cefepime 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 535 | 88040-23-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 4 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 85 % | Benet LZ, Broccatelli F, Oprea TI |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.28 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.78 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 18, 1996 | FDA | HOSPIRA INC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Encephalopathy | 462.19 | 18.80 | 217 | 16214 | 38403 | 63434188 |
| Acute kidney injury | 337.13 | 18.80 | 376 | 16055 | 263039 | 63209552 |
| Febrile neutropenia | 294.20 | 18.80 | 244 | 16187 | 118205 | 63354386 |
| Neurotoxicity | 239.25 | 18.80 | 107 | 16324 | 16883 | 63455708 |
| Drug reaction with eosinophilia and systemic symptoms | 219.15 | 18.80 | 126 | 16305 | 33710 | 63438881 |
| Status epilepticus | 208.31 | 18.80 | 94 | 16337 | 15139 | 63457452 |
| Multiple organ dysfunction syndrome | 172.95 | 18.80 | 132 | 16299 | 56620 | 63415971 |
| Cytokine release syndrome | 160.51 | 18.80 | 77 | 16354 | 14237 | 63458354 |
| Myoclonus | 144.22 | 18.80 | 74 | 16357 | 15794 | 63456797 |
| Sepsis | 143.44 | 18.80 | 187 | 16244 | 152936 | 63319655 |
| Acute generalised exanthematous pustulosis | 140.74 | 18.80 | 65 | 16366 | 11034 | 63461557 |
| Pyrexia | 137.61 | 18.80 | 345 | 16086 | 470133 | 63002458 |
| Septic shock | 132.32 | 18.80 | 121 | 16310 | 66508 | 63406083 |
| Thrombocytopenia | 131.41 | 18.80 | 178 | 16253 | 150979 | 63321612 |
| Mental status changes | 107.37 | 18.80 | 86 | 16345 | 39513 | 63433078 |
| Pain | 103.18 | 18.80 | 32 | 16399 | 740596 | 62731995 |
| Respiratory failure | 100.94 | 18.80 | 128 | 16303 | 101730 | 63370861 |
| Toxic encephalopathy | 91.19 | 18.80 | 41 | 16390 | 6538 | 63466053 |
| Tubulointerstitial nephritis | 87.67 | 18.80 | 58 | 16373 | 19845 | 63452746 |
| Neutropenia | 85.10 | 18.80 | 158 | 16273 | 174847 | 63297744 |
| Arthralgia | 80.34 | 18.80 | 24 | 16407 | 569686 | 62902905 |
| Clostridium difficile colitis | 76.51 | 18.80 | 54 | 16377 | 20515 | 63452076 |
| Immune effector cell-associated neurotoxicity syndrome | 73.07 | 18.80 | 26 | 16405 | 2251 | 63470340 |
| Fatigue | 72.71 | 18.80 | 74 | 16357 | 887954 | 62584637 |
| Klebsiella infection | 69.40 | 18.80 | 37 | 16394 | 8529 | 63464062 |
| Neutrophil count decreased | 67.44 | 18.80 | 78 | 16353 | 56328 | 63416263 |
| Pneumonia | 66.17 | 18.80 | 263 | 16168 | 456504 | 63016087 |
| Shock | 65.81 | 18.80 | 52 | 16379 | 23411 | 63449180 |
| Abdominal discomfort | 64.18 | 18.80 | 5 | 16426 | 320880 | 63151711 |
| Platelet count decreased | 62.98 | 18.80 | 110 | 16321 | 116012 | 63356579 |
| Alopecia | 62.88 | 18.80 | 7 | 16424 | 337529 | 63135062 |
| Hypoxia | 62.15 | 18.80 | 77 | 16354 | 59715 | 63412876 |
| Drug resistance | 60.43 | 18.80 | 49 | 16382 | 22884 | 63449707 |
| Bacteraemia | 58.69 | 18.80 | 43 | 16388 | 17305 | 63455286 |
| Pathogen resistance | 58.59 | 18.80 | 30 | 16401 | 6368 | 63466223 |
| Renal tubular necrosis | 55.69 | 18.80 | 36 | 16395 | 11842 | 63460749 |
| Mixed liver injury | 54.67 | 18.80 | 26 | 16405 | 4709 | 63467882 |
| Nasopharyngitis | 53.66 | 18.80 | 3 | 16428 | 254254 | 63218337 |
| Drug intolerance | 53.63 | 18.80 | 8 | 16423 | 308653 | 63163938 |
| Acute respiratory distress syndrome | 53.15 | 18.80 | 46 | 16385 | 23488 | 63449103 |
| Pancytopenia | 50.19 | 18.80 | 90 | 16341 | 96843 | 63375748 |
| Headache | 49.20 | 18.80 | 55 | 16376 | 633186 | 62839405 |
| Rheumatoid arthritis | 47.92 | 18.80 | 5 | 16426 | 253814 | 63218777 |
| Fungaemia | 46.60 | 18.80 | 19 | 16412 | 2384 | 63470207 |
| Aspartate aminotransferase increased | 45.69 | 18.80 | 83 | 16348 | 90194 | 63382397 |
| Cytomegalovirus test positive | 45.65 | 18.80 | 20 | 16411 | 2998 | 63469593 |
| Hypotension | 45.16 | 18.80 | 164 | 16267 | 272440 | 63200151 |
| Malaise | 43.51 | 18.80 | 27 | 16404 | 415927 | 63056664 |
| Eosinophilia | 42.56 | 18.80 | 40 | 16391 | 22716 | 63449875 |
| Clostridium difficile infection | 41.98 | 18.80 | 45 | 16386 | 29877 | 63442714 |
| Cholestatic liver injury | 41.77 | 18.80 | 18 | 16413 | 2592 | 63469999 |
| Dizziness | 40.85 | 18.80 | 31 | 16400 | 429894 | 63042697 |
| Systemic lupus erythematosus | 39.73 | 18.80 | 4 | 16427 | 208914 | 63263677 |
| Trichosporon infection | 38.93 | 18.80 | 10 | 16421 | 282 | 63472309 |
| Drug ineffective for unapproved indication | 38.86 | 18.80 | 46 | 16385 | 34017 | 63438574 |
| Renal impairment | 38.23 | 18.80 | 76 | 16355 | 88279 | 63384312 |
| Respiratory distress | 37.33 | 18.80 | 45 | 16386 | 33906 | 63438685 |
| Enterococcal infection | 37.31 | 18.80 | 24 | 16407 | 7824 | 63464767 |
| Renal failure | 37.02 | 18.80 | 89 | 16342 | 117563 | 63355028 |
| Mucormycosis | 36.97 | 18.80 | 17 | 16414 | 2854 | 63469737 |
| Swelling | 36.25 | 18.80 | 13 | 16418 | 275365 | 63197226 |
| Blood creatinine increased | 36.15 | 18.80 | 74 | 16357 | 87770 | 63384821 |
| Peripheral swelling | 35.96 | 18.80 | 12 | 16419 | 265930 | 63206661 |
| Therapeutic product effect decreased | 35.96 | 18.80 | 4 | 16427 | 193183 | 63279408 |
| Stenotrophomonas infection | 35.83 | 18.80 | 15 | 16416 | 2012 | 63470579 |
| Agranulocytosis | 35.61 | 18.80 | 38 | 16393 | 25096 | 63447495 |
| Nephropathy toxic | 35.51 | 18.80 | 25 | 16406 | 9454 | 63463137 |
| Bronchopulmonary aspergillosis | 35.22 | 18.80 | 24 | 16407 | 8611 | 63463980 |
| Weight decreased | 34.88 | 18.80 | 14 | 16417 | 276784 | 63195807 |
| Rash maculo-papular | 34.62 | 18.80 | 42 | 16389 | 31854 | 63440737 |
| Product dose omission issue | 34.55 | 18.80 | 9 | 16422 | 234304 | 63238287 |
| White blood cell count decreased | 34.27 | 18.80 | 96 | 16335 | 139008 | 63333583 |
| Alanine aminotransferase increased | 34.27 | 18.80 | 80 | 16351 | 103690 | 63368901 |
| Pseudomonas infection | 33.93 | 18.80 | 26 | 16405 | 11187 | 63461404 |
| Acute respiratory failure | 33.57 | 18.80 | 43 | 16388 | 34442 | 63438149 |
| Metabolic encephalopathy | 33.27 | 18.80 | 20 | 16411 | 5789 | 63466802 |
| Differentiation syndrome | 33.15 | 18.80 | 12 | 16419 | 1091 | 63471500 |
| Hepatic function abnormal | 32.58 | 18.80 | 44 | 16387 | 37098 | 63435493 |
| Antibiotic level above therapeutic | 31.89 | 18.80 | 9 | 16422 | 365 | 63472226 |
| Anaemia | 31.72 | 18.80 | 155 | 16276 | 293275 | 63179316 |
| Leukopenia | 31.67 | 18.80 | 65 | 16366 | 77225 | 63395366 |
| Nephritis allergic | 31.51 | 18.80 | 8 | 16423 | 215 | 63472376 |
| Sinusitis | 31.04 | 18.80 | 10 | 16421 | 226643 | 63245948 |
| Encephalitis Japanese B | 30.73 | 18.80 | 6 | 16425 | 45 | 63472546 |
| Toxic epidermal necrolysis | 30.20 | 18.80 | 35 | 16396 | 25299 | 63447292 |
| Hypertensive heart disease | 29.95 | 18.80 | 14 | 16417 | 2438 | 63470153 |
| Enterococcal bacteraemia | 29.89 | 18.80 | 12 | 16419 | 1447 | 63471144 |
| Pulmonary trichosporonosis | 29.56 | 18.80 | 6 | 16425 | 56 | 63472535 |
| Musculoskeletal stiffness | 29.38 | 18.80 | 6 | 16425 | 184612 | 63287979 |
| Toxic skin eruption | 28.71 | 18.80 | 25 | 16406 | 12860 | 63459731 |
| Confusional state | 28.56 | 18.80 | 129 | 16302 | 236251 | 63236340 |
| Eosinophilic pneumonia | 28.18 | 18.80 | 13 | 16418 | 2198 | 63470393 |
| Graft versus host disease | 28.07 | 18.80 | 19 | 16412 | 6744 | 63465847 |
| Acute myeloid leukaemia | 28.03 | 18.80 | 28 | 16403 | 17119 | 63455472 |
| Leukocytosis | 27.90 | 18.80 | 34 | 16397 | 25901 | 63446690 |
| Dysbiosis | 27.77 | 18.80 | 10 | 16421 | 896 | 63471695 |
| Staphylococcal infection | 27.61 | 18.80 | 43 | 16388 | 41213 | 63431378 |
| Hyperbilirubinaemia | 27.35 | 18.80 | 23 | 16408 | 11291 | 63461300 |
| Off label use | 26.74 | 18.80 | 279 | 16152 | 674183 | 62798408 |
| Pneumonia fungal | 26.72 | 18.80 | 17 | 16414 | 5438 | 63467153 |
| Product use issue | 26.42 | 18.80 | 12 | 16419 | 220508 | 63252083 |
| Weight increased | 25.78 | 18.80 | 18 | 16413 | 260774 | 63211817 |
| Hypoaesthesia | 25.73 | 18.80 | 6 | 16425 | 168387 | 63304204 |
| Disseminated intravascular coagulation | 25.58 | 18.80 | 28 | 16403 | 19023 | 63453568 |
| Acute graft versus host disease in skin | 25.42 | 18.80 | 14 | 16417 | 3438 | 63469153 |
| Hypersensitivity | 25.42 | 18.80 | 23 | 16408 | 292662 | 63179929 |
| Tumour lysis syndrome | 25.36 | 18.80 | 20 | 16411 | 8970 | 63463621 |
| Gait disturbance | 25.22 | 18.80 | 8 | 16423 | 183170 | 63289421 |
| Klebsiella bacteraemia | 24.99 | 18.80 | 11 | 16420 | 1667 | 63470924 |
| Tonsillitis bacterial | 24.96 | 18.80 | 6 | 16425 | 128 | 63472463 |
| Chemotherapeutic drug level increased | 24.65 | 18.80 | 6 | 16425 | 135 | 63472456 |
| Cholestasis | 24.50 | 18.80 | 34 | 16397 | 29400 | 63443191 |
| Aphasia | 24.36 | 18.80 | 36 | 16395 | 32964 | 63439627 |
| Neutropenic colitis | 24.04 | 18.80 | 13 | 16418 | 3082 | 63469509 |
| Candida infection | 23.97 | 18.80 | 33 | 16398 | 28318 | 63444273 |
| Pericarditis | 23.79 | 18.80 | 3 | 16428 | 131576 | 63341015 |
| Metabolic acidosis | 23.50 | 18.80 | 42 | 16389 | 45027 | 63427564 |
| Fall | 23.47 | 18.80 | 41 | 16390 | 392293 | 63080298 |
| Engraft failure | 23.22 | 18.80 | 7 | 16424 | 359 | 63472232 |
| Hyperoxaluria | 23.10 | 18.80 | 6 | 16425 | 177 | 63472414 |
| Stress cardiomyopathy | 22.41 | 18.80 | 19 | 16412 | 9431 | 63463160 |
| Neutrophilia | 22.25 | 18.80 | 14 | 16417 | 4392 | 63468199 |
| Eosinophilic pneumonia acute | 22.17 | 18.80 | 7 | 16424 | 419 | 63472172 |
| Cytomegalovirus viraemia | 21.39 | 18.80 | 15 | 16416 | 5634 | 63466957 |
| Pseudomembranous colitis | 21.23 | 18.80 | 12 | 16419 | 3100 | 63469491 |
| Muscle spasms | 21.17 | 18.80 | 7 | 16424 | 156143 | 63316448 |
| Blood bilirubin increased | 21.17 | 18.80 | 36 | 16395 | 37104 | 63435487 |
| Venoocclusive liver disease | 21.06 | 18.80 | 14 | 16417 | 4821 | 63467770 |
| Altered state of consciousness | 20.78 | 18.80 | 29 | 16402 | 25201 | 63447390 |
| Asthma | 20.60 | 18.80 | 4 | 16427 | 127557 | 63345034 |
| Thrombotic microangiopathy | 20.58 | 18.80 | 19 | 16412 | 10542 | 63462049 |
| Meningitis bacterial | 20.48 | 18.80 | 9 | 16422 | 1358 | 63471233 |
| Seizure | 20.41 | 18.80 | 78 | 16353 | 132556 | 63340035 |
| Ileus | 20.39 | 18.80 | 22 | 16409 | 14703 | 63457888 |
| Pulmonary haemorrhage | 20.31 | 18.80 | 16 | 16415 | 7165 | 63465426 |
| Enterococcal sepsis | 20.17 | 18.80 | 9 | 16422 | 1409 | 63471182 |
| Respiratory alkalosis | 20.02 | 18.80 | 11 | 16420 | 2690 | 63469901 |
| Pleural effusion | 19.76 | 18.80 | 61 | 16370 | 93149 | 63379442 |
| Small intestinal obstruction | 19.66 | 18.80 | 24 | 16407 | 18313 | 63454278 |
| Lower respiratory tract infection | 19.65 | 18.80 | 5 | 16426 | 132302 | 63340289 |
| Laryngeal inflammation | 19.57 | 18.80 | 5 | 16426 | 138 | 63472453 |
| Pain in extremity | 19.49 | 18.80 | 35 | 16396 | 331451 | 63141140 |
| Angiokeratoma | 19.33 | 18.80 | 5 | 16426 | 145 | 63472446 |
| Electrocardiogram T wave alternans | 19.28 | 18.80 | 4 | 16427 | 42 | 63472549 |
| Delirium | 18.95 | 18.80 | 41 | 16390 | 50500 | 63422091 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Encephalopathy | 248.14 | 16.07 | 191 | 21117 | 35128 | 34900495 |
| Acute kidney injury | 247.87 | 16.07 | 561 | 20747 | 304427 | 34631196 |
| Neurotoxicity | 192.78 | 16.07 | 126 | 21182 | 17884 | 34917739 |
| Cytokine release syndrome | 178.97 | 16.07 | 132 | 21176 | 22745 | 34912878 |
| Febrile neutropenia | 172.39 | 16.07 | 303 | 21005 | 136546 | 34799077 |
| Drug reaction with eosinophilia and systemic symptoms | 163.83 | 16.07 | 146 | 21162 | 32866 | 34902757 |
| Septic shock | 131.68 | 16.07 | 189 | 21119 | 71645 | 34863978 |
| Respiratory failure | 102.67 | 16.07 | 213 | 21095 | 108359 | 34827264 |
| Multiple organ dysfunction syndrome | 102.03 | 16.07 | 174 | 21134 | 76392 | 34859231 |
| Pyrexia | 89.49 | 16.07 | 420 | 20888 | 332593 | 34603030 |
| Fatigue | 87.03 | 16.07 | 60 | 21248 | 370593 | 34565030 |
| Hypoxia | 78.40 | 16.07 | 129 | 21179 | 54966 | 34880657 |
| Immune effector cell-associated neurotoxicity syndrome | 77.18 | 16.07 | 40 | 21268 | 3673 | 34931950 |
| Renal tubular necrosis | 77.04 | 16.07 | 69 | 21239 | 15611 | 34920012 |
| Pathogen resistance | 77.01 | 16.07 | 56 | 21252 | 9426 | 34926197 |
| Clostridium difficile colitis | 74.88 | 16.07 | 68 | 21240 | 15662 | 34919961 |
| Acute generalised exanthematous pustulosis | 73.91 | 16.07 | 48 | 21260 | 6728 | 34928895 |
| Sepsis | 73.73 | 16.07 | 246 | 21062 | 166315 | 34769308 |
| Mental status changes | 69.40 | 16.07 | 100 | 21208 | 37983 | 34897640 |
| Myoclonus | 68.81 | 16.07 | 63 | 21245 | 14662 | 34920961 |
| Tubulointerstitial nephritis | 68.66 | 16.07 | 74 | 21234 | 20950 | 34914673 |
| Neutrophil count decreased | 66.52 | 16.07 | 115 | 21193 | 50989 | 34884634 |
| Dizziness | 61.79 | 16.07 | 28 | 21280 | 218493 | 34717130 |
| Methaemoglobinaemia | 56.13 | 16.07 | 32 | 21276 | 3549 | 34932074 |
| Product dose omission issue | 54.68 | 16.07 | 5 | 21303 | 119706 | 34815917 |
| Enterococcal infection | 53.91 | 16.07 | 45 | 21263 | 9261 | 34926362 |
| Death | 49.29 | 16.07 | 106 | 21202 | 397943 | 34537680 |
| Neutropenia | 48.85 | 16.07 | 207 | 21101 | 156571 | 34779052 |
| Bacteraemia | 46.95 | 16.07 | 59 | 21249 | 19658 | 34915965 |
| Disseminated intravascular coagulation | 46.80 | 16.07 | 62 | 21246 | 21754 | 34913869 |
| Pseudomonas infection | 46.54 | 16.07 | 47 | 21261 | 12335 | 34923288 |
| Bronchopulmonary aspergillosis | 43.36 | 16.07 | 49 | 21259 | 14610 | 34921013 |
| Meningitis candida | 43.16 | 16.07 | 10 | 21298 | 71 | 34935552 |
| Brain herniation | 42.75 | 16.07 | 28 | 21280 | 3980 | 34931643 |
| Status epilepticus | 42.23 | 16.07 | 45 | 21263 | 12569 | 34923054 |
| Haemodialysis | 41.49 | 16.07 | 41 | 21267 | 10485 | 34925138 |
| Immune thrombocytopenia | 40.51 | 16.07 | 38 | 21270 | 9114 | 34926509 |
| Myocardial infarction | 40.10 | 16.07 | 12 | 21296 | 121073 | 34814550 |
| Septic embolus | 39.48 | 16.07 | 18 | 21290 | 1247 | 34934376 |
| Nephropathy toxic | 38.81 | 16.07 | 43 | 21265 | 12545 | 34923078 |
| Aspergillus infection | 38.03 | 16.07 | 42 | 21266 | 12212 | 34923411 |
| Platelet count decreased | 37.98 | 16.07 | 159 | 21149 | 119558 | 34816065 |
| Arthralgia | 37.84 | 16.07 | 29 | 21279 | 170012 | 34765611 |
| Drug resistance | 37.24 | 16.07 | 61 | 21247 | 25866 | 34909757 |
| Acute respiratory distress syndrome | 37.17 | 16.07 | 61 | 21247 | 25908 | 34909715 |
| Fall | 36.47 | 16.07 | 42 | 21266 | 202843 | 34732780 |
| Botulism | 35.74 | 16.07 | 10 | 21298 | 161 | 34935462 |
| Thrombocytopenia | 34.61 | 16.07 | 187 | 21121 | 156060 | 34779563 |
| Confusional state | 34.31 | 16.07 | 176 | 21132 | 143984 | 34791639 |
| Blood culture positive | 33.82 | 16.07 | 26 | 21282 | 4757 | 34930866 |
| White blood cell count decreased | 33.63 | 16.07 | 131 | 21177 | 95314 | 34840309 |
| Aspartate aminotransferase increased | 33.41 | 16.07 | 104 | 21204 | 67679 | 34867944 |
| Depression | 33.29 | 16.07 | 9 | 21299 | 97089 | 34838534 |
| Glomerulosclerosis | 32.95 | 16.07 | 14 | 21294 | 819 | 34934804 |
| Systemic candida | 32.53 | 16.07 | 23 | 21285 | 3703 | 34931920 |
| Clostridium difficile infection | 32.06 | 16.07 | 48 | 21260 | 18850 | 34916773 |
| Pain | 32.02 | 16.07 | 47 | 21261 | 204628 | 34730995 |
| Antibiotic level above therapeutic | 31.95 | 16.07 | 10 | 21298 | 241 | 34935382 |
| Drug ineffective for unapproved indication | 31.66 | 16.07 | 54 | 21254 | 23661 | 34911962 |
| Cholestasis | 31.64 | 16.07 | 58 | 21250 | 26890 | 34908733 |
| Eosinophilia | 30.23 | 16.07 | 56 | 21252 | 26166 | 34909457 |
| Insomnia | 29.81 | 16.07 | 13 | 21295 | 103894 | 34831729 |
| Toxic encephalopathy | 29.61 | 16.07 | 25 | 21283 | 5224 | 34930399 |
| Haemophagocytic lymphohistiocytosis | 29.58 | 16.07 | 38 | 21270 | 12935 | 34922688 |
| Klebsiella infection | 29.56 | 16.07 | 31 | 21277 | 8500 | 34927123 |
| Cytomegalovirus viraemia | 29.39 | 16.07 | 29 | 21279 | 7401 | 34928222 |
| Uraemic encephalopathy | 29.09 | 16.07 | 10 | 21298 | 326 | 34935297 |
| Weight decreased | 29.04 | 16.07 | 39 | 21269 | 176262 | 34759361 |
| Mucormycosis | 28.88 | 16.07 | 26 | 21282 | 5916 | 34929707 |
| Cytomegalovirus enterocolitis | 27.47 | 16.07 | 13 | 21295 | 981 | 34934642 |
| Candida infection | 27.24 | 16.07 | 43 | 21265 | 17672 | 34917951 |
| Toxic epidermal necrolysis | 27.21 | 16.07 | 48 | 21260 | 21598 | 34914025 |
| Gait disturbance | 27.17 | 16.07 | 9 | 21299 | 85131 | 34850492 |
| Burkholderia test positive | 27.11 | 16.07 | 13 | 21295 | 1010 | 34934613 |
| Blood pressure increased | 26.94 | 16.07 | 10 | 21298 | 88092 | 34847531 |
| Drug ineffective | 25.96 | 16.07 | 406 | 20902 | 456345 | 34479278 |
| Dyspnoea | 25.92 | 16.07 | 130 | 21178 | 376652 | 34558971 |
| Enterocolitis | 25.75 | 16.07 | 28 | 21280 | 7998 | 34927625 |
| Metabolic encephalopathy | 25.36 | 16.07 | 21 | 21287 | 4271 | 34931352 |
| Cytokine storm | 25.03 | 16.07 | 11 | 21297 | 699 | 34934924 |
| Anxiety | 24.71 | 16.07 | 15 | 21293 | 99413 | 34836210 |
| Off label use | 24.62 | 16.07 | 375 | 20933 | 419149 | 34516474 |
| Alanine aminotransferase increased | 24.57 | 16.07 | 106 | 21202 | 80709 | 34854914 |
| Disseminated mucormycosis | 24.47 | 16.07 | 10 | 21298 | 530 | 34935093 |
| Headache | 24.26 | 16.07 | 54 | 21254 | 200581 | 34735042 |
| Pleural effusion | 24.06 | 16.07 | 106 | 21202 | 81440 | 34854183 |
| Respiratory distress | 23.71 | 16.07 | 61 | 21247 | 35604 | 34900019 |
| Joint swelling | 23.69 | 16.07 | 4 | 21304 | 59886 | 34875737 |
| Feeling abnormal | 23.36 | 16.07 | 5 | 21303 | 63230 | 34872393 |
| Bacterial toxaemia | 23.32 | 16.07 | 7 | 21301 | 146 | 34935477 |
| Malaise | 23.31 | 16.07 | 49 | 21259 | 185776 | 34749847 |
| Asthenia | 22.89 | 16.07 | 75 | 21233 | 245176 | 34690447 |
| Peripheral swelling | 22.88 | 16.07 | 9 | 21299 | 76532 | 34859091 |
| Inappropriate schedule of product administration | 22.86 | 16.07 | 5 | 21303 | 62291 | 34873332 |
| Acute respiratory failure | 22.77 | 16.07 | 55 | 21253 | 30873 | 34904750 |
| Acute myeloid leukaemia recurrent | 22.75 | 16.07 | 15 | 21293 | 2155 | 34933468 |
| Choluria | 22.64 | 16.07 | 7 | 21301 | 162 | 34935461 |
| Rash morbilliform | 22.31 | 16.07 | 17 | 21291 | 3070 | 34932553 |
| Transaminases increased | 22.27 | 16.07 | 50 | 21258 | 26773 | 34908850 |
| Delirium | 22.13 | 16.07 | 68 | 21240 | 43923 | 34891700 |
| Renal failure | 21.68 | 16.07 | 145 | 21163 | 130412 | 34805211 |
| Trichosporon infection | 21.52 | 16.07 | 10 | 21298 | 724 | 34934899 |
| Blood creatinine increased | 21.21 | 16.07 | 114 | 21194 | 94862 | 34840761 |
| Hypersensitivity vasculitis | 21.14 | 16.07 | 17 | 21291 | 3318 | 34932305 |
| Acute myeloid leukaemia | 21.04 | 16.07 | 39 | 21269 | 18231 | 34917392 |
| Drug-induced liver injury | 20.94 | 16.07 | 51 | 21257 | 28781 | 34906842 |
| Fungal infection | 20.89 | 16.07 | 36 | 21272 | 15899 | 34919724 |
| Leukoerythroblastosis | 20.43 | 16.07 | 5 | 21303 | 46 | 34935577 |
| Cerebral aspergillosis | 20.33 | 16.07 | 12 | 21296 | 1420 | 34934203 |
| Kidney fibrosis | 20.02 | 16.07 | 14 | 21294 | 2214 | 34933409 |
| Corynebacterium infection | 19.84 | 16.07 | 9 | 21299 | 616 | 34935007 |
| Drug intolerance | 19.53 | 16.07 | 6 | 21302 | 59564 | 34876059 |
| Systemic mycosis | 19.29 | 16.07 | 12 | 21296 | 1561 | 34934062 |
| Aphasia | 18.95 | 16.07 | 41 | 21267 | 21413 | 34914210 |
| Musculoskeletal stiffness | 18.72 | 16.07 | 3 | 21305 | 46677 | 34888946 |
| Lactobacillus infection | 18.56 | 16.07 | 7 | 21301 | 299 | 34935324 |
| Pneumonia bacterial | 18.50 | 16.07 | 29 | 21279 | 11843 | 34923780 |
| Vanishing bile duct syndrome | 18.42 | 16.07 | 10 | 21298 | 1008 | 34934615 |
| Agranulocytosis | 18.22 | 16.07 | 43 | 21265 | 23778 | 34911845 |
| Acute lymphocytic leukaemia recurrent | 18.21 | 16.07 | 15 | 21293 | 3029 | 34932594 |
| Nasopharyngitis | 18.17 | 16.07 | 10 | 21298 | 69958 | 34865665 |
| Procalcitonin increased | 18.11 | 16.07 | 12 | 21296 | 1739 | 34933884 |
| Disseminated cryptococcosis | 18.08 | 16.07 | 11 | 21297 | 1375 | 34934248 |
| Sputum culture positive | 17.88 | 16.07 | 12 | 21296 | 1776 | 34933847 |
| Hypotension | 17.86 | 16.07 | 210 | 21098 | 221439 | 34714184 |
| Flavobacterium infection | 17.84 | 16.07 | 5 | 21303 | 81 | 34935542 |
| Pancytopenia | 17.83 | 16.07 | 109 | 21199 | 95048 | 34840575 |
| Differentiation syndrome | 17.71 | 16.07 | 11 | 21297 | 1427 | 34934196 |
| Organising pneumonia | 17.70 | 16.07 | 20 | 21288 | 5959 | 34929664 |
| Muscle spasms | 17.69 | 16.07 | 12 | 21296 | 74989 | 34860634 |
| Pneumonia | 17.48 | 16.07 | 314 | 20994 | 362313 | 34573310 |
| Enterococcal bacteraemia | 17.24 | 16.07 | 12 | 21296 | 1885 | 34933738 |
| Pulmonary haemorrhage | 17.23 | 16.07 | 26 | 21282 | 10278 | 34925345 |
| Unresponsive to stimuli | 17.15 | 16.07 | 46 | 21262 | 27523 | 34908100 |
| Eye infection fungal | 17.09 | 16.07 | 7 | 21301 | 373 | 34935250 |
| Pain in extremity | 17.02 | 16.07 | 32 | 21276 | 126481 | 34809142 |
| Retinal ischaemia | 16.97 | 16.07 | 7 | 21301 | 380 | 34935243 |
| Dialysis | 16.95 | 16.07 | 27 | 21281 | 11181 | 34924442 |
| Memory impairment | 16.89 | 16.07 | 3 | 21305 | 43315 | 34892308 |
| Enterobacter infection | 16.72 | 16.07 | 13 | 21295 | 2417 | 34933206 |
| Tumour lysis syndrome | 16.69 | 16.07 | 34 | 21274 | 17025 | 34918598 |
| Staphylococcal sepsis | 16.69 | 16.07 | 25 | 21283 | 9819 | 34925804 |
| Adenoviral haemorrhagic cystitis | 16.51 | 16.07 | 7 | 21301 | 407 | 34935216 |
| Drug eruption | 16.41 | 16.07 | 37 | 21271 | 19861 | 34915762 |
| Hepatosplenic candidiasis | 16.29 | 16.07 | 6 | 21302 | 240 | 34935383 |
| Nausea | 16.27 | 16.07 | 131 | 21177 | 339777 | 34595846 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Encephalopathy | 641.01 | 15.98 | 390 | 35219 | 67007 | 79641772 |
| Acute kidney injury | 540.85 | 15.98 | 887 | 34722 | 518517 | 79190262 |
| Neurotoxicity | 415.02 | 15.98 | 228 | 35381 | 32290 | 79676489 |
| Febrile neutropenia | 393.00 | 15.98 | 499 | 35110 | 230500 | 79478279 |
| Drug reaction with eosinophilia and systemic symptoms | 351.41 | 15.98 | 264 | 35345 | 63980 | 79644799 |
| Cytokine release syndrome | 336.01 | 15.98 | 206 | 35403 | 35792 | 79672987 |
| Septic shock | 238.65 | 15.98 | 284 | 35325 | 122517 | 79586262 |
| Multiple organ dysfunction syndrome | 213.98 | 15.98 | 266 | 35343 | 119980 | 79588799 |
| Status epilepticus | 210.19 | 15.98 | 134 | 35475 | 24907 | 79683872 |
| Myoclonus | 190.90 | 15.98 | 131 | 35478 | 27529 | 79681250 |
| Pyrexia | 185.39 | 15.98 | 693 | 34916 | 678016 | 79030763 |
| Sepsis | 182.95 | 15.98 | 384 | 35225 | 269044 | 79439735 |
| Respiratory failure | 180.36 | 15.98 | 304 | 35305 | 180607 | 79528172 |
| Mental status changes | 173.34 | 15.98 | 180 | 35429 | 66779 | 79642000 |
| Thrombocytopenia | 151.70 | 15.98 | 353 | 35256 | 264906 | 79443873 |
| Immune effector cell-associated neurotoxicity syndrome | 149.83 | 15.98 | 66 | 35543 | 5782 | 79702997 |
| Acute generalised exanthematous pustulosis | 146.45 | 15.98 | 93 | 35516 | 17161 | 79691618 |
| Tubulointerstitial nephritis | 145.09 | 15.98 | 127 | 35482 | 38108 | 79670671 |
| Fatigue | 144.97 | 15.98 | 122 | 35487 | 929605 | 78779174 |
| Renal tubular necrosis | 137.01 | 15.98 | 103 | 35506 | 24936 | 79683843 |
| Pain | 137.01 | 15.98 | 72 | 35537 | 703730 | 79005049 |
| Hypoxia | 129.75 | 15.98 | 193 | 35416 | 103050 | 79605729 |
| Arthralgia | 127.71 | 15.98 | 48 | 35561 | 571755 | 79137024 |
| Clostridium difficile colitis | 126.05 | 15.98 | 109 | 35500 | 32174 | 79676605 |
| Neutrophil count decreased | 124.36 | 15.98 | 180 | 35429 | 93779 | 79615000 |
| Neutropenia | 120.98 | 15.98 | 341 | 35268 | 287369 | 79421410 |
| Pathogen resistance | 118.48 | 15.98 | 76 | 35533 | 14266 | 79694513 |
| Dizziness | 109.73 | 15.98 | 49 | 35560 | 526392 | 79182387 |
| Platelet count decreased | 106.76 | 15.98 | 255 | 35354 | 194409 | 79514370 |
| Joint swelling | 104.70 | 15.98 | 6 | 35603 | 288640 | 79420139 |
| Drug resistance | 101.24 | 15.98 | 109 | 35500 | 42104 | 79666675 |
| Toxic encephalopathy | 100.43 | 15.98 | 63 | 35546 | 11377 | 79697402 |
| Bacteraemia | 89.90 | 15.98 | 91 | 35518 | 32733 | 79676046 |
| Headache | 88.60 | 15.98 | 97 | 35512 | 653675 | 79055104 |
| Enterococcal infection | 86.96 | 15.98 | 65 | 35544 | 15595 | 79693184 |
| Klebsiella infection | 84.52 | 15.98 | 64 | 35545 | 15656 | 79693123 |
| Drug intolerance | 81.01 | 15.98 | 11 | 35598 | 264108 | 79444671 |
| Product dose omission issue | 79.11 | 15.98 | 9 | 35600 | 247528 | 79461251 |
| Acute respiratory distress syndrome | 77.50 | 15.98 | 97 | 35512 | 43970 | 79664809 |
| Malaise | 73.99 | 15.98 | 66 | 35543 | 489803 | 79218976 |
| Rheumatoid arthritis | 73.58 | 15.98 | 5 | 35604 | 208465 | 79500314 |
| Nasopharyngitis | 72.36 | 15.98 | 13 | 35596 | 253868 | 79454911 |
| Pneumonia | 71.77 | 15.98 | 522 | 35087 | 659724 | 79049055 |
| Bronchopulmonary aspergillosis | 70.74 | 15.98 | 67 | 35542 | 22227 | 79686552 |
| Nephropathy toxic | 69.87 | 15.98 | 64 | 35545 | 20355 | 79688424 |
| Pseudomonas infection | 68.59 | 15.98 | 64 | 35545 | 20839 | 79687940 |
| Disseminated intravascular coagulation | 68.04 | 15.98 | 82 | 35527 | 35760 | 79673019 |
| Alopecia | 67.79 | 15.98 | 11 | 35598 | 231344 | 79477435 |
| Aspartate aminotransferase increased | 66.86 | 15.98 | 173 | 35436 | 138468 | 79570311 |
| Peripheral swelling | 66.46 | 15.98 | 19 | 35590 | 269598 | 79439181 |
| Eosinophilia | 66.07 | 15.98 | 91 | 35518 | 45254 | 79663525 |
| White blood cell count decreased | 64.70 | 15.98 | 208 | 35401 | 188080 | 79520699 |
| Clostridium difficile infection | 64.22 | 15.98 | 87 | 35522 | 42598 | 79666181 |
| Pancytopenia | 63.33 | 15.98 | 190 | 35419 | 165555 | 79543224 |
| Arthropathy | 63.23 | 15.98 | 4 | 35605 | 177107 | 79531672 |
| Abdominal discomfort | 63.04 | 15.98 | 17 | 35592 | 250710 | 79458069 |
| Mucormycosis | 62.92 | 15.98 | 42 | 35567 | 8427 | 79700352 |
| Fall | 60.98 | 15.98 | 77 | 35532 | 487552 | 79221227 |
| Therapeutic product effect decreased | 60.66 | 15.98 | 3 | 35606 | 163860 | 79544919 |
| Drug ineffective for unapproved indication | 60.37 | 15.98 | 93 | 35516 | 51145 | 79657634 |
| Renal failure | 59.34 | 15.98 | 211 | 35398 | 200757 | 79508022 |
| Blood creatinine increased | 57.59 | 15.98 | 176 | 35433 | 154881 | 79553898 |
| Methaemoglobinaemia | 57.49 | 15.98 | 34 | 35575 | 5523 | 79703256 |
| Weight decreased | 57.10 | 15.98 | 45 | 35564 | 355153 | 79353626 |
| Trichosporon infection | 56.34 | 15.98 | 20 | 35589 | 988 | 79707791 |
| Brain herniation | 55.41 | 15.98 | 37 | 35572 | 7426 | 79701353 |
| Confusional state | 55.14 | 15.98 | 284 | 35325 | 317713 | 79391066 |
| Cholestasis | 55.07 | 15.98 | 90 | 35519 | 52019 | 79656760 |
| Antibiotic level above therapeutic | 54.29 | 15.98 | 18 | 35591 | 722 | 79708057 |
| Metabolic encephalopathy | 53.10 | 15.98 | 39 | 35570 | 9108 | 79699671 |
| Haemodialysis | 52.75 | 15.98 | 52 | 35557 | 18116 | 79690663 |
| Toxic epidermal necrolysis | 51.23 | 15.98 | 80 | 35529 | 44501 | 79664278 |
| Acute respiratory failure | 50.10 | 15.98 | 93 | 35516 | 59448 | 79649331 |
| Shock | 49.84 | 15.98 | 78 | 35531 | 43470 | 79665309 |
| Musculoskeletal stiffness | 49.76 | 15.98 | 9 | 35600 | 174999 | 79533780 |
| Agranulocytosis | 49.26 | 15.98 | 79 | 35530 | 44951 | 79663828 |
| Septic embolus | 48.86 | 15.98 | 22 | 35587 | 2029 | 79706750 |
| Gait disturbance | 48.64 | 15.98 | 16 | 35593 | 207490 | 79501289 |
| Off label use | 48.33 | 15.98 | 617 | 34992 | 906598 | 78802181 |
| Alanine aminotransferase increased | 48.24 | 15.98 | 171 | 35438 | 162399 | 79546380 |
| Haemophagocytic lymphohistiocytosis | 48.21 | 15.98 | 54 | 35555 | 21783 | 79686996 |
| Hypotension | 48.21 | 15.98 | 349 | 35260 | 439968 | 79268811 |
| Fungaemia | 47.26 | 15.98 | 28 | 35581 | 4563 | 79704216 |
| Pleural effusion | 46.76 | 15.98 | 157 | 35452 | 145105 | 79563674 |
| Respiratory distress | 46.45 | 15.98 | 89 | 35520 | 58250 | 79650529 |
| Pain in extremity | 46.13 | 15.98 | 57 | 35552 | 364481 | 79344298 |
| Dyspnoea | 45.89 | 15.98 | 212 | 35397 | 856813 | 78851966 |
| Differentiation syndrome | 44.51 | 15.98 | 22 | 35587 | 2502 | 79706277 |
| Neutropenic colitis | 44.08 | 15.98 | 29 | 35580 | 5678 | 79703101 |
| Depression | 43.79 | 15.98 | 21 | 35588 | 216769 | 79492010 |
| Cytomegalovirus viraemia | 43.50 | 15.98 | 40 | 35569 | 12781 | 79695998 |
| Nausea | 43.25 | 15.98 | 251 | 35358 | 956945 | 78751834 |
| Candida infection | 43.11 | 15.98 | 68 | 35541 | 38146 | 79670633 |
| Cholestatic liver injury | 42.84 | 15.98 | 27 | 35582 | 4914 | 79703865 |
| Insomnia | 42.05 | 15.98 | 29 | 35580 | 245141 | 79463638 |
| Acute myeloid leukaemia | 42.04 | 15.98 | 60 | 35549 | 30825 | 79677954 |
| Blood pressure increased | 41.90 | 15.98 | 21 | 35588 | 211339 | 79497440 |
| Myocardial infarction | 41.76 | 15.98 | 15 | 35594 | 184114 | 79524665 |
| Weight increased | 41.07 | 15.98 | 38 | 35571 | 277348 | 79431431 |
| Tumour lysis syndrome | 40.98 | 15.98 | 52 | 35557 | 23887 | 79684892 |
| Meningitis candida | 40.53 | 15.98 | 10 | 35599 | 134 | 79708645 |
| Delirium | 40.16 | 15.98 | 105 | 35504 | 84522 | 79624257 |
| Hypoaesthesia | 40.02 | 15.98 | 15 | 35594 | 179337 | 79529442 |
| Systemic candida | 39.85 | 15.98 | 29 | 35580 | 6677 | 79702102 |
| Staphylococcal infection | 39.32 | 15.98 | 83 | 35526 | 58212 | 79650567 |
| Enterocolitis | 39.30 | 15.98 | 40 | 35569 | 14472 | 79694307 |
| Immune thrombocytopenia | 39.25 | 15.98 | 44 | 35565 | 17761 | 79691018 |
| Pulmonary haemorrhage | 38.83 | 15.98 | 40 | 35569 | 14677 | 79694102 |
| Blood bilirubin increased | 38.68 | 15.98 | 89 | 35520 | 66143 | 79642636 |
| Asthma | 38.29 | 15.98 | 7 | 35602 | 135088 | 79573691 |
| Aspergillus infection | 38.28 | 15.98 | 45 | 35564 | 19116 | 79689663 |
| Drug-induced liver injury | 36.59 | 15.98 | 87 | 35522 | 66030 | 79642749 |
| Renal impairment | 36.20 | 15.98 | 153 | 35456 | 157630 | 79551149 |
| Aphasia | 35.62 | 15.98 | 70 | 35539 | 46662 | 79662117 |
| Enterococcal bacteraemia | 34.99 | 15.98 | 20 | 35589 | 3048 | 79705731 |
| Arthritis | 34.69 | 15.98 | 5 | 35604 | 114875 | 79593904 |
| Discomfort | 34.56 | 15.98 | 7 | 35602 | 125610 | 79583169 |
| Feeling abnormal | 34.39 | 15.98 | 14 | 35595 | 159185 | 79549594 |
| Pneumonia fungal | 34.25 | 15.98 | 33 | 35576 | 11177 | 79697602 |
| Lower respiratory tract infection | 33.93 | 15.98 | 8 | 35601 | 129212 | 79579567 |
| Sinusitis | 33.68 | 15.98 | 23 | 35586 | 195478 | 79513301 |
| Muscle spasms | 33.68 | 15.98 | 18 | 35591 | 174712 | 79534067 |
| Swelling | 32.89 | 15.98 | 29 | 35580 | 216682 | 79492097 |
| Systemic lupus erythematosus | 32.82 | 15.98 | 7 | 35602 | 121142 | 79587637 |
| Mixed liver injury | 32.47 | 15.98 | 27 | 35582 | 7551 | 79701228 |
| Injection site pain | 32.25 | 15.98 | 9 | 35600 | 129829 | 79578950 |
| Drug level increased | 32.19 | 15.98 | 61 | 35548 | 39590 | 79669189 |
| Blood culture positive | 31.96 | 15.98 | 28 | 35581 | 8401 | 79700378 |
| Liver abscess | 31.12 | 15.98 | 24 | 35585 | 6030 | 79702749 |
| Pulmonary trichosporonosis | 31.01 | 15.98 | 7 | 35602 | 62 | 79708717 |
| Hepatic function abnormal | 30.97 | 15.98 | 87 | 35522 | 73020 | 79635759 |
| Cytomegalovirus enterocolitis | 30.90 | 15.98 | 15 | 35594 | 1640 | 79707139 |
| Rash morbilliform | 30.78 | 15.98 | 24 | 35585 | 6126 | 79702653 |
| Botulism | 30.66 | 15.98 | 10 | 35599 | 381 | 79708398 |
| Leukocytosis | 30.62 | 15.98 | 63 | 35546 | 43392 | 79665387 |
| Balance disorder | 30.56 | 15.98 | 4 | 35605 | 98853 | 79609926 |
| Anxiety | 30.23 | 15.98 | 40 | 35569 | 248472 | 79460307 |
| Rash maculo-papular | 30.18 | 15.98 | 73 | 35536 | 56005 | 79652774 |
| Paraesthesia | 30.03 | 15.98 | 21 | 35588 | 176302 | 79532477 |
| Leukopenia | 29.90 | 15.98 | 117 | 35492 | 116396 | 79592383 |
| Glomerulosclerosis | 29.83 | 15.98 | 13 | 35596 | 1109 | 79707670 |
| Cytomegalovirus test positive | 29.32 | 15.98 | 23 | 35586 | 5924 | 79702855 |
| Enterococcal sepsis | 29.04 | 15.98 | 17 | 35592 | 2709 | 79706070 |
| Uraemic encephalopathy | 28.68 | 15.98 | 11 | 35598 | 676 | 79708103 |
| Back pain | 28.56 | 15.98 | 58 | 35551 | 304122 | 79404657 |
| Pneumonia bacterial | 28.46 | 15.98 | 39 | 35570 | 19292 | 79689487 |
| Gastrooesophageal reflux disease | 28.28 | 15.98 | 6 | 35603 | 104240 | 79604539 |
| Contusion | 27.69 | 15.98 | 16 | 35593 | 148760 | 79560019 |
| Drug ineffective | 27.14 | 15.98 | 652 | 34957 | 1080261 | 78628518 |
| Engraftment syndrome | 27.00 | 15.98 | 13 | 35596 | 1396 | 79707383 |
| Blood cholesterol increased | 26.83 | 15.98 | 3 | 35606 | 83717 | 79625062 |
| Graft versus host disease | 26.29 | 15.98 | 33 | 35576 | 14993 | 79693786 |
| Dry mouth | 26.18 | 15.98 | 4 | 35605 | 88015 | 79620764 |
| Dyspepsia | 26.13 | 15.98 | 8 | 35601 | 108679 | 79600100 |
| Venoocclusive liver disease | 25.79 | 15.98 | 29 | 35580 | 11742 | 79697037 |
| Drug eruption | 25.60 | 15.98 | 59 | 35550 | 43876 | 79664903 |
| Chest pain | 25.51 | 15.98 | 55 | 35554 | 282249 | 79426530 |
| Asthenia | 25.31 | 15.98 | 130 | 35479 | 511559 | 79197220 |
| Cardiac arrest | 25.26 | 15.98 | 147 | 35462 | 171949 | 79536830 |
| Abdominal pain upper | 25.25 | 15.98 | 38 | 35571 | 223781 | 79484998 |
| Encephalitis Japanese B | 25.24 | 15.98 | 6 | 35603 | 68 | 79708711 |
| Unresponsive to stimuli | 25.22 | 15.98 | 68 | 35541 | 55720 | 79653059 |
| Bacterial toxaemia | 25.04 | 15.98 | 7 | 35602 | 156 | 79708623 |
| Procalcitonin increased | 25.00 | 15.98 | 16 | 35593 | 2990 | 79705789 |
| Nephritis allergic | 24.56 | 15.98 | 10 | 35599 | 720 | 79708059 |
| Activated partial thromboplastin time prolonged | 24.50 | 15.98 | 31 | 35578 | 14197 | 79694582 |
| Pericarditis | 24.48 | 15.98 | 8 | 35601 | 104228 | 79604551 |
| Disseminated mucormycosis | 24.33 | 15.98 | 10 | 35599 | 738 | 79708041 |
| Systemic mycosis | 24.20 | 15.98 | 15 | 35594 | 2651 | 79706128 |
| Loss of personal independence in daily activities | 23.87 | 15.98 | 8 | 35601 | 102572 | 79606207 |
| Meningitis bacterial | 23.86 | 15.98 | 15 | 35594 | 2717 | 79706062 |
| Memory impairment | 23.84 | 15.98 | 10 | 35599 | 111724 | 79597055 |
| Disseminated cryptococcosis | 23.76 | 15.98 | 13 | 35596 | 1821 | 79706958 |
| Osteoarthritis | 23.73 | 15.98 | 5 | 35604 | 87304 | 79621475 |
| Blood urea increased | 23.61 | 15.98 | 61 | 35548 | 48729 | 79660050 |
| Small intestinal obstruction | 23.44 | 15.98 | 43 | 35566 | 27229 | 79681550 |
| Transaminases increased | 23.32 | 15.98 | 63 | 35546 | 51680 | 79657099 |
| Enterobacter infection | 23.26 | 15.98 | 18 | 35591 | 4544 | 79704235 |
| Burkholderia test positive | 23.12 | 15.98 | 9 | 35600 | 576 | 79708203 |
| Hypersensitivity | 22.95 | 15.98 | 52 | 35557 | 262187 | 79446592 |
| Intentional product misuse | 22.89 | 15.98 | 7 | 35602 | 95158 | 79613621 |
| Serum ferritin increased | 22.85 | 15.98 | 25 | 35584 | 9822 | 79698957 |
| Hyperbilirubinaemia | 22.79 | 15.98 | 40 | 35569 | 24478 | 79684301 |
| Pseudomembranous colitis | 22.72 | 15.98 | 19 | 35590 | 5355 | 79703424 |
| Acute lymphocytic leukaemia recurrent | 22.70 | 15.98 | 18 | 35591 | 4706 | 79704073 |
| Inappropriate schedule of product administration | 22.64 | 15.98 | 16 | 35593 | 133612 | 79575167 |
| Device related infection | 22.17 | 15.98 | 48 | 35561 | 34246 | 79674533 |
| Lung infiltration | 22.10 | 15.98 | 38 | 35571 | 22874 | 79685905 |
| Clostridial infection | 21.70 | 15.98 | 19 | 35590 | 5695 | 79703084 |
| Corynebacterium infection | 21.64 | 15.98 | 11 | 35598 | 1327 | 79707452 |
| Chest discomfort | 21.51 | 15.98 | 18 | 35591 | 138026 | 79570753 |
| Vanishing bile duct syndrome | 21.38 | 15.98 | 12 | 35597 | 1766 | 79707013 |
| Systemic inflammatory response syndrome | 21.38 | 15.98 | 26 | 35583 | 11439 | 79697340 |
| Escherichia bacteraemia | 21.35 | 15.98 | 20 | 35589 | 6542 | 79702237 |
| Cerebral aspergillosis | 21.27 | 15.98 | 12 | 35597 | 1784 | 79706995 |
| Cytokine storm | 21.11 | 15.98 | 10 | 35599 | 1036 | 79707743 |
| Acidosis | 20.69 | 15.98 | 34 | 35575 | 19728 | 79689051 |
| Eosinophilic pneumonia acute | 20.65 | 15.98 | 10 | 35599 | 1088 | 79707691 |
| COVID-19 pneumonia | 20.53 | 15.98 | 42 | 35567 | 28807 | 79679972 |
| Device related sepsis | 20.26 | 15.98 | 19 | 35590 | 6221 | 79702558 |
| Tonsillitis bacterial | 20.16 | 15.98 | 6 | 35603 | 168 | 79708611 |
| Klebsiella bacteraemia | 20.15 | 15.98 | 14 | 35595 | 2996 | 79705783 |
| Product use in unapproved indication | 20.05 | 15.98 | 185 | 35424 | 250174 | 79458605 |
| Pulseless electrical activity | 19.99 | 15.98 | 28 | 35581 | 14132 | 79694647 |
| Respiratory alkalosis | 19.81 | 15.98 | 16 | 35593 | 4295 | 79704484 |
| Heparin-induced thrombocytopenia | 19.77 | 15.98 | 23 | 35586 | 9659 | 79699120 |
| Mediastinitis | 19.73 | 15.98 | 9 | 35600 | 855 | 79707924 |
| Staphylococcus test positive | 19.65 | 15.98 | 19 | 35590 | 6462 | 79702317 |
| Dialysis | 19.65 | 15.98 | 32 | 35577 | 18430 | 79690349 |
| Chemotherapeutic drug level increased | 19.64 | 15.98 | 7 | 35602 | 350 | 79708429 |
| Stenotrophomonas infection | 19.48 | 15.98 | 15 | 35594 | 3758 | 79705021 |
| Vomiting | 19.38 | 15.98 | 197 | 35412 | 665631 | 79043148 |
| Hypervolaemia | 19.26 | 15.98 | 52 | 35557 | 42638 | 79666141 |
| Therapeutic product effect incomplete | 19.12 | 15.98 | 21 | 35588 | 141624 | 79567155 |
| Organising pneumonia | 19.10 | 15.98 | 24 | 35585 | 10915 | 79697864 |
| Laryngeal inflammation | 19.02 | 15.98 | 6 | 35603 | 205 | 79708574 |
| Product contamination microbial | 18.95 | 15.98 | 9 | 35600 | 937 | 79707842 |
| Choluria | 18.76 | 15.98 | 7 | 35602 | 399 | 79708380 |
| Vertigo | 18.69 | 15.98 | 4 | 35605 | 69078 | 79639701 |
| Vascular device infection | 18.67 | 15.98 | 23 | 35586 | 10253 | 79698526 |
| Tachypnoea | 18.62 | 15.98 | 43 | 35566 | 32020 | 79676759 |
| Flavobacterium infection | 18.49 | 15.98 | 5 | 35604 | 98 | 79708681 |
| Coagulopathy | 18.45 | 15.98 | 46 | 35563 | 35960 | 79672819 |
| Injection site erythema | 18.36 | 15.98 | 6 | 35603 | 78191 | 79630588 |
| Hypertensive heart disease | 18.05 | 15.98 | 15 | 35594 | 4191 | 79704588 |
| Blastomycosis | 18.05 | 15.98 | 8 | 35601 | 711 | 79708068 |
| Palpitations | 17.96 | 15.98 | 18 | 35591 | 126592 | 79582187 |
| Adverse drug reaction | 17.64 | 15.98 | 4 | 35605 | 66388 | 79642391 |
| Cerebral haemorrhage | 17.37 | 15.98 | 61 | 35548 | 57612 | 79651167 |
| Pulmonary mucormycosis | 17.18 | 15.98 | 9 | 35600 | 1156 | 79707623 |
| Pneumonitis | 17.16 | 15.98 | 63 | 35546 | 60797 | 79647982 |
| Flushing | 17.14 | 15.98 | 9 | 35600 | 88259 | 79620520 |
| Blood lactate dehydrogenase increased | 16.96 | 15.98 | 47 | 35562 | 39123 | 79669656 |
| Eye infection fungal | 16.96 | 15.98 | 7 | 35602 | 522 | 79708257 |
| Impaired healing | 16.93 | 15.98 | 9 | 35600 | 87646 | 79621133 |
| Anaemia | 16.60 | 15.98 | 285 | 35324 | 444730 | 79264049 |
| Acute myeloid leukaemia recurrent | 16.49 | 15.98 | 13 | 35596 | 3370 | 79705409 |
| Product use issue | 16.47 | 15.98 | 44 | 35565 | 209778 | 79499001 |
| Liver disorder | 16.42 | 15.98 | 70 | 35539 | 72347 | 79636432 |
| Hypoalbuminaemia | 16.35 | 15.98 | 32 | 35577 | 21265 | 79687514 |
| Vision blurred | 16.26 | 15.98 | 14 | 35595 | 105884 | 79602895 |
| Hepatosplenic candidiasis | 16.25 | 15.98 | 7 | 35602 | 581 | 79708198 |
| Hypercapnia | 16.23 | 15.98 | 20 | 35589 | 8915 | 79699864 |
| Lymphatic disorder | 16.21 | 15.98 | 6 | 35603 | 334 | 79708445 |
| Posterior reversible encephalopathy syndrome | 16.10 | 15.98 | 36 | 35573 | 26245 | 79682534 |
| Arteritis coronary | 16.05 | 15.98 | 4 | 35605 | 56 | 79708723 |
| Rectal haemorrhage | 16.00 | 15.98 | 7 | 35602 | 76293 | 79632486 |
| Kidney fibrosis | 15.99 | 15.98 | 13 | 35596 | 3522 | 79705257 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Fourth-generation cephalosporins |
| ATC | J01RA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
| FDA CS | M0003827 | Cephalosporins |
| FDA EPC | N0000175488 | Cephalosporin Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Pneumonia due to Pseudomonas | indication | 41381004 | |
| Bacterial pneumonia | indication | 53084003 | DOID:874 |
| Klebsiella cystitis | indication | 60867007 | |
| Infectious disease of abdomen | indication | 128070006 | |
| Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
| Bacterial peritonitis | indication | 197171003 | |
| Pneumococcal pneumonia | indication | 233607000 | |
| Escherichia coli urinary tract infection | indication | 301011002 | |
| Proteus urinary tract infection | indication | 301012009 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Bacterial urinary infection | indication | 312124009 | |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
| Complicated Proteus UTI | indication | ||
| E. Coli Pyelonephritis | indication | ||
| Complicated Urinary Tract Infections | indication | ||
| Complicated Bacteroides Peritonitis | indication | ||
| Complicated Streptococcus Peritonitis | indication | ||
| Klebsiella Pyelonephritis | indication | ||
| Complicated E. Coli Peritonitis | indication | ||
| Enterobacter Pneumonia | indication | ||
| Complicated Klebsiella Peritonitis | indication | ||
| Proteus Pyelonephritis | indication | ||
| Myoclonus | contraindication | 17450006 | |
| Colitis | contraindication | 64226004 | DOID:0060180 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Factor II deficiency | contraindication | 73975000 | |
| Disorder of brain | contraindication | 81308009 | DOID:936 |
| Seizure disorder | contraindication | 128613002 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.32 | acidic |
| pKa2 | 13.31 | acidic |
| pKa3 | 3.1 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4024049 | VUID |
| N0000022054 | NUI |
| D01157 | KEGG_DRUG |
| 123171-59-5 | SECONDARY_CAS_RN |
| 20481 | RXNORM |
| C0055003 | UMLSCUI |
| CHEBI:478164 | CHEBI |
| 9WT | PDB_CHEM_ID |
| CHEMBL186 | ChEMBL_ID |
| CHEMBL1200962 | ChEMBL_ID |
| D000077723 | MESH_DESCRIPTOR_UI |
| DB01413 | DRUGBANK_ID |
| 10772 | IUPHAR_LIGAND_ID |
| 6092 | INN_ID |
| 807PW4VQE3 | UNII |
| 5479537 | PUBCHEM_CID |
| 116681 | MMSL |
| 4373 | MMSL |
| d03882 | MMSL |
| 370370003 | SNOMEDCT_US |
| 370371004 | SNOMEDCT_US |
| 96048006 | SNOMEDCT_US |
| 4020908 | VANDF |
| 4024049 | VANDF |
| 004974 | NDDF |
| 004975 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3222 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3223 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-130 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-131 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-240 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-241 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |