All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

voriconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	2846	137234-62-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: voriconazole voriconazol vfend UK109496 UK-109496 UK 109496	A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A. Molecular weight: 349.32 Formula: C16H14F3N5O CLOGP: 0.79 LIPINSKI: 0 HAC: 6 HDO: 1 TPSA: 76.72 ALOGS: -3.55 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	g	O
0.40	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.70 mg/mL	Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine)	1.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	34.35 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	96 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	2.20 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	8.30 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.42 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.60 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2B,AXL,EIF2AK3,GRK2,PDK1,PDK2,PDK4	7
kinase-selectivity-class	GRK2	1
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	3.041		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	0		High	1
rat-kpuu-brain	Rat brain Kpuu	0.358	%	High	1

Approvals:

Date	Agency	Company	Orphan
May 24, 2002	FDA	PF PRISM CV
March 19, 2002	EMA
April 11, 2005	PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	741.40	17.44	682	31613	275771	90320381
Mucormycosis	542.91	17.44	147	32148	3674	90592478
Bronchopulmonary aspergillosis	510.79	17.44	181	32114	11217	90584935
Periostitis	507.28	17.44	95	32200	377	90595775
Aspergillus infection	466.56	17.44	167	32128	10656	90585496
Multiple organ dysfunction syndrome	439.01	17.44	284	32011	68052	90528100
Drug ineffective	435.81	17.44	1272	31023	1383026	89213126
Drug resistance	314.54	17.44	172	32123	30277	90565875
Photosensitivity reaction	312.22	17.44	144	32151	17663	90578489
Respiratory failure	300.58	17.44	284	32011	118134	90478018
Drug level increased	287.25	17.44	157	32138	27605	90568547
Hallucination, visual	273.81	17.44	143	32152	22949	90573203
Pneumonia fungal	260.30	17.44	97	32198	6934	90589218
Septic shock	244.97	17.44	218	32077	83942	90512210
Cholestasis	240.70	17.44	154	32141	36145	90560007
Drug level below therapeutic	221.79	17.44	82	32213	5732	90590420
Febrile neutropenia	217.72	17.44	275	32020	158074	90438078
Drug level decreased	193.72	17.44	86	32209	9644	90586508
Acute myeloid leukaemia	176.35	17.44	103	32192	20537	90575615
Squamous cell carcinoma of skin	174.99	17.44	74	32221	7375	90588777
Systemic mycosis	163.05	17.44	47	32248	1483	90594669
Hallucination	163.03	17.44	156	32139	65803	90530349
Fungal infection	162.25	17.44	129	32166	42532	90553620
Graft versus host disease	162.19	17.44	72	32223	8072	90588080
Actinic keratosis	155.70	17.44	54	32241	3134	90593018
Pain	152.57	17.44	83	32212	996258	89599894
Hepatotoxicity	149.98	17.44	127	32168	45715	90550437
Pathogen resistance	143.39	17.44	66	32229	8049	90588103
Cerebral aspergillosis	140.02	17.44	34	32261	541	90595611
Fatigue	136.27	17.44	127	32168	1153896	89442256
Joint swelling	132.66	17.44	13	32282	503287	90092865
Pancytopenia	128.74	17.44	185	32110	120078	90476074
Fusarium infection	123.20	17.44	35	32260	1047	90595105
Sepsis	120.83	17.44	224	32071	179590	90416562
Photodermatosis	118.79	17.44	30	32265	565	90595587
Pulmonary mucormycosis	118.54	17.44	30	32265	570	90595582
Arthropathy	116.44	17.44	3	32292	366239	90229913
Dilatation intrahepatic duct acquired	115.91	17.44	31	32264	737	90595415
Hepatic cytolysis	114.38	17.44	92	32203	30824	90565328
Neurotoxicity	113.18	17.44	79	32216	21388	90574764
Fluorosis	109.64	17.44	22	32273	134	90596018
Rheumatoid arthritis	105.03	17.44	6	32289	362608	90233544
Hepatic function abnormal	98.63	17.44	101	32194	46187	90549965
Swelling	97.87	17.44	16	32279	419042	90177110
Venoocclusive liver disease	97.38	17.44	46	32249	5947	90590205
Fluoride increased	97.06	17.44	15	32280	9	90596143
Abdominal discomfort	95.58	17.44	26	32269	477302	90118850
Cytomegalovirus infection	91.75	17.44	76	32219	26526	90569626
Renal impairment	91.31	17.44	147	32148	105274	90490878
Acute respiratory distress syndrome	90.80	17.44	78	32217	28608	90567544
Gamma-glutamyltransferase increased	88.55	17.44	87	32208	37865	90558287
Synovitis	88.20	17.44	8	32287	329744	90266408
Enterococcal infection	85.70	17.44	50	32245	9941	90586211
Therapeutic product effect decreased	85.57	17.44	3	32292	277568	90318584
Wound	84.79	17.44	6	32289	302974	90293178
Fungaemia	84.45	17.44	35	32260	3315	90592837
Nasopharyngitis	83.72	17.44	21	32274	407083	90189069
Peripheral swelling	83.63	17.44	22	32273	413084	90183068
Brain abscess	83.34	17.44	33	32262	2779	90593373
Skin candida	83.13	17.44	29	32266	1712	90594440
Pruritus	82.80	17.44	45	32250	541480	90054672
Musculoskeletal stiffness	82.61	17.44	6	32289	296526	90299626
Drug ineffective for unapproved indication	82.49	17.44	110	32185	66534	90529618
Scedosporium infection	81.93	17.44	24	32271	802	90595350
Disorganised speech	80.88	17.44	29	32266	1856	90594296
Blood bilirubin increased	78.71	17.44	87	32208	43383	90552769
Infusion related reaction	77.44	17.44	26	32269	416754	90179398
Encephalopathy	77.35	17.44	89	32206	46355	90549797
Acute graft versus host disease	76.85	17.44	38	32257	5430	90590722
Pyrexia	76.43	17.44	448	31847	660037	89936115
Neutropenia	75.62	17.44	213	32082	224691	90371461
Toxoplasmosis	74.85	17.44	27	32268	1758	90594394
Pseudomonas infection	74.40	17.44	53	32242	14812	90581340
Electrocardiogram QT prolonged	73.91	17.44	109	32186	72347	90523805
Systemic lupus erythematosus	71.87	17.44	20	32275	361876	90234276
Arthralgia	71.85	17.44	104	32191	778418	89817734
Immunosuppressant drug level increased	70.19	17.44	34	32261	4646	90591506
Candida infection	70.18	17.44	73	32222	33984	90562168
Disseminated aspergillosis	70.13	17.44	19	32276	475	90595677
Visual impairment	69.71	17.44	149	32146	132216	90463936
Posterior reversible encephalopathy syndrome	69.19	17.44	60	32235	22279	90573873
Polyserositis	68.72	17.44	20	32275	653	90595499
Hypertrophic osteoarthropathy	68.55	17.44	12	32283	29	90596123
Fungal test positive	67.87	17.44	19	32276	538	90595614
Pulmonary alveolar haemorrhage	67.82	17.44	36	32259	5962	90590190
Impaired healing	67.40	17.44	4	32291	234195	90361957
Blood alkaline phosphatase increased	66.75	17.44	84	32211	47995	90548157
Graft versus host disease in gastrointestinal tract	66.18	17.44	32	32263	4356	90591796
Drug hypersensitivity	65.92	17.44	42	32253	463567	90132585
Death	65.10	17.44	328	31967	456223	90139929
Hypersensitivity	64.91	17.44	41	32254	454636	90141516
Mobility decreased	64.63	17.44	7	32288	250727	90345425
Torsade de pointes	64.41	17.44	49	32246	15133	90581019
Acute graft versus host disease in intestine	63.67	17.44	25	32270	2058	90594094
Alopecia	63.62	17.44	50	32245	495021	90101131
Alanine aminotransferase increased	63.22	17.44	134	32161	118204	90477948
Pneumonia bacterial	62.63	17.44	45	32250	12745	90583407
Cytomegalovirus viraemia	62.53	17.44	37	32258	7549	90588603
Solar lentigo	61.56	17.44	21	32274	1159	90594993
Pericarditis	61.52	17.44	11	32284	270140	90326012
Neutrophil count decreased	60.90	17.44	99	32196	71433	90524719
Acute kidney injury	60.40	17.44	250	32045	320137	90276015
Type 2 diabetes mellitus	59.95	17.44	3	32292	203241	90392911
Squamous cell carcinoma	59.94	17.44	40	32255	10061	90586091
Xanthopsia	58.80	17.44	14	32281	204	90595948
Injury	57.93	17.44	3	32292	197346	90398806
Osteoarthritis	57.38	17.44	3	32292	195727	90400425
Corneal perforation	57.25	17.44	17	32278	596	90595556
Geotrichum infection	57.17	17.44	17	32278	599	90595553
Acute myeloid leukaemia recurrent	57.00	17.44	23	32272	2034	90594118
Aspartate aminotransferase increased	56.66	17.44	118	32177	102819	90493333
Thrombotic microangiopathy	56.42	17.44	46	32249	15697	90580455
Gliosis	56.30	17.44	16	32279	479	90595673
Pain in extremity	56.01	17.44	47	32248	450482	90145670
Blood cholesterol increased	55.72	17.44	5	32290	208007	90388145
Pouchitis	55.58	17.44	17	32278	660	90595492
Headache	55.40	17.44	143	32152	862603	89733549
Nervous system disorder	55.08	17.44	52	32243	21541	90574611
Acute graft versus host disease in skin	55.06	17.44	29	32266	4727	90591425
Brain oedema	54.46	17.44	47	32248	17338	90578814
Platelet count decreased	54.36	17.44	138	32157	136831	90459321
Rash	54.20	17.44	128	32167	795972	89800180
Urticaria	53.87	17.44	22	32273	312712	90283440
Bronchial anastomosis complication	53.75	17.44	11	32284	75	90596077
Haemophagocytic lymphohistiocytosis	52.96	17.44	44	32251	15415	90580737
Acute graft versus host disease in liver	52.66	17.44	17	32278	789	90595363
Staphylococcal infection	52.49	17.44	75	32220	48364	90547788
Hypokalaemia	51.93	17.44	132	32163	130984	90465168
Fungal endocarditis	51.56	17.44	14	32281	353	90595799
Malaise	51.36	17.44	81	32214	585905	90010247
Off label use	51.16	17.44	608	31687	1101644	89494508
Pleural effusion	49.93	17.44	118	32177	111873	90484279
Fall	49.87	17.44	59	32236	481751	90114401
Drug level above therapeutic	49.63	17.44	29	32266	5780	90590372
Mucosal inflammation	49.38	17.44	80	32215	57545	90538607
Shock	49.35	17.44	56	32239	28722	90567430
Bone marrow failure	49.09	17.44	59	32236	32162	90563990
Graft versus host disease in skin	48.93	17.44	25	32270	3828	90592324
Systemic candida	48.39	17.44	27	32268	4932	90591220
Intracranial infection	47.97	17.44	12	32283	217	90595935
Weight increased	47.88	17.44	47	32248	417880	90178272
Fibromyalgia	47.83	17.44	8	32287	206261	90389891
Product use in unapproved indication	47.47	17.44	241	32054	335995	90260157
Migraine	47.35	17.44	6	32289	190386	90405766
Pneumonia	46.59	17.44	387	31908	637672	89958480
Necrosis	46.17	17.44	29	32266	6581	90589571
Haemoptysis	45.90	17.44	58	32237	33262	90562890
Exposure during pregnancy	45.79	17.44	14	32281	238396	90357756
Aspergilloma	45.20	17.44	12	32283	277	90595875
Cardiac tamponade	45.20	17.44	27	32268	5605	90590547
Tracheobronchitis	44.88	17.44	18	32277	1567	90594585
Product dose omission issue	44.86	17.44	24	32271	291663	90304489
Strongyloidiasis	44.69	17.44	18	32277	1584	90594568
Chronic graft versus host disease	44.43	17.44	24	32271	4115	90592037
Endophthalmitis	44.34	17.44	25	32270	4660	90591492
Ovarian failure	44.25	17.44	18	32277	1625	90594527
Dizziness	43.96	17.44	90	32205	589194	90006958
Cytokine release syndrome	43.89	17.44	52	32243	27921	90568231
Lentigo	43.70	17.44	14	32281	634	90595518
Altered state of consciousness	43.62	17.44	55	32240	31477	90564675
Disseminated mucormycosis	43.22	17.44	14	32281	657	90595495
Maternal exposure during pregnancy	42.99	17.44	39	32256	360024	90236128
Stenotrophomonas infection	42.90	17.44	20	32275	2509	90593643
Disease progression	42.85	17.44	138	32157	156477	90439675
Liver function test abnormal	42.77	17.44	70	32225	50775	90545377
Contusion	42.73	17.44	18	32277	251198	90344954
Hepatocellular injury	42.44	17.44	52	32243	28906	90567246
Mixed liver injury	42.40	17.44	29	32266	7594	90588558
Chromatopsia	42.40	17.44	13	32282	509	90595643
Sinusitis	42.36	17.44	36	32259	343052	90253100
Abdominal pain upper	42.19	17.44	34	32261	332640	90263512
Drug intolerance	41.98	17.44	59	32236	447532	90148620
Acute lymphocytic leukaemia recurrent	41.51	17.44	20	32275	2701	90593451
Pulmonary haemorrhage	41.09	17.44	29	32266	7984	90588168
Cerebral fungal infection	40.87	17.44	11	32284	268	90595884
Lung transplant rejection	40.87	17.44	15	32280	1026	90595126
Bacterial infection	40.85	17.44	46	32249	23398	90572754
Premature menopause	40.80	17.44	16	32279	1313	90594839
Infective aneurysm	40.27	17.44	12	32283	426	90595726
Immune recovery uveitis	39.97	17.44	8	32287	48	90596104
Renal failure	39.12	17.44	119	32176	130888	90465264
Immunosuppression	38.54	17.44	33	32262	12044	90584108
Psoriasis	38.38	17.44	4	32291	147750	90448402
Chloropsia	38.08	17.44	8	32287	63	90596089
Dyschromatopsia	37.65	17.44	13	32282	744	90595408
Trichosporon infection	37.48	17.44	11	32284	370	90595782
Wheezing	37.48	17.44	19	32276	238061	90358091
Gastrooesophageal reflux disease	37.36	17.44	7	32288	166330	90429822
Disseminated intravascular coagulation	37.08	17.44	42	32253	21496	90574656
Ill-defined disorder	37.08	17.44	10	32285	184881	90411271
Hypomagnesaemia	36.95	17.44	54	32241	35534	90560618
Dry mouth	36.83	17.44	10	32285	184049	90412103
Aspergillus test positive	36.68	17.44	11	32284	399	90595753
Dehiscence	36.39	17.44	9	32286	155	90595997
Fungal skin infection	36.38	17.44	23	32272	5278	90590874
Hypoxia	36.38	17.44	80	32215	72319	90523833
Myoclonus	35.79	17.44	39	32256	19129	90577023
Halo vision	35.75	17.44	11	32284	436	90595716
Tonsillitis bacterial	35.66	17.44	9	32286	169	90595983
Gastrointestinal disorder	35.43	17.44	24	32271	256663	90339489
Toxic encephalopathy	34.55	17.44	27	32268	8672	90587480
Proctectomy	34.23	17.44	9	32286	200	90595952
Pneumothorax	34.06	17.44	38	32257	19129	90577023
Neurological decompensation	33.99	17.44	19	32276	3482	90592670
Nephropathy toxic	33.21	17.44	31	32264	12657	90583495
Chest pain	33.19	17.44	39	32256	319606	90276546
Leukoencephalopathy	33.09	17.44	21	32274	4852	90591300
Anxiety	33.03	17.44	37	32258	309735	90286417
Pericarditis fungal	32.59	17.44	7	32288	62	90596090
Thrombocytopenia	32.56	17.44	154	32141	208571	90387581
Leukaemia recurrent	32.55	17.44	14	32281	1453	90594699
Lower respiratory tract infection	32.55	17.44	25	32270	250634	90345518
Antiphospholipid syndrome	32.54	17.44	16	32279	2258	90593894
Dyspepsia	32.42	17.44	15	32280	198145	90398007
Cortical visual impairment	32.41	17.44	6	32289	22	90596130
Pseudoaldosteronism	32.23	17.44	8	32287	140	90596012
Acute lymphocytic leukaemia	31.93	17.44	17	32278	2831	90593321
Coccidioidomycosis	31.89	17.44	13	32282	1180	90594972
Human herpesvirus 6 infection	31.63	17.44	18	32277	3414	90592738
Rash maculo-papular	31.29	17.44	54	32241	40879	90555273
Granulomatous liver disease	31.17	17.44	12	32283	937	90595215
Graft versus host disease in liver	31.00	17.44	12	32283	951	90595201
Bursitis	30.75	17.44	5	32290	131649	90464503
Dysbiosis	30.56	17.44	14	32281	1688	90594464
Mental status changes	30.38	17.44	56	32239	44623	90551529
Photopsia	30.06	17.44	20	32275	5004	90591148
Imprisonment	29.84	17.44	9	32286	333	90595819
Upper airway necrosis	29.57	17.44	6	32289	39	90596113
Apallic syndrome	29.52	17.44	11	32284	785	90595367
Sleep disorder	29.42	17.44	17	32278	198013	90398139
Rhinocerebral mucormycosis	29.31	17.44	11	32284	801	90595351
Photophobia	29.26	17.44	37	32258	21232	90574920
Hypertransaminasaemia	29.20	17.44	32	32263	15793	90580359
Adenovirus infection	29.12	17.44	19	32276	4603	90591549
Vision blurred	29.09	17.44	96	32199	110197	90485955
Venous thrombosis limb	28.83	17.44	17	32278	3445	90592707
Infection reactivation	28.81	17.44	14	32281	1926	90594226
Fungal sepsis	28.69	17.44	13	32282	1528	90594624
Immunosuppressant drug level decreased	28.68	17.44	12	32283	1164	90594988
Infective pulmonary exacerbation of cystic fibrosis	28.63	17.44	26	32269	10253	90585899
Hyperlactacidaemia	28.52	17.44	18	32277	4118	90592034
Cerebral haemorrhage	28.32	17.44	47	32248	34475	90561677
Cytopenia	28.31	17.44	33	32262	17416	90578736
Dermatitis exfoliative	28.30	17.44	20	32275	5516	90590636
Peritonitis	28.26	17.44	35	32260	19670	90576482
Infection in an immunocompromised host	28.14	17.44	11	32284	895	90595257
Muscle spasms	28.05	17.44	29	32266	251854	90344298
Bacteraemia	27.87	17.44	37	32258	22263	90573889
Blood lactate dehydrogenase increased	27.87	17.44	40	32255	25892	90570260
Blister	27.68	17.44	30	32265	254968	90341184
Gait inability	27.40	17.44	9	32286	146447	90449705
Neck pain	27.36	17.44	4	32291	113959	90482193
Lower respiratory tract infection fungal	27.35	17.44	8	32287	266	90595886
Necrotising colitis	27.19	17.44	12	32283	1326	90594826
Stomatitis	26.95	17.44	35	32260	274663	90321489
Hypoaesthesia	26.94	17.44	44	32251	314166	90281986
Drug-induced liver injury	26.91	17.44	82	32213	90236	90505916
Dermatitis bullous	26.61	17.44	25	32270	10291	90585861
Somatic symptom disorder	26.33	17.44	16	32279	3425	90592727
Septal panniculitis	26.05	17.44	6	32289	75	90596077
Primary myelofibrosis	26.05	17.44	6	32289	75	90596077
Respirovirus test positive	25.92	17.44	5	32290	24	90596128
Hallucination, auditory	25.56	17.44	30	32265	15945	90580207
Colour blindness	25.55	17.44	8	32287	336	90595816
Acinetobacter infection	25.41	17.44	13	32282	1995	90594157
Procalcitonin increased	25.39	17.44	12	32283	1552	90594600
Pneumomediastinum	25.27	17.44	13	32282	2018	90594134
Mycotic endophthalmitis	25.25	17.44	7	32288	191	90595961
Aspergillus test	25.13	17.44	5	32290	29	90596123
Functional residual capacity increased	24.85	17.44	6	32289	93	90596059
Anal infection	24.85	17.44	6	32289	93	90596059
Pseudomonas test positive	24.55	17.44	10	32285	906	90595246
Cachexia	24.44	17.44	20	32275	6858	90589294
Adverse drug reaction	23.99	17.44	6	32289	116695	90479457
Feeling abnormal	23.93	17.44	15	32280	167220	90428932
Insomnia	23.93	17.44	52	32243	333422	90262730
Traumatic haemothorax	23.61	17.44	7	32288	244	90595908
Depressed level of consciousness	23.51	17.44	68	32227	72716	90523436
Paraesthesia	23.44	17.44	33	32262	250293	90345859
Lung infiltration	23.30	17.44	28	32267	15254	90580898
Bacterial sepsis	23.27	17.44	17	32278	4938	90591214
Lip dry	23.21	17.44	4	32291	100951	90495201
Leukaemia	23.16	17.44	17	32278	4975	90591177
Diarrhoea	23.01	17.44	219	32076	938971	89657181
Mycobacterium abscessus infection	23.01	17.44	10	32285	1065	90595087
Venoocclusive disease	22.96	17.44	13	32282	2442	90593710
Phaeohyphomycosis	22.89	17.44	8	32287	475	90595677
Weight decreased	22.77	17.44	65	32230	379845	90216307
Blood pressure increased	22.76	17.44	22	32273	197195	90398957
Agranulocytosis	22.71	17.44	43	32252	34959	90561193
Skin cancer	22.66	17.44	26	32269	13493	90582659
Fungal disease carrier	22.55	17.44	5	32290	52	90596100
Toxic epidermal necrolysis	22.40	17.44	41	32254	32487	90563665
Adverse event	22.34	17.44	7	32288	117411	90478741
Hypophosphataemia	22.30	17.44	27	32268	14827	90581325
Ileostomy closure	22.29	17.44	7	32288	297	90595855
Central nervous system fungal infection	22.26	17.44	6	32289	147	90596005
Cytomegalovirus infection reactivation	22.25	17.44	20	32275	7780	90588372
Cardiac arrest	22.23	17.44	85	32210	104850	90491302
Chronic papillomatous dermatitis	22.21	17.44	5	32290	56	90596096
Post transplant lymphoproliferative disorder	22.20	17.44	19	32276	6930	90589222
Hepatic enzyme increased	22.15	17.44	61	32234	360675	90235477
Scintillating scotoma	22.15	17.44	6	32289	150	90596002
Gastrointestinal polyp	22.03	17.44	6	32289	153	90595999
Eye abscess	21.92	17.44	6	32289	156	90595996
Obliterative bronchiolitis	21.90	17.44	13	32282	2668	90593484
Graft versus host disease in lung	21.87	17.44	8	32287	542	90595610
Osteoporosis	21.81	17.44	4	32291	96527	90499625
Blood beta-D-glucan increased	21.77	17.44	7	32288	321	90595831
Asthma	21.62	17.44	33	32262	242127	90354025
Capillary leak syndrome	21.52	17.44	13	32282	2754	90593398
Hypertension	21.49	17.44	87	32208	457445	90138707
Klebsiella infection	21.08	17.44	22	32273	10275	90585877
Cholecystitis acute	20.90	17.44	21	32274	9383	90586769
Ocular surface squamous neoplasia	20.82	17.44	3	32292	0	90596152
Erythropsia	20.82	17.44	3	32292	0	90596152
Cytomegalovirus test positive	20.78	17.44	14	32281	3577	90592575
Inappropriate schedule of product administration	20.70	17.44	14	32281	149919	90446233
Respiratory distress	20.66	17.44	44	32251	38902	90557250
Hepatic artery aneurysm	20.60	17.44	4	32291	20	90596132
Septic embolus	20.45	17.44	9	32286	988	90595164
Keratitis fungal	20.41	17.44	6	32289	203	90595949
Tuberculosis gastrointestinal	20.30	17.44	7	32288	399	90595753
Delirium	20.06	17.44	82	32213	104277	90491875
Back pain	19.94	17.44	53	32242	317122	90279030
Palpitations	19.93	17.44	12	32283	136716	90459436
Intentional product use issue	19.90	17.44	29	32266	216863	90379289
Musculoskeletal pain	19.88	17.44	19	32276	171232	90424920
Hepatic candidiasis	19.85	17.44	4	32291	25	90596127
Torticollis	19.84	17.44	12	32283	2546	90593606
Nocardiosis	19.79	17.44	12	32283	2558	90593594
Loss of personal independence in daily activities	19.76	17.44	12	32283	136093	90460059
Amnesia	19.72	17.44	7	32288	108498	90487654
Tumour lysis syndrome	19.63	17.44	22	32273	11130	90585022
Drug abuse	19.51	17.44	3	32292	82344	90513808
Myoglobin blood increased	19.50	17.44	10	32285	1542	90594610
Memory impairment	19.48	17.44	25	32270	197219	90398933
Pulmonary fibrosis	19.43	17.44	7	32288	107496	90488656
Wound infection	19.10	17.44	7	32288	106395	90489757
Upper respiratory tract infection	19.07	17.44	11	32284	128307	90467845
Stem cell transplant	19.06	17.44	11	32284	2143	90594009
Neutropenic colitis	18.97	17.44	14	32281	4129	90592023
Mental disorder	18.89	17.44	38	32257	32280	90563872
Brain herniation	18.80	17.44	14	32281	4186	90591966
Cross sensitivity reaction	18.62	17.44	12	32283	2845	90593307
Babesiosis	18.58	17.44	6	32289	279	90595873
Chronic graft versus host disease in skin	18.57	17.44	9	32286	1231	90594921
Respiratory tract infection fungal	18.53	17.44	7	32288	519	90595633
Leukopenia	18.47	17.44	78	32217	100632	90495520
Cytomegalovirus enterocolitis	18.28	17.44	8	32287	866	90595286
Sputum increased	18.25	17.44	12	32283	2945	90593207
Central nervous system infection	18.22	17.44	8	32287	873	90595279
Aplastic anaemia	18.12	17.44	23	32272	13246	90582906
Laryngeal inflammation	18.05	17.44	5	32290	136	90596016
Renal aneurysm	18.01	17.44	4	32291	42	90596110
Encephalitis	17.97	17.44	21	32274	11113	90585039
Haemothorax	17.88	17.44	11	32284	2407	90593745
Cytomegalovirus chorioretinitis	17.87	17.44	11	32284	2408	90593744
Acute respiratory failure	17.80	17.44	44	32251	42874	90553278
Herpes simplex	17.77	17.44	20	32275	10161	90585991
Hepatosplenic candidiasis	17.68	17.44	6	32289	326	90595826
Hyperkalaemia	17.53	17.44	57	32238	64907	90531245
Osteomyelitis fungal	17.52	17.44	4	32291	48	90596104
Cystitis haemorrhagic	17.46	17.44	15	32280	5498	90590654
Red blood cell sedimentation rate increased	17.46	17.44	4	32291	82591	90513561

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	845.94	13.79	2058	46506	628139	41944632
Photosensitivity reaction	790.20	13.79	353	48211	12349	42560422
Drug interaction	746.87	13.79	1191	47373	265808	42306963
Bronchopulmonary aspergillosis	672.89	13.79	362	48202	19067	42553704
Aspergillus infection	659.78	13.79	334	48230	15503	42557268
Drug level increased	500.95	13.79	333	48231	25867	42546904
Periostitis	436.14	13.79	97	48467	254	42572517
Mucormycosis	417.05	13.79	190	48374	6953	42565818
Actinic keratosis	414.33	13.79	172	48392	5004	42567767
Hallucination, visual	391.73	13.79	263	48301	20757	42552014
Drug resistance	351.61	13.79	300	48264	33948	42538823
Cerebral aspergillosis	335.60	13.79	111	48453	1666	42571105
Squamous cell carcinoma of skin	334.44	13.79	198	48366	12528	42560243
Hallucination	297.76	13.79	347	48217	57160	42515611
Multiple organ dysfunction syndrome	265.64	13.79	430	48134	96605	42476166
Hepatotoxicity	265.52	13.79	224	48340	24943	42547828
Fungal infection	225.63	13.79	184	48380	19538	42553233
Pathogen resistance	203.08	13.79	139	48425	11311	42561460
Scedosporium infection	192.73	13.79	71	48493	1487	42571284
Pneumonia fungal	186.23	13.79	121	48443	9025	42563746
Fatigue	180.50	13.79	140	48424	435501	42137270
Septic shock	177.08	13.79	349	48215	91323	42481448
Photodermatosis	174.21	13.79	55	48509	705	42572066
Respiratory failure	158	13.79	408	48156	127724	42445047
Graft versus host disease	157.18	13.79	125	48439	12800	42559971
Squamous cell carcinoma	154.56	13.79	124	48440	12858	42559913
Systemic mycosis	153.65	13.79	68	48496	2319	42570452
Choroiditis	153.06	13.79	58	48506	1317	42571454
Disorganised speech	143.82	13.79	56	48508	1372	42571399
Hepatic function abnormal	133.46	13.79	223	48341	51344	42521427
Drug level below therapeutic	124.51	13.79	83	48481	6462	42566309
Product dose omission issue	119.43	13.79	17	48547	154348	42418423
Solar lentigo	117.30	13.79	39	48525	595	42572176
Fusarium infection	116.94	13.79	50	48514	1566	42571205
Drug ineffective for unapproved indication	115.95	13.79	197	48367	45966	42526805
Condition aggravated	114.14	13.79	592	47972	260162	42312609
Cholestasis	112.83	13.79	162	48402	32717	42540054
Visual impairment	110.96	13.79	186	48378	42927	42529844
Drug level decreased	109.72	13.79	91	48473	9886	42562885
Febrile neutropenia	107.89	13.79	458	48106	185245	42387526
Pain	105.89	13.79	75	48489	244773	42327998
Dysplastic naevus	102.57	13.79	36	48528	652	42572119
Drug abuse	101.93	13.79	4	48560	104767	42468004
Acute myeloid leukaemia	98.27	13.79	124	48440	22132	42550639
Completed suicide	96.23	13.79	3	48561	96462	42476309
Fall	94.79	13.79	77	48487	234443	42338328
Aspergilloma	92.27	13.79	30	48534	425	42572346
Fluoride increased	91.75	13.79	20	48544	46	42572725
Cheilitis	91.33	13.79	49	48515	2559	42570212
Immunosuppressant drug level increased	90.22	13.79	73	48491	7658	42565113
Nephropathy toxic	89.36	13.79	103	48461	16735	42556036
Candida infection	88.50	13.79	116	48448	21494	42551277
Fungaemia	88.17	13.79	51	48513	3085	42569686
Brain abscess	88.00	13.79	57	48507	4227	42568544
Disseminated mucormycosis	87.52	13.79	39	48525	1352	42571419
Pruritus	85.35	13.79	55	48509	188716	42384055
Neurotoxicity	80.35	13.79	116	48448	23535	42549236
Pulmonary mucormycosis	79.57	13.79	37	48527	1418	42571353
Asthenia	77.86	13.79	125	48439	280668	42292103
Treatment failure	77.66	13.79	200	48364	62424	42510347
Fluorosis	76.02	13.79	17	48547	46	42572725
Aspergillus test positive	75.98	13.79	29	48535	672	42572099
Drug level above therapeutic	75.85	13.79	59	48505	5847	42566924
Drug-induced liver injury	75.35	13.79	147	48417	38126	42534645
Pseudomonas infection	73.94	13.79	91	48473	15832	42556939
Arthralgia	73.82	13.79	75	48489	205163	42367608
Depression	71.93	13.79	19	48545	111344	42461427
Visual acuity reduced	71.54	13.79	94	48470	17456	42555315
Myocardial infarction	71.42	13.79	26	48538	123983	42448788
Dyspnoea	68.75	13.79	266	48298	442355	42130416
Fungal endocarditis	68.10	13.79	24	48540	440	42572331
Anxiety	68.04	13.79	25	48539	118535	42454236
Dyschromatopsia	67.83	13.79	25	48539	524	42572247
Intraocular pressure increased	67.27	13.79	57	48507	6376	42566395
Constipation	67.13	13.79	52	48512	162239	42410532
Lip squamous cell carcinoma	65.65	13.79	18	48546	135	42572636
Acute myeloid leukaemia recurrent	65.51	13.79	44	48520	3468	42569303
Off label use	65.44	13.79	1054	47510	637281	41935490
Graft versus host disease in gastrointestinal tract	65.23	13.79	51	48513	5092	42567679
Nausea	63.84	13.79	235	48329	396564	42176207
Pain in extremity	62.61	13.79	48	48516	150556	42422215
Delirium	62.31	13.79	165	48399	52354	42520417
Xanthopsia	59.87	13.79	17	48547	147	42572624
Blood pressure increased	57.63	13.79	22	48542	101906	42470865
Diarrhoea	56.57	13.79	302	48262	460547	42112224
Toxic optic neuropathy	55.49	13.79	26	48538	1014	42571757
Hepatocellular injury	55.44	13.79	98	48466	23580	42549191
Nasopharyngitis	54.87	13.79	14	48550	83982	42488789
Dizziness	54.25	13.79	128	48436	249126	42323645
Back pain	54.22	13.79	49	48515	141727	42431044
Inappropriate schedule of product administration	53.72	13.79	21	48543	95881	42476890
Hepatitis cholestatic	53.65	13.79	61	48503	9763	42563008
Mental disorder	53.48	13.79	83	48481	17946	42554825
Uveitis	53.14	13.79	59	48505	9199	42563572
Dehydration	53.03	13.79	50	48514	141717	42431054
Enterococcal infection	53.01	13.79	67	48497	11972	42560799
Acute graft versus host disease in skin	52.74	13.79	53	48511	7371	42565400
Chloropsia	52.49	13.79	10	48554	7	42572764
Mediastinitis	52.31	13.79	25	48539	1020	42571751
Phaeohyphomycosis	52.28	13.79	26	48538	1158	42571613
Disseminated intravascular coagulation	52.20	13.79	98	48466	24696	42548075
Hypertension	51.59	13.79	69	48495	167135	42405636
Disseminated aspergillosis	50.95	13.79	29	48535	1701	42571070
Blood alkaline phosphatase increased	50.94	13.79	116	48448	33481	42539290
Pancytopenia	50.41	13.79	266	48298	117477	42455294
Malaise	48.54	13.79	106	48458	212050	42360721
Injection site pain	48.01	13.79	5	48559	57793	42514978
Eye pain	47.20	13.79	76	48488	16954	42555817
Weight decreased	46.67	13.79	105	48459	207843	42364928
Headache	45.89	13.79	131	48433	239238	42333533
Alternaria infection	44.62	13.79	19	48545	589	42572182
Peripheral swelling	43.99	13.79	24	48540	90246	42482525
Intentional overdose	43.92	13.79	4	48560	51452	42521319
Leukaemia recurrent	43.62	13.79	27	48537	1849	42570922
Asthma	43.45	13.79	9	48555	62305	42510466
Sinusitis fungal	43.39	13.79	20	48544	751	42572020
Osteomyelitis fungal	43.34	13.79	16	48548	337	42572434
Cytomegalovirus viraemia	42.94	13.79	56	48508	10321	42562450
Cardiac failure congestive	42.83	13.79	22	48542	85580	42487191
Hyperhidrosis	42.77	13.79	25	48539	90487	42482284
Endophthalmitis	41.74	13.79	37	48527	4396	42568375
Product compounding quality issue	41.50	13.79	9	48555	20	42572751
Enterococcal sepsis	41.50	13.79	27	48537	2017	42570754
Renal abscess	41.39	13.79	16	48548	384	42572387
Musculoskeletal stiffness	40.99	13.79	8	48556	57757	42515014
Cytomegalovirus infection	40.87	13.79	104	48460	32202	42540569
Inappropriate antidiuretic hormone secretion	40.72	13.79	70	48494	16471	42556300
Chest pain	40.62	13.79	60	48504	139470	42433301
Urticaria	40.17	13.79	17	48547	74019	42498752
Abscess fungal	40.06	13.79	15	48549	329	42572442
Septic embolus	39.90	13.79	23	48541	1382	42571389
Loss of personal independence in daily activities	39.64	13.79	5	48559	49811	42522960
Prostate cancer	39.40	13.79	3	48561	44640	42528131
Acute respiratory distress syndrome	39.21	13.79	98	48466	30010	42542761
Photophobia	38.66	13.79	47	48517	8072	42564699
Gamma-glutamyltransferase increased	38.43	13.79	102	48462	32395	42540376
Dysphoria	38.39	13.79	29	48535	2751	42570020
Pulmonary embolism	38.28	13.79	48	48516	119564	42453207
Acute graft versus host disease	38.22	13.79	47	48517	8168	42564603
Pseudoporphyria	38.12	13.79	16	48548	478	42572293
Muscle spasms	37.59	13.79	26	48538	86018	42486753
Cystitis haemorrhagic	37.48	13.79	44	48520	7285	42565486
Rectal haemorrhage	37.09	13.79	6	48558	49600	42523171
Stenotrophomonas infection	37.05	13.79	32	48532	3672	42569099
Foetal exposure during pregnancy	37.04	13.79	5	48559	47306	42525465
Gallbladder oedema	36.86	13.79	13	48551	239	42572532
Human polyomavirus infection	36.12	13.79	21	48543	1282	42571489
Hepatic cytolysis	35.62	13.79	88	48476	26756	42546015
Intentional product misuse	35.58	13.79	13	48551	61887	42510884
Dyspnoea exertional	35.47	13.79	7	48557	50141	42522630
Photopsia	35.37	13.79	26	48538	2366	42570405
Halo vision	35.33	13.79	12	48552	196	42572575
Acute graft versus host disease in intestine	35.27	13.79	32	48532	3919	42568852
Graft versus host disease in skin	34.82	13.79	36	48528	5176	42567595
Joint swelling	34.75	13.79	17	48547	68005	42504766
Mycobacterium avium complex infection	34.09	13.79	28	48536	2999	42569772
Product use issue	33.93	13.79	175	48389	76576	42496195
Psoriasis	33.93	13.79	7	48557	48597	42524174
Pneumonia necrotising	33.88	13.79	19	48545	1083	42571688
Central nervous system lesion	33.39	13.79	43	48521	7827	42564944
Blood bilirubin increased	33.33	13.79	115	48449	42137	42530634
Dyspepsia	33.27	13.79	4	48560	41348	42531423
Nocardiosis	33.16	13.79	35	48529	5155	42567616
Hallucinations, mixed	33	13.79	29	48535	3406	42569365
Hepatic failure	32.98	13.79	107	48457	37993	42534778
Acute graft versus host disease in liver	32.90	13.79	23	48541	1935	42570836
Infectious pleural effusion	32.77	13.79	28	48536	3167	42569604
Altered state of consciousness	32.75	13.79	90	48474	29169	42543602
Pyrexia	32.73	13.79	630	47934	393412	42179359
Central nervous system fungal infection	32.72	13.79	14	48550	439	42572332
BK virus infection	32.67	13.79	45	48519	8739	42564032
Gastrooesophageal reflux disease	32.45	13.79	6	48558	45017	42527754
Liver injury	32.29	13.79	69	48495	19079	42553692
Lung abscess	32.26	13.79	28	48536	3235	42569536
Vomiting	32.12	13.79	196	48368	289527	42283244
Cerebral fungal infection	31.83	13.79	13	48551	362	42572409
Hospitalisation	31.75	13.79	23	48541	74307	42498464
Product contamination microbial	31.73	13.79	16	48548	734	42572037
Drug hypersensitivity	31.67	13.79	40	48524	99349	42473422
Liver disorder	31.35	13.79	108	48456	39536	42533235
Haemophagocytic lymphohistiocytosis	31.11	13.79	66	48498	18156	42554615
Chromatopsia	30.97	13.79	12	48552	290	42572481
Enterococcal bacteraemia	30.73	13.79	25	48539	2642	42570129
Klebsiella infection	30.62	13.79	50	48514	11282	42561489
Torsade de pointes	30.43	13.79	43	48521	8551	42564220
Pulmonary mass	30.22	13.79	61	48503	16204	42556567
Malignant neoplasm progression	30.21	13.79	48	48516	108352	42464419
Mycotic endophthalmitis	30.09	13.79	11	48553	225	42572546
Post transplant lymphoproliferative disorder	29.90	13.79	44	48520	9076	42563695
Rheumatoid arthritis	29.86	13.79	6	48558	42434	42530337
Abdominal pain	29.74	13.79	114	48450	190357	42382414
Arthritis fungal	29.43	13.79	9	48555	103	42572668
Swelling	29.14	13.79	13	48551	54872	42517899
Chronic obstructive pulmonary disease	29.01	13.79	18	48546	63096	42509675
Neutropenia	29.01	13.79	351	48213	199080	42373691
Macular opacity	28.89	13.79	5	48559	0	42572771
Lower respiratory tract infection fungal	28.80	13.79	14	48550	593	42572178
Syncope	28.67	13.79	43	48521	99363	42473408
Venoocclusive liver disease	28.58	13.79	46	48518	10256	42562515
Eye infection fungal	28.56	13.79	13	48551	474	42572297
Neurological symptom	28.25	13.79	45	48519	9946	42562825
Microangiopathic haemolytic anaemia	27.92	13.79	17	48547	1130	42571641
Toxic skin eruption	27.33	13.79	53	48511	13677	42559094
Chronic graft versus host disease	27.27	13.79	34	48530	5991	42566780
Hypertrophic osteoarthropathy	26.96	13.79	8	48556	82	42572689
Tongue necrosis	26.74	13.79	7	48557	43	42572728
Pulmonary haemorrhage	26.45	13.79	47	48517	11350	42561421
Brain herniation	26.42	13.79	30	48534	4793	42567978
Dry skin	26.38	13.79	11	48553	48327	42524444
Renal impairment	26.26	13.79	215	48349	110013	42462758
Scopulariopsis infection	26.17	13.79	9	48555	153	42572618
Wrong technique in product usage process	26.17	13.79	8	48556	42627	42530144
Urinary tract inflammation	25.95	13.79	10	48554	238	42572533
Pulmonary cavitation	25.92	13.79	17	48547	1287	42571484
Gait disturbance	25.81	13.79	45	48519	97955	42474816
Eczema	25.76	13.79	4	48560	34082	42538689
Pneumonia	25.51	13.79	645	47919	421504	42151267
Trichosporon infection	25.49	13.79	15	48549	937	42571834
Lung infiltration	25.44	13.79	52	48512	13937	42558834
Dry mouth	25.36	13.79	7	48557	39872	42532899
Cerebrovascular accident	25.24	13.79	45	48519	97115	42475656
Ectropion	25.09	13.79	9	48555	174	42572597
Somnolence	25.01	13.79	80	48484	141025	42431746
Product use in unapproved indication	24.82	13.79	320	48244	184136	42388635
Transmission of an infectious agent via product	24.76	13.79	9	48555	181	42572590
Pneumonia bacterial	24.70	13.79	55	48509	15637	42557134
Sleep disorder	24.59	13.79	12	48552	48083	42524688
Angina pectoris	24.54	13.79	4	48560	32892	42539879
Deep vein thrombosis	24.49	13.79	31	48533	76926	42495845
Necrotising retinitis	24.40	13.79	15	48549	1015	42571756
Renal ischaemia	24.35	13.79	18	48546	1652	42571119
Pneumonia pseudomonal	24.32	13.79	29	48535	4880	42567891
Nephrolithiasis	24.31	13.79	6	48558	36824	42535947
Oropharyngeal pain	24.31	13.79	9	48555	42501	42530270
Fungal skin infection	24.00	13.79	24	48540	3317	42569454
Gallbladder empyema	23.93	13.79	7	48557	68	42572703
Cerebral ventricle collapse	23.82	13.79	8	48556	126	42572645
Weight increased	23.80	13.79	55	48509	107928	42464843
Antibiotic level below therapeutic	23.65	13.79	7	48557	71	42572700
Primary adrenal insufficiency	23.60	13.79	10	48554	306	42572465
Acute myocardial infarction	23.56	13.79	19	48545	58146	42514625
Memory impairment	23.53	13.79	14	48550	50208	42522563
Geotrichum infection	23.51	13.79	12	48552	565	42572206
Acute lymphocytic leukaemia	23.47	13.79	24	48540	3407	42569364
Wheezing	23.33	13.79	17	48547	54764	42518007
Drug dependence	22.95	13.79	3	48561	29091	42543680
Cytomegalovirus enterocolitis	22.66	13.79	16	48548	1367	42571404
Haematochezia	22.55	13.79	20	48544	58416	42514355
Inhibitory drug interaction	22.51	13.79	18	48546	1856	42570915
Splenic candidiasis	22.44	13.79	7	48557	86	42572685
Transaminases increased	22.12	13.79	85	48479	32800	42539971
Cytomegalovirus infection reactivation	22.07	13.79	43	48521	11135	42561636
Cystitis viral	21.83	13.79	15	48549	1227	42571544
Citrobacter infection	21.74	13.79	12	48552	663	42572108
Urinary bladder rupture	21.67	13.79	7	48557	97	42572674
Infection in an immunocompromised host	21.55	13.79	14	48550	1043	42571728
Pneumonia cytomegaloviral	21.48	13.79	25	48539	4101	42568670
Thrombosis	21.38	13.79	28	48536	68483	42504288
Hepatic enzyme increased	21.35	13.79	106	48458	45678	42527093
Renal failure	20.89	13.79	253	48311	143473	42429298
Cardiovascular insufficiency	20.79	13.79	17	48547	1809	42570962
Decreased appetite	20.68	13.79	132	48432	193005	42379766
Sunburn	20.61	13.79	18	48546	2097	42570674
Incorrect dose administered	20.60	13.79	18	48546	52956	42519815
Viral haemorrhagic cystitis	20.57	13.79	17	48547	1837	42570934
Blood cholesterol increased	20.52	13.79	3	48561	26738	42546033
Pallor	20.49	13.79	4	48560	28882	42543889
Abdominal discomfort	20.32	13.79	34	48530	75221	42497550
Granulomatous dermatitis	20.25	13.79	9	48555	310	42572461
Vertigo	20.10	13.79	7	48557	34340	42538431
Urinary tract infection	19.98	13.79	53	48511	99231	42473540
Colitis ulcerative	19.94	13.79	3	48561	26172	42546599
Abdominal pain upper	19.93	13.79	40	48524	82569	42490202
Aspiration bone marrow abnormal	19.88	13.79	7	48557	128	42572643
Coagulopathy	19.86	13.79	63	48501	22099	42550672
Dysbiosis	19.83	13.79	12	48552	789	42571982
Neck pain	19.59	13.79	5	48559	30009	42542762
Transplant rejection	19.58	13.79	46	48518	13542	42559229
Transient ischaemic attack	19.53	13.79	7	48557	33732	42539039
Bacterial sepsis	19.44	13.79	30	48534	6452	42566319
Lentigo	19.38	13.79	12	48552	822	42571949
Hypokalaemia	19.34	13.79	144	48420	71577	42501194
Arthritis	19.33	13.79	12	48552	42053	42530718
Retinal ischaemia	19.24	13.79	10	48554	489	42572282
Migraine	19.16	13.79	3	48561	25411	42547360
Nasal congestion	19.10	13.79	5	48559	29496	42543275
Staphylococcal sepsis	19.09	13.79	41	48523	11373	42561398
Burns first degree	19.08	13.79	4	48560	7	42572764
COVID-19	18.99	13.79	68	48496	115880	42456891
Disease progression	18.80	13.79	248	48316	143408	42429363
Blood beta-D-glucan increased	18.67	13.79	10	48554	520	42572251
Pneumothorax	18.49	13.79	64	48500	23479	42549292
Skin mass	18.40	13.79	25	48539	4791	42567980
Hypersensitivity	18.36	13.79	34	48530	72336	42500435
Dysgeusia	18.30	13.79	8	48556	34181	42538590
Ocular surface squamous neoplasia	18.29	13.79	5	48559	37	42572734
Malabsorption	18.25	13.79	19	48545	2754	42570017
Gastrointestinal fungal infection	18.18	13.79	8	48556	269	42572502
Haemoptysis	18.17	13.79	102	48462	46065	42526706
Osteoarthritis	18.13	13.79	3	48561	24402	42548369
Lactic acidosis	18.06	13.79	15	48549	45246	42527525
Neuroendocrine carcinoma of the skin	17.87	13.79	12	48552	945	42571826
Flushing	17.81	13.79	10	48554	37018	42535753
Escherichia sepsis	17.80	13.79	27	48537	5720	42567051
Pneumocystis jirovecii infection	17.76	13.79	19	48545	2841	42569930
Fungal test positive	17.69	13.79	10	48554	579	42572192
Neuropsychiatric symptoms	17.67	13.79	11	48553	761	42572010
Chills	17.60	13.79	52	48512	94014	42478757
Scintillating scotoma	17.43	13.79	5	48559	45	42572726
Rash	17.41	13.79	217	48347	276737	42296034
Nervous system disorder	17.39	13.79	51	48513	17144	42555627
Arthropathy	17.37	13.79	6	48558	29591	42543180
Bronchial artery embolisation	17.34	13.79	3	48561	0	42572771
Skin infection	17.21	13.79	35	48529	9345	42563426
Feeling hot	17.20	13.79	3	48561	23479	42549292
Acute lymphocytic leukaemia recurrent	16.98	13.79	21	48543	3670	42569101
Pulmonary resection	16.98	13.79	6	48558	111	42572660
Ureaplasma infection	16.97	13.79	10	48554	626	42572145
Chest discomfort	16.94	13.79	29	48535	63587	42509184
Oral papilloma	16.90	13.79	4	48560	15	42572756
Periostosis	16.90	13.79	4	48560	15	42572756
Apraxia	16.87	13.79	14	48550	1521	42571250
Unevaluable event	16.87	13.79	9	48555	34279	42538492
Therapeutic product effect decreased	16.86	13.79	12	48552	39138	42533633
Cerebral artery embolism	16.83	13.79	12	48552	1041	42571730
Urinary retention	16.83	13.79	14	48550	42200	42530571
Colour blindness acquired	16.83	13.79	6	48558	114	42572657
Suicidal ideation	16.83	13.79	18	48546	48143	42524628
Infective aneurysm	16.77	13.79	12	48552	1047	42571724
Blood culture negative	16.70	13.79	5	48559	53	42572718
Gastrointestinal wall thickening	16.62	13.79	15	48549	1824	42570947
Neurological decompensation	16.54	13.79	21	48543	3768	42569003
Diverticulitis	16.48	13.79	3	48561	22770	42550001
Retinal haemorrhage	16.33	13.79	26	48538	5744	42567027
Photoonycholysis	16.32	13.79	4	48560	18	42572753
Mucosal ulceration	16.25	13.79	13	48551	1341	42571430
Sepsis	16.23	13.79	318	48246	199016	42373755
Myocarditis infectious	16.21	13.79	5	48559	59	42572712
Complications of transplant surgery	16.14	13.79	9	48555	507	42572264
Conductive deafness	16.13	13.79	9	48555	508	42572263
Peptic ulcer haemorrhage	16.13	13.79	10	48554	687	42572084
Hyperbilirubinaemia	16.12	13.79	56	48508	20579	42552192
Staphylococcal infection	16.05	13.79	85	48479	37558	42535213
Musculoskeletal pain	16.04	13.79	9	48555	33331	42539440
Acanthamoeba infection	16.03	13.79	9	48555	514	42572257
Injury	16.02	13.79	3	48561	22313	42550458
CARD9 deficiency	15.97	13.79	4	48560	20	42572751
Retinal toxicity	15.97	13.79	9	48555	518	42572253
Therapy interrupted	15.96	13.79	3	48561	22247	42550524
Thoracic haemorrhage	15.94	13.79	7	48557	234	42572537
Enamel anomaly	15.94	13.79	7	48557	234	42572537
Gout	15.94	13.79	6	48558	28049	42544722
Blood glucose increased	15.87	13.79	38	48526	73661	42499110
Atypical mycobacterial pneumonia	15.86	13.79	7	48557	237	42572534
Inflammatory marker increased	15.86	13.79	28	48536	6728	42566043
Hepatitis toxic	15.85	13.79	17	48547	2550	42570221
Ocular toxicity	15.73	13.79	8	48556	374	42572397
Mental disorder due to a general medical condition	15.68	13.79	6	48558	140	42572631
Aspartate aminotransferase	15.64	13.79	6	48558	141	42572630
Palpitations	15.60	13.79	21	48543	50776	42521995
Gastrointestinal mucormycosis	15.55	13.79	8	48556	383	42572388
Graft versus host disease in lung	15.48	13.79	10	48554	738	42572033
Diabetes mellitus	15.45	13.79	28	48536	60059	42512712
General physical health deterioration	15.36	13.79	105	48459	151141	42421630
Cytokine release syndrome	15.35	13.79	95	48469	44432	42528339
Mycobacterium abscessus infection	15.33	13.79	10	48554	750	42572021
Choriomeningitis lymphocytic	15.33	13.79	6	48558	149	42572622
Hepatic infection fungal	15.28	13.79	7	48557	259	42572512
Chronic pulmonary histoplasmosis	15.26	13.79	3	48561	3	42572768
Proteus test positive	15.23	13.79	7	48557	261	42572510
Loss of consciousness	15.23	13.79	54	48510	92300	42480471
Neuroleptic malignant syndrome	15.18	13.79	3	48561	21469	42551302
Overdose	15.15	13.79	65	48499	105199	42467572
Atrial fibrillation	15.14	13.79	95	48469	139498	42433273
Lip ulceration	14.98	13.79	11	48553	999	42571772
Hepatomegaly	14.96	13.79	38	48526	11747	42561024
Death	14.92	13.79	416	48148	470769	42102002
Organ failure	14.78	13.79	16	48548	2424	42570347
Pneumomediastinum	14.77	13.79	18	48546	3098	42569673
Solar dermatitis	14.76	13.79	5	48559	81	42572690
Transverse sinus thrombosis	14.70	13.79	5	48559	82	42572689
Rhinorrhoea	14.70	13.79	9	48555	31785	42540986
Dysphagia	14.49	13.79	39	48525	72680	42500091
Chronic granulomatous disease	14.47	13.79	4	48560	31	42572740
Necrotising ulcerative gingivostomatitis	14.43	13.79	5	48559	87	42572684
Liver function test abnormal	14.40	13.79	74	48490	32317	42540454
Eye abscess	14.37	13.79	6	48558	177	42572594
Clostridium difficile colitis	14.34	13.79	55	48509	21197	42551574
Contusion	14.33	13.79	16	48548	41969	42530802
Drug level abnormal	14.32	13.79	7	48557	300	42572471
Hypotension	14.32	13.79	207	48357	257424	42315347
Head injury	14.29	13.79	3	48561	20579	42552192
Mycoplasma infection	14.28	13.79	9	48555	636	42572135
Ephelides	14.12	13.79	5	48559	93	42572678
Pneumonia aspiration	14.11	13.79	22	48542	50056	42522715
Melaena	14.08	13.79	14	48550	38732	42534039
Eustachian tube disorder	14.05	13.79	3	48561	6	42572765
Chronic kidney disease	14.04	13.79	20	48544	47221	42525550
Aplasia	13.95	13.79	22	48542	4821	42567950
Hypoxia	13.94	13.79	131	48433	69655	42503116
Posterior reversible encephalopathy syndrome	13.91	13.79	39	48525	12782	42559989
Chondritis	13.91	13.79	6	48558	192	42572579
Candida test positive	13.90	13.79	8	48556	479	42572292
Lymphopenia	13.90	13.79	55	48509	21508	42551263

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	1565.31	14.08	1810	73656	498373	110015460
Drug ineffective	1477.89	14.08	3204	72262	1517336	108996497
Bronchopulmonary aspergillosis	1134.81	14.08	504	74962	29359	110484474
Photosensitivity reaction	1073.36	14.08	463	75003	25126	110488707
Aspergillus infection	1066.33	14.08	461	75005	25155	110488678
Mucormycosis	914.92	14.08	324	75142	10304	110503529
Periostitis	888.29	14.08	185	75281	638	110513195
Drug level increased	869.73	14.08	489	74977	47230	110466603
Hallucination, visual	700.42	14.08	398	75068	39207	110474626
Actinic keratosis	685.22	14.08	235	75231	6778	110507055
Multiple organ dysfunction syndrome	681.23	14.08	667	74799	151043	110362790
Drug resistance	587.74	14.08	405	75061	55969	110457864
Squamous cell carcinoma of skin	545.19	14.08	256	75210	16947	110496886
Hallucination	494.81	14.08	467	74999	100965	110412868
Cerebral aspergillosis	454.60	14.08	132	75334	2170	110511663
Respiratory failure	453.23	14.08	642	74824	214690	110299143
Septic shock	433.89	14.08	536	74930	156992	110356841
Pneumonia fungal	402.12	14.08	198	75268	14556	110499277
Pathogen resistance	379.62	14.08	202	75264	17470	110496363
Hepatotoxicity	372.14	14.08	324	75142	63076	110450757
Fungal infection	371.75	14.08	295	75171	50511	110463322
Drug level below therapeutic	370.75	14.08	174	75292	11499	110502334
Systemic mycosis	319.13	14.08	114	75352	3715	110510118
Photodermatosis	318.50	14.08	85	75381	1006	110512827
Fatigue	317.54	14.08	222	75244	1215736	109298097
Drug level decreased	302.75	14.08	177	75289	18371	110495462
Pain	296.56	14.08	141	75325	954814	109559019
Febrile neutropenia	288.58	14.08	655	74811	316112	110197721
Scedosporium infection	286.19	14.08	94	75372	2364	110511469
Cholestasis	286.11	14.08	282	75184	64236	110449597
Squamous cell carcinoma	272.19	14.08	165	75301	18298	110495535
Graft versus host disease	269.38	14.08	165	75301	18641	110495192
Acute myeloid leukaemia	234.20	14.08	200	75266	37910	110475923
Hepatic function abnormal	233.15	14.08	296	75170	88999	110424834
Fusarium infection	225.28	14.08	81	75385	2690	110511143
Disorganised speech	222.22	14.08	84	75382	3219	110510614
Drug ineffective for unapproved indication	218.11	14.08	308	75158	102530	110411303
Neurotoxicity	216.57	14.08	200	75266	42007	110471826
Joint swelling	212.93	14.08	26	75440	442819	110071014
Pulmonary mucormycosis	206.16	14.08	71	75395	2072	110511761
Brain abscess	190.83	14.08	93	75373	6681	110507152
Toxic optic neuropathy	188.31	14.08	59	75407	1269	110512564
Solar lentigo	184.37	14.08	60	75406	1464	110512369
Fluoride increased	179.72	14.08	34	75432	59	110513774
Pruritus	172.46	14.08	91	75375	581469	109932364
Fluorosis	171.60	14.08	38	75428	187	110513646
Nasopharyngitis	171.49	14.08	31	75435	394330	110119503
Arthralgia	171.25	14.08	168	75298	779464	109734369
Pancytopenia	166.32	14.08	411	75055	209202	110304631
Arthropathy	166.11	14.08	7	75459	287515	110226318
Candida infection	164.72	14.08	183	75283	47826	110466007
Pseudomonas infection	164.69	14.08	143	75323	27710	110486123
Rheumatoid arthritis	161.56	14.08	11	75455	299602	110214231
Choroiditis	161.18	14.08	55	75411	1560	110512273
Drug level above therapeutic	159.16	14.08	99	75367	11489	110502344
Fungaemia	157.89	14.08	79	75387	6007	110507826
Visual impairment	157.10	14.08	308	75158	134120	110379713
Swelling	156.12	14.08	26	75440	351015	110162818
Immunosuppressant drug level increased	155.59	14.08	98	75368	11626	110502207
Synovitis	154.04	14.08	8	75458	274084	110239749
Peripheral swelling	151.32	14.08	44	75422	403990	110109843
Off label use	147.80	14.08	1616	73850	1498569	109015264
Musculoskeletal stiffness	145.96	14.08	12	75454	279810	110234023
Drug hypersensitivity	143.75	14.08	65	75401	454025	110059808
Fall	143.18	14.08	121	75345	603361	109910472
Nephropathy toxic	140.55	14.08	130	75336	27348	110486485
Enterococcal infection	139.87	14.08	114	75352	20252	110493581
Disseminated mucormycosis	139.76	14.08	53	75413	2049	110511784
Headache	136.77	14.08	246	75220	882131	109631702
Product dose omission issue	132.12	14.08	29	75437	321753	110192080
Pain in extremity	131.90	14.08	85	75381	487033	110026800
Hepatic cytolysis	130.42	14.08	174	75292	54879	110458954
Infusion related reaction	129.61	14.08	49	75417	381113	110132720
Abdominal discomfort	128.41	14.08	54	75412	393804	110120029
Cytomegalovirus infection	125.80	14.08	170	75296	54274	110459559
Wound	125.23	14.08	9	75457	234428	110279405
Malaise	123.37	14.08	167	75299	671652	109842181
Hypersensitivity	122.98	14.08	61	75405	403937	110109896
Graft versus host disease in gastrointestinal tract	121.61	14.08	76	75390	8892	110504941
Urticaria	120.70	14.08	34	75432	318823	110195010
Xanthopsia	117.97	14.08	31	75435	344	110513489
Fungal endocarditis	117.95	14.08	37	75429	799	110513034
Disseminated aspergillosis	117.63	14.08	49	75417	2431	110511402
Dysplastic naevus	117.43	14.08	37	75429	811	110513022
Therapeutic product effect decreased	115.75	14.08	15	75451	244301	110269532
Aspergilloma	115.40	14.08	36	75430	763	110513070
Dizziness	113.25	14.08	189	75277	698004	109815829
Anxiety	112.98	14.08	47	75419	345031	110168802
Neutropenia	111.84	14.08	529	74937	374091	110139742
Renal impairment	110.81	14.08	331	75135	188114	110325719
Acute respiratory distress syndrome	110.77	14.08	158	75308	53040	110460793
Osteoarthritis	110.54	14.08	3	75463	182620	110331213
Impaired healing	109.70	14.08	6	75460	196711	110317122
Aspergillus test positive	109.66	14.08	37	75429	1013	110512820
Systemic lupus erythematosus	108.36	14.08	21	75445	254317	110259516
Discomfort	107.16	14.08	11	75455	214696	110299137
Injury	106.97	14.08	3	75463	177262	110336571
Nausea	104.84	14.08	461	75005	1235229	109278604
Dyschromatopsia	102.10	14.08	37	75429	1257	110512576
Venoocclusive liver disease	102.07	14.08	84	75382	15123	110498710
Contraindicated product administered	100.63	14.08	23	75443	248244	110265589
Hepatocellular injury	100.47	14.08	147	75319	50495	110463338
Endophthalmitis	100.12	14.08	65	75401	8122	110505711
Pyrexia	99.00	14.08	991	74475	897274	109616559
Blood cholesterol increased	98.95	14.08	7	75459	184778	110329055
Mobility decreased	98.24	14.08	21	75445	237401	110276432
Injection site pain	97.46	14.08	6	75460	177916	110335917
Cytomegalovirus viraemia	96.63	14.08	87	75379	17677	110496156
Chloropsia	95.98	14.08	18	75448	29	110513804
Blood alkaline phosphatase increased	95.85	14.08	173	75293	70762	110443071
Alopecia	95.52	14.08	66	75400	364687	110149146
Drug abuse	94.20	14.08	7	75459	177404	110336429
Cheilitis	94.10	14.08	57	75409	6308	110507525
Type 2 diabetes mellitus	94.08	14.08	7	75459	177225	110336608
Weight increased	93.62	14.08	89	75377	419555	110094278
Pericarditis	93.53	14.08	18	75448	219096	110294737
Blood bilirubin increased	93.52	14.08	178	75288	75794	110438039
Dry mouth	92.98	14.08	13	75453	199935	110313898
Sepsis	92.43	14.08	455	75011	326891	110186942
Wheezing	91.54	14.08	30	75436	255200	110258633
Migraine	90.49	14.08	7	75459	171645	110342188
Gamma-glutamyltransferase increased	89.92	14.08	155	75311	61154	110452679
Visual acuity reduced	89.27	14.08	110	75356	32063	110481770
Delirium	87.87	14.08	246	75220	134779	110379054
Gastrooesophageal reflux disease	87.82	14.08	10	75456	179966	110333867
Hypertrophic osteoarthropathy	87.41	14.08	20	75446	117	110513716
Condition aggravated	87.40	14.08	824	74642	734012	109779821
Fibromyalgia	87.27	14.08	8	75458	170901	110342932
Haemophagocytic lymphohistiocytosis	86.12	14.08	107	75359	31452	110482381
Abdominal pain upper	85.17	14.08	68	75398	349043	110164790
Product use in unapproved indication	83.64	14.08	557	74909	446820	110067013
Disease progression	83.54	14.08	359	75107	243675	110270158
Mental disorder	83.40	14.08	117	75349	38674	110475159
Blood pressure increased	83.25	14.08	36	75430	258337	110255496
Dyspepsia	82.97	14.08	15	75451	190950	110322883
Graft versus host disease in skin	82.90	14.08	58	75408	8196	110505637
Folliculitis	82.60	14.08	9	75457	167644	110346189
Acute graft versus host disease	81.99	14.08	69	75397	12812	110501021
Hypertension	81.78	14.08	139	75327	509945	110003888
Phaeohyphomycosis	81.75	14.08	34	75432	1680	110512153
Dilatation intrahepatic duct acquired	81.36	14.08	28	75438	815	110513018
Asthma	80.44	14.08	35	75431	250256	110263577
Acute graft versus host disease in skin	79.88	14.08	63	75403	10677	110503156
Maternal exposure during pregnancy	79.79	14.08	37	75429	254846	110258987
Contusion	79.28	14.08	30	75436	233331	110280502
Staphylococcal infection	77.75	14.08	157	75309	69787	110444046
Exposure during pregnancy	77.58	14.08	11	75455	167413	110346420
Pneumonia	77.06	14.08	925	74541	875789	109638044
Muscle injury	76.36	14.08	5	75461	140802	110373031
Diarrhoea	76.25	14.08	461	75005	1139044	109374789
Asthenia	76.10	14.08	230	75236	688769	109825064
Torsade de pointes	75.54	14.08	85	75381	22515	110491318
Dyspnoea	75.53	14.08	445	75021	1106427	109407406
C-reactive protein abnormal	75.40	14.08	3	75463	129692	110384141
Geotrichum infection	74.99	14.08	29	75437	1183	110512650
Hepatitis cholestatic	74.54	14.08	75	75391	17491	110496342
Leukaemia recurrent	73.52	14.08	38	75428	3093	110510740
Acute myeloid leukaemia recurrent	73.36	14.08	45	75421	5094	110508739
Muscle spasms	73.24	14.08	50	75416	278107	110235726
Pneumonia bacterial	73.20	14.08	90	75376	26171	110487662
Stenotrophomonas infection	72.84	14.08	47	75419	5811	110508022
Lower respiratory tract infection	72.00	14.08	38	75428	243068	110270765
Rash	70.82	14.08	304	75162	820660	109693173
Cerebral fungal infection	69.99	14.08	24	75442	691	110513142
Klebsiella infection	69.87	14.08	77	75389	19932	110493901
Fungal test positive	69.85	14.08	27	75439	1100	110512733
Drug-induced liver injury	69.69	14.08	210	75256	119857	110393976
Chest pain	69.54	14.08	93	75373	376282	110137551
Acute graft versus host disease in intestine	69.52	14.08	45	75421	5594	110508239
Bursitis	69.33	14.08	5	75461	129913	110383920
Back pain	69.23	14.08	91	75375	370905	110142928
Renal failure	68.29	14.08	321	75145	226253	110287580
Disseminated intravascular coagulation	68.05	14.08	110	75356	41176	110472657
Halo vision	67.75	14.08	23	75443	642	110513191
Lentigo	67.70	14.08	24	75442	764	110513069
Electrocardiogram QT prolonged	67.46	14.08	195	75271	108765	110405068
Pneumothorax	66.50	14.08	100	75366	35185	110478648
Altered state of consciousness	66.02	14.08	131	75335	57495	110456338
Nervous system disorder	65.72	14.08	94	75372	31627	110482206
Septic embolus	65.71	14.08	32	75434	2294	110511539
Lip squamous cell carcinoma	65.61	14.08	19	75447	309	110513524
Posterior reversible encephalopathy syndrome	65.30	14.08	97	75369	33764	110480069
Osteomyelitis fungal	64.96	14.08	20	75446	405	110513428
Inappropriate schedule of product administration	64.60	14.08	29	75437	203608	110310225
Encephalopathy	64.27	14.08	159	75307	80896	110432937
Mediastinitis	64.03	14.08	27	75439	1381	110512452
Sleep disorder	63.47	14.08	28	75438	198616	110315217
Psoriasis	63.01	14.08	10	75456	139983	110373850
Sinusitis	62.61	14.08	66	75400	296622	110217211
Intraocular pressure increased	62.60	14.08	55	75411	10821	110503012
Acute graft versus host disease in liver	62.31	14.08	31	75435	2328	110511505
Obesity	61.54	14.08	4	75462	113347	110400486
Platelet count decreased	61.25	14.08	315	75151	230128	110283705
Chronic graft versus host disease	60.89	14.08	51	75415	9406	110504427
Acute kidney injury	60.89	14.08	682	74784	634748	109879085
Ill-defined disorder	60.68	14.08	16	75450	156837	110356996
Loss of personal independence in daily activities	60.57	14.08	14	75452	150006	110363827
Nocardiosis	60.22	14.08	46	75420	7440	110506393
Depression	60.06	14.08	77	75389	317258	110196575
Abscess fungal	59.44	14.08	19	75447	437	110513396
Chromatopsia	59.14	14.08	21	75445	672	110513161
Musculoskeletal pain	58.16	14.08	26	75440	182997	110330836
Central nervous system fungal infection	57.51	14.08	20	75446	601	110513232
Weight decreased	56.98	14.08	149	75317	467908	110045925
Pulmonary haemorrhage	56.90	14.08	63	75403	16393	110497440
Skin candida	56.82	14.08	29	75437	2299	110511534
Hypokalaemia	56.82	14.08	261	75205	182187	110331646
Haemoptysis	56.61	14.08	140	75326	71214	110442619
Photopsia	56.28	14.08	41	75425	6173	110507660
Pulmonary alveolar haemorrhage	56.07	14.08	69	75397	20081	110493752
BK virus infection	55.69	14.08	56	75410	13050	110500783
Vomiting	55.42	14.08	379	75087	910296	109603537
Cystitis haemorrhagic	55.27	14.08	54	75412	12155	110501678
Suicide attempt	55.11	14.08	4	75462	103390	110410443
Neck pain	54.96	14.08	9	75457	123121	110390712
Neutrophil count decreased	54.42	14.08	194	75272	120747	110393086
Myocardial infarction	54.02	14.08	32	75434	192051	110321782
Product compounding quality issue	53.25	14.08	11	75455	36	110513797
Rectal haemorrhage	52.95	14.08	9	75457	119824	110394009
Bone marrow failure	52.94	14.08	120	75346	57728	110456105
Infective aneurysm	52.86	14.08	24	75442	1468	110512365
Photophobia	52.84	14.08	76	75390	25695	110488138
Central nervous system lesion	52.84	14.08	59	75407	15494	110498339
Fungal skin infection	52.79	14.08	42	75424	7207	110506626
Post transplant lymphoproliferative disorder	52.65	14.08	59	75407	15554	110498279
Gait inability	52.59	14.08	14	75452	136362	110377471
Road traffic accident	52.30	14.08	6	75460	107392	110406441
Mycotic endophthalmitis	51.69	14.08	17	75449	429	110513404
Brain oedema	51.45	14.08	83	75383	31015	110482818
Cytomegalovirus infection reactivation	51.37	14.08	63	75403	18270	110495563
Lower respiratory tract infection fungal	51.23	14.08	20	75446	837	110512996
Lung infiltration	51.04	14.08	73	75393	24555	110489278
Sciatica	50.94	14.08	3	75463	92396	110421437
Pleural effusion	50.80	14.08	248	75218	177461	110336372
Necrosis	50.80	14.08	50	75416	11356	110502477
Systemic candida	50.64	14.08	47	75419	9927	110503906
Dysphoria	50.61	14.08	39	75427	6389	110507444
Abdominal pain	50.53	14.08	180	75286	512809	110001024
Toxoplasmosis	50.46	14.08	30	75436	3209	110510624
Intentional overdose	50.34	14.08	14	75452	132487	110381346
Hypercholesterolaemia	49.93	14.08	3	75463	90834	110422999
Acute lymphocytic leukaemia	49.87	14.08	37	75429	5728	110508105
Sinusitis fungal	49.85	14.08	28	75438	2692	110511141
Enterococcal sepsis	49.84	14.08	30	75436	3282	110510551
Trichosporon infection	49.53	14.08	22	75444	1278	110512555
Brain herniation	49.37	14.08	44	75422	8819	110505014
Injection site erythema	49.18	14.08	4	75462	94172	110419661
Pseudoporphyria	48.92	14.08	19	75447	784	110513049
Pneumonia necrotising	48.89	14.08	24	75442	1751	110512082
Memory impairment	48.46	14.08	38	75428	196906	110316927
Infectious pleural effusion	48.26	14.08	34	75432	4857	110508976
Lip dry	47.73	14.08	6	75460	100077	110413756
Stomatitis	47.67	14.08	69	75397	270173	110243660
Lung abscess	47.51	14.08	34	75432	4978	110508855
Alanine aminotransferase increased	47.30	14.08	249	75217	183524	110330309
Infection in an immunocompromised host	47.02	14.08	24	75442	1903	110511930
Treatment failure	46.90	14.08	337	75129	276897	110236936
Transaminases increased	46.76	14.08	121	75345	63269	110450564
Stress	46.35	14.08	8	75458	105340	110408493
Corneal perforation	45.72	14.08	19	75447	937	110512896
Cytokine release syndrome	45.63	14.08	128	75338	70178	110443655
Acute lymphocytic leukaemia recurrent	45.32	14.08	35	75431	5752	110508081
Pneumonia pseudomonal	45.12	14.08	39	75427	7507	110506326
Alternaria infection	44.67	14.08	19	75447	993	110512840
Polyserositis	44.28	14.08	19	75447	1015	110512818
Pulmonary mass	44.18	14.08	86	75380	37215	110476618
Aspartate aminotransferase increased	44.15	14.08	221	75245	159715	110354118
Hypoxia	43.87	14.08	190	75276	129325	110384508
Hepatic failure	43.49	14.08	124	75342	68615	110445218
Injection site reaction	43.31	14.08	5	75461	89065	110424768
Liver function test abnormal	43.25	14.08	124	75342	68826	110445007
Thrombotic microangiopathy	43.13	14.08	74	75392	29075	110484758
Bronchial anastomosis complication	42.99	14.08	11	75455	109	110513724
Renal abscess	42.74	14.08	21	75445	1535	110512298
Eye infection fungal	42.42	14.08	16	75450	609	110513224
Blood beta-D-glucan increased	42.36	14.08	17	75449	766	110513067
Hypoaesthesia	42.18	14.08	95	75371	314128	110199705
Ovarian failure	42.01	14.08	18	75448	958	110512875
Urinary tract infection	41.91	14.08	101	75365	326181	110187652
Tracheobronchitis	41.90	14.08	25	75441	2691	110511142
Cerebral haemorrhage	41.88	14.08	118	75348	64850	110448983
Constipation	41.19	14.08	117	75349	357669	110156164
Night sweats	41.07	14.08	20	75446	133963	110379870
Hallucinations, mixed	40.38	14.08	39	75427	8654	110505179
Ocular surface squamous neoplasia	40.32	14.08	8	75458	20	110513813
Shock	40.26	14.08	103	75363	53485	110460348
Product contamination microbial	40.04	14.08	18	75448	1076	110512757
Neurological decompensation	40.00	14.08	35	75431	6848	110506985
Gliosis	39.97	14.08	16	75450	716	110513117
Feeling hot	39.90	14.08	7	75459	91099	110422734
Transplant rejection	39.86	14.08	65	75401	24502	110489331
Human polyomavirus infection	39.83	14.08	21	75445	1781	110512052
Toxic skin eruption	39.60	14.08	69	75397	27446	110486387
Dehiscence	39.43	14.08	16	75450	742	110513091
Arthritis	39.16	14.08	34	75432	167552	110346281
Drug intolerance	39.11	14.08	144	75322	406368	110107465
Intentional product misuse	39.00	14.08	21	75445	132883	110380950
Immunosuppressant drug level decreased	38.88	14.08	24	75442	2747	110511086
Inappropriate antidiuretic hormone secretion	38.83	14.08	77	75389	33774	110480059
Palpitations	38.81	14.08	31	75435	159181	110354652
Oropharyngeal pain	38.79	14.08	22	75444	135254	110378579
Uveitis	38.75	14.08	60	75406	21650	110492183
Pneumomediastinum	38.44	14.08	30	75436	5006	110508827
Mixed liver injury	37.95	14.08	44	75422	12035	110501798
Bacterial sepsis	37.93	14.08	41	75425	10385	110503448
Insomnia	37.88	14.08	123	75343	360467	110153366
Macular opacity	37.74	14.08	6	75460	0	110513833
Enterococcal bacteraemia	37.18	14.08	28	75438	4433	110509400
Transmission of an infectious agent via product	37.15	14.08	11	75455	194	110513639
Coagulopathy	36.47	14.08	84	75382	40827	110473006
Neurological symptom	36.44	14.08	49	75417	15559	110498274
Mycobacterium avium complex infection	36.41	14.08	31	75435	5846	110507987
Flushing	36.34	14.08	13	75453	104723	110409110
Scintillating scotoma	35.95	14.08	11	75455	218	110513615
Hyperbilirubinaemia	35.46	14.08	70	75396	30601	110483232
Intracranial infection	35.31	14.08	12	75454	336	110513497
Mycobacterium abscessus infection	35.22	14.08	19	75447	1687	110512146
Hypertransaminasaemia	35.13	14.08	61	75405	24194	110489639
Blister	34.54	14.08	64	75402	227312	110286521
Premature menopause	34.53	14.08	16	75450	1026	110512807
Sunburn	34.52	14.08	27	75439	4521	110509312
Eye abscess	34.40	14.08	12	75454	364	110513469
Upper respiratory tract infection	34.03	14.08	24	75442	131304	110382529
Scopulariopsis infection	33.96	14.08	10	75456	173	110513660
Pneumonia cytomegaloviral	33.82	14.08	32	75434	6922	110506911
Product quality issue	33.72	14.08	6	75460	77293	110436540
Adverse event	33.72	14.08	16	75450	108793	110405040
Citrobacter infection	33.34	14.08	17	75449	1345	110512488
Acinetobacter infection	33.32	14.08	24	75442	3549	110510284
Lung transplant rejection	33.02	14.08	19	75447	1912	110511921
Blood pressure systolic increased	32.99	14.08	8	75458	82983	110430850
Fungal sepsis	32.98	14.08	20	75446	2217	110511616
Pouchitis	32.93	14.08	17	75449	1380	110512453
Microangiopathic haemolytic anaemia	32.91	14.08	19	75447	1924	110511909
Cytopenia	32.74	14.08	67	75399	30049	110483784
Cytomegalovirus enterocolitis	32.62	14.08	20	75446	2261	110511572
Arthritis fungal	32.55	14.08	10	75456	201	110513632
Pericarditis fungal	32.54	14.08	11	75455	303	110513530
Rash maculo-papular	32.48	14.08	118	75348	74104	110439729
Mental status changes	32.45	14.08	120	75346	76002	110437831
Red blood cell sedimentation rate increased	32.22	14.08	7	75459	78295	110435538
Anaphylactic reaction	32.19	14.08	19	75447	114281	110399552
Joint stiffness	32.14	14.08	4	75462	67239	110446594
Pseudoaldosteronism	32.13	14.08	11	75455	315	110513518
Cystitis viral	32.08	14.08	17	75449	1456	110512377
Myoclonus	31.93	14.08	70	75396	32928	110480905
Hyperhidrosis	31.88	14.08	49	75417	187249	110326584
Hepatic infection fungal	31.71	14.08	11	75455	328	110513505
Escherichia sepsis	31.57	14.08	37	75429	10235	110503598
Graft versus host disease in lung	31.43	14.08	16	75450	1262	110512571
Skin mass	31.24	14.08	36	75430	9780	110504053
Chest discomfort	31.03	14.08	44	75422	173804	110340029
Pneumocystis jirovecii infection	30.99	14.08	25	75441	4375	110509458
Basal cell carcinoma	30.94	14.08	84	75382	45186	110468647
Respiratory tract infection fungal	30.89	14.08	16	75450	1308	110512525
Hospitalisation	30.83	14.08	31	75435	142462	110371371
Depressed mood	30.63	14.08	3	75463	60806	110453027
Aplasia	30.48	14.08	32	75434	7841	110505992
Pulmonary embolism	30.30	14.08	63	75403	214411	110299422
Hallucination, auditory	30.22	14.08	60	75406	26337	110487496
Pulmonary fibrosis	30.12	14.08	16	75450	102026	110411807
Syncope	29.89	14.08	58	75408	202478	110311355
Gastrointestinal mucormycosis	29.72	14.08	13	75453	728	110513105
Inflammation	29.70	14.08	54	75412	193184	110320649
Nasal congestion	29.62	14.08	15	75451	98267	110415566
Rhinocerebral mucormycosis	28.85	14.08	16	75450	1501	110512332
Conductive deafness	28.84	14.08	10	75456	298	110513535
Retinal haemorrhage	28.83	14.08	34	75432	9467	110504366
Graft versus host disease in liver	28.75	14.08	19	75447	2446	110511387
Eczema	28.68	14.08	7	75459	72286	110441547
Acanthamoeba infection	28.51	14.08	12	75454	611	110513222
Procalcitonin increased	28.47	14.08	23	75443	4033	110509800
Blood creatinine increased	28.45	14.08	218	75248	182671	110331162
Infection reactivation	28.35	14.08	23	75443	4058	110509775
Pulmonary cavitation	28.26	14.08	18	75448	2176	110511657
Feeling abnormal	28.22	14.08	50	75416	180661	110333172
Cardiac failure congestive	28.18	14.08	37	75429	150963	110362870
Leukaemia	28.12	14.08	30	75436	7488	110506345
Potentiating drug interaction	27.87	14.08	37	75429	11606	110502227
Erythropsia	27.48	14.08	7	75459	68	110513765
Dry skin	27.46	14.08	20	75446	107633	110406200
Differentiation syndrome	27.37	14.08	20	75446	3024	110510809
Vision blurred	27.35	14.08	166	75300	128856	110384977
Renal ischaemia	27.32	14.08	18	75448	2305	110511528
Wound infection	27.21	14.08	16	75450	96449	110417384
Bacterial infection	27.15	14.08	81	75385	45955	110467878
Toxic encephalopathy	27.09	14.08	42	75424	15172	110498661
Immune recovery uveitis	26.97	14.08	8	75458	142	110513691
Tonsillitis bacterial	26.97	14.08	9	75457	238	110513595
Colour blindness acquired	26.92	14.08	8	75458	143	110513690
Mucosal inflammation	26.62	14.08	133	75333	96008	110417825
Capillary leak syndrome	26.62	14.08	24	75442	4884	110508949
Dermatitis bullous	26.59	14.08	45	75421	17484	110496349
Hepatosplenomegaly	26.57	14.08	28	75438	6891	110506942
Nail disorder	26.38	14.08	4	75462	57931	110455902
Urinary tract inflammation	26.33	14.08	10	75456	388	110513445
Dysbiosis	26.25	14.08	17	75449	2115	110511718
Cytomegalovirus test positive	26.18	14.08	28	75438	7008	110506825
Lung consolidation	26.17	14.08	34	75432	10442	110503391
Ileus paralytic	26.12	14.08	36	75430	11701	110502132
Gastrointestinal fungal infection	25.93	14.08	12	75454	767	110513066
Splenic candidiasis	25.84	14.08	7	75459	88	110513745
General physical health deterioration	25.78	14.08	177	75289	425118	110088715
Eye pain	25.72	14.08	84	75382	50015	110463818
Dyspnoea exertional	25.69	14.08	20	75446	104040	110409793
Chronic obstructive pulmonary disease	25.68	14.08	22	75444	109136	110404697
Illness	25.59	14.08	12	75454	82159	110431674
Necrotising retinitis	25.43	14.08	15	75451	1581	110512252
Bacteraemia	25.40	14.08	75	75391	42315	110471518
Aspiration bone marrow abnormal	25.36	14.08	8	75458	176	110513657
Cortical visual impairment	25.30	14.08	6	75460	42	110513791
Upper airway necrosis	25.30	14.08	6	75460	42	110513791
Cerebral ventricle collapse	25.23	14.08	8	75458	179	110513654
Primary adrenal insufficiency	25.20	14.08	11	75455	613	110513220
Ocular toxicity	25.13	14.08	14	75452	1324	110512509
Amnesia	25.09	14.08	21	75445	105387	110408446
Coccidioidomycosis	25.08	14.08	15	75451	1622	110512211
Organ failure	25.04	14.08	23	75443	4794	110509039
Clostridium difficile colitis	24.85	14.08	76	75390	43702	110470131
Leukopenia	24.64	14.08	180	75286	148611	110365222
Hyperammonaemia	24.58	14.08	38	75428	13694	110500139
Oliguria	24.56	14.08	45	75421	18612	110495221
Pregnancy	24.50	14.08	3	75463	51064	110462769
Strongyloidiasis	24.36	14.08	23	75443	4963	110508870
Rhabdomyolysis	24.32	14.08	153	75313	120248	110393585
Meningitis fungal	24.18	14.08	9	75457	330	110513503
Hepatic candidiasis	24.16	14.08	7	75459	114	110513719
Paraesthesia	24	14.08	102	75364	276419	110237414
Proctectomy	23.95	14.08	9	75457	339	110513494
Gait disturbance	23.91	14.08	103	75363	278105	110235728
Medication error	23.86	14.08	22	75444	105344	110408489
Infective pulmonary exacerbation of cystic fibrosis	23.85	14.08	39	75427	14732	110499101
Rhinorrhoea	23.77	14.08	21	75445	102645	110411188
Antiphospholipid syndrome	23.65	14.08	17	75449	2506	110511327
Tongue necrosis	23.41	14.08	7	75459	128	110513705
Viral haemorrhagic cystitis	23.28	14.08	19	75447	3380	110510453
Gallbladder empyema	23.25	14.08	7	75459	131	110513702
Ureaplasma infection	23.25	14.08	14	75452	1532	110512301
Chronic graft versus host disease in skin	23.08	14.08	17	75449	2602	110511231
Haematochezia	22.92	14.08	27	75439	115497	110398336
Hemiparesis	22.89	14.08	74	75392	43829	110470004
Haemodynamic instability	22.65	14.08	49	75417	22839	110490994
Osteonecrosis of jaw	22.60	14.08	3	75463	48014	110465819
Colour blindness	22.53	14.08	10	75456	580	110513253
Respiratory distress	22.52	14.08	100	75366	68774	110445059
Agitation	22.43	14.08	143	75323	112908	110400925
Human herpesvirus 6 infection	22.41	14.08	25	75441	6556	110507277
Mucosal ulceration	22.23	14.08	16	75450	2363	110511470
Organising pneumonia	22.19	14.08	37	75429	14206	110499627
Transient ischaemic attack	22.09	14.08	8	75458	63974	110449859
Agranulocytosis	21.98	14.08	92	75374	61668	110452165
Apallic syndrome	21.95	14.08	12	75454	1094	110512739
Splenic infection fungal	21.86	14.08	7	75459	162	110513671
Urinary bladder rupture	21.82	14.08	7	75459	163	110513670
Angioedema	21.80	14.08	21	75445	98479	110415354
Aspergillus test	21.75	14.08	6	75460	81	110513752
Cardiovascular insufficiency	21.73	14.08	18	75448	3270	110510563
Neuroendocrine carcinoma of the skin	21.69	14.08	14	75452	1731	110512102
Adverse drug reaction	21.67	14.08	24	75442	105535	110408298
Staphylococcal bacteraemia	21.65	14.08	40	75426	16648	110497185
Throat irritation	21.61	14.08	5	75461	53547	110460286
Drug dependence	21.56	14.08	4	75462	50016	110463817
Therapy interrupted	21.44	14.08	4	75462	49818	110464015
Onychomadesis	21.14	14.08	3	75463	45660	110468173
Cerebrovascular accident	21.05	14.08	59	75407	181225	110332608
Granuloma	20.96	14.08	29	75437	9461	110504372
Fungal disease carrier	20.93	14.08	9	75457	483	110513350
Tumour lysis syndrome	20.89	14.08	57	75409	30744	110483089
Stem cell transplant	20.83	14.08	20	75446	4407	110509426
Epstein-Barr virus infection	20.74	14.08	42	75424	18696	110495137
Rhodococcus infection	20.69	14.08	9	75457	497	110513336
Functional residual capacity increased	20.64	14.08	6	75460	99	110513734
Gastrointestinal disorder	20.53	14.08	90	75376	241862	110271971
Adenovirus infection	20.49	14.08	31	75435	10963	110502870
Sedation	20.46	14.08	11	75455	69672	110444161
Granulomatous liver disease	20.42	14.08	13	75453	1571	110512262
Granulomatous dermatitis	20.36	14.08	9	75457	517	110513316
Ectropion	20.29	14.08	9	75457	521	110513312
Primary myelofibrosis	20.27	14.08	7	75459	206	110513627
Neuropsychiatric symptoms	20.25	14.08	12	75454	1276	110512557
Retinal ischaemia	20.19	14.08	11	75455	996	110512837
Swollen tongue	20.09	14.08	8	75458	60354	110453479
Wrong technique in product usage process	20.07	14.08	18	75448	87330	110426503
Klebsiella sepsis	19.99	14.08	19	75447	4134	110509699
Immune reconstitution inflammatory syndrome	19.94	14.08	38	75428	16188	110497645
Venoocclusive disease	19.73	14.08	23	75443	6327	110507506
Disease recurrence	19.68	14.08	88	75378	60696	110453137
Suicidal ideation	19.68	14.08	21	75445	93916	110419917
Angina pectoris	19.55	14.08	9	75457	62286	110451547
Escherichia bacteraemia	19.43	14.08	29	75437	10135	110503698
Chronic granulomatous disease	19.41	14.08	5	75461	51	110513782
Influenza like illness	19.39	14.08	19	75447	88393	110425440
Enamel anomaly	19.34	14.08	7	75459	237	110513596
Dry eye	19.22	14.08	7	75459	55786	110458047
Necrotising colitis	19.13	14.08	13	75453	1752	110512081
Hepatomegaly	19.12	14.08	44	75422	21370	110492463
Pseudomonal sepsis	19.02	14.08	27	75439	9019	110504814
Muscular weakness	18.98	14.08	96	75370	248372	110265461
Blastomycosis	18.96	14.08	11	75455	1124	110512709
Periostosis	18.94	14.08	4	75462	15	110513818
Live birth	18.94	14.08	12	75454	69472	110444361
Rhinovirus infection	18.87	14.08	31	75435	11758	110502075
Solar dermatitis	18.85	14.08	7	75459	255	110513578
Immunosuppression	18.71	14.08	39	75427	17720	110496113
Renal disorder	18.63	14.08	75	75391	49404	110464429
Apraxia	18.59	14.08	17	75449	3523	110510310
Septal panniculitis	18.57	14.08	6	75460	143	110513690
Mental disorder due to a general medical condition	18.52	14.08	7	75459	268	110513565
Disseminated cryptococcosis	18.51	14.08	15	75451	2642	110511191
Pain in jaw	18.36	14.08	6	75460	51171	110462662
Deafness bilateral	18.28	14.08	15	75451	2689	110511144
Somatic symptom disorder	18.23	14.08	16	75450	3143	110510690
Drug clearance decreased	18.23	14.08	18	75448	4104	110509729
Visual field defect	18.20	14.08	28	75438	10044	110503789
Dehydration	18.10	14.08	114	75352	279397	110234436
Back injury	18.02	14.08	5	75461	47394	110466439
CARD9 deficiency	18.01	14.08	4	75462	20	110513813
Antithrombin III deficiency	17.97	14.08	6	75460	159	110513674
Dysgeusia	17.85	14.08	13	75453	69972	110443861
Haemothorax	17.85	14.08	23	75443	7008	110506825
Ear pain	17.80	14.08	7	75459	53219	110460614
Burkholderia cepacia complex infection	17.75	14.08	8	75458	481	110513352
Osteoporosis	17.69	14.08	20	75446	87132	110426701
Blast cell count increased	17.61	14.08	12	75454	1625	110512208
Pseudallescheria infection	17.40	14.08	4	75462	24	110513809
Endocarditis	17.28	14.08	32	75434	13339	110500494
Gastric perforation	17.26	14.08	19	75447	4910	110508923
Choriomeningitis lymphocytic	17.26	14.08	6	75460	180	110513653
Atypical mycobacterial pneumonia	17.24	14.08	7	75459	325	110513508
Imprisonment	17.21	14.08	9	75457	750	110513083
Candida test positive	17.16	14.08	11	75455	1344	110512489
Intentional product use issue	17.16	14.08	99	75367	247807	110266026
Cardiac tamponade	17.12	14.08	29	75437	11278	110502555
Laryngitis	17.03	14.08	4	75462	42407	110471426
Dysphonia	17.02	14.08	16	75450	75913	110437920
Complications of transplant surgery	16.99	14.08	9	75457	770	110513063
Decreased appetite	16.88	14.08	226	75240	475620	110038213
Pulmonary resection	16.84	14.08	6	75460	194	110513639
Diabetic ketoacidosis	16.82	14.08	4	75462	42054	110471779
Chronic pulmonary histoplasmosis	16.79	14.08	3	75463	3	110513830
Exserohilum infection	16.79	14.08	3	75463	3	110513830
Heart rate decreased	16.79	14.08	19	75447	82737	110431096
Photoonycholysis	16.74	14.08	4	75462	29	110513804
Drug level abnormal	16.62	14.08	8	75458	559	110513274
Acute lymphocytic leukaemia refractory	16.61	14.08	6	75460	202	110513631
Pulmonary nocardiosis	16.56	14.08	14	75452	2615	110511218
Blood lactate dehydrogenase increased	16.53	14.08	67	75399	44267	110469566
Gastrointestinal polyp	16.52	14.08	6	75460	205	110513628
Drug withdrawal syndrome	16.50	14.08	3	75463	38051	110475782
Labelled drug-drug interaction issue	16.47	14.08	17	75449	4084	110509749
Ventricular extrasystoles	16.47	14.08	43	75423	22598	110491235
Ileostomy closure	16.45	14.08	7	75459	366	110513467
Corneal bleeding	16.40	14.08	4	75462	32	110513801
Pseudomembranous colitis	16.37	14.08	21	75445	6370	110507463
Mucosal necrosis	16.36	14.08	6	75460	211	110513622
Pneumocystis jirovecii pneumonia	16.27	14.08	65	75401	42670	110471163
Incorrect route of product administration	16.21	14.08	12	75454	64049	110449784
Exophthalmos	16.19	14.08	13	75453	2260	110511573
Burns first degree	16.18	14.08	4	75462	34	110513799
Liver abscess	16.13	14.08	23	75443	7716	110506117
Fungal abscess central nervous system	16.10	14.08	6	75460	221	110513612
Osteitis deformans	16.10	14.08	6	75460	221	110513612
Lactic acidosis	16.06	14.08	24	75442	92787	110421046
Peptic ulcer haemorrhage	16.05	14.08	10	75456	1163	110512670
Encephalitis	16.04	14.08	38	75428	18801	110495032
Torticollis	16.01	14.08	15	75451	3206	110510627
Tuberculosis gastrointestinal	15.99	14.08	8	75458	608	110513225
Obliterative bronchiolitis	15.99	14.08	16	75450	3707	110510126
Herpes simplex	15.89	14.08	34	75432	15730	110498103
Anal infection	15.84	14.08	6	75460	231	110513602
Engraftment syndrome	15.82	14.08	12	75454	1920	110511913
Prescribed overdose	15.79	14.08	22	75444	87559	110426274
Dermatitis exfoliative	15.74	14.08	28	75438	11319	110502514
Pythium insidiosum infection	15.58	14.08	3	75463	6	110513827
Penicillium infection	15.57	14.08	8	75458	643	110513190
Bronchitis	15.49	14.08	55	75411	156977	110356856
Oxygen saturation decreased	15.48	14.08	55	75411	156927	110356906
Rash pruritic	15.43	14.08	27	75439	98042	110415791
Hepatosplenic candidiasis	15.40	14.08	8	75458	658	110513175
Depressed level of consciousness	15.37	14.08	130	75336	112148	110401685
Keratitis fungal	15.36	14.08	7	75459	432	110513401
Complications of transplanted kidney	15.33	14.08	22	75444	7420	110506413
Respiratory acidosis	15.32	14.08	31	75435	13795	110500038
Skin cancer	15.29	14.08	36	75430	17748	110496085
Bilirubin conjugated increased	15.24	14.08	20	75446	6204	110507629
Bone marrow transplant	15.14	14.08	11	75455	1649	110512184
Respirovirus test positive	15.10	14.08	5	75461	129	110513704
Hepatic enzyme increased	15.08	14.08	143	75323	320749	110193084
Myocarditis infectious	15.06	14.08	5	75461	130	110513703
Disorientation	15.02	14.08	91	75375	70580	110443253
Stupor	14.97	14.08	23	75443	8242	110505591
Diverticulitis	14.92	14.08	9	75457	53513	110460320
Cerebral artery embolism	14.88	14.08	12	75454	2100	110511733
Orthostatic hypotension	14.80	14.08	14	75452	66235	110447598
Enterobacter infection	14.74	14.08	19	75447	5792	110508041
Underdose	14.71	14.08	13	75453	63541	110450292
Pneumonia legionella	14.71	14.08	15	75451	3554	110510279
Hot flush	14.70	14.08	14	75452	66022	110447811
Acinetobacter sepsis	14.68	14.08	5	75461	141	110513692
Necrotising scleritis	14.65	14.08	6	75460	285	110513548
Skin infection	14.62	14.08	41	75425	22468	110491365
Venous thrombosis limb	14.60	14.08	18	75448	5247	110508586
X-ray abnormal	14.53	14.08	4	75462	38113	110475720
Ephelides	14.45	14.08	5	75461	148	110513685
Hypoproteinaemia	14.40	14.08	19	75447	5926	110507907
Acute lung injury	14.38	14.08	14	75452	3137	110510696
Inflammatory marker increased	14.34	14.08	31	75435	14438	110499395
Chorioretinitis	14.34	14.08	10	75456	1405	110512428
COVID-19	14.34	14.08	103	75363	244957	110268876
Blood pressure fluctuation	14.30	14.08	18	75448	74806	110439027
Cataract	14.29	14.08	20	75446	79465	110434368
Traumatic haemothorax	14.29	14.08	8	75458	764	110513069
Limb discomfort	14.29	14.08	5	75461	40849	110472984
Liver disorder	14.17	14.08	154	75312	142089	110371744
Acute myocardial infarction	14.17	14.08	22	75444	83755	110430078
Incorrect dose administered	14.17	14.08	31	75435	103610	110410223
Urinary retention	14.13	14.08	16	75450	69667	110444166
Neuroleptic malignant syndrome	14.10	14.08	3	75463	34056	110479777

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatotoxicity	96.10	82.62	22	94	90	113747

Pharmacologic Action:

Source	Code	Description
ATC	J02AC03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOTICS FOR SYSTEMIC USE ANTIMYCOTICS FOR SYSTEMIC USE Triazole and tetrazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
FDA MoA	N0000182140	Cytochrome P450 2C19 Inhibitors
FDA MoA	N0000182141	Cytochrome P450 3A4 Inhibitors
FDA MoA	N0000185504	Cytochrome P450 2C9 Inhibitors
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50183	P450 inhibitor
CHEBI has role	CHEBI:64946	anti-HIV agent
CHEBI has role	CHEBI:65023	anti-asthmatic agent
CHEBI has role	CHEBI:70868	antileishmanial agent
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D058888	14-alpha Demethylase Inhibitors
MeSH PA	D065088	Steroid Synthesis Inhibitors
MeSH PA	D065607	Cytochrome P-450 Enzyme Inhibitors
MeSH PA	D065692	Cytochrome P-450 CYP3A Inhibitors

Related Drugs by ATC class:

J02AC Triazole and tetrazole derivatives 5 drugs

fluconazoleisavuconazoniumitraconazoleoteseconazoleposaconazole

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Invasive pulmonary aspergillosis	indication	3214003
Candidiasis of the esophagus	indication	20639004	DOID:13146
Fusarium infection	indication	64250002
Disseminated candidiasis	indication	70572005
Candidemia	indication	432261003
Fungal Infection due to Scedosporium Apiospermum	indication
Prophylaxis of invasive fungal infections in high risk allogeneic hematopoietic stem cell transplant (HSCT) recipients	indication
Fungal Infection due to Fusarium Solani	indication
Oropharyngeal Candidiasis	off-label use
Hypocalcemia	contraindication	5291005
Torsades de pointes	contraindication	31722008
Hypokalemia	contraindication	43339004
Cardiomyopathy	contraindication	85898001	DOID:0050700
Prolonged QT interval	contraindication	111975006
Hypomagnesemia	contraindication	190855004
Impaired renal function disorder	contraindication	197663003
Disease of liver	contraindication	235856003	DOID:409
Pregnancy, function	contraindication	289908002
Visual impairment	contraindication	397540003
Breastfeeding (mother)	contraindication	413712001
Poor metabolizer due to cytochrome p450 CYP2C19 variant	contraindication	424500005
Congenital long QT syndrome	contraindication	442917000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.93	acidic
pKa2	2.85	Basic
pKa3	1.42	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	4.85		CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	4.82		CHEMBL
Cholesterol 24-hydroxylase	Enzyme	Q9Y6A2	CP46A_HUMAN		Ki	7.96		CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	4.89		CHEMBL
Lanosterol 14-alpha demethylase	Enzyme		CP51_CANAL	INHIBITOR	MIC	8.73		WOMBAT-PK	CHEMBL
Lanosterol 14-alpha demethylase	Enzyme		CP51_MYCTU		MIC	5.84		WOMBAT-PK
14-alpha sterol demethylase Cyp51A	Enzyme		Q4WNT5_ASPFU		Kd	5.44		CHEMBL
14-alpha sterol demethylase	Enzyme		Q96W81_ASPFM		Kd	6.37		CHEMBL
Cytochrome P450 11A1	Enzyme		CP11A_BOVIN		Kd	5.32		CHEMBL
Sterol 14-alpha-demethylase	Enzyme		A0A2P2HJL8_ASPFA		Kd	7.25		CHEMBL
14-alpha sterol demethylase	Enzyme		G4WW85_ASPNG		Kd	7.25		CHEMBL
14-alpha sterol demethylase	Enzyme		Q9P8R0_ASPFM		Kd	7.25		CHEMBL

External reference:

ID	Source
4021347	VUID
N0000148767	NUI
D00578	KEGG_DRUG
4021347	VANDF
C0393080	UMLSCUI
CHEBI:10023	CHEBI
VOR	PDB_CHEM_ID
CHEMBL638	ChEMBL_ID
DB00582	DRUGBANK_ID
D065819	MESH_DESCRIPTOR_UI
71616	PUBCHEM_CID
7269	INN_ID
JFU09I87TR	UNII
121243	RXNORM
16711	MMSL
179944	MMSL
43734	MMSL
d04803	MMSL
009650	NDDF
385469007	SNOMEDCT_US
386116008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-3160	POWDER, FOR SUSPENSION	40 mg	ORAL	NDA	34 sections
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-3170	TABLET, FILM COATED	50 mg	ORAL	NDA	34 sections
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-3180	TABLET, FILM COATED	200 mg	ORAL	NDA	34 sections
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-3190	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	NDA	34 sections
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-3190	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	NDA	34 sections
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-3190	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	NDA	34 sections
VFEND	HUMAN PRESCRIPTION DRUG LABEL	1	0049-4190	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	NDA	33 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0121-1091	INJECTION	10 mg	INTRAVENOUS	ANDA	30 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1626	TABLET, FILM COATED	50 mg	ORAL	ANDA	31 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1640	TABLET, FILM COATED	200 mg	ORAL	ANDA	31 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-3416	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	ANDA	30 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5667	TABLET, FILM COATED	50 mg	ORAL	ANDA	30 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0781-5668	TABLET, FILM COATED	200 mg	ORAL	ANDA	30 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6596	TABLET, FILM COATED	50 mg	ORAL	ANDA	28 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7024	TABLET, FILM COATED	200 mg	ORAL	ANDA	28 sections
VORICONAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	14335-730	INJECTION, SOLUTION	10 mg	INTRAVENOUS	ANDA	31 sections
Voriconazole	Human Prescription Drug Label	1	16714-198	TABLET, FILM COATED	50 mg	ORAL	ANDA	28 sections
Voriconazole	Human Prescription Drug Label	1	16714-199	TABLET, FILM COATED	200 mg	ORAL	ANDA	28 sections
Voriconazole	Human Prescription Drug Label	1	27241-062	TABLET, FILM COATED	50 mg	ORAL	ANDA	27 sections
Voriconazole	Human Prescription Drug Label	1	27241-063	TABLET, FILM COATED	200 mg	ORAL	ANDA	27 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	31722-224	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	ANDA	28 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	31722-266	POWDER, FOR SUSPENSION	40 mg	ORAL	ANDA	29 sections
VORICONAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	40032-038	SUSPENSION	40 mg	ORAL	ANDA	29 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	40032-088	TABLET, FILM COATED	50 mg	ORAL	ANDA	28 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	40032-089	TABLET, FILM COATED	200 mg	ORAL	ANDA	28 sections
VORICONAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	43386-038	POWDER, FOR SUSPENSION	40 mg	ORAL	ANDA	29 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	43386-088	TABLET, FILM COATED	50 mg	ORAL	ANDA	29 sections
voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	43386-089	TABLET, FILM COATED	200 mg	ORAL	ANDA	29 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	43547-377	TABLET, COATED	50 mg	ORAL	ANDA	18 sections
Voriconazole	HUMAN PRESCRIPTION DRUG LABEL	1	43547-378	TABLET, COATED	200 mg	ORAL	ANDA	18 sections