cefepime 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 535 | 88040-23-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 4 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 85 % | Benet LZ, Broccatelli F, Oprea TI |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.28 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.78 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 18, 1996 | FDA | HOSPIRA INC |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 404.19 | 19.03 | 287 | 15052 | 105258 | 56171470 |
| Encephalopathy | 399.40 | 19.03 | 194 | 15145 | 35131 | 56241597 |
| Acute kidney injury | 304.27 | 19.03 | 350 | 14989 | 240413 | 56036315 |
| Neurotoxicity | 222.32 | 19.03 | 101 | 15238 | 15694 | 56261034 |
| Status epilepticus | 201.11 | 19.03 | 93 | 15246 | 15048 | 56261680 |
| Sepsis | 162.28 | 19.03 | 195 | 15144 | 139645 | 56137083 |
| Drug reaction with eosinophilia and systemic symptoms | 155.44 | 19.03 | 99 | 15240 | 30205 | 56246523 |
| Cytokine release syndrome | 151.30 | 19.03 | 69 | 15270 | 10806 | 56265922 |
| Pyrexia | 141.50 | 19.03 | 335 | 15004 | 418438 | 55858290 |
| Multiple organ dysfunction syndrome | 140.90 | 19.03 | 116 | 15223 | 52654 | 56224074 |
| Myoclonus | 140.74 | 19.03 | 73 | 15266 | 15130 | 56261598 |
| Septic shock | 122.70 | 19.03 | 114 | 15225 | 60721 | 56216007 |
| Thrombocytopenia | 115.81 | 19.03 | 163 | 15176 | 136061 | 56140667 |
| Respiratory failure | 101.14 | 19.03 | 127 | 15212 | 94935 | 56181793 |
| Mental status changes | 99.15 | 19.03 | 82 | 15257 | 37419 | 56239309 |
| Pain | 97.59 | 19.03 | 30 | 15309 | 663154 | 55613574 |
| Toxic encephalopathy | 93.20 | 19.03 | 41 | 15298 | 5897 | 56270831 |
| Acute generalised exanthematous pustulosis | 93.09 | 19.03 | 48 | 15291 | 9821 | 56266907 |
| Tubulointerstitial nephritis | 91.84 | 19.03 | 57 | 15282 | 16608 | 56260120 |
| Pneumonia | 88.33 | 19.03 | 277 | 15062 | 406821 | 55869907 |
| Rheumatoid arthritis | 84.39 | 19.03 | 5 | 15334 | 382599 | 55894129 |
| Arthralgia | 74.94 | 19.03 | 22 | 15317 | 501647 | 55775081 |
| Klebsiella infection | 71.07 | 19.03 | 37 | 15302 | 7719 | 56269009 |
| Clostridium difficile colitis | 69.25 | 19.03 | 50 | 15289 | 18688 | 56258040 |
| Fatigue | 65.93 | 19.03 | 71 | 15268 | 788481 | 55488247 |
| Alopecia | 64.17 | 19.03 | 4 | 15335 | 293454 | 55983274 |
| Neutropenia | 62.52 | 19.03 | 135 | 15204 | 158032 | 56118696 |
| Neutrophil count decreased | 61.81 | 19.03 | 72 | 15267 | 49750 | 56226978 |
| Platelet count decreased | 59.32 | 19.03 | 105 | 15234 | 106278 | 56170450 |
| Pathogen resistance | 58.95 | 19.03 | 30 | 15309 | 5970 | 56270758 |
| Hypoxia | 58.86 | 19.03 | 73 | 15266 | 53824 | 56222904 |
| Bacteraemia | 58.43 | 19.03 | 42 | 15297 | 15589 | 56261139 |
| Abdominal discomfort | 57.14 | 19.03 | 5 | 15334 | 277269 | 55999459 |
| Renal tubular necrosis | 57.04 | 19.03 | 36 | 15303 | 10792 | 56265936 |
| Immune effector cell-associated neurotoxicity syndrome | 56.87 | 19.03 | 20 | 15319 | 1588 | 56275140 |
| Drug resistance | 56.54 | 19.03 | 46 | 15293 | 20496 | 56256232 |
| Mixed liver injury | 48.55 | 19.03 | 23 | 15316 | 3921 | 56272807 |
| Drug intolerance | 46.70 | 19.03 | 8 | 15331 | 264810 | 56011918 |
| Cytomegalovirus test positive | 45.92 | 19.03 | 20 | 15319 | 2806 | 56273922 |
| Acute respiratory distress syndrome | 45.92 | 19.03 | 42 | 15297 | 21884 | 56254844 |
| Nasopharyngitis | 45.47 | 19.03 | 4 | 15335 | 220955 | 56055773 |
| Headache | 44.77 | 19.03 | 52 | 15287 | 558992 | 55717736 |
| Fungaemia | 44.46 | 19.03 | 18 | 15321 | 2106 | 56274622 |
| Aspartate aminotransferase increased | 42.80 | 19.03 | 79 | 15260 | 82523 | 56194205 |
| Malaise | 40.71 | 19.03 | 25 | 15314 | 367835 | 55908893 |
| Hypotension | 40.62 | 19.03 | 155 | 15184 | 250353 | 56026375 |
| Renal impairment | 39.09 | 19.03 | 75 | 15264 | 80638 | 56196090 |
| Shock | 38.60 | 19.03 | 38 | 15301 | 21690 | 56255038 |
| Clostridium difficile infection | 38.31 | 19.03 | 42 | 15297 | 27156 | 56249572 |
| Respiratory distress | 37.99 | 19.03 | 45 | 15294 | 31622 | 56245106 |
| Cholestatic liver injury | 36.80 | 19.03 | 16 | 15323 | 2236 | 56274492 |
| Nephropathy toxic | 36.74 | 19.03 | 25 | 15314 | 8502 | 56268226 |
| Renal failure | 36.60 | 19.03 | 88 | 15251 | 110412 | 56166316 |
| Pancytopenia | 36.47 | 19.03 | 77 | 15262 | 88638 | 56188090 |
| Dizziness | 35.81 | 19.03 | 30 | 15309 | 376110 | 55900618 |
| Enterococcal infection | 35.64 | 19.03 | 23 | 15316 | 7161 | 56269567 |
| Systemic lupus erythematosus | 35.11 | 19.03 | 4 | 15335 | 180074 | 56096654 |
| Therapeutic product effect decreased | 35.03 | 19.03 | 3 | 15336 | 169449 | 56107279 |
| Product dose omission issue | 34.34 | 19.03 | 7 | 15332 | 204746 | 56071982 |
| Antibiotic level above therapeutic | 34.34 | 19.03 | 9 | 15330 | 261 | 56276467 |
| Acute respiratory failure | 33.85 | 19.03 | 42 | 15297 | 30952 | 56245776 |
| Peripheral swelling | 33.69 | 19.03 | 11 | 15328 | 234715 | 56042013 |
| Nephritis allergic | 33.64 | 19.03 | 8 | 15331 | 154 | 56276574 |
| Trichosporon infection | 33.64 | 19.03 | 9 | 15330 | 283 | 56276445 |
| Blood creatinine increased | 33.42 | 19.03 | 70 | 15269 | 80121 | 56196607 |
| Hepatic function abnormal | 33.29 | 19.03 | 44 | 15295 | 34514 | 56242214 |
| Differentiation syndrome | 33.14 | 19.03 | 12 | 15327 | 1037 | 56275691 |
| Swelling | 33.09 | 19.03 | 12 | 15327 | 239759 | 56036969 |
| Confusional state | 33.07 | 19.03 | 128 | 15211 | 208027 | 56068701 |
| Pseudomonas infection | 33.00 | 19.03 | 25 | 15314 | 10046 | 56266682 |
| Rash maculo-papular | 32.91 | 19.03 | 40 | 15299 | 28867 | 56247861 |
| Toxic epidermal necrolysis | 32.72 | 19.03 | 35 | 15304 | 22007 | 56254721 |
| Weight decreased | 31.64 | 19.03 | 13 | 15326 | 240701 | 56036027 |
| Metabolic encephalopathy | 31.48 | 19.03 | 19 | 15320 | 5261 | 56271467 |
| Alanine aminotransferase increased | 31.45 | 19.03 | 75 | 15264 | 93587 | 56183141 |
| Sinusitis | 30.66 | 19.03 | 8 | 15331 | 197573 | 56079155 |
| Anaemia | 30.61 | 19.03 | 149 | 15190 | 267362 | 56009366 |
| Mucormycosis | 30.58 | 19.03 | 15 | 15324 | 2759 | 56273969 |
| Encephalitis Japanese B | 30.42 | 19.03 | 6 | 15333 | 45 | 56276683 |
| Bronchopulmonary aspergillosis | 30.41 | 19.03 | 22 | 15317 | 8242 | 56268486 |
| Enterococcal bacteraemia | 30.27 | 19.03 | 12 | 15327 | 1329 | 56275399 |
| Stenotrophomonas infection | 30.23 | 19.03 | 13 | 15326 | 1768 | 56274960 |
| Agranulocytosis | 30.20 | 19.03 | 34 | 15305 | 22625 | 56254103 |
| Hypertensive heart disease | 29.76 | 19.03 | 14 | 15325 | 2349 | 56274379 |
| Toxic skin eruption | 29.62 | 19.03 | 25 | 15314 | 11714 | 56265014 |
| White blood cell count decreased | 29.26 | 19.03 | 88 | 15251 | 125902 | 56150826 |
| Dysbiosis | 29.02 | 19.03 | 10 | 15329 | 747 | 56275981 |
| Hypersensitivity | 28.93 | 19.03 | 17 | 15322 | 256391 | 56020337 |
| Eosinophilic pneumonia | 28.93 | 19.03 | 13 | 15326 | 1964 | 56274764 |
| Leukocytosis | 28.85 | 19.03 | 34 | 15305 | 23757 | 56252971 |
| Neutropenic colitis | 27.78 | 19.03 | 14 | 15325 | 2729 | 56273999 |
| Klebsiella bacteraemia | 26.09 | 19.03 | 11 | 15328 | 1425 | 56275303 |
| Acute graft versus host disease in skin | 25.73 | 19.03 | 14 | 15325 | 3188 | 56273540 |
| Eosinophilia | 24.86 | 19.03 | 29 | 15310 | 20048 | 56256680 |
| Graft versus host disease | 24.83 | 19.03 | 18 | 15321 | 6763 | 56269965 |
| Musculoskeletal stiffness | 24.81 | 19.03 | 6 | 15333 | 156001 | 56120727 |
| Chemotherapeutic drug level increased | 24.35 | 19.03 | 6 | 15333 | 135 | 56276593 |
| Hyperbilirubinaemia | 24.20 | 19.03 | 21 | 15318 | 10214 | 56266514 |
| Leukopenia | 24.02 | 19.03 | 57 | 15282 | 70883 | 56205845 |
| Metabolic acidosis | 23.91 | 19.03 | 41 | 15298 | 40413 | 56236315 |
| Aphasia | 23.73 | 19.03 | 35 | 15304 | 30380 | 56246348 |
| Staphylococcal infection | 23.39 | 19.03 | 39 | 15300 | 37579 | 56239149 |
| Hyperoxaluria | 23.20 | 19.03 | 6 | 15333 | 165 | 56276563 |
| Engraft failure | 23.07 | 19.03 | 7 | 15332 | 348 | 56276380 |
| Product use issue | 22.94 | 19.03 | 11 | 15328 | 186030 | 56090698 |
| Gait disturbance | 22.82 | 19.03 | 8 | 15331 | 163313 | 56113415 |
| Cholestasis | 22.50 | 19.03 | 32 | 15307 | 26881 | 56249847 |
| Disseminated intravascular coagulation | 22.42 | 19.03 | 26 | 15313 | 17859 | 56258869 |
| Weight increased | 22.22 | 19.03 | 18 | 15321 | 229685 | 56047043 |
| Candida infection | 22.17 | 19.03 | 31 | 15308 | 25636 | 56251092 |
| Cytomegalovirus viraemia | 22.03 | 19.03 | 15 | 15324 | 5105 | 56271623 |
| Fall | 21.92 | 19.03 | 40 | 15299 | 357470 | 55919258 |
| Acute myeloid leukaemia | 21.83 | 19.03 | 25 | 15314 | 16947 | 56259781 |
| Thrombotic microangiopathy | 21.63 | 19.03 | 19 | 15320 | 9392 | 56267336 |
| Hypoaesthesia | 21.43 | 19.03 | 6 | 15333 | 141485 | 56135243 |
| Pseudomembranous colitis | 21.43 | 19.03 | 12 | 15327 | 2891 | 56273837 |
| Blood bilirubin increased | 21.30 | 19.03 | 35 | 15304 | 33319 | 56243409 |
| Delirium | 21.18 | 19.03 | 40 | 15299 | 42477 | 56234251 |
| Vascular device infection | 20.84 | 19.03 | 15 | 15324 | 5575 | 56271153 |
| Asthma | 20.77 | 19.03 | 3 | 15336 | 112767 | 56163961 |
| Ileus | 20.53 | 19.03 | 22 | 15317 | 13860 | 56262868 |
| Enterococcal sepsis | 20.28 | 19.03 | 9 | 15330 | 1321 | 56275407 |
| Respiratory alkalosis | 20.08 | 19.03 | 11 | 15328 | 2540 | 56274188 |
| Pericarditis | 19.83 | 19.03 | 3 | 15336 | 108920 | 56167808 |
| Tonsillitis bacterial | 19.82 | 19.03 | 5 | 15334 | 124 | 56276604 |
| Laryngeal inflammation | 19.53 | 19.03 | 5 | 15334 | 132 | 56276596 |
| Angiokeratoma | 19.38 | 19.03 | 5 | 15334 | 136 | 56276592 |
| Eosinophilic pneumonia acute | 19.22 | 19.03 | 6 | 15333 | 328 | 56276400 |
| Pleural effusion | 19.17 | 19.03 | 59 | 15280 | 85421 | 56191307 |
| Venoocclusive liver disease | 19.13 | 19.03 | 13 | 15326 | 4408 | 56272320 |
| Lower respiratory tract infection | 19.08 | 19.03 | 4 | 15335 | 114790 | 56161938 |
| Electrocardiogram T wave alternans | 19.08 | 19.03 | 4 | 15335 | 42 | 56276686 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 257.45 | 16.13 | 349 | 19670 | 121500 | 31555825 |
| Encephalopathy | 234.30 | 16.13 | 181 | 19838 | 32293 | 31645032 |
| Acute kidney injury | 214.50 | 16.13 | 514 | 19505 | 279200 | 31398125 |
| Cytokine release syndrome | 166.15 | 16.13 | 113 | 19906 | 16529 | 31660796 |
| Neurotoxicity | 161.57 | 16.13 | 110 | 19909 | 16116 | 31661209 |
| Septic shock | 115.01 | 16.13 | 173 | 19846 | 65985 | 31611340 |
| Drug reaction with eosinophilia and systemic symptoms | 106.12 | 16.13 | 112 | 19907 | 29906 | 31647419 |
| Pyrexia | 101.41 | 16.13 | 419 | 19600 | 303421 | 31373904 |
| Multiple organ dysfunction syndrome | 101.40 | 16.13 | 166 | 19853 | 68037 | 31609288 |
| Respiratory failure | 95.66 | 16.13 | 203 | 19816 | 101246 | 31576079 |
| Fatigue | 79.20 | 16.13 | 58 | 19961 | 335148 | 31342177 |
| Acute generalised exanthematous pustulosis | 74.89 | 16.13 | 47 | 19972 | 5993 | 31671332 |
| Renal tubular necrosis | 74.56 | 16.13 | 67 | 19952 | 14692 | 31662633 |
| Sepsis | 73.75 | 16.13 | 237 | 19782 | 151692 | 31525633 |
| Clostridium difficile colitis | 73.36 | 16.13 | 65 | 19954 | 13991 | 31663334 |
| Pathogen resistance | 72.67 | 16.13 | 53 | 19966 | 8648 | 31668677 |
| Hypoxia | 71.43 | 16.13 | 120 | 19899 | 50193 | 31627132 |
| Tubulointerstitial nephritis | 68.90 | 16.13 | 71 | 19948 | 18425 | 31658900 |
| Immune effector cell-associated neurotoxicity syndrome | 66.15 | 16.13 | 32 | 19987 | 2447 | 31674878 |
| Myoclonus | 63.83 | 16.13 | 60 | 19959 | 13930 | 31663395 |
| Neutrophil count decreased | 63.66 | 16.13 | 109 | 19910 | 46285 | 31631040 |
| Mental status changes | 60.93 | 16.13 | 93 | 19926 | 35875 | 31641450 |
| Methaemoglobinaemia | 57.50 | 16.13 | 31 | 19988 | 2975 | 31674350 |
| Dizziness | 55.95 | 16.13 | 28 | 19991 | 199119 | 31478206 |
| Neutropenia | 55.85 | 16.13 | 205 | 19814 | 140159 | 31537166 |
| Enterococcal infection | 55.02 | 16.13 | 45 | 19974 | 8686 | 31668639 |
| Product dose omission issue | 51.53 | 16.13 | 4 | 20015 | 105582 | 31571743 |
| Disseminated intravascular coagulation | 46.47 | 16.13 | 61 | 19958 | 20476 | 31656849 |
| Death | 45.84 | 16.13 | 100 | 19919 | 360469 | 31316856 |
| Bacteraemia | 44.02 | 16.13 | 55 | 19964 | 17579 | 31659746 |
| Brain herniation | 43.36 | 16.13 | 28 | 19991 | 3749 | 31673576 |
| Pseudomonas infection | 42.88 | 16.13 | 44 | 19975 | 11357 | 31665968 |
| Meningitis candida | 42.81 | 16.13 | 10 | 20009 | 71 | 31677254 |
| Septic embolus | 40.84 | 16.13 | 18 | 20001 | 1111 | 31676214 |
| Status epilepticus | 40.68 | 16.13 | 44 | 19975 | 12062 | 31665263 |
| Haemodialysis | 40.03 | 16.13 | 40 | 19979 | 10005 | 31667320 |
| Nephropathy toxic | 39.45 | 16.13 | 42 | 19977 | 11311 | 31666014 |
| Myocardial infarction | 38.30 | 16.13 | 12 | 20007 | 113442 | 31563883 |
| Drug resistance | 37.40 | 16.13 | 59 | 19960 | 23394 | 31653931 |
| Fall | 36.78 | 16.13 | 38 | 19981 | 186051 | 31491274 |
| Bronchopulmonary aspergillosis | 36.41 | 16.13 | 44 | 19975 | 13590 | 31663735 |
| Platelet count decreased | 35.55 | 16.13 | 151 | 19868 | 110284 | 31567041 |
| Thrombocytopenia | 35.51 | 16.13 | 181 | 19838 | 142566 | 31534759 |
| Botulism | 35.45 | 16.13 | 10 | 20009 | 160 | 31677165 |
| Glomerulosclerosis | 34.25 | 16.13 | 14 | 20005 | 716 | 31676609 |
| Acute respiratory distress syndrome | 34.09 | 16.13 | 58 | 19961 | 24482 | 31652843 |
| Blood culture positive | 33.91 | 16.13 | 26 | 19993 | 4572 | 31672753 |
| Arthralgia | 33.36 | 16.13 | 28 | 19991 | 151396 | 31525929 |
| Systemic candida | 32.64 | 16.13 | 22 | 19997 | 3164 | 31674161 |
| Clostridium difficile infection | 32.58 | 16.13 | 47 | 19972 | 17232 | 31660093 |
| White blood cell count decreased | 32.49 | 16.13 | 125 | 19894 | 87273 | 31590052 |
| Confusional state | 32.42 | 16.13 | 168 | 19851 | 133166 | 31544159 |
| Immune thrombocytopenia | 32.32 | 16.13 | 33 | 19986 | 8465 | 31668860 |
| Aspergillus infection | 32.09 | 16.13 | 38 | 19981 | 11490 | 31665835 |
| Antibiotic level above therapeutic | 31.88 | 16.13 | 10 | 20009 | 234 | 31677091 |
| Depression | 31.75 | 16.13 | 9 | 20010 | 90806 | 31586519 |
| Eosinophilia | 31.04 | 16.13 | 54 | 19965 | 23199 | 31654126 |
| Klebsiella infection | 30.96 | 16.13 | 31 | 19988 | 7772 | 31669553 |
| Uraemic encephalopathy | 30.67 | 16.13 | 10 | 20009 | 266 | 31677059 |
| Aspartate aminotransferase increased | 30.47 | 16.13 | 98 | 19921 | 62621 | 31614704 |
| Pain | 29.72 | 16.13 | 45 | 19974 | 186714 | 31490611 |
| Pneumonia | 28.51 | 16.13 | 330 | 19689 | 334982 | 31342343 |
| Cytomegalovirus enterocolitis | 28.32 | 16.13 | 13 | 20006 | 883 | 31676442 |
| Mucormycosis | 27.56 | 16.13 | 25 | 19994 | 5545 | 31671780 |
| Candida infection | 27.46 | 16.13 | 42 | 19977 | 16216 | 31661109 |
| Malaise | 27.39 | 16.13 | 40 | 19979 | 168471 | 31508854 |
| Enterocolitis | 27.22 | 16.13 | 28 | 19991 | 7246 | 31670079 |
| Insomnia | 27.09 | 16.13 | 13 | 20006 | 94823 | 31582502 |
| Burkholderia test positive | 26.69 | 16.13 | 13 | 20006 | 1009 | 31676316 |
| Metabolic encephalopathy | 26.53 | 16.13 | 21 | 19998 | 3868 | 31673457 |
| Gait disturbance | 26.50 | 16.13 | 8 | 20011 | 77487 | 31599838 |
| Weight decreased | 25.97 | 16.13 | 38 | 19981 | 159914 | 31517411 |
| Pneumonia bacterial | 25.51 | 16.13 | 32 | 19987 | 10264 | 31667061 |
| Disseminated mucormycosis | 25.43 | 16.13 | 10 | 20009 | 462 | 31676863 |
| Cytomegalovirus viraemia | 25.37 | 16.13 | 26 | 19993 | 6699 | 31670626 |
| Pleural effusion | 25.30 | 16.13 | 104 | 19915 | 74816 | 31602509 |
| Transaminases increased | 24.37 | 16.13 | 50 | 19969 | 24291 | 31653034 |
| Dyspnoea | 24.36 | 16.13 | 123 | 19896 | 343356 | 31333969 |
| Blood pressure increased | 24.18 | 16.13 | 10 | 20009 | 79623 | 31597702 |
| Respiratory distress | 23.68 | 16.13 | 60 | 19959 | 33493 | 31643832 |
| Rash morbilliform | 23.63 | 16.13 | 17 | 20002 | 2714 | 31674611 |
| Acute myeloid leukaemia recurrent | 23.57 | 16.13 | 15 | 20004 | 1959 | 31675366 |
| Joint swelling | 23.51 | 16.13 | 3 | 20016 | 53428 | 31623897 |
| Alanine aminotransferase increased | 23.16 | 16.13 | 101 | 19918 | 74555 | 31602770 |
| Bacterial toxaemia | 23.08 | 16.13 | 7 | 20012 | 146 | 31677179 |
| Choluria | 22.77 | 16.13 | 7 | 20012 | 153 | 31677172 |
| Aeromonas infection | 22.59 | 16.13 | 8 | 20011 | 275 | 31677050 |
| Cytokine storm | 22.58 | 16.13 | 10 | 20009 | 624 | 31676701 |
| Toxic encephalopathy | 22.50 | 16.13 | 21 | 19998 | 4829 | 31672496 |
| Anxiety | 22.38 | 16.13 | 15 | 20004 | 91018 | 31586307 |
| Inappropriate schedule of product administration | 22.01 | 16.13 | 3 | 20016 | 50820 | 31626505 |
| Trichosporon infection | 21.67 | 16.13 | 10 | 20009 | 687 | 31676638 |
| Corynebacterium infection | 21.19 | 16.13 | 9 | 20010 | 507 | 31676818 |
| Feeling abnormal | 21.15 | 16.13 | 5 | 20014 | 56997 | 31620328 |
| Cholestasis | 21.09 | 16.13 | 48 | 19971 | 25027 | 31652298 |
| Hypersensitivity vasculitis | 20.88 | 16.13 | 17 | 20002 | 3258 | 31674067 |
| Headache | 20.80 | 16.13 | 54 | 19965 | 183598 | 31493727 |
| Blood creatinine increased | 20.77 | 16.13 | 111 | 19908 | 88967 | 31588358 |
| Renal failure | 20.67 | 16.13 | 141 | 19878 | 123189 | 31554136 |
| Toxic epidermal necrolysis | 20.61 | 16.13 | 41 | 19978 | 19483 | 31657842 |
| Drug intolerance | 20.46 | 16.13 | 4 | 20015 | 52029 | 31625296 |
| Kidney fibrosis | 20.26 | 16.13 | 14 | 20005 | 2096 | 31675229 |
| Organising pneumonia | 20.24 | 16.13 | 21 | 19998 | 5489 | 31671836 |
| Cerebral aspergillosis | 20.20 | 16.13 | 12 | 20007 | 1386 | 31675939 |
| Off label use | 20.08 | 16.13 | 319 | 19700 | 346955 | 31330370 |
| Peripheral swelling | 19.84 | 16.13 | 9 | 20010 | 67856 | 31609469 |
| Fungal infection | 19.69 | 16.13 | 34 | 19985 | 14517 | 31662808 |
| Vanishing bile duct syndrome | 19.59 | 16.13 | 9 | 20010 | 612 | 31676713 |
| Hospitalisation | 19.23 | 16.13 | 4 | 20015 | 49803 | 31627522 |
| Asthenia | 19.21 | 16.13 | 75 | 19944 | 224680 | 31452645 |
| Procalcitonin increased | 18.22 | 16.13 | 12 | 20007 | 1661 | 31675664 |
| Haemophagocytic lymphohistiocytosis | 18.09 | 16.13 | 29 | 19990 | 11649 | 31665676 |
| Disseminated cryptococcosis | 17.91 | 16.13 | 11 | 20008 | 1349 | 31675976 |
| Aphasia | 17.71 | 16.13 | 39 | 19980 | 19892 | 31657433 |
| Flavobacterium infection | 17.67 | 16.13 | 5 | 20014 | 81 | 31677244 |
| Sputum culture positive | 17.66 | 16.13 | 12 | 20007 | 1749 | 31675576 |
| Acute respiratory failure | 17.58 | 16.13 | 48 | 19971 | 28007 | 31649318 |
| Retinal ischaemia | 17.57 | 16.13 | 7 | 20012 | 335 | 31676990 |
| Lactobacillus infection | 17.53 | 16.13 | 6 | 20013 | 186 | 31677139 |
| Enterobacter infection | 17.46 | 16.13 | 13 | 20006 | 2187 | 31675138 |
| Drug level increased | 17.37 | 16.13 | 39 | 19980 | 20147 | 31657178 |
| Acute lymphocytic leukaemia recurrent | 17.21 | 16.13 | 15 | 20004 | 3155 | 31674170 |
| Systemic mycosis | 17.20 | 16.13 | 11 | 20008 | 1448 | 31675877 |
| Eye infection fungal | 17.20 | 16.13 | 7 | 20012 | 354 | 31676971 |
| Pancytopenia | 17.18 | 16.13 | 104 | 19915 | 87212 | 31590113 |
| Hepatosplenic candidiasis | 16.84 | 16.13 | 6 | 20013 | 210 | 31677115 |
| Delirium | 16.84 | 16.13 | 61 | 19958 | 41360 | 31635965 |
| Vascular device infection | 16.64 | 16.13 | 15 | 20004 | 3300 | 31674025 |
| Musculoskeletal stiffness | 16.62 | 16.13 | 3 | 20016 | 41322 | 31636003 |
| Dysbiosis | 16.42 | 16.13 | 7 | 20012 | 398 | 31676927 |
| Foetal exposure during pregnancy | 16.37 | 16.13 | 3 | 20016 | 40873 | 31636452 |
| Adenoviral haemorrhagic cystitis | 16.27 | 16.13 | 7 | 20012 | 407 | 31676918 |
| Hypotension | 16.26 | 16.13 | 199 | 19820 | 204419 | 31472906 |
| Hypercapnia | 16.16 | 16.13 | 16 | 20003 | 3955 | 31673370 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Febrile neutropenia | 568.67 | 16.13 | 583 | 32713 | 203735 | 70691413 |
| Encephalopathy | 565.43 | 16.13 | 355 | 32941 | 61306 | 70833842 |
| Acute kidney injury | 470.11 | 16.13 | 815 | 32481 | 473809 | 70421339 |
| Neurotoxicity | 362.43 | 16.13 | 206 | 33090 | 29620 | 70865528 |
| Cytokine release syndrome | 311.36 | 16.13 | 179 | 33117 | 26288 | 70868860 |
| Drug reaction with eosinophilia and systemic symptoms | 234.50 | 16.13 | 204 | 33092 | 57809 | 70837339 |
| Septic shock | 211.55 | 16.13 | 262 | 33034 | 111996 | 70783152 |
| Pyrexia | 205.02 | 16.13 | 687 | 32609 | 606265 | 70288883 |
| Status epilepticus | 201.72 | 16.13 | 132 | 33164 | 24394 | 70870754 |
| Sepsis | 195.56 | 16.13 | 384 | 32912 | 244161 | 70650987 |
| Multiple organ dysfunction syndrome | 189.73 | 16.13 | 244 | 33052 | 108271 | 70786877 |
| Myoclonus | 181.32 | 16.13 | 127 | 33169 | 26228 | 70868920 |
| Respiratory failure | 170.17 | 16.13 | 293 | 33003 | 168442 | 70726706 |
| Mental status changes | 155.21 | 16.13 | 169 | 33127 | 62932 | 70832216 |
| Tubulointerstitial nephritis | 147.26 | 16.13 | 123 | 33173 | 32953 | 70862195 |
| Thrombocytopenia | 141.01 | 16.13 | 332 | 32964 | 238778 | 70656370 |
| Renal tubular necrosis | 135.07 | 16.13 | 101 | 33195 | 23070 | 70872078 |
| Fatigue | 131.12 | 16.13 | 117 | 33179 | 824202 | 70070946 |
| Pain | 128.14 | 16.13 | 68 | 33228 | 628748 | 70266400 |
| Immune effector cell-associated neurotoxicity syndrome | 122.89 | 16.13 | 52 | 33244 | 3926 | 70891222 |
| Neutrophil count decreased | 120.26 | 16.13 | 171 | 33125 | 83385 | 70811763 |
| Hypoxia | 119.84 | 16.13 | 181 | 33115 | 93163 | 70801985 |
| Clostridium difficile colitis | 117.16 | 16.13 | 102 | 33194 | 28894 | 70866254 |
| Rheumatoid arthritis | 115.69 | 16.13 | 5 | 33291 | 291800 | 70603348 |
| Arthralgia | 115.58 | 16.13 | 46 | 33250 | 503344 | 70391804 |
| Pathogen resistance | 112.92 | 16.13 | 73 | 33223 | 13206 | 70881942 |
| Neutropenia | 109.38 | 16.13 | 316 | 32980 | 256840 | 70638308 |
| Acute generalised exanthematous pustulosis | 107.76 | 16.13 | 75 | 33221 | 15322 | 70879826 |
| Platelet count decreased | 101.22 | 16.13 | 244 | 33052 | 177978 | 70717170 |
| Pneumonia | 99.82 | 16.13 | 546 | 32750 | 595686 | 70299462 |
| Joint swelling | 98.22 | 16.13 | 5 | 33291 | 253206 | 70641942 |
| Dizziness | 97.71 | 16.13 | 48 | 33248 | 464093 | 70431055 |
| Drug resistance | 96.88 | 16.13 | 104 | 33192 | 38086 | 70857062 |
| Toxic encephalopathy | 92.92 | 16.13 | 59 | 33237 | 10347 | 70884801 |
| Klebsiella infection | 89.37 | 16.13 | 65 | 33231 | 14227 | 70880921 |
| Enterococcal infection | 85.96 | 16.13 | 64 | 33232 | 14518 | 70880630 |
| Bacteraemia | 83.62 | 16.13 | 85 | 33211 | 29224 | 70865924 |
| Headache | 77.84 | 16.13 | 95 | 33201 | 580310 | 70314838 |
| Product dose omission issue | 76.46 | 16.13 | 7 | 33289 | 217461 | 70677687 |
| Malaise | 74.09 | 16.13 | 57 | 33239 | 432875 | 70462273 |
| Nephropathy toxic | 70.53 | 16.13 | 63 | 33233 | 18451 | 70876697 |
| Drug intolerance | 70.17 | 16.13 | 11 | 33285 | 225676 | 70669472 |
| Acute respiratory distress syndrome | 69.25 | 16.13 | 91 | 33205 | 41163 | 70853985 |
| Disseminated intravascular coagulation | 65.74 | 16.13 | 80 | 33216 | 33518 | 70861630 |
| Alopecia | 65.65 | 16.13 | 8 | 33288 | 198482 | 70696666 |
| Nasopharyngitis | 62.32 | 16.13 | 14 | 33282 | 222192 | 70672956 |
| Pseudomonas infection | 61.44 | 16.13 | 59 | 33237 | 18935 | 70876213 |
| Clostridium difficile infection | 61.13 | 16.13 | 83 | 33213 | 38733 | 70856415 |
| White blood cell count decreased | 60.93 | 16.13 | 197 | 33099 | 169944 | 70725204 |
| Aspartate aminotransferase increased | 60.74 | 16.13 | 163 | 33133 | 126815 | 70768333 |
| Fall | 60.21 | 16.13 | 72 | 33224 | 444024 | 70451124 |
| Peripheral swelling | 58.63 | 16.13 | 19 | 33277 | 236544 | 70658604 |
| Bronchopulmonary aspergillosis | 58.25 | 16.13 | 60 | 33236 | 20942 | 70874206 |
| Arthropathy | 58.04 | 16.13 | 3 | 33293 | 150054 | 70745094 |
| Methaemoglobinaemia | 57.93 | 16.13 | 33 | 33263 | 4753 | 70890395 |
| Confusional state | 57.53 | 16.13 | 275 | 33021 | 284123 | 70611025 |
| Renal failure | 57.26 | 16.13 | 207 | 33089 | 188863 | 70706285 |
| Brain herniation | 56.10 | 16.13 | 37 | 33259 | 6919 | 70888229 |
| Mucormycosis | 55.99 | 16.13 | 39 | 33257 | 7975 | 70887173 |
| Antibiotic level above therapeutic | 55.89 | 16.13 | 18 | 33278 | 625 | 70894523 |
| Blood creatinine increased | 54.32 | 16.13 | 169 | 33127 | 142832 | 70752316 |
| Abdominal discomfort | 53.62 | 16.13 | 17 | 33279 | 214641 | 70680507 |
| Pancytopenia | 53.23 | 16.13 | 174 | 33122 | 150933 | 70744215 |
| Trichosporon infection | 52.53 | 16.13 | 19 | 33277 | 942 | 70894206 |
| Metabolic encephalopathy | 52.20 | 16.13 | 38 | 33258 | 8325 | 70886823 |
| Eosinophilia | 51.44 | 16.13 | 78 | 33218 | 40241 | 70854907 |
| Haemodialysis | 50.69 | 16.13 | 51 | 33245 | 17315 | 70877833 |
| Weight decreased | 50.42 | 16.13 | 43 | 33253 | 310445 | 70584703 |
| Respiratory distress | 47.42 | 16.13 | 89 | 33207 | 54561 | 70840587 |
| Pleural effusion | 46.79 | 16.13 | 153 | 33143 | 132711 | 70762437 |
| Septic embolus | 46.66 | 16.13 | 21 | 33275 | 1839 | 70893309 |
| Gait disturbance | 45.62 | 16.13 | 15 | 33281 | 185091 | 70710057 |
| Toxic epidermal necrolysis | 45.55 | 16.13 | 73 | 33223 | 39484 | 70855664 |
| Dyspnoea | 45.32 | 16.13 | 197 | 33099 | 769863 | 70125285 |
| Alanine aminotransferase increased | 45.08 | 16.13 | 162 | 33134 | 147318 | 70747830 |
| Acute respiratory failure | 43.62 | 16.13 | 85 | 33211 | 53580 | 70841568 |
| Hypotension | 42.61 | 16.13 | 330 | 32966 | 404051 | 70491097 |
| Pain in extremity | 42.53 | 16.13 | 55 | 33241 | 328027 | 70567121 |
| Musculoskeletal stiffness | 42.04 | 16.13 | 9 | 33287 | 147751 | 70747397 |
| Candida infection | 41.60 | 16.13 | 65 | 33231 | 34408 | 70860740 |
| Cholestasis | 41.58 | 16.13 | 78 | 33218 | 47794 | 70847354 |
| Depression | 41.14 | 16.13 | 21 | 33275 | 198953 | 70696195 |
| Fungaemia | 41.14 | 16.13 | 25 | 33271 | 4057 | 70891091 |
| Neutropenic colitis | 40.75 | 16.13 | 27 | 33269 | 5087 | 70890061 |
| Cholestatic liver injury | 40.66 | 16.13 | 25 | 33271 | 4143 | 70891005 |
| Agranulocytosis | 40.55 | 16.13 | 70 | 33226 | 40228 | 70854920 |
| Myocardial infarction | 40.42 | 16.13 | 15 | 33281 | 171630 | 70723518 |
| Meningitis candida | 40.04 | 16.13 | 10 | 33286 | 134 | 70895014 |
| Differentiation syndrome | 39.91 | 16.13 | 20 | 33276 | 2227 | 70892921 |
| Systemic candida | 39.41 | 16.13 | 28 | 33268 | 5906 | 70889242 |
| Enterocolitis | 39.29 | 16.13 | 39 | 33257 | 13027 | 70882121 |
| Cytomegalovirus viraemia | 39.13 | 16.13 | 37 | 33259 | 11648 | 70883500 |
| Blood bilirubin increased | 38.31 | 16.13 | 86 | 33210 | 59815 | 70835333 |
| Insomnia | 38.06 | 16.13 | 28 | 33268 | 217778 | 70677370 |
| Blood pressure increased | 37.36 | 16.13 | 21 | 33275 | 188496 | 70706652 |
| Asthma | 37.27 | 16.13 | 6 | 33290 | 120787 | 70774361 |
| Delirium | 36.89 | 16.13 | 97 | 33199 | 74517 | 70820631 |
| Staphylococcal infection | 35.65 | 16.13 | 78 | 33218 | 53326 | 70841822 |
| Hypoaesthesia | 35.26 | 16.13 | 14 | 33282 | 153725 | 70741423 |
| Renal impairment | 34.93 | 16.13 | 147 | 33149 | 143790 | 70751358 |
| Off label use | 34.89 | 16.13 | 515 | 32781 | 742545 | 70152603 |
| Pneumonia bacterial | 34.80 | 16.13 | 41 | 33255 | 16600 | 70878548 |
| Nausea | 34.77 | 16.13 | 246 | 33050 | 851842 | 70043306 |
| Weight increased | 34.18 | 16.13 | 38 | 33258 | 242293 | 70652855 |
| Haemophagocytic lymphohistiocytosis | 34.05 | 16.13 | 44 | 33252 | 19568 | 70875580 |
| Vascular device infection | 33.95 | 16.13 | 29 | 33267 | 8001 | 70887147 |
| Aphasia | 33.33 | 16.13 | 67 | 33229 | 43182 | 70851966 |
| Blood culture positive | 32.24 | 16.13 | 28 | 33268 | 7898 | 70887250 |
| Immune thrombocytopenia | 32.14 | 16.13 | 39 | 33257 | 16285 | 70878863 |
| Cytomegalovirus enterocolitis | 31.75 | 16.13 | 15 | 33281 | 1468 | 70893680 |
| Liver abscess | 31.72 | 16.13 | 24 | 33272 | 5575 | 70889573 |
| Leukocytosis | 31.23 | 16.13 | 62 | 33234 | 39606 | 70855542 |
| Drug level increased | 31.15 | 16.13 | 59 | 33237 | 36410 | 70858738 |
| Feeling abnormal | 30.97 | 16.13 | 14 | 33282 | 142305 | 70752843 |
| Glomerulosclerosis | 30.94 | 16.13 | 13 | 33283 | 964 | 70894184 |
| Aspergillus infection | 30.89 | 16.13 | 40 | 33256 | 17828 | 70877320 |
| Enterococcal bacteraemia | 30.87 | 16.13 | 18 | 33278 | 2708 | 70892440 |
| Pulmonary haemorrhage | 30.80 | 16.13 | 35 | 33261 | 13638 | 70881510 |
| Sinusitis | 30.54 | 16.13 | 21 | 33275 | 169174 | 70725974 |
| Botulism | 30.52 | 16.13 | 10 | 33286 | 367 | 70894781 |
| Hepatic function abnormal | 30.21 | 16.13 | 85 | 33211 | 67911 | 70827237 |
| Rash morbilliform | 30.06 | 16.13 | 23 | 33273 | 5432 | 70889716 |
| Arthritis | 29.93 | 16.13 | 5 | 33291 | 97975 | 70797173 |
| Injection site pain | 29.92 | 16.13 | 9 | 33287 | 117610 | 70777538 |
| Uraemic encephalopathy | 29.71 | 16.13 | 11 | 33285 | 583 | 70894565 |
| Lower respiratory tract infection | 29.51 | 16.13 | 8 | 33288 | 111905 | 70783243 |
| Swelling | 29.51 | 16.13 | 27 | 33269 | 188512 | 70706636 |
| Rash maculo-papular | 29.49 | 16.13 | 70 | 33226 | 50475 | 70844673 |
| Mixed liver injury | 29.39 | 16.13 | 24 | 33272 | 6225 | 70888923 |
| Muscle spasms | 29.33 | 16.13 | 18 | 33278 | 154028 | 70741120 |
| Hypersensitivity | 29.27 | 16.13 | 39 | 33257 | 229773 | 70665375 |
| Enterococcal sepsis | 29.27 | 16.13 | 17 | 33279 | 2540 | 70892608 |
| Balance disorder | 28.90 | 16.13 | 4 | 33292 | 90124 | 70805024 |
| Discomfort | 28.83 | 16.13 | 7 | 33289 | 105429 | 70789719 |
| Tumour lysis syndrome | 28.20 | 16.13 | 42 | 33254 | 21318 | 70873830 |
| Cytomegalovirus test positive | 27.70 | 16.13 | 22 | 33274 | 5486 | 70889662 |
| Systemic lupus erythematosus | 27.41 | 16.13 | 7 | 33289 | 101895 | 70793253 |
| Shock | 26.93 | 16.13 | 59 | 33237 | 40366 | 70854782 |
| Intentional product misuse | 26.82 | 16.13 | 3 | 33293 | 79592 | 70815556 |
| Enterobacter infection | 26.60 | 16.13 | 19 | 33277 | 4041 | 70891107 |
| Acute myeloid leukaemia | 26.35 | 16.13 | 50 | 33246 | 30890 | 70864258 |
| Anxiety | 25.49 | 16.13 | 40 | 33256 | 220290 | 70674858 |
| Transaminases increased | 25.17 | 16.13 | 63 | 33233 | 46955 | 70848193 |
| Nephritis allergic | 25.16 | 16.13 | 10 | 33286 | 643 | 70894505 |
| Disseminated mucormycosis | 25.16 | 16.13 | 10 | 33286 | 643 | 70894505 |
| Lung infiltration | 25.02 | 16.13 | 40 | 33256 | 21584 | 70873564 |
| Encephalitis Japanese B | 24.95 | 16.13 | 6 | 33290 | 68 | 70895080 |
| Gastrooesophageal reflux disease | 24.90 | 16.13 | 6 | 33290 | 90833 | 70804315 |
| Bacterial toxaemia | 24.69 | 16.13 | 7 | 33289 | 156 | 70894992 |
| Drug eruption | 24.46 | 16.13 | 56 | 33240 | 39440 | 70855708 |
| Unresponsive to stimuli | 24.14 | 16.13 | 66 | 33230 | 51865 | 70843283 |
| Paraesthesia | 23.79 | 16.13 | 20 | 33276 | 145517 | 70749631 |
| Device related infection | 23.78 | 16.13 | 49 | 33247 | 32136 | 70863012 |
| Back pain | 23.77 | 16.13 | 58 | 33238 | 271094 | 70624054 |
| Serum ferritin increased | 23.67 | 16.13 | 25 | 33271 | 8980 | 70886168 |
| Disseminated cryptococcosis | 23.47 | 16.13 | 13 | 33283 | 1774 | 70893374 |
| Activated partial thromboplastin time prolonged | 22.98 | 16.13 | 30 | 33266 | 13475 | 70881673 |
| Contusion | 22.96 | 16.13 | 16 | 33280 | 128020 | 70767128 |
| Leukopenia | 22.92 | 16.13 | 105 | 33191 | 106455 | 70788693 |
| Corynebacterium infection | 22.89 | 16.13 | 11 | 33285 | 1118 | 70894030 |
| Aeromonas infection | 22.81 | 16.13 | 8 | 33288 | 362 | 70894786 |
| Pseudomembranous colitis | 22.72 | 16.13 | 19 | 33277 | 5092 | 70890056 |
| Burkholderia test positive | 22.70 | 16.13 | 9 | 33287 | 575 | 70894573 |
| Graft versus host disease | 21.96 | 16.13 | 31 | 33265 | 14992 | 70880156 |
| Venoocclusive liver disease | 21.82 | 16.13 | 26 | 33270 | 10652 | 70884496 |
| Systemic mycosis | 21.77 | 16.13 | 14 | 33282 | 2508 | 70892640 |
| Engraftment syndrome | 21.71 | 16.13 | 11 | 33285 | 1253 | 70893895 |
| Acidosis | 21.43 | 16.13 | 34 | 33262 | 18229 | 70876919 |
| Acute lymphocytic leukaemia recurrent | 21.32 | 16.13 | 18 | 33278 | 4886 | 70890262 |
| Procalcitonin increased | 21.30 | 16.13 | 14 | 33282 | 2602 | 70892546 |
| Small intestinal obstruction | 21.19 | 16.13 | 40 | 33256 | 24615 | 70870533 |
| Klebsiella bacteraemia | 21.12 | 16.13 | 14 | 33282 | 2640 | 70892508 |
| Chest pain | 21.05 | 16.13 | 55 | 33241 | 251205 | 70643943 |
| Blood urea increased | 20.99 | 16.13 | 58 | 33238 | 45851 | 70849297 |
| Cerebral aspergillosis | 20.96 | 16.13 | 12 | 33284 | 1744 | 70893404 |
| Vanishing bile duct syndrome | 20.96 | 16.13 | 11 | 33285 | 1348 | 70893800 |
| Asthenia | 20.67 | 16.13 | 128 | 33168 | 457538 | 70437610 |
| Dry mouth | 20.64 | 16.13 | 4 | 33292 | 70453 | 70824695 |
| Dyspepsia | 20.60 | 16.13 | 8 | 33288 | 89069 | 70806079 |
| Escherichia bacteraemia | 20.45 | 16.13 | 19 | 33277 | 5850 | 70889298 |
| Pulseless electrical activity | 20.41 | 16.13 | 28 | 33268 | 13187 | 70881961 |
| Blood cholesterol increased | 20.40 | 16.13 | 3 | 33293 | 64601 | 70830547 |
| Heparin-induced thrombocytopenia | 20.13 | 16.13 | 23 | 33273 | 9014 | 70886134 |
| Osteoarthritis | 20.12 | 16.13 | 5 | 33291 | 74142 | 70821006 |
| Clostridial infection | 20.03 | 16.13 | 18 | 33278 | 5311 | 70889837 |
| Respiratory alkalosis | 19.95 | 16.13 | 16 | 33280 | 4045 | 70891103 |
| Abdominal pain upper | 19.79 | 16.13 | 38 | 33258 | 193564 | 70701584 |
| Organising pneumonia | 19.77 | 16.13 | 24 | 33272 | 10026 | 70885122 |
| Blastomycosis | 19.76 | 16.13 | 8 | 33288 | 540 | 70894608 |
| Vertigo | 19.57 | 16.13 | 3 | 33293 | 62640 | 70832508 |
| Mediastinitis | 19.46 | 16.13 | 9 | 33287 | 839 | 70894309 |
| Chemotherapeutic drug level increased | 19.37 | 16.13 | 7 | 33289 | 346 | 70894802 |
| Choluria | 19.31 | 16.13 | 7 | 33289 | 349 | 70894799 |
| Tachypnoea | 19.30 | 16.13 | 42 | 33254 | 28596 | 70866552 |
| Chest discomfort | 19.23 | 16.13 | 18 | 33278 | 124363 | 70770785 |
| Laryngeal inflammation | 19.07 | 16.13 | 6 | 33290 | 193 | 70894955 |
| Loss of personal independence in daily activities | 19.03 | 16.13 | 8 | 33288 | 84902 | 70810246 |
| Pericarditis | 18.95 | 16.13 | 8 | 33288 | 84697 | 70810451 |
| Product contamination microbial | 18.92 | 16.13 | 9 | 33287 | 895 | 70894253 |
| Memory impairment | 18.81 | 16.13 | 10 | 33286 | 92631 | 70802517 |
| Cardiac arrest | 18.80 | 16.13 | 134 | 33162 | 159700 | 70735448 |
| Cytokine storm | 18.66 | 16.13 | 9 | 33287 | 922 | 70894226 |
| Hyperbilirubinaemia | 18.64 | 16.13 | 36 | 33260 | 22532 | 70872616 |
| Enterobacter bacteraemia | 18.59 | 16.13 | 8 | 33288 | 629 | 70894519 |
| Systemic inflammatory response syndrome | 18.54 | 16.13 | 24 | 33272 | 10688 | 70884460 |
| Hypertensive heart disease | 18.33 | 16.13 | 15 | 33281 | 3901 | 70891247 |
| Flavobacterium infection | 18.24 | 16.13 | 5 | 33291 | 98 | 70895050 |
| Hypervolaemia | 17.99 | 16.13 | 50 | 33246 | 39656 | 70855492 |
| Staphylococcal bacteraemia | 17.90 | 16.13 | 24 | 33272 | 11058 | 70884090 |
| Injection site erythema | 17.80 | 16.13 | 6 | 33290 | 72918 | 70822230 |
| Blood lactate dehydrogenase increased | 17.69 | 16.13 | 46 | 33250 | 35081 | 70860067 |
| Hypoalbuminaemia | 17.66 | 16.13 | 32 | 33264 | 19090 | 70876058 |
| Pneumonitis | 17.54 | 16.13 | 61 | 33235 | 54536 | 70840612 |
| Drug-induced liver injury | 17.43 | 16.13 | 62 | 33234 | 56051 | 70839097 |
| Eye infection fungal | 17.31 | 16.13 | 7 | 33289 | 471 | 70894677 |
| Inappropriate schedule of product administration | 17.30 | 16.13 | 15 | 33281 | 107540 | 70787608 |
| Coagulopathy | 17.22 | 16.13 | 44 | 33252 | 33205 | 70861943 |
| Dialysis | 17.20 | 16.13 | 30 | 33266 | 17372 | 70877776 |
| Ureaplasma infection | 17.12 | 16.13 | 8 | 33288 | 764 | 70894384 |
| COVID-19 pneumonia | 16.88 | 16.13 | 34 | 33262 | 21935 | 70873213 |
| Therapeutic product effect incomplete | 16.67 | 16.13 | 19 | 33277 | 119863 | 70775285 |
| Hypercapnia | 16.56 | 16.13 | 20 | 33276 | 8309 | 70886839 |
| Flushing | 16.49 | 16.13 | 9 | 33287 | 82163 | 70812985 |
| Death | 16.28 | 16.13 | 157 | 33139 | 509904 | 70385244 |
| Mucosal inflammation | 16.21 | 16.13 | 69 | 33227 | 67781 | 70827367 |
| Kidney fibrosis | 16.21 | 16.13 | 13 | 33283 | 3287 | 70891861 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01DE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Fourth-generation cephalosporins |
| ATC | J01RA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
| FDA CS | M0003827 | Cephalosporins |
| FDA EPC | N0000175488 | Cephalosporin Antibacterial |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Pneumonia due to Pseudomonas | indication | 41381004 | |
| Bacterial pneumonia | indication | 53084003 | DOID:874 |
| Klebsiella cystitis | indication | 60867007 | |
| Infectious disease of abdomen | indication | 128070006 | |
| Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
| Bacterial peritonitis | indication | 197171003 | |
| Pneumococcal pneumonia | indication | 233607000 | |
| Escherichia coli urinary tract infection | indication | 301011002 | |
| Proteus urinary tract infection | indication | 301012009 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Bacterial urinary infection | indication | 312124009 | |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
| Complicated Proteus UTI | indication | ||
| E. Coli Pyelonephritis | indication | ||
| Complicated Urinary Tract Infections | indication | ||
| Complicated Bacteroides Peritonitis | indication | ||
| Complicated Streptococcus Peritonitis | indication | ||
| Klebsiella Pyelonephritis | indication | ||
| Complicated E. Coli Peritonitis | indication | ||
| Enterobacter Pneumonia | indication | ||
| Complicated Klebsiella Peritonitis | indication | ||
| Proteus Pyelonephritis | indication | ||
| Myoclonus | contraindication | 17450006 | |
| Colitis | contraindication | 64226004 | DOID:0060180 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Factor II deficiency | contraindication | 73975000 | |
| Disorder of brain | contraindication | 81308009 | DOID:936 |
| Seizure disorder | contraindication | 128613002 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.32 | acidic |
| pKa2 | 13.31 | acidic |
| pKa3 | 3.1 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4024049 | VUID |
| N0000022054 | NUI |
| D01157 | KEGG_DRUG |
| 123171-59-5 | SECONDARY_CAS_RN |
| 20481 | RXNORM |
| 4020908 | VANDF |
| 4024049 | VANDF |
| C0055003 | UMLSCUI |
| CHEBI:478164 | CHEBI |
| 9WT | PDB_CHEM_ID |
| CHEMBL186 | ChEMBL_ID |
| CHEMBL1200962 | ChEMBL_ID |
| D000077723 | MESH_DESCRIPTOR_UI |
| DB01413 | DRUGBANK_ID |
| 10772 | IUPHAR_LIGAND_ID |
| 6092 | INN_ID |
| 807PW4VQE3 | UNII |
| 5479537 | PUBCHEM_CID |
| 116681 | MMSL |
| 4373 | MMSL |
| d03882 | MMSL |
| 004974 | NDDF |
| 004975 | NDDF |
| 370370003 | SNOMEDCT_US |
| 370371004 | SNOMEDCT_US |
| 96048006 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3193 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 30 sections |
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
| CEFEPIME HYDROCHLORIDE AND DEXTROSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3195 | INJECTION, SOLUTION | 2 g | INTRAVENOUS | NDA | 30 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-1301 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9566 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-9735 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3222 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3223 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-121 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
| cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-122 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 29 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-130 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-131 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-240 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-241 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 26 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6144 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6145 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6147 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6147 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 28 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6245 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6246 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 27 sections |
| Cefepime | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-326 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |