AI ASSISTANT
Ask DrugCentral
Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
AI can make mistakes. Verify answers against the original sources before relying on them.
bifonazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| systemic antifungal agents, miconazole derivatives | 370 | 60628-96-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 4.745 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.403 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 16.406 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 19.275 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 0.090 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 0.550 | % | High | 1 |
| herg | hERG pIC50 | 5.532 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 20.606 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 40.832 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 0.160 | % | High | 1 |
| kinase-safety-class | ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,TEK,TGFBR1 | 30 | |||
| kinase-selectivity-class | MAP2K6 | 1 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.630 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 61.376 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| mppb | Mouse plasma protein binding (% unbound) | 0.140 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.297 | High | 1 | |
| pppb | Pig plasma protein binding (% unbound) | 0.470 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 56.364 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 1.510 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 0.160 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 1.297 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AC10 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| ATC | D01AC60 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
Related Drugs by ATC class:
D01AC Imidazole and triazole derivatives 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cytochrome P450 3A4 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
| Steroid 17-alpha-hydroxylase/17,20 lyase | Enzyme | Ki | 7.25 | CHEMBL | |||||
| Lanosterol 14-alpha demethylase | Enzyme | IC50 | 6.47 | CHEMBL | |||||
| Indoleamine 2,3-dioxygenase 1 | Enzyme | IC50 | 4.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01775 | KEGG_DRUG |
| 19295 | RXNORM |
| C0053570 | UMLSCUI |
| CHEBI:31286 | CHEBI |
| TMI | PDB_CHEM_ID |
| CHEMBL277535 | ChEMBL_ID |
| DB04794 | DRUGBANK_ID |
| C036596 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2378 | PUBCHEM_CID |
| 4887 | INN_ID |
| QYJ305Z91O | UNII |
| 136216003 | SNOMEDCT_US |
| 396036005 | SNOMEDCT_US |
| 004316 | NDDF |
| QYJ305Z91O | INXIGHT DRUGS |
Pharmaceutical products:
None