Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 535 | 88040-23-7 |
Dose | Unit | Route |
---|---|---|
4 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 85 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.28 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.78 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 18, 1996 | FDA | HOSPIRA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 369.76 | 18.17 | 183 | 14009 | 33528 | 50557404 |
Acute kidney injury | 296.41 | 18.17 | 341 | 13851 | 227717 | 50363215 |
Febrile neutropenia | 262.88 | 18.17 | 218 | 13974 | 97449 | 50493483 |
Neurotoxicity | 188.57 | 18.17 | 89 | 14103 | 14651 | 50576281 |
Status epilepticus | 177.83 | 18.17 | 83 | 14109 | 13323 | 50577609 |
Sepsis | 141.42 | 18.17 | 180 | 14012 | 132745 | 50458187 |
Myoclonus | 136.42 | 18.17 | 71 | 14121 | 14399 | 50576533 |
Drug reaction with eosinophilia and systemic symptoms | 136.37 | 18.17 | 90 | 14102 | 28334 | 50562598 |
Cytokine release syndrome | 131.93 | 18.17 | 59 | 14133 | 8575 | 50582357 |
Pyrexia | 130.03 | 18.17 | 311 | 13881 | 379892 | 50211040 |
Multiple organ dysfunction syndrome | 120.10 | 18.17 | 105 | 14087 | 50232 | 50540700 |
Septic shock | 99.33 | 18.17 | 100 | 14092 | 57075 | 50533857 |
Thrombocytopenia | 98.28 | 18.17 | 148 | 14044 | 127525 | 50463407 |
Tubulointerstitial nephritis | 95.13 | 18.17 | 57 | 14135 | 15154 | 50575778 |
Toxic encephalopathy | 88.47 | 18.17 | 39 | 14153 | 5476 | 50585456 |
Mental status changes | 87.17 | 18.17 | 76 | 14116 | 36196 | 50554736 |
Respiratory failure | 85.27 | 18.17 | 116 | 14076 | 91065 | 50499867 |
Pain | 84.03 | 18.17 | 29 | 14163 | 578874 | 50012058 |
Clostridium difficile colitis | 68.12 | 18.17 | 49 | 14143 | 17693 | 50573239 |
Pneumonia | 66.79 | 18.17 | 245 | 13947 | 378156 | 50212776 |
Arthralgia | 65.28 | 18.17 | 21 | 14171 | 438681 | 50152251 |
Klebsiella infection | 64.09 | 18.17 | 34 | 14158 | 7160 | 50583772 |
Neutrophil count decreased | 63.07 | 18.17 | 71 | 14121 | 45955 | 50544977 |
Fatigue | 60.41 | 18.17 | 66 | 14126 | 707535 | 49883397 |
Platelet count decreased | 60.00 | 18.17 | 104 | 14088 | 100622 | 50490310 |
Drug resistance | 58.57 | 18.17 | 46 | 14146 | 18943 | 50571989 |
Renal tubular necrosis | 58.17 | 18.17 | 36 | 14156 | 10132 | 50580800 |
Pathogen resistance | 56.73 | 18.17 | 29 | 14163 | 5660 | 50585272 |
Neutropenia | 55.70 | 18.17 | 126 | 14066 | 147839 | 50443093 |
Alopecia | 53.50 | 18.17 | 4 | 14188 | 245043 | 50345889 |
Hypoxia | 52.29 | 18.17 | 68 | 14124 | 51055 | 50539877 |
Acute generalised exanthematous pustulosis | 49.50 | 18.17 | 31 | 14161 | 8907 | 50582025 |
Mixed liver injury | 47.71 | 18.17 | 22 | 14170 | 3429 | 50587503 |
Abdominal discomfort | 47.27 | 18.17 | 5 | 14187 | 231636 | 50359296 |
Cytomegalovirus test positive | 47.03 | 18.17 | 20 | 14172 | 2572 | 50588360 |
Drug intolerance | 46.64 | 18.17 | 4 | 14188 | 219100 | 50371832 |
Headache | 44.52 | 18.17 | 46 | 14146 | 506489 | 50084443 |
Immune effector cell-associated neurotoxicity syndrome | 42.93 | 18.17 | 15 | 14177 | 1135 | 50589797 |
Nasopharyngitis | 42.52 | 18.17 | 3 | 14189 | 192924 | 50398008 |
Fungaemia | 41.47 | 18.17 | 17 | 14175 | 1995 | 50588937 |
Bacteraemia | 40.32 | 18.17 | 33 | 14159 | 14400 | 50576532 |
Rheumatoid arthritis | 39.75 | 18.17 | 5 | 14187 | 202545 | 50388387 |
Aspartate aminotransferase increased | 39.39 | 18.17 | 75 | 14117 | 77923 | 50513009 |
Malaise | 38.87 | 18.17 | 23 | 14169 | 335509 | 50255423 |
Acute respiratory distress syndrome | 38.62 | 18.17 | 38 | 14154 | 21061 | 50569871 |
Clostridium difficile infection | 37.87 | 18.17 | 41 | 14151 | 25398 | 50565534 |
Nephropathy toxic | 37.45 | 18.17 | 25 | 14167 | 8004 | 50582928 |
Renal impairment | 36.06 | 18.17 | 71 | 14121 | 75590 | 50515342 |
Confusional state | 35.75 | 18.17 | 124 | 14068 | 185804 | 50405128 |
Pancytopenia | 35.49 | 18.17 | 75 | 14117 | 83955 | 50506977 |
Trichosporon infection | 34.77 | 18.17 | 9 | 14183 | 241 | 50590691 |
Hypotension | 34.52 | 18.17 | 144 | 14048 | 235325 | 50355607 |
Antibiotic level above therapeutic | 34.42 | 18.17 | 9 | 14183 | 251 | 50590681 |
Respiratory distress | 33.44 | 18.17 | 42 | 14150 | 30447 | 50560485 |
Nephritis allergic | 33.42 | 18.17 | 8 | 14184 | 154 | 50590778 |
Dizziness | 33.25 | 18.17 | 29 | 14163 | 346340 | 50244592 |
Shock | 32 | 18.17 | 34 | 14158 | 20616 | 50570316 |
Renal failure | 31.73 | 18.17 | 83 | 14109 | 106550 | 50484382 |
Toxic epidermal necrolysis | 31.54 | 18.17 | 34 | 14158 | 20958 | 50569974 |
Metabolic encephalopathy | 31.51 | 18.17 | 19 | 14173 | 5102 | 50585830 |
Hepatic function abnormal | 31.14 | 18.17 | 42 | 14150 | 32639 | 50558293 |
Enterococcal infection | 31.03 | 18.17 | 21 | 14171 | 6877 | 50584055 |
White blood cell count decreased | 30.88 | 18.17 | 87 | 14105 | 116635 | 50474297 |
Enterococcal bacteraemia | 30.68 | 18.17 | 12 | 14180 | 1246 | 50589686 |
Product dose omission issue | 30.65 | 18.17 | 7 | 14185 | 183831 | 50407101 |
Differentiation syndrome | 30.39 | 18.17 | 11 | 14181 | 922 | 50590010 |
Peripheral swelling | 30.30 | 18.17 | 10 | 14182 | 205926 | 50385006 |
Dysbiosis | 30.08 | 18.17 | 10 | 14182 | 650 | 50590282 |
Toxic skin eruption | 29.92 | 18.17 | 25 | 14167 | 11226 | 50579706 |
Hypertensive heart disease | 29.91 | 18.17 | 14 | 14178 | 2256 | 50588676 |
Alanine aminotransferase increased | 29.66 | 18.17 | 72 | 14120 | 88287 | 50502645 |
Pseudomonas infection | 29.41 | 18.17 | 23 | 14169 | 9407 | 50581525 |
Anaemia | 29.22 | 18.17 | 144 | 14048 | 252312 | 50338620 |
Bronchopulmonary aspergillosis | 29.21 | 18.17 | 21 | 14171 | 7571 | 50583361 |
Weight decreased | 28.81 | 18.17 | 13 | 14179 | 221232 | 50369700 |
Blood creatinine increased | 28.77 | 18.17 | 65 | 14127 | 76095 | 50514837 |
Mucormycosis | 28.72 | 18.17 | 14 | 14178 | 2469 | 50588463 |
Leukocytosis | 27.84 | 18.17 | 33 | 14159 | 22546 | 50568386 |
Therapeutic product effect decreased | 27.57 | 18.17 | 3 | 14189 | 136047 | 50454885 |
Sinusitis | 27.44 | 18.17 | 7 | 14185 | 170551 | 50420381 |
Acute respiratory failure | 27.44 | 18.17 | 37 | 14155 | 28745 | 50562187 |
Klebsiella bacteraemia | 27.03 | 18.17 | 11 | 14181 | 1266 | 50589666 |
Systemic lupus erythematosus | 26.33 | 18.17 | 4 | 14188 | 140618 | 50450314 |
Acute graft versus host disease in skin | 26.13 | 18.17 | 14 | 14178 | 3004 | 50587928 |
Eosinophilia | 25.92 | 18.17 | 29 | 14163 | 18623 | 50572309 |
Graft versus host disease | 25.91 | 18.17 | 18 | 14174 | 6148 | 50584784 |
Eosinophilic pneumonia | 25.89 | 18.17 | 12 | 14180 | 1892 | 50589040 |
Swelling | 25.85 | 18.17 | 12 | 14180 | 200860 | 50390072 |
Cholestatic liver injury | 25.20 | 18.17 | 12 | 14180 | 2009 | 50588923 |
Rash maculo-papular | 25.02 | 18.17 | 34 | 14158 | 26607 | 50564325 |
Hyperoxaluria | 24.57 | 18.17 | 6 | 14186 | 126 | 50590806 |
Agranulocytosis | 24.27 | 18.17 | 30 | 14162 | 21391 | 50569541 |
Stenotrophomonas infection | 24.20 | 18.17 | 11 | 14181 | 1658 | 50589274 |
Chemotherapeutic drug level increased | 24.17 | 18.17 | 6 | 14186 | 135 | 50590797 |
Leukopenia | 23.70 | 18.17 | 56 | 14136 | 67472 | 50523460 |
Acute myeloid leukaemia | 23.68 | 18.17 | 25 | 14167 | 15049 | 50575883 |
Aphasia | 23.25 | 18.17 | 34 | 14158 | 28460 | 50562472 |
Hypersensitivity | 23.17 | 18.17 | 16 | 14176 | 215145 | 50375787 |
Neutropenic colitis | 23.17 | 18.17 | 12 | 14180 | 2405 | 50588527 |
Engraft failure | 22.97 | 18.17 | 7 | 14185 | 343 | 50590589 |
Hyperbilirubinaemia | 22.86 | 18.17 | 20 | 14172 | 9550 | 50581382 |
Cytomegalovirus viraemia | 22.78 | 18.17 | 15 | 14177 | 4694 | 50586238 |
Gait disturbance | 22.56 | 18.17 | 7 | 14185 | 149998 | 50440934 |
Cholestasis | 21.73 | 18.17 | 31 | 14161 | 25370 | 50565562 |
Pseudomembranous colitis | 21.57 | 18.17 | 12 | 14180 | 2773 | 50588159 |
Disseminated intravascular coagulation | 21.05 | 18.17 | 25 | 14167 | 17110 | 50573822 |
Hypoaesthesia | 20.90 | 18.17 | 5 | 14187 | 127252 | 50463680 |
Ileus | 20.88 | 18.17 | 22 | 14170 | 13207 | 50577725 |
Fall | 20.76 | 18.17 | 39 | 14153 | 334893 | 50256039 |
Enterococcal sepsis | 20.39 | 18.17 | 9 | 14183 | 1266 | 50589666 |
Encephalitis Japanese B | 20.29 | 18.17 | 4 | 14188 | 29 | 50590903 |
Respiratory alkalosis | 19.91 | 18.17 | 11 | 14181 | 2508 | 50588424 |
Tonsillitis bacterial | 19.84 | 18.17 | 5 | 14187 | 120 | 50590812 |
Laryngeal inflammation | 19.38 | 18.17 | 5 | 14187 | 132 | 50590800 |
Musculoskeletal stiffness | 19.31 | 18.17 | 6 | 14186 | 128475 | 50462457 |
Angiokeratoma | 19.24 | 18.17 | 5 | 14187 | 136 | 50590796 |
Weight increased | 19.22 | 18.17 | 17 | 14175 | 201874 | 50389058 |
Electrocardiogram T wave alternans | 18.96 | 18.17 | 4 | 14188 | 42 | 50590890 |
Staphylococcal infection | 18.90 | 18.17 | 35 | 14157 | 35581 | 50555351 |
Systemic candida | 18.86 | 18.17 | 11 | 14181 | 2779 | 50588153 |
Lymphatic disorder | 18.69 | 18.17 | 6 | 14186 | 349 | 50590583 |
Activated partial thromboplastin time prolonged | 18.64 | 18.17 | 15 | 14177 | 6387 | 50584545 |
Muscle spasms | 18.62 | 18.17 | 6 | 14186 | 125547 | 50465385 |
Mucosal inflammation | 18.31 | 18.17 | 37 | 14155 | 40105 | 50550827 |
Thrombotic microangiopathy | 18.30 | 18.17 | 17 | 14175 | 8774 | 50582158 |
Subdiaphragmatic abscess | 18.25 | 18.17 | 4 | 14188 | 51 | 50590881 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 230.30 | 16.18 | 176 | 18529 | 30867 | 29524955 |
Acute kidney injury | 198.19 | 16.18 | 483 | 18222 | 264784 | 29291038 |
Febrile neutropenia | 165.45 | 16.18 | 272 | 18433 | 111968 | 29443854 |
Neurotoxicity | 149.99 | 16.18 | 101 | 18604 | 14512 | 29541310 |
Cytokine release syndrome | 147.55 | 16.18 | 96 | 18609 | 13023 | 29542799 |
Septic shock | 102.10 | 16.18 | 159 | 18546 | 62401 | 29493421 |
Drug reaction with eosinophilia and systemic symptoms | 96.28 | 16.18 | 103 | 18602 | 27889 | 29527933 |
Multiple organ dysfunction syndrome | 92.83 | 16.18 | 153 | 18552 | 62963 | 29492859 |
Respiratory failure | 88.69 | 16.18 | 192 | 18513 | 96939 | 29458883 |
Pyrexia | 83.65 | 16.18 | 381 | 18324 | 287241 | 29268581 |
Acute generalised exanthematous pustulosis | 78.24 | 16.18 | 47 | 18658 | 5536 | 29550286 |
Fatigue | 72.28 | 16.18 | 57 | 18648 | 316764 | 29239058 |
Tubulointerstitial nephritis | 71.64 | 16.18 | 71 | 18634 | 17572 | 29538250 |
Hypoxia | 71.17 | 16.18 | 116 | 18589 | 47263 | 29508559 |
Clostridium difficile colitis | 70.69 | 16.18 | 62 | 18643 | 13150 | 29542672 |
Renal tubular necrosis | 68.35 | 16.18 | 63 | 18642 | 14252 | 29541570 |
Sepsis | 64.07 | 16.18 | 217 | 18488 | 142465 | 29413357 |
Myoclonus | 62.43 | 16.18 | 58 | 18647 | 13251 | 29542571 |
Pathogen resistance | 62.26 | 16.18 | 47 | 18658 | 8069 | 29547753 |
Neutrophil count decreased | 57.89 | 16.18 | 101 | 18604 | 43466 | 29512356 |
Mental status changes | 57.23 | 16.18 | 89 | 18616 | 34838 | 29520984 |
Methaemoglobinaemia | 55.16 | 16.18 | 29 | 18676 | 2642 | 29553180 |
Neutropenia | 52.79 | 16.18 | 193 | 18512 | 131518 | 29424304 |
Dizziness | 51.46 | 16.18 | 28 | 18677 | 189656 | 29366166 |
Enterococcal infection | 50.77 | 16.18 | 42 | 18663 | 8226 | 29547596 |
Product dose omission issue | 49.02 | 16.18 | 3 | 18702 | 96380 | 29459442 |
Immune effector cell-associated neurotoxicity syndrome | 47.79 | 16.18 | 22 | 18683 | 1502 | 29554320 |
Death | 46.10 | 16.18 | 92 | 18613 | 341992 | 29213830 |
Brain herniation | 44.32 | 16.18 | 28 | 18677 | 3605 | 29552217 |
Meningitis candida | 42.79 | 16.18 | 10 | 18695 | 71 | 29555751 |
Disseminated intravascular coagulation | 41.56 | 16.18 | 57 | 18648 | 19923 | 29535899 |
Nephropathy toxic | 41.29 | 16.18 | 42 | 18663 | 10714 | 29545108 |
Status epilepticus | 41.17 | 16.18 | 42 | 18663 | 10752 | 29545070 |
Haemodialysis | 40.29 | 16.18 | 40 | 18665 | 9914 | 29545908 |
Myocardial infarction | 38.53 | 16.18 | 11 | 18694 | 110285 | 29445537 |
Bacteraemia | 36.13 | 16.18 | 48 | 18657 | 16275 | 29539547 |
Pseudomonas infection | 35.65 | 16.18 | 39 | 18666 | 10813 | 29545009 |
Botulism | 35.44 | 16.18 | 10 | 18695 | 160 | 29555662 |
Systemic candida | 35.36 | 16.18 | 22 | 18683 | 2758 | 29553064 |
Platelet count decreased | 35.05 | 16.18 | 145 | 18560 | 104527 | 29451295 |
Glomerulosclerosis | 34.42 | 16.18 | 14 | 18691 | 706 | 29555116 |
Drug resistance | 34.04 | 16.18 | 54 | 18651 | 21486 | 29534336 |
Blood culture positive | 33.98 | 16.18 | 26 | 18679 | 4551 | 29551271 |
Thrombocytopenia | 33.46 | 16.18 | 171 | 18534 | 134652 | 29421170 |
Fall | 33.11 | 16.18 | 38 | 18667 | 177140 | 29378682 |
Antibiotic level above therapeutic | 32.89 | 16.18 | 10 | 18695 | 210 | 29555612 |
Immune thrombocytopenia | 32.52 | 16.18 | 32 | 18673 | 7845 | 29547977 |
Bronchopulmonary aspergillosis | 31.57 | 16.18 | 39 | 18666 | 12305 | 29543517 |
Uraemic encephalopathy | 30.69 | 16.18 | 10 | 18695 | 265 | 29555557 |
Clostridium difficile infection | 30.52 | 16.18 | 44 | 18661 | 16097 | 29539725 |
Aspergillus infection | 29.62 | 16.18 | 35 | 18670 | 10546 | 29545276 |
Confusional state | 29.52 | 16.18 | 159 | 18546 | 127718 | 29428104 |
Cytomegalovirus enterocolitis | 29.51 | 16.18 | 13 | 18692 | 800 | 29555022 |
Arthralgia | 29.41 | 16.18 | 27 | 18678 | 139590 | 29416232 |
Depression | 28.81 | 16.18 | 9 | 18696 | 85138 | 29470684 |
Disseminated mucormycosis | 28.44 | 16.18 | 10 | 18695 | 336 | 29555486 |
White blood cell count decreased | 28.30 | 16.18 | 116 | 18589 | 83246 | 29472576 |
Candida infection | 28.06 | 16.18 | 41 | 18664 | 15184 | 29540638 |
Aspartate aminotransferase increased | 27.75 | 16.18 | 92 | 18613 | 59633 | 29496189 |
Eosinophilia | 27.64 | 16.18 | 50 | 18655 | 22111 | 29533711 |
Pleural effusion | 27.59 | 16.18 | 104 | 18601 | 71804 | 29484018 |
Metabolic encephalopathy | 27.50 | 16.18 | 21 | 18684 | 3666 | 29552156 |
Burkholderia test positive | 26.95 | 16.18 | 13 | 18692 | 986 | 29554836 |
Cytomegalovirus viraemia | 26.70 | 16.18 | 26 | 18679 | 6294 | 29549528 |
Malaise | 25.93 | 16.18 | 38 | 18667 | 159564 | 29396258 |
Enterocolitis | 25.53 | 16.18 | 26 | 18679 | 6640 | 29549182 |
Weight decreased | 25.43 | 16.18 | 35 | 18670 | 150870 | 29404952 |
Acute respiratory distress syndrome | 25.18 | 16.18 | 49 | 18656 | 22886 | 29532936 |
Klebsiella infection | 25.17 | 16.18 | 27 | 18678 | 7322 | 29548500 |
Rash morbilliform | 25.01 | 16.18 | 17 | 18688 | 2476 | 29553346 |
Acute myeloid leukaemia recurrent | 24.97 | 16.18 | 15 | 18690 | 1765 | 29554057 |
Pain | 24.86 | 16.18 | 44 | 18661 | 171388 | 29384434 |
Transaminases increased | 24.38 | 16.18 | 48 | 18657 | 22614 | 29533208 |
Gait disturbance | 24.37 | 16.18 | 8 | 18697 | 73341 | 29482481 |
Insomnia | 24.17 | 16.18 | 13 | 18692 | 88748 | 29467074 |
Septic embolus | 23.40 | 16.18 | 12 | 18693 | 1038 | 29554784 |
Toxic encephalopathy | 23.38 | 16.18 | 21 | 18684 | 4591 | 29551231 |
Mucormycosis | 23.26 | 16.18 | 22 | 18683 | 5136 | 29550686 |
Cholestasis | 23.22 | 16.18 | 48 | 18657 | 23414 | 29532408 |
Respiratory distress | 23.22 | 16.18 | 58 | 18647 | 32048 | 29523774 |
Bacterial toxaemia | 23.07 | 16.18 | 7 | 18698 | 146 | 29555676 |
Choluria | 23.02 | 16.18 | 7 | 18698 | 147 | 29555675 |
Cytokine storm | 22.83 | 16.18 | 10 | 18695 | 607 | 29555215 |
Corynebacterium infection | 22.73 | 16.18 | 9 | 18696 | 423 | 29555399 |
Trichosporon infection | 22.48 | 16.18 | 10 | 18695 | 630 | 29555192 |
Alanine aminotransferase increased | 21.96 | 16.18 | 96 | 18609 | 70848 | 29484974 |
Renal failure | 21.86 | 16.18 | 139 | 18566 | 118460 | 29437362 |
Pneumonia bacterial | 21.48 | 16.18 | 28 | 18677 | 9315 | 29546507 |
Joint swelling | 21.37 | 16.18 | 3 | 18702 | 49627 | 29506195 |
Blood pressure increased | 21.31 | 16.18 | 10 | 18695 | 73793 | 29482029 |
Fungal infection | 21.19 | 16.18 | 34 | 18671 | 13651 | 29542171 |
Dyspnoea | 21.08 | 16.18 | 121 | 18584 | 326611 | 29229211 |
Hypersensitivity vasculitis | 20.95 | 16.18 | 17 | 18688 | 3240 | 29552582 |
Kidney fibrosis | 20.63 | 16.18 | 14 | 18691 | 2033 | 29553789 |
Cerebral aspergillosis | 20.52 | 16.18 | 12 | 18693 | 1344 | 29554478 |
Acute lymphocytic leukaemia recurrent | 20.25 | 16.18 | 15 | 18690 | 2501 | 29553321 |
Vanishing bile duct syndrome | 20.05 | 16.18 | 9 | 18696 | 579 | 29555243 |
Anxiety | 19.82 | 16.18 | 15 | 18690 | 85350 | 29470472 |
Feeling abnormal | 19.81 | 16.18 | 5 | 18700 | 54440 | 29501382 |
Hospitalisation | 19.29 | 16.18 | 3 | 18702 | 45985 | 29509837 |
Headache | 19.16 | 16.18 | 52 | 18653 | 173955 | 29381867 |
Blood creatinine increased | 19.06 | 16.18 | 105 | 18600 | 84997 | 29470825 |
Toxic epidermal necrolysis | 18.98 | 16.18 | 38 | 18667 | 18115 | 29537707 |
Aphasia | 18.67 | 16.18 | 39 | 18666 | 19159 | 29536663 |
Drug intolerance | 18.48 | 16.18 | 4 | 18701 | 48375 | 29507447 |
Inappropriate schedule of product administration | 18.43 | 16.18 | 3 | 18702 | 44469 | 29511353 |
Procalcitonin increased | 18.41 | 16.18 | 12 | 18693 | 1630 | 29554192 |
Systemic mycosis | 18.19 | 16.18 | 11 | 18694 | 1310 | 29554512 |
Drug level increased | 18.08 | 16.18 | 38 | 18667 | 18749 | 29537073 |
Eye infection fungal | 17.90 | 16.18 | 7 | 18698 | 318 | 29555504 |
Peripheral swelling | 17.84 | 16.18 | 9 | 18696 | 63730 | 29492092 |
Sputum culture positive | 17.70 | 16.18 | 12 | 18693 | 1740 | 29554082 |
Retinal ischaemia | 17.68 | 16.18 | 7 | 18698 | 329 | 29555493 |
Flavobacterium infection | 17.66 | 16.18 | 5 | 18700 | 81 | 29555741 |
Hepatosplenic candidiasis | 17.20 | 16.18 | 6 | 18699 | 197 | 29555625 |
Asthenia | 17.13 | 16.18 | 74 | 18631 | 215176 | 29340646 |
Hypercapnia | 17.01 | 16.18 | 16 | 18689 | 3710 | 29552112 |
Dysbiosis | 16.53 | 16.18 | 7 | 18698 | 391 | 29555431 |
Liver abscess | 16.53 | 16.18 | 15 | 18690 | 3323 | 29552499 |
Staphylococcal sepsis | 16.52 | 16.18 | 24 | 18681 | 8838 | 29546984 |
Adenoviral haemorrhagic cystitis | 16.45 | 16.18 | 7 | 18698 | 396 | 29555426 |
Gastrointestinal mucormycosis | 16.27 | 16.18 | 5 | 18700 | 109 | 29555713 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Encephalopathy | 536.77 | 16.12 | 340 | 30532 | 58479 | 64409381 |
Acute kidney injury | 440.10 | 16.12 | 776 | 30096 | 448464 | 64019396 |
Febrile neutropenia | 352.56 | 16.12 | 441 | 30431 | 187216 | 64280644 |
Neurotoxicity | 318.19 | 16.12 | 185 | 30687 | 27219 | 64440641 |
Cytokine release syndrome | 272.40 | 16.12 | 152 | 30720 | 20677 | 64447183 |
Drug reaction with eosinophilia and systemic symptoms | 206.70 | 16.12 | 186 | 30686 | 54031 | 64413829 |
Status epilepticus | 194.28 | 16.12 | 124 | 30748 | 21539 | 64446321 |
Septic shock | 180.61 | 16.12 | 237 | 30635 | 105200 | 64362660 |
Myoclonus | 175.25 | 16.12 | 123 | 30749 | 24995 | 64442865 |
Pyrexia | 173.42 | 16.12 | 623 | 30249 | 558021 | 63909839 |
Multiple organ dysfunction syndrome | 166.06 | 16.12 | 223 | 30649 | 101190 | 64366670 |
Sepsis | 164.34 | 16.12 | 349 | 30523 | 229992 | 64237868 |
Tubulointerstitial nephritis | 152.49 | 16.12 | 123 | 30749 | 30786 | 64437074 |
Respiratory failure | 147.24 | 16.12 | 271 | 30601 | 160912 | 64306948 |
Mental status changes | 139.60 | 16.12 | 159 | 30713 | 61003 | 64406857 |
Renal tubular necrosis | 128.61 | 16.12 | 97 | 30775 | 22013 | 64445847 |
Thrombocytopenia | 124.01 | 16.12 | 307 | 30565 | 223494 | 64244366 |
Fatigue | 118.28 | 16.12 | 111 | 30761 | 748619 | 63719241 |
Neutrophil count decreased | 114.65 | 16.12 | 162 | 30710 | 77034 | 64390826 |
Clostridium difficile colitis | 112.88 | 16.12 | 98 | 30774 | 27125 | 64440735 |
Hypoxia | 112.17 | 16.12 | 172 | 30700 | 87977 | 64379883 |
Pain | 109.26 | 16.12 | 65 | 30807 | 553446 | 63914414 |
Platelet count decreased | 100.25 | 16.12 | 237 | 30635 | 167474 | 64300386 |
Neutropenia | 99.86 | 16.12 | 296 | 30576 | 239328 | 64228532 |
Arthralgia | 99.02 | 16.12 | 44 | 30828 | 442216 | 64025644 |
Pathogen resistance | 98.28 | 16.12 | 66 | 30806 | 12477 | 64455383 |
Drug resistance | 93.50 | 16.12 | 99 | 30773 | 35003 | 64432857 |
Toxic encephalopathy | 90.01 | 16.12 | 57 | 30815 | 9758 | 64458102 |
Dizziness | 89.88 | 16.12 | 47 | 30825 | 430116 | 64037744 |
Immune effector cell-associated neurotoxicity syndrome | 89.85 | 16.12 | 37 | 30835 | 2558 | 64465302 |
Joint swelling | 83.12 | 16.12 | 5 | 30867 | 215377 | 64252483 |
Acute generalised exanthematous pustulosis | 80.25 | 16.12 | 61 | 30811 | 13997 | 64453863 |
Enterococcal infection | 78.79 | 16.12 | 60 | 30812 | 13806 | 64454054 |
Klebsiella infection | 76.63 | 16.12 | 58 | 30814 | 13223 | 64454637 |
Headache | 76.03 | 16.12 | 85 | 30787 | 529382 | 63938478 |
Nephropathy toxic | 72.50 | 16.12 | 63 | 30809 | 17451 | 64450409 |
Product dose omission issue | 70.88 | 16.12 | 6 | 30866 | 194741 | 64273119 |
Malaise | 69.39 | 16.12 | 53 | 30819 | 396194 | 64071666 |
Pneumonia | 65.68 | 16.12 | 475 | 30397 | 559101 | 63908759 |
Drug intolerance | 65.22 | 16.12 | 7 | 30865 | 187985 | 64279875 |
Bacteraemia | 63.13 | 16.12 | 71 | 30801 | 26840 | 64441020 |
Rheumatoid arthritis | 59.95 | 16.12 | 5 | 30867 | 164289 | 64303571 |
Clostridium difficile infection | 59.84 | 16.12 | 80 | 30792 | 36083 | 64431777 |
Disseminated intravascular coagulation | 58.87 | 16.12 | 75 | 30797 | 32273 | 64435587 |
White blood cell count decreased | 58.24 | 16.12 | 187 | 30685 | 157650 | 64310210 |
Confusional state | 57.20 | 16.12 | 262 | 30610 | 260882 | 64206978 |
Renal failure | 57.12 | 16.12 | 204 | 30668 | 181484 | 64286376 |
Antibiotic level above therapeutic | 56.40 | 16.12 | 18 | 30854 | 595 | 64467265 |
Fall | 55.42 | 16.12 | 71 | 30801 | 416755 | 64051105 |
Nasopharyngitis | 55.26 | 16.12 | 13 | 30859 | 196060 | 64271800 |
Methaemoglobinaemia | 54.83 | 16.12 | 31 | 30841 | 4317 | 64463543 |
Aspartate aminotransferase increased | 54.66 | 16.12 | 153 | 30719 | 119635 | 64348225 |
Trichosporon infection | 53.55 | 16.12 | 19 | 30853 | 873 | 64466987 |
Alopecia | 53.04 | 16.12 | 8 | 30864 | 165682 | 64302178 |
Metabolic encephalopathy | 52.95 | 16.12 | 38 | 30834 | 7987 | 64459873 |
Acute respiratory distress syndrome | 52.36 | 16.12 | 78 | 30794 | 38857 | 64429003 |
Pseudomonas infection | 52.22 | 16.12 | 53 | 30819 | 17830 | 64450030 |
Peripheral swelling | 51.33 | 16.12 | 18 | 30854 | 209135 | 64258725 |
Bronchopulmonary aspergillosis | 51.12 | 16.12 | 54 | 30818 | 19031 | 64448829 |
Haemodialysis | 50.58 | 16.12 | 51 | 30821 | 17026 | 64450834 |
Pancytopenia | 49.46 | 16.12 | 166 | 30706 | 143143 | 64324717 |
Mucormycosis | 48.98 | 16.12 | 35 | 30837 | 7306 | 64460554 |
Eosinophilia | 47.97 | 16.12 | 74 | 30798 | 38002 | 64429858 |
Brain herniation | 47.90 | 16.12 | 33 | 30839 | 6500 | 64461360 |
Weight decreased | 47.74 | 16.12 | 40 | 30832 | 285699 | 64182161 |
Blood creatinine increased | 47.49 | 16.12 | 158 | 30714 | 135624 | 64332236 |
Arthropathy | 46.07 | 16.12 | 3 | 30869 | 120964 | 64346896 |
Abdominal discomfort | 44.21 | 16.12 | 16 | 30856 | 182306 | 64285554 |
Gait disturbance | 43.66 | 16.12 | 14 | 30858 | 172141 | 64295719 |
Pleural effusion | 43.13 | 16.12 | 146 | 30726 | 126413 | 64341447 |
Cholestasis | 42.84 | 16.12 | 77 | 30795 | 44795 | 64423065 |
Respiratory distress | 42.75 | 16.12 | 84 | 30788 | 52247 | 64415613 |
Toxic epidermal necrolysis | 42.36 | 16.12 | 69 | 30803 | 37097 | 64430763 |
Alanine aminotransferase increased | 41.89 | 16.12 | 154 | 30718 | 138877 | 64328983 |
Systemic candida | 41.65 | 16.12 | 28 | 30844 | 5301 | 64462559 |
Dyspnoea | 41.60 | 16.12 | 190 | 30682 | 718484 | 63749376 |
Myocardial infarction | 41.15 | 16.12 | 14 | 30858 | 165807 | 64302053 |
Cytomegalovirus viraemia | 40.93 | 16.12 | 37 | 30835 | 10791 | 64457069 |
Meningitis candida | 39.98 | 16.12 | 10 | 30862 | 132 | 64467728 |
Fungaemia | 39.83 | 16.12 | 24 | 30848 | 3761 | 64464099 |
Pain in extremity | 38.84 | 16.12 | 53 | 30819 | 303032 | 64164828 |
Depression | 38.24 | 16.12 | 20 | 30852 | 183271 | 64284589 |
Neutropenic colitis | 38.05 | 16.12 | 25 | 30847 | 4556 | 64463304 |
Enterocolitis | 37.64 | 16.12 | 37 | 30835 | 11981 | 64455879 |
Hypotension | 36.05 | 16.12 | 308 | 30564 | 380666 | 64087194 |
Acute respiratory failure | 35.86 | 16.12 | 76 | 30796 | 49858 | 64418002 |
Differentiation syndrome | 35.32 | 16.12 | 18 | 30854 | 2036 | 64465824 |
Septic embolus | 34.91 | 16.12 | 17 | 30855 | 1745 | 64466115 |
Agranulocytosis | 34.47 | 16.12 | 64 | 30808 | 38165 | 64429695 |
Aphasia | 33.82 | 16.12 | 66 | 30806 | 40840 | 64427020 |
Musculoskeletal stiffness | 33.09 | 16.12 | 9 | 30863 | 123197 | 64344663 |
Blood pressure increased | 32.90 | 16.12 | 21 | 30851 | 172531 | 64295329 |
Cholestatic liver injury | 32.82 | 16.12 | 21 | 30851 | 3658 | 64464202 |
Cytomegalovirus enterocolitis | 32.77 | 16.12 | 15 | 30857 | 1340 | 64466520 |
Insomnia | 32.65 | 16.12 | 28 | 30844 | 197808 | 64270052 |
Liver abscess | 32.56 | 16.12 | 24 | 30848 | 5256 | 64462604 |
Hypoaesthesia | 32.39 | 16.12 | 13 | 30859 | 139095 | 64328765 |
Immune thrombocytopenia | 32.38 | 16.12 | 38 | 30834 | 15028 | 64452832 |
Enterococcal bacteraemia | 31.96 | 16.12 | 18 | 30854 | 2487 | 64465373 |
Blood culture positive | 31.95 | 16.12 | 28 | 30844 | 7840 | 64460020 |
Blood bilirubin increased | 31.82 | 16.12 | 79 | 30793 | 57474 | 64410386 |
Pulmonary haemorrhage | 31.45 | 16.12 | 35 | 30837 | 13074 | 64454786 |
Rash morbilliform | 30.87 | 16.12 | 23 | 30849 | 5118 | 64462742 |
Glomerulosclerosis | 30.85 | 16.12 | 13 | 30859 | 952 | 64466908 |
Uraemic encephalopathy | 30.82 | 16.12 | 11 | 30861 | 514 | 64467346 |
Botulism | 30.76 | 16.12 | 10 | 30862 | 351 | 64467509 |
Feeling abnormal | 30.28 | 16.12 | 13 | 30859 | 133589 | 64334271 |
Candida infection | 30.10 | 16.12 | 54 | 30818 | 31365 | 64436495 |
Nausea | 29.98 | 16.12 | 237 | 30635 | 785563 | 63682297 |
Renal impairment | 29.90 | 16.12 | 136 | 30736 | 134881 | 64332979 |
Weight increased | 29.71 | 16.12 | 35 | 30837 | 213313 | 64254547 |
Mixed liver injury | 29.56 | 16.12 | 23 | 30849 | 5458 | 64462402 |
Arthritis | 29.36 | 16.12 | 3 | 30869 | 83811 | 64384049 |
Enterococcal sepsis | 29.35 | 16.12 | 17 | 30855 | 2477 | 64465383 |
Haemophagocytic lymphohistiocytosis | 29.19 | 16.12 | 39 | 30833 | 17570 | 64450290 |
Pneumonia bacterial | 29.17 | 16.12 | 36 | 30836 | 14999 | 64452861 |
Tumour lysis syndrome | 29.13 | 16.12 | 41 | 30831 | 19399 | 64448461 |
Cytomegalovirus test positive | 28.65 | 16.12 | 22 | 30850 | 5122 | 64462738 |
Acute myeloid leukaemia | 28.64 | 16.12 | 49 | 30823 | 27414 | 64440446 |
Muscle spasms | 28.51 | 16.12 | 16 | 30856 | 141007 | 64326853 |
Injection site pain | 28.34 | 16.12 | 9 | 30863 | 111399 | 64356461 |
Hepatic function abnormal | 28.19 | 16.12 | 81 | 30791 | 64232 | 64403628 |
Drug level increased | 28.05 | 16.12 | 55 | 30817 | 34141 | 64433719 |
Off label use | 27.88 | 16.12 | 441 | 30431 | 632365 | 63835495 |
Leukocytosis | 27.75 | 16.12 | 58 | 30814 | 37682 | 64430178 |
Asthma | 27.44 | 16.12 | 6 | 30866 | 95219 | 64372641 |
Disseminated mucormycosis | 27.41 | 16.12 | 10 | 30862 | 498 | 64467362 |
Aspergillus infection | 26.73 | 16.12 | 36 | 30836 | 16343 | 64451517 |
Staphylococcal infection | 25.36 | 16.12 | 67 | 30805 | 50611 | 64417249 |
Lower respiratory tract infection | 25.24 | 16.12 | 7 | 30865 | 94607 | 64373253 |
Nephritis allergic | 25.04 | 16.12 | 10 | 30862 | 638 | 64467222 |
Sinusitis | 24.88 | 16.12 | 20 | 30852 | 145908 | 64321952 |
Bacterial toxaemia | 24.56 | 16.12 | 7 | 30865 | 156 | 64467704 |
Transaminases increased | 24.42 | 16.12 | 61 | 30811 | 44533 | 64423327 |
Anxiety | 24.40 | 16.12 | 37 | 30835 | 202612 | 64265248 |
Corynebacterium infection | 24.25 | 16.12 | 11 | 30861 | 962 | 64466898 |
Activated partial thromboplastin time prolonged | 23.74 | 16.12 | 30 | 30842 | 12801 | 64455059 |
Drug eruption | 23.67 | 16.12 | 53 | 30819 | 36083 | 64431777 |
Graft versus host disease | 23.52 | 16.12 | 31 | 30841 | 13782 | 64454078 |
Hypersensitivity | 23.52 | 16.12 | 36 | 30836 | 196416 | 64271444 |
Enterobacter infection | 23.24 | 16.12 | 17 | 30855 | 3679 | 64464181 |
Pseudomembranous colitis | 23.04 | 16.12 | 19 | 30853 | 4897 | 64462963 |
Delirium | 22.83 | 16.12 | 79 | 30793 | 69115 | 64398745 |
Burkholderia test positive | 22.60 | 16.12 | 9 | 30863 | 570 | 64467290 |
Systemic mycosis | 22.58 | 16.12 | 14 | 30858 | 2309 | 64465551 |
Klebsiella bacteraemia | 22.48 | 16.12 | 14 | 30858 | 2326 | 64465534 |
Gastrooesophageal reflux disease | 22.46 | 16.12 | 6 | 30866 | 83137 | 64384723 |
Paraesthesia | 22.23 | 16.12 | 19 | 30853 | 134503 | 64333357 |
Blood urea increased | 21.71 | 16.12 | 58 | 30814 | 44095 | 64423765 |
Procalcitonin increased | 21.68 | 16.12 | 14 | 30858 | 2477 | 64465383 |
Discomfort | 21.54 | 16.12 | 6 | 30866 | 80872 | 64386988 |
Swelling | 21.54 | 16.12 | 27 | 30845 | 160191 | 64307669 |
Contusion | 21.54 | 16.12 | 14 | 30858 | 113951 | 64353909 |
Lung infiltration | 21.42 | 16.12 | 37 | 30835 | 20852 | 64447008 |
Vanishing bile duct syndrome | 21.41 | 16.12 | 11 | 30861 | 1266 | 64466594 |
Asthenia | 21.35 | 16.12 | 119 | 30753 | 427925 | 64039935 |
Back pain | 21.25 | 16.12 | 56 | 30816 | 250115 | 64217745 |
Cerebral aspergillosis | 21.16 | 16.12 | 12 | 30860 | 1681 | 64466179 |
Pulseless electrical activity | 20.79 | 16.12 | 28 | 30844 | 12711 | 64455149 |
Unresponsive to stimuli | 20.68 | 16.12 | 62 | 30810 | 50331 | 64417529 |
Rash maculo-papular | 20.39 | 16.12 | 59 | 30813 | 46967 | 64420893 |
Respiratory alkalosis | 20.26 | 16.12 | 16 | 30856 | 3881 | 64463979 |
Leukopenia | 20.23 | 16.12 | 99 | 30773 | 101143 | 64366717 |
Acidosis | 20.22 | 16.12 | 33 | 30839 | 17762 | 64450098 |
Memory impairment | 19.95 | 16.12 | 8 | 30864 | 85674 | 64382186 |
Mediastinitis | 19.70 | 16.12 | 9 | 30863 | 800 | 64467060 |
Shock | 19.58 | 16.12 | 51 | 30821 | 38189 | 64429671 |
Escherichia bacteraemia | 19.51 | 16.12 | 18 | 30854 | 5385 | 64462475 |
Small intestinal obstruction | 19.44 | 16.12 | 38 | 30834 | 23535 | 64444325 |
Choluria | 19.36 | 16.12 | 7 | 30865 | 340 | 64467520 |
Serum ferritin increased | 19.27 | 16.12 | 22 | 30850 | 8446 | 64459414 |
Chemotherapeutic drug level increased | 19.26 | 16.12 | 7 | 30865 | 345 | 64467515 |
Chest pain | 19.16 | 16.12 | 54 | 30818 | 235926 | 64231934 |
Death | 19.09 | 16.12 | 144 | 30728 | 482561 | 63985299 |
Device related infection | 19.04 | 16.12 | 44 | 30828 | 30582 | 64437278 |
Laryngeal inflammation | 19.01 | 16.12 | 6 | 30866 | 191 | 64467669 |
Product contamination microbial | 18.95 | 16.12 | 9 | 30863 | 874 | 64466986 |
Cytokine storm | 18.91 | 16.12 | 9 | 30863 | 878 | 64466982 |
Vision blurred | 18.61 | 16.12 | 10 | 30862 | 90306 | 64377554 |
Vertigo | 18.53 | 16.12 | 3 | 30869 | 59008 | 64408852 |
Hyperbilirubinaemia | 18.49 | 16.12 | 35 | 30837 | 21170 | 64446690 |
Systemic lupus erythematosus | 18.48 | 16.12 | 7 | 30865 | 77605 | 64390255 |
Hypertensive heart disease | 18.46 | 16.12 | 15 | 30857 | 3789 | 64464071 |
Flavobacterium infection | 18.44 | 16.12 | 5 | 30867 | 92 | 64467768 |
Drug-induced liver injury | 18.04 | 16.12 | 57 | 30815 | 47586 | 64420274 |
Dyspepsia | 17.90 | 16.12 | 8 | 30864 | 80304 | 64387556 |
Blood lactate dehydrogenase increased | 17.85 | 16.12 | 45 | 30827 | 33033 | 64434827 |
Mucosal inflammation | 17.73 | 16.12 | 68 | 30804 | 62516 | 64405344 |
Acute lymphocytic leukaemia recurrent | 17.71 | 16.12 | 15 | 30857 | 4011 | 64463849 |
Eye infection fungal | 17.57 | 16.12 | 7 | 30865 | 444 | 64467416 |
Injection site erythema | 17.51 | 16.12 | 6 | 30866 | 70794 | 64397066 |
Systemic inflammatory response syndrome | 17.47 | 16.12 | 23 | 30849 | 10212 | 64457648 |
Dialysis | 17.39 | 16.12 | 30 | 30842 | 16890 | 64450970 |
Ureaplasma infection | 17.32 | 16.12 | 8 | 30864 | 730 | 64467130 |
Chest discomfort | 17.30 | 16.12 | 18 | 30854 | 116088 | 64351772 |
Dry mouth | 17.02 | 16.12 | 4 | 30868 | 60414 | 64407446 |
Sputum culture positive | 16.98 | 16.12 | 13 | 30859 | 3013 | 64464847 |
Engraftment syndrome | 16.98 | 16.12 | 9 | 30863 | 1104 | 64466756 |
Blastomycosis | 16.95 | 16.12 | 7 | 30865 | 487 | 64467373 |
Kidney fibrosis | 16.70 | 16.12 | 13 | 30859 | 3088 | 64464772 |
Abdominal pain upper | 16.58 | 16.12 | 37 | 30835 | 174993 | 64292867 |
Tachypnoea | 16.32 | 16.12 | 38 | 30834 | 26533 | 64441327 |
Venoocclusive liver disease | 16.32 | 16.12 | 22 | 30850 | 9993 | 64457867 |
Osteoarthritis | 16.32 | 16.12 | 5 | 30867 | 63331 | 64404529 |
Tonsillitis bacterial | 16.26 | 16.12 | 5 | 30867 | 146 | 64467714 |
Lymphatic disorder | 16.24 | 16.12 | 6 | 30866 | 310 | 64467550 |
Pneumonitis | 16.18 | 16.12 | 57 | 30815 | 50308 | 64417552 |
None
Source | Code | Description |
---|---|---|
ATC | J01DE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Fourth-generation cephalosporins |
ATC | J01RA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Bacterial peritonitis | indication | 197171003 | |
Pneumococcal pneumonia | indication | 233607000 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Complicated Proteus UTI | indication | ||
E. Coli Pyelonephritis | indication | ||
Complicated Urinary Tract Infections | indication | ||
Complicated Bacteroides Peritonitis | indication | ||
Complicated Streptococcus Peritonitis | indication | ||
Klebsiella Pyelonephritis | indication | ||
Complicated E. Coli Peritonitis | indication | ||
Enterobacter Pneumonia | indication | ||
Complicated Klebsiella Peritonitis | indication | ||
Proteus Pyelonephritis | indication | ||
Myoclonus | contraindication | 17450006 | |
Colitis | contraindication | 64226004 | DOID:0060180 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Factor II deficiency | contraindication | 73975000 | |
Disorder of brain | contraindication | 81308009 | DOID:936 |
Seizure disorder | contraindication | 128613002 | |
Impaired renal function disorder | contraindication | 197663003 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.32 | acidic |
pKa2 | 13.31 | acidic |
pKa3 | 3.1 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4024049 | VUID |
N0000022054 | NUI |
D01157 | KEGG_DRUG |
123171-59-5 | SECONDARY_CAS_RN |
20481 | RXNORM |
4020908 | VANDF |
4024049 | VANDF |
C0055003 | UMLSCUI |
CHEBI:478164 | CHEBI |
9WT | PDB_CHEM_ID |
CHEMBL186 | ChEMBL_ID |
CHEMBL1200962 | ChEMBL_ID |
D000077723 | MESH_DESCRIPTOR_UI |
DB01413 | DRUGBANK_ID |
10772 | IUPHAR_LIGAND_ID |
6092 | INN_ID |
807PW4VQE3 | UNII |
5479537 | PUBCHEM_CID |
116681 | MMSL |
4373 | MMSL |
d03882 | MMSL |
004974 | NDDF |
004975 | NDDF |
370370003 | SNOMEDCT_US |
370371004 | SNOMEDCT_US |
96048006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3222 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3223 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-130 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-131 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-240 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-241 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6147 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6147 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-326 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-340 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
CEFEPIME | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66288-8100 | INJECTION, POWDER, FOR SOLUTION | 100 g | INTRAVENOUS | ANDA | 18 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66794-209 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 17 sections |