin G increased 16.26 9.91 19 93856 2408 63392739
Arteritis infective 16.24 9.91 5 93870 44 63395103
Red blood cell sedimentation rate increased 16.14 9.91 25 93850 43957 63351190
Restlessness 16.09 9.91 12 93863 29441 63365706
Metabolic acidosis 16.08 9.91 118 93757 44951 63350196
Product dose omission issue 15.93 9.91 247 93628 234066 63161081
Inflammation 15.93 9.91 65 93810 82208 63312939
Angioimmunoblastic T-cell lymphoma 15.92 9.91 6 93869 102 63395045
Acquired macroglossia 15.86 9.91 7 93868 181 63394966
Night sweats 15.85 9.91 30 93845 48784 63346363
Hiccups 15.84 9.91 18 93857 2213 63392934
Lower limb fracture 15.83 9.91 8 93867 24213 63370934
Vulvovaginal mycotic infection 15.76 9.91 29 93846 5537 63389610
Mucosal erosion 15.76 9.91 15 93860 1501 63393646
Purpura senile 15.69 9.91 10 93865 553 63394594
PRIDE syndrome 15.66 9.91 4 93871 16 63395131
Infective chondritis 15.66 9.91 4 93871 16 63395131
Neural tube defect 15.38 9.91 7 93868 195 63394952
Inhibitory drug interaction 15.37 9.91 20 93855 2829 63392318
Hypoglossal nerve paresis 15.35 9.91 6 93869 113 63395034
Immunodeficiency 15.33 9.91 65 93810 20189 63374958
Refractory anaemia with an excess of blasts 15.16 9.91 9 93866 438 63394709
Oral mucosal blistering 15.15 9.91 29 93846 5704 63389443
Grip strength decreased 15.11 9.91 7 93868 22280 63372867
Respiratory tract haemorrhage 15.00 9.91 9 93866 447 63394700
Blood creatinine increased 14.97 9.91 197 93678 87647 63307500
Disseminated coccidioidomycosis 14.93 9.91 5 93870 59 63395088
Secondary amyloidosis 14.93 9.91 6 93869 122 63395025
Splenic vein thrombosis 14.84 9.91 8 93867 323 63394824
Vulvovaginal pruritus 14.81 9.91 21 93854 3222 63391925
Vulvovaginitis 14.71 9.91 8 93867 329 63394818
Dyspnoea 14.71 9.91 814 93061 660499 62734648
Varicella zoster virus infection 14.70 9.91 19 93856 2670 63392477
Bone erosion 14.68 9.91 4 93871 17713 63377434
Acute sinusitis 14.64 9.91 23 93852 3864 63391283
Leukaemia 14.62 9.91 24 93851 4184 63390963
Rhinorrhoea 14.53 9.91 49 93826 65528 63329619
Sleep apnoea syndrome 14.52 9.91 83 93792 29050 63366097
Acute respiratory distress syndrome 14.44 9.91 71 93804 23463 63371684
Injection site pruritus 14.41 9.91 28 93847 45088 63350059
Upper respiratory tract infection 14.40 9.91 185 93690 81862 63313285
Capillary leak syndrome 14.37 9.91 17 93858 2183 63392964
Systemic inflammatory response syndrome 14.32 9.91 28 93847 5593 63389554
Haemodialysis 14.29 9.91 37 93838 8910 63386237
Joint stiffness 14.25 9.91 25 93850 41844 63353303
Angina bullosa haemorrhagica 14.25 9.91 6 93869 138 63395009
Posterior reversible encephalopathy syndrome 14.18 9.91 57 93818 17288 63377859
Enterocolitis 14.13 9.91 34 93841 7824 63387323
Colitis ulcerative 14.12 9.91 76 93799 26015 63369132
Primary adrenal insufficiency 14.09 9.91 6 93869 142 63395005
Metapneumovirus pneumonia 14.05 9.91 4 93871 26 63395121
Wound infection fungal 14.05 9.91 6 93869 143 63395004
Right ventricular failure 14.02 9.91 4 93871 17184 63377963
Central nervous system lymphoma 14.00 9.91 14 93861 1488 63393659
Post procedural bile leak 13.97 9.91 6 93869 145 63395002
Cushing's syndrome 13.89 9.91 10 93865 677 63394470
Gait disturbance 13.88 9.91 189 93686 182989 63212158
Angiodermatitis 13.78 9.91 5 93870 76 63395071
Leukaemic infiltration extramedullary 13.72 9.91 5 93870 77 63395070
Lichenoid keratosis 13.72 9.91 15 93860 1768 63393379
Acinetobacter test positive 13.60 9.91 5 93870 79 63395068
Duodenal stenosis 13.57 9.91 9 93866 533 63394614
Fracture 13.52 9.91 6 93869 19578 63375569
Oropharyngeal candidiasis 13.51 9.91 12 93863 1099 63394048
Vulvovaginal swelling 13.43 9.91 9 93866 542 63394605
Intentional self-injury 13.35 9.91 11 93864 25676 63369471
Vulvovaginal discomfort 13.31 9.91 17 93858 2361 63392786
Insomnia 13.28 9.91 231 93644 215021 63180126
Road traffic accident 13.27 9.91 21 93854 36611 63358536
Fungal test positive 13.27 9.91 9 93866 553 63394594
Gingival ulceration 13.25 9.91 11 93864 919 63394228
Erythema 13.25 9.91 347 93528 175404 63219743
Staphylococcus test positive 13.24 9.91 22 93853 3874 63391273
Foot deformity 13.20 9.91 13 93862 27840 63367307
Gallbladder disorder 13.14 9.91 59 93816 18783 63376364
Tarsal tunnel syndrome 13.10 9.91 9 93866 565 63394582
Jaundice 13.08 9.91 81 93794 29170 63365977
Dehydration 12.99 9.91 342 93533 173012 63222135
Fungal skin infection 12.98 9.91 24 93851 4598 63390549
Abdominal pain 12.98 9.91 544 93331 292912 63102235
Rash morbilliform 12.98 9.91 20 93855 3305 63391842
Vulvovaginal disorder 12.95 9.91 3 93872 7 63395140
Immunosuppressant drug level decreased 12.91 9.91 11 93864 952 63394195
Herpes simplex oesophagitis 12.80 9.91 6 93869 179 63394968
Cachexia 12.78 9.91 27 93848 5699 63389448
CD4 lymphocytes decreased 12.75 9.91 13 93862 1414 63393733
Heliotrope rash 12.74 9.91 6 93869 181 63394966
Chronic hepatitis C 12.71 9.91 6 93869 182 63394965
Streptococcal sepsis 12.65 9.91 15 93860 1931 63393216
Anencephaly 12.60 9.91 7 93868 300 63394847
Joint dislocation 12.60 9.91 6 93869 18794 63376353
Lymphopenia 12.49 9.91 57 93818 18270 63376877
Pulmonary fibrosis 12.46 9.91 25 93850 39784 63355363
Encephalitis 12.45 9.91 35 93840 8845 63386302
Cushingoid 12.45 9.91 34 93841 8451 63386696
Gallbladder fibrosis 12.41 9.91 3 93872 9 63395138
Eczema 12.36 9.91 86 93789 32205 63362942
Rhinocerebral mucormycosis 12.32 9.91 8 93867 457 63394690
Respiratory syncytial virus infection 12.23 9.91 30 93845 6988 63388159
Skin maceration 12.20 9.91 4 93871 44 63395103
Haemorrhage 12.19 9.91 141 93734 60881 63334266
Skin hyperpigmentation 12.17 9.91 27 93848 5894 63389253
Xanthopsia 12.16 9.91 6 93869 201 63394946
Dermatitis diaper 12.03 9.91 6 93869 206 63394941
Herpes simplex viraemia 12.02 9.91 7 93868 329 63394818
Ileus paralytic 12.00 9.91 23 93852 4528 63390619
Exposure via breast milk 11.98 9.91 15 93860 2042 63393105
Atelectasis 11.91 9.91 63 93812 21420 63373727
Heparin-induced thrombocytopenia 11.89 9.91 23 93852 4559 63390588
Brain oedema 11.88 9.91 47 93828 14148 63380999
Meningitis 11.79 9.91 30 93845 7147 63388000
Memory impairment 11.78 9.91 98 93777 104160 63290987
Acute febrile neutrophilic dermatosis 11.77 9.91 18 93857 2956 63392191
CSF culture positive 11.74 9.91 3 93872 12 63395135
Epidermolysis 11.74 9.91 9 93866 670 63394477
Therapy non-responder 11.74 9.91 65 93810 75836 63319311
Renal tubular disorder 11.71 9.91 17 93858 2665 63392482
Myocardial infarction 11.70 9.91 93 93782 99800 63295347
Out of specification test results 11.67 9.91 5 93870 120 63395027
Subdiaphragmatic abscess 11.66 9.91 4 93871 51 63395096
Urinary tract infection enterococcal 11.56 9.91 17 93858 2696 63392451
Hepatotoxicity 11.55 9.91 94 93781 36947 63358200
Biliary dyskinesia 11.49 9.91 17 93858 2712 63392435
Hypoalbuminaemia 11.47 9.91 41 93834 11764 63383383
Pain in jaw 11.44 9.91 30 93845 43466 63351681
Extremity necrosis 11.43 9.91 13 93862 1600 63393547
Thrombophlebitis 11.42 9.91 22 93853 4346 63390801
Proteus infection 11.42 9.91 11 93864 1117 63394030
Vomiting projectile 11.40 9.91 12 93863 1354 63393793
Pneumothorax 11.40 9.91 51 93824 16210 63378937
Diabetic hyperosmolar coma 11.39 9.91 7 93868 363 63394784
Genital haemorrhage 11.38 9.91 30 93845 7302 63387845
Citrobacter test positive 11.37 9.91 3 93872 14 63395133
Joint range of motion decreased 11.37 9.91 19 93856 32409 63362738
Thrombocytosis 11.36 9.91 26 93849 5792 63389355
Clostridial infection 11.34 9.91 22 93853 4370 63390777
Myelodysplastic syndrome 11.34 9.91 52 93823 16702 63378445
Rheumatic disorder 11.33 9.91 18 93857 3054 63392093
Hypercholesterolaemia 11.26 9.91 9 93866 21325 63373822
Mucosal toxicity 11.24 9.91 7 93868 372 63394775
Transferrin decreased 11.18 9.91 6 93869 240 63394907
Gastrointestinal necrosis 11.16 9.91 17 93858 2781 63392366
Coma 11.15 9.91 53 93822 64311 63330836
Multiple-drug resistance 11.10 9.91 24 93851 5146 63390001
Impaired work ability 11.08 9.91 6 93869 17469 63377678
Product deposit 11.05 9.91 6 93869 246 63394901
Vaginal mucosal blistering 11.04 9.91 3 93872 16 63395131
Central nervous system leukaemia 11.03 9.91 5 93870 138 63395009
Enterobacter test positive 11.02 9.91 6 93869 247 63394900
SJS-TEN overlap 11.00 9.91 7 93868 386 63394761
Oliguria 10.97 9.91 34 93841 9067 63386080
Encephalitis cytomegalovirus 10.96 9.91 8 93867 553 63394594
Acute lymphocytic leukaemia recurrent 10.82 9.91 15 93860 2254 63392893
Cardiomyopathy acute 10.81 9.91 6 93869 257 63394890
Enterocolitis bacterial 10.79 9.91 6 93869 258 63394889
Adenovirus reactivation 10.77 9.91 5 93870 146 63395001
Perihepatic abscess 10.74 9.91 3 93872 18 63395129
Flushing 10.71 9.91 66 93809 75021 63320126
Cytomegalovirus oesophagitis 10.70 9.91 6 93869 262 63394885
Stress 10.68 9.91 57 93818 67110 63328037
Underdose 10.67 9.91 15 93860 27441 63367706
Palatal oedema 10.66 9.91 8 93867 577 63394570
Pathological fracture 10.65 9.91 33 93842 8801 63386346
Lymphadenopathy 10.63 9.91 95 93780 38363 63356784
Gingival blister 10.61 9.91 4 93871 68 63395079
Opsoclonus myoclonus 10.58 9.91 5 93870 152 63394995
Idiopathic intracranial hypertension 10.57 9.91 17 93858 2914 63392233
Muscle spasticity 10.53 9.91 10 93865 21784 63373363
Splenic infarction 10.52 9.91 13 93862 1746 63393401
Anal candidiasis 10.35 9.91 3 93872 21 63395126
Obstructive airways disorder 10.34 9.91 59 93816 20640 63374507
Disease progression 10.32 9.91 246 93629 122512 63272635
Mastitis fungal 10.30 9.91 4 93871 74 63395073
Nasal congestion 10.28 9.91 56 93819 65604 63329543
Lip dry 10.27 9.91 5 93870 15465 63379682
Thrombophlebitis septic 10.26 9.91 5 93870 163 63394984
Allergy test positive 10.25 9.91 8 93867 612 63394535
Injection site urticaria 10.21 9.91 4 93871 14069 63381078
Blister 10.17 9.91 133 93742 129681 63265466
Apraxia 10.16 9.91 13 93862 1808 63393339
Vulvovaginal erythema 10.11 9.91 6 93869 292 63394855
Lupus-like syndrome 10.07 9.91 5 93870 15290 63379857
Lichenification 10.06 9.91 7 93868 449 63394698
Rash macular 10.01 9.91 64 93811 23300 63371847
Malnutrition 10.00 9.91 47 93828 15251 63379896
Blood chloride decreased 9.99 9.91 24 93851 5518 63389629
Herpes virus infection 9.95 9.91 24 93851 5532 63389615
Liver function test increased 9.93 9.91 21 93854 32790 63362357
Clostridium difficile infection 9.92 9.91 77 93798 29845 63365302
Mycobacterium avium complex infection 9.92 9.91 17 93858 3071 63392076

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 493.19 10.76 962 72189 135887 34747893
Immune reconstitution inflammatory syndrome 315.82 10.76 208 72943 8551 34875229
Candida infection 285.81 10.76 261 72890 17454 34866326
Pyrexia 239.86 10.76 1346 71805 331667 34552113
Drug interaction 211.07 10.76 983 72168 224963 34658817
Pancytopenia 201.66 10.76 543 72608 94614 34789166
Mucormycosis 194.73 10.76 133 73018 5809 34877971
Cytokine release syndrome 175.96 10.76 228 72923 22649 34861131
Neutropenia 167.99 10.76 711 72440 156067 34727713
Drug abuse 158.62 10.76 13 73138 99083 34784697
Graft versus host disease 155.56 10.76 148 73003 10421 34873359
Multiple organ dysfunction syndrome 151.28 10.76 426 72725 76140 34807640
Completed suicide 148.83 10.76 16 73135 98152 34785628
Septic shock 146.18 10.76 404 72747 71430 34812350
Sepsis 145.32 10.76 711 72440 165850 34717930
Pathogen resistance 141.88 10.76 134 73017 9348 34874432
Aspergillus infection 133.69 10.76 146 73005 12108 34871672
Platelet count decreased 129.72 10.76 545 72606 119172 34764608
Toxic epidermal necrolysis 127.86 10.76 190 72961 21456 34862324
Aplastic anaemia 122.42 10.76 125 73026 9591 34874189
Neutrophil count decreased 119.77 10.76 303 72848 50801 34832979
Enterococcal infection 115.94 10.76 119 73032 9187 34874593
Mucosal inflammation 115.60 10.76 252 72899 38370 34845410
Thrombocytopenia 115.45 10.76 637 72514 155610 34728170
Systemic candida 109.46 10.76 78 73073 3648 34880132
Cytomegalovirus infection 109.01 10.76 196 72955 25939 34857841
Meningitis cryptococcal 106.38 10.76 65 73086 2339 34881441
Drug resistance 95.08 10.76 184 72967 25743 34858037
Fall 94.89 10.76 175 72976 202710 34681070
Bronchopulmonary aspergillosis 92.84 10.76 133 73018 14526 34869254
Arthralgia 90.33 10.76 135 73016 169906 34713874
Fungal infection 90.01 10.76 137 73014 15798 34867982
Disseminated intravascular coagulation 86.40 10.76 160 72991 21656 34862124
Dyspnoea 85.19 10.76 453 72698 376329 34507451
Oral candidiasis 79.83 10.76 112 73039 11998 34871782
Acute myeloid leukaemia 78.72 10.76 139 73012 18131 34865649
Hepatotoxicity 74.56 10.76 149 73002 21336 34862444
Tumour lysis syndrome 73.78 10.76 130 73021 16929 34866851
Myocardial infarction 72.51 10.76 88 73063 120997 34762783
Pseudomonas infection 72.12 10.76 108 73043 12274 34871506
White blood cell count decreased 70.96 10.76 390 72761 95055 34788725
Torsade de pointes 70.25 10.76 81 73070 7128 34876652
Blood bilirubin increased 69.68 10.76 207 72944 38089 34845691
Intentional overdose 69.10 10.76 6 73145 43668 34840112
Peripheral swelling 69.06 10.76 37 73114 76504 34807276
Joint swelling 66.89 10.76 21 73130 59869 34823911
Product dose omission issue 66.52 10.76 92 73059 119619 34764161
Fatigue 65.89 10.76 480 72671 370173 34513607
Dizziness 64.19 10.76 238 72913 218283 34665497
Pain 64.06 10.76 217 72934 204458 34679322
Cytomegalovirus viraemia 63.37 10.76 78 73073 7352 34876428
Acinetobacter infection 62.18 10.76 36 73115 1171 34882609
Respiratory failure 60.66 10.76 412 72739 108160 34775620
Cryptococcosis 60.59 10.76 46 73105 2373 34881407
Candida sepsis 60.25 10.76 36 73115 1243 34882537
Immunosuppressant drug level increased 58.95 10.76 68 73083 5987 34877793
Encephalitis 58.24 10.76 74 73077 7203 34876577
Fungaemia 58.15 10.76 46 73105 2522 34881258
Neurotoxicity 57.88 10.76 121 73030 17889 34865891
Stevens-Johnson syndrome 57.32 10.76 123 73028 18516 34865264
Acute graft versus host disease 56.65 10.76 69 73082 6434 34877346
Pneumonia 56.50 10.76 1068 72083 361559 34522221
Oesophageal candidiasis 56.18 10.76 57 73094 4339 34879441
Overdose 55.75 10.76 65 73086 90994 34792786
Electrocardiogram QT prolonged 53.60 10.76 198 72953 40754 34843026
Acute graft versus host disease in skin 53.33 10.76 60 73091 5141 34878639
Bone marrow failure 52.15 10.76 157 72994 29096 34854684
Staphylococcal infection 52.11 10.76 169 72982 32591 34851189
Bacteraemia 51.57 10.76 122 73029 19595 34864185
Rheumatoid arthritis 51.39 10.76 9 73142 38229 34845551
Alanine aminotransferase increased 50.82 10.76 316 72835 80499 34803281
Drug level increased 49.64 10.76 129 73022 21967 34861813
Inappropriate schedule of product administration 49.40 10.76 35 73116 62261 34821519
Death 49.15 10.76 565 72586 397484 34486296
Toxicity to various agents 49.04 10.76 234 72917 200128 34683652
HIV infection 48.74 10.76 32 73119 1307 34882473
Cytomegalovirus chorioretinitis 48.56 10.76 48 73103 3541 34880239
Nasopharyngitis 48.40 10.76 45 73106 69923 34813857
Intentional product misuse 47.46 10.76 18 73133 45593 34838187
Wrong technique in product usage process 47.22 10.76 9 73142 35977 34847803
Lymphocyte count decreased 46.71 10.76 128 73023 22494 34861286
Insomnia 46.41 10.76 92 73059 103815 34779965
Systemic mycosis 46.37 10.76 33 73118 1540 34882240
Clostridium difficile colitis 46.31 10.76 102 73049 15628 34868152
Prostate cancer 45.91 10.76 13 73138 39636 34844144
Plasma cell myeloma 45.12 10.76 191 72960 41846 34841934
Pain in extremity 44.58 10.76 127 73024 126386 34757394
Cardiac failure congestive 44.26 10.76 66 73085 83204 34800576
Venoocclusive liver disease 42.89 10.76 67 73084 7899 34875881
Pseudomembranous colitis 42.81 10.76 40 73111 2751 34881029
Drug reaction with eosinophilia and systemic symptoms 42.68 10.76 159 72992 32853 34850927
Gait disturbance 41.92 10.76 71 73080 85069 34798711
Anxiety 41.90 10.76 91 73060 99337 34784443
Agranulocytosis 41.66 10.76 127 73024 23694 34860086
Blood lactate dehydrogenase increased 41.55 10.76 124 73027 22866 34860914
Feeling abnormal 41.05 10.76 43 73108 63192 34820588
Aspartate aminotransferase increased 40.71 10.76 262 72889 67521 34816259
Fusarium infection 40.48 10.76 27 73124 1133 34882647
Suicidal ideation 40.28 10.76 17 73134 40371 34843409
Leukopenia 40.27 10.76 247 72904 62609 34821171
Chest pain 39.88 10.76 134 73017 126628 34757152
Cystitis haemorrhagic 39.64 10.76 54 73097 5625 34878155
Stomatitis 39.47 10.76 185 72966 42329 34841451
Human ehrlichiosis 39.32 10.76 18 73133 354 34883426
Depression 39.18 10.76 91 73060 97007 34786773
Immune effector cell-associated neurotoxicity syndrome 38.35 10.76 43 73108 3670 34880110
Haemophagocytic lymphohistiocytosis 38.05 10.76 84 73067 12889 34870891
Therapeutic product effect incomplete 38.00 10.76 30 73121 50511 34833269
Cerebrovascular accident 37.09 10.76 76 73075 84735 34799045
Drug intolerance 37.01 10.76 42 73109 59528 34824252
Acute myeloid leukaemia recurrent 37.00 10.76 33 73118 2137 34881643
Hyperhidrosis 36.46 10.76 64 73087 75628 34808152
Injection site pain 36.44 10.76 18 73133 38987 34844793
Memory impairment 36.14 10.76 23 73128 43295 34840485
Periorbital cellulitis 35.69 10.76 16 73135 299 34883481
Aplasia 35.68 10.76 46 73105 4542 34879238
Hyperbilirubinaemia 35.46 10.76 96 73055 16747 34867033
Trichosporon infection 35.46 10.76 21 73130 713 34883067
Hepatic function abnormal 35.46 10.76 185 72966 44178 34839602
Stress 35.04 10.76 10 73141 30337 34853443
Pneumonia fungal 34.51 10.76 57 73094 7043 34876737
Abdominal discomfort 34.21 10.76 45 73106 59790 34823990
Acquired immunodeficiency syndrome 33.66 10.76 18 73133 500 34883280
Fungal skin infection 33.38 10.76 34 73117 2600 34881180
Hyperferritinaemia 33.20 10.76 17 73134 431 34883349
Arthropathy 32.71 10.76 8 73143 26899 34856881
Chronic graft versus host disease 32.69 10.76 43 73108 4330 34879450
Hepatitis cholestatic 32.36 10.76 59 73092 7888 34875892
Graft versus host disease in gastrointestinal tract 31.95 10.76 39 73112 3644 34880136
Penis injury 31.56 10.76 14 73137 255 34883525
Loss of personal independence in daily activities 31.47 10.76 15 73136 33164 34850616
Phalangeal hypoplasia 31.07 10.76 10 73141 70 34883710
Klebsiella infection 30.60 10.76 60 73091 8471 34875309
Coagulopathy 30.49 10.76 101 73050 19688 34864092
Epidermolysis bullosa 30.48 10.76 11 73140 113 34883667
Hepatic failure 30.41 10.76 148 73003 34383 34849397
Encephalitis viral 30.25 10.76 23 73128 1189 34882591
Acute respiratory distress syndrome 30.23 10.76 121 73030 25848 34857932
Rhinovirus infection 30.19 10.76 41 73110 4258 34879522
Weight increased 30.17 10.76 97 73054 92936 34790844
Chest discomfort 30.17 10.76 42 73109 54488 34829292
Acute myocardial infarction 30.10 10.76 41 73110 53678 34830102
Musculoskeletal stiffness 30.00 10.76 32 73119 46648 34837132
Penile haemorrhage 29.93 10.76 18 73133 629 34883151
Blood pressure increased 29.89 10.76 90 73061 88012 34795768
Bacterial infection 29.86 10.76 91 73060 16972 34866808
Chronic obstructive pulmonary disease 29.84 10.76 35 73116 48883 34834897
Nocardiosis 29.77 10.76 39 73112 3912 34879868
Toxic neuropathy 29.67 10.76 17 73134 542 34883238
Device related infection 29.30 10.76 91 73060 17146 34866634
Cerebral toxoplasmosis 29.00 10.76 26 73125 1695 34882085
Portal fibrosis 28.70 10.76 14 73137 319 34883461
Brain abscess 28.59 10.76 34 73117 3091 34880689
Blood alkaline phosphatase increased 28.45 10.76 135 73016 31040 34852740
Intracranial pressure increased 28.20 10.76 38 73113 3917 34879863
Porphyria acute 28.15 10.76 14 73137 333 34883447
Psoriatic arthropathy 28.09 10.76 4 73147 19794 34863986
Bacterial sepsis 28.05 10.76 44 73107 5206 34878574
Liver disorder 28.04 10.76 140 73011 32857 34850923
COVID-19 27.93 10.76 77 73074 77473 34806307
Drug-induced liver injury 27.89 10.76 127 73024 28705 34855075
Stem cell transplant 27.82 10.76 28 73123 2111 34881669
Headache 27.79 10.76 277 72874 200358 34683422
Asthma 27.68 10.76 29 73122 42627 34841153
Cachexia 27.56 10.76 52 73099 7134 34876646
Coccidioidomycosis 27.12 10.76 18 73133 749 34883031
Angina pectoris 27.06 10.76 16 73135 31347 34852433
Cholestasis 27.04 10.76 120 73031 26828 34856952
Aggression 27.00 10.76 25 73126 38939 34844841
Differentiation syndrome 26.79 10.76 23 73128 1415 34882365
Clostridium test positive 26.77 10.76 34 73117 3308 34880472
Musculoskeletal pain 26.62 10.76 17 73134 31946 34851834
Aortoenteric fistula 26.39 10.76 10 73141 119 34883661
Heart rate decreased 26.28 10.76 17 73134 31728 34852052
Cough 26.27 10.76 195 72956 149945 34733835
Hypoalbuminaemia 26.24 10.76 70 73081 12104 34871676
Blood corticosterone increased 25.86 10.76 5 73146 0 34883780
Malaise 25.13 10.76 258 72893 185567 34698213
Engraftment syndrome 25.06 10.76 19 73132 978 34882802
Systemic inflammatory response syndrome 25.06 10.76 48 73103 6661 34877119
Enterococcal bacteraemia 24.98 10.76 25 73126 1872 34881908
Haemodynamic instability 24.98 10.76 59 73092 9464 34874316
CD4 lymphocytes decreased 24.89 10.76 24 73127 1717 34882063
Stiff person syndrome 24.89 10.76 9 73142 93 34883687
Long QT syndrome 24.83 10.76 30 73121 2773 34881007
Blood pressure fluctuation 24.59 10.76 11 73140 25238 34858542
Acute kidney injury 24.47 10.76 822 72329 304166 34579614
Fungal test positive 24.47 10.76 15 73136 543 34883237
Drug dependence 24.46 10.76 10 73141 24207 34859573
Toxoplasmosis 24.42 10.76 21 73130 1295 34882485
Cytomegalovirus test positive 24.22 10.76 35 73116 3851 34879929
Sedation 24.11 10.76 7 73144 20999 34862781
Cardiac disorder 24.07 10.76 33 73118 43093 34840687
Adenovirus infection 23.95 10.76 41 73110 5216 34878564
Wound dehiscence 23.90 10.76 32 73119 3279 34880501
Infection 23.85 10.76 293 72858 90622 34793158
Aspartate aminotransferase 23.84 10.76 9 73142 106 34883674
Enterococcal sepsis 23.81 10.76 23 73128 1649 34882131
Oropharyngeal candidiasis 23.57 10.76 17 73134 810 34882970
Hypertension 23.49 10.76 178 72973 136265 34747515
Osteoarthritis 23.47 10.76 7 73144 20635 34863145
Wound infection fungal 23.41 10.76 7 73144 37 34883743
Therapeutic product effect decreased 23.25 10.76 23 73128 34720 34849060
Hospitalisation 23.20 10.76 53 73098 56849 34826931
Trichoglossia 23.02 10.76 12 73139 316 34883464
Heart rate irregular 22.88 10.76 3 73148 15804 34867976
Syncope 22.80 10.76 106 73045 91345 34792435
Blood culture positive 22.71 10.76 38 73113 4745 34879035
Encephalitis fungal 22.60 10.76 10 73141 181 34883599
Kaposi's sarcoma 22.58 10.76 17 73134 866 34882914
Graft versus host disease in skin 22.52 10.76 34 73117 3891 34879889
Neuroleptic malignant syndrome 22.46 10.76 5 73146 17929 34865851
Pulmonary mucormycosis 22.10 10.76 16 73135 767 34883013
Pulmonary haemorrhage 21.96 10.76 59 73092 10245 34873535
Gallstone ileus 21.83 10.76 6 73145 22 34883758
Klebsiella sepsis 21.74 10.76 24 73127 2013 34881767
Jaundice 21.50 10.76 127 73024 31755 34852025
Acute lymphocytic leukaemia 21.44 10.76 29 73122 3000 34880780
Arthritis fungal 21.28 10.76 8 73143 93 34883687
Odynophagia 21.24 10.76 40 73111 5481 34878299
Stenotrophomonas test positive 21.23 10.76 11 73140 286 34883494
Ocular icterus 21.22 10.76 28 73123 2829 34880951
Fluorosis 20.94 10.76 7 73144 56 34883724
Rash maculo-papular 20.93 10.76 116 73035 28335 34855445
Conductive deafness 20.79 10.76 11 73140 299 34883481
Anterior displaced anus 20.69 10.76 4 73147 0 34883780
Incorrect dose administered 20.66 10.76 33 73118 40482 34843298
Staphylococcal sepsis 20.61 10.76 56 73095 9788 34873992
Cytopenia 20.55 10.76 66 73085 12657 34871123
Coronary artery disease 20.51 10.76 44 73107 48261 34835519
Psoriasis 20.38 10.76 31 73120 38781 34844999
Vision blurred 20.24 10.76 41 73110 45922 34837858
Pulmonary alveolar haemorrhage 20.20 10.76 47 73104 7465 34876315
Hepatosplenic candidiasis 20.18 10.76 10 73141 236 34883544
Gamma-glutamyltransferase increased 20.07 10.76 117 73034 29114 34854666
Adrenal suppression 20.06 10.76 14 73137 633 34883147
Pulmonary nocardiosis 19.99 10.76 16 73135 892 34882888
Muscle spasms 19.86 10.76 85 73066 74916 34808864
Fungal peritonitis 19.85 10.76 15 73136 768 34883012
Drug ineffective for unapproved indication 19.71 10.76 100 73051 23615 34860165
Sleep apnoea syndrome 19.56 10.76 9 73142 20312 34863468
Foetal exposure during pregnancy 19.46 10.76 31 73120 38070 34845710
Irritability 19.40 10.76 14 73137 24676 34859104
Product prescribing error 19.36 10.76 12 73139 22915 34860865
Mycobacterium avium complex infection 19.25 10.76 25 73126 2486 34881294
Gastrooesophageal reflux disease 19.24 10.76 31 73120 37893 34845887
C-reactive protein increased 19.10 10.76 185 72966 53913 34829867
Transplant rejection 18.99 10.76 56 73095 10255 34873525
Flushing 18.92 10.76 24 73127 32396 34851384
Acute generalised exanthematous pustulosis 18.89 10.76 43 73108 6733 34877047
Enterovirus infection 18.84 10.76 16 73135 970 34882810
Engraft failure 18.61 10.76 12 73139 475 34883305
Hypokalaemia 18.60 10.76 195 72956 58019 34825761
Respiratory tract infection fungal 18.60 10.76 14 73137 713 34883067
Atelectasis 18.59 10.76 80 73071 17647 34866133
Haematotoxicity 18.56 10.76 48 73103 8146 34875634
Swollen tongue 18.43 10.76 4 73147 14601 34869179
Intentional product use issue 18.27 10.76 64 73087 59752 34824028
Central nervous system vasculitis 18.13 10.76 12 73139 497 34883283
Elbow synostosis 18.05 10.76 5 73146 19 34883761
Road traffic accident 17.96 10.76 7 73144 17443 34866337
Pseudomonal sepsis 17.95 10.76 29 73122 3518 34880262
Mobility decreased 17.90 10.76 22 73129 30106 34853674
Central venous pressure increased 17.85 10.76 5 73146 20 34883760
Hepatic necrosis 17.82 10.76 30 73121 3764 34880016
Dysbiosis 17.81 10.76 12 73139 512 34883268
Choreoathetosis 17.78 10.76 16 73135 1048 34882732
Stenotrophomonas infection 17.75 10.76 22 73129 2088 34881692
Back pain 17.74 10.76 166 72985 121623 34762157
Mycotic endophthalmitis 17.71 10.76 7 73144 94 34883686
Bladder cancer 17.65 10.76 6 73145 16272 34867508
Hepatic enzyme increased 17.61 10.76 141 73010 38939 34844841
Adrenal insufficiency 17.60 10.76 67 73084 13980 34869800
Blast cell count increased 17.60 10.76 16 73135 1062 34882718
Blood glucose increased 17.42 10.76 76 73075 66642 34817138
Nephropathy toxic 17.42 10.76 62 73089 12526 34871254
Diabetic ketoacidosis 17.33 10.76 8 73143 18024 34865756
Bradycardia 17.30 10.76 90 73061 75328 34808452
Skin necrosis 17.28 10.76 38 73113 5815 34877965
Congenital foot malformation 17.16 10.76 11 73140 431 34883349
Synostosis 17.13 10.76 7 73144 103 34883677
Secondary adrenocortical insufficiency 16.88 10.76 18 73133 1452 34882328
Opportunistic infection 16.78 10.76 19 73132 1639 34882141
Epstein-Barr viraemia 16.74 10.76 17 73134 1295 34882485
Renal failure 16.72 10.76 374 72777 130183 34753597
IVth nerve paralysis 16.72 10.76 7 73144 110 34883670
Oral mucosal erythema 16.72 10.76 11 73140 451 34883329
Neutropenic sepsis 16.71 10.76 65 73086 13702 34870078
Eschar 16.65 10.76 13 73138 699 34883081
Prostatic specific antigen increased 16.65 10.76 5 73146 14675 34869105
Idiosyncratic drug reaction 16.42 10.76 11 73140 465 34883315
Platelet transfusion 16.32 10.76 18 73133 1508 34882272
Obstructive airways disorder 16.31 10.76 6 73145 15488 34868292
Respiratory distress 16.25 10.76 129 73022 35536 34848244
Renal impairment 16.23 10.76 283 72868 94230 34789550
Gastrointestinal mucormycosis 16.22 10.76 8 73143 187 34883593
Unevaluable event 16.19 10.76 27 73124 32563 34851217
Hyperadrenocorticism 16.06 10.76 7 73144 122 34883658
Sleep disorder 15.98 10.76 26 73125 31662 34852118
Disseminated cryptococcosis 15.96 10.76 17 73134 1369 34882411
SARS-CoV-2 sepsis 15.90 10.76 7 73144 125 34883655
Angioedema 15.90 10.76 34 73117 37340 34846440
Geotrichum infection 15.85 10.76 11 73140 493 34883287
Myelosuppression 15.84 10.76 81 73070 19184 34864596
Swelling face 15.80 10.76 15 73136 23090 34860690
Staphylococcal bacteraemia 15.66 10.76 46 73105 8406 34875374
Paraesthesia 15.62 10.76 75 73076 64097 34819683
Therapy cessation 15.60 10.76 8 73143 16965 34866815
Type 2 diabetes mellitus 15.58 10.76 7 73144 16025 34867755
Escherichia sepsis 15.57 10.76 32 73119 4672 34879108
Streptococcal infection 15.55 10.76 33 73118 4928 34878852
Arthritis 15.55 10.76 26 73125 31320 34852460
Anger 15.53 10.76 3 73148 11881 34871899
Pruritus genital 15.45 10.76 21 73130 2183 34881597
Pleural effusion 15.40 10.76 248 72903 81298 34802482
Myelodysplastic syndrome 15.27 10.76 80 73071 19128 34864652
Enterobacter test positive 15.27 10.76 8 73143 213 34883567
Anticonvulsant drug level abnormal 15.18 10.76 5 73146 38 34883742
Meningitis coccidioides 15.17 10.76 4 73147 12 34883768
Hepatomegaly 15.07 10.76 52 73099 10344 34873436
Hypertransaminasaemia 14.99 10.76 35 73116 5571 34878209
Oedema 14.98 10.76 154 72997 45587 34838193
Mucosal infection 14.94 10.76 8 73143 223 34883557
Balance disorder 14.90 10.76 40 73111 40614 34843166
Familial periodic paralysis 14.89 10.76 6 73145 85 34883695
Hepatic cytolysis 14.88 10.76 65 73086 14431 34869349
Lung neoplasm malignant 14.83 10.76 9 73142 17386 34866394
Dyspnoea exertional 14.82 10.76 44 73107 43235 34840545
Brachycephaly 14.77 10.76 6 73145 87 34883693
Mediastinitis 14.76 10.76 12 73139 684 34883096
Haematochezia 14.74 10.76 49 73102 46485 34837295
HIV associated nephropathy 14.72 10.76 9 73142 324 34883456
Hepatocellular injury 14.67 10.76 88 73063 22123 34861657
Nasal congestion 14.60 10.76 16 73135 23041 34860739
Generalised oedema 14.59 10.76 58 73093 12350 34871430
Pneumonia pseudomonal 14.57 10.76 28 73123 3894 34879886
Blood creatinine increased 14.42 10.76 279 72872 94697 34789083
Nosocomial infection 14.42 10.76 15 73136 1176 34882604
Cytomegalovirus test 14.34 10.76 5 73146 46 34883734
Dermatitis 14.29 10.76 48 73103 9420 34874360
Gastrointestinal wall thinning 14.28 10.76 4 73147 16 34883764
Culture stool positive 14.25 10.76 8 73143 245 34883535
Wheezing 14.24 10.76 42 73109 41360 34842420
Osteonecrosis of jaw 14.24 10.76 10 73141 17879 34865901
Pneumonia klebsiella 14.07 10.76 25 73126 3275 34880505
Faeces pale 14.07 10.76 16 73135 1387 34882393
Application site haematoma 14.06 10.76 5 73146 49 34883731
Rectal perforation 13.99 10.76 10 73141 470 34883310
Urinary tract inflammation 13.98 10.76 7 73144 169 34883611
Multiple sclerosis relapse 13.97 10.76 5 73146 13128 34870652
Rhinorrhoea 13.96 10.76 20 73131 25648 34858132
Pneumonia cryptococcal 13.95 10.76 13 73138 891 34882889
Bone marrow transplant 13.92 10.76 14 73137 1054 34882726
Enterococcus test positive 13.91 10.76 14 73137 1055 34882725
Venoocclusive disease 13.91 10.76 23 73128 2844 34880936
Heart rate increased 13.87 10.76 50 73101 46293 34837487
Enterobacter infection 13.87 10.76 21 73130 2409 34881371
Mycetoma mycotic 13.85 10.76 6 73145 103 34883677
Weight decreased 13.78 10.76 273 72878 176028 34707752
Sputum purulent 13.69 10.76 10 73141 486 34883294
Gram stain positive 13.69 10.76 6 73145 106 34883674
Pseudomonal bacteraemia 13.65 10.76 16 73135 1433 34882347
Prothrombin time prolonged 13.60 10.76 47 73104 9359 34874421
Peritoneal candidiasis 13.56 10.76 4 73147 20 34883760
Obesity 13.53 10.76 5 73146 12873 34870907
Somnolence 13.51 10.76 158 72993 110958 34772822
Contraindicated product administered 13.49 10.76 15 73136 21466 34862314
Organ failure 13.28 10.76 19 73132 2072 34881708
Gastroenteritis Escherichia coli 13.28 10.76 9 73142 388 34883392
Pseudomonas test positive 13.27 10.76 14 73137 1115 34882665
Basal cell carcinoma 13.17 10.76 13 73138 19645 34864135
Chronic lymphocytic leukaemia 13.09 10.76 28 73123 4204 34879576
Liver transplant rejection 13.08 10.76 19 73132 2100 34881680
Anaemia 13.05 10.76 605 72546 232730 34651050
Haemodialysis 13.02 10.76 50 73101 10476 34873304
Dysarthria 12.92 10.76 34 73117 34748 34849032
Nightmare 12.91 10.76 7 73144 14384 34869396
Cytomegalovirus enterocolitis 12.90 10.76 13 73138 981 34882799
Viral test positive 12.88 10.76 7 73144 201 34883579
Bone marrow disorder 12.88 10.76 17 73134 1718 34882062
Acute hepatic failure 12.87 10.76 61 73090 14013 34869767
Device malfunction 12.86 10.76 3 73148 10418 34873362
Meningism 12.82 10.76 7 73144 203 34883577
Hypoperfusion 12.73 10.76 14 73137 1169 34882611
Accidental overdose 12.72 10.76 14 73137 20126 34863654
Epstein-Barr virus infection 12.71 10.76 40 73111 7588 34876192
Skin cancer 12.64 10.76 3 73148 10294 34873486
Asthenia 12.63 10.76 404 72747 244847 34638933
High-grade B-cell lymphoma 12.62 10.76 6 73145 129 34883651
Post procedural bile leak 12.58 10.76 8 73143 309 34883471
Nephrolithiasis 12.57 10.76 28 73123 30305 34853475
Myalgia 12.52 10.76 114 73037 83996 34799784
Oesophagitis 12.51 10.76 58 73093 13203 34870577
CD4/CD8 ratio decreased 12.43 10.76 4 73147 28 34883752
Contusion 12.43 10.76 37 73114 36327 34847453
Toxic skin eruption 12.42 10.76 52 73099 11333 34872447
Blood creatine phosphokinase increased 12.39 10.76 50 73101 44807 34838973
Migraine 12.36 10.76 11 73140 17467 34866313
Respiratory paralysis 12.34 10.76 5 73146 72 34883708
Erectile dysfunction 12.33 10.76 15 73136 20622 34863158
Endocarditis candida 12.27 10.76 5 73146 73 34883707
Abdominal distension 12.21 10.76 72 73079 58420 34825360
Viraemia 12.21 10.76 14 73137 1224 34882556
Dermatitis exfoliative 12.17 10.76 36 73115 6603 34877177
Neurological symptom 12.16 10.76 27 73124 4158 34879622
Hepatitis fulminant 12.14 10.76 27 73124 4163 34879617
Hepatic cirrhosis 12.12 10.76 11 73140 17303 34866477
Hot flush 12.04 10.76 12 73139 18054 34865726
Metastases to bone 11.99 10.76 5 73146 11965 34871815
Constipation 11.98 10.76 208 72943 136774 34747006
Disseminated coccidioidomycosis 11.92 10.76 5 73146 79 34883701
Adult T-cell lymphoma/leukaemia 11.90 10.76 6 73145 147 34883633
Monocytopenia 11.86 10.76 5 73146 80 34883700
Therapy interrupted 11.80 10.76 7 73144 13690 34870090
Dystonia 11.75 10.76 4 73147 10841 34872939
Product quality issue 11.72 10.76 11 73140 17024 34866756
End stage AIDS 11.65 10.76 4 73147 35 34883745
Lymphopenia 11.61 10.76 66 73085 16269 34867511
Cytomegalovirus infection reactivation 11.61 10.76 30 73121 5088 34878692
T-cell lymphoma recurrent 11.55 10.76 4 73147 36 34883744
Delusion 11.54 10.76 6 73145 12629 34871151
Cholestatic liver injury 11.52 10.76 19 73132 2345 34881435
Psychotic disorder 11.47 10.76 21 73130 24431 34859349
Mycobacterial infection 11.46 10.76 19 73132 2355 34881425
HIV wasting syndrome 11.37 10.76 5 73146 89 34883691
ADAMTS13 activity decreased 11.32 10.76 5 73146 90 34883690
Arteriosclerosis coronary artery 11.30 10.76 6 73145 12479 34871301
Hyperthyroidism 11.27 10.76 4 73147 10562 34873218
Injection site swelling 11.26 10.76 5 73146 11522 34872258
Drug withdrawal syndrome 11.24 10.76 15 73136 19819 34863961
Eyelid ptosis congenital 11.22 10.76 5 73146 92 34883688
Citrobacter infection 11.21 10.76 9 73142 504 34883276
Laryngitis fungal 11.18 10.76 4 73147 40 34883740
Nervous system disorder 11.17 10.76 60 73091 14483 34869297
Gastroduodenal ulcer 11.12 10.76 8 73143 380 34883400
Haemorrhagic necrotic pancreatitis 11.05 10.76 6 73145 172 34883608
Sputum culture positive 10.99 10.76 16 73135 1772 34882008
Hypoxia 10.94 10.76 169 72982 54926 34828854
Anaphylactic reaction 10.94 10.76 33 73118 32268 34851512
Klebsiella bacteraemia 10.92 10.76 14 73137 1374 34882406
Streptococcal bacteraemia 10.92 10.76 17 73134 1998 34881782
Cholangitis infective 10.90 10.76 7 73144 275 34883505
Infectious pleural effusion 10.90 10.76 19 73132 2451 34881329
Poisoning 10.89 10.76 6 73145 12220 34871560
Central nervous system lesion 10.87 10.76 34 73117 6429 34877351
Candida test positive 10.86 10.76 8 73143 394 34883386
Spinal cord injury thoracic 10.84 10.76 5 73146 100 34883680

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 913.86 9.77 1537 139341 229462 79374048
Candida infection 599.65 9.77 515 140363 37699 79565811
Drug interaction 527.48 9.77 1771 139107 413412 79190098
Immune reconstitution inflammatory syndrome 369.85 9.77 256 140622 13585 79589925
Pancytopenia 367.04 9.77 866 140012 164879 79438631
Completed suicide 359.50 9.77 18 140860 245749 79357761
Cytokine release syndrome 349.02 9.77 372 140506 35626 79567884
Mucosal inflammation 337.51 9.77 532 140346 75048 79528462
Multiple organ dysfunction syndrome 315.09 9.77 672 140206 119574 79483936
Pyrexia 313.12 9.77 2159 138719 676550 78926960
Sepsis 303.90 9.77 1106 139772 268322 79335188
Mucormycosis 292.80 9.77 184 140694 8285 79595225
Thrombocytopenia 285.00 9.77 1072 139806 264187 79339323
Pathogen resistance 278.81 9.77 219 140659 14123 79589387
Neutropenia 266.58 9.77 1110 139768 286600 79316910
Septic shock 265.63 9.77 636 140242 122165 79481345
Platelet count decreased 251.37 9.77 836 140042 193828 79409682
Graft versus host disease 248.93 9.77 209 140669 14817 79588693
Arthralgia 247.51 9.77 393 140485 571410 79032100
Fungal infection 236.95 9.77 329 140549 41419 79562091
Cytomegalovirus infection 214.06 9.77 317 140561 42327 79561183
Aspergillus infection 210.91 9.77 212 140666 18949 79584561
Stevens-Johnson syndrome 199.26 9.77 293 140585 38873 79564637
Joint swelling 197.35 9.77 134 140744 288512 79314998
Neutrophil count decreased 194.97 9.77 479 140399 93480 79510030
Toxic epidermal necrolysis 192.34 9.77 309 140569 44272 79559238
Systemic candida 190.91 9.77 129 140749 6577 79596933
Synovitis 189.64 9.77 22 140856 150712 79452798
Aplastic anaemia 177.01 9.77 187 140691 17718 79585792
Enterococcal infection 175.55 9.77 175 140703 15485 79588025
Oral candidiasis 165.89 9.77 232 140646 29396 79574114
Hand deformity 164.39 9.77 4 140874 103915 79499595
Fall 163.98 9.77 389 140489 487240 79116270
Bronchopulmonary aspergillosis 162.84 9.77 199 140679 22095 79581415
Drug abuse 161.05 9.77 44 140834 162647 79440863
Drug resistance 158.59 9.77 275 140603 41938 79561572
Arthropathy 154.03 9.77 60 140818 177051 79426459
Therapeutic product effect decreased 148.41 9.77 52 140826 163811 79439699
Abdominal discomfort 146.69 9.77 136 140742 250591 79352919
Pemphigus 143.30 9.77 8 140870 99574 79503936
Rheumatoid arthritis 138.17 9.77 100 140778 208370 79395140
Systemic lupus erythematosus 137.64 9.77 24 140854 121125 79482385
Meningitis cryptococcal 133.46 9.77 81 140797 3425 79600085
Peripheral swelling 132.53 9.77 169 140709 269448 79334062
Acute myeloid leukaemia 130.39 9.77 212 140666 30673 79572837
Glossodynia 122.95 9.77 18 140860 103319 79500191
Intentional overdose 122.56 9.77 20 140858 105940 79497570
Fatigue 120.37 9.77 1058 139820 928669 78674841
Torsade de pointes 119.89 9.77 159 140719 19153 79584357
Drug intolerance 119.30 9.77 176 140702 263943 79339567
Musculoskeletal stiffness 118.53 9.77 82 140796 174926 79428584
Nasopharyngitis 117.80 9.77 166 140712 253715 79349795
Acute graft versus host disease 114.66 9.77 114 140764 10053 79593457
Tumour lysis syndrome 113.06 9.77 173 140705 23766 79579744
White blood cell count decreased 111.80 9.77 640 140238 187648 79415862
Pseudomonas infection 111.58 9.77 160 140718 20743 79582767
Plasma cell myeloma 110.95 9.77 272 140606 52987 79550523
Suicide attempt 109.73 9.77 10 140868 82922 79520588
Neurotoxicity 109.52 9.77 202 140676 32316 79571194
Contraindicated product administered 109.11 9.77 72 140806 157466 79446044
Cytomegalovirus viraemia 107.81 9.77 123 140755 12698 79590812
Respiratory failure 107.46 9.77 615 140263 180296 79423214
Wound 104.95 9.77 37 140841 116142 79487368
Pain 104.23 9.77 772 140106 703030 78900480
Drug level increased 103.05 9.77 221 140657 39430 79564080
Cryptococcosis 101.36 9.77 68 140810 3425 79600085
Immunosuppressant drug level increased 99.56 9.77 100 140778 8927 79594583
Fungaemia 97.73 9.77 74 140804 4517 79598993
Blood bilirubin increased 97.71 9.77 298 140580 65934 79537576
Swelling 96.30 9.77 146 140732 216565 79386945
Acute graft versus host disease in skin 96 9.77 91 140787 7567 79595943
Maternal exposure during pregnancy 95.10 9.77 62 140816 136476 79467034
Disseminated intravascular coagulation 94.57 9.77 201 140677 35641 79567869
Dizziness 94.29 9.77 545 140333 525896 79077614
Staphylococcal infection 93.32 9.77 270 140608 58025 79545485
Discomfort 91.70 9.77 54 140824 125563 79477947
Helicobacter infection 90.64 9.77 9 140869 69695 79533815
Oesophageal candidiasis 90.62 9.77 96 140782 9122 79594388
Duodenal ulcer perforation 90.30 9.77 7 140871 66204 79537306
Alopecia 89.79 9.77 170 140708 231185 79372325
Bacteraemia 88.83 9.77 186 140692 32638 79570872
Bone marrow failure 87.96 9.77 243 140635 50864 79552646
Pericarditis 84.69 9.77 39 140839 104197 79499313
Immune effector cell-associated neurotoxicity syndrome 82.04 9.77 74 140804 5774 79597736
Blood lactate dehydrogenase increased 81.53 9.77 200 140678 38970 79564540
Injection site pain 80.01 9.77 67 140811 129771 79473739
Dyspnoea 79.42 9.77 1053 139825 855972 78747538
Cystitis haemorrhagic 78.83 9.77 89 140789 9083 79594427
Sinusitis fungal 78.12 9.77 50 140828 2324 79601186
Clostridium difficile colitis 76.06 9.77 173 140705 32110 79571400
Female genital tract fistula 74.90 9.77 71 140807 5904 79597606
Salpingo-oophorectomy unilateral 74.20 9.77 34 140844 800 79602710
Leukopenia 73.73 9.77 403 140475 116110 79487400
Drug reaction with eosinophilia and systemic symptoms 73.29 9.77 265 140613 63979 79539531
Pneumonia fungal 72.22 9.77 94 140784 11116 79592394
Alanine aminotransferase increased 71.97 9.77 513 140365 162057 79441453
Bacterial sepsis 71.22 9.77 80 140798 8118 79595392
Electrocardiogram QT prolonged 70.80 9.77 332 140546 90054 79513456
Candida sepsis 70.72 9.77 48 140830 2465 79601045
Pneumonia 69.96 9.77 1591 139287 658655 78944855
Agranulocytosis 69.61 9.77 206 140672 44824 79558686
Irritable bowel syndrome 69.23 9.77 13 140865 62228 79541282
Acinetobacter infection 68.68 9.77 49 140829 2728 79600782
Hepatotoxicity 68.35 9.77 223 140655 51129 79552381
Fixed eruption 68.22 9.77 50 140828 2904 79600606
Laryngitis fungal 67.28 9.77 20 140858 126 79603384
Infusion related reaction 67.08 9.77 197 140681 230040 79373470
Hepatic function abnormal 66.67 9.77 281 140597 72826 79530684
Skin candida 66.32 9.77 43 140835 2044 79601466
Deep vein thrombosis 65.91 9.77 402 140476 120517 79482993
Aspartate aminotransferase increased 65.79 9.77 445 140433 138196 79465314
Toxicity to various agents 65.34 9.77 456 140422 421084 79182426
Impaired healing 64.94 9.77 37 140841 87618 79515892
Venoocclusive liver disease 64.14 9.77 91 140787 11680 79591830
Klebsiella infection 63.77 9.77 106 140772 15614 79587896
Inappropriate schedule of product administration 63.31 9.77 86 140792 133542 79469968
Haemophagocytic lymphohistiocytosis 62.93 9.77 127 140751 21710 79581800
Device related infection 61.94 9.77 166 140712 34128 79569382
Blood pressure increased 61.46 9.77 181 140697 211179 79392331
Systemic mycosis 61.28 9.77 45 140833 2621 79600889
Hyperbilirubinaemia 60.68 9.77 134 140744 24384 79579126
Acute generalised exanthematous pustulosis 60.40 9.77 109 140769 17145 79586365
Chronic graft versus host disease 60.33 9.77 67 140811 6714 79596796
Product dose omission issue 60.32 9.77 229 140649 247308 79356202
Neutropenic sepsis 59.33 9.77 141 140737 26923 79576587
Therapeutic product effect incomplete 58.59 9.77 100 140778 141545 79461965
Mobility decreased 58.52 9.77 78 140800 122097 79481413
Myocardial infarction 58.51 9.77 151 140727 183978 79419532
Mouth ulceration 57.79 9.77 174 140704 38220 79565290
Pain in extremity 57.13 9.77 393 140485 364145 79239365
Intentional product use issue 57.06 9.77 114 140764 151998 79451512
Blood alkaline phosphatase increased 56.73 9.77 243 140635 63421 79540089
Acute kidney injury 56.62 9.77 1257 139621 518147 79085363
Encephalitis 56.52 9.77 97 140781 14663 79588847
Hepatic failure 56.38 9.77 236 140642 60976 79542534
Renal failure 55.53 9.77 571 140307 200397 79403113
Vaginal discharge 55.11 9.77 67 140811 7396 79596114
Cytomegalovirus test positive 55.06 9.77 60 140818 5887 79597623
Loss of personal independence in daily activities 54.95 9.77 60 140818 102520 79500990
Cholestasis 54.47 9.77 209 140669 51900 79551610
Fibromyalgia 53.95 9.77 23 140855 64317 79539193
Acute myeloid leukaemia recurrent 53.86 9.77 46 140832 3337 79600173
Contusion 53.68 9.77 114 140764 148662 79454848
Psoriatic arthropathy 53.51 9.77 36 140842 77963 79525547
Drug ineffective for unapproved indication 53.14 9.77 205 140673 51033 79552477
Malaise 52.80 9.77 582 140296 489287 79114223
Toxic neuropathy 51.67 9.77 28 140850 952 79602558
Geotrichum infection 51.64 9.77 28 140850 953 79602557
Feeling abnormal 51.01 9.77 130 140748 159069 79444441
Engraftment syndrome 49.68 9.77 31 140847 1378 79602132
Wrong technique in product usage process 49.48 9.77 35 140843 73840 79529670
Rash maculo-papular 48.40 9.77 212 140666 55866 79547644
Hypertension 48.37 9.77 364 140514 330628 79272882
Infective aneurysm 48.19 9.77 27 140851 981 79602529
Overdose 47.77 9.77 166 140712 184040 79419470
Hypersensitivity 47.10 9.77 271 140607 261968 79341542
Graft versus host disease in gastrointestinal tract 46.84 9.77 57 140821 6299 79597211
Memory impairment 46.10 9.77 79 140799 111655 79491855
Weight increased 45.97 9.77 294 140584 277092 79326418
Uterine perforation 45.60 9.77 56 140822 6247 79597263
Embolism venous 45.00 9.77 46 140832 4193 79599317
Dermatitis bullous 44.86 9.77 86 140792 14159 79589351
Long QT syndrome 44.85 9.77 54 140824 5901 79597609
Blood cholesterol increased 44.81 9.77 49 140829 83671 79519839
Enterobacter infection 43.94 9.77 47 140831 4515 79598995
Dysbiosis 43.43 9.77 27 140851 1192 79602318
Blood pressure fluctuation 43.43 9.77 33 140845 67112 79536398
Enterococcal bacteraemia 43.39 9.77 39 140839 3029 79600481
HIV infection 42.80 9.77 26 140852 1101 79602409
Odynophagia 42.80 9.77 74 140804 11253 79592257
Sleep disorder 42.78 9.77 53 140825 85624 79517886
Penis injury 42.66 9.77 14 140864 127 79603383
Stem cell transplant 42.63 9.77 42 140836 3662 79599848
Knee arthroplasty 42.20 9.77 12 140866 43236 79560274
Renal impairment 42.01 9.77 445 140433 157338 79446172
Aplasia 41.94 9.77 60 140818 7760 79595750
Hypomagnesaemia 41.75 9.77 179 140699 46732 79556778
Epstein-Barr virus infection 41.73 9.77 84 140794 14332 79589178
Injection site erythema 41.59 9.77 46 140832 78151 79525359
Cerebral toxoplasmosis 41.50 9.77 34 140844 2328 79601182
Arthritis 41.46 9.77 88 140790 114792 79488718
Gamma-glutamyltransferase increased 41.46 9.77 199 140679 54481 79549029
Gait disturbance 41.37 9.77 207 140671 207299 79396211
Rhinorrhoea 41.29 9.77 44 140834 76030 79527480
Transplant rejection 41.25 9.77 100 140778 19337 79584173
Enterococcal sepsis 41.24 9.77 36 140842 2690 79600820
Respiratory tract infection fungal 41.04 9.77 26 140852 1187 79602323
Injection site swelling 40.89 9.77 16 140862 47116 79556394
Systemic inflammatory response syndrome 40.86 9.77 73 140805 11392 79592118
Dysphagia 40.64 9.77 361 140517 121775 79481735
Insomnia 40.54 9.77 260 140618 244910 79358600
Cytopenia 40.23 9.77 102 140776 20281 79583229
Myelosuppression 39.99 9.77 159 140719 40137 79563373
Nervous system disorder 39.75 9.77 121 140757 26735 79576775
Anaemia 39.68 9.77 1048 139830 443967 79159543
Type 2 diabetes mellitus 39.67 9.77 26 140852 57096 79546414
Gastrointestinal fungal infection 39.41 9.77 19 140859 503 79603007
Graft versus host disease in skin 39.24 9.77 51 140827 6022 79597488
Headache 39.04 9.77 869 140009 652903 78950607
Stress 38.96 9.77 50 140828 79562 79523948
Disseminated mucormycosis 38.41 9.77 21 140857 727 79602783
Sputum increased 38.35 9.77 44 140834 4569 79598941
Acute respiratory distress syndrome 38.34 9.77 167 140711 43900 79559610
Cutaneous coccidioidomycosis 38.21 9.77 9 140869 18 79603492
Hypokalaemia 37.76 9.77 405 140473 143635 79459875
Trichosporon infection 37.63 9.77 23 140855 985 79602525
Toxoplasmosis 37.58 9.77 34 140844 2663 79600847
Nocardiosis 37.18 9.77 48 140830 5631 79597879
Adverse event 37.17 9.77 31 140847 60183 79543327
Pulmonary haemorrhage 37.06 9.77 81 140797 14636 79588874
Oropharyngeal candidiasis 36.69 9.77 28 140850 1729 79601781
Foetal death 36.39 9.77 57 140821 7987 79595523
Staphylococcal bacteraemia 36.33 9.77 72 140806 12146 79591364
Cachexia 36.25 9.77 68 140810 11015 79592495
Gastrointestinal mucormycosis 36.15 9.77 17 140861 425 79603085
Folliculitis 36.09 9.77 27 140851 55353 79548157
Pseudomembranous colitis 36.09 9.77 46 140832 5328 79598182
Blood pressure systolic increased 36.07 9.77 39 140839 66947 79536563
Penile haemorrhage 35.93 9.77 18 140860 519 79602991
Eosinophilia 35.82 9.77 167 140711 45178 79558332
Blood culture positive 35.76 9.77 58 140820 8371 79595139
Fusarium infection 35.66 9.77 28 140850 1804 79601706
Breast cancer 35.61 9.77 8 140870 33773 79569737
International normalised ratio increased 35.54 9.77 264 140614 84457 79519053
Toxic skin eruption 35.42 9.77 103 140775 22190 79581320
Respiratory symptom 35.36 9.77 43 140835 4748 79598762
Human ehrlichiosis 35.30 9.77 18 140860 539 79602971
Blast cell count increased 35.15 9.77 25 140853 1385 79602125
Pleural effusion 35.13 9.77 402 140476 144860 79458650
Stenotrophomonas infection 34.81 9.77 38 140840 3735 79599775
Adenovirus infection 34.32 9.77 57 140821 8390 79595120
Acute lymphocytic leukaemia 34.11 9.77 43 140835 4926 79598584
Musculoskeletal pain 34.01 9.77 82 140796 102272 79501238
Ileus paralytic 33.96 9.77 61 140817 9559 79593951
Ill-defined disorder 33.68 9.77 40 140838 65835 79537675
Vulvovaginal candidiasis 33.68 9.77 31 140847 2483 79601027
Staphylococcal sepsis 33.67 9.77 78 140800 14648 79588862
Drug-induced liver injury 33.63 9.77 216 140662 65901 79537609
Disseminated cryptococcosis 33.49 9.77 27 140851 1807 79601703
Hepatitis cholestatic 33.48 9.77 75 140803 13777 79589733
Erythema multiforme 33.46 9.77 87 140791 17564 79585946
Fungal test positive 33.40 9.77 22 140856 1074 79602436
Jaundice 33.37 9.77 184 140694 53165 79550345
Flushing 33.22 9.77 66 140812 88202 79515308
Adrenal insufficiency 32.90 9.77 118 140760 28369 79575141
Rash erythematous 32.70 9.77 194 140684 57575 79545935
C-reactive protein abnormal 32.28 9.77 23 140855 48344 79555166
Nightmare 31.95 9.77 4 140874 25857 79577653
Basal cell carcinoma 31.91 9.77 13 140865 37362 79566148
Incorrect dose administered 31.77 9.77 54 140824 76576 79526934
Medication error 31.68 9.77 45 140833 68597 79534913
Diastolic dysfunction 31.30 9.77 63 140815 10748 79592762
Myelodysplastic syndrome 31.23 9.77 121 140757 30180 79573330
Paraesthesia 31.22 9.77 183 140695 176140 79427370
Intracranial pressure increased 30.96 9.77 54 140824 8268 79595242
Lymphocyte count decreased 30.86 9.77 165 140713 47124 79556386
Heart rate decreased 30.60 9.77 48 140830 70268 79533242
Suicidal ideation 30.56 9.77 55 140823 76285 79527225
Hyperferritinaemia 30.53 9.77 18 140860 721 79602789
Fungal oesophagitis 30.52 9.77 20 140858 968 79602542
Shock haemorrhagic 30.27 9.77 91 140787 19969 79583541
Hyperhidrosis 30.26 9.77 151 140727 151341 79452169
Coagulopathy 30.22 9.77 135 140743 35871 79567639
Mucosal disorder 29.92 9.77 34 140844 3494 79600016
Haemodialysis 29.89 9.77 85 140793 18083 79585427
Coccidioidomycosis 29.83 9.77 22 140856 1290 79602220
Brain abscess 29.65 9.77 40 140838 4896 79598614
Osteonecrosis of jaw 29.58 9.77 20 140858 43206 79560304
Cardiac failure congestive 29.56 9.77 140 140738 142262 79461248
Abdominal pain upper 29.51 9.77 253 140625 223566 79379944
Prostate cancer 29.35 9.77 11 140867 33257 79570253
Wound infection fungal 29.34 9.77 12 140866 212 79603298
Cytomegalovirus chorioretinitis 29.26 9.77 42 140836 5448 79598062
Haemodynamic instability 29.26 9.77 82 140796 17300 79586210
Rhinovirus infection 28.80 9.77 51 140827 7902 79595608
Cough 28.80 9.77 465 140413 366324 79237186
Engraft failure 28.50 9.77 17 140861 696 79602814
Vaginal infection 28.48 9.77 43 140835 5837 79597673
Sedation 28.18 9.77 30 140848 51865 79551645
Nasal congestion 28.16 9.77 58 140820 76494 79527016
Differentiation syndrome 27.91 9.77 28 140850 2496 79601014
Hypoalbuminaemia 27.90 9.77 92 140786 21205 79582305
Blood creatinine increased 27.75 9.77 406 140472 154651 79448859
Road traffic accident 27.55 9.77 22 140856 43642 79559868
Muscle spasms 27.51 9.77 188 140690 174542 79428968
Post procedural bile leak 27.43 9.77 14 140864 420 79603090
Fungal sepsis 27.35 9.77 24 140854 1806 79601704
Adverse drug reaction 27.33 9.77 47 140831 66345 79537165
Oral disorder 27.07 9.77 57 140821 10038 79593472
Graft versus host disease in lung 27.05 9.77 18 140860 894 79602616
Blood corticosterone increased 26.70 9.77 5 140873 0 79603510
Poisoning 26.61 9.77 6 140872 25266 79578244
Hip arthroplasty 26.61 9.77 15 140863 35741 79567769
Encephalopathy 26.57 9.77 207 140671 67190 79536320
Accidental exposure to product 26.57 9.77 11 140867 31311 79572199
Nephropathy toxic 26.56 9.77 88 140790 20331 79583179
Chronic sinusitis 26.56 9.77 66 140812 12960 79590550
Intentional self-injury 26.52 9.77 12 140866 32407 79571103
Joint stiffness 26.49 9.77 20 140858 40810 79562700
Disseminated coccidioidomycosis 26.44 9.77 10 140868 142 79603368
Aortoenteric fistula 26.38 9.77 10 140868 143 79603367
Enterobacter test positive 26.30 9.77 14 140864 459 79603051
Fungal peritonitis 26.27 9.77 19 140859 1081 79602429
Fungal skin infection 26.24 9.77 42 140836 5994 79597516
Candida test positive 26.17 9.77 19 140859 1087 79602423
Liver disorder 26.15 9.77 218 140660 72199 79531311
Colitis 26.11 9.77 220 140658 73087 79530423
Neutrophilic dermatosis 26.04 9.77 15 140863 575 79602935
Gastrointestinal disorder 26.04 9.77 119 140759 122086 79481424
Bradycardia 26.00 9.77 137 140741 135420 79468090
Intentional product misuse 25.86 9.77 84 140794 95081 79508429
Pain in jaw 25.83 9.77 26 140852 46125 79557385
Epidermolysis bullosa 25.78 9.77 11 140867 217 79603293
Mycobacterium avium complex infection 25.71 9.77 36 140842 4564 79598946
Pseudomonal sepsis 25.54 9.77 42 140836 6132 79597378
Injection site bruising 25.44 9.77 21 140857 40981 79562529
Philadelphia positive acute lymphocytic leukaemia 25.37 9.77 8 140870 63 79603447
Multiple-drug resistance 25.11 9.77 51 140827 8757 79594753
Cerebrovascular accident 24.99 9.77 166 140712 155126 79448384
Feeling hot 24.85 9.77 42 140836 59692 79543818
Sinus polyp 24.61 9.77 14 140864 524 79602986
Cholecystitis chronic 24.35 9.77 54 140824 9852 79593658
Therapeutic response decreased 24.29 9.77 51 140827 66802 79536708
Disease recurrence 24.24 9.77 147 140731 43962 79559548
Oesophagitis 24.22 9.77 96 140782 24193 79579317
Clostridium test positive 24.17 9.77 42 140836 6412 79597098
Pneumonia pseudomonal 24.17 9.77 40 140838 5871 79597639
Enterovirus infection 24.14 9.77 23 140855 1924 79601586
Nasal abscess 24.13 9.77 10 140868 183 79603327
Haematotoxicity 23.98 9.77 71 140807 15448 79588062
Jarisch-Herxheimer reaction 23.93 9.77 17 140861 940 79602570
Hypertensive crisis 23.83 9.77 4 140874 20766 79582744
Coronary artery disease 23.75 9.77 50 140828 65424 79538086
Klebsiella sepsis 23.70 9.77 29 140849 3223 79600287
Oral fungal infection 23.51 9.77 31 140847 3712 79599798
Injection site pruritus 23.46 9.77 24 140854 42259 79561251
Peripheral sensory neuropathy 23.45 9.77 63 140815 12970 79590540
Respiratory moniliasis 23.36 9.77 11 140867 276 79603234
Fracture 23.31 9.77 5 140873 21796 79581714
Stenotrophomonas test positive 23.24 9.77 12 140866 369 79603141
Death 23.17 9.77 794 140084 565720 79037790
Diffuse large B-cell lymphoma 23.15 9.77 60 140818 12089 79591421
Acute graft versus host disease in intestine 23.15 9.77 32 140846 4009 79599501
Septic embolus 23.13 9.77 23 140855 2028 79601482
Acute myocardial infarction 23.08 9.77 65 140813 76971 79526539
Product use issue 23.06 9.77 248 140630 209574 79393936
Obesity 23.05 9.77 17 140861 35108 79568402
Lymphopenia 23.01 9.77 111 140767 30446 79573064
Tonsillar haemorrhage 22.96 9.77 11 140867 287 79603223
Sepsis syndrome 22.88 9.77 20 140858 1497 79602013
Musculoskeletal disorder 22.77 9.77 5 140873 21443 79582067
Symmetrical drug-related intertriginous and flexural exanthema 22.76 9.77 16 140862 870 79602640
Atelectasis 22.74 9.77 115 140763 32142 79571368
Abscess neck 22.66 9.77 18 140860 1179 79602331
Acquired immunodeficiency syndrome 22.65 9.77 11 140867 296 79603214
Blood immunoglobulin M increased 22.62 9.77 19 140859 1347 79602163
Somnolence 22.59 9.77 292 140586 238689 79364821
Focal myositis 22.43 9.77 6 140872 24 79603486
Osteoarthritis 22.41 9.77 79 140799 87230 79516280
COVID-19 22.25 9.77 175 140703 157499 79446011
Neuropathy peripheral 22.22 9.77 362 140516 140943 79462567
Encephalitis viral 22.12 9.77 25 140853 2554 79600956
Chronic hepatitis C 22.10 9.77 14 140864 639 79602871
Extravasation blood 22.04 9.77 12 140866 412 79603098
Nosocomial infection 21.85 9.77 26 140852 2806 79600704
Nail infection 21.85 9.77 24 140854 2375 79601135
Drug dependence 21.66 9.77 24 140854 40745 79562765
Hepatic cirrhosis 21.51 9.77 18 140860 34888 79568622
Generalised oedema 21.50 9.77 91 140787 23618 79579892
Epidermolysis 21.49 9.77 16 140862 952 79602558
Bone erosion 21.48 9.77 3 140875 17844 79585666
Growth failure 21.41 9.77 10 140868 246 79603264
Joint neoplasm 21.38 9.77 7 140871 63 79603447
Red blood cell sedimentation rate increased 21.31 9.77 30 140848 45912 79557598
Pulmonary fibrosis 21.28 9.77 28 140850 44084 79559426
Hysterectomy 21.16 9.77 39 140839 6233 79597277
Chest pain 21.13 9.77 361 140517 281943 79321567
Irritability 21.01 9.77 25 140853 41119 79562391
Pulmonary mucormycosis 20.95 9.77 17 140861 1148 79602362
Restlessness 20.94 9.77 31 140847 46461 79557049
Weight decreased 20.89 9.77 473 140405 354725 79248785
Oral pain 20.78 9.77 111 140767 31687 79571823
Platelet transfusion 20.59 9.77 23 140855 2319 79601191
BK virus infection 20.53 9.77 47 140831 8757 79594753
Hepatocellular injury 20.35 9.77 149 140729 47444 79556066
Thrombotic microangiopathy 20.34 9.77 80 140798 20089 79583421
Right ventricular failure 20.34 9.77 8 140870 23489 79580021
Petechiae 20.28 9.77 81 140797 20484 79583026
Portal fibrosis 20.24 9.77 13 140865 608 79602902
Lung neoplasm malignant 20.20 9.77 12 140866 27780 79575730
Angina pectoris 20.05 9.77 38 140840 51694 79551816
Joint dislocation 20.03 9.77 3 140875 16936 79586574
CD4 lymphocytes decreased 20.03 9.77 24 140854 2610 79600900
Meningitis 20.01 9.77 49 140829 9533 79593977
Arthritis fungal 20.00 9.77 8 140870 133 79603377
Bladder cancer 19.84 9.77 5 140873 19521 79583989
Primary adrenal insufficiency 19.79 9.77 9 140869 208 79603302
Wound dehiscence 19.77 9.77 39 140839 6556 79596954
Metabolic acidosis 19.77 9.77 228 140650 82301 79521209
Respiratory distress 19.69 9.77 173 140705 58166 79545344
Skin lesion 19.64 9.77 134 140744 41710 79561800
Blood immunoglobulin A decreased 19.63 9.77 18 140860 1435 79602075
Asthenia 19.58 9.77 723 140155 510966 79092544
Inflammation 19.55 9.77 92 140786 93661 79509849
Trichoglossia 19.53 9.77 13 140865 646 79602864
Soft tissue neoplasm 19.50 9.77 7 140871 85 79603425
Pseudomonas test positive 19.48 9.77 20 140858 1832 79601678
Diabetic macroangiopathy 19.42 9.77 8 140870 144 79603366
Stiff person syndrome 19.24 9.77 10 140868 312 79603198
Nasal polyps 19.22 9.77 41 140837 7286 79596224
Pulmonary nocardiosis 19.20 9.77 17 140861 1294 79602216
Product prescribing error 19.11 9.77 31 140847 44782 79558728
Enterococcus test positive 19.08 9.77 21 140857 2083 79601427
Dystonia 19.00 9.77 7 140871 21392 79582118
Shock 19.00 9.77 137 140741 43411 79560099
Hot flush 19 9.77 43 140835 54834 79548676
Limb discomfort 18.97 9.77 18 140860 32832 79570678
Injection site mass 18.97 9.77 6 140872 20178 79583332
Proteus infection 18.97 9.77 21 140857 2097 79601413
Exposure via breast milk 18.91 9.77 15 140863 981 79602529
Vaginal flatulence 18.82 9.77 23 140855 2552 79600958
Cognitive disorder 18.81 9.77 62 140816 69864 79533646
Overgrowth fungal 18.80 9.77 7 140871 95 79603415
Live birth 18.66 9.77 5 140873 18739 79584771
Fat necrosis 18.57 9.77 14 140864 849 79602661
Mediastinitis 18.55 9.77 14 140864 850 79602660
Brain oedema 18.47 9.77 91 140787 25172 79578338
Choreoathetosis 18.44 9.77 18 140860 1552 79601958
Hepatosplenic candidiasis 18.40 9.77 12 140866 576 79602934
Liver abscess 18.39 9.77 36 140842 6018 79597492
Angioimmunoblastic T-cell lymphoma 18.38 9.77 11 140867 453 79603057
Emphysema 18.38 9.77 67 140811 16233 79587277
Lower limb fracture 18.37 9.77 9 140869 23206 79580304
Influenza like illness 18.32 9.77 65 140813 71642 79531868
Hepatitis fulminant 18.32 9.77 40 140838 7222 79596288
Depression 18.30 9.77 271 140607 216519 79386991
Streptococcal infection 18.28 9.77 45 140833 8785 79594725
Epstein-Barr viraemia 18.28 9.77 21 140857 2184 79601326
Dry eye 18.27 9.77 23 140855 36908 79566602
Urinary tract infection fungal 18.17 9.77 15 140863 1038 79602472
Rhinocerebral mucormycosis 18.11 9.77 15 140863 1043 79602467
Dry mouth 17.99 9.77 87 140791 87932 79515578
Mediastinal effusion 17.94 9.77 6 140872 58 79603452
Endocarditis candida 17.92 9.77 7 140871 109 79603401
Oxygen saturation decreased 17.84 9.77 144 140734 128903 79474607
Immunodeficiency 17.80 9.77 81 140797 21687 79581823
Pneumonia klebsiella 17.78 9.77 32 140846 5022 79598488
Encephalitis fungal 17.66 9.77 8 140870 183 79603327
Antithrombin III decreased 17.63 9.77 11 140867 489 79603021
Genital haemorrhage 17.57 9.77 36 140842 6219 79597291
Resorption bone increased 17.49 9.77 17 140861 1458 79602052
Muscle spasticity 17.49 9.77 8 140870 21467 79582043
Dysarthria 17.48 9.77 61 140817 67561 79535949
Myalgia 17.47 9.77 227 140651 185414 79418096
Venoocclusive disease 17.44 9.77 30 140848 4543 79598967
Clostridial infection 17.39 9.77 34 140844 5680 79597830
Chronic lymphocytic leukaemia 17.36 9.77 31 140847 4835 79598675
Anxiety 17.25 9.77 322 140556 248190 79355320
Mycotic endophthalmitis 17.24 9.77 8 140870 194 79603316
Ventricular tachycardia 17.20 9.77 130 140748 41805 79561705
T-cell lymphoma recurrent 17.17 9.77 6 140872 67 79603443
Pulmonary infarction 17.03 9.77 27 140851 3822 79599688
Bacterial infection 17.03 9.77 104 140774 31176 79572334
Lymphadenopathy 16.99 9.77 156 140722 53091 79550419
Pneumonia cryptococcal 16.92 9.77 17 140861 1518 79601992
Skin oedema 16.88 9.77 18 140860 1723 79601787
Proctitis 16.88 9.77 36 140842 6396 79597114
SARS-CoV-2 sepsis 16.84 9.77 7 140871 129 79603381
Throat irritation 16.84 9.77 29 140849 40917 79562593
Tongue blistering 16.70 9.77 17 140861 1542 79601968
Injection site warmth 16.66 9.77 3 140875 14804 79588706
Foot deformity 16.66 9.77 11 140867 24063 79579447
Pneumonia influenzal 16.64 9.77 23 140855 2881 79600629
Injection site reaction 16.58 9.77 46 140832 54739 79548771
Cytomegalovirus infection reactivation 16.56 9.77 43 140835 8673 79594837
Grip strength decreased 16.53 9.77 9 140869 21860 79581650
Fluorosis 16.51 9.77 7 140871 136 79603374
Plasma cell leukaemia 16.50 9.77 18 140860 1768 79601742
Puerperal pyrexia 16.49 9.77 5 140873 34 79603476
Multiple sclerosis relapse 16.49 9.77 36 140842 46497 79557013
Mycetoma mycotic 16.46 9.77 7 140871 137 79603373
Migraine 16.46 9.77 89 140789 87404 79516106
Tongue coated 16.45 9.77 16 140862 1373 79602137
Pulmonary alveolar haemorrhage 16.38 9.77 51 140827 11406 79592104
Blood beta-D-glucan increased 16.33 9.77 11 140867 558 79602952
Night sweats 16.32 9.77 43 140835 52052 79551458
Macule 16.32 9.77 23 140855 2934 79600576
Abscess 16.30 9.77 82 140796 22869 79580641
Balance disorder 16.24 9.77 105 140773 98752 79504758
Arteritis infective 16.14 9.77 6 140872 81 79603429
Dementia 16.10 9.77 12 140866 24647 79578863
Hospitalisation 16.04 9.77 99 140779 94137 79509373
HIV associated nephropathy 16.04 9.77 9 140869 328 79603182
Underdose 16.03 9.77 21 140857 33130 79570380
Vulvovaginal disorder 16.02 9.77 3 140875 0 79603510
Cushingoid 16.02 9.77 45 140833 9507 79594003
Device malfunction 15.96 9.77 9 140869 21439 79582071
Sedation complication 15.95 9.77 4 140874 15665 79587845
Epstein-Barr virus associated lymphoproliferative disorder 15.94 9.77 25 140853 3507 79600003
Leukaemia recurrent 15.94 9.77 22 140856 2752 79600758
Cytomegalovirus gastroenteritis 15.83 9.77 10 140868 454 79603056
Lung infiltration 15.67 9.77 81 140797 22831 79580679
Renal abscess 15.67 9.77 14 140864 1079 79602431
Fungal endocarditis 15.57 9.77 11 140867 603 79602907
Hyperadrenocorticism 15.56 9.77 9 140869 348 79603162
Renal tubular acidosis 15.51 9.77 25 140853 3589 79599921
Chronic obstructive pulmonary disease 15.46 9.77 88 140790 85331 79518179
Culture stool positive 15.46 9.77 11 140867 610 79602900
Inhibitory drug interaction 15.42 9.77 28 140850 4425 79599085
Neurological symptom 15.34 9.77 42 140836 8741 79594769
IVth nerve paralysis 15.34 9.77 7 140871 163 79603347
Virologic failure 15.34 9.77 27 140851 4164 79599346
Coagulation factor V level decreased 15.30 9.77 11 140867 620 79602890
Pruritus genital 15.27 9.77 28 140850 4458 79599052
Heart rate increased 15.22 9.77 138 140740 120586 79482924
Acid base balance abnormal 15.21 9.77 9 140869 363 79603147
Lupus-like syndrome 15.18 9.77 3 140875 13854 79589656
Pulmonary embolism 15.18 9.77 404 140474 171250 79432260
Pallor 15.17 9.77 42 140836 50020 79553490
Acanthosis 15.17 9.77 10 140868 489 79603021
Herpes simplex oesophagitis 15.10 9.77 9 140869 368 79603142
Neutropenic colitis 15.04 9.77 32 140846 5675 79597835
Nausea 15.01 9.77 1472 139406 955724 78647786
Joint injury 15 9.77 20 140858 31315 79572195
Disease progression 14.92 9.77 429 140449 183933 79419577
Immunosuppressant drug level decreased 14.81 9.77 18 140860 1986 79601524
Cytomegalovirus test 14.80 9.77 5 140873 50 79603460
Fibrin degradation products increased 14.80 9.77 9 140869 382 79603128
Prothrombin time shortened 14.78 9.77 23 140855 3205 79600305
Mastitis fungal 14.76 9.77 4 140874 17 79603493
PRIDE syndrome 14.76 9.77 4 140874 17 79603493
Middle insomnia 14.71 9.77 5 140873 16064 79587446
Psychotic disorder 14.69 9.77 32 140846 41370 79562140
Liver transplant rejection 14.67 9.77 23 140855 3225 79600285
Cardio-respiratory arrest 14.58 9.77 122 140756 108388 79495122
Lung disorder 14.57 9.77 83 140795 80474 79523036
Hepatomegaly 14.53 9.77 69 140809 18805 79584705
Adrenal suppression 14.52 9.77 15 140863 1384 79602126
Heart rate irregular 14.51 9.77 22 140856 32657 79570853
Temperature regulation disorder 14.49 9.77 32 140846 5821 79597689
Staphylococcus test positive 14.46 9.77 34 140844 6447 79597063
Wheezing 14.43 9.77 134 140744 116530 79486980
Leukaemic infiltration extramedullary 14.43 9.77 7 140871 188 79603322
Product substitution issue 14.37 9.77 9 140869 20247 79583263
Presyncope 14.35 9.77 32 140846 41022 79562488
Gastritis fungal 14.32 9.77 7 140871 191 79603319
Osteomyelitis fungal 14.30 9.77 8 140870 290 79603220
Acute febrile neutrophilic dermatosis 14.24 9.77 25 140853 3847 79599663
Peritoneal candidiasis 14.23 9.77 4 140874 20 79603490
Gastrointestinal wall thinning 14.23 9.77 4 140874 20 79603490
Bone marrow disorder 14.18 9.77 23 140855 3320 79600190
Exostosis 14.17 9.77 6 140872 16852 79586658
Drug eruption 14.16 9.77 129 140749 43806 79559704
Injection site haemorrhage 14.16 9.77 17 140861 27853 79575657
Vulvovaginitis 14.12 9.77 8 140870 297 79603213
Pulmonary cavitation 14.11 9.77 16 140862 1640 79601870
Central nervous system leukaemia 14.09 9.77 9 140869 417 79603093
Kidney transplant rejection 14.09 9.77 45 140833 10201 79593309
Posterior reversible encephalopathy syndrome 14.07 9.77 87 140791 26194 79577316
Pharyngeal stenosis 14.07 9.77 4 140874 21 79603489
Pancreatitis 14.06 9.77 184 140694 68391 79535119
Chest discomfort 14.04 9.77 166 140712 137878 79465632
Hypoglossal nerve paresis 14.03 9.77 6 140872 119 79603391
Skin exfoliation 14.00 9.77 154 140724 54946 79548564
Metapneumovirus pneumonia 13.98 9.77 5 140873 60 79603450
Limb injury 13.98 9.77 19 140859 29509 79574001
Escherichia infection 13.97 9.77 66 140812 17951 79585559
Vaginal mucosal blistering 13.95 9.77 3 140875 3 79603507
Splenomegaly 13.94 9.77 73 140805 20681 79582829
Gallstone ileus 13.91 9.77 4 140874 22 79603488
CD4/CD8 ratio decreased 13.91 9.77 5 140873 61 79603449
Prothrombin time prolonged 13.91 9.77 63 140815 16836 79586674
Influenza 13.91 9.77 154 140724 129452 79474058
Scedosporium infection 13.84 9.77 15 140863 1463 79602047
Hepatic enzyme increased 13.82 9.77 233 140645 182377 79421133
Lip dry 13.76 9.77 5 140873 15413 79588097
Blood pressure diastolic decreased 13.75 9.77 20 140858 30196 79573314
Hepatosplenomegaly 13.71 9.77 32 140846 6037 79597473
Cerebral fungal infection 13.69 9.77 9 140869 438 79603072
Poor quality sleep 13.65 9.77 12 140866 22710 79580800
Dermatitis 13.64 9.77 74 140804 21247 79582263
Condition aggravated 13.63 9.77 735 140143 500389 79103121
Phalangeal hypoplasia 13.62 9.77 4 140874 24 79603486
Anal candidiasis 13.62 9.77 4 140874 24 79603486
Impaired work ability 13.61 9.77 9 140869 19672 79583838
Respiratory syncytial virus infection 13.58 9.77 42 140836 9360 79594150
Anticonvulsant drug level abnormal 13.55 9.77 5 140873 66 79603444
Ocular icterus 13.54 9.77 30 140848 5470 79598040
Cytomegalovirus oesophagitis 13.48 9.77 11 140867 749 79602761
Acquired macroglossia 13.48 9.77 7 140871 218 79603292
Periorbital cellulitis 13.45 9.77 12 140866 923 79602587
Hypertransaminasaemia 13.43 9.77 49 140829 11875 79591635
Hypogonadism 13.32 9.77 16 140862 1744 79601766
Cardiovascular insufficiency 13.31 9.77 21 140857 2960 79600550
High-grade B-cell lymphoma 13.30 9.77 6 140872 136 79603374
Joint range of motion decreased 13.30 9.77 24 140854 33258 79570252
Blood immunoglobulin G increased 13.27 9.77 21 140857 2968 79600542
Delusion 13.25 9.77 10 140868 20413 79583097
Hypoxia 13.20 9.77 256 140622 102987 79500523
Aggression 13.15 9.77 46 140832 50912 79552598
Leukaemia 13.13 9.77 31 140847 5894 79597616
Visual impairment 13.11 9.77 102 140776 92029 79511481
Gram stain positive 13.10 9.77 6 140872 141 79603369
Application site haematoma 13.10 9.77 5 140873 73 79603437
Cerebral aspergillosis 13.06 9.77 16 140862 1780 79601730
Anger 13.06 9.77 7 140871 17155 79586355
HIV-associated neurocognitive disorder 13.06 9.77 8 140870 344 79603166
Angiodermatitis 13.03 9.77 5 140873 74 79603436
Blood sodium decreased 13.03 9.77 102 140776 33153 79570357
Drug withdrawal syndrome 13.02 9.77 26 140852 34692 79568818
Disability 13.00 9.77 7 140871 17113 79586397
Withdrawal syndrome 13.00 9.77 17 140861 26837 79576673
Gingival ulceration 13.00 9.77 12 140866 965 79602545
Full blood count abnormal 12.99 9.77 33 140845 40441 79563069
Conductive deafness 12.92 9.77 7 140871 238 79603272
Panniculitis 12.90 9.77 3 140875 12368 79591142
Herpes simplex 12.83 9.77 49 140829 12138 79591372
Post transplant lymphoproliferative disorder 12.82 9.77 47 140831 11417 79592093
Cushing's syndrome 12.81 9.77 12 140866 983 79602527
Hypogammaglobulinaemia 12.76 9.77 51 140827 12900 79590610
Infective chondritis 12.74 9.77 4 140874 31 79603479
Haemorrhage 12.71 9.77 229 140649 90889 79512621
Thrombotic thrombocytopenic purpura 12.68 9.77 32 140846 6344 79597166
Central nervous system lesion 12.66 9.77 52 140826 13316 79590194
Ischaemic hepatitis 12.64 9.77 23 140855 3641 79599869
Metastases to liver 12.63 9.77 19 140859 28295 79575215
Dermatitis exfoliative 12.63 9.77 45 140833 10784 79592726
General physical health deterioration 12.60 9.77 380 140498 274858 79328652
Congenital foot malformation 12.52 9.77 4 140874 33 79603477
Unevaluable event 12.52 9.77 53 140825 55532 79547978
Hyperleukocytosis 12.52 9.77 19 140859 2591 79600919
Respiratory paralysis 12.51 9.77 5 140873 83 79603427
Vulvovaginal mycotic infection 12.50 9.77 26 140852 4540 79598970
Back pain 12.48 9.77 426 140452 303754 79299756
Mucosal infection 12.47 9.77 9 140869 510 79603000
Gastric disorder 12.42 9.77 30 140848 37403 79566107
Blood test abnormal 12.38 9.77 8 140870 17702 79585808
Rash morbilliform 12.37 9.77 31 140847 6119 79597391
Bone marrow transplant 12.36 9.77 14 140864 1434 79602076
Pneumonitis 12.35 9.77 163 140715 60697 79542813
Graft loss 12.33 9.77 12 140866 1031 79602479
Aplasia pure red cell 12.33 9.77 36 140842 7774 79595736
Metastases to bone 12.31 9.77 15 140863 24412 79579098
Purpura senile 12.30 9.77 9 140869 521 79602989
Syncope 12.30 9.77 233 140645 179216 79424294
Infectious pleural effusion 12.28 9.77 23 140855 3721 79599789
Organ failure 12.27 9.77 24 140854 4009 79599501
Leukocytosis 12.23 9.77 124 140754 43331 79560179
Tarsal tunnel syndrome 12.21 9.77 9 140869 527 79602983
Gastrointestinal necrosis 12.20 9.77 29 140849 5536 79597974
Blood albumin decreased 12.20 9.77 79 140799 24164 79579346
Carpal tunnel syndrome 12.12 9.77 10 140868 19518 79583992
Faeces pale 12.11 9.77 20 140858 2930 79600580
Poikiloderma 12.07 9.77 8 140870 395 79603115
Vertigo 12.06 9.77 72 140806 69010 79534500
Leukoencephalopathy 11.99 9.77 36 140842 7893 79595617
Heparin-induced thrombocytopenia 11.95 9.77 41 140837 9641 79593869
Gastrooesophageal reflux disease 11.94 9.77 122 140756 104124 79499386
Acute lymphocytic leukaemia recurrent 11.89 9.77 26 140852 4698 79598812
Gallbladder fibrosis 11.88 9.77 3 140875 9 79603501
Viral test positive 11.84 9.77 8 140870 408 79603102
Product administration error 11.82 9.77 24 140854 31822 79571688
Rectal perforation 11.81 9.77 11 140867 894 79602616
Refractory anaemia with an excess of blasts 11.80 9.77 11 140867 895 79602615
Product storage error 11.80 9.77 7 140871 16219 79587291
Thrombophlebitis 11.78 9.77 31 140847 6304 79597206
Superinfection bacterial 11.77 9.77 14 140864 1510 79602000
Small intestinal perforation 11.76 9.77 21 140857 3276 79600234
Graft versus host disease in liver 11.76 9.77 15 140863 1739 79601771
Porphyria acute 11.69 9.77 14 140864 1521 79601989
Blood fibrinogen increased 11.65 9.77 15 140863 1755 79601755
Streptococcal bacteraemia 11.64 9.77 22 140856 3584 79599926
Vanishing bile duct syndrome 11.59 9.77 15 140863 1763 79601747
Serum ferritin increased 11.55 9.77 41 140837 9806 79593704
Aspartate aminotransferase 11.54 9.77 9 140869 574 79602936
Chronic myeloid leukaemia recurrent 11.49 9.77 7 140871 298 79603212
Palpitations 11.48 9.77 156 140722 126454 79477056
Red blood cell schistocytes present 11.46 9.77 9 140869 580 79602930
Pruritus 11.45 9.77 575 140303 394073 79209437
Hepatic artery aneurysm 11.42 9.77 4 140874 45 79603465
Erythroblast count increased 11.42 9.77 3 140875 11 79603499
Meningitis coccidioides 11.34 9.77 4 140874 46 79603464
Poor peripheral circulation 11.31 9.77 22 140856 3661 79599849
Vision blurred 11.29 9.77 126 140752 105772 79497738
Heliotrope rash 11.29 9.77 6 140872 196 79603314
Oedema genital 11.23 9.77 9 140869 597 79602913
Cardiac disorder 11.23 9.77 69 140809 65688 79537822
Urinary tract candidiasis 11.23 9.77 10 140868 767 79602743
Interstitial lung disease 11.22 9.77 136 140742 112464 79491046
Vulvovaginal discomfort 11.20 9.77 15 140863 1823 79601687
Hallucination, tactile 11.19 9.77 9 140869 600 79602910
Eye irritation 11.18 9.77 12 140866 20669 79582841
Citrobacter infection 11.17 9.77 11 140867 959 79602551
Failure to thrive 11.16 9.77 46 140832 11798 79591712
Pancreatic carcinoma 11.15 9.77 5 140873 13572 79589938
Hiatus hernia 11.15 9.77 75 140803 23237 79580273
Diverticulum 11.14 9.77 54 140824 14842 79588668
Enterocolitis 11.13 9.77 53 140825 14459 79589051
Duodenal stenosis 11.12 9.77 10 140868 777 79602733
Disturbance in attention 11.10 9.77 49 140829 50752 79552758
Anaphylactic shock 11.06 9.77 30 140848 35966 79567544
Stoma site candida 11.02 9.77 3 140875 13 79603497
Vulvovaginal pruritus 11.01 9.77 18 140860 2615 79600895
Food allergy 10.97 9.77 43 140835 10781 79592729
Oesophageal carcinoma 10.95 9.77 3 140875 11081 79592429
Skin hyperpigmentation 10.90 9.77 33 140845 7270 79596240
Splenic vein thrombosis 10.87 9.77 10 140868 800 79602710
Cytomegalovirus enterocolitis 10.85 9.77 14 140864 1641 79601869
Pulmonary arterial hypertension 10.85 9.77 21 140857 28345 79575165
Retroviral infection 10.84 9.77 3 140875 14 79603496
Hyperthyroidism 10.81 9.77 14 140864 22195 79581315
Autoimmune haemolytic anaemia 10.80 9.77 36 140842 8344 79595166
Adult T-cell lymphoma/leukaemia 10.79 9.77 7 140871 333 79603177
Angina bullosa haemorrhagica 10.78 9.77 6 140872 215 79603295
Hepatic necrosis 10.77 9.77 38 140840 9062 79594448
Secondary amyloidosis 10.76 9.77 6 140872 216 79603294
Scopulariopsis infection 10.74 9.77 5 140873 122 79603388
Mycobacterium abscessus infection 10.74 9.77 12 140866 1210 79602300
Flatulence 10.73 9.77 39 140839 42685 79560825
Product use in unapproved indication 10.72 9.77 543 140335 249816 79353694
Spinal cord injury thoracic 10.71 9.77 5 140873 123 79603387
Varicella zoster virus infection 10.68 9.77 24 140854 4417 79599093
Transmission of an infectious agent via transplant 10.67 9.77 3 140875 15 79603495
Cystic fibrosis related diabetes 10.66 9.77 6 140872 220 79603290
Abdominal distension 10.64 9.77 148 140730 119502 79484008
Lichenification 10.63 9.77 10 140868 823 79602687
Loss of consciousness 10.62 9.77 221 140657 167722 79435788
Gastroenteritis Escherichia coli 10.62 9.77 9 140869 646 79602864
Immune reconstitution inflammatory syndrome associated tuberculosis 10.60 9.77 10 140868 826 79602684
Necrotising retinitis 10.56 9.77 12 140866 1233 79602277
Periostitis 10.56 9.77 9 140869 651 79602859
Mania 10.55 9.77 10 140868 18250 79585260
Oral mucosa erosion 10.53 9.77 15 140863 1932 79601578
Sopor 10.53 9.77 27 140851 32983 79570527
Xanthopsia 10.52 9.77 7 140871 348 79603162
Klebsiella bacteraemia 10.51 9.77 19 140859 2991 79600519
Peripheral sensorimotor neuropathy 10.51 9.77 19 140859 2991 79600519
Red cell distribution width increased 10.50 9.77 7 140871 15235 79588275
Secondary adrenocortical insufficiency 10.50 9.77 19 140859 2995 79600515
Urticaria 10.49 9.77 248 140630 184953 79418557
Hyperuricaemia 10.48 9.77 45 140833 11754 79591756
Escherichia sepsis 10.48 9.77 36 140842 8472 79595038
Acanthamoeba infection 10.44 9.77 8 140870 497 79603013
Ureaplasma infection 10.44 9.77 11 140867 1039 79602471
Metastases to lung 10.43 9.77 10 140868 18153 79585357
Klebsiella test positive 10.41 9.77 14 140864 1709 79601801
Blood chloride increased 10.38 9.77 26 140852 5130 79598380
Renal tubular disorder 10.33 9.77 30 140848 6456 79597054
Tachypnoea 10.26 9.77 94 140784 31969 79571541
Transaminases increased 10.26 9.77 138 140740 51605 79551905
Joint effusion 10.25 9.77 10 140868 18004 79585506
Premature delivery 10.23 9.77 16 140862 23451 79580059
Acute sinusitis 10.22 9.77 24 140854 4546 79598964
Hypofibrinogenaemia 10.21 9.77 15 140863 1987 79601523
Haemolytic anaemia 10.18 9.77 60 140818 17760 79585750
Ankle fracture 10.15 9.77 9 140869 16960 79586550
Aeromonas infection 10.15 9.77 7 140871 369 79603141
Hallucinations, mixed 10.13 9.77 31 140847 6868 79596642
Pulmonary necrosis 10.10 9.77 8 140870 522 79602988
Gastroenteritis norovirus 10.09 9.77 19 140859 3087 79600423
Myocarditis toxoplasmal 10.09 9.77 4 140874 65 79603445
Respiratory arrest 10.03 9.77 60 140818 57490 79546020
Eschar 10.01 9.77 12 140866 1306 79602204
Enthesopathy 9.97 9.77 4 140874 11604 79591906
Blood glucose increased 9.95 9.77 143 140735 114832 79488678
Pulmonary hilum mass 9.94 9.77 6 140872 251 79603259
Rash pustular 9.94 9.77 43 140835 11268 79592242
Blastomycosis 9.89 9.77 9 140869 710 79602800
Viral haemorrhagic cystitis 9.88 9.77 15 140863 2046 79601464
Urinary tract inflammation 9.88 9.77 6 140872 254 79603256
Chronic graft versus host disease in skin 9.83 9.77 13 140865 1561 79601949
Chronic myeloid leukaemia transformation 9.81 9.77 6 140872 257 79603253
Clostridium difficile infection 9.81 9.77 117 140761 42568 79560942

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 55.15 29.94 34 210 1018 88530

Pharmacologic Action:

SourceCodeDescription
ATC D01AC15 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC J01RA07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J02AC01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
Triazole and tetrazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50183 P450 inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
MeSH PA D058888 14-alpha Demethylase Inhibitors
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D065689 Cytochrome P-450 CYP2C19 Inhibitors
MeSH PA D065688 Cytochrome P-450 CYP2C9 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006727 Hormone Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D065088 Steroid Synthesis Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cryptococcal meningitis indication 14232007
Candidiasis of the esophagus indication 20639004 DOID:13146
Mucocutaneous candidiasis indication 29147005
Disseminated candidiasis indication 70572005
Candidal vulvovaginitis indication 72605008 DOID:2272
Candidiasis of mouth indication 79740000 DOID:14262
Candidal septicemia indication 187022007
Candidemia indication 432261003
Prevention of Disseminated Candidiasis indication
Candidal Urinary Tract Infection indication
Oropharyngeal Candidiasis indication
Tinea capitis off-label use 5441008
Tinea pedis off-label use 6020002 DOID:12403
Histoplasmosis off-label use 12962009 DOID:1731
Tinea manus off-label use 48971001 DOID:13369
Pityriasis versicolor off-label use 56454009 DOID:9060
Blastomycosis off-label use 69996000 DOID:12663
Tinea corporis off-label use 84849002
Disseminated coccidioidomycosis off-label use 85055004
Cutaneous leishmaniasis off-label use 240637006 DOID:9111
Tinea cruris off-label use 399029005
Onychomycosis due to dermatophyte off-label use 402134005
Pulmonary coccidioidomycosis off-label use 417018008
Onychomycosis due to Candida off-label use
Prevention of Vulvovaginal Candidiasis off-label use
Kidney disease contraindication 90708001 DOID:557
Prolonged QT interval contraindication 111975006
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.55 acidic
pKa2 1.84 Basic
pKa3 1.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 4.54 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.09 CHEMBL
Lanosterol 14-alpha demethylase Enzyme Kd 4.40 CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.10 CHEMBL
Lanosterol 14-alpha demethylase Enzyme INHIBITOR IC50 6.70 WOMBAT-PK CHEMBL
Lanosterol 14-alpha demethylase Enzyme Kd 6.70 CHEMBL
14-alpha sterol demethylase Cyp51A Enzyme Kd 4.92 CHEMBL
14-alpha sterol demethylase Enzyme Kd 5.39 CHEMBL
Mycocyclosin synthase Enzyme Kd 5.22 CHEMBL
Sterol 14-alpha demethylase Enzyme IC50 6.06 CHEMBL

External reference:

IDSource
4019493 VUID
N0000147613 NUI
D00322 KEGG_DRUG
4019493 VANDF
C0016277 UMLSCUI
CHEBI:46081 CHEBI
TPF PDB_CHEM_ID
CHEMBL106 ChEMBL_ID
DB00196 DRUGBANK_ID
D015725 MESH_DESCRIPTOR_UI
3365 PUBCHEM_CID
5851 INN_ID
8VZV102JFY UNII
202813 RXNORM
3884 MMSL
4732 MMSL
59176 MMSL
d00071 MMSL
003534 NDDF
31865003 SNOMEDCT_US
387174006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3410 TABLET 50 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3420 TABLET 100 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3430 TABLET 200 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3440 POWDER, FOR SUSPENSION 350 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3450 POWDER, FOR SUSPENSION 1400 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 27 sections
Diflucan HUMAN PRESCRIPTION DRUG LABEL 1 0049-3500 TABLET 150 mg ORAL NDA 27 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9666 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9666 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9667 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9667 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9668 INJECTION 2 mg INTRAVENOUS ANDA 21 sections
Fluconazole HUMAN PRESCRIPTION DRUG LABEL 1 0143-9668 INJECTION 2 mg INTRAVENOUS ANDA 21 sections