luliconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 4813 187164-19-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • luliconazole
  • luzu
  • NND-502
  • PR-2699
  • lulicon
an antifungal that belongs to the azole class, luliconazole appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase, inhibition of this enzyme’s activity by azoles results in decreased amounts of ergosterol, a constituent of fungal cell membranes, and a corresponding accumulation of lanosterol
  • Molecular weight: 354.27
  • Formula: C14H9Cl2N3S2
  • CLOGP: 3.49
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 41.61
  • ALOGS: -3.73
  • ROTB: 2

  • Status: ONP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 14, 2013 FDA MEDICIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC18 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Tinea corporis indication 84849002
Tinea cruris indication 399029005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.91 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1% LUZU BAUSCH N204153 Nov. 14, 2013 RX CREAM TOPICAL 9012484 Sept. 6, 2033 TREATMENT OF FUNGAL INFECTIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lanosterol 14-alpha demethylase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D01980 KEGG_DRUG
4033088 VUID
N0000190122 NUI
4033088 VANDF
CHEBI:34825 CHEBI
CHEMBL2105689 ChEMBL_ID
C112528 MESH_SUPPLEMENTAL_RECORD_UI
7366 IUPHAR_LIGAND_ID
8161 INN_ID
DB08933 DRUGBANK_ID
RE91AN4S8G UNII
3003141 PUBCHEM_CID
1482680 RXNORM
207437 MMSL
283910 MMSL
29867 MMSL
015304 NDDF
724031004 SNOMEDCT_US
763571006 SNOMEDCT_US
C1956280 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
LULICONAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 68682-850 CREAM 10 mg TOPICAL NDA 26 sections
Luzu HUMAN PRESCRIPTION DRUG LABEL 1 99207-850 CREAM 10 mg TOPICAL NDA 26 sections