norfloxacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 1967 | 70458-96-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.80 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.75 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 29 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 35.79 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 35 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.88 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 6.96 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 4.45 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 31, 1986 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| International normalised ratio fluctuation | 335.06 | 27.27 | 61 | 2076 | 2282 | 53344647 |
| Bloody discharge | 208.33 | 27.27 | 37 | 2100 | 1194 | 53345735 |
| Lyme disease | 167.98 | 27.27 | 35 | 2102 | 2642 | 53344287 |
| Therapeutic product effect incomplete | 103.59 | 27.27 | 57 | 2080 | 91727 | 53255202 |
| Infection | 93.08 | 27.27 | 67 | 2070 | 172138 | 53174791 |
| Drug intolerance | 72.11 | 27.27 | 62 | 2075 | 205431 | 53141498 |
| Drug hypersensitivity | 67.76 | 27.27 | 67 | 2070 | 265175 | 53081754 |
| Pyramidal tract syndrome | 55.43 | 27.27 | 10 | 2127 | 351 | 53346578 |
| Bradypnoea | 33.43 | 27.27 | 10 | 2127 | 3287 | 53343642 |
| Bundle branch block right | 33.01 | 27.27 | 11 | 2126 | 5122 | 53341807 |
| Eosinophils urine present | 29.69 | 27.27 | 4 | 2133 | 18 | 53346911 |
| Drug interaction | 29.65 | 27.27 | 40 | 2097 | 219289 | 53127640 |
| Tendonitis | 29.04 | 27.27 | 14 | 2123 | 16992 | 53329937 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic encephalopathy | 45.75 | 23.58 | 18 | 1163 | 14877 | 32497468 |
| Hydrocholecystis | 38.97 | 23.58 | 7 | 1174 | 265 | 32512080 |
| Obsessive-compulsive disorder | 30.44 | 23.58 | 10 | 1171 | 4924 | 32507421 |
| Tendon rupture | 30.29 | 23.58 | 11 | 1170 | 7292 | 32505053 |
| Tendonitis | 28.37 | 23.58 | 11 | 1170 | 8724 | 32503621 |
| Intracranial aneurysm | 28.18 | 23.58 | 7 | 1174 | 1271 | 32511074 |
| Mania | 27.33 | 23.58 | 11 | 1170 | 9621 | 32502724 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01MA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
| ATC | J01RA13 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
| ATC | J01RA14 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE COMBINATIONS OF ANTIBACTERIALS Combinations of antibacterials |
| ATC | S01AE02 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones |
| FDA CS | M0023650 | Quinolones |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D065609 | Cytochrome P-450 CYP1A2 Inhibitors |
| MeSH PA | D065607 | Cytochrome P-450 Enzyme Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
| MeSH PA | D059005 | Topoisomerase II Inhibitors |
| FDA EPC | N0000175937 | Quinolone Antimicrobial |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Otitis externa | indication | 3135009 | |
| Typhoid fever | indication | 4834000 | DOID:13258 |
| Septicemia due to Escherichia coli | indication | 9323009 | |
| Prostatitis | indication | 9713002 | DOID:14654 |
| Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
| Gonorrhea | indication | 15628003 | DOID:7551 |
| Enteric campylobacteriosis | indication | 18081009 | |
| Infectious diarrheal disease | indication | 19213003 | DOID:13250 |
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
| Staphylococcal pneumonia | indication | 22754005 | |
| Acute gonococcal urethritis | indication | 29864006 | |
| Acute bacterial peritonitis | indication | 31860008 | |
| Bronchitis | indication | 32398004 | DOID:6132 |
| Postoperative infection | indication | 33910007 | |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Shigellosis | indication | 36188001 | |
| Cystitis | indication | 38822007 | DOID:1679 |
| Pneumonia due to Pseudomonas | indication | 41381004 | |
| Gonorrhea of rectum | indication | 42746002 | |
| Pyelonephritis | indication | 45816000 | DOID:11400 |
| Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
| Peritonitis | indication | 48661000 | |
| Lower respiratory tract infection | indication | 50417007 | |
| Pneumonia due to Escherichia coli | indication | 51530003 | |
| Bacterial pneumonia | indication | 53084003 | DOID:874 |
| Klebsiella cystitis | indication | 60867007 | |
| Pneumonia due to Klebsiella pneumoniae | indication | 64479007 | |
| Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
| Miscarriage with sepsis | indication | 67465009 | |
| Acute maxillary sinusitis | indication | 68272006 | DOID:2050 |
| Urinary tract infectious disease | indication | 68566005 | |
| Haemophilus influenzae pneumonia | indication | 70036007 | |
| Infection due to Escherichia coli | indication | 71057007 | |
| Rhinoscleroma | indication | 72409005 | DOID:11336 |
| Abdominal abscess | indication | 75100008 | |
| Acute bacterial sinusitis | indication | 75498004 | |
| Nongonococcal urethritis | indication | 84619001 | |
| Infective otitis externa | indication | 86981007 | DOID:9463 |
| Chronic tubotympanic suppurative otitis media | indication | 87665008 | DOID:14435 |
| Endomyometritis | indication | 88027004 | |
| Infection of bone | indication | 111253001 | |
| Female genital tract infection | indication | 125585007 | |
| Infectious disease of abdomen | indication | 128070006 | |
| Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
| Infection due to Enterobacteriaceae | indication | 128945009 | |
| Postnatal infection | indication | 178280004 | |
| Urethritis due to Chlamydia trachomatis | indication | 179101003 | |
| Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
| Chlamydial pelvic inflammatory disease | indication | 188463006 | |
| Acute Moraxella catarrhalis bronchitis | indication | 195722003 | |
| Proteus pneumonia | indication | 195888009 | |
| Malignant otitis externa due to Pseudomonas aeruginosa | indication | 232230009 | |
| Acute bacterial bronchitis | indication | 233598009 | |
| Pneumonia | indication | 233604007 | DOID:552 |
| Pneumococcal pneumonia | indication | 233607000 | |
| Chlamydial pneumonia | indication | 233609002 | |
| Infective cystitis | indication | 236620008 | |
| Chancroid | indication | 266143009 | DOID:13778 |
| Female pelvic cellulitis | indication | 280486004 | |
| Escherichia coli urinary tract infection | indication | 301011002 | |
| Proteus urinary tract infection | indication | 301012009 | |
| Streptococcus pyogenes infection | indication | 302809008 | |
| Bacterial urinary infection | indication | 312124009 | |
| Infective otitis media | indication | 312218008 | |
| Infectious disorder of joint | indication | 363162000 | |
| Infection due to Staphylococcus aureus | indication | 406602003 | |
| Anthrax | indication | 409498004 | DOID:7427 |
| Acute osteomyelitis | indication | 409780002 | |
| Nosocomial pneumonia | indication | 425464007 | |
| Acute exacerbation of chronic bronchitis | indication | 425748003 | |
| Urinary tract infection caused by Klebsiella | indication | 369001000119100 | |
| Enterococcus Urinary Tract Infection | indication | ||
| Klebsiella Pneumoniae Chronic Bronchitis | indication | ||
| Pseudomonas Aeruginosa Cystitis | indication | ||
| Haemophilus Parainfluenzae Chronic Bronchitis | indication | ||
| Complicated Urinary Tract Infections | indication | ||
| Prevotella Postpartum Infection | indication | ||
| Complicated Bacterial Peritonitis | indication | ||
| E. Coli Cystitis | indication | ||
| Complicated Skin and Skin Structure Streptococcus Pyogenes Infection | indication | ||
| Bacterial Corneal Ulcer Infection | indication | ||
| Enterobacter Osteomyelitis | indication | ||
| Staphylococcus Cystitis | indication | ||
| Citrobacter Urinary Tract Infection | indication | ||
| Gardnerella Septic Abortion | indication | ||
| Enterobacter Pneumonia | indication | ||
| Providencia Urinary Tract Infection | indication | ||
| Complicated Skin and Skin Structure Staphylococcus Aureus Infection | indication | ||
| Chlamydia Pneumoniae Bronchitis | indication | ||
| Morganella Morganii Urinary Tract Infection | indication | ||
| Skin and Skin Structure Morganella Morganii Infection | indication | ||
| Complicated Klebsiella Peritonitis | indication | ||
| Bacteroides Pelvic Cellulitis | indication | ||
| Moraxella Catarrhalis Chronic Bronchitis | indication | ||
| Haemophilus Influenzae Chronic Bronchitis | indication | ||
| Staphylococcus Epidermidis Urinary Tract Infection | indication | ||
| Legionella Pneumophila Pneumonia | indication | ||
| EnterobacterJoint Infection | indication | ||
| E. Coli Endomyometritis | indication | ||
| Streptococcal Pelvic Cellulitis | indication | ||
| Bacteroides Endomyometritis | indication | ||
| Chronic Enterococcus faecalis Prostatitis | indication | ||
| Gardnerella Endomyometritis | indication | ||
| Pseudomonas Aeruginosa Osteomyelitis | indication | ||
| Nosocomial Pneumonia due to Methicillin-Sensitive Staphylococcus Aureus | indication | ||
| Enterococcus Pelvic Cellulitis | indication | ||
| Serratia Joint Infection | indication | ||
| Proteus Prostatitis | indication | ||
| Complicated E. Coli Peritonitis | indication | ||
| Skin and Skin Structure Citrobacter Infection | indication | ||
| Skin and Skin Structure Proteus Infection | indication | ||
| Serratia Urinary Tract Infection | indication | ||
| Pseudomonas Aeruginosa Urinary Tract Infection | indication | ||
| Gardnerella Postpartum Infection | indication | ||
| Enterococcus Postpartum Infection | indication | ||
| Bacteroides Septic Abortion | indication | ||
| Prevotella Septic Abortion | indication | ||
| Skin and Skin Structure Providencia Infection | indication | ||
| Prevention of Infection in Transrectal Prostate Biopsy | indication | ||
| Chronic Escherichia coli Prostatitis | indication | ||
| Gardnerella Pelvic Cellulitis | indication | ||
| Complicated Skin and Skin Structure Streptococcus Agalactiae Infection | indication | ||
| Enterococcus Complicated UTI | indication | ||
| Prevotella Pelvic Cellulitis | indication | ||
| Diarrhea due to E. Coli | indication | ||
| Complicated Proteus UTI | indication | ||
| Streptococcal Endomyometritis | indication | ||
| Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
| E. Coli Septic Abortion | indication | ||
| Haemophilus Influenzae Bronchitis | indication | ||
| Complicated Streptococcus Peritonitis | indication | ||
| Complicated Skin and Skin Structure Infection | indication | ||
| Nosocomial Pneumonia due to Escherichia Coli | indication | ||
| E. Coli Pyelonephritis | indication | ||
| Vaginal Hysterectomy Infection Prevention | indication | ||
| Peptostreptococcus Postpartum Infection | indication | ||
| Enterobacter Cloacae Bronchitis | indication | ||
| Mixed Gonococcal and Chlamydia Infection of the Urethra | indication | ||
| Peptostreptococcus Endomyometritis | indication | ||
| Gram-Negative Aerobic Bacillary Pneumonia | indication | ||
| Citrobacter Complicated UTI | indication | ||
| Colorectal Surgery Infection Prevention | indication | ||
| Enterococcus Endomyometritis | indication | ||
| Klebsiella Nosocomial Pneumonia | indication | ||
| Chlamydia Cervicitis | indication | ||
| Chronic Staphylococcus epidermidis Prostatitis | indication | ||
| Mixed Gonococcal and Chlamydia Infection of the Cervix | indication | ||
| Nosocomial Pneumonia due to Serratia Marcescens | indication | ||
| Skin and Skin Structure Streptococcus Infection | indication | ||
| Nosocomial Pneumonia due to Streptococcus Pneumoniae | indication | ||
| Synergy for Nosocomial Pneumonia due to Pseudomonas Aeruginosa | indication | ||
| Streptococcal Septic Abortion | indication | ||
| Prevotella Endomyometritis | indication | ||
| Staphylococcus Aureus Otitis Externa | indication | ||
| Proteus Cystitis | indication | ||
| Skin and Skin Structure Serratia Infection | indication | ||
| Complicated Skin and Skin Structure Proteus Infection | indication | ||
| Peptostreptococcus Septic Abortion | indication | ||
| Pseudomonas Aeruginosa Joint Infection | indication | ||
| Moraxella Catarrhalis Pneumonia | indication | ||
| Complicated Skin and Skin Structure Enterococcus Faecalis Infection | indication | ||
| Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
| Citrobacter Cystitis | indication | ||
| Serratia Osteomyelitis | indication | ||
| E. Coli Postpartum Infection | indication | ||
| Prevention of Infection from Transurethral Surgery | indication | ||
| Enterobacter Cystitis | indication | ||
| Bacteroides Postpartum Infection | indication | ||
| Staphylococcus Aureus Bronchitis | indication | ||
| Complicated UTI with Pseudomonas Aeruginosa | indication | ||
| Streptococcal Postpartum Infection | indication | ||
| E. Coli Pelvic Cellulitis | indication | ||
| Complicated Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
| Haemophilus Parainfluenzae Bronchitis | indication | ||
| Nosocomial Pneumonia due to Klebsiella Pneumoniae | indication | ||
| Haemophilus Parainfluenzae Pneumonia | indication | ||
| Skin and Skin Structure Pseudomonas Aeruginosa Infection | indication | ||
| Staphylococcus Epidermidis Skin and Skin Structure Infection | indication | ||
| Complicated Skin and Skin Structure E. Coli Infection | indication | ||
| Nosocomial Pneumonia due to Haemophilus Influenzae | indication | ||
| Peptostreptococcus Pelvic Cellulitis | indication | ||
| Streptococcus Pneumoniae Bronchitis | indication | ||
| Staphylococcus Chronic Bronchitis | indication | ||
| Complicated Bacteroides Peritonitis | indication | ||
| Chronic Bacterial Prostatitis | indication | ||
| Enterococcus Septic Abortion | indication | ||
| Staphylococcus Saprophyticus Urinary Tract Infection | indication | ||
| Inhalational anthrax | off-label use | 11389007 | |
| Traveler's diarrhea | off-label use | 11840006 | |
| Acute tuberculosis | off-label use | 25629007 | |
| Salmonella septicemia | off-label use | 49786009 | |
| Cutaneous anthrax | off-label use | 84980006 | DOID:7426 |
| Gastrointestinal anthrax | off-label use | 111798006 | DOID:13386 |
| Pulmonary tuberculosis | off-label use | 154283005 | DOID:2957 |
| Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
| Bacterial gastroenteritis | off-label use | 274080003 | |
| Ventilator-acquired pneumonia | off-label use | 429271009 | |
| Prevention of Meningococcal Meningitis | off-label use | ||
| Diabetic Foot Infection | off-label use | ||
| Hallucinations | contraindication | 7011001 | |
| Achilles tendinitis | contraindication | 11654001 | |
| Agranulocytosis | contraindication | 17182001 | DOID:12987 |
| Lowered convulsive threshold | contraindication | 19260006 | |
| Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
| Torsades de pointes | contraindication | 31722008 | |
| Transplantation of heart | contraindication | 32413006 | |
| Dehydration | contraindication | 34095006 | |
| Tendinitis | contraindication | 34840004 | DOID:971 |
| Depressive disorder | contraindication | 35489007 | |
| Hypokalemia | contraindication | 43339004 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Bradycardia | contraindication | 48867003 | |
| Acute nephropathy | contraindication | 58574008 | |
| Hepatic failure | contraindication | 59927004 | |
| Psychotic disorder | contraindication | 69322001 | |
| Transplant of kidney | contraindication | 70536003 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Transplant of lung | contraindication | 88039007 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Prolonged QT interval | contraindication | 111975006 | |
| Pancytopenia | contraindication | 127034005 | DOID:12450 |
| Liver function tests abnormal | contraindication | 166603001 | |
| Hypomagnesemia | contraindication | 190855004 | |
| Superimposed infection | contraindication | 193198003 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Drug-induced hepatitis | contraindication | 235876009 | |
| Rhabdomyolysis | contraindication | 240131006 | |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Peripheral nerve disease | contraindication | 302226006 | |
| Viral ear infection | contraindication | 312137007 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Traumatic rupture of tendon | contraindication | 415749005 | |
| Congenital long QT syndrome | contraindication | 442917000 | |
| Shoulder Tendonitis | contraindication | ||
| Tremors | contraindication | ||
| Severe Cerebral Arteriosclerosis | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.98 | acidic |
| pKa2 | 8.54 | Basic |
| pKa3 | 1.37 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-3 | Ion channel | IC50 | 6.29 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-5 | Ion channel | IC50 | 6.29 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-4 | Ion channel | IC50 | 6.29 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-6 | Ion channel | IC50 | 6.29 | WOMBAT-PK | |||||
| DNA topoisomerase 2-beta | Enzyme | IC50 | 6.22 | WOMBAT-PK | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 4.75 | CHEMBL | |||||
| Gamma-aminobutyric acid receptor subunit alpha-1 | Ion channel | IC50 | 6.29 | WOMBAT-PK | |||||
| Gamma-aminobutyric acid receptor subunit alpha-2 | Ion channel | IC50 | 6.29 | WOMBAT-PK | |||||
| DNA topoisomerase 4 subunit A | Enzyme | INHIBITOR | IC50 | 5.29 | WOMBAT-PK | CHEMBL | |||
| DNA gyrase subunit A | Enzyme | INHIBITOR | IC50 | 6.05 | WOMBAT-PK | CHEMBL | |||
| DNA topoisomerase 4 subunit A | Enzyme | IC50 | 5.46 | CHEMBL | |||||
| DNA gyrase subunit A | Enzyme | IC50 | 4.28 | CHEMBL | |||||
| GABA-A receptor; anion channel | Ion channel | IC50 | 7.70 | CHEMBL | |||||
| Multidrug resistance protein mdtK | Unclassified | Kd | 4.01 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019503 | VUID |
| N0000147623 | NUI |
| D00210 | KEGG_DRUG |
| 4019503 | VANDF |
| CHEBI:100246 | CHEBI |
| CHEMBL9 | ChEMBL_ID |
| CHEMBL33 | ChEMBL_ID |
| 5105 | INN_ID |
| DB01059 | DRUGBANK_ID |
| N0F8P22L1P | UNII |
| 4539 | PUBCHEM_CID |
| 7517 | RXNORM |
| 5189 | MMSL |
| d00113 | MMSL |
| 002881 | NDDF |
| 387271008 | SNOMEDCT_US |
| 49485009 | SNOMEDCT_US |
| D009643 | MESH_DESCRIPTOR_UI |
| C0028365 | UMLSCUI |
Pharmaceutical products:
None