voriconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 2846 137234-62-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • voriconazole
  • voriconazol
  • vfend
  • UK109496
  • UK-109496
  • UK 109496
A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.
  • Molecular weight: 349.32
  • Formula: C16H14F3N5O
  • CLOGP: 0.79
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 76.72
  • ALOGS: -3.55
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.70 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 34.35 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 96 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.42 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,EIF2AK3,GRK2,PDK1,PDK2,PDK4 7
kinase-selectivity-class GRK2 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.041 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.358 % High 1

Approvals:

DateAgencyCompanyOrphan
May 24, 2002 FDA PF PRISM CV
March 19, 2002 EMA
April 11, 2005 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 741.40 17.44 682 31613 275771 90320381
Mucormycosis 542.91 17.44 147 32148 3674 90592478
Bronchopulmonary aspergillosis 510.79 17.44 181 32114 11217 90584935
Periostitis 507.28 17.44 95 32200 377 90595775
Aspergillus infection 466.56 17.44 167 32128 10656 90585496
Multiple organ dysfunction syndrome 439.01 17.44 284 32011 68052 90528100
Drug ineffective 435.81 17.44 1272 31023 1383026 89213126
Drug resistance 314.54 17.44 172 32123 30277 90565875
Photosensitivity reaction 312.22 17.44 144 32151 17663 90578489
Respiratory failure 300.58 17.44 284 32011 118134 90478018
Drug level increased 287.25 17.44 157 32138 27605 90568547
Hallucination, visual 273.81 17.44 143 32152 22949 90573203
Pneumonia fungal 260.30 17.44 97 32198 6934 90589218
Septic shock 244.97 17.44 218 32077 83942 90512210
Cholestasis 240.70 17.44 154 32141 36145 90560007
Drug level below therapeutic 221.79 17.44 82 32213 5732 90590420
Febrile neutropenia 217.72 17.44 275 32020 158074 90438078
Drug level decreased 193.72 17.44 86 32209 9644 90586508
Acute myeloid leukaemia 176.35 17.44 103 32192 20537 90575615
Squamous cell carcinoma of skin 174.99 17.44 74 32221 7375 90588777
Systemic mycosis 163.05 17.44 47 32248 1483 90594669
Hallucination 163.03 17.44 156 32139 65803 90530349
Fungal infection 162.25 17.44 129 32166 42532 90553620
Graft versus host disease 162.19 17.44 72 32223 8072 90588080
Actinic keratosis 155.70 17.44 54 32241 3134 90593018
Pain 152.57 17.44 83 32212 996258 89599894
Hepatotoxicity 149.98 17.44 127 32168 45715 90550437
Pathogen resistance 143.39 17.44 66 32229 8049 90588103
Cerebral aspergillosis 140.02 17.44 34 32261 541 90595611
Fatigue 136.27 17.44 127 32168 1153896 89442256
Joint swelling 132.66 17.44 13 32282 503287 90092865
Pancytopenia 128.74 17.44 185 32110 120078 90476074
Fusarium infection 123.20 17.44 35 32260 1047 90595105
Sepsis 120.83 17.44 224 32071 179590 90416562
Photodermatosis 118.79 17.44 30 32265 565 90595587
Pulmonary mucormycosis 118.54 17.44 30 32265 570 90595582
Arthropathy 116.44 17.44 3 32292 366239 90229913
Dilatation intrahepatic duct acquired 115.91 17.44 31 32264 737 90595415
Hepatic cytolysis 114.38 17.44 92 32203 30824 90565328
Neurotoxicity 113.18 17.44 79 32216 21388 90574764
Fluorosis 109.64 17.44 22 32273 134 90596018
Rheumatoid arthritis 105.03 17.44 6 32289 362608 90233544
Hepatic function abnormal 98.63 17.44 101 32194 46187 90549965
Swelling 97.87 17.44 16 32279 419042 90177110
Venoocclusive liver disease 97.38 17.44 46 32249 5947 90590205
Fluoride increased 97.06 17.44 15 32280 9 90596143
Abdominal discomfort 95.58 17.44 26 32269 477302 90118850
Cytomegalovirus infection 91.75 17.44 76 32219 26526 90569626
Renal impairment 91.31 17.44 147 32148 105274 90490878
Acute respiratory distress syndrome 90.80 17.44 78 32217 28608 90567544
Gamma-glutamyltransferase increased 88.55 17.44 87 32208 37865 90558287
Synovitis 88.20 17.44 8 32287 329744 90266408
Enterococcal infection 85.70 17.44 50 32245 9941 90586211
Therapeutic product effect decreased 85.57 17.44 3 32292 277568 90318584
Wound 84.79 17.44 6 32289 302974 90293178
Fungaemia 84.45 17.44 35 32260 3315 90592837
Nasopharyngitis 83.72 17.44 21 32274 407083 90189069
Peripheral swelling 83.63 17.44 22 32273 413084 90183068
Brain abscess 83.34 17.44 33 32262 2779 90593373
Skin candida 83.13 17.44 29 32266 1712 90594440
Pruritus 82.80 17.44 45 32250 541480 90054672
Musculoskeletal stiffness 82.61 17.44 6 32289 296526 90299626
Drug ineffective for unapproved indication 82.49 17.44 110 32185 66534 90529618
Scedosporium infection 81.93 17.44 24 32271 802 90595350
Disorganised speech 80.88 17.44 29 32266 1856 90594296
Blood bilirubin increased 78.71 17.44 87 32208 43383 90552769
Infusion related reaction 77.44 17.44 26 32269 416754 90179398
Encephalopathy 77.35 17.44 89 32206 46355 90549797
Acute graft versus host disease 76.85 17.44 38 32257 5430 90590722
Pyrexia 76.43 17.44 448 31847 660037 89936115
Neutropenia 75.62 17.44 213 32082 224691 90371461
Toxoplasmosis 74.85 17.44 27 32268 1758 90594394
Pseudomonas infection 74.40 17.44 53 32242 14812 90581340
Electrocardiogram QT prolonged 73.91 17.44 109 32186 72347 90523805
Systemic lupus erythematosus 71.87 17.44 20 32275 361876 90234276
Arthralgia 71.85 17.44 104 32191 778418 89817734
Immunosuppressant drug level increased 70.19 17.44 34 32261 4646 90591506
Candida infection 70.18 17.44 73 32222 33984 90562168
Disseminated aspergillosis 70.13 17.44 19 32276 475 90595677
Visual impairment 69.71 17.44 149 32146 132216 90463936
Posterior reversible encephalopathy syndrome 69.19 17.44 60 32235 22279 90573873
Polyserositis 68.72 17.44 20 32275 653 90595499
Hypertrophic osteoarthropathy 68.55 17.44 12 32283 29 90596123
Fungal test positive 67.87 17.44 19 32276 538 90595614
Pulmonary alveolar haemorrhage 67.82 17.44 36 32259 5962 90590190
Impaired healing 67.40 17.44 4 32291 234195 90361957
Blood alkaline phosphatase increased 66.75 17.44 84 32211 47995 90548157
Graft versus host disease in gastrointestinal tract 66.18 17.44 32 32263 4356 90591796
Drug hypersensitivity 65.92 17.44 42 32253 463567 90132585
Death 65.10 17.44 328 31967 456223 90139929
Hypersensitivity 64.91 17.44 41 32254 454636 90141516
Mobility decreased 64.63 17.44 7 32288 250727 90345425
Torsade de pointes 64.41 17.44 49 32246 15133 90581019
Acute graft versus host disease in intestine 63.67 17.44 25 32270 2058 90594094
Alopecia 63.62 17.44 50 32245 495021 90101131
Alanine aminotransferase increased 63.22 17.44 134 32161 118204 90477948
Pneumonia bacterial 62.63 17.44 45 32250 12745 90583407
Cytomegalovirus viraemia 62.53 17.44 37 32258 7549 90588603
Solar lentigo 61.56 17.44 21 32274 1159 90594993
Pericarditis 61.52 17.44 11 32284 270140 90326012
Neutrophil count decreased 60.90 17.44 99 32196 71433 90524719
Acute kidney injury 60.40 17.44 250 32045 320137 90276015
Type 2 diabetes mellitus 59.95 17.44 3 32292 203241 90392911
Squamous cell carcinoma 59.94 17.44 40 32255 10061 90586091
Xanthopsia 58.80 17.44 14 32281 204 90595948
Injury 57.93 17.44 3 32292 197346 90398806
Osteoarthritis 57.38 17.44 3 32292 195727 90400425
Corneal perforation 57.25 17.44 17 32278 596 90595556
Geotrichum infection 57.17 17.44 17 32278 599 90595553
Acute myeloid leukaemia recurrent 57.00 17.44 23 32272 2034 90594118
Aspartate aminotransferase increased 56.66 17.44 118 32177 102819 90493333
Thrombotic microangiopathy 56.42 17.44 46 32249 15697 90580455
Gliosis 56.30 17.44 16 32279 479 90595673
Pain in extremity 56.01 17.44 47 32248 450482 90145670
Blood cholesterol increased 55.72 17.44 5 32290 208007 90388145
Pouchitis 55.58 17.44 17 32278 660 90595492
Headache 55.40 17.44 143 32152 862603 89733549
Nervous system disorder 55.08 17.44 52 32243 21541 90574611
Acute graft versus host disease in skin 55.06 17.44 29 32266 4727 90591425
Brain oedema 54.46 17.44 47 32248 17338 90578814
Platelet count decreased 54.36 17.44 138 32157 136831 90459321
Rash 54.20 17.44 128 32167 795972 89800180
Urticaria 53.87 17.44 22 32273 312712 90283440
Bronchial anastomosis complication 53.75 17.44 11 32284 75 90596077
Haemophagocytic lymphohistiocytosis 52.96 17.44 44 32251 15415 90580737
Acute graft versus host disease in liver 52.66 17.44 17 32278 789 90595363
Staphylococcal infection 52.49 17.44 75 32220 48364 90547788
Hypokalaemia 51.93 17.44 132 32163 130984 90465168
Fungal endocarditis 51.56 17.44 14 32281 353 90595799
Malaise 51.36 17.44 81 32214 585905 90010247
Off label use 51.16 17.44 608 31687 1101644 89494508
Pleural effusion 49.93 17.44 118 32177 111873 90484279
Fall 49.87 17.44 59 32236 481751 90114401
Drug level above therapeutic 49.63 17.44 29 32266 5780 90590372
Mucosal inflammation 49.38 17.44 80 32215 57545 90538607
Shock 49.35 17.44 56 32239 28722 90567430
Bone marrow failure 49.09 17.44 59 32236 32162 90563990
Graft versus host disease in skin 48.93 17.44 25 32270 3828 90592324
Systemic candida 48.39 17.44 27 32268 4932 90591220
Intracranial infection 47.97 17.44 12 32283 217 90595935
Weight increased 47.88 17.44 47 32248 417880 90178272
Fibromyalgia 47.83 17.44 8 32287 206261 90389891
Product use in unapproved indication 47.47 17.44 241 32054 335995 90260157
Migraine 47.35 17.44 6 32289 190386 90405766
Pneumonia 46.59 17.44 387 31908 637672 89958480
Necrosis 46.17 17.44 29 32266 6581 90589571
Haemoptysis 45.90 17.44 58 32237 33262 90562890
Exposure during pregnancy 45.79 17.44 14 32281 238396 90357756
Aspergilloma 45.20 17.44 12 32283 277 90595875
Cardiac tamponade 45.20 17.44 27 32268 5605 90590547
Tracheobronchitis 44.88 17.44 18 32277 1567 90594585
Product dose omission issue 44.86 17.44 24 32271 291663 90304489
Strongyloidiasis 44.69 17.44 18 32277 1584 90594568
Chronic graft versus host disease 44.43 17.44 24 32271 4115 90592037
Endophthalmitis 44.34 17.44 25 32270 4660 90591492
Ovarian failure 44.25 17.44 18 32277 1625 90594527
Dizziness 43.96 17.44 90 32205 589194 90006958
Cytokine release syndrome 43.89 17.44 52 32243 27921 90568231
Lentigo 43.70 17.44 14 32281 634 90595518
Altered state of consciousness 43.62 17.44 55 32240 31477 90564675
Disseminated mucormycosis 43.22 17.44 14 32281 657 90595495
Maternal exposure during pregnancy 42.99 17.44 39 32256 360024 90236128
Stenotrophomonas infection 42.90 17.44 20 32275 2509 90593643
Disease progression 42.85 17.44 138 32157 156477 90439675
Liver function test abnormal 42.77 17.44 70 32225 50775 90545377
Contusion 42.73 17.44 18 32277 251198 90344954
Hepatocellular injury 42.44 17.44 52 32243 28906 90567246
Mixed liver injury 42.40 17.44 29 32266 7594 90588558
Chromatopsia 42.40 17.44 13 32282 509 90595643
Sinusitis 42.36 17.44 36 32259 343052 90253100
Abdominal pain upper 42.19 17.44 34 32261 332640 90263512
Drug intolerance 41.98 17.44 59 32236 447532 90148620
Acute lymphocytic leukaemia recurrent 41.51 17.44 20 32275 2701 90593451
Pulmonary haemorrhage 41.09 17.44 29 32266 7984 90588168
Cerebral fungal infection 40.87 17.44 11 32284 268 90595884
Lung transplant rejection 40.87 17.44 15 32280 1026 90595126
Bacterial infection 40.85 17.44 46 32249 23398 90572754
Premature menopause 40.80 17.44 16 32279 1313 90594839
Infective aneurysm 40.27 17.44 12 32283 426 90595726
Immune recovery uveitis 39.97 17.44 8 32287 48 90596104
Renal failure 39.12 17.44 119 32176 130888 90465264
Immunosuppression 38.54 17.44 33 32262 12044 90584108
Psoriasis 38.38 17.44 4 32291 147750 90448402
Chloropsia 38.08 17.44 8 32287 63 90596089
Dyschromatopsia 37.65 17.44 13 32282 744 90595408
Trichosporon infection 37.48 17.44 11 32284 370 90595782
Wheezing 37.48 17.44 19 32276 238061 90358091
Gastrooesophageal reflux disease 37.36 17.44 7 32288 166330 90429822
Disseminated intravascular coagulation 37.08 17.44 42 32253 21496 90574656
Ill-defined disorder 37.08 17.44 10 32285 184881 90411271
Hypomagnesaemia 36.95 17.44 54 32241 35534 90560618
Dry mouth 36.83 17.44 10 32285 184049 90412103
Aspergillus test positive 36.68 17.44 11 32284 399 90595753
Dehiscence 36.39 17.44 9 32286 155 90595997
Fungal skin infection 36.38 17.44 23 32272 5278 90590874
Hypoxia 36.38 17.44 80 32215 72319 90523833
Myoclonus 35.79 17.44 39 32256 19129 90577023
Halo vision 35.75 17.44 11 32284 436 90595716
Tonsillitis bacterial 35.66 17.44 9 32286 169 90595983
Gastrointestinal disorder 35.43 17.44 24 32271 256663 90339489
Toxic encephalopathy 34.55 17.44 27 32268 8672 90587480
Proctectomy 34.23 17.44 9 32286 200 90595952
Pneumothorax 34.06 17.44 38 32257 19129 90577023
Neurological decompensation 33.99 17.44 19 32276 3482 90592670
Nephropathy toxic 33.21 17.44 31 32264 12657 90583495
Chest pain 33.19 17.44 39 32256 319606 90276546
Leukoencephalopathy 33.09 17.44 21 32274 4852 90591300
Anxiety 33.03 17.44 37 32258 309735 90286417
Pericarditis fungal 32.59 17.44 7 32288 62 90596090
Thrombocytopenia 32.56 17.44 154 32141 208571 90387581
Leukaemia recurrent 32.55 17.44 14 32281 1453 90594699
Lower respiratory tract infection 32.55 17.44 25 32270 250634 90345518
Antiphospholipid syndrome 32.54 17.44 16 32279 2258 90593894
Dyspepsia 32.42 17.44 15 32280 198145 90398007
Cortical visual impairment 32.41 17.44 6 32289 22 90596130
Pseudoaldosteronism 32.23 17.44 8 32287 140 90596012
Acute lymphocytic leukaemia 31.93 17.44 17 32278 2831 90593321
Coccidioidomycosis 31.89 17.44 13 32282 1180 90594972
Human herpesvirus 6 infection 31.63 17.44 18 32277 3414 90592738
Rash maculo-papular 31.29 17.44 54 32241 40879 90555273
Granulomatous liver disease 31.17 17.44 12 32283 937 90595215
Graft versus host disease in liver 31.00 17.44 12 32283 951 90595201
Bursitis 30.75 17.44 5 32290 131649 90464503
Dysbiosis 30.56 17.44 14 32281 1688 90594464
Mental status changes 30.38 17.44 56 32239 44623 90551529
Photopsia 30.06 17.44 20 32275 5004 90591148
Imprisonment 29.84 17.44 9 32286 333 90595819
Upper airway necrosis 29.57 17.44 6 32289 39 90596113
Apallic syndrome 29.52 17.44 11 32284 785 90595367
Sleep disorder 29.42 17.44 17 32278 198013 90398139
Rhinocerebral mucormycosis 29.31 17.44 11 32284 801 90595351
Photophobia 29.26 17.44 37 32258 21232 90574920
Hypertransaminasaemia 29.20 17.44 32 32263 15793 90580359
Adenovirus infection 29.12 17.44 19 32276 4603 90591549
Vision blurred 29.09 17.44 96 32199 110197 90485955
Venous thrombosis limb 28.83 17.44 17 32278 3445 90592707
Infection reactivation 28.81 17.44 14 32281 1926 90594226
Fungal sepsis 28.69 17.44 13 32282 1528 90594624
Immunosuppressant drug level decreased 28.68 17.44 12 32283 1164 90594988
Infective pulmonary exacerbation of cystic fibrosis 28.63 17.44 26 32269 10253 90585899
Hyperlactacidaemia 28.52 17.44 18 32277 4118 90592034
Cerebral haemorrhage 28.32 17.44 47 32248 34475 90561677
Cytopenia 28.31 17.44 33 32262 17416 90578736
Dermatitis exfoliative 28.30 17.44 20 32275 5516 90590636
Peritonitis 28.26 17.44 35 32260 19670 90576482
Infection in an immunocompromised host 28.14 17.44 11 32284 895 90595257
Muscle spasms 28.05 17.44 29 32266 251854 90344298
Bacteraemia 27.87 17.44 37 32258 22263 90573889
Blood lactate dehydrogenase increased 27.87 17.44 40 32255 25892 90570260
Blister 27.68 17.44 30 32265 254968 90341184
Gait inability 27.40 17.44 9 32286 146447 90449705
Neck pain 27.36 17.44 4 32291 113959 90482193
Lower respiratory tract infection fungal 27.35 17.44 8 32287 266 90595886
Necrotising colitis 27.19 17.44 12 32283 1326 90594826
Stomatitis 26.95 17.44 35 32260 274663 90321489
Hypoaesthesia 26.94 17.44 44 32251 314166 90281986
Drug-induced liver injury 26.91 17.44 82 32213 90236 90505916
Dermatitis bullous 26.61 17.44 25 32270 10291 90585861
Somatic symptom disorder 26.33 17.44 16 32279 3425 90592727
Septal panniculitis 26.05 17.44 6 32289 75 90596077
Primary myelofibrosis 26.05 17.44 6 32289 75 90596077
Respirovirus test positive 25.92 17.44 5 32290 24 90596128
Hallucination, auditory 25.56 17.44 30 32265 15945 90580207
Colour blindness 25.55 17.44 8 32287 336 90595816
Acinetobacter infection 25.41 17.44 13 32282 1995 90594157
Procalcitonin increased 25.39 17.44 12 32283 1552 90594600
Pneumomediastinum 25.27 17.44 13 32282 2018 90594134
Mycotic endophthalmitis 25.25 17.44 7 32288 191 90595961
Aspergillus test 25.13 17.44 5 32290 29 90596123
Functional residual capacity increased 24.85 17.44 6 32289 93 90596059
Anal infection 24.85 17.44 6 32289 93 90596059
Pseudomonas test positive 24.55 17.44 10 32285 906 90595246
Cachexia 24.44 17.44 20 32275 6858 90589294
Adverse drug reaction 23.99 17.44 6 32289 116695 90479457
Feeling abnormal 23.93 17.44 15 32280 167220 90428932
Insomnia 23.93 17.44 52 32243 333422 90262730
Traumatic haemothorax 23.61 17.44 7 32288 244 90595908
Depressed level of consciousness 23.51 17.44 68 32227 72716 90523436
Paraesthesia 23.44 17.44 33 32262 250293 90345859
Lung infiltration 23.30 17.44 28 32267 15254 90580898
Bacterial sepsis 23.27 17.44 17 32278 4938 90591214
Lip dry 23.21 17.44 4 32291 100951 90495201
Leukaemia 23.16 17.44 17 32278 4975 90591177
Diarrhoea 23.01 17.44 219 32076 938971 89657181
Mycobacterium abscessus infection 23.01 17.44 10 32285 1065 90595087
Venoocclusive disease 22.96 17.44 13 32282 2442 90593710
Phaeohyphomycosis 22.89 17.44 8 32287 475 90595677
Weight decreased 22.77 17.44 65 32230 379845 90216307
Blood pressure increased 22.76 17.44 22 32273 197195 90398957
Agranulocytosis 22.71 17.44 43 32252 34959 90561193
Skin cancer 22.66 17.44 26 32269 13493 90582659
Fungal disease carrier 22.55 17.44 5 32290 52 90596100
Toxic epidermal necrolysis 22.40 17.44 41 32254 32487 90563665
Adverse event 22.34 17.44 7 32288 117411 90478741
Hypophosphataemia 22.30 17.44 27 32268 14827 90581325
Ileostomy closure 22.29 17.44 7 32288 297 90595855
Central nervous system fungal infection 22.26 17.44 6 32289 147 90596005
Cytomegalovirus infection reactivation 22.25 17.44 20 32275 7780 90588372
Cardiac arrest 22.23 17.44 85 32210 104850 90491302
Chronic papillomatous dermatitis 22.21 17.44 5 32290 56 90596096
Post transplant lymphoproliferative disorder 22.20 17.44 19 32276 6930 90589222
Hepatic enzyme increased 22.15 17.44 61 32234 360675 90235477
Scintillating scotoma 22.15 17.44 6 32289 150 90596002
Gastrointestinal polyp 22.03 17.44 6 32289 153 90595999
Eye abscess 21.92 17.44 6 32289 156 90595996
Obliterative bronchiolitis 21.90 17.44 13 32282 2668 90593484
Graft versus host disease in lung 21.87 17.44 8 32287 542 90595610
Osteoporosis 21.81 17.44 4 32291 96527 90499625
Blood beta-D-glucan increased 21.77 17.44 7 32288 321 90595831
Asthma 21.62 17.44 33 32262 242127 90354025
Capillary leak syndrome 21.52 17.44 13 32282 2754 90593398
Hypertension 21.49 17.44 87 32208 457445 90138707
Klebsiella infection 21.08 17.44 22 32273 10275 90585877
Cholecystitis acute 20.90 17.44 21 32274 9383 90586769
Ocular surface squamous neoplasia 20.82 17.44 3 32292 0 90596152
Erythropsia 20.82 17.44 3 32292 0 90596152
Cytomegalovirus test positive 20.78 17.44 14 32281 3577 90592575
Inappropriate schedule of product administration 20.70 17.44 14 32281 149919 90446233
Respiratory distress 20.66 17.44 44 32251 38902 90557250
Hepatic artery aneurysm 20.60 17.44 4 32291 20 90596132
Septic embolus 20.45 17.44 9 32286 988 90595164
Keratitis fungal 20.41 17.44 6 32289 203 90595949
Tuberculosis gastrointestinal 20.30 17.44 7 32288 399 90595753
Delirium 20.06 17.44 82 32213 104277 90491875
Back pain 19.94 17.44 53 32242 317122 90279030
Palpitations 19.93 17.44 12 32283 136716 90459436
Intentional product use issue 19.90 17.44 29 32266 216863 90379289
Musculoskeletal pain 19.88 17.44 19 32276 171232 90424920
Hepatic candidiasis 19.85 17.44 4 32291 25 90596127
Torticollis 19.84 17.44 12 32283 2546 90593606
Nocardiosis 19.79 17.44 12 32283 2558 90593594
Loss of personal independence in daily activities 19.76 17.44 12 32283 136093 90460059
Amnesia 19.72 17.44 7 32288 108498 90487654
Tumour lysis syndrome 19.63 17.44 22 32273 11130 90585022
Drug abuse 19.51 17.44 3 32292 82344 90513808
Myoglobin blood increased 19.50 17.44 10 32285 1542 90594610
Memory impairment 19.48 17.44 25 32270 197219 90398933
Pulmonary fibrosis 19.43 17.44 7 32288 107496 90488656
Wound infection 19.10 17.44 7 32288 106395 90489757
Upper respiratory tract infection 19.07 17.44 11 32284 128307 90467845
Stem cell transplant 19.06 17.44 11 32284 2143 90594009
Neutropenic colitis 18.97 17.44 14 32281 4129 90592023
Mental disorder 18.89 17.44 38 32257 32280 90563872
Brain herniation 18.80 17.44 14 32281 4186 90591966
Cross sensitivity reaction 18.62 17.44 12 32283 2845 90593307
Babesiosis 18.58 17.44 6 32289 279 90595873
Chronic graft versus host disease in skin 18.57 17.44 9 32286 1231 90594921
Respiratory tract infection fungal 18.53 17.44 7 32288 519 90595633
Leukopenia 18.47 17.44 78 32217 100632 90495520
Cytomegalovirus enterocolitis 18.28 17.44 8 32287 866 90595286
Sputum increased 18.25 17.44 12 32283 2945 90593207
Central nervous system infection 18.22 17.44 8 32287 873 90595279
Aplastic anaemia 18.12 17.44 23 32272 13246 90582906
Laryngeal inflammation 18.05 17.44 5 32290 136 90596016
Renal aneurysm 18.01 17.44 4 32291 42 90596110
Encephalitis 17.97 17.44 21 32274 11113 90585039
Haemothorax 17.88 17.44 11 32284 2407 90593745
Cytomegalovirus chorioretinitis 17.87 17.44 11 32284 2408 90593744
Acute respiratory failure 17.80 17.44 44 32251 42874 90553278
Herpes simplex 17.77 17.44 20 32275 10161 90585991
Hepatosplenic candidiasis 17.68 17.44 6 32289 326 90595826
Hyperkalaemia 17.53 17.44 57 32238 64907 90531245
Osteomyelitis fungal 17.52 17.44 4 32291 48 90596104
Cystitis haemorrhagic 17.46 17.44 15 32280 5498 90590654
Red blood cell sedimentation rate increased 17.46 17.44 4 32291 82591 90513561

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 845.94 13.79 2058 46506 628139 41944632
Photosensitivity reaction 790.20 13.79 353 48211 12349 42560422
Drug interaction 746.87 13.79 1191 47373 265808 42306963
Bronchopulmonary aspergillosis 672.89 13.79 362 48202 19067 42553704
Aspergillus infection 659.78 13.79 334 48230 15503 42557268
Drug level increased 500.95 13.79 333 48231 25867 42546904
Periostitis 436.14 13.79 97 48467 254 42572517
Mucormycosis 417.05 13.79 190 48374 6953 42565818
Actinic keratosis 414.33 13.79 172 48392 5004 42567767
Hallucination, visual 391.73 13.79 263 48301 20757 42552014
Drug resistance 351.61 13.79 300 48264 33948 42538823
Cerebral aspergillosis 335.60 13.79 111 48453 1666 42571105
Squamous cell carcinoma of skin 334.44 13.79 198 48366 12528 42560243
Hallucination 297.76 13.79 347 48217 57160 42515611
Multiple organ dysfunction syndrome 265.64 13.79 430 48134 96605 42476166
Hepatotoxicity 265.52 13.79 224 48340 24943 42547828
Fungal infection 225.63 13.79 184 48380 19538 42553233
Pathogen resistance 203.08 13.79 139 48425 11311 42561460
Scedosporium infection 192.73 13.79 71 48493 1487 42571284
Pneumonia fungal 186.23 13.79 121 48443 9025 42563746
Fatigue 180.50 13.79 140 48424 435501 42137270
Septic shock 177.08 13.79 349 48215 91323 42481448
Photodermatosis 174.21 13.79 55 48509 705 42572066
Respiratory failure 158 13.79 408 48156 127724 42445047
Graft versus host disease 157.18 13.79 125 48439 12800 42559971
Squamous cell carcinoma 154.56 13.79 124 48440 12858 42559913
Systemic mycosis 153.65 13.79 68 48496 2319 42570452
Choroiditis 153.06 13.79 58 48506 1317 42571454
Disorganised speech 143.82 13.79 56 48508 1372 42571399
Hepatic function abnormal 133.46 13.79 223 48341 51344 42521427
Drug level below therapeutic 124.51 13.79 83 48481 6462 42566309
Product dose omission issue 119.43 13.79 17 48547 154348 42418423
Solar lentigo 117.30 13.79 39 48525 595 42572176
Fusarium infection 116.94 13.79 50 48514 1566 42571205
Drug ineffective for unapproved indication 115.95 13.79 197 48367 45966 42526805
Condition aggravated 114.14 13.79 592 47972 260162 42312609
Cholestasis 112.83 13.79 162 48402 32717 42540054
Visual impairment 110.96 13.79 186 48378 42927 42529844
Drug level decreased 109.72 13.79 91 48473 9886 42562885
Febrile neutropenia 107.89 13.79 458 48106 185245 42387526
Pain 105.89 13.79 75 48489 244773 42327998
Dysplastic naevus 102.57 13.79 36 48528 652 42572119
Drug abuse 101.93 13.79 4 48560 104767 42468004
Acute myeloid leukaemia 98.27 13.79 124 48440 22132 42550639
Completed suicide 96.23 13.79 3 48561 96462 42476309
Fall 94.79 13.79 77 48487 234443 42338328
Aspergilloma 92.27 13.79 30 48534 425 42572346
Fluoride increased 91.75 13.79 20 48544 46 42572725
Cheilitis 91.33 13.79 49 48515 2559 42570212
Immunosuppressant drug level increased 90.22 13.79 73 48491 7658 42565113
Nephropathy toxic 89.36 13.79 103 48461 16735 42556036
Candida infection 88.50 13.79 116 48448 21494 42551277
Fungaemia 88.17 13.79 51 48513 3085 42569686
Brain abscess 88.00 13.79 57 48507 4227 42568544
Disseminated mucormycosis 87.52 13.79 39 48525 1352 42571419
Pruritus 85.35 13.79 55 48509 188716 42384055
Neurotoxicity 80.35 13.79 116 48448 23535 42549236
Pulmonary mucormycosis 79.57 13.79 37 48527 1418 42571353
Asthenia 77.86 13.79 125 48439 280668 42292103
Treatment failure 77.66 13.79 200 48364 62424 42510347
Fluorosis 76.02 13.79 17 48547 46 42572725
Aspergillus test positive 75.98 13.79 29 48535 672 42572099
Drug level above therapeutic 75.85 13.79 59 48505 5847 42566924
Drug-induced liver injury 75.35 13.79 147 48417 38126 42534645
Pseudomonas infection 73.94 13.79 91 48473 15832 42556939
Arthralgia 73.82 13.79 75 48489 205163 42367608
Depression 71.93 13.79 19 48545 111344 42461427
Visual acuity reduced 71.54 13.79 94 48470 17456 42555315
Myocardial infarction 71.42 13.79 26 48538 123983 42448788
Dyspnoea 68.75 13.79 266 48298 442355 42130416
Fungal endocarditis 68.10 13.79 24 48540 440 42572331
Anxiety 68.04 13.79 25 48539 118535 42454236
Dyschromatopsia 67.83 13.79 25 48539 524 42572247
Intraocular pressure increased 67.27 13.79 57 48507 6376 42566395
Constipation 67.13 13.79 52 48512 162239 42410532
Lip squamous cell carcinoma 65.65 13.79 18 48546 135 42572636
Acute myeloid leukaemia recurrent 65.51 13.79 44 48520 3468 42569303
Off label use 65.44 13.79 1054 47510 637281 41935490
Graft versus host disease in gastrointestinal tract 65.23 13.79 51 48513 5092 42567679
Nausea 63.84 13.79 235 48329 396564 42176207
Pain in extremity 62.61 13.79 48 48516 150556 42422215
Delirium 62.31 13.79 165 48399 52354 42520417
Xanthopsia 59.87 13.79 17 48547 147 42572624
Blood pressure increased 57.63 13.79 22 48542 101906 42470865
Diarrhoea 56.57 13.79 302 48262 460547 42112224
Toxic optic neuropathy 55.49 13.79 26 48538 1014 42571757
Hepatocellular injury 55.44 13.79 98 48466 23580 42549191
Nasopharyngitis 54.87 13.79 14 48550 83982 42488789
Dizziness 54.25 13.79 128 48436 249126 42323645
Back pain 54.22 13.79 49 48515 141727 42431044
Inappropriate schedule of product administration 53.72 13.79 21 48543 95881 42476890
Hepatitis cholestatic 53.65 13.79 61 48503 9763 42563008
Mental disorder 53.48 13.79 83 48481 17946 42554825
Uveitis 53.14 13.79 59 48505 9199 42563572
Dehydration 53.03 13.79 50 48514 141717 42431054
Enterococcal infection 53.01 13.79 67 48497 11972 42560799
Acute graft versus host disease in skin 52.74 13.79 53 48511 7371 42565400
Chloropsia 52.49 13.79 10 48554 7 42572764
Mediastinitis 52.31 13.79 25 48539 1020 42571751
Phaeohyphomycosis 52.28 13.79 26 48538 1158 42571613
Disseminated intravascular coagulation 52.20 13.79 98 48466 24696 42548075
Hypertension 51.59 13.79 69 48495 167135 42405636
Disseminated aspergillosis 50.95 13.79 29 48535 1701 42571070
Blood alkaline phosphatase increased 50.94 13.79 116 48448 33481 42539290
Pancytopenia 50.41 13.79 266 48298 117477 42455294
Malaise 48.54 13.79 106 48458 212050 42360721
Injection site pain 48.01 13.79 5 48559 57793 42514978
Eye pain 47.20 13.79 76 48488 16954 42555817
Weight decreased 46.67 13.79 105 48459 207843 42364928
Headache 45.89 13.79 131 48433 239238 42333533
Alternaria infection 44.62 13.79 19 48545 589 42572182
Peripheral swelling 43.99 13.79 24 48540 90246 42482525
Intentional overdose 43.92 13.79 4 48560 51452 42521319
Leukaemia recurrent 43.62 13.79 27 48537 1849 42570922
Asthma 43.45 13.79 9 48555 62305 42510466
Sinusitis fungal 43.39 13.79 20 48544 751 42572020
Osteomyelitis fungal 43.34 13.79 16 48548 337 42572434
Cytomegalovirus viraemia 42.94 13.79 56 48508 10321 42562450
Cardiac failure congestive 42.83 13.79 22 48542 85580 42487191
Hyperhidrosis 42.77 13.79 25 48539 90487 42482284
Endophthalmitis 41.74 13.79 37 48527 4396 42568375
Product compounding quality issue 41.50 13.79 9 48555 20 42572751
Enterococcal sepsis 41.50 13.79 27 48537 2017 42570754
Renal abscess 41.39 13.79 16 48548 384 42572387
Musculoskeletal stiffness 40.99 13.79 8 48556 57757 42515014
Cytomegalovirus infection 40.87 13.79 104 48460 32202 42540569
Inappropriate antidiuretic hormone secretion 40.72 13.79 70 48494 16471 42556300
Chest pain 40.62 13.79 60 48504 139470 42433301
Urticaria 40.17 13.79 17 48547 74019 42498752
Abscess fungal 40.06 13.79 15 48549 329 42572442
Septic embolus 39.90 13.79 23 48541 1382 42571389
Loss of personal independence in daily activities 39.64 13.79 5 48559 49811 42522960
Prostate cancer 39.40 13.79 3 48561 44640 42528131
Acute respiratory distress syndrome 39.21 13.79 98 48466 30010 42542761
Photophobia 38.66 13.79 47 48517 8072 42564699
Gamma-glutamyltransferase increased 38.43 13.79 102 48462 32395 42540376
Dysphoria 38.39 13.79 29 48535 2751 42570020
Pulmonary embolism 38.28 13.79 48 48516 119564 42453207
Acute graft versus host disease 38.22 13.79 47 48517 8168 42564603
Pseudoporphyria 38.12 13.79 16 48548 478 42572293
Muscle spasms 37.59 13.79 26 48538 86018 42486753
Cystitis haemorrhagic 37.48 13.79 44 48520 7285 42565486
Rectal haemorrhage 37.09 13.79 6 48558 49600 42523171
Stenotrophomonas infection 37.05 13.79 32 48532 3672 42569099
Foetal exposure during pregnancy 37.04 13.79 5 48559 47306 42525465
Gallbladder oedema 36.86 13.79 13 48551 239 42572532
Human polyomavirus infection 36.12 13.79 21 48543 1282 42571489
Hepatic cytolysis 35.62 13.79 88 48476 26756 42546015
Intentional product misuse 35.58 13.79 13 48551 61887 42510884
Dyspnoea exertional 35.47 13.79 7 48557 50141 42522630
Photopsia 35.37 13.79 26 48538 2366 42570405
Halo vision 35.33 13.79 12 48552 196 42572575
Acute graft versus host disease in intestine 35.27 13.79 32 48532 3919 42568852
Graft versus host disease in skin 34.82 13.79 36 48528 5176 42567595
Joint swelling 34.75 13.79 17 48547 68005 42504766
Mycobacterium avium complex infection 34.09 13.79 28 48536 2999 42569772
Product use issue 33.93 13.79 175 48389 76576 42496195
Psoriasis 33.93 13.79 7 48557 48597 42524174
Pneumonia necrotising 33.88 13.79 19 48545 1083 42571688
Central nervous system lesion 33.39 13.79 43 48521 7827 42564944
Blood bilirubin increased 33.33 13.79 115 48449 42137 42530634
Dyspepsia 33.27 13.79 4 48560 41348 42531423
Nocardiosis 33.16 13.79 35 48529 5155 42567616
Hallucinations, mixed 33 13.79 29 48535 3406 42569365
Hepatic failure 32.98 13.79 107 48457 37993 42534778
Acute graft versus host disease in liver 32.90 13.79 23 48541 1935 42570836
Infectious pleural effusion 32.77 13.79 28 48536 3167 42569604
Altered state of consciousness 32.75 13.79 90 48474 29169 42543602
Pyrexia 32.73 13.79 630 47934 393412 42179359
Central nervous system fungal infection 32.72 13.79 14 48550 439 42572332
BK virus infection 32.67 13.79 45 48519 8739 42564032
Gastrooesophageal reflux disease 32.45 13.79 6 48558 45017 42527754
Liver injury 32.29 13.79 69 48495 19079 42553692
Lung abscess 32.26 13.79 28 48536 3235 42569536
Vomiting 32.12 13.79 196 48368 289527 42283244
Cerebral fungal infection 31.83 13.79 13 48551 362 42572409
Hospitalisation 31.75 13.79 23 48541 74307 42498464
Product contamination microbial 31.73 13.79 16 48548 734 42572037
Drug hypersensitivity 31.67 13.79 40 48524 99349 42473422
Liver disorder 31.35 13.79 108 48456 39536 42533235
Haemophagocytic lymphohistiocytosis 31.11 13.79 66 48498 18156 42554615
Chromatopsia 30.97 13.79 12 48552 290 42572481
Enterococcal bacteraemia 30.73 13.79 25 48539 2642 42570129
Klebsiella infection 30.62 13.79 50 48514 11282 42561489
Torsade de pointes 30.43 13.79 43 48521 8551 42564220
Pulmonary mass 30.22 13.79 61 48503 16204 42556567
Malignant neoplasm progression 30.21 13.79 48 48516 108352 42464419
Mycotic endophthalmitis 30.09 13.79 11 48553 225 42572546
Post transplant lymphoproliferative disorder 29.90 13.79 44 48520 9076 42563695
Rheumatoid arthritis 29.86 13.79 6 48558 42434 42530337
Abdominal pain 29.74 13.79 114 48450 190357 42382414
Arthritis fungal 29.43 13.79 9 48555 103 42572668
Swelling 29.14 13.79 13 48551 54872 42517899
Chronic obstructive pulmonary disease 29.01 13.79 18 48546 63096 42509675
Neutropenia 29.01 13.79 351 48213 199080 42373691
Macular opacity 28.89 13.79 5 48559 0 42572771
Lower respiratory tract infection fungal 28.80 13.79 14 48550 593 42572178
Syncope 28.67 13.79 43 48521 99363 42473408
Venoocclusive liver disease 28.58 13.79 46 48518 10256 42562515
Eye infection fungal 28.56 13.79 13 48551 474 42572297
Neurological symptom 28.25 13.79 45 48519 9946 42562825
Microangiopathic haemolytic anaemia 27.92 13.79 17 48547 1130 42571641
Toxic skin eruption 27.33 13.79 53 48511 13677 42559094
Chronic graft versus host disease 27.27 13.79 34 48530 5991 42566780
Hypertrophic osteoarthropathy 26.96 13.79 8 48556 82 42572689
Tongue necrosis 26.74 13.79 7 48557 43 42572728
Pulmonary haemorrhage 26.45 13.79 47 48517 11350 42561421
Brain herniation 26.42 13.79 30 48534 4793 42567978
Dry skin 26.38 13.79 11 48553 48327 42524444
Renal impairment 26.26 13.79 215 48349 110013 42462758
Scopulariopsis infection 26.17 13.79 9 48555 153 42572618
Wrong technique in product usage process 26.17 13.79 8 48556 42627 42530144
Urinary tract inflammation 25.95 13.79 10 48554 238 42572533
Pulmonary cavitation 25.92 13.79 17 48547 1287 42571484
Gait disturbance 25.81 13.79 45 48519 97955 42474816
Eczema 25.76 13.79 4 48560 34082 42538689
Pneumonia 25.51 13.79 645 47919 421504 42151267
Trichosporon infection 25.49 13.79 15 48549 937 42571834
Lung infiltration 25.44 13.79 52 48512 13937 42558834
Dry mouth 25.36 13.79 7 48557 39872 42532899
Cerebrovascular accident 25.24 13.79 45 48519 97115 42475656
Ectropion 25.09 13.79 9 48555 174 42572597
Somnolence 25.01 13.79 80 48484 141025 42431746
Product use in unapproved indication 24.82 13.79 320 48244 184136 42388635
Transmission of an infectious agent via product 24.76 13.79 9 48555 181 42572590
Pneumonia bacterial 24.70 13.79 55 48509 15637 42557134
Sleep disorder 24.59 13.79 12 48552 48083 42524688
Angina pectoris 24.54 13.79 4 48560 32892 42539879
Deep vein thrombosis 24.49 13.79 31 48533 76926 42495845
Necrotising retinitis 24.40 13.79 15 48549 1015 42571756
Renal ischaemia 24.35 13.79 18 48546 1652 42571119
Pneumonia pseudomonal 24.32 13.79 29 48535 4880 42567891
Nephrolithiasis 24.31 13.79 6 48558 36824 42535947
Oropharyngeal pain 24.31 13.79 9 48555 42501 42530270
Fungal skin infection 24.00 13.79 24 48540 3317 42569454
Gallbladder empyema 23.93 13.79 7 48557 68 42572703
Cerebral ventricle collapse 23.82 13.79 8 48556 126 42572645
Weight increased 23.80 13.79 55 48509 107928 42464843
Antibiotic level below therapeutic 23.65 13.79 7 48557 71 42572700
Primary adrenal insufficiency 23.60 13.79 10 48554 306 42572465
Acute myocardial infarction 23.56 13.79 19 48545 58146 42514625
Memory impairment 23.53 13.79 14 48550 50208 42522563
Geotrichum infection 23.51 13.79 12 48552 565 42572206
Acute lymphocytic leukaemia 23.47 13.79 24 48540 3407 42569364
Wheezing 23.33 13.79 17 48547 54764 42518007
Drug dependence 22.95 13.79 3 48561 29091 42543680
Cytomegalovirus enterocolitis 22.66 13.79 16 48548 1367 42571404
Haematochezia 22.55 13.79 20 48544 58416 42514355
Inhibitory drug interaction 22.51 13.79 18 48546 1856 42570915
Splenic candidiasis 22.44 13.79 7 48557 86 42572685
Transaminases increased 22.12 13.79 85 48479 32800 42539971
Cytomegalovirus infection reactivation 22.07 13.79 43 48521 11135 42561636
Cystitis viral 21.83 13.79 15 48549 1227 42571544
Citrobacter infection 21.74 13.79 12 48552 663 42572108
Urinary bladder rupture 21.67 13.79 7 48557 97 42572674
Infection in an immunocompromised host 21.55 13.79 14 48550 1043 42571728
Pneumonia cytomegaloviral 21.48 13.79 25 48539 4101 42568670
Thrombosis 21.38 13.79 28 48536 68483 42504288
Hepatic enzyme increased 21.35 13.79 106 48458 45678 42527093
Renal failure 20.89 13.79 253 48311 143473 42429298
Cardiovascular insufficiency 20.79 13.79 17 48547 1809 42570962
Decreased appetite 20.68 13.79 132 48432 193005 42379766
Sunburn 20.61 13.79 18 48546 2097 42570674
Incorrect dose administered 20.60 13.79 18 48546 52956 42519815
Viral haemorrhagic cystitis 20.57 13.79 17 48547 1837 42570934
Blood cholesterol increased 20.52 13.79 3 48561 26738 42546033
Pallor 20.49 13.79 4 48560 28882 42543889
Abdominal discomfort 20.32 13.79 34 48530 75221 42497550
Granulomatous dermatitis 20.25 13.79 9 48555 310 42572461
Vertigo 20.10 13.79 7 48557 34340 42538431
Urinary tract infection 19.98 13.79 53 48511 99231 42473540
Colitis ulcerative 19.94 13.79 3 48561 26172 42546599
Abdominal pain upper 19.93 13.79 40 48524 82569 42490202
Aspiration bone marrow abnormal 19.88 13.79 7 48557 128 42572643
Coagulopathy 19.86 13.79 63 48501 22099 42550672
Dysbiosis 19.83 13.79 12 48552 789 42571982
Neck pain 19.59 13.79 5 48559 30009 42542762
Transplant rejection 19.58 13.79 46 48518 13542 42559229
Transient ischaemic attack 19.53 13.79 7 48557 33732 42539039
Bacterial sepsis 19.44 13.79 30 48534 6452 42566319
Lentigo 19.38 13.79 12 48552 822 42571949
Hypokalaemia 19.34 13.79 144 48420 71577 42501194
Arthritis 19.33 13.79 12 48552 42053 42530718
Retinal ischaemia 19.24 13.79 10 48554 489 42572282
Migraine 19.16 13.79 3 48561 25411 42547360
Nasal congestion 19.10 13.79 5 48559 29496 42543275
Staphylococcal sepsis 19.09 13.79 41 48523 11373 42561398
Burns first degree 19.08 13.79 4 48560 7 42572764
COVID-19 18.99 13.79 68 48496 115880 42456891
Disease progression 18.80 13.79 248 48316 143408 42429363
Blood beta-D-glucan increased 18.67 13.79 10 48554 520 42572251
Pneumothorax 18.49 13.79 64 48500 23479 42549292
Skin mass 18.40 13.79 25 48539 4791 42567980
Hypersensitivity 18.36 13.79 34 48530 72336 42500435
Dysgeusia 18.30 13.79 8 48556 34181 42538590
Ocular surface squamous neoplasia 18.29 13.79 5 48559 37 42572734
Malabsorption 18.25 13.79 19 48545 2754 42570017
Gastrointestinal fungal infection 18.18 13.79 8 48556 269 42572502
Haemoptysis 18.17 13.79 102 48462 46065 42526706
Osteoarthritis 18.13 13.79 3 48561 24402 42548369
Lactic acidosis 18.06 13.79 15 48549 45246 42527525
Neuroendocrine carcinoma of the skin 17.87 13.79 12 48552 945 42571826
Flushing 17.81 13.79 10 48554 37018 42535753
Escherichia sepsis 17.80 13.79 27 48537 5720 42567051
Pneumocystis jirovecii infection 17.76 13.79 19 48545 2841 42569930
Fungal test positive 17.69 13.79 10 48554 579 42572192
Neuropsychiatric symptoms 17.67 13.79 11 48553 761 42572010
Chills 17.60 13.79 52 48512 94014 42478757
Scintillating scotoma 17.43 13.79 5 48559 45 42572726
Rash 17.41 13.79 217 48347 276737 42296034
Nervous system disorder 17.39 13.79 51 48513 17144 42555627
Arthropathy 17.37 13.79 6 48558 29591 42543180
Bronchial artery embolisation 17.34 13.79 3 48561 0 42572771
Skin infection 17.21 13.79 35 48529 9345 42563426
Feeling hot 17.20 13.79 3 48561 23479 42549292
Acute lymphocytic leukaemia recurrent 16.98 13.79 21 48543 3670 42569101
Pulmonary resection 16.98 13.79 6 48558 111 42572660
Ureaplasma infection 16.97 13.79 10 48554 626 42572145
Chest discomfort 16.94 13.79 29 48535 63587 42509184
Oral papilloma 16.90 13.79 4 48560 15 42572756
Periostosis 16.90 13.79 4 48560 15 42572756
Apraxia 16.87 13.79 14 48550 1521 42571250
Unevaluable event 16.87 13.79 9 48555 34279 42538492
Therapeutic product effect decreased 16.86 13.79 12 48552 39138 42533633
Cerebral artery embolism 16.83 13.79 12 48552 1041 42571730
Urinary retention 16.83 13.79 14 48550 42200 42530571
Colour blindness acquired 16.83 13.79 6 48558 114 42572657
Suicidal ideation 16.83 13.79 18 48546 48143 42524628
Infective aneurysm 16.77 13.79 12 48552 1047 42571724
Blood culture negative 16.70 13.79 5 48559 53 42572718
Gastrointestinal wall thickening 16.62 13.79 15 48549 1824 42570947
Neurological decompensation 16.54 13.79 21 48543 3768 42569003
Diverticulitis 16.48 13.79 3 48561 22770 42550001
Retinal haemorrhage 16.33 13.79 26 48538 5744 42567027
Photoonycholysis 16.32 13.79 4 48560 18 42572753
Mucosal ulceration 16.25 13.79 13 48551 1341 42571430
Sepsis 16.23 13.79 318 48246 199016 42373755
Myocarditis infectious 16.21 13.79 5 48559 59 42572712
Complications of transplant surgery 16.14 13.79 9 48555 507 42572264
Conductive deafness 16.13 13.79 9 48555 508 42572263
Peptic ulcer haemorrhage 16.13 13.79 10 48554 687 42572084
Hyperbilirubinaemia 16.12 13.79 56 48508 20579 42552192
Staphylococcal infection 16.05 13.79 85 48479 37558 42535213
Musculoskeletal pain 16.04 13.79 9 48555 33331 42539440
Acanthamoeba infection 16.03 13.79 9 48555 514 42572257
Injury 16.02 13.79 3 48561 22313 42550458
CARD9 deficiency 15.97 13.79 4 48560 20 42572751
Retinal toxicity 15.97 13.79 9 48555 518 42572253
Therapy interrupted 15.96 13.79 3 48561 22247 42550524
Thoracic haemorrhage 15.94 13.79 7 48557 234 42572537
Enamel anomaly 15.94 13.79 7 48557 234 42572537
Gout 15.94 13.79 6 48558 28049 42544722
Blood glucose increased 15.87 13.79 38 48526 73661 42499110
Atypical mycobacterial pneumonia 15.86 13.79 7 48557 237 42572534
Inflammatory marker increased 15.86 13.79 28 48536 6728 42566043
Hepatitis toxic 15.85 13.79 17 48547 2550 42570221
Ocular toxicity 15.73 13.79 8 48556 374 42572397
Mental disorder due to a general medical condition 15.68 13.79 6 48558 140 42572631
Aspartate aminotransferase 15.64 13.79 6 48558 141 42572630
Palpitations 15.60 13.79 21 48543 50776 42521995
Gastrointestinal mucormycosis 15.55 13.79 8 48556 383 42572388
Graft versus host disease in lung 15.48 13.79 10 48554 738 42572033
Diabetes mellitus 15.45 13.79 28 48536 60059 42512712
General physical health deterioration 15.36 13.79 105 48459 151141 42421630
Cytokine release syndrome 15.35 13.79 95 48469 44432 42528339
Mycobacterium abscessus infection 15.33 13.79 10 48554 750 42572021
Choriomeningitis lymphocytic 15.33 13.79 6 48558 149 42572622
Hepatic infection fungal 15.28 13.79 7 48557 259 42572512
Chronic pulmonary histoplasmosis 15.26 13.79 3 48561 3 42572768
Proteus test positive 15.23 13.79 7 48557 261 42572510
Loss of consciousness 15.23 13.79 54 48510 92300 42480471
Neuroleptic malignant syndrome 15.18 13.79 3 48561 21469 42551302
Overdose 15.15 13.79 65 48499 105199 42467572
Atrial fibrillation 15.14 13.79 95 48469 139498 42433273
Lip ulceration 14.98 13.79 11 48553 999 42571772
Hepatomegaly 14.96 13.79 38 48526 11747 42561024
Death 14.92 13.79 416 48148 470769 42102002
Organ failure 14.78 13.79 16 48548 2424 42570347
Pneumomediastinum 14.77 13.79 18 48546 3098 42569673
Solar dermatitis 14.76 13.79 5 48559 81 42572690
Transverse sinus thrombosis 14.70 13.79 5 48559 82 42572689
Rhinorrhoea 14.70 13.79 9 48555 31785 42540986
Dysphagia 14.49 13.79 39 48525 72680 42500091
Chronic granulomatous disease 14.47 13.79 4 48560 31 42572740
Necrotising ulcerative gingivostomatitis 14.43 13.79 5 48559 87 42572684
Liver function test abnormal 14.40 13.79 74 48490 32317 42540454
Eye abscess 14.37 13.79 6 48558 177 42572594
Clostridium difficile colitis 14.34 13.79 55 48509 21197 42551574
Contusion 14.33 13.79 16 48548 41969 42530802
Drug level abnormal 14.32 13.79 7 48557 300 42572471
Hypotension 14.32 13.79 207 48357 257424 42315347
Head injury 14.29 13.79 3 48561 20579 42552192
Mycoplasma infection 14.28 13.79 9 48555 636 42572135
Ephelides 14.12 13.79 5 48559 93 42572678
Pneumonia aspiration 14.11 13.79 22 48542 50056 42522715
Melaena 14.08 13.79 14 48550 38732 42534039
Eustachian tube disorder 14.05 13.79 3 48561 6 42572765
Chronic kidney disease 14.04 13.79 20 48544 47221 42525550
Aplasia 13.95 13.79 22 48542 4821 42567950
Hypoxia 13.94 13.79 131 48433 69655 42503116
Posterior reversible encephalopathy syndrome 13.91 13.79 39 48525 12782 42559989
Chondritis 13.91 13.79 6 48558 192 42572579
Candida test positive 13.90 13.79 8 48556 479 42572292
Lymphopenia 13.90 13.79 55 48509 21508 42551263

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 1565.31 14.08 1810 73656 498373 110015460
Drug ineffective 1477.89 14.08 3204 72262 1517336 108996497
Bronchopulmonary aspergillosis 1134.81 14.08 504 74962 29359 110484474
Photosensitivity reaction 1073.36 14.08 463 75003 25126 110488707
Aspergillus infection 1066.33 14.08 461 75005 25155 110488678
Mucormycosis 914.92 14.08 324 75142 10304 110503529
Periostitis 888.29 14.08 185 75281 638 110513195
Drug level increased 869.73 14.08 489 74977 47230 110466603
Hallucination, visual 700.42 14.08 398 75068 39207 110474626
Actinic keratosis 685.22 14.08 235 75231 6778 110507055
Multiple organ dysfunction syndrome 681.23 14.08 667 74799 151043 110362790
Drug resistance 587.74 14.08 405 75061 55969 110457864
Squamous cell carcinoma of skin 545.19 14.08 256 75210 16947 110496886
Hallucination 494.81 14.08 467 74999 100965 110412868
Cerebral aspergillosis 454.60 14.08 132 75334 2170 110511663
Respiratory failure 453.23 14.08 642 74824 214690 110299143
Septic shock 433.89 14.08 536 74930 156992 110356841
Pneumonia fungal 402.12 14.08 198 75268 14556 110499277
Pathogen resistance 379.62 14.08 202 75264 17470 110496363
Hepatotoxicity 372.14 14.08 324 75142 63076 110450757
Fungal infection 371.75 14.08 295 75171 50511 110463322
Drug level below therapeutic 370.75 14.08 174 75292 11499 110502334
Systemic mycosis 319.13 14.08 114 75352 3715 110510118
Photodermatosis 318.50 14.08 85 75381 1006 110512827
Fatigue 317.54 14.08 222 75244 1215736 109298097
Drug level decreased 302.75 14.08 177 75289 18371 110495462
Pain 296.56 14.08 141 75325 954814 109559019
Febrile neutropenia 288.58 14.08 655 74811 316112 110197721
Scedosporium infection 286.19 14.08 94 75372 2364 110511469
Cholestasis 286.11 14.08 282 75184 64236 110449597
Squamous cell carcinoma 272.19 14.08 165 75301 18298 110495535
Graft versus host disease 269.38 14.08 165 75301 18641 110495192
Acute myeloid leukaemia 234.20 14.08 200 75266 37910 110475923
Hepatic function abnormal 233.15 14.08 296 75170 88999 110424834
Fusarium infection 225.28 14.08 81 75385 2690 110511143
Disorganised speech 222.22 14.08 84 75382 3219 110510614
Drug ineffective for unapproved indication 218.11 14.08 308 75158 102530 110411303
Neurotoxicity 216.57 14.08 200 75266 42007 110471826
Joint swelling 212.93 14.08 26 75440 442819 110071014
Pulmonary mucormycosis 206.16 14.08 71 75395 2072 110511761
Brain abscess 190.83 14.08 93 75373 6681 110507152
Toxic optic neuropathy 188.31 14.08 59 75407 1269 110512564
Solar lentigo 184.37 14.08 60 75406 1464 110512369
Fluoride increased 179.72 14.08 34 75432 59 110513774
Pruritus 172.46 14.08 91 75375 581469 109932364
Fluorosis 171.60 14.08 38 75428 187 110513646
Nasopharyngitis 171.49 14.08 31 75435 394330 110119503
Arthralgia 171.25 14.08 168 75298 779464 109734369
Pancytopenia 166.32 14.08 411 75055 209202 110304631
Arthropathy 166.11 14.08 7 75459 287515 110226318
Candida infection 164.72 14.08 183 75283 47826 110466007
Pseudomonas infection 164.69 14.08 143 75323 27710 110486123
Rheumatoid arthritis 161.56 14.08 11 75455 299602 110214231
Choroiditis 161.18 14.08 55 75411 1560 110512273
Drug level above therapeutic 159.16 14.08 99 75367 11489 110502344
Fungaemia 157.89 14.08 79 75387 6007 110507826
Visual impairment 157.10 14.08 308 75158 134120 110379713
Swelling 156.12 14.08 26 75440 351015 110162818
Immunosuppressant drug level increased 155.59 14.08 98 75368 11626 110502207
Synovitis 154.04 14.08 8 75458 274084 110239749
Peripheral swelling 151.32 14.08 44 75422 403990 110109843
Off label use 147.80 14.08 1616 73850 1498569 109015264
Musculoskeletal stiffness 145.96 14.08 12 75454 279810 110234023
Drug hypersensitivity 143.75 14.08 65 75401 454025 110059808
Fall 143.18 14.08 121 75345 603361 109910472
Nephropathy toxic 140.55 14.08 130 75336 27348 110486485
Enterococcal infection 139.87 14.08 114 75352 20252 110493581
Disseminated mucormycosis 139.76 14.08 53 75413 2049 110511784
Headache 136.77 14.08 246 75220 882131 109631702
Product dose omission issue 132.12 14.08 29 75437 321753 110192080
Pain in extremity 131.90 14.08 85 75381 487033 110026800
Hepatic cytolysis 130.42 14.08 174 75292 54879 110458954
Infusion related reaction 129.61 14.08 49 75417 381113 110132720
Abdominal discomfort 128.41 14.08 54 75412 393804 110120029
Cytomegalovirus infection 125.80 14.08 170 75296 54274 110459559
Wound 125.23 14.08 9 75457 234428 110279405
Malaise 123.37 14.08 167 75299 671652 109842181
Hypersensitivity 122.98 14.08 61 75405 403937 110109896
Graft versus host disease in gastrointestinal tract 121.61 14.08 76 75390 8892 110504941
Urticaria 120.70 14.08 34 75432 318823 110195010
Xanthopsia 117.97 14.08 31 75435 344 110513489
Fungal endocarditis 117.95 14.08 37 75429 799 110513034
Disseminated aspergillosis 117.63 14.08 49 75417 2431 110511402
Dysplastic naevus 117.43 14.08 37 75429 811 110513022
Therapeutic product effect decreased 115.75 14.08 15 75451 244301 110269532
Aspergilloma 115.40 14.08 36 75430 763 110513070
Dizziness 113.25 14.08 189 75277 698004 109815829
Anxiety 112.98 14.08 47 75419 345031 110168802
Neutropenia 111.84 14.08 529 74937 374091 110139742
Renal impairment 110.81 14.08 331 75135 188114 110325719
Acute respiratory distress syndrome 110.77 14.08 158 75308 53040 110460793
Osteoarthritis 110.54 14.08 3 75463 182620 110331213
Impaired healing 109.70 14.08 6 75460 196711 110317122
Aspergillus test positive 109.66 14.08 37 75429 1013 110512820
Systemic lupus erythematosus 108.36 14.08 21 75445 254317 110259516
Discomfort 107.16 14.08 11 75455 214696 110299137
Injury 106.97 14.08 3 75463 177262 110336571
Nausea 104.84 14.08 461 75005 1235229 109278604
Dyschromatopsia 102.10 14.08 37 75429 1257 110512576
Venoocclusive liver disease 102.07 14.08 84 75382 15123 110498710
Contraindicated product administered 100.63 14.08 23 75443 248244 110265589
Hepatocellular injury 100.47 14.08 147 75319 50495 110463338
Endophthalmitis 100.12 14.08 65 75401 8122 110505711
Pyrexia 99.00 14.08 991 74475 897274 109616559
Blood cholesterol increased 98.95 14.08 7 75459 184778 110329055
Mobility decreased 98.24 14.08 21 75445 237401 110276432
Injection site pain 97.46 14.08 6 75460 177916 110335917
Cytomegalovirus viraemia 96.63 14.08 87 75379 17677 110496156
Chloropsia 95.98 14.08 18 75448 29 110513804
Blood alkaline phosphatase increased 95.85 14.08 173 75293 70762 110443071
Alopecia 95.52 14.08 66 75400 364687 110149146
Drug abuse 94.20 14.08 7 75459 177404 110336429
Cheilitis 94.10 14.08 57 75409 6308 110507525
Type 2 diabetes mellitus 94.08 14.08 7 75459 177225 110336608
Weight increased 93.62 14.08 89 75377 419555 110094278
Pericarditis 93.53 14.08 18 75448 219096 110294737
Blood bilirubin increased 93.52 14.08 178 75288 75794 110438039
Dry mouth 92.98 14.08 13 75453 199935 110313898
Sepsis 92.43 14.08 455 75011 326891 110186942
Wheezing 91.54 14.08 30 75436 255200 110258633
Migraine 90.49 14.08 7 75459 171645 110342188
Gamma-glutamyltransferase increased 89.92 14.08 155 75311 61154 110452679
Visual acuity reduced 89.27 14.08 110 75356 32063 110481770
Delirium 87.87 14.08 246 75220 134779 110379054
Gastrooesophageal reflux disease 87.82 14.08 10 75456 179966 110333867
Hypertrophic osteoarthropathy 87.41 14.08 20 75446 117 110513716
Condition aggravated 87.40 14.08 824 74642 734012 109779821
Fibromyalgia 87.27 14.08 8 75458 170901 110342932
Haemophagocytic lymphohistiocytosis 86.12 14.08 107 75359 31452 110482381
Abdominal pain upper 85.17 14.08 68 75398 349043 110164790
Product use in unapproved indication 83.64 14.08 557 74909 446820 110067013
Disease progression 83.54 14.08 359 75107 243675 110270158
Mental disorder 83.40 14.08 117 75349 38674 110475159
Blood pressure increased 83.25 14.08 36 75430 258337 110255496
Dyspepsia 82.97 14.08 15 75451 190950 110322883
Graft versus host disease in skin 82.90 14.08 58 75408 8196 110505637
Folliculitis 82.60 14.08 9 75457 167644 110346189
Acute graft versus host disease 81.99 14.08 69 75397 12812 110501021
Hypertension 81.78 14.08 139 75327 509945 110003888
Phaeohyphomycosis 81.75 14.08 34 75432 1680 110512153
Dilatation intrahepatic duct acquired 81.36 14.08 28 75438 815 110513018
Asthma 80.44 14.08 35 75431 250256 110263577
Acute graft versus host disease in skin 79.88 14.08 63 75403 10677 110503156
Maternal exposure during pregnancy 79.79 14.08 37 75429 254846 110258987
Contusion 79.28 14.08 30 75436 233331 110280502
Staphylococcal infection 77.75 14.08 157 75309 69787 110444046
Exposure during pregnancy 77.58 14.08 11 75455 167413 110346420
Pneumonia 77.06 14.08 925 74541 875789 109638044
Muscle injury 76.36 14.08 5 75461 140802 110373031
Diarrhoea 76.25 14.08 461 75005 1139044 109374789
Asthenia 76.10 14.08 230 75236 688769 109825064
Torsade de pointes 75.54 14.08 85 75381 22515 110491318
Dyspnoea 75.53 14.08 445 75021 1106427 109407406
C-reactive protein abnormal 75.40 14.08 3 75463 129692 110384141
Geotrichum infection 74.99 14.08 29 75437 1183 110512650
Hepatitis cholestatic 74.54 14.08 75 75391 17491 110496342
Leukaemia recurrent 73.52 14.08 38 75428 3093 110510740
Acute myeloid leukaemia recurrent 73.36 14.08 45 75421 5094 110508739
Muscle spasms 73.24 14.08 50 75416 278107 110235726
Pneumonia bacterial 73.20 14.08 90 75376 26171 110487662
Stenotrophomonas infection 72.84 14.08 47 75419 5811 110508022
Lower respiratory tract infection 72.00 14.08 38 75428 243068 110270765
Rash 70.82 14.08 304 75162 820660 109693173
Cerebral fungal infection 69.99 14.08 24 75442 691 110513142
Klebsiella infection 69.87 14.08 77 75389 19932 110493901
Fungal test positive 69.85 14.08 27 75439 1100 110512733
Drug-induced liver injury 69.69 14.08 210 75256 119857 110393976
Chest pain 69.54 14.08 93 75373 376282 110137551
Acute graft versus host disease in intestine 69.52 14.08 45 75421 5594 110508239
Bursitis 69.33 14.08 5 75461 129913 110383920
Back pain 69.23 14.08 91 75375 370905 110142928
Renal failure 68.29 14.08 321 75145 226253 110287580
Disseminated intravascular coagulation 68.05 14.08 110 75356 41176 110472657
Halo vision 67.75 14.08 23 75443 642 110513191
Lentigo 67.70 14.08 24 75442 764 110513069
Electrocardiogram QT prolonged 67.46 14.08 195 75271 108765 110405068
Pneumothorax 66.50 14.08 100 75366 35185 110478648
Altered state of consciousness 66.02 14.08 131 75335 57495 110456338
Nervous system disorder 65.72 14.08 94 75372 31627 110482206
Septic embolus 65.71 14.08 32 75434 2294 110511539
Lip squamous cell carcinoma 65.61 14.08 19 75447 309 110513524
Posterior reversible encephalopathy syndrome 65.30 14.08 97 75369 33764 110480069
Osteomyelitis fungal 64.96 14.08 20 75446 405 110513428
Inappropriate schedule of product administration 64.60 14.08 29 75437 203608 110310225
Encephalopathy 64.27 14.08 159 75307 80896 110432937
Mediastinitis 64.03 14.08 27 75439 1381 110512452
Sleep disorder 63.47 14.08 28 75438 198616 110315217
Psoriasis 63.01 14.08 10 75456 139983 110373850
Sinusitis 62.61 14.08 66 75400 296622 110217211
Intraocular pressure increased 62.60 14.08 55 75411 10821 110503012
Acute graft versus host disease in liver 62.31 14.08 31 75435 2328 110511505
Obesity 61.54 14.08 4 75462 113347 110400486
Platelet count decreased 61.25 14.08 315 75151 230128 110283705
Chronic graft versus host disease 60.89 14.08 51 75415 9406 110504427
Acute kidney injury 60.89 14.08 682 74784 634748 109879085
Ill-defined disorder 60.68 14.08 16 75450 156837 110356996
Loss of personal independence in daily activities 60.57 14.08 14 75452 150006 110363827
Nocardiosis 60.22 14.08 46 75420 7440 110506393
Depression 60.06 14.08 77 75389 317258 110196575
Abscess fungal 59.44 14.08 19 75447 437 110513396
Chromatopsia 59.14 14.08 21 75445 672 110513161
Musculoskeletal pain 58.16 14.08 26 75440 182997 110330836
Central nervous system fungal infection 57.51 14.08 20 75446 601 110513232
Weight decreased 56.98 14.08 149 75317 467908 110045925
Pulmonary haemorrhage 56.90 14.08 63 75403 16393 110497440
Skin candida 56.82 14.08 29 75437 2299 110511534
Hypokalaemia 56.82 14.08 261 75205 182187 110331646
Haemoptysis 56.61 14.08 140 75326 71214 110442619
Photopsia 56.28 14.08 41 75425 6173 110507660
Pulmonary alveolar haemorrhage 56.07 14.08 69 75397 20081 110493752
BK virus infection 55.69 14.08 56 75410 13050 110500783
Vomiting 55.42 14.08 379 75087 910296 109603537
Cystitis haemorrhagic 55.27 14.08 54 75412 12155 110501678
Suicide attempt 55.11 14.08 4 75462 103390 110410443
Neck pain 54.96 14.08 9 75457 123121 110390712
Neutrophil count decreased 54.42 14.08 194 75272 120747 110393086
Myocardial infarction 54.02 14.08 32 75434 192051 110321782
Product compounding quality issue 53.25 14.08 11 75455 36 110513797
Rectal haemorrhage 52.95 14.08 9 75457 119824 110394009
Bone marrow failure 52.94 14.08 120 75346 57728 110456105
Infective aneurysm 52.86 14.08 24 75442 1468 110512365
Photophobia 52.84 14.08 76 75390 25695 110488138
Central nervous system lesion 52.84 14.08 59 75407 15494 110498339
Fungal skin infection 52.79 14.08 42 75424 7207 110506626
Post transplant lymphoproliferative disorder 52.65 14.08 59 75407 15554 110498279
Gait inability 52.59 14.08 14 75452 136362 110377471
Road traffic accident 52.30 14.08 6 75460 107392 110406441
Mycotic endophthalmitis 51.69 14.08 17 75449 429 110513404
Brain oedema 51.45 14.08 83 75383 31015 110482818
Cytomegalovirus infection reactivation 51.37 14.08 63 75403 18270 110495563
Lower respiratory tract infection fungal 51.23 14.08 20 75446 837 110512996
Lung infiltration 51.04 14.08 73 75393 24555 110489278
Sciatica 50.94 14.08 3 75463 92396 110421437
Pleural effusion 50.80 14.08 248 75218 177461 110336372
Necrosis 50.80 14.08 50 75416 11356 110502477
Systemic candida 50.64 14.08 47 75419 9927 110503906
Dysphoria 50.61 14.08 39 75427 6389 110507444
Abdominal pain 50.53 14.08 180 75286 512809 110001024
Toxoplasmosis 50.46 14.08 30 75436 3209 110510624
Intentional overdose 50.34 14.08 14 75452 132487 110381346
Hypercholesterolaemia 49.93 14.08 3 75463 90834 110422999
Acute lymphocytic leukaemia 49.87 14.08 37 75429 5728 110508105
Sinusitis fungal 49.85 14.08 28 75438 2692 110511141
Enterococcal sepsis 49.84 14.08 30 75436 3282 110510551
Trichosporon infection 49.53 14.08 22 75444 1278 110512555
Brain herniation 49.37 14.08 44 75422 8819 110505014
Injection site erythema 49.18 14.08 4 75462 94172 110419661
Pseudoporphyria 48.92 14.08 19 75447 784 110513049
Pneumonia necrotising 48.89 14.08 24 75442 1751 110512082
Memory impairment 48.46 14.08 38 75428 196906 110316927
Infectious pleural effusion 48.26 14.08 34 75432 4857 110508976
Lip dry 47.73 14.08 6 75460 100077 110413756
Stomatitis 47.67 14.08 69 75397 270173 110243660
Lung abscess 47.51 14.08 34 75432 4978 110508855
Alanine aminotransferase increased 47.30 14.08 249 75217 183524 110330309
Infection in an immunocompromised host 47.02 14.08 24 75442 1903 110511930
Treatment failure 46.90 14.08 337 75129 276897 110236936
Transaminases increased 46.76 14.08 121 75345 63269 110450564
Stress 46.35 14.08 8 75458 105340 110408493
Corneal perforation 45.72 14.08 19 75447 937 110512896
Cytokine release syndrome 45.63 14.08 128 75338 70178 110443655
Acute lymphocytic leukaemia recurrent 45.32 14.08 35 75431 5752 110508081
Pneumonia pseudomonal 45.12 14.08 39 75427 7507 110506326
Alternaria infection 44.67 14.08 19 75447 993 110512840
Polyserositis 44.28 14.08 19 75447 1015 110512818
Pulmonary mass 44.18 14.08 86 75380 37215 110476618
Aspartate aminotransferase increased 44.15 14.08 221 75245 159715 110354118
Hypoxia 43.87 14.08 190 75276 129325 110384508
Hepatic failure 43.49 14.08 124 75342 68615 110445218
Injection site reaction 43.31 14.08 5 75461 89065 110424768
Liver function test abnormal 43.25 14.08 124 75342 68826 110445007
Thrombotic microangiopathy 43.13 14.08 74 75392 29075 110484758
Bronchial anastomosis complication 42.99 14.08 11 75455 109 110513724
Renal abscess 42.74 14.08 21 75445 1535 110512298
Eye infection fungal 42.42 14.08 16 75450 609 110513224
Blood beta-D-glucan increased 42.36 14.08 17 75449 766 110513067
Hypoaesthesia 42.18 14.08 95 75371 314128 110199705
Ovarian failure 42.01 14.08 18 75448 958 110512875
Urinary tract infection 41.91 14.08 101 75365 326181 110187652
Tracheobronchitis 41.90 14.08 25 75441 2691 110511142
Cerebral haemorrhage 41.88 14.08 118 75348 64850 110448983
Constipation 41.19 14.08 117 75349 357669 110156164
Night sweats 41.07 14.08 20 75446 133963 110379870
Hallucinations, mixed 40.38 14.08 39 75427 8654 110505179
Ocular surface squamous neoplasia 40.32 14.08 8 75458 20 110513813
Shock 40.26 14.08 103 75363 53485 110460348
Product contamination microbial 40.04 14.08 18 75448 1076 110512757
Neurological decompensation 40.00 14.08 35 75431 6848 110506985
Gliosis 39.97 14.08 16 75450 716 110513117
Feeling hot 39.90 14.08 7 75459 91099 110422734
Transplant rejection 39.86 14.08 65 75401 24502 110489331
Human polyomavirus infection 39.83 14.08 21 75445 1781 110512052
Toxic skin eruption 39.60 14.08 69 75397 27446 110486387
Dehiscence 39.43 14.08 16 75450 742 110513091
Arthritis 39.16 14.08 34 75432 167552 110346281
Drug intolerance 39.11 14.08 144 75322 406368 110107465
Intentional product misuse 39.00 14.08 21 75445 132883 110380950
Immunosuppressant drug level decreased 38.88 14.08 24 75442 2747 110511086
Inappropriate antidiuretic hormone secretion 38.83 14.08 77 75389 33774 110480059
Palpitations 38.81 14.08 31 75435 159181 110354652
Oropharyngeal pain 38.79 14.08 22 75444 135254 110378579
Uveitis 38.75 14.08 60 75406 21650 110492183
Pneumomediastinum 38.44 14.08 30 75436 5006 110508827
Mixed liver injury 37.95 14.08 44 75422 12035 110501798
Bacterial sepsis 37.93 14.08 41 75425 10385 110503448
Insomnia 37.88 14.08 123 75343 360467 110153366
Macular opacity 37.74 14.08 6 75460 0 110513833
Enterococcal bacteraemia 37.18 14.08 28 75438 4433 110509400
Transmission of an infectious agent via product 37.15 14.08 11 75455 194 110513639
Coagulopathy 36.47 14.08 84 75382 40827 110473006
Neurological symptom 36.44 14.08 49 75417 15559 110498274
Mycobacterium avium complex infection 36.41 14.08 31 75435 5846 110507987
Flushing 36.34 14.08 13 75453 104723 110409110
Scintillating scotoma 35.95 14.08 11 75455 218 110513615
Hyperbilirubinaemia 35.46 14.08 70 75396 30601 110483232
Intracranial infection 35.31 14.08 12 75454 336 110513497
Mycobacterium abscessus infection 35.22 14.08 19 75447 1687 110512146
Hypertransaminasaemia 35.13 14.08 61 75405 24194 110489639
Blister 34.54 14.08 64 75402 227312 110286521
Premature menopause 34.53 14.08 16 75450 1026 110512807
Sunburn 34.52 14.08 27 75439 4521 110509312
Eye abscess 34.40 14.08 12 75454 364 110513469
Upper respiratory tract infection 34.03 14.08 24 75442 131304 110382529
Scopulariopsis infection 33.96 14.08 10 75456 173 110513660
Pneumonia cytomegaloviral 33.82 14.08 32 75434 6922 110506911
Product quality issue 33.72 14.08 6 75460 77293 110436540
Adverse event 33.72 14.08 16 75450 108793 110405040
Citrobacter infection 33.34 14.08 17 75449 1345 110512488
Acinetobacter infection 33.32 14.08 24 75442 3549 110510284
Lung transplant rejection 33.02 14.08 19 75447 1912 110511921
Blood pressure systolic increased 32.99 14.08 8 75458 82983 110430850
Fungal sepsis 32.98 14.08 20 75446 2217 110511616
Pouchitis 32.93 14.08 17 75449 1380 110512453
Microangiopathic haemolytic anaemia 32.91 14.08 19 75447 1924 110511909
Cytopenia 32.74 14.08 67 75399 30049 110483784
Cytomegalovirus enterocolitis 32.62 14.08 20 75446 2261 110511572
Arthritis fungal 32.55 14.08 10 75456 201 110513632
Pericarditis fungal 32.54 14.08 11 75455 303 110513530
Rash maculo-papular 32.48 14.08 118 75348 74104 110439729
Mental status changes 32.45 14.08 120 75346 76002 110437831
Red blood cell sedimentation rate increased 32.22 14.08 7 75459 78295 110435538
Anaphylactic reaction 32.19 14.08 19 75447 114281 110399552
Joint stiffness 32.14 14.08 4 75462 67239 110446594
Pseudoaldosteronism 32.13 14.08 11 75455 315 110513518
Cystitis viral 32.08 14.08 17 75449 1456 110512377
Myoclonus 31.93 14.08 70 75396 32928 110480905
Hyperhidrosis 31.88 14.08 49 75417 187249 110326584
Hepatic infection fungal 31.71 14.08 11 75455 328 110513505
Escherichia sepsis 31.57 14.08 37 75429 10235 110503598
Graft versus host disease in lung 31.43 14.08 16 75450 1262 110512571
Skin mass 31.24 14.08 36 75430 9780 110504053
Chest discomfort 31.03 14.08 44 75422 173804 110340029
Pneumocystis jirovecii infection 30.99 14.08 25 75441 4375 110509458
Basal cell carcinoma 30.94 14.08 84 75382 45186 110468647
Respiratory tract infection fungal 30.89 14.08 16 75450 1308 110512525
Hospitalisation 30.83 14.08 31 75435 142462 110371371
Depressed mood 30.63 14.08 3 75463 60806 110453027
Aplasia 30.48 14.08 32 75434 7841 110505992
Pulmonary embolism 30.30 14.08 63 75403 214411 110299422
Hallucination, auditory 30.22 14.08 60 75406 26337 110487496
Pulmonary fibrosis 30.12 14.08 16 75450 102026 110411807
Syncope 29.89 14.08 58 75408 202478 110311355
Gastrointestinal mucormycosis 29.72 14.08 13 75453 728 110513105
Inflammation 29.70 14.08 54 75412 193184 110320649
Nasal congestion 29.62 14.08 15 75451 98267 110415566
Rhinocerebral mucormycosis 28.85 14.08 16 75450 1501 110512332
Conductive deafness 28.84 14.08 10 75456 298 110513535
Retinal haemorrhage 28.83 14.08 34 75432 9467 110504366
Graft versus host disease in liver 28.75 14.08 19 75447 2446 110511387
Eczema 28.68 14.08 7 75459 72286 110441547
Acanthamoeba infection 28.51 14.08 12 75454 611 110513222
Procalcitonin increased 28.47 14.08 23 75443 4033 110509800
Blood creatinine increased 28.45 14.08 218 75248 182671 110331162
Infection reactivation 28.35 14.08 23 75443 4058 110509775
Pulmonary cavitation 28.26 14.08 18 75448 2176 110511657
Feeling abnormal 28.22 14.08 50 75416 180661 110333172
Cardiac failure congestive 28.18 14.08 37 75429 150963 110362870
Leukaemia 28.12 14.08 30 75436 7488 110506345
Potentiating drug interaction 27.87 14.08 37 75429 11606 110502227
Erythropsia 27.48 14.08 7 75459 68 110513765
Dry skin 27.46 14.08 20 75446 107633 110406200
Differentiation syndrome 27.37 14.08 20 75446 3024 110510809
Vision blurred 27.35 14.08 166 75300 128856 110384977
Renal ischaemia 27.32 14.08 18 75448 2305 110511528
Wound infection 27.21 14.08 16 75450 96449 110417384
Bacterial infection 27.15 14.08 81 75385 45955 110467878
Toxic encephalopathy 27.09 14.08 42 75424 15172 110498661
Immune recovery uveitis 26.97 14.08 8 75458 142 110513691
Tonsillitis bacterial 26.97 14.08 9 75457 238 110513595
Colour blindness acquired 26.92 14.08 8 75458 143 110513690
Mucosal inflammation 26.62 14.08 133 75333 96008 110417825
Capillary leak syndrome 26.62 14.08 24 75442 4884 110508949
Dermatitis bullous 26.59 14.08 45 75421 17484 110496349
Hepatosplenomegaly 26.57 14.08 28 75438 6891 110506942
Nail disorder 26.38 14.08 4 75462 57931 110455902
Urinary tract inflammation 26.33 14.08 10 75456 388 110513445
Dysbiosis 26.25 14.08 17 75449 2115 110511718
Cytomegalovirus test positive 26.18 14.08 28 75438 7008 110506825
Lung consolidation 26.17 14.08 34 75432 10442 110503391
Ileus paralytic 26.12 14.08 36 75430 11701 110502132
Gastrointestinal fungal infection 25.93 14.08 12 75454 767 110513066
Splenic candidiasis 25.84 14.08 7 75459 88 110513745
General physical health deterioration 25.78 14.08 177 75289 425118 110088715
Eye pain 25.72 14.08 84 75382 50015 110463818
Dyspnoea exertional 25.69 14.08 20 75446 104040 110409793
Chronic obstructive pulmonary disease 25.68 14.08 22 75444 109136 110404697
Illness 25.59 14.08 12 75454 82159 110431674
Necrotising retinitis 25.43 14.08 15 75451 1581 110512252
Bacteraemia 25.40 14.08 75 75391 42315 110471518
Aspiration bone marrow abnormal 25.36 14.08 8 75458 176 110513657
Cortical visual impairment 25.30 14.08 6 75460 42 110513791
Upper airway necrosis 25.30 14.08 6 75460 42 110513791
Cerebral ventricle collapse 25.23 14.08 8 75458 179 110513654
Primary adrenal insufficiency 25.20 14.08 11 75455 613 110513220
Ocular toxicity 25.13 14.08 14 75452 1324 110512509
Amnesia 25.09 14.08 21 75445 105387 110408446
Coccidioidomycosis 25.08 14.08 15 75451 1622 110512211
Organ failure 25.04 14.08 23 75443 4794 110509039
Clostridium difficile colitis 24.85 14.08 76 75390 43702 110470131
Leukopenia 24.64 14.08 180 75286 148611 110365222
Hyperammonaemia 24.58 14.08 38 75428 13694 110500139
Oliguria 24.56 14.08 45 75421 18612 110495221
Pregnancy 24.50 14.08 3 75463 51064 110462769
Strongyloidiasis 24.36 14.08 23 75443 4963 110508870
Rhabdomyolysis 24.32 14.08 153 75313 120248 110393585
Meningitis fungal 24.18 14.08 9 75457 330 110513503
Hepatic candidiasis 24.16 14.08 7 75459 114 110513719
Paraesthesia 24 14.08 102 75364 276419 110237414
Proctectomy 23.95 14.08 9 75457 339 110513494
Gait disturbance 23.91 14.08 103 75363 278105 110235728
Medication error 23.86 14.08 22 75444 105344 110408489
Infective pulmonary exacerbation of cystic fibrosis 23.85 14.08 39 75427 14732 110499101
Rhinorrhoea 23.77 14.08 21 75445 102645 110411188
Antiphospholipid syndrome 23.65 14.08 17 75449 2506 110511327
Tongue necrosis 23.41 14.08 7 75459 128 110513705
Viral haemorrhagic cystitis 23.28 14.08 19 75447 3380 110510453
Gallbladder empyema 23.25 14.08 7 75459 131 110513702
Ureaplasma infection 23.25 14.08 14 75452 1532 110512301
Chronic graft versus host disease in skin 23.08 14.08 17 75449 2602 110511231
Haematochezia 22.92 14.08 27 75439 115497 110398336
Hemiparesis 22.89 14.08 74 75392 43829 110470004
Haemodynamic instability 22.65 14.08 49 75417 22839 110490994
Osteonecrosis of jaw 22.60 14.08 3 75463 48014 110465819
Colour blindness 22.53 14.08 10 75456 580 110513253
Respiratory distress 22.52 14.08 100 75366 68774 110445059
Agitation 22.43 14.08 143 75323 112908 110400925
Human herpesvirus 6 infection 22.41 14.08 25 75441 6556 110507277
Mucosal ulceration 22.23 14.08 16 75450 2363 110511470
Organising pneumonia 22.19 14.08 37 75429 14206 110499627
Transient ischaemic attack 22.09 14.08 8 75458 63974 110449859
Agranulocytosis 21.98 14.08 92 75374 61668 110452165
Apallic syndrome 21.95 14.08 12 75454 1094 110512739
Splenic infection fungal 21.86 14.08 7 75459 162 110513671
Urinary bladder rupture 21.82 14.08 7 75459 163 110513670
Angioedema 21.80 14.08 21 75445 98479 110415354
Aspergillus test 21.75 14.08 6 75460 81 110513752
Cardiovascular insufficiency 21.73 14.08 18 75448 3270 110510563
Neuroendocrine carcinoma of the skin 21.69 14.08 14 75452 1731 110512102
Adverse drug reaction 21.67 14.08 24 75442 105535 110408298
Staphylococcal bacteraemia 21.65 14.08 40 75426 16648 110497185
Throat irritation 21.61 14.08 5 75461 53547 110460286
Drug dependence 21.56 14.08 4 75462 50016 110463817
Therapy interrupted 21.44 14.08 4 75462 49818 110464015
Onychomadesis 21.14 14.08 3 75463 45660 110468173
Cerebrovascular accident 21.05 14.08 59 75407 181225 110332608
Granuloma 20.96 14.08 29 75437 9461 110504372
Fungal disease carrier 20.93 14.08 9 75457 483 110513350
Tumour lysis syndrome 20.89 14.08 57 75409 30744 110483089
Stem cell transplant 20.83 14.08 20 75446 4407 110509426
Epstein-Barr virus infection 20.74 14.08 42 75424 18696 110495137
Rhodococcus infection 20.69 14.08 9 75457 497 110513336
Functional residual capacity increased 20.64 14.08 6 75460 99 110513734
Gastrointestinal disorder 20.53 14.08 90 75376 241862 110271971
Adenovirus infection 20.49 14.08 31 75435 10963 110502870
Sedation 20.46 14.08 11 75455 69672 110444161
Granulomatous liver disease 20.42 14.08 13 75453 1571 110512262
Granulomatous dermatitis 20.36 14.08 9 75457 517 110513316
Ectropion 20.29 14.08 9 75457 521 110513312
Primary myelofibrosis 20.27 14.08 7 75459 206 110513627
Neuropsychiatric symptoms 20.25 14.08 12 75454 1276 110512557
Retinal ischaemia 20.19 14.08 11 75455 996 110512837
Swollen tongue 20.09 14.08 8 75458 60354 110453479
Wrong technique in product usage process 20.07 14.08 18 75448 87330 110426503
Klebsiella sepsis 19.99 14.08 19 75447 4134 110509699
Immune reconstitution inflammatory syndrome 19.94 14.08 38 75428 16188 110497645
Venoocclusive disease 19.73 14.08 23 75443 6327 110507506
Disease recurrence 19.68 14.08 88 75378 60696 110453137
Suicidal ideation 19.68 14.08 21 75445 93916 110419917
Angina pectoris 19.55 14.08 9 75457 62286 110451547
Escherichia bacteraemia 19.43 14.08 29 75437 10135 110503698
Chronic granulomatous disease 19.41 14.08 5 75461 51 110513782
Influenza like illness 19.39 14.08 19 75447 88393 110425440
Enamel anomaly 19.34 14.08 7 75459 237 110513596
Dry eye 19.22 14.08 7 75459 55786 110458047
Necrotising colitis 19.13 14.08 13 75453 1752 110512081
Hepatomegaly 19.12 14.08 44 75422 21370 110492463
Pseudomonal sepsis 19.02 14.08 27 75439 9019 110504814
Muscular weakness 18.98 14.08 96 75370 248372 110265461
Blastomycosis 18.96 14.08 11 75455 1124 110512709
Periostosis 18.94 14.08 4 75462 15 110513818
Live birth 18.94 14.08 12 75454 69472 110444361
Rhinovirus infection 18.87 14.08 31 75435 11758 110502075
Solar dermatitis 18.85 14.08 7 75459 255 110513578
Immunosuppression 18.71 14.08 39 75427 17720 110496113
Renal disorder 18.63 14.08 75 75391 49404 110464429
Apraxia 18.59 14.08 17 75449 3523 110510310
Septal panniculitis 18.57 14.08 6 75460 143 110513690
Mental disorder due to a general medical condition 18.52 14.08 7 75459 268 110513565
Disseminated cryptococcosis 18.51 14.08 15 75451 2642 110511191
Pain in jaw 18.36 14.08 6 75460 51171 110462662
Deafness bilateral 18.28 14.08 15 75451 2689 110511144
Somatic symptom disorder 18.23 14.08 16 75450 3143 110510690
Drug clearance decreased 18.23 14.08 18 75448 4104 110509729
Visual field defect 18.20 14.08 28 75438 10044 110503789
Dehydration 18.10 14.08 114 75352 279397 110234436
Back injury 18.02 14.08 5 75461 47394 110466439
CARD9 deficiency 18.01 14.08 4 75462 20 110513813
Antithrombin III deficiency 17.97 14.08 6 75460 159 110513674
Dysgeusia 17.85 14.08 13 75453 69972 110443861
Haemothorax 17.85 14.08 23 75443 7008 110506825
Ear pain 17.80 14.08 7 75459 53219 110460614
Burkholderia cepacia complex infection 17.75 14.08 8 75458 481 110513352
Osteoporosis 17.69 14.08 20 75446 87132 110426701
Blast cell count increased 17.61 14.08 12 75454 1625 110512208
Pseudallescheria infection 17.40 14.08 4 75462 24 110513809
Endocarditis 17.28 14.08 32 75434 13339 110500494
Gastric perforation 17.26 14.08 19 75447 4910 110508923
Choriomeningitis lymphocytic 17.26 14.08 6 75460 180 110513653
Atypical mycobacterial pneumonia 17.24 14.08 7 75459 325 110513508
Imprisonment 17.21 14.08 9 75457 750 110513083
Candida test positive 17.16 14.08 11 75455 1344 110512489
Intentional product use issue 17.16 14.08 99 75367 247807 110266026
Cardiac tamponade 17.12 14.08 29 75437 11278 110502555
Laryngitis 17.03 14.08 4 75462 42407 110471426
Dysphonia 17.02 14.08 16 75450 75913 110437920
Complications of transplant surgery 16.99 14.08 9 75457 770 110513063
Decreased appetite 16.88 14.08 226 75240 475620 110038213
Pulmonary resection 16.84 14.08 6 75460 194 110513639
Diabetic ketoacidosis 16.82 14.08 4 75462 42054 110471779
Chronic pulmonary histoplasmosis 16.79 14.08 3 75463 3 110513830
Exserohilum infection 16.79 14.08 3 75463 3 110513830
Heart rate decreased 16.79 14.08 19 75447 82737 110431096
Photoonycholysis 16.74 14.08 4 75462 29 110513804
Drug level abnormal 16.62 14.08 8 75458 559 110513274
Acute lymphocytic leukaemia refractory 16.61 14.08 6 75460 202 110513631
Pulmonary nocardiosis 16.56 14.08 14 75452 2615 110511218
Blood lactate dehydrogenase increased 16.53 14.08 67 75399 44267 110469566
Gastrointestinal polyp 16.52 14.08 6 75460 205 110513628
Drug withdrawal syndrome 16.50 14.08 3 75463 38051 110475782
Labelled drug-drug interaction issue 16.47 14.08 17 75449 4084 110509749
Ventricular extrasystoles 16.47 14.08 43 75423 22598 110491235
Ileostomy closure 16.45 14.08 7 75459 366 110513467
Corneal bleeding 16.40 14.08 4 75462 32 110513801
Pseudomembranous colitis 16.37 14.08 21 75445 6370 110507463
Mucosal necrosis 16.36 14.08 6 75460 211 110513622
Pneumocystis jirovecii pneumonia 16.27 14.08 65 75401 42670 110471163
Incorrect route of product administration 16.21 14.08 12 75454 64049 110449784
Exophthalmos 16.19 14.08 13 75453 2260 110511573
Burns first degree 16.18 14.08 4 75462 34 110513799
Liver abscess 16.13 14.08 23 75443 7716 110506117
Fungal abscess central nervous system 16.10 14.08 6 75460 221 110513612
Osteitis deformans 16.10 14.08 6 75460 221 110513612
Lactic acidosis 16.06 14.08 24 75442 92787 110421046
Peptic ulcer haemorrhage 16.05 14.08 10 75456 1163 110512670
Encephalitis 16.04 14.08 38 75428 18801 110495032
Torticollis 16.01 14.08 15 75451 3206 110510627
Tuberculosis gastrointestinal 15.99 14.08 8 75458 608 110513225
Obliterative bronchiolitis 15.99 14.08 16 75450 3707 110510126
Herpes simplex 15.89 14.08 34 75432 15730 110498103
Anal infection 15.84 14.08 6 75460 231 110513602
Engraftment syndrome 15.82 14.08 12 75454 1920 110511913
Prescribed overdose 15.79 14.08 22 75444 87559 110426274
Dermatitis exfoliative 15.74 14.08 28 75438 11319 110502514
Pythium insidiosum infection 15.58 14.08 3 75463 6 110513827
Penicillium infection 15.57 14.08 8 75458 643 110513190
Bronchitis 15.49 14.08 55 75411 156977 110356856
Oxygen saturation decreased 15.48 14.08 55 75411 156927 110356906
Rash pruritic 15.43 14.08 27 75439 98042 110415791
Hepatosplenic candidiasis 15.40 14.08 8 75458 658 110513175
Depressed level of consciousness 15.37 14.08 130 75336 112148 110401685
Keratitis fungal 15.36 14.08 7 75459 432 110513401
Complications of transplanted kidney 15.33 14.08 22 75444 7420 110506413
Respiratory acidosis 15.32 14.08 31 75435 13795 110500038
Skin cancer 15.29 14.08 36 75430 17748 110496085
Bilirubin conjugated increased 15.24 14.08 20 75446 6204 110507629
Bone marrow transplant 15.14 14.08 11 75455 1649 110512184
Respirovirus test positive 15.10 14.08 5 75461 129 110513704
Hepatic enzyme increased 15.08 14.08 143 75323 320749 110193084
Myocarditis infectious 15.06 14.08 5 75461 130 110513703
Disorientation 15.02 14.08 91 75375 70580 110443253
Stupor 14.97 14.08 23 75443 8242 110505591
Diverticulitis 14.92 14.08 9 75457 53513 110460320
Cerebral artery embolism 14.88 14.08 12 75454 2100 110511733
Orthostatic hypotension 14.80 14.08 14 75452 66235 110447598
Enterobacter infection 14.74 14.08 19 75447 5792 110508041
Underdose 14.71 14.08 13 75453 63541 110450292
Pneumonia legionella 14.71 14.08 15 75451 3554 110510279
Hot flush 14.70 14.08 14 75452 66022 110447811
Acinetobacter sepsis 14.68 14.08 5 75461 141 110513692
Necrotising scleritis 14.65 14.08 6 75460 285 110513548
Skin infection 14.62 14.08 41 75425 22468 110491365
Venous thrombosis limb 14.60 14.08 18 75448 5247 110508586
X-ray abnormal 14.53 14.08 4 75462 38113 110475720
Ephelides 14.45 14.08 5 75461 148 110513685
Hypoproteinaemia 14.40 14.08 19 75447 5926 110507907
Acute lung injury 14.38 14.08 14 75452 3137 110510696
Inflammatory marker increased 14.34 14.08 31 75435 14438 110499395
Chorioretinitis 14.34 14.08 10 75456 1405 110512428
COVID-19 14.34 14.08 103 75363 244957 110268876
Blood pressure fluctuation 14.30 14.08 18 75448 74806 110439027
Cataract 14.29 14.08 20 75446 79465 110434368
Traumatic haemothorax 14.29 14.08 8 75458 764 110513069
Limb discomfort 14.29 14.08 5 75461 40849 110472984
Liver disorder 14.17 14.08 154 75312 142089 110371744
Acute myocardial infarction 14.17 14.08 22 75444 83755 110430078
Incorrect dose administered 14.17 14.08 31 75435 103610 110410223
Urinary retention 14.13 14.08 16 75450 69667 110444166
Neuroleptic malignant syndrome 14.10 14.08 3 75463 34056 110479777

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatotoxicity 96.10 82.62 22 94 90 113747

Pharmacologic Action:

SourceCodeDescription
ATC J02AC03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
Triazole and tetrazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50183 P450 inhibitor
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:70868 antileishmanial agent
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006727 Hormone Antagonists
MeSH PA D058888 14-alpha Demethylase Inhibitors
MeSH PA D065088 Steroid Synthesis Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065692 Cytochrome P-450 CYP3A Inhibitors

Related Drugs by ATC class:

J02AC Triazole and tetrazole derivatives 5 drugs
fluconazoleisavuconazoniumitraconazoleoteseconazoleposaconazole

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Invasive pulmonary aspergillosis indication 3214003
Candidiasis of the esophagus indication 20639004 DOID:13146
Fusarium infection indication 64250002
Disseminated candidiasis indication 70572005
Candidemia indication 432261003
Fungal Infection due to Scedosporium Apiospermum indication
Prophylaxis of invasive fungal infections in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients indication
Fungal Infection due to Fusarium Solani indication
Oropharyngeal Candidiasis off-label use
Hypocalcemia contraindication 5291005
Torsades de pointes contraindication 31722008
Hypokalemia contraindication 43339004
Cardiomyopathy contraindication 85898001 DOID:0050700
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Visual impairment contraindication 397540003
Breastfeeding (mother) contraindication 413712001
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.93 acidic
pKa2 2.85 Basic
pKa3 1.42 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 4.85 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 4.82 CHEMBL
Cholesterol 24-hydroxylase Enzyme Ki 7.96 CHEMBL
Cytochrome P450 3A4 Enzyme IC50 4.89 CHEMBL
Lanosterol 14-alpha demethylase Enzyme INHIBITOR MIC 8.73 WOMBAT-PK CHEMBL
Lanosterol 14-alpha demethylase Enzyme MIC 5.84 WOMBAT-PK
14-alpha sterol demethylase Cyp51A Enzyme Kd 5.44 CHEMBL
14-alpha sterol demethylase Enzyme Kd 6.37 CHEMBL
Cytochrome P450 11A1 Enzyme Kd 5.32 CHEMBL
Sterol 14-alpha-demethylase Enzyme Kd 7.25 CHEMBL
14-alpha sterol demethylase Enzyme Kd 7.25 CHEMBL
14-alpha sterol demethylase Enzyme Kd 7.25 CHEMBL

External reference:

IDSource
4021347 VUID
N0000148767 NUI
D00578 KEGG_DRUG
4021347 VANDF
C0393080 UMLSCUI
CHEBI:10023 CHEBI
VOR PDB_CHEM_ID
CHEMBL638 ChEMBL_ID
DB00582 DRUGBANK_ID
D065819 MESH_DESCRIPTOR_UI
71616 PUBCHEM_CID
7269 INN_ID
JFU09I87TR UNII
121243 RXNORM
16711 MMSL
179944 MMSL
43734 MMSL
d04803 MMSL
009650 NDDF
385469007 SNOMEDCT_US
386116008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-3160 POWDER, FOR SUSPENSION 40 mg ORAL NDA 34 sections
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-3170 TABLET, FILM COATED 50 mg ORAL NDA 34 sections
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-3180 TABLET, FILM COATED 200 mg ORAL NDA 34 sections
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-3190 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAVENOUS NDA 34 sections
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-3190 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAVENOUS NDA 34 sections
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-3190 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAVENOUS NDA 34 sections
VFEND HUMAN PRESCRIPTION DRUG LABEL 1 0049-4190 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAVENOUS NDA 33 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0121-1091 INJECTION 10 mg INTRAVENOUS ANDA 30 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0378-1626 TABLET, FILM COATED 50 mg ORAL ANDA 31 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0378-1640 TABLET, FILM COATED 200 mg ORAL ANDA 31 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-3416 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAVENOUS ANDA 30 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5667 TABLET, FILM COATED 50 mg ORAL ANDA 30 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-5668 TABLET, FILM COATED 200 mg ORAL ANDA 30 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6596 TABLET, FILM COATED 50 mg ORAL ANDA 28 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-7024 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
VORICONAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 14335-730 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 31 sections
Voriconazole Human Prescription Drug Label 1 16714-198 TABLET, FILM COATED 50 mg ORAL ANDA 28 sections
Voriconazole Human Prescription Drug Label 1 16714-199 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
Voriconazole Human Prescription Drug Label 1 27241-062 TABLET, FILM COATED 50 mg ORAL ANDA 27 sections
Voriconazole Human Prescription Drug Label 1 27241-063 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 31722-224 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 10 mg INTRAVENOUS ANDA 28 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 31722-266 POWDER, FOR SUSPENSION 40 mg ORAL ANDA 29 sections
VORICONAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 40032-038 SUSPENSION 40 mg ORAL ANDA 29 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 40032-088 TABLET, FILM COATED 50 mg ORAL ANDA 28 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 40032-089 TABLET, FILM COATED 200 mg ORAL ANDA 28 sections
VORICONAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 43386-038 POWDER, FOR SUSPENSION 40 mg ORAL ANDA 29 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 43386-088 TABLET, FILM COATED 50 mg ORAL ANDA 29 sections
voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 43386-089 TABLET, FILM COATED 200 mg ORAL ANDA 29 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 43547-377 TABLET, COATED 50 mg ORAL ANDA 18 sections
Voriconazole HUMAN PRESCRIPTION DRUG LABEL 1 43547-378 TABLET, COATED 200 mg ORAL ANDA 18 sections