eberconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 978 128326-82-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • eberconazole
  • ebernet
  • eberconazole nitrate
  • Molecular weight: 329.22
  • Formula: C18H14Cl2N2
  • CLOGP: 4.97
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 17.82
  • ALOGS: -5.18
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.664 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.671 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 57.280 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 8.054 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 1.900 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 4.890 % High 1
herg hERG pIC50 5.154 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 5.861 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 19.999 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 2.070 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK,TGFBR1,TTK 37
kinase-selectivity-class AXL,GRK2,MAP2K6,PIK3CB,PIK3CD 5
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.351 High 1
mh-clint Mouse hepatocyte intrinsic clearance 21.380 High 1
mppb Mouse plasma protein binding (% unbound) 2.410 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.592 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 4.010 % High 1
rh-clint Rat hepatocyte intrinsic clearance 20.137 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 20.940 % High 1
rppb Rat plasma protein binding (% unbound) 2.530 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 80.168 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC17 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives

Related Drugs by ATC class:

D01AC Imidazole and triazole derivatives 20 drugs
bifonazolechlormidazoleclotrimazoleeconazoleefinaconazolefenticonazolefluconazoleflutrimazoleisoconazoleketoconazolelanoconazoleluliconazole show all 20 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07882 KEGG_DRUG
CHEBI:82862 CHEBI
CHEMBL558722 ChEMBL_ID
C118963 MESH_SUPPLEMENTAL_RECORD_UI
DB13656 DRUGBANK_ID
V7O1U41C9B UNII
018073 NDDF
018074 NDDF
1187438001 SNOMEDCT_US
1187439009 SNOMEDCT_US
702797004 SNOMEDCT_US
C0767000 UMLSCUI
6680 INN_ID
72051 PUBCHEM_CID
130104-32-4 SECONDARY_CAS_RN

Pharmaceutical products:

None