Stem definition | Drug id | CAS RN |
---|---|---|
systemic antifungal agents, miconazole derivatives | 2846 | 137234-62-9 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
0.40 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.39 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 34.35 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 96 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.42 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.60 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 24, 2002 | FDA | PF PRISM CV |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug interaction | 417.89 | 15.72 | 477 | 21988 | 199144 | 50383515 |
Bronchopulmonary aspergillosis | 378.07 | 15.72 | 138 | 22327 | 7454 | 50575205 |
Mucormycosis | 370.23 | 15.72 | 104 | 22361 | 2379 | 50580280 |
Periostitis | 333.81 | 15.72 | 64 | 22401 | 225 | 50582434 |
Aspergillus infection | 317.53 | 15.72 | 118 | 22347 | 6703 | 50575956 |
Multiple organ dysfunction syndrome | 292.66 | 15.72 | 214 | 22251 | 50123 | 50532536 |
Drug level increased | 211.08 | 15.72 | 122 | 22343 | 19146 | 50563513 |
Drug resistance | 210.06 | 15.72 | 121 | 22344 | 18868 | 50563791 |
Photosensitivity reaction | 203.38 | 15.72 | 104 | 22361 | 12807 | 50569852 |
Septic shock | 192.65 | 15.72 | 177 | 22288 | 56998 | 50525661 |
Febrile neutropenia | 181.37 | 15.72 | 220 | 22245 | 97447 | 50485212 |
Drug level below therapeutic | 160.58 | 15.72 | 61 | 22404 | 3679 | 50578980 |
Pneumonia fungal | 155.51 | 15.72 | 62 | 22403 | 4258 | 50578401 |
Respiratory failure | 151.02 | 15.72 | 194 | 22271 | 90987 | 50491672 |
Drug level decreased | 143.23 | 15.72 | 66 | 22399 | 6467 | 50576192 |
Cholestasis | 138.52 | 15.72 | 104 | 22361 | 25297 | 50557362 |
Fatigue | 132.99 | 15.72 | 75 | 22390 | 707526 | 49875133 |
Acute myeloid leukaemia | 132.81 | 15.72 | 83 | 22382 | 14991 | 50567668 |
Graft versus host disease | 124.97 | 15.72 | 59 | 22406 | 6107 | 50576552 |
Actinic keratosis | 124.04 | 15.72 | 44 | 22421 | 2183 | 50580476 |
Systemic mycosis | 123.74 | 15.72 | 37 | 22428 | 1060 | 50581599 |
Pain | 113.54 | 15.72 | 58 | 22407 | 578845 | 50003814 |
Dilatation intrahepatic duct acquired | 109.86 | 15.72 | 30 | 22435 | 615 | 50582044 |
Pathogen resistance | 107.87 | 15.72 | 52 | 22413 | 5637 | 50577022 |
Hallucination, visual | 106.56 | 15.72 | 75 | 22390 | 16507 | 50566152 |
Cerebral aspergillosis | 106.07 | 15.72 | 26 | 22439 | 341 | 50582318 |
Fungal infection | 103.25 | 15.72 | 94 | 22371 | 29871 | 50552788 |
Squamous cell carcinoma of skin | 100.21 | 15.72 | 48 | 22417 | 5130 | 50577529 |
Hallucination | 96.24 | 15.72 | 111 | 22354 | 46546 | 50536113 |
Fluoride increased | 93.76 | 15.72 | 15 | 22450 | 9 | 50582650 |
Venoocclusive liver disease | 87.05 | 15.72 | 41 | 22424 | 4220 | 50578439 |
Drug ineffective | 86.53 | 15.72 | 639 | 21826 | 818694 | 49763965 |
Visual impairment | 84.04 | 15.72 | 126 | 22339 | 68149 | 50514510 |
Pancytopenia | 84.03 | 15.72 | 141 | 22324 | 83889 | 50498770 |
Hepatotoxicity | 81.50 | 15.72 | 79 | 22386 | 27147 | 50555512 |
Photodermatosis | 79.52 | 15.72 | 21 | 22444 | 377 | 50582282 |
Sepsis | 78.97 | 15.72 | 179 | 22286 | 132746 | 50449913 |
Rheumatoid arthritis | 76.89 | 15.72 | 3 | 22462 | 202547 | 50380112 |
Blood bilirubin increased | 70.77 | 15.72 | 79 | 22386 | 31959 | 50550700 |
Joint swelling | 70.63 | 15.72 | 12 | 22453 | 245274 | 50337385 |
Skin candida | 65.59 | 15.72 | 24 | 22441 | 1302 | 50581357 |
Pulmonary mucormycosis | 65.26 | 15.72 | 16 | 22449 | 210 | 50582449 |
Acute graft versus host disease | 62.64 | 15.72 | 32 | 22433 | 3926 | 50578733 |
Fungaemia | 62.56 | 15.72 | 26 | 22439 | 1986 | 50580673 |
Torsade de pointes | 61.28 | 15.72 | 47 | 22418 | 11788 | 50570871 |
Acute graft versus host disease in intestine | 60.65 | 15.72 | 24 | 22441 | 1615 | 50581044 |
Product use in unapproved indication | 60.10 | 15.72 | 148 | 22317 | 115671 | 50466988 |
Hypertrophic osteoarthropathy | 59.74 | 15.72 | 11 | 22454 | 29 | 50582630 |
Pyrexia | 58.61 | 15.72 | 327 | 22138 | 379876 | 50202783 |
Fall | 57.76 | 15.72 | 39 | 22426 | 334893 | 50247766 |
Arthropathy | 57.75 | 15.72 | 3 | 22462 | 157903 | 50424756 |
Blood alkaline phosphatase increased | 57.62 | 15.72 | 77 | 22388 | 37449 | 50545210 |
Graft versus host disease in gastrointestinal tract | 57.55 | 15.72 | 27 | 22438 | 2754 | 50579905 |
Hepatic function abnormal | 56.33 | 15.72 | 71 | 22394 | 32610 | 50550049 |
Arthralgia | 55.56 | 15.72 | 68 | 22397 | 438634 | 50144025 |
Pneumonia | 55.38 | 15.72 | 321 | 22144 | 378080 | 50204579 |
Gamma-glutamyltransferase increased | 53.68 | 15.72 | 66 | 22399 | 29557 | 50553102 |
Neurotoxicity | 52.25 | 15.72 | 47 | 22418 | 14693 | 50567966 |
Immunosuppressant drug level increased | 51.94 | 15.72 | 26 | 22439 | 3056 | 50579603 |
Acute respiratory distress syndrome | 51.77 | 15.72 | 55 | 22410 | 21044 | 50561615 |
Swelling | 51.27 | 15.72 | 13 | 22452 | 200859 | 50381800 |
Scedosporium infection | 50.59 | 15.72 | 15 | 22450 | 417 | 50582242 |
Abdominal discomfort | 50.24 | 15.72 | 20 | 22445 | 231621 | 50351038 |
Thrombotic microangiopathy | 50.15 | 15.72 | 37 | 22428 | 8754 | 50573905 |
Cytomegalovirus infection | 49.81 | 15.72 | 50 | 22415 | 17912 | 50564747 |
Acute graft versus host disease in liver | 49.54 | 15.72 | 16 | 22449 | 594 | 50582065 |
Acute graft versus host disease in skin | 49.51 | 15.72 | 25 | 22440 | 2993 | 50579666 |
Encephalopathy | 48.46 | 15.72 | 67 | 22398 | 33644 | 50549015 |
Fungal test positive | 48.25 | 15.72 | 15 | 22450 | 491 | 50582168 |
Squamous cell carcinoma | 47.39 | 15.72 | 34 | 22431 | 7705 | 50574954 |
Cytomegalovirus viraemia | 46.76 | 15.72 | 28 | 22437 | 4681 | 50577978 |
Acute myeloid leukaemia recurrent | 46.74 | 15.72 | 19 | 22446 | 1371 | 50581288 |
Electrocardiogram QT prolonged | 46.51 | 15.72 | 83 | 22382 | 51803 | 50530856 |
Toxoplasmosis | 46.39 | 15.72 | 19 | 22446 | 1398 | 50581261 |
Therapeutic product effect decreased | 45.61 | 15.72 | 4 | 22461 | 136046 | 50446613 |
Musculoskeletal stiffness | 45.27 | 15.72 | 3 | 22462 | 128478 | 50454181 |
Geotrichum infection | 45.10 | 15.72 | 14 | 22451 | 456 | 50582203 |
Pruritus | 45.00 | 15.72 | 36 | 22429 | 283532 | 50299127 |
Fluorosis | 44.98 | 15.72 | 8 | 22457 | 16 | 50582643 |
Drug hypersensitivity | 43.55 | 15.72 | 29 | 22436 | 250981 | 50331678 |
Maternal exposure during pregnancy | 43.44 | 15.72 | 9 | 22456 | 159769 | 50422890 |
Nasopharyngitis | 42.91 | 15.72 | 16 | 22449 | 192911 | 50389748 |
Renal impairment | 42.79 | 15.72 | 100 | 22365 | 75561 | 50507098 |
Peripheral swelling | 42.69 | 15.72 | 19 | 22446 | 205917 | 50376742 |
Neutropenia | 42.23 | 15.72 | 153 | 22312 | 147812 | 50434847 |
Candida infection | 41.96 | 15.72 | 52 | 22413 | 23471 | 50559188 |
Graft versus host disease in skin | 41.43 | 15.72 | 21 | 22444 | 2535 | 50580124 |
Pseudomonas infection | 41.42 | 15.72 | 34 | 22431 | 9396 | 50573263 |
Product dose omission issue | 41.30 | 15.72 | 15 | 22450 | 183823 | 50398836 |
Hepatocellular injury | 40.99 | 15.72 | 54 | 22411 | 25893 | 50556766 |
Mixed liver injury | 40.85 | 15.72 | 23 | 22442 | 3428 | 50579231 |
Strongyloidiasis | 40.47 | 15.72 | 15 | 22450 | 844 | 50581815 |
Lentigo | 39.29 | 15.72 | 11 | 22454 | 248 | 50582411 |
Enterococcal infection | 39.27 | 15.72 | 29 | 22436 | 6869 | 50575790 |
Neutrophil count decreased | 39.18 | 15.72 | 72 | 22393 | 45954 | 50536705 |
Chronic graft versus host disease | 39.15 | 15.72 | 21 | 22444 | 2846 | 50579813 |
Alopecia | 39.00 | 15.72 | 31 | 22434 | 245016 | 50337643 |
Fusarium infection | 38.92 | 15.72 | 13 | 22452 | 537 | 50582122 |
Rash | 38.42 | 15.72 | 86 | 22379 | 437385 | 50145274 |
Nervous system disorder | 37.54 | 15.72 | 41 | 22424 | 16182 | 50566477 |
Dizziness | 37.50 | 15.72 | 60 | 22405 | 346309 | 50236350 |
Hepatic cytolysis | 37.24 | 15.72 | 30 | 22435 | 8073 | 50574586 |
Pain in extremity | 36.96 | 15.72 | 40 | 22425 | 272825 | 50309834 |
Posterior reversible encephalopathy syndrome | 36.78 | 15.72 | 39 | 22426 | 14889 | 50567770 |
Corneal perforation | 36.54 | 15.72 | 12 | 22453 | 470 | 50582189 |
Hypomagnesaemia | 36.28 | 15.72 | 48 | 22417 | 23108 | 50559551 |
Fungal endocarditis | 36.12 | 15.72 | 10 | 22455 | 216 | 50582443 |
Endophthalmitis | 36.06 | 15.72 | 20 | 22445 | 2896 | 50579763 |
Liver function test abnormal | 36.04 | 15.72 | 68 | 22397 | 44271 | 50538388 |
Synovitis | 35.75 | 15.72 | 6 | 22459 | 123859 | 50458800 |
Pneumonia bacterial | 35.60 | 15.72 | 28 | 22437 | 7281 | 50575378 |
Toxic encephalopathy | 35.55 | 15.72 | 25 | 22440 | 5490 | 50577169 |
Headache | 35.09 | 15.72 | 112 | 22353 | 506423 | 50076236 |
Lung transplant rejection | 34.66 | 15.72 | 13 | 22452 | 756 | 50581903 |
Hypertransaminasaemia | 34.64 | 15.72 | 21 | 22444 | 3590 | 50579069 |
Exposure during pregnancy | 34.62 | 15.72 | 6 | 22459 | 121009 | 50461650 |
Hypersensitivity | 34.51 | 15.72 | 27 | 22438 | 215134 | 50367525 |
Halo vision | 34.46 | 15.72 | 11 | 22454 | 393 | 50582266 |
Mucosal inflammation | 34.42 | 15.72 | 63 | 22402 | 40079 | 50542580 |
Hypokalaemia | 34.10 | 15.72 | 101 | 22364 | 87891 | 50494768 |
Solar lentigo | 34.02 | 15.72 | 12 | 22453 | 585 | 50582074 |
Altered state of consciousness | 33.69 | 15.72 | 45 | 22420 | 21865 | 50560794 |
Acute kidney injury | 33.60 | 15.72 | 194 | 22271 | 227864 | 50354795 |
Death | 33.51 | 15.72 | 253 | 22212 | 325126 | 50257533 |
Wound | 33.15 | 15.72 | 4 | 22461 | 105790 | 50476869 |
Immunosuppressant drug level decreased | 33.03 | 15.72 | 13 | 22452 | 862 | 50581797 |
Brain abscess | 32.83 | 15.72 | 16 | 22449 | 1775 | 50580884 |
Pulmonary alveolar haemorrhage | 32.53 | 15.72 | 21 | 22444 | 4006 | 50578653 |
Aspergillus test positive | 32.35 | 15.72 | 10 | 22455 | 321 | 50582338 |
Platelet count decreased | 32.04 | 15.72 | 108 | 22357 | 100618 | 50482041 |
Adenovirus infection | 31.88 | 15.72 | 19 | 22446 | 3149 | 50579510 |
Leukaemia recurrent | 31.71 | 15.72 | 14 | 22451 | 1240 | 50581419 |
Infusion related reaction | 31.59 | 15.72 | 18 | 22447 | 169539 | 50413120 |
Granulomatous liver disease | 31.46 | 15.72 | 12 | 22453 | 731 | 50581928 |
Myoclonus | 30.78 | 15.72 | 35 | 22430 | 14435 | 50568224 |
Aspergillus test | 30.67 | 15.72 | 5 | 22460 | 4 | 50582655 |
Aspartate aminotransferase increased | 30.66 | 15.72 | 90 | 22375 | 77908 | 50504751 |
Dyschromatopsia | 30.54 | 15.72 | 10 | 22455 | 388 | 50582271 |
Infective aneurysm | 30.51 | 15.72 | 10 | 22455 | 389 | 50582270 |
Delirium | 30.33 | 15.72 | 58 | 22407 | 38134 | 50544525 |
Bone marrow failure | 29.79 | 15.72 | 48 | 22417 | 27576 | 50555083 |
Chromatopsia | 29.67 | 15.72 | 10 | 22455 | 425 | 50582234 |
Staphylococcal infection | 29.41 | 15.72 | 55 | 22410 | 35561 | 50547098 |
Alanine aminotransferase increased | 29.22 | 15.72 | 96 | 22369 | 88263 | 50494396 |
Systemic candida | 28.77 | 15.72 | 17 | 22448 | 2773 | 50579886 |
Acute lymphocytic leukaemia recurrent | 28.48 | 15.72 | 15 | 22450 | 1960 | 50580699 |
Graft versus host disease in liver | 28.42 | 15.72 | 10 | 22455 | 484 | 50582175 |
Haemoptysis | 28.35 | 15.72 | 45 | 22420 | 25528 | 50557131 |
Photophobia | 28.32 | 15.72 | 34 | 22431 | 14853 | 50567806 |
Primary myelofibrosis | 27.99 | 15.72 | 6 | 22459 | 41 | 50582618 |
Sinusitis | 27.85 | 15.72 | 21 | 22444 | 170537 | 50412122 |
Drug-induced liver injury | 27.85 | 15.72 | 47 | 22418 | 28048 | 50554611 |
Dermatitis bullous | 27.67 | 15.72 | 24 | 22441 | 7149 | 50575510 |
Toxic epidermal necrolysis | 27.61 | 15.72 | 40 | 22425 | 20952 | 50561707 |
Disseminated intravascular coagulation | 27.59 | 15.72 | 36 | 22429 | 17099 | 50565560 |
Malaise | 27.00 | 15.72 | 69 | 22396 | 335463 | 50247196 |
Weight increased | 26.87 | 15.72 | 30 | 22435 | 201861 | 50380798 |
Cerebral fungal infection | 26.63 | 15.72 | 6 | 22459 | 53 | 50582606 |
Fungal skin infection | 26.48 | 15.72 | 18 | 22447 | 3741 | 50578918 |
Venoocclusive disease | 26.21 | 15.72 | 14 | 22451 | 1882 | 50580777 |
Thrombocytopenia | 26.03 | 15.72 | 119 | 22346 | 127554 | 50455105 |
Respirovirus test positive | 25.98 | 15.72 | 5 | 22460 | 18 | 50582641 |
Urinary tract infection | 25.95 | 15.72 | 37 | 22428 | 223983 | 50358676 |
Haemophagocytic lymphohistiocytosis | 25.73 | 15.72 | 25 | 22440 | 8608 | 50574051 |
Cytokine release syndrome | 25.72 | 15.72 | 25 | 22440 | 8609 | 50574050 |
Liver disorder | 25.32 | 15.72 | 53 | 22412 | 37169 | 50545490 |
Colour blindness | 25.25 | 15.72 | 8 | 22457 | 279 | 50582380 |
Leukaemia | 25.24 | 15.72 | 17 | 22448 | 3482 | 50579177 |
Lower respiratory tract infection fungal | 25.03 | 15.72 | 8 | 22457 | 287 | 50582372 |
Pneumothorax | 24.99 | 15.72 | 31 | 22434 | 14003 | 50568656 |
Human herpesvirus 6 infection | 24.60 | 15.72 | 15 | 22450 | 2591 | 50580068 |
Renal failure | 24.48 | 15.72 | 103 | 22362 | 106530 | 50476129 |
Tracheobronchitis | 24.30 | 15.72 | 11 | 22454 | 1033 | 50581626 |
Acute lymphocytic leukaemia | 24.02 | 15.72 | 14 | 22451 | 2227 | 50580432 |
Infective pulmonary exacerbation of cystic fibrosis | 23.75 | 15.72 | 23 | 22442 | 7886 | 50574773 |
Obliterative bronchiolitis | 23.71 | 15.72 | 13 | 22452 | 1840 | 50580819 |
Leukoencephalopathy | 23.64 | 15.72 | 17 | 22448 | 3866 | 50578793 |
Drug intolerance | 23.63 | 15.72 | 38 | 22427 | 219066 | 50363593 |
Keratitis fungal | 23.54 | 15.72 | 6 | 22459 | 93 | 50582566 |
Graft versus host disease in lung | 23.51 | 15.72 | 8 | 22457 | 350 | 50582309 |
Off label use | 23.48 | 15.72 | 317 | 22148 | 474109 | 50108550 |
Nephropathy toxic | 23.46 | 15.72 | 23 | 22442 | 8006 | 50574653 |
Arthritis | 23.32 | 15.72 | 5 | 22460 | 86716 | 50495943 |
Coccidioidomycosis | 23.02 | 15.72 | 10 | 22455 | 852 | 50581807 |
Anxiety | 22.97 | 15.72 | 27 | 22438 | 177579 | 50405080 |
Hyperlactacidaemia | 22.95 | 15.72 | 14 | 22451 | 2419 | 50580240 |
Bacteraemia | 22.73 | 15.72 | 30 | 22435 | 14403 | 50568256 |
Palpitations | 22.45 | 15.72 | 7 | 22458 | 94499 | 50488160 |
Bacterial sepsis | 22.42 | 15.72 | 16 | 22449 | 3596 | 50579063 |
Blood pressure increased | 22.24 | 15.72 | 16 | 22449 | 133116 | 50449543 |
Myocardial infarction | 22.24 | 15.72 | 6 | 22459 | 89021 | 50493638 |
Stenotrophomonas infection | 22.16 | 15.72 | 12 | 22453 | 1657 | 50581002 |
Tonsillitis bacterial | 22.16 | 15.72 | 6 | 22459 | 119 | 50582540 |
Chronic graft versus host disease in skin | 21.81 | 15.72 | 9 | 22456 | 675 | 50581984 |
Infection reactivation | 21.72 | 15.72 | 10 | 22455 | 977 | 50581682 |
Pulmonary haemorrhage | 21.63 | 15.72 | 20 | 22445 | 6472 | 50576187 |
Chronic papillomatous dermatitis | 21.37 | 15.72 | 5 | 22460 | 53 | 50582606 |
Pleural effusion | 21.35 | 15.72 | 82 | 22383 | 81372 | 50501287 |
Pseudoaldosteronism | 21.29 | 15.72 | 5 | 22460 | 54 | 50582605 |
Back pain | 21.16 | 15.72 | 41 | 22424 | 219989 | 50362670 |
Feeling abnormal | 21.07 | 15.72 | 15 | 22450 | 125477 | 50457182 |
Scintillating scotoma | 21.03 | 15.72 | 6 | 22459 | 145 | 50582514 |
Impaired healing | 20.99 | 15.72 | 3 | 22462 | 69783 | 50512876 |
Abdominal pain upper | 20.83 | 15.72 | 24 | 22441 | 159285 | 50423374 |
Procalcitonin increased | 20.78 | 15.72 | 9 | 22456 | 761 | 50581898 |
Disease progression | 20.77 | 15.72 | 91 | 22374 | 95775 | 50486884 |
Septal panniculitis | 20.73 | 15.72 | 5 | 22460 | 61 | 50582598 |
Necrosis | 20.64 | 15.72 | 17 | 22448 | 4719 | 50577940 |
Aplastic anaemia | 20.54 | 15.72 | 21 | 22444 | 7682 | 50574977 |
Osteoarthritis | 20.52 | 15.72 | 3 | 22462 | 68603 | 50514056 |
Hepatic candidiasis | 20.45 | 15.72 | 4 | 22461 | 16 | 50582643 |
Cross sensitivity reaction | 20.31 | 15.72 | 12 | 22453 | 1957 | 50580702 |
Post transplant lymphoproliferative disorder | 20.25 | 15.72 | 16 | 22449 | 4188 | 50578471 |
Tuberculosis gastrointestinal | 19.93 | 15.72 | 7 | 22458 | 337 | 50582322 |
Cytomegalovirus enterocolitis | 19.90 | 15.72 | 8 | 22457 | 561 | 50582098 |
Diarrhoea | 19.72 | 15.72 | 167 | 22298 | 588309 | 49994350 |
Skin exfoliation | 19.62 | 15.72 | 45 | 22420 | 33567 | 50549092 |
Dermatitis exfoliative | 19.42 | 15.72 | 17 | 22448 | 5125 | 50577534 |
Disseminated cryptococcosis | 19.07 | 15.72 | 7 | 22458 | 383 | 50582276 |
Drug ineffective for unapproved indication | 19.00 | 15.72 | 34 | 22431 | 21247 | 50561412 |
Migraine | 18.94 | 15.72 | 5 | 22460 | 75275 | 50507384 |
Agranulocytosis | 18.84 | 15.72 | 34 | 22431 | 21387 | 50561272 |
Central nervous system fungal infection | 18.77 | 15.72 | 5 | 22460 | 93 | 50582566 |
Chest pain | 18.76 | 15.72 | 31 | 22434 | 176851 | 50405808 |
Urticaria | 18.64 | 15.72 | 18 | 22447 | 129543 | 50453116 |
Babesiosis | 18.57 | 15.72 | 6 | 22459 | 223 | 50582436 |
Dyspepsia | 18.49 | 15.72 | 5 | 22460 | 74092 | 50508567 |
Shock | 18.45 | 15.72 | 33 | 22432 | 20617 | 50562042 |
Blood lactate dehydrogenase increased | 18.43 | 15.72 | 32 | 22433 | 19530 | 50563129 |
Cholecystitis acute | 18.28 | 15.72 | 19 | 22446 | 7087 | 50575572 |
Rash maculo-papular | 18.20 | 15.72 | 38 | 22427 | 26603 | 50556056 |
Contusion | 18.06 | 15.72 | 14 | 22451 | 112169 | 50470490 |
Trichosporon infection | 18.05 | 15.72 | 6 | 22459 | 244 | 50582415 |
Hallucination, auditory | 17.99 | 15.72 | 23 | 22442 | 10705 | 50571954 |
Cerebral haemorrhage | 17.80 | 15.72 | 38 | 22427 | 27014 | 50555645 |
Hepatosplenic candidiasis | 17.78 | 15.72 | 6 | 22459 | 256 | 50582403 |
Flushing | 17.74 | 15.72 | 4 | 22461 | 67011 | 50515648 |
Encephalitis | 17.68 | 15.72 | 19 | 22446 | 7361 | 50575298 |
Cystitis haemorrhagic | 17.64 | 15.72 | 14 | 22451 | 3688 | 50578971 |
Gastrooesophageal reflux disease | 17.55 | 15.72 | 6 | 22459 | 76422 | 50506237 |
Nausea | 17.52 | 15.72 | 215 | 22250 | 705183 | 49877476 |
Muscle spasms | 17.42 | 15.72 | 18 | 22447 | 125535 | 50457124 |
Drug clearance decreased | 17.35 | 15.72 | 9 | 22456 | 1140 | 50581519 |
Cytomegalovirus test positive | 17.29 | 15.72 | 12 | 22453 | 2580 | 50580079 |
Eye abscess | 17.25 | 15.72 | 5 | 22460 | 128 | 50582531 |
Bacterial infection | 17.16 | 15.72 | 28 | 22437 | 16253 | 50566406 |
Laryngeal inflammation | 17.11 | 15.72 | 5 | 22460 | 132 | 50582527 |
Stem cell transplant | 16.77 | 15.72 | 10 | 22455 | 1658 | 50581001 |
Pericarditis | 16.70 | 15.72 | 7 | 22458 | 78682 | 50503977 |
Sphingomonas paucimobilis infection | 16.64 | 15.72 | 4 | 22461 | 48 | 50582611 |
Cytopenia | 16.62 | 15.72 | 20 | 22445 | 8755 | 50573904 |
Xanthopsia | 16.22 | 15.72 | 5 | 22460 | 159 | 50582500 |
Disseminated aspergillosis | 16.21 | 15.72 | 4 | 22461 | 54 | 50582605 |
Melanoderma | 16.13 | 15.72 | 5 | 22460 | 162 | 50582497 |
Anal infection | 16.01 | 15.72 | 4 | 22461 | 57 | 50582602 |
Neck pain | 15.94 | 15.72 | 3 | 22462 | 57064 | 50525595 |
Inappropriate schedule of product administration | 15.88 | 15.72 | 6 | 22459 | 71825 | 50510834 |
Respiratory distress | 15.82 | 15.72 | 39 | 22426 | 30450 | 50552209 |
Apallic syndrome | 15.79 | 15.72 | 7 | 22458 | 626 | 50582033 |
Shock haemorrhagic | 15.77 | 15.72 | 19 | 22446 | 8325 | 50574334 |
Mycobacterial peritonitis | 15.76 | 15.72 | 4 | 22461 | 61 | 50582598 |
Sunburn | 15.74 | 15.72 | 11 | 22454 | 2392 | 50580267 |
Sputum increased | 15.73 | 15.72 | 10 | 22455 | 1857 | 50580802 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Photosensitivity reaction | 659.06 | 13.92 | 286 | 34706 | 8972 | 29530563 |
Drug interaction | 502.94 | 13.92 | 862 | 34130 | 196523 | 29343012 |
Bronchopulmonary aspergillosis | 466.90 | 13.92 | 247 | 34745 | 12097 | 29527438 |
Aspergillus infection | 441.05 | 13.92 | 226 | 34766 | 10355 | 29529180 |
Drug level increased | 432.33 | 13.92 | 272 | 34720 | 18515 | 29521020 |
Periostitis | 349.53 | 13.92 | 77 | 34915 | 180 | 29539355 |
Actinic keratosis | 343.20 | 13.92 | 139 | 34853 | 3647 | 29535888 |
Drug ineffective | 334.45 | 13.92 | 1062 | 33930 | 362108 | 29177427 |
Mucormycosis | 330.28 | 13.92 | 148 | 34844 | 5010 | 29534525 |
Cerebral aspergillosis | 266.12 | 13.92 | 88 | 34904 | 1268 | 29538267 |
Squamous cell carcinoma of skin | 245.21 | 13.92 | 148 | 34844 | 9338 | 29530197 |
Drug resistance | 225.66 | 13.92 | 194 | 34798 | 21346 | 29518189 |
Hallucination, visual | 216.36 | 13.92 | 163 | 34829 | 14852 | 29524683 |
Multiple organ dysfunction syndrome | 206.72 | 13.92 | 310 | 34682 | 62806 | 29476729 |
Hallucination | 176.33 | 13.92 | 240 | 34752 | 44472 | 29495063 |
Fungal infection | 174.10 | 13.92 | 138 | 34854 | 13547 | 29525988 |
Graft versus host disease | 169.42 | 13.92 | 118 | 34874 | 9510 | 29530025 |
Photodermatosis | 163.22 | 13.92 | 47 | 34945 | 412 | 29539123 |
Hepatotoxicity | 151.72 | 13.92 | 143 | 34849 | 17724 | 29521811 |
Fatigue | 146.49 | 13.92 | 98 | 34894 | 316723 | 29222812 |
Squamous cell carcinoma | 142.60 | 13.92 | 109 | 34883 | 10142 | 29529393 |
Choroiditis | 139.00 | 13.92 | 50 | 34942 | 938 | 29538597 |
Septic shock | 138.65 | 13.92 | 258 | 34734 | 62302 | 29477233 |
Scedosporium infection | 138.39 | 13.92 | 47 | 34945 | 738 | 29538797 |
Respiratory failure | 136.88 | 13.92 | 333 | 34659 | 96798 | 29442737 |
Pathogen resistance | 127.86 | 13.92 | 93 | 34899 | 8023 | 29531512 |
Condition aggravated | 127.16 | 13.92 | 421 | 34571 | 145874 | 29393661 |
Systemic mycosis | 121.41 | 13.92 | 49 | 34943 | 1272 | 29538263 |
Pneumonia fungal | 111.56 | 13.92 | 75 | 34917 | 5702 | 29533833 |
Cholestasis | 108.04 | 13.92 | 136 | 34856 | 23326 | 29516209 |
Febrile neutropenia | 104.66 | 13.92 | 331 | 34661 | 111909 | 29427626 |
Visual impairment | 102.99 | 13.92 | 150 | 34842 | 29558 | 29509977 |
Solar lentigo | 97.86 | 13.92 | 31 | 34961 | 386 | 29539149 |
Hepatic function abnormal | 97.23 | 13.92 | 170 | 34822 | 39089 | 29500446 |
Completed suicide | 93.22 | 13.92 | 3 | 34989 | 90243 | 29449292 |
Fluoride increased | 91.61 | 13.92 | 20 | 34972 | 44 | 29539491 |
Cheilitis | 91.26 | 13.92 | 46 | 34946 | 2030 | 29537505 |
Drug level below therapeutic | 91.09 | 13.92 | 59 | 34933 | 4212 | 29535323 |
Disseminated mucormycosis | 90.73 | 13.92 | 28 | 34964 | 318 | 29539217 |
Dysplastic naevus | 84.81 | 13.92 | 28 | 34964 | 401 | 29539134 |
Fall | 78.74 | 13.92 | 57 | 34935 | 177121 | 29362414 |
Drug abuse | 77.98 | 13.92 | 4 | 34988 | 79879 | 29459656 |
Myocardial infarction | 77.02 | 13.92 | 18 | 34974 | 110278 | 29429257 |
Fluorosis | 75.38 | 13.92 | 17 | 34975 | 46 | 29539489 |
Drug level decreased | 75.18 | 13.92 | 61 | 34931 | 6186 | 29533349 |
Product dose omission issue | 72.95 | 13.92 | 13 | 34979 | 96370 | 29443165 |
Immunosuppressant drug level increased | 69.20 | 13.92 | 52 | 34940 | 4713 | 29534822 |
Acute myeloid leukaemia | 67.08 | 13.92 | 90 | 34902 | 16423 | 29523112 |
Fungaemia | 66.80 | 13.92 | 38 | 34954 | 2143 | 29537392 |
Drug level above therapeutic | 66.38 | 13.92 | 44 | 34948 | 3266 | 29536269 |
Fusarium infection | 65.05 | 13.92 | 29 | 34963 | 968 | 29538567 |
Candida infection | 64.96 | 13.92 | 85 | 34907 | 15140 | 29524395 |
Dyschromatopsia | 63.27 | 13.92 | 21 | 34971 | 306 | 29539229 |
Intraocular pressure increased | 62.40 | 13.92 | 49 | 34943 | 4740 | 29534795 |
Treatment failure | 62.21 | 13.92 | 136 | 34856 | 36803 | 29502732 |
Pain | 61.88 | 13.92 | 67 | 34925 | 171365 | 29368170 |
Asthenia | 60.61 | 13.92 | 101 | 34891 | 215149 | 29324386 |
Visual acuity reduced | 60.30 | 13.92 | 81 | 34911 | 14795 | 29524740 |
Dyspnoea | 59.36 | 13.92 | 194 | 34798 | 326538 | 29212997 |
Uveitis | 57.08 | 13.92 | 51 | 34941 | 5896 | 29533639 |
Nephropathy toxic | 53.76 | 13.92 | 65 | 34927 | 10691 | 29528844 |
Graft versus host disease in gastrointestinal tract | 52.83 | 13.92 | 38 | 34954 | 3220 | 29536315 |
Hepatocellular injury | 52.57 | 13.92 | 92 | 34900 | 21151 | 29518384 |
Depression | 51.84 | 13.92 | 18 | 34974 | 85129 | 29454406 |
Acute myeloid leukaemia recurrent | 51.81 | 13.92 | 30 | 34962 | 1750 | 29537785 |
Neurological symptom | 51.67 | 13.92 | 38 | 34954 | 3332 | 29536203 |
Diarrhoea | 51.55 | 13.92 | 211 | 34781 | 332487 | 29207048 |
Inappropriate antidiuretic hormone secretion | 51.31 | 13.92 | 64 | 34928 | 10868 | 29528667 |
Drug ineffective for unapproved indication | 51.03 | 13.92 | 73 | 34919 | 14141 | 29525394 |
Disseminated intravascular coagulation | 50.06 | 13.92 | 87 | 34905 | 19893 | 29519642 |
Nausea | 48.93 | 13.92 | 177 | 34815 | 289078 | 29250457 |
Aspergilloma | 48.86 | 13.92 | 17 | 34975 | 288 | 29539247 |
Liver disorder | 47.67 | 13.92 | 103 | 34889 | 27646 | 29511889 |
Pruritus | 47.55 | 13.92 | 41 | 34951 | 116808 | 29422727 |
Dizziness | 46.30 | 13.92 | 97 | 34895 | 189587 | 29349948 |
Mediastinitis | 46.21 | 13.92 | 20 | 34972 | 621 | 29538914 |
Anxiety | 45.56 | 13.92 | 22 | 34970 | 85343 | 29454192 |
Pseudomonas infection | 45.38 | 13.92 | 60 | 34932 | 10792 | 29528743 |
Constipation | 45.32 | 13.92 | 41 | 34951 | 114119 | 29425416 |
Eye pain | 45.27 | 13.92 | 62 | 34930 | 11533 | 29528002 |
Pain in extremity | 43.43 | 13.92 | 40 | 34952 | 110393 | 29429142 |
Toxic optic neuropathy | 43.43 | 13.92 | 20 | 34972 | 721 | 29538814 |
Leukaemia recurrent | 43.27 | 13.92 | 25 | 34967 | 1452 | 29538083 |
Brain abscess | 43.12 | 13.92 | 31 | 34961 | 2624 | 29536911 |
Aspergillus test positive | 43.01 | 13.92 | 17 | 34975 | 417 | 29539118 |
Renal ischaemia | 42.83 | 13.92 | 18 | 34974 | 519 | 29539016 |
Blood pressure increased | 42.57 | 13.92 | 17 | 34975 | 73786 | 29465749 |
Chest pain | 42.35 | 13.92 | 42 | 34950 | 111931 | 29427604 |
Arthralgia | 41.61 | 13.92 | 63 | 34929 | 139554 | 29399981 |
Product compounding quality issue | 41.16 | 13.92 | 9 | 34983 | 20 | 29539515 |
Neurotoxicity | 41.08 | 13.92 | 67 | 34925 | 14546 | 29524989 |
Acute graft versus host disease in skin | 40.86 | 13.92 | 38 | 34954 | 4626 | 29534909 |
Product use in unapproved indication | 39.46 | 13.92 | 205 | 34787 | 86670 | 29452865 |
Acute graft versus host disease | 39.03 | 13.92 | 41 | 34951 | 5783 | 29533752 |
Cardiac failure congestive | 38.98 | 13.92 | 21 | 34971 | 76560 | 29462975 |
Xanthopsia | 38.59 | 13.92 | 12 | 34980 | 140 | 29539395 |
Photophobia | 38.04 | 13.92 | 41 | 34951 | 5954 | 29533581 |
Dehydration | 37.97 | 13.92 | 48 | 34944 | 114700 | 29424835 |
Acute graft versus host disease in liver | 37.49 | 13.92 | 22 | 34970 | 1316 | 29538219 |
Blood alkaline phosphatase increased | 37.38 | 13.92 | 95 | 34897 | 28311 | 29511224 |
Hepatitis cholestatic | 36.66 | 13.92 | 43 | 34949 | 6850 | 29532685 |
Enterococcal infection | 36.57 | 13.92 | 47 | 34945 | 8221 | 29531314 |
Peripheral swelling | 36.24 | 13.92 | 15 | 34977 | 63724 | 29475811 |
Phaeohyphomycosis | 35.97 | 13.92 | 18 | 34974 | 782 | 29538753 |
Nasopharyngitis | 35.65 | 13.92 | 13 | 34979 | 59652 | 29479883 |
Burns second degree | 35.32 | 13.92 | 14 | 34978 | 346 | 29539189 |
Enterococcal sepsis | 35.14 | 13.92 | 22 | 34970 | 1480 | 29538055 |
Cytomegalovirus viraemia | 34.57 | 13.92 | 40 | 34952 | 6280 | 29533255 |
Weight decreased | 34.46 | 13.92 | 80 | 34912 | 150825 | 29388710 |
Product contamination microbial | 34.28 | 13.92 | 16 | 34976 | 595 | 29538940 |
Septic embolus | 34.07 | 13.92 | 19 | 34973 | 1031 | 29538504 |
Cytokine release syndrome | 34.00 | 13.92 | 58 | 34934 | 13061 | 29526474 |
Back pain | 33.61 | 13.92 | 43 | 34949 | 102241 | 29437294 |
Nocardiosis | 33.37 | 13.92 | 29 | 34963 | 3231 | 29536304 |
Pseudoporphyria | 33.23 | 13.92 | 13 | 34979 | 310 | 29539225 |
Alternaria infection | 33.08 | 13.92 | 13 | 34979 | 314 | 29539221 |
Lip squamous cell carcinoma | 32.90 | 13.92 | 9 | 34983 | 64 | 29539471 |
Acute respiratory distress syndrome | 32.59 | 13.92 | 79 | 34913 | 22856 | 29516679 |
Stenotrophomonas infection | 32.45 | 13.92 | 22 | 34970 | 1695 | 29537840 |
Hyperhidrosis | 32.40 | 13.92 | 18 | 34974 | 64522 | 29475013 |
Drug-induced liver injury | 32.29 | 13.92 | 76 | 34916 | 21579 | 29517956 |
Intentional overdose | 31.88 | 13.92 | 4 | 34988 | 38524 | 29501011 |
Malaise | 31.54 | 13.92 | 91 | 34901 | 159511 | 29380024 |
Fungal endocarditis | 31.04 | 13.92 | 12 | 34980 | 277 | 29539258 |
Graft versus host disease in skin | 30.51 | 13.92 | 28 | 34964 | 3351 | 29536184 |
Venoocclusive liver disease | 30.09 | 13.92 | 39 | 34953 | 6878 | 29532657 |
Transaminases increased | 30.03 | 13.92 | 76 | 34916 | 22586 | 29516949 |
Urinary tract infection | 29.89 | 13.92 | 25 | 34967 | 72329 | 29467206 |
Inappropriate schedule of product administration | 29.58 | 13.92 | 8 | 34984 | 44464 | 29495071 |
Scopulariopsis infection | 29.34 | 13.92 | 9 | 34983 | 100 | 29539435 |
Pyrexia | 29.26 | 13.92 | 490 | 34502 | 287132 | 29252403 |
Pneumonia | 29.21 | 13.92 | 536 | 34456 | 319636 | 29219899 |
Headache | 28.99 | 13.92 | 107 | 34885 | 173900 | 29365635 |
Hypertension | 28.94 | 13.92 | 59 | 34933 | 116555 | 29422980 |
Lower respiratory tract infection fungal | 28.93 | 13.92 | 14 | 34978 | 565 | 29538970 |
Cerebrovascular accident | 28.89 | 13.92 | 29 | 34963 | 76882 | 29462653 |
Cystitis haemorrhagic | 28.79 | 13.92 | 32 | 34960 | 4810 | 29534725 |
Post transplant lymphoproliferative disorder | 28.77 | 13.92 | 34 | 34958 | 5459 | 29534076 |
Macular opacity | 28.70 | 13.92 | 5 | 34987 | 0 | 29539535 |
Off label use | 28.64 | 13.92 | 507 | 34485 | 300293 | 29239242 |
Hepatic failure | 28.42 | 13.92 | 92 | 34900 | 31420 | 29508115 |
Chronic graft versus host disease | 28.14 | 13.92 | 29 | 34963 | 4000 | 29535535 |
Torsade de pointes | 28.11 | 13.92 | 37 | 34955 | 6624 | 29532911 |
Lentigo | 27.83 | 13.92 | 12 | 34980 | 369 | 29539166 |
Injection site pain | 27.76 | 13.92 | 3 | 34989 | 32443 | 29507092 |
Pulmonary cavitation | 27.70 | 13.92 | 15 | 34977 | 768 | 29538767 |
Trichosporon infection | 27.60 | 13.92 | 14 | 34978 | 626 | 29538909 |
Gallbladder oedema | 27.53 | 13.92 | 10 | 34982 | 193 | 29539342 |
Rheumatoid arthritis | 27.44 | 13.92 | 3 | 34989 | 32149 | 29507386 |
Dyspnoea exertional | 27.42 | 13.92 | 5 | 34987 | 36485 | 29503050 |
Vomiting | 27.21 | 13.92 | 144 | 34848 | 212116 | 29327419 |
Neutropenia | 27.05 | 13.92 | 256 | 34736 | 131455 | 29408080 |
Gamma-glutamyltransferase increased | 26.83 | 13.92 | 81 | 34911 | 26656 | 29512879 |
Central nervous system lesion | 26.39 | 13.92 | 33 | 34959 | 5615 | 29533920 |
Eye infection fungal | 26.28 | 13.92 | 11 | 34981 | 314 | 29539221 |
Arthritis fungal | 25.99 | 13.92 | 8 | 34984 | 90 | 29539445 |
Osteomyelitis fungal | 25.86 | 13.92 | 10 | 34982 | 231 | 29539304 |
Central nervous system fungal infection | 25.77 | 13.92 | 11 | 34981 | 330 | 29539205 |
Rectal haemorrhage | 25.39 | 13.92 | 5 | 34987 | 34544 | 29504991 |
Dyspepsia | 25.23 | 13.92 | 3 | 34989 | 30122 | 29509413 |
Halo vision | 25.21 | 13.92 | 9 | 34983 | 165 | 29539370 |
Muscle spasms | 25.07 | 13.92 | 24 | 34968 | 65058 | 29474477 |
Urticaria | 24.99 | 13.92 | 17 | 34975 | 54643 | 29484892 |
Photopsia | 24.97 | 13.92 | 19 | 34973 | 1754 | 29537781 |
Transmission of an infectious agent via product | 24.96 | 13.92 | 9 | 34983 | 170 | 29539365 |
Cytomegalovirus infection | 24.88 | 13.92 | 72 | 34920 | 23143 | 29516392 |
Gallbladder empyema | 24.87 | 13.92 | 7 | 34985 | 56 | 29539479 |
Tongue necrosis | 24.82 | 13.92 | 6 | 34986 | 24 | 29539511 |
Gastrooesophageal reflux disease | 24.35 | 13.92 | 4 | 34988 | 31492 | 29508043 |
Chloropsia | 24.34 | 13.92 | 5 | 34987 | 7 | 29539528 |
Lung infiltration | 24.09 | 13.92 | 47 | 34945 | 11732 | 29527803 |
Chromatopsia | 23.60 | 13.92 | 9 | 34983 | 200 | 29539335 |
Pulmonary mass | 23.35 | 13.92 | 44 | 34948 | 10704 | 29528831 |
Infectious pleural effusion | 23.32 | 13.92 | 19 | 34973 | 1937 | 29537598 |
Pulmonary embolism | 23.29 | 13.92 | 34 | 34958 | 76500 | 29463035 |
Splenic candidiasis | 23.22 | 13.92 | 7 | 34985 | 73 | 29539462 |
Hypertrophic osteoarthropathy | 22.88 | 13.92 | 7 | 34985 | 77 | 29539458 |
Nervous system disorder | 22.86 | 13.92 | 48 | 34944 | 12626 | 29526909 |
Haemophagocytic lymphohistiocytosis | 22.82 | 13.92 | 43 | 34949 | 10461 | 29529074 |
Asthma | 22.68 | 13.92 | 6 | 34986 | 33843 | 29505692 |
Retinal ischaemia | 22.65 | 13.92 | 10 | 34982 | 326 | 29539209 |
Musculoskeletal stiffness | 22.64 | 13.92 | 8 | 34984 | 37450 | 29502085 |
Altered state of consciousness | 22.60 | 13.92 | 63 | 34929 | 19826 | 29519709 |
Pancytopenia | 22.53 | 13.92 | 172 | 34820 | 82996 | 29456539 |
Toxic skin eruption | 22.52 | 13.92 | 41 | 34951 | 9716 | 29529819 |
Urinary bladder rupture | 22.41 | 13.92 | 7 | 34985 | 83 | 29539452 |
Acute graft versus host disease in intestine | 22.31 | 13.92 | 20 | 34972 | 2321 | 29537214 |
Acute lymphocytic leukaemia | 22.21 | 13.92 | 21 | 34971 | 2610 | 29536925 |
Abscess fungal | 22.14 | 13.92 | 8 | 34984 | 152 | 29539383 |
Pulmonary alveolar haemorrhage | 21.78 | 13.92 | 32 | 34960 | 6348 | 29533187 |
Disease recurrence | 21.74 | 13.92 | 54 | 34938 | 15860 | 29523675 |
Pulmonary haemorrhage | 21.45 | 13.92 | 39 | 34953 | 9231 | 29530304 |
Sepsis | 21.22 | 13.92 | 260 | 34732 | 142422 | 29397113 |
Drug hypersensitivity | 21.20 | 13.92 | 30 | 34962 | 68376 | 29471159 |
Aplasia | 21.03 | 13.92 | 25 | 34967 | 4038 | 29535497 |
Acute myocardial infarction | 20.92 | 13.92 | 16 | 34976 | 48422 | 29491113 |
Joint swelling | 20.67 | 13.92 | 17 | 34975 | 49613 | 29489922 |
Angina pectoris | 20.53 | 13.92 | 4 | 34988 | 27846 | 29511689 |
Disseminated aspergillosis | 20.49 | 13.92 | 10 | 34982 | 411 | 29539124 |
Ureaplasma infection | 20.36 | 13.92 | 8 | 34984 | 193 | 29539342 |
Prostate cancer | 20.29 | 13.92 | 3 | 34989 | 25524 | 29514011 |
Gait disturbance | 20.04 | 13.92 | 35 | 34957 | 73314 | 29466221 |
Citrobacter infection | 20.03 | 13.92 | 10 | 34982 | 432 | 29539103 |
Intentional product misuse | 19.95 | 13.92 | 8 | 34984 | 34653 | 29504882 |
Necrotising retinitis | 19.88 | 13.92 | 12 | 34980 | 756 | 29538779 |
Sunburn | 19.87 | 13.92 | 16 | 34976 | 1604 | 29537931 |
Antibiotic level below therapeutic | 19.87 | 13.92 | 6 | 34986 | 63 | 29539472 |
Mycobacterium abscessus infection | 19.78 | 13.92 | 10 | 34982 | 444 | 29539091 |
Hallucinations, mixed | 19.74 | 13.92 | 19 | 34973 | 2414 | 29537121 |
Klebsiella infection | 19.72 | 13.92 | 33 | 34959 | 7316 | 29532219 |
BK virus infection | 19.64 | 13.92 | 26 | 34966 | 4681 | 29534854 |
Scintillating scotoma | 19.61 | 13.92 | 5 | 34987 | 26 | 29539509 |
Neuroendocrine carcinoma of the skin | 19.52 | 13.92 | 11 | 34981 | 609 | 29538926 |
Peptic ulcer haemorrhage | 19.49 | 13.92 | 10 | 34982 | 458 | 29539077 |
Syncope | 19.48 | 13.92 | 42 | 34950 | 81329 | 29458206 |
Delirium | 19.29 | 13.92 | 95 | 34897 | 39302 | 29500233 |
Psoriasis | 19.28 | 13.92 | 7 | 34985 | 32220 | 29507315 |
Cytomegalovirus enterocolitis | 19.25 | 13.92 | 12 | 34980 | 801 | 29538734 |
Acute lymphocytic leukaemia recurrent | 19.20 | 13.92 | 19 | 34973 | 2497 | 29537038 |
Inhibitory drug interaction | 19.06 | 13.92 | 15 | 34977 | 1455 | 29538080 |
Cerebral artery embolism | 19.02 | 13.92 | 12 | 34980 | 818 | 29538717 |
Cerebral fungal infection | 18.99 | 13.92 | 8 | 34984 | 232 | 29539303 |
Burns first degree | 18.93 | 13.92 | 4 | 34988 | 7 | 29539528 |
Staphylococcal sepsis | 18.90 | 13.92 | 36 | 34956 | 8826 | 29530709 |
Hospitalisation | 18.85 | 13.92 | 16 | 34976 | 45972 | 29493563 |
Bacterial infection | 18.82 | 13.92 | 45 | 34947 | 12903 | 29526632 |
Colour blindness acquired | 18.77 | 13.92 | 6 | 34986 | 77 | 29539458 |
Eye abscess | 18.72 | 13.92 | 7 | 34985 | 147 | 29539388 |
Abdominal pain upper | 18.65 | 13.92 | 27 | 34965 | 60966 | 29478569 |
Abdominal pain | 18.35 | 13.92 | 90 | 34902 | 135267 | 29404268 |
Aspartate aminotransferase | 18.30 | 13.92 | 6 | 34986 | 84 | 29539451 |
Mucosal ulceration | 18.28 | 13.92 | 12 | 34980 | 876 | 29538659 |
Organising pneumonia | 18.22 | 13.92 | 26 | 34966 | 5022 | 29534513 |
Bacterial sepsis | 18.13 | 13.92 | 25 | 34967 | 4678 | 29534857 |
Loss of personal independence in daily activities | 18.04 | 13.92 | 4 | 34988 | 25436 | 29514099 |
Nephrolithiasis | 17.93 | 13.92 | 4 | 34988 | 25330 | 29514205 |
Retinal toxicity | 17.90 | 13.92 | 9 | 34983 | 395 | 29539140 |
Flushing | 17.85 | 13.92 | 6 | 34986 | 28986 | 29510549 |
Decreased appetite | 17.83 | 13.92 | 100 | 34892 | 145242 | 29394293 |
Malignant neoplasm progression | 17.78 | 13.92 | 38 | 34954 | 73821 | 29465714 |
Neurological decompensation | 17.70 | 13.92 | 18 | 34974 | 2444 | 29537091 |
Fibrinous bronchitis | 17.69 | 13.92 | 4 | 34988 | 11 | 29539524 |
Mycotic endophthalmitis | 17.66 | 13.92 | 5 | 34987 | 41 | 29539494 |
Arthritis | 17.61 | 13.92 | 4 | 34988 | 25015 | 29514520 |
Blood bilirubin increased | 17.50 | 13.92 | 83 | 34909 | 33810 | 29505725 |
Retinal haemorrhage | 17.45 | 13.92 | 24 | 34968 | 4480 | 29535055 |
Oral papilloma | 17.43 | 13.92 | 4 | 34988 | 12 | 29539523 |
Hyperammonaemia | 17.34 | 13.92 | 27 | 34965 | 5636 | 29533899 |
Bronchial artery embolisation | 17.22 | 13.92 | 3 | 34989 | 0 | 29539535 |
Chronic obstructive pulmonary disease | 17.09 | 13.92 | 14 | 34978 | 40941 | 29498594 |
Gastrointestinal mucormycosis | 16.91 | 13.92 | 6 | 34986 | 108 | 29539427 |
Wrong technique in product usage process | 16.91 | 13.92 | 8 | 34984 | 31420 | 29508115 |
Escherichia sepsis | 16.76 | 13.92 | 22 | 34970 | 3927 | 29535608 |
Periostosis | 16.75 | 13.92 | 4 | 34988 | 15 | 29539520 |
Transplant rejection | 16.74 | 13.92 | 35 | 34957 | 9177 | 29530358 |
Hypokalaemia | 16.61 | 13.92 | 109 | 34883 | 50094 | 29489441 |
Hypersensitivity | 16.59 | 13.92 | 23 | 34969 | 52880 | 29486655 |
Gastrointestinal wall thinning | 16.54 | 13.92 | 4 | 34988 | 16 | 29539519 |
Pneumonia bacterial | 16.40 | 13.92 | 35 | 34957 | 9308 | 29530227 |
Complications of transplant surgery | 16.37 | 13.92 | 9 | 34983 | 475 | 29539060 |
Graft versus host disease in lung | 16.08 | 13.92 | 9 | 34983 | 492 | 29539043 |
Granulomatous dermatitis | 15.95 | 13.92 | 7 | 34985 | 225 | 29539310 |
Weight increased | 15.65 | 13.92 | 43 | 34949 | 76624 | 29462911 |
Hepatitis toxic | 15.61 | 13.92 | 15 | 34977 | 1901 | 29537634 |
Candida test positive | 15.54 | 13.92 | 8 | 34984 | 369 | 29539166 |
Lip ulceration | 15.48 | 13.92 | 10 | 34982 | 710 | 29538825 |
Solar dermatitis | 15.45 | 13.92 | 5 | 34987 | 67 | 29539468 |
Malabsorption | 15.40 | 13.92 | 15 | 34977 | 1933 | 29537602 |
Overdose | 15.39 | 13.92 | 46 | 34946 | 79773 | 29459762 |
Gastrointestinal wall thickening | 15.32 | 13.92 | 12 | 34980 | 1156 | 29538379 |
Chondritis | 15.30 | 13.92 | 6 | 34986 | 144 | 29539391 |
International normalised ratio increased | 15.25 | 13.92 | 18 | 34974 | 44354 | 29495181 |
Necrotising ulcerative gingivostomatitis | 15.25 | 13.92 | 5 | 34987 | 70 | 29539465 |
Chronic granulomatous disease | 15.21 | 13.92 | 4 | 34988 | 24 | 29539511 |
Donor leukocyte infusion | 15.21 | 13.92 | 4 | 34988 | 24 | 29539511 |
Haemoptysis | 15.19 | 13.92 | 74 | 34918 | 30476 | 29509059 |
Mental disorder due to a general medical condition | 15.19 | 13.92 | 6 | 34986 | 147 | 29539388 |
Chronic pulmonary histoplasmosis | 15.15 | 13.92 | 3 | 34989 | 3 | 29539532 |
Deep vein thrombosis | 15.13 | 13.92 | 28 | 34964 | 57371 | 29482164 |
Therapeutic product effect decreased | 15.08 | 13.92 | 8 | 34984 | 29443 | 29510092 |
Renal failure | 15.06 | 13.92 | 210 | 34782 | 118389 | 29421146 |
Apraxia | 15.05 | 13.92 | 12 | 34980 | 1186 | 29538349 |
Brain herniation | 15.05 | 13.92 | 20 | 34972 | 3613 | 29535922 |
Sinusitis fungal | 15.02 | 13.92 | 8 | 34984 | 396 | 29539139 |
Oropharyngeal pain | 14.93 | 13.92 | 8 | 34984 | 29277 | 29510258 |
Ephelides | 14.93 | 13.92 | 5 | 34987 | 75 | 29539460 |
Swelling | 14.80 | 13.92 | 12 | 34980 | 35271 | 29504264 |
Pneumonia cytomegaloviral | 14.71 | 13.92 | 17 | 34975 | 2665 | 29536870 |
Thrombotic microangiopathy | 14.64 | 13.92 | 32 | 34960 | 8649 | 29530886 |
Hypoxia | 14.55 | 13.92 | 101 | 34891 | 47278 | 29492257 |
Fungal skin infection | 14.52 | 13.92 | 16 | 34976 | 2382 | 29537153 |
Insomnia | 14.48 | 13.92 | 55 | 34937 | 88706 | 29450829 |
Urinary retention | 14.47 | 13.92 | 10 | 34982 | 31888 | 29507647 |
Hepatic cytolysis | 14.34 | 13.92 | 31 | 34961 | 8316 | 29531219 |
Skin mass | 14.34 | 13.92 | 19 | 34973 | 3424 | 29536111 |
Dry mouth | 14.33 | 13.92 | 4 | 34988 | 21780 | 29517755 |
Wheezing | 14.33 | 13.92 | 11 | 34981 | 33229 | 29506306 |
Atypical mycobacterial lower respiratory tract infection | 14.32 | 13.92 | 4 | 34988 | 31 | 29539504 |
Leukaemia | 14.31 | 13.92 | 20 | 34972 | 3790 | 29535745 |
Product use issue | 14.26 | 13.92 | 107 | 34885 | 51337 | 29488198 |
Systemic candida | 14.22 | 13.92 | 17 | 34975 | 2763 | 29536772 |
Hepatomegaly | 14.21 | 13.92 | 33 | 34959 | 9284 | 29530251 |
Somnolence | 14.20 | 13.92 | 60 | 34932 | 93895 | 29445640 |
Coagulopathy | 14.13 | 13.92 | 50 | 34942 | 17857 | 29521678 |
Steatohepatitis | 14.10 | 13.92 | 7 | 34985 | 299 | 29539236 |
Loss of consciousness | 14.04 | 13.92 | 43 | 34949 | 74013 | 29465522 |
Antithrombin III deficiency | 14.04 | 13.92 | 5 | 34987 | 91 | 29539444 |
Unevaluable event | 14.02 | 13.92 | 9 | 34983 | 29842 | 29509693 |
Transient ischaemic attack | 14.01 | 13.92 | 5 | 34987 | 23265 | 29516270 |
Neck pain | 13.99 | 13.92 | 4 | 34988 | 21443 | 29518092 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug interaction | 909.18 | 13.96 | 1284 | 51249 | 360799 | 64085400 |
Photosensitivity reaction | 804.83 | 13.96 | 360 | 52173 | 17813 | 64428386 |
Bronchopulmonary aspergillosis | 731.72 | 13.96 | 342 | 52191 | 18743 | 64427456 |
Drug level increased | 676.36 | 13.96 | 393 | 52140 | 33803 | 64412396 |
Aspergillus infection | 676.22 | 13.96 | 309 | 52224 | 16070 | 64430129 |
Mucormycosis | 667.49 | 13.96 | 244 | 52289 | 7097 | 64439102 |
Periostitis | 645.20 | 13.96 | 136 | 52397 | 401 | 64445798 |
Actinic keratosis | 542.31 | 13.96 | 191 | 52342 | 4974 | 64441225 |
Drug ineffective | 483.85 | 13.96 | 1637 | 50896 | 838610 | 63607589 |
Multiple organ dysfunction syndrome | 463.01 | 13.96 | 488 | 52045 | 100925 | 64345274 |
Cerebral aspergillosis | 360.10 | 13.96 | 107 | 52426 | 1586 | 64444613 |
Squamous cell carcinoma of skin | 356.21 | 13.96 | 180 | 52353 | 11696 | 64434503 |
Drug resistance | 340.87 | 13.96 | 259 | 52274 | 34843 | 64411356 |
Septic shock | 311.55 | 13.96 | 406 | 52127 | 105031 | 64341168 |
Hallucination, visual | 309.86 | 13.96 | 223 | 52310 | 27611 | 64418588 |
Fatigue | 278.01 | 13.96 | 132 | 52401 | 748598 | 63697601 |
Hallucination | 274.39 | 13.96 | 317 | 52216 | 72471 | 64373728 |
Respiratory failure | 273.44 | 13.96 | 479 | 52054 | 160704 | 64285495 |
Drug level below therapeutic | 263.47 | 13.96 | 126 | 52407 | 7258 | 64438941 |
Fungal infection | 248.21 | 13.96 | 213 | 52320 | 34038 | 64412161 |
Pathogen resistance | 244.75 | 13.96 | 143 | 52390 | 12400 | 64433799 |
Graft versus host disease | 242.22 | 13.96 | 147 | 52386 | 13666 | 64432533 |
Photodermatosis | 241.50 | 13.96 | 68 | 52465 | 823 | 64445376 |
Squamous cell carcinoma | 234.00 | 13.96 | 144 | 52389 | 13725 | 64432474 |
Systemic mycosis | 232.79 | 13.96 | 83 | 52450 | 2240 | 64443959 |
Febrile neutropenia | 222.02 | 13.96 | 479 | 52054 | 187178 | 64259021 |
Hepatotoxicity | 218.11 | 13.96 | 212 | 52321 | 39750 | 64406449 |
Pneumonia fungal | 216.06 | 13.96 | 117 | 52416 | 8760 | 64437439 |
Cholestasis | 195.77 | 13.96 | 211 | 52322 | 44661 | 64401538 |
Drug level decreased | 192.95 | 13.96 | 119 | 52414 | 11384 | 64434815 |
Scedosporium infection | 189.53 | 13.96 | 61 | 52472 | 1193 | 64445006 |
Pain | 186.77 | 13.96 | 110 | 52423 | 553401 | 63892798 |
Fluoride increased | 174.45 | 13.96 | 34 | 52499 | 57 | 64446142 |
Visual impairment | 150.64 | 13.96 | 239 | 52294 | 73838 | 64372361 |
Acute myeloid leukaemia | 148.53 | 13.96 | 145 | 52388 | 27318 | 64418881 |
Hepatic function abnormal | 142.65 | 13.96 | 216 | 52317 | 64097 | 64382102 |
Choroiditis | 140.59 | 13.96 | 47 | 52486 | 1040 | 64445159 |
Fall | 138.80 | 13.96 | 84 | 52449 | 416742 | 64029457 |
Solar lentigo | 133.12 | 13.96 | 43 | 52490 | 851 | 64445348 |
Fungaemia | 121.22 | 13.96 | 60 | 52473 | 3725 | 64442474 |
Fluorosis | 114.80 | 13.96 | 24 | 52509 | 67 | 64446132 |
Immunosuppressant drug level increased | 113.93 | 13.96 | 72 | 52461 | 7187 | 64439012 |
Rheumatoid arthritis | 109.34 | 13.96 | 6 | 52527 | 164288 | 64281911 |
Product use in unapproved indication | 109.06 | 13.96 | 354 | 52179 | 176264 | 64269935 |
Candida infection | 108.62 | 13.96 | 131 | 52402 | 31288 | 64414911 |
Arthralgia | 106.67 | 13.96 | 122 | 52411 | 442138 | 64004061 |
Joint swelling | 101.93 | 13.96 | 25 | 52508 | 215357 | 64230842 |
Neurotoxicity | 99.24 | 13.96 | 117 | 52416 | 27287 | 64418912 |
Product dose omission issue | 97.39 | 13.96 | 20 | 52513 | 194727 | 64251472 |
Graft versus host disease in gastrointestinal tract | 96.51 | 13.96 | 59 | 52474 | 5553 | 64440646 |
Pruritus | 95.73 | 13.96 | 69 | 52464 | 312331 | 64133868 |
Venoocclusive liver disease | 95.18 | 13.96 | 73 | 52460 | 9942 | 64436257 |
Dizziness | 93.95 | 13.96 | 128 | 52405 | 430035 | 64016164 |
Nausea | 93.02 | 13.96 | 329 | 52204 | 785471 | 63660728 |
Fusarium infection | 92.20 | 13.96 | 38 | 52495 | 1531 | 64444668 |
Pseudomonas infection | 92.19 | 13.96 | 92 | 52441 | 17791 | 64428408 |
Condition aggravated | 91.67 | 13.96 | 567 | 51966 | 371859 | 64074340 |
Dysplastic naevus | 90.38 | 13.96 | 28 | 52505 | 481 | 64445718 |
Dyschromatopsia | 89.22 | 13.96 | 30 | 52503 | 676 | 64445523 |
Nasopharyngitis | 88.51 | 13.96 | 25 | 52508 | 196048 | 64250151 |
Hepatocellular injury | 87.88 | 13.96 | 143 | 52390 | 45092 | 64401107 |
Pain in extremity | 87.68 | 13.96 | 71 | 52462 | 303014 | 64143185 |
Disseminated mucormycosis | 86.24 | 13.96 | 27 | 52506 | 481 | 64445718 |
Drug hypersensitivity | 86.19 | 13.96 | 43 | 52490 | 237772 | 64208427 |
Drug level above therapeutic | 85.36 | 13.96 | 59 | 52474 | 6842 | 64439357 |
Cheilitis | 85.36 | 13.96 | 51 | 52482 | 4605 | 64441594 |
Peripheral swelling | 85.03 | 13.96 | 32 | 52501 | 209121 | 64237078 |
Drug abuse | 84.58 | 13.96 | 6 | 52527 | 132368 | 64313831 |
Pneumonia | 82.20 | 13.96 | 754 | 51779 | 558822 | 63887377 |
Headache | 80.42 | 13.96 | 197 | 52336 | 529270 | 63916929 |
Dilatation intrahepatic duct acquired | 77.96 | 13.96 | 27 | 52506 | 667 | 64445532 |
Nephropathy toxic | 77.48 | 13.96 | 83 | 52450 | 17431 | 64428768 |
Pancytopenia | 75.07 | 13.96 | 272 | 52261 | 143037 | 64303162 |
Hypertrophic osteoarthropathy | 74.97 | 13.96 | 18 | 52515 | 109 | 64446090 |
Brain abscess | 74.58 | 13.96 | 45 | 52488 | 4136 | 64442063 |
Injection site pain | 74.33 | 13.96 | 4 | 52529 | 111404 | 64334795 |
Drug ineffective for unapproved indication | 73.92 | 13.96 | 108 | 52425 | 31025 | 64415174 |
Pulmonary mucormycosis | 73.82 | 13.96 | 27 | 52506 | 785 | 64445414 |
Arthropathy | 73.09 | 13.96 | 7 | 52526 | 120960 | 64325239 |
Diarrhoea | 73.07 | 13.96 | 322 | 52211 | 722382 | 63723817 |
Enterococcal infection | 72.70 | 13.96 | 72 | 52461 | 13794 | 64432405 |
Pyrexia | 72.27 | 13.96 | 733 | 51800 | 557911 | 63888288 |
Myocardial infarction | 71.46 | 13.96 | 23 | 52510 | 165798 | 64280401 |
Blood pressure increased | 70.79 | 13.96 | 26 | 52507 | 172526 | 64273673 |
Hypersensitivity | 70.45 | 13.96 | 36 | 52497 | 196416 | 64249783 |
Anxiety | 69.94 | 13.96 | 39 | 52494 | 202610 | 64243589 |
Aspergillus test positive | 69.82 | 13.96 | 25 | 52508 | 683 | 64445516 |
Musculoskeletal stiffness | 69.73 | 13.96 | 9 | 52524 | 123197 | 64323002 |
Torsade de pointes | 69.37 | 13.96 | 78 | 52455 | 17285 | 64428914 |
Acute respiratory distress syndrome | 68.83 | 13.96 | 118 | 52415 | 38817 | 64407382 |
Leukaemia recurrent | 68.20 | 13.96 | 36 | 52497 | 2558 | 64443641 |
Blood alkaline phosphatase increased | 67.92 | 13.96 | 145 | 52388 | 56134 | 64390065 |
Cytomegalovirus viraemia | 67.76 | 13.96 | 62 | 52471 | 10766 | 64435433 |
Swelling | 67.68 | 13.96 | 23 | 52510 | 160195 | 64286004 |
Cytomegalovirus infection | 67.43 | 13.96 | 114 | 52419 | 37085 | 64409114 |
Urinary tract infection | 67.26 | 13.96 | 54 | 52479 | 231542 | 64214657 |
Visual acuity reduced | 67.13 | 13.96 | 96 | 52437 | 27045 | 64419154 |
Treatment failure | 66.57 | 13.96 | 228 | 52305 | 116588 | 64329611 |
Dyspnoea | 65.13 | 13.96 | 333 | 52200 | 718341 | 63727858 |
Liver disorder | 65.01 | 13.96 | 138 | 52395 | 53213 | 64392986 |
Acute graft versus host disease | 64.77 | 13.96 | 56 | 52477 | 9028 | 64437171 |
Malaise | 64.47 | 13.96 | 142 | 52391 | 396105 | 64050094 |
Graft versus host disease in skin | 64.46 | 13.96 | 45 | 52488 | 5302 | 64440897 |
Lentigo | 64.29 | 13.96 | 21 | 52512 | 431 | 64445768 |
Acute graft versus host disease in liver | 63.89 | 13.96 | 30 | 52503 | 1657 | 64444542 |
Off label use | 63.52 | 13.96 | 790 | 51743 | 632016 | 63814183 |
Neutropenia | 62.13 | 13.96 | 370 | 52163 | 239254 | 64206945 |
Fungal endocarditis | 62.05 | 13.96 | 21 | 52512 | 483 | 64445716 |
Sepsis | 61.87 | 13.96 | 359 | 52174 | 229982 | 64216217 |
Asthenia | 60.52 | 13.96 | 165 | 52368 | 427879 | 64018320 |
Synovitis | 59.17 | 13.96 | 6 | 52527 | 99084 | 64347115 |
Nervous system disorder | 59.11 | 13.96 | 83 | 52450 | 22995 | 64423204 |
Abdominal discomfort | 57.47 | 13.96 | 39 | 52494 | 182283 | 64263916 |
Therapeutic product effect decreased | 57.32 | 13.96 | 12 | 52521 | 115339 | 64330860 |
Blood bilirubin increased | 56.88 | 13.96 | 137 | 52396 | 57416 | 64388783 |
Contraindicated product administered | 56.16 | 13.96 | 10 | 52523 | 107819 | 64338380 |
Back pain | 54.97 | 13.96 | 74 | 52459 | 250097 | 64196102 |
Halo vision | 54.89 | 13.96 | 20 | 52513 | 575 | 64445624 |
Chest pain | 54.74 | 13.96 | 67 | 52466 | 235913 | 64210286 |
Xanthopsia | 54.66 | 13.96 | 17 | 52516 | 296 | 64445903 |
Acute graft versus host disease in skin | 54.51 | 13.96 | 45 | 52488 | 6810 | 64439389 |
Drug-induced liver injury | 53.22 | 13.96 | 119 | 52414 | 47524 | 64398675 |
Photophobia | 53.17 | 13.96 | 68 | 52465 | 17225 | 64428974 |
Phaeohyphomycosis | 53.07 | 13.96 | 23 | 52510 | 1051 | 64445148 |
Endophthalmitis | 52.95 | 13.96 | 40 | 52493 | 5325 | 64440874 |
Delirium | 52.30 | 13.96 | 149 | 52384 | 69045 | 64377154 |
Infusion related reaction | 52.07 | 13.96 | 35 | 52498 | 164432 | 64281767 |
Maternal exposure during pregnancy | 51.92 | 13.96 | 8 | 52525 | 95876 | 64350323 |
Chronic graft versus host disease | 51.58 | 13.96 | 42 | 52491 | 6234 | 64439965 |
Product compounding quality issue | 51.31 | 13.96 | 11 | 52522 | 36 | 64446163 |
Hepatitis cholestatic | 50.96 | 13.96 | 56 | 52477 | 12099 | 64434100 |
Intraocular pressure increased | 50.90 | 13.96 | 47 | 52486 | 8255 | 64437944 |
Septic embolus | 50.76 | 13.96 | 26 | 52507 | 1736 | 64444463 |
Weight increased | 50.09 | 13.96 | 60 | 52473 | 213288 | 64232911 |
Geotrichum infection | 49.79 | 13.96 | 21 | 52512 | 897 | 64445302 |
Acute graft versus host disease in intestine | 49.75 | 13.96 | 33 | 52500 | 3576 | 64442623 |
Disseminated intravascular coagulation | 49.43 | 13.96 | 92 | 52441 | 32256 | 64413943 |
Mediastinitis | 48.92 | 13.96 | 20 | 52513 | 789 | 64445410 |
Gamma-glutamyltransferase increased | 48.50 | 13.96 | 116 | 52417 | 48394 | 64397805 |
Urticaria | 48.48 | 13.96 | 30 | 52503 | 147287 | 64298912 |
Exposure during pregnancy | 48.25 | 13.96 | 4 | 52529 | 77671 | 64368528 |
Systemic lupus erythematosus | 48.21 | 13.96 | 4 | 52529 | 77608 | 64368591 |
Discomfort | 48.02 | 13.96 | 5 | 52528 | 80873 | 64365326 |
Lower respiratory tract infection fungal | 47.85 | 13.96 | 20 | 52513 | 835 | 64445364 |
Arthritis | 47.71 | 13.96 | 6 | 52527 | 83808 | 64362391 |
Pneumonia bacterial | 47.62 | 13.96 | 60 | 52473 | 14975 | 64431224 |
Dyspepsia | 47.59 | 13.96 | 5 | 52528 | 80307 | 64365892 |
Staphylococcal infection | 47.28 | 13.96 | 118 | 52415 | 50560 | 64395639 |
Aspergilloma | 47.11 | 13.96 | 17 | 52516 | 475 | 64445724 |
Stenotrophomonas infection | 46.96 | 13.96 | 30 | 52503 | 3050 | 64443149 |
Pulmonary alveolar haemorrhage | 46.36 | 13.96 | 48 | 52485 | 9690 | 64436509 |
Central nervous system fungal infection | 45.80 | 13.96 | 16 | 52517 | 406 | 64445793 |
Abdominal pain upper | 45.76 | 13.96 | 45 | 52488 | 174985 | 64271214 |
Fungal test positive | 45.40 | 13.96 | 20 | 52513 | 951 | 64445248 |
Transaminases increased | 44.98 | 13.96 | 107 | 52426 | 44487 | 64401712 |
Gastrooesophageal reflux disease | 44.87 | 13.96 | 7 | 52526 | 83136 | 64363063 |
Cytokine release syndrome | 44.80 | 13.96 | 69 | 52464 | 20760 | 64425439 |
Immunosuppressant drug level decreased | 44.38 | 13.96 | 24 | 52509 | 1791 | 64444408 |
Neurological symptom | 44.31 | 13.96 | 40 | 52493 | 6824 | 64439375 |
Trichosporon infection | 43.74 | 13.96 | 19 | 52514 | 873 | 64445326 |
Nocardiosis | 43.67 | 13.96 | 34 | 52499 | 4733 | 64441466 |
Post transplant lymphoproliferative disorder | 43.57 | 13.96 | 46 | 52487 | 9498 | 64436701 |
Haemophagocytic lymphohistiocytosis | 43.13 | 13.96 | 62 | 52471 | 17547 | 64428652 |
Injection site erythema | 43.02 | 13.96 | 4 | 52529 | 70796 | 64375403 |
Skin candida | 42.98 | 13.96 | 23 | 52510 | 1680 | 64444519 |
Vomiting | 42.97 | 13.96 | 268 | 52265 | 550849 | 63895350 |
Alopecia | 42.85 | 13.96 | 43 | 52490 | 165647 | 64280552 |
Rash | 42.83 | 13.96 | 210 | 52323 | 458339 | 63987860 |
Hepatic cytolysis | 42.81 | 13.96 | 55 | 52478 | 13994 | 64432205 |
Altered state of consciousness | 42.70 | 13.96 | 95 | 52438 | 37807 | 64408392 |
Inappropriate antidiuretic hormone secretion | 42.65 | 13.96 | 70 | 52463 | 22219 | 64423980 |
Toxic optic neuropathy | 42.65 | 13.96 | 19 | 52514 | 928 | 64445271 |
Electrocardiogram QT prolonged | 42.59 | 13.96 | 152 | 52381 | 79296 | 64366903 |
Uveitis | 42.31 | 13.96 | 52 | 52481 | 12656 | 64433543 |
Acute myeloid leukaemia recurrent | 42.16 | 13.96 | 27 | 52506 | 2757 | 64443442 |
Klebsiella infection | 42.06 | 13.96 | 53 | 52480 | 13228 | 64432971 |
Pseudoporphyria | 41.89 | 13.96 | 16 | 52517 | 526 | 64445673 |
Intentional overdose | 41.44 | 13.96 | 11 | 52522 | 89933 | 64356266 |
Cerebral fungal infection | 41.24 | 13.96 | 14 | 52519 | 325 | 64445874 |
Infective aneurysm | 40.78 | 13.96 | 18 | 52515 | 860 | 64445339 |
Product contamination microbial | 40.68 | 13.96 | 18 | 52515 | 865 | 64445334 |
Osteoarthritis | 40.08 | 13.96 | 3 | 52530 | 63333 | 64382866 |
Wound | 40.02 | 13.96 | 7 | 52526 | 76470 | 64369729 |
Encephalopathy | 40 | 13.96 | 122 | 52411 | 58697 | 64387502 |
Acute lymphocytic leukaemia | 39.66 | 13.96 | 31 | 52502 | 4340 | 64441859 |
Pneumothorax | 39.52 | 13.96 | 71 | 52462 | 24227 | 64421972 |
Depression | 39.45 | 13.96 | 55 | 52478 | 183236 | 64262963 |
Inappropriate schedule of product administration | 39.39 | 13.96 | 13 | 52520 | 92273 | 64353926 |
Cystitis haemorrhagic | 39.30 | 13.96 | 40 | 52493 | 7916 | 64438283 |
Renal impairment | 39.22 | 13.96 | 215 | 52318 | 134802 | 64311397 |
Contusion | 39.20 | 13.96 | 22 | 52511 | 113943 | 64332256 |
Thrombotic microangiopathy | 38.41 | 13.96 | 57 | 52476 | 16598 | 64429601 |
Systemic candida | 38.29 | 13.96 | 33 | 52500 | 5296 | 64440903 |
Impaired healing | 37.88 | 13.96 | 3 | 52530 | 60470 | 64385729 |
Lung infiltration | 37.83 | 13.96 | 64 | 52469 | 20825 | 64425374 |
Flushing | 37.42 | 13.96 | 9 | 52524 | 78639 | 64367560 |
Enterococcal sepsis | 37.30 | 13.96 | 24 | 52509 | 2470 | 64443729 |
Renal ischaemia | 37.17 | 13.96 | 18 | 52515 | 1065 | 64445134 |
Chromatopsia | 37.12 | 13.96 | 15 | 52518 | 574 | 64445625 |
Abscess fungal | 36.89 | 13.96 | 12 | 52521 | 243 | 64445956 |
Chloropsia | 36.68 | 13.96 | 6 | 52527 | 0 | 64446199 |
Macular opacity | 36.68 | 13.96 | 6 | 52527 | 0 | 64446199 |
Infectious pleural effusion | 36.65 | 13.96 | 25 | 52508 | 2837 | 64443362 |
Platelet count decreased | 36.62 | 13.96 | 248 | 52285 | 167463 | 64278736 |
Scopulariopsis infection | 36.46 | 13.96 | 10 | 52523 | 109 | 64446090 |
Renal failure | 36.35 | 13.96 | 263 | 52270 | 181425 | 64264774 |
Transmission of an infectious agent via product | 36.17 | 13.96 | 11 | 52522 | 177 | 64446022 |
Weight decreased | 36.09 | 13.96 | 116 | 52417 | 285623 | 64160576 |
Osteomyelitis fungal | 36.00 | 13.96 | 12 | 52521 | 263 | 64445936 |
Acute lymphocytic leukaemia recurrent | 35.34 | 13.96 | 28 | 52505 | 3998 | 64442201 |
Hypokalaemia | 35.32 | 13.96 | 194 | 52339 | 121709 | 64324490 |
Neutrophil count decreased | 35.00 | 13.96 | 140 | 52393 | 77056 | 64369143 |
Scintillating scotoma | 34.97 | 13.96 | 11 | 52522 | 199 | 64446000 |
Constipation | 34.97 | 13.96 | 85 | 52448 | 229252 | 64216947 |
Eye abscess | 34.74 | 13.96 | 12 | 52521 | 294 | 64445905 |
Abdominal pain | 34.01 | 13.96 | 135 | 52398 | 312240 | 64133959 |
Rectal haemorrhage | 33.82 | 13.96 | 5 | 52528 | 61812 | 64384387 |
Muscle spasms | 33.79 | 13.96 | 39 | 52494 | 140984 | 64305215 |
Cardiac failure congestive | 33.63 | 13.96 | 34 | 52499 | 130546 | 64315653 |
Palpitations | 33.38 | 13.96 | 22 | 52511 | 104466 | 64341733 |
Pulmonary haemorrhage | 33.35 | 13.96 | 47 | 52486 | 13062 | 64433137 |
Basal cell carcinoma | 33.29 | 13.96 | 76 | 52457 | 30762 | 64415437 |
Sunburn | 33.23 | 13.96 | 25 | 52508 | 3307 | 64442892 |
Sinusitis | 33.22 | 13.96 | 42 | 52491 | 145886 | 64300313 |
Loss of personal independence in daily activities | 33.11 | 13.96 | 9 | 52524 | 72445 | 64373754 |
Stress | 32.88 | 13.96 | 5 | 52528 | 60529 | 64385670 |
Graft versus host disease in lung | 32.63 | 13.96 | 15 | 52518 | 789 | 64445410 |
Psoriasis | 32.59 | 13.96 | 9 | 52524 | 71694 | 64374505 |
BK virus infection | 32.56 | 13.96 | 35 | 52498 | 7377 | 64438822 |
Disease progression | 32.43 | 13.96 | 212 | 52321 | 141468 | 64304731 |
Oropharyngeal pain | 32.26 | 13.96 | 16 | 52517 | 88851 | 64357348 |
Migraine | 32.22 | 13.96 | 6 | 52527 | 62671 | 64383528 |
Disseminated aspergillosis | 32.01 | 13.96 | 14 | 52519 | 654 | 64445545 |
Cerebrovascular accident | 31.95 | 13.96 | 39 | 52494 | 137544 | 64308655 |
Mobility decreased | 31.86 | 13.96 | 15 | 52518 | 85825 | 64360374 |
Myoclonus | 31.78 | 13.96 | 66 | 52467 | 25052 | 64421147 |
Leukaemia | 31.57 | 13.96 | 29 | 52504 | 5059 | 64441140 |
Hypertension | 31.53 | 13.96 | 107 | 52426 | 259154 | 64187045 |
Photopsia | 31.48 | 13.96 | 28 | 52505 | 4686 | 64441513 |
Fungal skin infection | 31.39 | 13.96 | 29 | 52504 | 5096 | 64441103 |
Liver function test abnormal | 31.28 | 13.96 | 113 | 52420 | 59288 | 64386911 |
Bone marrow failure | 31.25 | 13.96 | 98 | 52435 | 47854 | 64398345 |
Arthritis fungal | 31.16 | 13.96 | 9 | 52524 | 120 | 64446079 |
Posterior reversible encephalopathy syndrome | 31.06 | 13.96 | 62 | 52471 | 22884 | 64423315 |
Bacterial infection | 30.92 | 13.96 | 65 | 52468 | 24885 | 64421314 |
Aplasia | 30.83 | 13.96 | 33 | 52500 | 6920 | 64439279 |
Haemoptysis | 30.83 | 13.96 | 99 | 52434 | 48949 | 64397250 |
Bacterial sepsis | 30.64 | 13.96 | 34 | 52499 | 7423 | 64438776 |
Toxoplasmosis | 30.47 | 13.96 | 21 | 52512 | 2423 | 64443776 |
Pulmonary embolism | 30.42 | 13.96 | 45 | 52488 | 146311 | 64299888 |
Alternaria infection | 30.40 | 13.96 | 13 | 52520 | 575 | 64445624 |
Eye infection fungal | 30.21 | 13.96 | 12 | 52521 | 439 | 64445760 |
Lip squamous cell carcinoma | 29.75 | 13.96 | 10 | 52523 | 225 | 64445974 |
Syncope | 29.45 | 13.96 | 52 | 52481 | 157583 | 64288616 |
Gastrointestinal mucormycosis | 29.41 | 13.96 | 11 | 52522 | 341 | 64445858 |
Neck pain | 29.36 | 13.96 | 7 | 52526 | 61526 | 64384673 |
Mycobacterium abscessus infection | 29.32 | 13.96 | 15 | 52518 | 999 | 64445200 |
Blood pressure fluctuation | 28.83 | 13.96 | 4 | 52529 | 51867 | 64394332 |
Corneal perforation | 28.51 | 13.96 | 13 | 52520 | 671 | 64445528 |
Toxic skin eruption | 28.41 | 13.96 | 54 | 52479 | 19230 | 64426969 |
Hyperhidrosis | 28.38 | 13.96 | 36 | 52497 | 124884 | 64321315 |
Lung transplant rejection | 28.15 | 13.96 | 16 | 52517 | 1316 | 64444883 |
Cytomegalovirus enterocolitis | 27.89 | 13.96 | 16 | 52517 | 1339 | 64444860 |
Aspergillus test | 27.68 | 13.96 | 6 | 52527 | 21 | 64446178 |
Colour blindness acquired | 27.54 | 13.96 | 8 | 52525 | 109 | 64446090 |
Burns second degree | 27.45 | 13.96 | 14 | 52519 | 926 | 64445273 |
Hyperammonaemia | 27.43 | 13.96 | 37 | 52496 | 9867 | 64436332 |
Hallucinations, mixed | 27.33 | 13.96 | 29 | 52504 | 6023 | 64440176 |
Chest discomfort | 26.86 | 13.96 | 33 | 52500 | 116073 | 64330126 |
Dry mouth | 26.69 | 13.96 | 8 | 52525 | 60410 | 64385789 |
Asthma | 26.63 | 13.96 | 23 | 52510 | 95202 | 64350997 |
Hepatic failure | 26.35 | 13.96 | 102 | 52431 | 55292 | 64390907 |
Intentional product misuse | 26.27 | 13.96 | 13 | 52520 | 72282 | 64373917 |
Graft versus host disease in liver | 25.98 | 13.96 | 16 | 52517 | 1525 | 64444674 |
Pulmonary mass | 25.71 | 13.96 | 59 | 52474 | 23957 | 64422242 |
Splenic candidiasis | 25.63 | 13.96 | 7 | 52526 | 75 | 64446124 |
Respiratory tract infection fungal | 25.48 | 13.96 | 14 | 52519 | 1078 | 64445121 |
Venoocclusive disease | 25.29 | 13.96 | 23 | 52510 | 3962 | 64442237 |
Skin mass | 25.16 | 13.96 | 30 | 52503 | 7076 | 64439123 |
Colour blindness | 24.79 | 13.96 | 10 | 52523 | 381 | 64445818 |
Transplant rejection | 24.74 | 13.96 | 48 | 52485 | 17353 | 64428846 |
Wrong technique in product usage process | 24.66 | 13.96 | 11 | 52522 | 64963 | 64381236 |
Dermatitis bullous | 24.62 | 13.96 | 39 | 52494 | 12015 | 64434184 |
Insomnia | 24.48 | 13.96 | 81 | 52452 | 197755 | 64248444 |
Ocular surface squamous neoplasia | 24.46 | 13.96 | 4 | 52529 | 0 | 64446199 |
Urinary bladder rupture | 24.40 | 13.96 | 7 | 52526 | 91 | 64446108 |
Potentiating drug interaction | 24.33 | 13.96 | 31 | 52502 | 7821 | 64438378 |
Gallbladder empyema | 24.33 | 13.96 | 7 | 52526 | 92 | 64446107 |
Feeling hot | 24.28 | 13.96 | 4 | 52529 | 45659 | 64400540 |
Mixed liver injury | 24.28 | 13.96 | 26 | 52507 | 5455 | 64440744 |
Retinal haemorrhage | 24.19 | 13.96 | 30 | 52503 | 7368 | 64438831 |
Differentiation syndrome | 24.09 | 13.96 | 17 | 52516 | 2037 | 64444162 |
Mycotic endophthalmitis | 23.92 | 13.96 | 7 | 52526 | 98 | 64446101 |
Citrobacter infection | 23.77 | 13.96 | 12 | 52521 | 777 | 64445422 |
Tongue necrosis | 23.76 | 13.96 | 6 | 52527 | 46 | 64446153 |
Central nervous system lesion | 23.74 | 13.96 | 38 | 52495 | 11811 | 64434388 |
Neuroendocrine carcinoma of the skin | 23.73 | 13.96 | 13 | 52520 | 995 | 64445204 |
Acinetobacter infection | 23.73 | 13.96 | 18 | 52515 | 2411 | 64443788 |
Acute kidney injury | 23.47 | 13.96 | 504 | 52029 | 448736 | 63997463 |
Bacteraemia | 23.37 | 13.96 | 61 | 52472 | 26850 | 64419349 |
Necrosis | 23.36 | 13.96 | 31 | 52502 | 8140 | 64438059 |
Escherichia sepsis | 23.34 | 13.96 | 29 | 52504 | 7136 | 64439063 |
Depressed mood | 23.18 | 13.96 | 3 | 52530 | 41009 | 64405190 |
Pneumonia pseudomonal | 23.04 | 13.96 | 24 | 52509 | 4879 | 64441320 |
Pain in jaw | 22.99 | 13.96 | 3 | 52530 | 40752 | 64405447 |
Primary myelofibrosis | 22.94 | 13.96 | 7 | 52526 | 114 | 64446085 |
Blood pressure systolic increased | 22.87 | 13.96 | 6 | 52527 | 49447 | 64396752 |
Lower respiratory tract infection | 22.84 | 13.96 | 26 | 52507 | 94588 | 64351611 |
Escherichia bacteraemia | 22.83 | 13.96 | 25 | 52508 | 5378 | 64440821 |
Eye pain | 22.82 | 13.96 | 67 | 52466 | 31558 | 64414641 |
Pulmonary cavitation | 22.58 | 13.96 | 14 | 52519 | 1351 | 64444848 |
Feeling abnormal | 22.40 | 13.96 | 47 | 52486 | 133555 | 64312644 |
Chronic graft versus host disease in skin | 22.33 | 13.96 | 14 | 52519 | 1377 | 64444822 |
Infection reactivation | 21.97 | 13.96 | 16 | 52517 | 2014 | 64444185 |
Strongyloidiasis | 21.93 | 13.96 | 19 | 52514 | 3071 | 64443128 |
Mucosal ulceration | 21.91 | 13.96 | 15 | 52518 | 1712 | 64444487 |
Stem cell transplant | 21.91 | 13.96 | 20 | 52513 | 3461 | 64442738 |
Blood beta-D-glucan increased | 21.90 | 13.96 | 10 | 52523 | 518 | 64445681 |
Retinal ischaemia | 21.84 | 13.96 | 11 | 52522 | 709 | 64445490 |
Dyspnoea exertional | 21.62 | 13.96 | 17 | 52516 | 73713 | 64372486 |
Coagulopathy | 21.50 | 13.96 | 66 | 52467 | 31854 | 64414345 |
Aspartate aminotransferase increased | 21.46 | 13.96 | 169 | 52364 | 119619 | 64326580 |
Blood cholesterol increased | 21.45 | 13.96 | 7 | 52526 | 50059 | 64396140 |
Granulomatous liver disease | 21.40 | 13.96 | 13 | 52520 | 1209 | 64444990 |
Anaphylactic reaction | 21.20 | 13.96 | 15 | 52518 | 68649 | 64377550 |
Procalcitonin increased | 21.17 | 13.96 | 17 | 52516 | 2474 | 64443725 |
Ileus paralytic | 21.15 | 13.96 | 30 | 52503 | 8385 | 64437814 |
Upper respiratory tract infection | 21.06 | 13.96 | 17 | 52516 | 72768 | 64373431 |
Epstein-Barr virus infection | 20.96 | 13.96 | 37 | 52496 | 12451 | 64433748 |
Organising pneumonia | 20.89 | 13.96 | 31 | 52502 | 9024 | 64437175 |
Disseminated cryptococcosis | 20.81 | 13.96 | 14 | 52519 | 1553 | 64444646 |
Pleural effusion | 20.75 | 13.96 | 175 | 52358 | 126384 | 64319815 |
Drug clearance decreased | 20.42 | 13.96 | 17 | 52516 | 2602 | 64443597 |
Necrotising retinitis | 20.42 | 13.96 | 12 | 52521 | 1051 | 64445148 |
Toxic encephalopathy | 20.39 | 13.96 | 32 | 52501 | 9783 | 64436416 |
Agranulocytosis | 20.36 | 13.96 | 73 | 52460 | 38156 | 64408043 |
Oxygen saturation decreased | 20.33 | 13.96 | 35 | 52498 | 107141 | 64339058 |
Hypoxia | 20.22 | 13.96 | 132 | 52401 | 88017 | 64358182 |
Pericarditis | 20.18 | 13.96 | 13 | 52520 | 62503 | 64383696 |
Hypertransaminasaemia | 20.12 | 13.96 | 27 | 52506 | 7164 | 64439035 |
Fungal sepsis | 20.09 | 13.96 | 14 | 52519 | 1644 | 64444555 |
Keratitis fungal | 20.02 | 13.96 | 7 | 52526 | 178 | 64446021 |
Lung consolidation | 20.01 | 13.96 | 28 | 52505 | 7730 | 64438469 |
Adenovirus infection | 19.94 | 13.96 | 27 | 52506 | 7228 | 64438971 |
Coccidioidomycosis | 19.89 | 13.96 | 12 | 52521 | 1102 | 64445097 |
Mental status changes | 19.52 | 13.96 | 100 | 52433 | 61062 | 64385137 |
Tracheobronchitis | 19.47 | 13.96 | 14 | 52519 | 1728 | 64444471 |
Organ failure | 19.29 | 13.96 | 19 | 52514 | 3614 | 64442585 |
Transient ischaemic attack | 19.25 | 13.96 | 6 | 52527 | 44176 | 64402023 |
Flatulence | 19.25 | 13.96 | 3 | 52530 | 35663 | 64410536 |
Renal disorder | 19.23 | 13.96 | 68 | 52465 | 35297 | 64410902 |
Antithrombin III deficiency | 19.05 | 13.96 | 6 | 52527 | 109 | 64446090 |
Human herpesvirus 6 infection | 18.75 | 13.96 | 21 | 52512 | 4633 | 64441566 |
Rhinovirus infection | 18.60 | 13.96 | 24 | 52509 | 6132 | 64440067 |
Infective pulmonary exacerbation of cystic fibrosis | 18.58 | 13.96 | 34 | 52499 | 11762 | 64434437 |
Nasal congestion | 18.46 | 13.96 | 13 | 52520 | 59645 | 64386554 |
Solar dermatitis | 18.39 | 13.96 | 7 | 52526 | 228 | 64445971 |
Disease recurrence | 18.36 | 13.96 | 62 | 52471 | 31448 | 64414751 |
Periostosis | 18.24 | 13.96 | 4 | 52529 | 15 | 64446184 |
Oral papilloma | 18.24 | 13.96 | 4 | 52529 | 15 | 64446184 |
Pneumonia cytomegaloviral | 18.20 | 13.96 | 20 | 52513 | 4319 | 64441880 |
Obliterative bronchiolitis | 18.13 | 13.96 | 16 | 52517 | 2649 | 64443550 |
Candida test positive | 17.76 | 13.96 | 11 | 52522 | 1059 | 64445140 |
Lung abscess | 17.74 | 13.96 | 18 | 52515 | 3548 | 64442651 |
Chronic obstructive pulmonary disease | 17.72 | 13.96 | 19 | 52514 | 71029 | 64375170 |
Mucosal inflammation | 17.71 | 13.96 | 99 | 52434 | 62485 | 64383714 |
Dehydration | 17.56 | 13.96 | 104 | 52429 | 216659 | 64229540 |
Haemodynamic instability | 17.50 | 13.96 | 38 | 52495 | 14874 | 64431325 |
Brain herniation | 17.48 | 13.96 | 24 | 52509 | 6509 | 64439690 |
Gastrointestinal wall thinning | 17.47 | 13.96 | 4 | 52529 | 19 | 64446180 |
Sinusitis fungal | 17.46 | 13.96 | 13 | 52520 | 1693 | 64444506 |
Tonsillitis bacterial | 17.45 | 13.96 | 6 | 52527 | 145 | 64446054 |
Cerebral haemorrhage | 17.34 | 13.96 | 85 | 52448 | 51005 | 64395194 |
Peptic ulcer haemorrhage | 17.28 | 13.96 | 10 | 52523 | 851 | 64445348 |
Diverticulitis | 17.27 | 13.96 | 5 | 52528 | 38613 | 64407586 |
Mental disorder due to a general medical condition | 17.25 | 13.96 | 7 | 52526 | 271 | 64445928 |
Septal panniculitis | 17.22 | 13.96 | 5 | 52528 | 68 | 64446131 |
Cystitis viral | 17.19 | 13.96 | 9 | 52524 | 629 | 64445570 |
Fibromyalgia | 17.17 | 13.96 | 4 | 52529 | 35727 | 64410472 |
Memory impairment | 17.17 | 13.96 | 27 | 52506 | 85655 | 64360544 |
Pseudallescheria infection | 17.14 | 13.96 | 4 | 52529 | 21 | 64446178 |
Brain oedema | 17.12 | 13.96 | 48 | 52485 | 22027 | 64424172 |
Acute myocardial infarction | 17.00 | 13.96 | 19 | 52514 | 69699 | 64376500 |
Musculoskeletal pain | 16.88 | 13.96 | 25 | 52508 | 81269 | 64364930 |
Hospitalisation | 16.74 | 13.96 | 22 | 52511 | 75185 | 64371014 |
Angina pectoris | 16.54 | 13.96 | 8 | 52525 | 45073 | 64401126 |
Rash maculo-papular | 16.51 | 13.96 | 79 | 52454 | 46947 | 64399252 |
Gait disturbance | 16.51 | 13.96 | 78 | 52455 | 172077 | 64274122 |
Staphylococcal bacteraemia | 16.51 | 13.96 | 30 | 52503 | 10325 | 64435874 |
Acanthamoeba infection | 16.45 | 13.96 | 8 | 52525 | 478 | 64445721 |
Hepatic candidiasis | 16.41 | 13.96 | 5 | 52528 | 81 | 64446118 |
Hallucination, auditory | 16.38 | 13.96 | 40 | 52493 | 16899 | 64429300 |
Suicidal ideation | 16.37 | 13.96 | 18 | 52515 | 66524 | 64379675 |
Chronic pulmonary histoplasmosis | 16.26 | 13.96 | 3 | 52530 | 3 | 64446196 |
Exserohilum infection | 16.26 | 13.96 | 3 | 52530 | 3 | 64446196 |
Tuberculosis gastrointestinal | 16.17 | 13.96 | 8 | 52525 | 496 | 64445703 |
Osteitis deformans | 16.13 | 13.96 | 6 | 52527 | 183 | 64446016 |
Adverse event | 16.10 | 13.96 | 6 | 52527 | 39483 | 64406716 |
Corneal bleeding | 16.04 | 13.96 | 4 | 52529 | 29 | 64446170 |
Type 2 diabetes mellitus | 15.97 | 13.96 | 4 | 52529 | 34016 | 64412183 |
Complications of transplant surgery | 15.95 | 13.96 | 9 | 52524 | 730 | 64445469 |
Bone marrow transplant | 15.91 | 13.96 | 11 | 52522 | 1276 | 64444923 |
Dysphonia | 15.88 | 13.96 | 9 | 52524 | 46373 | 64399826 |
Cerebral artery embolism | 15.85 | 13.96 | 12 | 52521 | 1602 | 64444597 |
Burns first degree | 15.80 | 13.96 | 4 | 52529 | 31 | 64446168 |
Granulomatous dermatitis | 15.77 | 13.96 | 7 | 52526 | 339 | 64445860 |
Heart rate decreased | 15.76 | 13.96 | 13 | 52520 | 55054 | 64391145 |
Pallor | 15.63 | 13.96 | 6 | 52527 | 38775 | 64407424 |
Wheezing | 15.57 | 13.96 | 26 | 52507 | 80553 | 64365646 |
Loss of consciousness | 15.57 | 13.96 | 65 | 52468 | 148300 | 64297899 |
Aspartate aminotransferase | 15.46 | 13.96 | 6 | 52527 | 206 | 64445993 |
Cytomegalovirus test positive | 15.45 | 13.96 | 20 | 52513 | 5124 | 64441075 |
Alanine aminotransferase increased | 15.34 | 13.96 | 177 | 52356 | 138854 | 64307345 |
Drug intolerance | 15.33 | 13.96 | 90 | 52443 | 187902 | 64258297 |
Chronic granulomatous disease | 15.27 | 13.96 | 4 | 52529 | 36 | 64446163 |
Chills | 15.12 | 13.96 | 59 | 52474 | 137205 | 64308994 |
Fibrinous bronchitis | 15.08 | 13.96 | 4 | 52529 | 38 | 64446161 |
Throat irritation | 15.06 | 13.96 | 4 | 52529 | 32707 | 64413492 |
Apraxia | 15.05 | 13.96 | 14 | 52519 | 2481 | 64443718 |
Pythium insidiosum infection | 15.05 | 13.96 | 3 | 52530 | 6 | 64446193 |
Penicillium infection | 15.04 | 13.96 | 6 | 52527 | 222 | 64445977 |
Diabetic ketoacidosis | 15.04 | 13.96 | 3 | 52530 | 29842 | 64416357 |
Respiratory distress | 14.95 | 13.96 | 83 | 52450 | 52248 | 64393951 |
Ephelides | 14.94 | 13.96 | 5 | 52528 | 111 | 64446088 |
Sleep disorder | 14.86 | 13.96 | 16 | 52517 | 59693 | 64386506 |
Swollen tongue | 14.78 | 13.96 | 5 | 52528 | 34949 | 64411250 |
Oliguria | 14.72 | 13.96 | 35 | 52498 | 14541 | 64431658 |
Encephalitis | 14.71 | 13.96 | 32 | 52501 | 12539 | 64433660 |
Fungal abscess central nervous system | 14.69 | 13.96 | 5 | 52528 | 117 | 64446082 |
Neurological decompensation | 14.52 | 13.96 | 18 | 52515 | 4418 | 64441781 |
C-reactive protein abnormal | 14.47 | 13.96 | 3 | 52530 | 29044 | 64417155 |
Hepatomegaly | 14.38 | 13.96 | 38 | 52495 | 16844 | 64429355 |
Gastric perforation | 14.37 | 13.96 | 16 | 52517 | 3507 | 64442692 |
Incorrect dose administered | 14.34 | 13.96 | 17 | 52516 | 60748 | 64385451 |
Somnolence | 14.31 | 13.96 | 102 | 52431 | 203543 | 64242656 |
Respirovirus test positive | 14.27 | 13.96 | 5 | 52528 | 128 | 64446071 |
Pseudoaldosteronism | 14.16 | 13.96 | 5 | 52528 | 131 | 64446068 |
None
Source | Code | Description |
---|---|---|
ATC | J02AC03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOTICS FOR SYSTEMIC USE ANTIMYCOTICS FOR SYSTEMIC USE Triazole and tetrazole derivatives |
FDA CS | M0002083 | Azoles |
FDA EPC | N0000175487 | Azole Antifungal |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
FDA MoA | N0000182140 | Cytochrome P450 2C19 Inhibitors |
FDA MoA | N0000182141 | Cytochrome P450 3A4 Inhibitors |
FDA MoA | N0000185504 | Cytochrome P450 2C9 Inhibitors |
MeSH PA | D058888 | 14-alpha Demethylase Inhibitors |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000935 | Antifungal Agents |
MeSH PA | D065692 | Cytochrome P-450 CYP3A Inhibitors |
MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D006727 | Hormone Antagonists |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D065088 | Steroid Synthesis Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Invasive pulmonary aspergillosis | indication | 3214003 | |
Candidiasis of the esophagus | indication | 20639004 | DOID:13146 |
Fusarium infection | indication | 64250002 | |
Disseminated candidiasis | indication | 70572005 | |
Candidemia | indication | 432261003 | |
Fungal Infection due to Scedosporium Apiospermum | indication | ||
Fungal Infection due to Fusarium Solani | indication | ||
Oropharyngeal Candidiasis | off-label use | ||
Hypocalcemia | contraindication | 5291005 | |
Torsades de pointes | contraindication | 31722008 | |
Hypokalemia | contraindication | 43339004 | |
Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
Prolonged QT interval | contraindication | 111975006 | |
Hypomagnesemia | contraindication | 190855004 | |
Impaired renal function disorder | contraindication | 197663003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Visual impairment | contraindication | 397540003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Poor metabolizer due to cytochrome p450 CYP2C19 variant | contraindication | 424500005 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.93 | acidic |
pKa2 | 2.85 | Basic |
pKa3 | 1.42 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
200MG | VFEND | PF PRISM CV | N021266 | May 24, 2002 | RX | TABLET | ORAL | Jan. 29, 2022 | NEW PATIENT POPULATION |
50MG | VFEND | PF PRISM CV | N021266 | May 24, 2002 | RX | TABLET | ORAL | Jan. 29, 2022 | NEW PATIENT POPULATION |
200MG/VIAL | VFEND | PF PRISM CV | N021267 | May 24, 2002 | RX | INJECTABLE | INTRAVENOUS | Jan. 29, 2022 | NEW PATIENT POPULATION |
200MG/5ML | VFEND | PF PRISM CV | N021630 | Dec. 19, 2003 | RX | FOR SUSPENSION | ORAL | Jan. 29, 2022 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 2C9 | Enzyme | IC50 | 4.85 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 4.82 | CHEMBL | |||||
Cholesterol 24-hydroxylase | Enzyme | Ki | 7.96 | CHEMBL | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 4.89 | CHEMBL | |||||
Lanosterol 14-alpha demethylase | Enzyme | INHIBITOR | MIC | 8.73 | WOMBAT-PK | CHEMBL | |||
Lanosterol 14-alpha demethylase | Enzyme | MIC | 5.84 | WOMBAT-PK | |||||
14-alpha sterol demethylase Cyp51A | Enzyme | Kd | 5.44 | CHEMBL | |||||
14-alpha sterol demethylase | Enzyme | Kd | 6.37 | CHEMBL | |||||
Cytochrome P450 11A1 | Enzyme | Kd | 5.32 | CHEMBL | |||||
Sterol 14-alpha-demethylase | Enzyme | Kd | 7.25 | CHEMBL | |||||
14-alpha sterol demethylase | Enzyme | Kd | 7.25 | CHEMBL | |||||
14-alpha sterol demethylase | Enzyme | Kd | 7.25 | CHEMBL |
ID | Source |
---|---|
4021347 | VUID |
N0000148767 | NUI |
D00578 | KEGG_DRUG |
4021347 | VANDF |
C0393080 | UMLSCUI |
CHEBI:10023 | CHEBI |
VOR | PDB_CHEM_ID |
CHEMBL638 | ChEMBL_ID |
DB00582 | DRUGBANK_ID |
D065819 | MESH_DESCRIPTOR_UI |
71616 | PUBCHEM_CID |
7269 | INN_ID |
JFU09I87TR | UNII |
121243 | RXNORM |
16711 | MMSL |
179944 | MMSL |
43734 | MMSL |
d04803 | MMSL |
009650 | NDDF |
385469007 | SNOMEDCT_US |
386116008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3160 | POWDER, FOR SUSPENSION | 40 mg | ORAL | NDA | 34 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3160 | POWDER, FOR SUSPENSION | 40 mg | ORAL | NDA | 34 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3170 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 34 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3170 | TABLET, FILM COATED | 50 mg | ORAL | NDA | 34 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3180 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 34 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3180 | TABLET, FILM COATED | 200 mg | ORAL | NDA | 34 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-3190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-4190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
VFEND | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-4190 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | NDA | 33 sections |
Voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1626 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1626 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 31 sections |
Voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1640 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 31 sections |
Voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1640 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 31 sections |
Voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3416 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 10 mg | INTRAVENOUS | ANDA | 30 sections |
voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5667 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 30 sections |
voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5668 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 30 sections |
voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6471 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 30 sections |
voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6596 | TABLET | 50 mg | ORAL | ANDA | 28 sections |
Voriconazole | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7024 | TABLET | 200 mg | ORAL | ANDA | 27 sections |
Voriconazole | Human Prescription Drug Label | 1 | 16714-198 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Voriconazole | Human Prescription Drug Label | 1 | 16714-198 | TABLET, FILM COATED | 50 mg | ORAL | ANDA | 28 sections |
Voriconazole | Human Prescription Drug Label | 1 | 16714-199 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 28 sections |
Voriconazole | Human Prescription Drug Label | 1 | 16714-199 | TABLET, FILM COATED | 200 mg | ORAL | ANDA | 28 sections |
Voriconazole | Human Prescription Drug Label | 1 | 27241-062 | TABLET | 50 mg | ORAL | ANDA | 27 sections |
Voriconazole | Human Prescription Drug Label | 1 | 27241-063 | TABLET | 200 mg | ORAL | ANDA | 27 sections |