Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, cefalosporanic acid derivatives | 535 | 88040-23-7 |
Dose | Unit | Route |
---|---|---|
4 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 85 % | Benet LZ, Broccatelli F, Oprea TI |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.28 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.78 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 18, 1996 | FDA | HOSPIRA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 404.19 | 19.03 | 287 | 15052 | 105258 | 56171470 |
Encephalopathy | 399.40 | 19.03 | 194 | 15145 | 35131 | 56241597 |
Acute kidney injury | 304.27 | 19.03 | 350 | 14989 | 240413 | 56036315 |
Neurotoxicity | 222.32 | 19.03 | 101 | 15238 | 15694 | 56261034 |
Status epilepticus | 201.11 | 19.03 | 93 | 15246 | 15048 | 56261680 |
Sepsis | 162.28 | 19.03 | 195 | 15144 | 139645 | 56137083 |
Drug reaction with eosinophilia and systemic symptoms | 155.44 | 19.03 | 99 | 15240 | 30205 | 56246523 |
Cytokine release syndrome | 151.30 | 19.03 | 69 | 15270 | 10806 | 56265922 |
Pyrexia | 141.50 | 19.03 | 335 | 15004 | 418438 | 55858290 |
Multiple organ dysfunction syndrome | 140.90 | 19.03 | 116 | 15223 | 52654 | 56224074 |
Myoclonus | 140.74 | 19.03 | 73 | 15266 | 15130 | 56261598 |
Septic shock | 122.70 | 19.03 | 114 | 15225 | 60721 | 56216007 |
Thrombocytopenia | 115.81 | 19.03 | 163 | 15176 | 136061 | 56140667 |
Respiratory failure | 101.14 | 19.03 | 127 | 15212 | 94935 | 56181793 |
Mental status changes | 99.15 | 19.03 | 82 | 15257 | 37419 | 56239309 |
Pain | 97.59 | 19.03 | 30 | 15309 | 663154 | 55613574 |
Toxic encephalopathy | 93.20 | 19.03 | 41 | 15298 | 5897 | 56270831 |
Acute generalised exanthematous pustulosis | 93.09 | 19.03 | 48 | 15291 | 9821 | 56266907 |
Tubulointerstitial nephritis | 91.84 | 19.03 | 57 | 15282 | 16608 | 56260120 |
Pneumonia | 88.33 | 19.03 | 277 | 15062 | 406821 | 55869907 |
Rheumatoid arthritis | 84.39 | 19.03 | 5 | 15334 | 382599 | 55894129 |
Arthralgia | 74.94 | 19.03 | 22 | 15317 | 501647 | 55775081 |
Klebsiella infection | 71.07 | 19.03 | 37 | 15302 | 7719 | 56269009 |
Clostridium difficile colitis | 69.25 | 19.03 | 50 | 15289 | 18688 | 56258040 |
Fatigue | 65.93 | 19.03 | 71 | 15268 | 788481 | 55488247 |
Alopecia | 64.17 | 19.03 | 4 | 15335 | 293454 | 55983274 |
Neutropenia | 62.52 | 19.03 | 135 | 15204 | 158032 | 56118696 |
Neutrophil count decreased | 61.81 | 19.03 | 72 | 15267 | 49750 | 56226978 |
Platelet count decreased | 59.32 | 19.03 | 105 | 15234 | 106278 | 56170450 |
Pathogen resistance | 58.95 | 19.03 | 30 | 15309 | 5970 | 56270758 |
Hypoxia | 58.86 | 19.03 | 73 | 15266 | 53824 | 56222904 |
Bacteraemia | 58.43 | 19.03 | 42 | 15297 | 15589 | 56261139 |
Abdominal discomfort | 57.14 | 19.03 | 5 | 15334 | 277269 | 55999459 |
Renal tubular necrosis | 57.04 | 19.03 | 36 | 15303 | 10792 | 56265936 |
Immune effector cell-associated neurotoxicity syndrome | 56.87 | 19.03 | 20 | 15319 | 1588 | 56275140 |
Drug resistance | 56.54 | 19.03 | 46 | 15293 | 20496 | 56256232 |
Mixed liver injury | 48.55 | 19.03 | 23 | 15316 | 3921 | 56272807 |
Drug intolerance | 46.70 | 19.03 | 8 | 15331 | 264810 | 56011918 |
Cytomegalovirus test positive | 45.92 | 19.03 | 20 | 15319 | 2806 | 56273922 |
Acute respiratory distress syndrome | 45.92 | 19.03 | 42 | 15297 | 21884 | 56254844 |
Nasopharyngitis | 45.47 | 19.03 | 4 | 15335 | 220955 | 56055773 |
Headache | 44.77 | 19.03 | 52 | 15287 | 558992 | 55717736 |
Fungaemia | 44.46 | 19.03 | 18 | 15321 | 2106 | 56274622 |
Aspartate aminotransferase increased | 42.80 | 19.03 | 79 | 15260 | 82523 | 56194205 |
Malaise | 40.71 | 19.03 | 25 | 15314 | 367835 | 55908893 |
Hypotension | 40.62 | 19.03 | 155 | 15184 | 250353 | 56026375 |
Renal impairment | 39.09 | 19.03 | 75 | 15264 | 80638 | 56196090 |
Shock | 38.60 | 19.03 | 38 | 15301 | 21690 | 56255038 |
Clostridium difficile infection | 38.31 | 19.03 | 42 | 15297 | 27156 | 56249572 |
Respiratory distress | 37.99 | 19.03 | 45 | 15294 | 31622 | 56245106 |
Cholestatic liver injury | 36.80 | 19.03 | 16 | 15323 | 2236 | 56274492 |
Nephropathy toxic | 36.74 | 19.03 | 25 | 15314 | 8502 | 56268226 |
Renal failure | 36.60 | 19.03 | 88 | 15251 | 110412 | 56166316 |
Pancytopenia | 36.47 | 19.03 | 77 | 15262 | 88638 | 56188090 |
Dizziness | 35.81 | 19.03 | 30 | 15309 | 376110 | 55900618 |
Enterococcal infection | 35.64 | 19.03 | 23 | 15316 | 7161 | 56269567 |
Systemic lupus erythematosus | 35.11 | 19.03 | 4 | 15335 | 180074 | 56096654 |
Therapeutic product effect decreased | 35.03 | 19.03 | 3 | 15336 | 169449 | 56107279 |
Product dose omission issue | 34.34 | 19.03 | 7 | 15332 | 204746 | 56071982 |
Antibiotic level above therapeutic | 34.34 | 19.03 | 9 | 15330 | 261 | 56276467 |
Acute respiratory failure | 33.85 | 19.03 | 42 | 15297 | 30952 | 56245776 |
Peripheral swelling | 33.69 | 19.03 | 11 | 15328 | 234715 | 56042013 |
Nephritis allergic | 33.64 | 19.03 | 8 | 15331 | 154 | 56276574 |
Trichosporon infection | 33.64 | 19.03 | 9 | 15330 | 283 | 56276445 |
Blood creatinine increased | 33.42 | 19.03 | 70 | 15269 | 80121 | 56196607 |
Hepatic function abnormal | 33.29 | 19.03 | 44 | 15295 | 34514 | 56242214 |
Differentiation syndrome | 33.14 | 19.03 | 12 | 15327 | 1037 | 56275691 |
Swelling | 33.09 | 19.03 | 12 | 15327 | 239759 | 56036969 |
Confusional state | 33.07 | 19.03 | 128 | 15211 | 208027 | 56068701 |
Pseudomonas infection | 33.00 | 19.03 | 25 | 15314 | 10046 | 56266682 |
Rash maculo-papular | 32.91 | 19.03 | 40 | 15299 | 28867 | 56247861 |
Toxic epidermal necrolysis | 32.72 | 19.03 | 35 | 15304 | 22007 | 56254721 |
Weight decreased | 31.64 | 19.03 | 13 | 15326 | 240701 | 56036027 |
Metabolic encephalopathy | 31.48 | 19.03 | 19 | 15320 | 5261 | 56271467 |
Alanine aminotransferase increased | 31.45 | 19.03 | 75 | 15264 | 93587 | 56183141 |
Sinusitis | 30.66 | 19.03 | 8 | 15331 | 197573 | 56079155 |
Anaemia | 30.61 | 19.03 | 149 | 15190 | 267362 | 56009366 |
Mucormycosis | 30.58 | 19.03 | 15 | 15324 | 2759 | 56273969 |
Encephalitis Japanese B | 30.42 | 19.03 | 6 | 15333 | 45 | 56276683 |
Bronchopulmonary aspergillosis | 30.41 | 19.03 | 22 | 15317 | 8242 | 56268486 |
Enterococcal bacteraemia | 30.27 | 19.03 | 12 | 15327 | 1329 | 56275399 |
Stenotrophomonas infection | 30.23 | 19.03 | 13 | 15326 | 1768 | 56274960 |
Agranulocytosis | 30.20 | 19.03 | 34 | 15305 | 22625 | 56254103 |
Hypertensive heart disease | 29.76 | 19.03 | 14 | 15325 | 2349 | 56274379 |
Toxic skin eruption | 29.62 | 19.03 | 25 | 15314 | 11714 | 56265014 |
White blood cell count decreased | 29.26 | 19.03 | 88 | 15251 | 125902 | 56150826 |
Dysbiosis | 29.02 | 19.03 | 10 | 15329 | 747 | 56275981 |
Hypersensitivity | 28.93 | 19.03 | 17 | 15322 | 256391 | 56020337 |
Eosinophilic pneumonia | 28.93 | 19.03 | 13 | 15326 | 1964 | 56274764 |
Leukocytosis | 28.85 | 19.03 | 34 | 15305 | 23757 | 56252971 |
Neutropenic colitis | 27.78 | 19.03 | 14 | 15325 | 2729 | 56273999 |
Klebsiella bacteraemia | 26.09 | 19.03 | 11 | 15328 | 1425 | 56275303 |
Acute graft versus host disease in skin | 25.73 | 19.03 | 14 | 15325 | 3188 | 56273540 |
Eosinophilia | 24.86 | 19.03 | 29 | 15310 | 20048 | 56256680 |
Graft versus host disease | 24.83 | 19.03 | 18 | 15321 | 6763 | 56269965 |
Musculoskeletal stiffness | 24.81 | 19.03 | 6 | 15333 | 156001 | 56120727 |
Chemotherapeutic drug level increased | 24.35 | 19.03 | 6 | 15333 | 135 | 56276593 |
Hyperbilirubinaemia | 24.20 | 19.03 | 21 | 15318 | 10214 | 56266514 |
Leukopenia | 24.02 | 19.03 | 57 | 15282 | 70883 | 56205845 |
Metabolic acidosis | 23.91 | 19.03 | 41 | 15298 | 40413 | 56236315 |
Aphasia | 23.73 | 19.03 | 35 | 15304 | 30380 | 56246348 |
Staphylococcal infection | 23.39 | 19.03 | 39 | 15300 | 37579 | 56239149 |
Hyperoxaluria | 23.20 | 19.03 | 6 | 15333 | 165 | 56276563 |
Engraft failure | 23.07 | 19.03 | 7 | 15332 | 348 | 56276380 |
Product use issue | 22.94 | 19.03 | 11 | 15328 | 186030 | 56090698 |
Gait disturbance | 22.82 | 19.03 | 8 | 15331 | 163313 | 56113415 |
Cholestasis | 22.50 | 19.03 | 32 | 15307 | 26881 | 56249847 |
Disseminated intravascular coagulation | 22.42 | 19.03 | 26 | 15313 | 17859 | 56258869 |
Weight increased | 22.22 | 19.03 | 18 | 15321 | 229685 | 56047043 |
Candida infection | 22.17 | 19.03 | 31 | 15308 | 25636 | 56251092 |
Cytomegalovirus viraemia | 22.03 | 19.03 | 15 | 15324 | 5105 | 56271623 |
Fall | 21.92 | 19.03 | 40 | 15299 | 357470 | 55919258 |
Acute myeloid leukaemia | 21.83 | 19.03 | 25 | 15314 | 16947 | 56259781 |
Thrombotic microangiopathy | 21.63 | 19.03 | 19 | 15320 | 9392 | 56267336 |
Hypoaesthesia | 21.43 | 19.03 | 6 | 15333 | 141485 | 56135243 |
Pseudomembranous colitis | 21.43 | 19.03 | 12 | 15327 | 2891 | 56273837 |
Blood bilirubin increased | 21.30 | 19.03 | 35 | 15304 | 33319 | 56243409 |
Delirium | 21.18 | 19.03 | 40 | 15299 | 42477 | 56234251 |
Vascular device infection | 20.84 | 19.03 | 15 | 15324 | 5575 | 56271153 |
Asthma | 20.77 | 19.03 | 3 | 15336 | 112767 | 56163961 |
Ileus | 20.53 | 19.03 | 22 | 15317 | 13860 | 56262868 |
Enterococcal sepsis | 20.28 | 19.03 | 9 | 15330 | 1321 | 56275407 |
Respiratory alkalosis | 20.08 | 19.03 | 11 | 15328 | 2540 | 56274188 |
Pericarditis | 19.83 | 19.03 | 3 | 15336 | 108920 | 56167808 |
Tonsillitis bacterial | 19.82 | 19.03 | 5 | 15334 | 124 | 56276604 |
Laryngeal inflammation | 19.53 | 19.03 | 5 | 15334 | 132 | 56276596 |
Angiokeratoma | 19.38 | 19.03 | 5 | 15334 | 136 | 56276592 |
Eosinophilic pneumonia acute | 19.22 | 19.03 | 6 | 15333 | 328 | 56276400 |
Pleural effusion | 19.17 | 19.03 | 59 | 15280 | 85421 | 56191307 |
Venoocclusive liver disease | 19.13 | 19.03 | 13 | 15326 | 4408 | 56272320 |
Lower respiratory tract infection | 19.08 | 19.03 | 4 | 15335 | 114790 | 56161938 |
Electrocardiogram T wave alternans | 19.08 | 19.03 | 4 | 15335 | 42 | 56276686 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 257.45 | 16.13 | 349 | 19670 | 121500 | 31555825 |
Encephalopathy | 234.30 | 16.13 | 181 | 19838 | 32293 | 31645032 |
Acute kidney injury | 214.50 | 16.13 | 514 | 19505 | 279200 | 31398125 |
Cytokine release syndrome | 166.15 | 16.13 | 113 | 19906 | 16529 | 31660796 |
Neurotoxicity | 161.57 | 16.13 | 110 | 19909 | 16116 | 31661209 |
Septic shock | 115.01 | 16.13 | 173 | 19846 | 65985 | 31611340 |
Drug reaction with eosinophilia and systemic symptoms | 106.12 | 16.13 | 112 | 19907 | 29906 | 31647419 |
Pyrexia | 101.41 | 16.13 | 419 | 19600 | 303421 | 31373904 |
Multiple organ dysfunction syndrome | 101.40 | 16.13 | 166 | 19853 | 68037 | 31609288 |
Respiratory failure | 95.66 | 16.13 | 203 | 19816 | 101246 | 31576079 |
Fatigue | 79.20 | 16.13 | 58 | 19961 | 335148 | 31342177 |
Acute generalised exanthematous pustulosis | 74.89 | 16.13 | 47 | 19972 | 5993 | 31671332 |
Renal tubular necrosis | 74.56 | 16.13 | 67 | 19952 | 14692 | 31662633 |
Sepsis | 73.75 | 16.13 | 237 | 19782 | 151692 | 31525633 |
Clostridium difficile colitis | 73.36 | 16.13 | 65 | 19954 | 13991 | 31663334 |
Pathogen resistance | 72.67 | 16.13 | 53 | 19966 | 8648 | 31668677 |
Hypoxia | 71.43 | 16.13 | 120 | 19899 | 50193 | 31627132 |
Tubulointerstitial nephritis | 68.90 | 16.13 | 71 | 19948 | 18425 | 31658900 |
Immune effector cell-associated neurotoxicity syndrome | 66.15 | 16.13 | 32 | 19987 | 2447 | 31674878 |
Myoclonus | 63.83 | 16.13 | 60 | 19959 | 13930 | 31663395 |
Neutrophil count decreased | 63.66 | 16.13 | 109 | 19910 | 46285 | 31631040 |
Mental status changes | 60.93 | 16.13 | 93 | 19926 | 35875 | 31641450 |
Methaemoglobinaemia | 57.50 | 16.13 | 31 | 19988 | 2975 | 31674350 |
Dizziness | 55.95 | 16.13 | 28 | 19991 | 199119 | 31478206 |
Neutropenia | 55.85 | 16.13 | 205 | 19814 | 140159 | 31537166 |
Enterococcal infection | 55.02 | 16.13 | 45 | 19974 | 8686 | 31668639 |
Product dose omission issue | 51.53 | 16.13 | 4 | 20015 | 105582 | 31571743 |
Disseminated intravascular coagulation | 46.47 | 16.13 | 61 | 19958 | 20476 | 31656849 |
Death | 45.84 | 16.13 | 100 | 19919 | 360469 | 31316856 |
Bacteraemia | 44.02 | 16.13 | 55 | 19964 | 17579 | 31659746 |
Brain herniation | 43.36 | 16.13 | 28 | 19991 | 3749 | 31673576 |
Pseudomonas infection | 42.88 | 16.13 | 44 | 19975 | 11357 | 31665968 |
Meningitis candida | 42.81 | 16.13 | 10 | 20009 | 71 | 31677254 |
Septic embolus | 40.84 | 16.13 | 18 | 20001 | 1111 | 31676214 |
Status epilepticus | 40.68 | 16.13 | 44 | 19975 | 12062 | 31665263 |
Haemodialysis | 40.03 | 16.13 | 40 | 19979 | 10005 | 31667320 |
Nephropathy toxic | 39.45 | 16.13 | 42 | 19977 | 11311 | 31666014 |
Myocardial infarction | 38.30 | 16.13 | 12 | 20007 | 113442 | 31563883 |
Drug resistance | 37.40 | 16.13 | 59 | 19960 | 23394 | 31653931 |
Fall | 36.78 | 16.13 | 38 | 19981 | 186051 | 31491274 |
Bronchopulmonary aspergillosis | 36.41 | 16.13 | 44 | 19975 | 13590 | 31663735 |
Platelet count decreased | 35.55 | 16.13 | 151 | 19868 | 110284 | 31567041 |
Thrombocytopenia | 35.51 | 16.13 | 181 | 19838 | 142566 | 31534759 |
Botulism | 35.45 | 16.13 | 10 | 20009 | 160 | 31677165 |
Glomerulosclerosis | 34.25 | 16.13 | 14 | 20005 | 716 | 31676609 |
Acute respiratory distress syndrome | 34.09 | 16.13 | 58 | 19961 | 24482 | 31652843 |
Blood culture positive | 33.91 | 16.13 | 26 | 19993 | 4572 | 31672753 |
Arthralgia | 33.36 | 16.13 | 28 | 19991 | 151396 | 31525929 |
Systemic candida | 32.64 | 16.13 | 22 | 19997 | 3164 | 31674161 |
Clostridium difficile infection | 32.58 | 16.13 | 47 | 19972 | 17232 | 31660093 |
White blood cell count decreased | 32.49 | 16.13 | 125 | 19894 | 87273 | 31590052 |
Confusional state | 32.42 | 16.13 | 168 | 19851 | 133166 | 31544159 |
Immune thrombocytopenia | 32.32 | 16.13 | 33 | 19986 | 8465 | 31668860 |
Aspergillus infection | 32.09 | 16.13 | 38 | 19981 | 11490 | 31665835 |
Antibiotic level above therapeutic | 31.88 | 16.13 | 10 | 20009 | 234 | 31677091 |
Depression | 31.75 | 16.13 | 9 | 20010 | 90806 | 31586519 |
Eosinophilia | 31.04 | 16.13 | 54 | 19965 | 23199 | 31654126 |
Klebsiella infection | 30.96 | 16.13 | 31 | 19988 | 7772 | 31669553 |
Uraemic encephalopathy | 30.67 | 16.13 | 10 | 20009 | 266 | 31677059 |
Aspartate aminotransferase increased | 30.47 | 16.13 | 98 | 19921 | 62621 | 31614704 |
Pain | 29.72 | 16.13 | 45 | 19974 | 186714 | 31490611 |
Pneumonia | 28.51 | 16.13 | 330 | 19689 | 334982 | 31342343 |
Cytomegalovirus enterocolitis | 28.32 | 16.13 | 13 | 20006 | 883 | 31676442 |
Mucormycosis | 27.56 | 16.13 | 25 | 19994 | 5545 | 31671780 |
Candida infection | 27.46 | 16.13 | 42 | 19977 | 16216 | 31661109 |
Malaise | 27.39 | 16.13 | 40 | 19979 | 168471 | 31508854 |
Enterocolitis | 27.22 | 16.13 | 28 | 19991 | 7246 | 31670079 |
Insomnia | 27.09 | 16.13 | 13 | 20006 | 94823 | 31582502 |
Burkholderia test positive | 26.69 | 16.13 | 13 | 20006 | 1009 | 31676316 |
Metabolic encephalopathy | 26.53 | 16.13 | 21 | 19998 | 3868 | 31673457 |
Gait disturbance | 26.50 | 16.13 | 8 | 20011 | 77487 | 31599838 |
Weight decreased | 25.97 | 16.13 | 38 | 19981 | 159914 | 31517411 |
Pneumonia bacterial | 25.51 | 16.13 | 32 | 19987 | 10264 | 31667061 |
Disseminated mucormycosis | 25.43 | 16.13 | 10 | 20009 | 462 | 31676863 |
Cytomegalovirus viraemia | 25.37 | 16.13 | 26 | 19993 | 6699 | 31670626 |
Pleural effusion | 25.30 | 16.13 | 104 | 19915 | 74816 | 31602509 |
Transaminases increased | 24.37 | 16.13 | 50 | 19969 | 24291 | 31653034 |
Dyspnoea | 24.36 | 16.13 | 123 | 19896 | 343356 | 31333969 |
Blood pressure increased | 24.18 | 16.13 | 10 | 20009 | 79623 | 31597702 |
Respiratory distress | 23.68 | 16.13 | 60 | 19959 | 33493 | 31643832 |
Rash morbilliform | 23.63 | 16.13 | 17 | 20002 | 2714 | 31674611 |
Acute myeloid leukaemia recurrent | 23.57 | 16.13 | 15 | 20004 | 1959 | 31675366 |
Joint swelling | 23.51 | 16.13 | 3 | 20016 | 53428 | 31623897 |
Alanine aminotransferase increased | 23.16 | 16.13 | 101 | 19918 | 74555 | 31602770 |
Bacterial toxaemia | 23.08 | 16.13 | 7 | 20012 | 146 | 31677179 |
Choluria | 22.77 | 16.13 | 7 | 20012 | 153 | 31677172 |
Aeromonas infection | 22.59 | 16.13 | 8 | 20011 | 275 | 31677050 |
Cytokine storm | 22.58 | 16.13 | 10 | 20009 | 624 | 31676701 |
Toxic encephalopathy | 22.50 | 16.13 | 21 | 19998 | 4829 | 31672496 |
Anxiety | 22.38 | 16.13 | 15 | 20004 | 91018 | 31586307 |
Inappropriate schedule of product administration | 22.01 | 16.13 | 3 | 20016 | 50820 | 31626505 |
Trichosporon infection | 21.67 | 16.13 | 10 | 20009 | 687 | 31676638 |
Corynebacterium infection | 21.19 | 16.13 | 9 | 20010 | 507 | 31676818 |
Feeling abnormal | 21.15 | 16.13 | 5 | 20014 | 56997 | 31620328 |
Cholestasis | 21.09 | 16.13 | 48 | 19971 | 25027 | 31652298 |
Hypersensitivity vasculitis | 20.88 | 16.13 | 17 | 20002 | 3258 | 31674067 |
Headache | 20.80 | 16.13 | 54 | 19965 | 183598 | 31493727 |
Blood creatinine increased | 20.77 | 16.13 | 111 | 19908 | 88967 | 31588358 |
Renal failure | 20.67 | 16.13 | 141 | 19878 | 123189 | 31554136 |
Toxic epidermal necrolysis | 20.61 | 16.13 | 41 | 19978 | 19483 | 31657842 |
Drug intolerance | 20.46 | 16.13 | 4 | 20015 | 52029 | 31625296 |
Kidney fibrosis | 20.26 | 16.13 | 14 | 20005 | 2096 | 31675229 |
Organising pneumonia | 20.24 | 16.13 | 21 | 19998 | 5489 | 31671836 |
Cerebral aspergillosis | 20.20 | 16.13 | 12 | 20007 | 1386 | 31675939 |
Off label use | 20.08 | 16.13 | 319 | 19700 | 346955 | 31330370 |
Peripheral swelling | 19.84 | 16.13 | 9 | 20010 | 67856 | 31609469 |
Fungal infection | 19.69 | 16.13 | 34 | 19985 | 14517 | 31662808 |
Vanishing bile duct syndrome | 19.59 | 16.13 | 9 | 20010 | 612 | 31676713 |
Hospitalisation | 19.23 | 16.13 | 4 | 20015 | 49803 | 31627522 |
Asthenia | 19.21 | 16.13 | 75 | 19944 | 224680 | 31452645 |
Procalcitonin increased | 18.22 | 16.13 | 12 | 20007 | 1661 | 31675664 |
Haemophagocytic lymphohistiocytosis | 18.09 | 16.13 | 29 | 19990 | 11649 | 31665676 |
Disseminated cryptococcosis | 17.91 | 16.13 | 11 | 20008 | 1349 | 31675976 |
Aphasia | 17.71 | 16.13 | 39 | 19980 | 19892 | 31657433 |
Flavobacterium infection | 17.67 | 16.13 | 5 | 20014 | 81 | 31677244 |
Sputum culture positive | 17.66 | 16.13 | 12 | 20007 | 1749 | 31675576 |
Acute respiratory failure | 17.58 | 16.13 | 48 | 19971 | 28007 | 31649318 |
Retinal ischaemia | 17.57 | 16.13 | 7 | 20012 | 335 | 31676990 |
Lactobacillus infection | 17.53 | 16.13 | 6 | 20013 | 186 | 31677139 |
Enterobacter infection | 17.46 | 16.13 | 13 | 20006 | 2187 | 31675138 |
Drug level increased | 17.37 | 16.13 | 39 | 19980 | 20147 | 31657178 |
Acute lymphocytic leukaemia recurrent | 17.21 | 16.13 | 15 | 20004 | 3155 | 31674170 |
Systemic mycosis | 17.20 | 16.13 | 11 | 20008 | 1448 | 31675877 |
Eye infection fungal | 17.20 | 16.13 | 7 | 20012 | 354 | 31676971 |
Pancytopenia | 17.18 | 16.13 | 104 | 19915 | 87212 | 31590113 |
Hepatosplenic candidiasis | 16.84 | 16.13 | 6 | 20013 | 210 | 31677115 |
Delirium | 16.84 | 16.13 | 61 | 19958 | 41360 | 31635965 |
Vascular device infection | 16.64 | 16.13 | 15 | 20004 | 3300 | 31674025 |
Musculoskeletal stiffness | 16.62 | 16.13 | 3 | 20016 | 41322 | 31636003 |
Dysbiosis | 16.42 | 16.13 | 7 | 20012 | 398 | 31676927 |
Foetal exposure during pregnancy | 16.37 | 16.13 | 3 | 20016 | 40873 | 31636452 |
Adenoviral haemorrhagic cystitis | 16.27 | 16.13 | 7 | 20012 | 407 | 31676918 |
Hypotension | 16.26 | 16.13 | 199 | 19820 | 204419 | 31472906 |
Hypercapnia | 16.16 | 16.13 | 16 | 20003 | 3955 | 31673370 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 568.67 | 16.13 | 583 | 32713 | 203735 | 70691413 |
Encephalopathy | 565.43 | 16.13 | 355 | 32941 | 61306 | 70833842 |
Acute kidney injury | 470.11 | 16.13 | 815 | 32481 | 473809 | 70421339 |
Neurotoxicity | 362.43 | 16.13 | 206 | 33090 | 29620 | 70865528 |
Cytokine release syndrome | 311.36 | 16.13 | 179 | 33117 | 26288 | 70868860 |
Drug reaction with eosinophilia and systemic symptoms | 234.50 | 16.13 | 204 | 33092 | 57809 | 70837339 |
Septic shock | 211.55 | 16.13 | 262 | 33034 | 111996 | 70783152 |
Pyrexia | 205.02 | 16.13 | 687 | 32609 | 606265 | 70288883 |
Status epilepticus | 201.72 | 16.13 | 132 | 33164 | 24394 | 70870754 |
Sepsis | 195.56 | 16.13 | 384 | 32912 | 244161 | 70650987 |
Multiple organ dysfunction syndrome | 189.73 | 16.13 | 244 | 33052 | 108271 | 70786877 |
Myoclonus | 181.32 | 16.13 | 127 | 33169 | 26228 | 70868920 |
Respiratory failure | 170.17 | 16.13 | 293 | 33003 | 168442 | 70726706 |
Mental status changes | 155.21 | 16.13 | 169 | 33127 | 62932 | 70832216 |
Tubulointerstitial nephritis | 147.26 | 16.13 | 123 | 33173 | 32953 | 70862195 |
Thrombocytopenia | 141.01 | 16.13 | 332 | 32964 | 238778 | 70656370 |
Renal tubular necrosis | 135.07 | 16.13 | 101 | 33195 | 23070 | 70872078 |
Fatigue | 131.12 | 16.13 | 117 | 33179 | 824202 | 70070946 |
Pain | 128.14 | 16.13 | 68 | 33228 | 628748 | 70266400 |
Immune effector cell-associated neurotoxicity syndrome | 122.89 | 16.13 | 52 | 33244 | 3926 | 70891222 |
Neutrophil count decreased | 120.26 | 16.13 | 171 | 33125 | 83385 | 70811763 |
Hypoxia | 119.84 | 16.13 | 181 | 33115 | 93163 | 70801985 |
Clostridium difficile colitis | 117.16 | 16.13 | 102 | 33194 | 28894 | 70866254 |
Rheumatoid arthritis | 115.69 | 16.13 | 5 | 33291 | 291800 | 70603348 |
Arthralgia | 115.58 | 16.13 | 46 | 33250 | 503344 | 70391804 |
Pathogen resistance | 112.92 | 16.13 | 73 | 33223 | 13206 | 70881942 |
Neutropenia | 109.38 | 16.13 | 316 | 32980 | 256840 | 70638308 |
Acute generalised exanthematous pustulosis | 107.76 | 16.13 | 75 | 33221 | 15322 | 70879826 |
Platelet count decreased | 101.22 | 16.13 | 244 | 33052 | 177978 | 70717170 |
Pneumonia | 99.82 | 16.13 | 546 | 32750 | 595686 | 70299462 |
Joint swelling | 98.22 | 16.13 | 5 | 33291 | 253206 | 70641942 |
Dizziness | 97.71 | 16.13 | 48 | 33248 | 464093 | 70431055 |
Drug resistance | 96.88 | 16.13 | 104 | 33192 | 38086 | 70857062 |
Toxic encephalopathy | 92.92 | 16.13 | 59 | 33237 | 10347 | 70884801 |
Klebsiella infection | 89.37 | 16.13 | 65 | 33231 | 14227 | 70880921 |
Enterococcal infection | 85.96 | 16.13 | 64 | 33232 | 14518 | 70880630 |
Bacteraemia | 83.62 | 16.13 | 85 | 33211 | 29224 | 70865924 |
Headache | 77.84 | 16.13 | 95 | 33201 | 580310 | 70314838 |
Product dose omission issue | 76.46 | 16.13 | 7 | 33289 | 217461 | 70677687 |
Malaise | 74.09 | 16.13 | 57 | 33239 | 432875 | 70462273 |
Nephropathy toxic | 70.53 | 16.13 | 63 | 33233 | 18451 | 70876697 |
Drug intolerance | 70.17 | 16.13 | 11 | 33285 | 225676 | 70669472 |
Acute respiratory distress syndrome | 69.25 | 16.13 | 91 | 33205 | 41163 | 70853985 |
Disseminated intravascular coagulation | 65.74 | 16.13 | 80 | 33216 | 33518 | 70861630 |
Alopecia | 65.65 | 16.13 | 8 | 33288 | 198482 | 70696666 |
Nasopharyngitis | 62.32 | 16.13 | 14 | 33282 | 222192 | 70672956 |
Pseudomonas infection | 61.44 | 16.13 | 59 | 33237 | 18935 | 70876213 |
Clostridium difficile infection | 61.13 | 16.13 | 83 | 33213 | 38733 | 70856415 |
White blood cell count decreased | 60.93 | 16.13 | 197 | 33099 | 169944 | 70725204 |
Aspartate aminotransferase increased | 60.74 | 16.13 | 163 | 33133 | 126815 | 70768333 |
Fall | 60.21 | 16.13 | 72 | 33224 | 444024 | 70451124 |
Peripheral swelling | 58.63 | 16.13 | 19 | 33277 | 236544 | 70658604 |
Bronchopulmonary aspergillosis | 58.25 | 16.13 | 60 | 33236 | 20942 | 70874206 |
Arthropathy | 58.04 | 16.13 | 3 | 33293 | 150054 | 70745094 |
Methaemoglobinaemia | 57.93 | 16.13 | 33 | 33263 | 4753 | 70890395 |
Confusional state | 57.53 | 16.13 | 275 | 33021 | 284123 | 70611025 |
Renal failure | 57.26 | 16.13 | 207 | 33089 | 188863 | 70706285 |
Brain herniation | 56.10 | 16.13 | 37 | 33259 | 6919 | 70888229 |
Mucormycosis | 55.99 | 16.13 | 39 | 33257 | 7975 | 70887173 |
Antibiotic level above therapeutic | 55.89 | 16.13 | 18 | 33278 | 625 | 70894523 |
Blood creatinine increased | 54.32 | 16.13 | 169 | 33127 | 142832 | 70752316 |
Abdominal discomfort | 53.62 | 16.13 | 17 | 33279 | 214641 | 70680507 |
Pancytopenia | 53.23 | 16.13 | 174 | 33122 | 150933 | 70744215 |
Trichosporon infection | 52.53 | 16.13 | 19 | 33277 | 942 | 70894206 |
Metabolic encephalopathy | 52.20 | 16.13 | 38 | 33258 | 8325 | 70886823 |
Eosinophilia | 51.44 | 16.13 | 78 | 33218 | 40241 | 70854907 |
Haemodialysis | 50.69 | 16.13 | 51 | 33245 | 17315 | 70877833 |
Weight decreased | 50.42 | 16.13 | 43 | 33253 | 310445 | 70584703 |
Respiratory distress | 47.42 | 16.13 | 89 | 33207 | 54561 | 70840587 |
Pleural effusion | 46.79 | 16.13 | 153 | 33143 | 132711 | 70762437 |
Septic embolus | 46.66 | 16.13 | 21 | 33275 | 1839 | 70893309 |
Gait disturbance | 45.62 | 16.13 | 15 | 33281 | 185091 | 70710057 |
Toxic epidermal necrolysis | 45.55 | 16.13 | 73 | 33223 | 39484 | 70855664 |
Dyspnoea | 45.32 | 16.13 | 197 | 33099 | 769863 | 70125285 |
Alanine aminotransferase increased | 45.08 | 16.13 | 162 | 33134 | 147318 | 70747830 |
Acute respiratory failure | 43.62 | 16.13 | 85 | 33211 | 53580 | 70841568 |
Hypotension | 42.61 | 16.13 | 330 | 32966 | 404051 | 70491097 |
Pain in extremity | 42.53 | 16.13 | 55 | 33241 | 328027 | 70567121 |
Musculoskeletal stiffness | 42.04 | 16.13 | 9 | 33287 | 147751 | 70747397 |
Candida infection | 41.60 | 16.13 | 65 | 33231 | 34408 | 70860740 |
Cholestasis | 41.58 | 16.13 | 78 | 33218 | 47794 | 70847354 |
Depression | 41.14 | 16.13 | 21 | 33275 | 198953 | 70696195 |
Fungaemia | 41.14 | 16.13 | 25 | 33271 | 4057 | 70891091 |
Neutropenic colitis | 40.75 | 16.13 | 27 | 33269 | 5087 | 70890061 |
Cholestatic liver injury | 40.66 | 16.13 | 25 | 33271 | 4143 | 70891005 |
Agranulocytosis | 40.55 | 16.13 | 70 | 33226 | 40228 | 70854920 |
Myocardial infarction | 40.42 | 16.13 | 15 | 33281 | 171630 | 70723518 |
Meningitis candida | 40.04 | 16.13 | 10 | 33286 | 134 | 70895014 |
Differentiation syndrome | 39.91 | 16.13 | 20 | 33276 | 2227 | 70892921 |
Systemic candida | 39.41 | 16.13 | 28 | 33268 | 5906 | 70889242 |
Enterocolitis | 39.29 | 16.13 | 39 | 33257 | 13027 | 70882121 |
Cytomegalovirus viraemia | 39.13 | 16.13 | 37 | 33259 | 11648 | 70883500 |
Blood bilirubin increased | 38.31 | 16.13 | 86 | 33210 | 59815 | 70835333 |
Insomnia | 38.06 | 16.13 | 28 | 33268 | 217778 | 70677370 |
Blood pressure increased | 37.36 | 16.13 | 21 | 33275 | 188496 | 70706652 |
Asthma | 37.27 | 16.13 | 6 | 33290 | 120787 | 70774361 |
Delirium | 36.89 | 16.13 | 97 | 33199 | 74517 | 70820631 |
Staphylococcal infection | 35.65 | 16.13 | 78 | 33218 | 53326 | 70841822 |
Hypoaesthesia | 35.26 | 16.13 | 14 | 33282 | 153725 | 70741423 |
Renal impairment | 34.93 | 16.13 | 147 | 33149 | 143790 | 70751358 |
Off label use | 34.89 | 16.13 | 515 | 32781 | 742545 | 70152603 |
Pneumonia bacterial | 34.80 | 16.13 | 41 | 33255 | 16600 | 70878548 |
Nausea | 34.77 | 16.13 | 246 | 33050 | 851842 | 70043306 |
Weight increased | 34.18 | 16.13 | 38 | 33258 | 242293 | 70652855 |
Haemophagocytic lymphohistiocytosis | 34.05 | 16.13 | 44 | 33252 | 19568 | 70875580 |
Vascular device infection | 33.95 | 16.13 | 29 | 33267 | 8001 | 70887147 |
Aphasia | 33.33 | 16.13 | 67 | 33229 | 43182 | 70851966 |
Blood culture positive | 32.24 | 16.13 | 28 | 33268 | 7898 | 70887250 |
Immune thrombocytopenia | 32.14 | 16.13 | 39 | 33257 | 16285 | 70878863 |
Cytomegalovirus enterocolitis | 31.75 | 16.13 | 15 | 33281 | 1468 | 70893680 |
Liver abscess | 31.72 | 16.13 | 24 | 33272 | 5575 | 70889573 |
Leukocytosis | 31.23 | 16.13 | 62 | 33234 | 39606 | 70855542 |
Drug level increased | 31.15 | 16.13 | 59 | 33237 | 36410 | 70858738 |
Feeling abnormal | 30.97 | 16.13 | 14 | 33282 | 142305 | 70752843 |
Glomerulosclerosis | 30.94 | 16.13 | 13 | 33283 | 964 | 70894184 |
Aspergillus infection | 30.89 | 16.13 | 40 | 33256 | 17828 | 70877320 |
Enterococcal bacteraemia | 30.87 | 16.13 | 18 | 33278 | 2708 | 70892440 |
Pulmonary haemorrhage | 30.80 | 16.13 | 35 | 33261 | 13638 | 70881510 |
Sinusitis | 30.54 | 16.13 | 21 | 33275 | 169174 | 70725974 |
Botulism | 30.52 | 16.13 | 10 | 33286 | 367 | 70894781 |
Hepatic function abnormal | 30.21 | 16.13 | 85 | 33211 | 67911 | 70827237 |
Rash morbilliform | 30.06 | 16.13 | 23 | 33273 | 5432 | 70889716 |
Arthritis | 29.93 | 16.13 | 5 | 33291 | 97975 | 70797173 |
Injection site pain | 29.92 | 16.13 | 9 | 33287 | 117610 | 70777538 |
Uraemic encephalopathy | 29.71 | 16.13 | 11 | 33285 | 583 | 70894565 |
Lower respiratory tract infection | 29.51 | 16.13 | 8 | 33288 | 111905 | 70783243 |
Swelling | 29.51 | 16.13 | 27 | 33269 | 188512 | 70706636 |
Rash maculo-papular | 29.49 | 16.13 | 70 | 33226 | 50475 | 70844673 |
Mixed liver injury | 29.39 | 16.13 | 24 | 33272 | 6225 | 70888923 |
Muscle spasms | 29.33 | 16.13 | 18 | 33278 | 154028 | 70741120 |
Hypersensitivity | 29.27 | 16.13 | 39 | 33257 | 229773 | 70665375 |
Enterococcal sepsis | 29.27 | 16.13 | 17 | 33279 | 2540 | 70892608 |
Balance disorder | 28.90 | 16.13 | 4 | 33292 | 90124 | 70805024 |
Discomfort | 28.83 | 16.13 | 7 | 33289 | 105429 | 70789719 |
Tumour lysis syndrome | 28.20 | 16.13 | 42 | 33254 | 21318 | 70873830 |
Cytomegalovirus test positive | 27.70 | 16.13 | 22 | 33274 | 5486 | 70889662 |
Systemic lupus erythematosus | 27.41 | 16.13 | 7 | 33289 | 101895 | 70793253 |
Shock | 26.93 | 16.13 | 59 | 33237 | 40366 | 70854782 |
Intentional product misuse | 26.82 | 16.13 | 3 | 33293 | 79592 | 70815556 |
Enterobacter infection | 26.60 | 16.13 | 19 | 33277 | 4041 | 70891107 |
Acute myeloid leukaemia | 26.35 | 16.13 | 50 | 33246 | 30890 | 70864258 |
Anxiety | 25.49 | 16.13 | 40 | 33256 | 220290 | 70674858 |
Transaminases increased | 25.17 | 16.13 | 63 | 33233 | 46955 | 70848193 |
Nephritis allergic | 25.16 | 16.13 | 10 | 33286 | 643 | 70894505 |
Disseminated mucormycosis | 25.16 | 16.13 | 10 | 33286 | 643 | 70894505 |
Lung infiltration | 25.02 | 16.13 | 40 | 33256 | 21584 | 70873564 |
Encephalitis Japanese B | 24.95 | 16.13 | 6 | 33290 | 68 | 70895080 |
Gastrooesophageal reflux disease | 24.90 | 16.13 | 6 | 33290 | 90833 | 70804315 |
Bacterial toxaemia | 24.69 | 16.13 | 7 | 33289 | 156 | 70894992 |
Drug eruption | 24.46 | 16.13 | 56 | 33240 | 39440 | 70855708 |
Unresponsive to stimuli | 24.14 | 16.13 | 66 | 33230 | 51865 | 70843283 |
Paraesthesia | 23.79 | 16.13 | 20 | 33276 | 145517 | 70749631 |
Device related infection | 23.78 | 16.13 | 49 | 33247 | 32136 | 70863012 |
Back pain | 23.77 | 16.13 | 58 | 33238 | 271094 | 70624054 |
Serum ferritin increased | 23.67 | 16.13 | 25 | 33271 | 8980 | 70886168 |
Disseminated cryptococcosis | 23.47 | 16.13 | 13 | 33283 | 1774 | 70893374 |
Activated partial thromboplastin time prolonged | 22.98 | 16.13 | 30 | 33266 | 13475 | 70881673 |
Contusion | 22.96 | 16.13 | 16 | 33280 | 128020 | 70767128 |
Leukopenia | 22.92 | 16.13 | 105 | 33191 | 106455 | 70788693 |
Corynebacterium infection | 22.89 | 16.13 | 11 | 33285 | 1118 | 70894030 |
Aeromonas infection | 22.81 | 16.13 | 8 | 33288 | 362 | 70894786 |
Pseudomembranous colitis | 22.72 | 16.13 | 19 | 33277 | 5092 | 70890056 |
Burkholderia test positive | 22.70 | 16.13 | 9 | 33287 | 575 | 70894573 |
Graft versus host disease | 21.96 | 16.13 | 31 | 33265 | 14992 | 70880156 |
Venoocclusive liver disease | 21.82 | 16.13 | 26 | 33270 | 10652 | 70884496 |
Systemic mycosis | 21.77 | 16.13 | 14 | 33282 | 2508 | 70892640 |
Engraftment syndrome | 21.71 | 16.13 | 11 | 33285 | 1253 | 70893895 |
Acidosis | 21.43 | 16.13 | 34 | 33262 | 18229 | 70876919 |
Acute lymphocytic leukaemia recurrent | 21.32 | 16.13 | 18 | 33278 | 4886 | 70890262 |
Procalcitonin increased | 21.30 | 16.13 | 14 | 33282 | 2602 | 70892546 |
Small intestinal obstruction | 21.19 | 16.13 | 40 | 33256 | 24615 | 70870533 |
Klebsiella bacteraemia | 21.12 | 16.13 | 14 | 33282 | 2640 | 70892508 |
Chest pain | 21.05 | 16.13 | 55 | 33241 | 251205 | 70643943 |
Blood urea increased | 20.99 | 16.13 | 58 | 33238 | 45851 | 70849297 |
Cerebral aspergillosis | 20.96 | 16.13 | 12 | 33284 | 1744 | 70893404 |
Vanishing bile duct syndrome | 20.96 | 16.13 | 11 | 33285 | 1348 | 70893800 |
Asthenia | 20.67 | 16.13 | 128 | 33168 | 457538 | 70437610 |
Dry mouth | 20.64 | 16.13 | 4 | 33292 | 70453 | 70824695 |
Dyspepsia | 20.60 | 16.13 | 8 | 33288 | 89069 | 70806079 |
Escherichia bacteraemia | 20.45 | 16.13 | 19 | 33277 | 5850 | 70889298 |
Pulseless electrical activity | 20.41 | 16.13 | 28 | 33268 | 13187 | 70881961 |
Blood cholesterol increased | 20.40 | 16.13 | 3 | 33293 | 64601 | 70830547 |
Heparin-induced thrombocytopenia | 20.13 | 16.13 | 23 | 33273 | 9014 | 70886134 |
Osteoarthritis | 20.12 | 16.13 | 5 | 33291 | 74142 | 70821006 |
Clostridial infection | 20.03 | 16.13 | 18 | 33278 | 5311 | 70889837 |
Respiratory alkalosis | 19.95 | 16.13 | 16 | 33280 | 4045 | 70891103 |
Abdominal pain upper | 19.79 | 16.13 | 38 | 33258 | 193564 | 70701584 |
Organising pneumonia | 19.77 | 16.13 | 24 | 33272 | 10026 | 70885122 |
Blastomycosis | 19.76 | 16.13 | 8 | 33288 | 540 | 70894608 |
Vertigo | 19.57 | 16.13 | 3 | 33293 | 62640 | 70832508 |
Mediastinitis | 19.46 | 16.13 | 9 | 33287 | 839 | 70894309 |
Chemotherapeutic drug level increased | 19.37 | 16.13 | 7 | 33289 | 346 | 70894802 |
Choluria | 19.31 | 16.13 | 7 | 33289 | 349 | 70894799 |
Tachypnoea | 19.30 | 16.13 | 42 | 33254 | 28596 | 70866552 |
Chest discomfort | 19.23 | 16.13 | 18 | 33278 | 124363 | 70770785 |
Laryngeal inflammation | 19.07 | 16.13 | 6 | 33290 | 193 | 70894955 |
Loss of personal independence in daily activities | 19.03 | 16.13 | 8 | 33288 | 84902 | 70810246 |
Pericarditis | 18.95 | 16.13 | 8 | 33288 | 84697 | 70810451 |
Product contamination microbial | 18.92 | 16.13 | 9 | 33287 | 895 | 70894253 |
Memory impairment | 18.81 | 16.13 | 10 | 33286 | 92631 | 70802517 |
Cardiac arrest | 18.80 | 16.13 | 134 | 33162 | 159700 | 70735448 |
Cytokine storm | 18.66 | 16.13 | 9 | 33287 | 922 | 70894226 |
Hyperbilirubinaemia | 18.64 | 16.13 | 36 | 33260 | 22532 | 70872616 |
Enterobacter bacteraemia | 18.59 | 16.13 | 8 | 33288 | 629 | 70894519 |
Systemic inflammatory response syndrome | 18.54 | 16.13 | 24 | 33272 | 10688 | 70884460 |
Hypertensive heart disease | 18.33 | 16.13 | 15 | 33281 | 3901 | 70891247 |
Flavobacterium infection | 18.24 | 16.13 | 5 | 33291 | 98 | 70895050 |
Hypervolaemia | 17.99 | 16.13 | 50 | 33246 | 39656 | 70855492 |
Staphylococcal bacteraemia | 17.90 | 16.13 | 24 | 33272 | 11058 | 70884090 |
Injection site erythema | 17.80 | 16.13 | 6 | 33290 | 72918 | 70822230 |
Blood lactate dehydrogenase increased | 17.69 | 16.13 | 46 | 33250 | 35081 | 70860067 |
Hypoalbuminaemia | 17.66 | 16.13 | 32 | 33264 | 19090 | 70876058 |
Pneumonitis | 17.54 | 16.13 | 61 | 33235 | 54536 | 70840612 |
Drug-induced liver injury | 17.43 | 16.13 | 62 | 33234 | 56051 | 70839097 |
Eye infection fungal | 17.31 | 16.13 | 7 | 33289 | 471 | 70894677 |
Inappropriate schedule of product administration | 17.30 | 16.13 | 15 | 33281 | 107540 | 70787608 |
Coagulopathy | 17.22 | 16.13 | 44 | 33252 | 33205 | 70861943 |
Dialysis | 17.20 | 16.13 | 30 | 33266 | 17372 | 70877776 |
Ureaplasma infection | 17.12 | 16.13 | 8 | 33288 | 764 | 70894384 |
COVID-19 pneumonia | 16.88 | 16.13 | 34 | 33262 | 21935 | 70873213 |
Therapeutic product effect incomplete | 16.67 | 16.13 | 19 | 33277 | 119863 | 70775285 |
Hypercapnia | 16.56 | 16.13 | 20 | 33276 | 8309 | 70886839 |
Flushing | 16.49 | 16.13 | 9 | 33287 | 82163 | 70812985 |
Death | 16.28 | 16.13 | 157 | 33139 | 509904 | 70385244 |
Mucosal inflammation | 16.21 | 16.13 | 69 | 33227 | 67781 | 70827367 |
Kidney fibrosis | 16.21 | 16.13 | 13 | 33283 | 3287 | 70891861 |
None
Source | Code | Description |
---|---|---|
ATC | J01DE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Fourth-generation cephalosporins |
ATC | J01RA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
FDA CS | M0003827 | Cephalosporins |
FDA EPC | N0000175488 | Cephalosporin Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Pneumonia due to Pseudomonas | indication | 41381004 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Bacterial peritonitis | indication | 197171003 | |
Pneumococcal pneumonia | indication | 233607000 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
Complicated Proteus UTI | indication | ||
E. Coli Pyelonephritis | indication | ||
Complicated Urinary Tract Infections | indication | ||
Complicated Bacteroides Peritonitis | indication | ||
Complicated Streptococcus Peritonitis | indication | ||
Klebsiella Pyelonephritis | indication | ||
Complicated E. Coli Peritonitis | indication | ||
Enterobacter Pneumonia | indication | ||
Complicated Klebsiella Peritonitis | indication | ||
Proteus Pyelonephritis | indication | ||
Myoclonus | contraindication | 17450006 | |
Colitis | contraindication | 64226004 | DOID:0060180 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Factor II deficiency | contraindication | 73975000 | |
Disorder of brain | contraindication | 81308009 | DOID:936 |
Seizure disorder | contraindication | 128613002 | |
Impaired renal function disorder | contraindication | 197663003 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.32 | acidic |
pKa2 | 13.31 | acidic |
pKa3 | 3.1 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
ID | Source |
---|---|
4024049 | VUID |
N0000022054 | NUI |
D01157 | KEGG_DRUG |
123171-59-5 | SECONDARY_CAS_RN |
20481 | RXNORM |
4020908 | VANDF |
4024049 | VANDF |
C0055003 | UMLSCUI |
CHEBI:478164 | CHEBI |
9WT | PDB_CHEM_ID |
CHEMBL186 | ChEMBL_ID |
CHEMBL1200962 | ChEMBL_ID |
D000077723 | MESH_DESCRIPTOR_UI |
DB01413 | DRUGBANK_ID |
10772 | IUPHAR_LIGAND_ID |
6092 | INN_ID |
807PW4VQE3 | UNII |
5479537 | PUBCHEM_CID |
116681 | MMSL |
4373 | MMSL |
d03882 | MMSL |
004974 | NDDF |
004975 | NDDF |
370370003 | SNOMEDCT_US |
370371004 | SNOMEDCT_US |
96048006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3222 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3223 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-130 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-131 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-240 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-241 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6147 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6147 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6245 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6246 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-326 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |