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fenticonazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| systemic antifungal agents, miconazole derivatives | 1166 | 72479-26-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | V |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 4.856 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.510 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.594 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 15.488 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 0.070 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 0.100 | % | High | 1 |
| herg | hERG pIC50 | 5.334 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 15.668 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 53.703 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 0.260 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,EIF2AK3,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PRKDC,SIK2,STK33,TEK,TTK | 35 | |||
| kinase-selectivity-class | ERBB2,GRK2,PDK4 | 3 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.426 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 42.462 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 0.150 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.615 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 0.150 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 21.086 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 0.220 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 0.140 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 0.356 | uM | High | 1 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AC12 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives |
| ATC | G01AF12 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000935 | Antifungal Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
Related Drugs by ATC class:
D01AC Imidazole and triazole derivatives 20 drugs
G01AF Imidazole derivatives 16 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Candidal vulvovaginitis | indication | 72605008 | DOID:2272 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.49 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02582 | KEGG_DRUG |
| 73151-29-8 | SECONDARY_CAS_RN |
| C0060203 | UMLSCUI |
| CHEBI:82863 | CHEBI |
| CHEMBL1651990 | ChEMBL_ID |
| CHEMBL2107703 | ChEMBL_ID |
| DB13434 | DRUGBANK_ID |
| C033486 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4875 | INN_ID |
| QG05NRB077 | UNII |
| 51755 | PUBCHEM_CID |
| 236229 | RXNORM |
| 005463 | NDDF |
| 005485 | NDDF |
| 326274003 | SNOMEDCT_US |
| 396054009 | SNOMEDCT_US |
| 419234006 | SNOMEDCT_US |
Pharmaceutical products:
None