finasteride ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
testosterone reductase inhibitors 1171 98319-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • finasteride
  • finastid
  • prosteride
  • prostide
  • propecia
An orally active 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE inhibitor. It is used as a surgical alternative for treatment of benign PROSTATIC HYPERPLASIA.
  • Molecular weight: 372.55
  • Formula: C23H36N2O2
  • CLOGP: 3.01
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.20
  • ALOGS: -5.27
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mg O
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.19 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 63 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.10 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAP3K7,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,STK33,TEK 23
kinase-selectivity-class GRK2 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.038 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
rat-kpuu-brain Rat brain Kpuu 0.678 % High 1

Approvals:

DateAgencyCompanyOrphan
June 19, 1992 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Exposure via body fluid 320.00 22.93 45 1940 579 90625883
Exposure during pregnancy 97.45 22.93 62 1923 238348 90388114
Abortion spontaneous 81.61 22.93 34 1951 54022 90572440
Product administration error 62.40 22.93 23 1962 26400 90600062
Abortion induced 54.37 22.93 17 1968 11871 90614591
Paternal drugs affecting foetus 53.44 22.93 7 1978 50 90626412
Exposure via father 48.91 22.93 8 1977 290 90626172
Trans-sexualism 36.68 22.93 4 1981 3 90626459
Hypertrichosis 36.12 22.93 8 1977 1471 90624991
Ophthalmoplegia 34.79 22.93 8 1977 1741 90624721
Endometrial cancer 33.71 22.93 9 1976 3603 90622859
Temporal lobe epilepsy 32.83 22.93 6 1979 419 90626043
Hidradenitis 32.06 22.93 9 1976 4338 90622124
White matter lesion 31.88 22.93 8 1977 2513 90623949
Skin induration 29.83 22.93 8 1977 3254 90623208
Skin plaque 28.48 22.93 10 1975 9965 90616497
Nystagmus 27.54 22.93 9 1976 7218 90619244
No adverse event 25.95 22.93 17 1968 67965 90558497
Myasthenia gravis 24.01 22.93 8 1977 6817 90619645

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sexual dysfunction 3007.74 10.96 952 94543 5823 42520017
Erectile dysfunction 2602.94 10.96 1219 94276 23694 42502146
Libido decreased 1605.49 10.96 553 94942 4545 42521295
Loss of libido 1464.44 10.96 456 95039 2614 42523226
Semen volume decreased 1007.38 10.96 218 95277 136 42525704
Ejaculation disorder 933.66 10.96 253 95242 795 42525045
Depression 896.58 10.96 1173 94322 110190 42415650
Cognitive disorder 676.40 10.96 582 94913 33590 42492250
Ejaculation failure 583.93 10.96 167 95328 674 42525166
Anxiety 580.81 10.96 990 94505 117570 42408270
Testicular pain 571.39 10.96 230 95265 3024 42522816
Penile size reduced 570.98 10.96 125 95370 89 42525751
Post 5-alpha-reductase inhibitor syndrome 520.17 10.96 109 95386 43 42525797
Organic erectile dysfunction 466.30 10.96 110 95385 152 42525688
Gynaecomastia 445.46 10.96 303 95192 12264 42513576
Hypogonadism 430.67 10.96 173 95322 2261 42523579
Blood testosterone decreased 368.49 10.96 192 95303 4710 42521130
Hormone level abnormal 349.84 10.96 99 95396 381 42525459
Testicular atrophy 293.46 10.96 92 95403 540 42525300
Penis injury 275.71 10.96 72 95423 187 42525653
Suicidal ideation 274.32 10.96 431 95064 47730 42478110
Varicocele 267.30 10.96 60 95435 55 42525785
Off label use 263.74 10.96 659 94836 637676 41888164
Genital hypoaesthesia 251.21 10.96 66 95429 177 42525663
Penis disorder 216.59 10.96 91 95404 1342 42524498
Male orgasmic disorder 208.35 10.96 50 95445 78 42525762
Painful ejaculation 201.39 10.96 52 95443 127 42525713
Orgasm abnormal 196.13 10.96 49 95446 99 42525741
Testicular failure 191.78 10.96 42 95453 30 42525810
Infertility male 178.75 10.96 48 95447 144 42525696
Testicular disorder 173.04 10.96 69 95426 883 42524957
Semen analysis abnormal 168.86 10.96 34 95461 5 42525835
Pyrexia 165.83 10.96 402 95093 393640 42132200
Hypogonadism male 162.97 10.96 52 95443 326 42525514
Benign prostatic hyperplasia 159.98 10.96 216 95279 20836 42505004
Toxicity to various agents 158.35 10.96 168 95327 228968 42296872
Drug ineffective 156.60 10.96 805 94690 629392 41896448
Androgen deficiency 154.58 10.96 45 95450 196 42525644
Epididymal cyst 154.26 10.96 34 95461 26 42525814
Endocrine disorder 151.21 10.96 49 95446 325 42525515
Male reproductive tract disorder 150.42 10.96 42 95453 152 42525688
Panic attack 145.12 10.96 150 95345 10895 42514945
Hair transplant 143.04 10.96 30 95465 12 42525828
Prostatitis 141.24 10.96 115 95380 6133 42519707
Product administration error 131.52 10.96 183 95312 18160 42507680
Genital paraesthesia 126.71 10.96 28 95467 22 42525818
Febrile neutropenia 118.61 10.96 145 95350 185558 42340282
Muscle atrophy 114.29 10.96 116 95379 8245 42517595
Gastrooesophageal reflux disease 112.05 10.96 285 95210 44738 42481102
Urine flow decreased 108.82 10.96 56 95439 1337 42524503
Right atrial hypertrophy 108.71 10.96 46 95449 691 42525149
Sperm concentration decreased 108.21 10.96 33 95462 174 42525666
Reproductive tract disorder 107.17 10.96 21 95474 0 42525840
Dizziness 104.52 10.96 932 94563 248322 42277518
Anorgasmia 104.39 10.96 51 95444 1086 42524754
Multiple organ dysfunction syndrome 101.69 10.96 45 95450 96990 42428850
Penile curvature 101.45 10.96 28 95467 96 42525744
Infertility 100.37 10.96 32 95463 200 42525640
Orgasmic sensation decreased 96.89 10.96 24 95471 46 42525794
Depressed mood 95.87 10.96 181 95314 23203 42502637
Premature ejaculation 95.79 10.96 27 95468 102 42525738
Breast mass 94.55 10.96 42 95453 714 42525126
Wrong technique in product usage process 93.01 10.96 257 95238 42378 42483462
Urinary retention 92.62 10.96 255 95240 41959 42483881
Semen viscosity decreased 91.86 10.96 18 95477 0 42525840
Male genital atrophy 91.76 10.96 19 95476 6 42525834
Drug abuse 90.36 10.96 62 95433 104709 42421131
Vomiting 88.47 10.96 342 95153 289381 42236459
Major depression 87.07 10.96 82 95413 5316 42520524
Breast enlargement 85.41 10.96 34 95461 433 42525407
Insomnia 84.69 10.96 503 94992 117750 42408090
Disturbance in sexual arousal 84.49 10.96 26 95469 142 42525698
Breast tenderness 84.01 10.96 40 95455 803 42525037
Brain injury 83.10 10.96 94 95401 7561 42518279
Disturbance in attention 82.72 10.96 197 95298 29669 42496171
Condition aggravated 81.40 10.96 305 95190 260449 42265391
Vasectomy 81.20 10.96 20 95475 37 42525803
Male sexual dysfunction 80.36 10.96 31 95464 361 42525479
Penile pain 80.23 10.96 50 95445 1738 42524102
Foetal exposure during pregnancy 80.03 10.96 7 95488 47304 42478536
Bronchial secretion retention 79.94 10.96 48 95447 1559 42524281
Interstitial lung disease 79.69 10.96 38 95457 78424 42447416
Prostatic pain 79.38 10.96 30 95465 329 42525511
Right ventricular hypertrophy 78.87 10.96 47 95448 1505 42524335
Fall 77.71 10.96 835 94660 233685 42292155
Sleep apnoea syndrome 77.36 10.96 158 95337 21450 42504390
Fatigue 75.89 10.96 1383 94112 434258 42091582
Dysuria 74.42 10.96 194 95301 30902 42494938
Bronchial wall thickening 73.88 10.96 43 95452 1317 42524523
Testicular cyst 71.77 10.96 19 95476 53 42525787
Breast cancer 71.28 10.96 27 95468 298 42525542
Tonsillectomy 70.99 10.96 30 95465 449 42525391
Haematospermia 70.10 10.96 27 95468 313 42525527
Intervertebral disc degeneration 69.21 10.96 84 95411 7283 42518557
Adverse event 68.81 10.96 159 95336 23481 42502359
Obstruction 67.80 10.96 56 95439 3047 42522793
Generalised anxiety disorder 65.69 10.96 35 95460 899 42524941
Aortic valve stenosis 64.75 10.96 54 95441 2978 42522862
Pollakiuria 64.00 10.96 150 95345 22355 42503485
Genital atrophy 63.65 10.96 13 95482 3 42525837
Amnesia 63.58 10.96 173 95322 28264 42497576
Breast pain 62.57 10.96 41 95454 1556 42524284
Haematuria 60.21 10.96 273 95222 57526 42468314
Mucosal inflammation 59.99 10.96 18 95477 49356 42476484
Septic shock 59.07 10.96 71 95424 91601 42434239
IVth nerve paralysis 58.77 10.96 28 95467 563 42525277
Spermatocele 57.89 10.96 14 95481 23 42525817
Somatic symptom disorder 57.22 10.96 30 95465 745 42525095
Treatment failure 56.77 10.96 35 95460 62589 42463251
Product use in unapproved indication 56.69 10.96 217 95278 184239 42341601
Blood oestrogen increased 56.62 10.96 15 95480 42 42525798
Dihydrotestosterone decreased 56.14 10.96 11 95484 0 42525840
Prostatomegaly 55.71 10.96 69 95426 6108 42519732
Dark circles under eyes 54.72 10.96 16 95479 71 42525769
Libido disorder 54.69 10.96 23 95472 340 42525500
Cytokine release syndrome 54.52 10.96 16 95479 44511 42481329
Neutropenia 54.22 10.96 246 95249 199185 42326655
Nocturia 53.72 10.96 97 95398 12015 42513825
Pulmonary function test abnormal 53.47 10.96 46 95449 2648 42523192
Melanocytic naevus 53.20 10.96 48 95447 2944 42522896
Spermatozoa abnormal 51.41 10.96 14 95481 45 42525795
Oligospermia 51.31 10.96 16 95479 92 42525748
Orthostatic hypotension 51.28 10.96 168 95327 30402 42495438
Hormone receptor positive breast cancer 50.86 10.96 13 95482 30 42525810
Marital problem 50.72 10.96 14 95481 48 42525792
Drug ineffective for unapproved indication 50.60 10.96 20 95475 46143 42479697
C-reactive protein increased 50.41 10.96 41 95454 63519 42462321
Azoospermia 49.17 10.96 24 95471 510 42525330
Disease progression 48.10 10.96 163 95332 143493 42382347
Intentional product use issue 48.03 10.96 54 95441 71779 42454061
Intentional overdose 47.70 10.96 28 95467 51428 42474412
Breast cancer male 47.35 10.96 22 95473 417 42525423
Hypospermia 46.71 10.96 11 95484 15 42525825
Nausea 46.33 10.96 619 94876 396180 42129660
Apathy 46.11 10.96 74 95421 8332 42517508
Scrotal disorder 45.73 10.96 16 95479 138 42525702
Sepsis 45.59 10.96 261 95234 199073 42326767
Hypoacusis 45.07 10.96 117 95378 18585 42507255
Lower urinary tract symptoms 45.06 10.96 21 95474 401 42525439
Epididymitis 44.98 10.96 44 95451 2990 42522850
Genital burning sensation 44.78 10.96 11 95484 20 42525820
Prostatic disorder 44.71 10.96 48 95447 3641 42522199
Ascites 44.40 10.96 37 95458 56641 42469199
Overdose 44.37 10.96 107 95388 105157 42420683
Hyperlipidaemia 44.26 10.96 127 95368 21389 42504451
Self esteem decreased 43.73 10.96 22 95473 500 42525340
Hepatic vein dilatation 42.88 10.96 17 95478 214 42525626
Patellofemoral pain syndrome 42.31 10.96 15 95480 135 42525705
Soft tissue injury 42.25 10.96 17 95478 223 42525617
Malignant neoplasm progression 41.99 10.96 115 95380 108285 42417555
Skin atrophy 41.96 10.96 39 95456 2486 42523354
Cardiac arrest 41.58 10.96 117 95378 109203 42416637
Mood altered 41.51 10.96 81 95414 10637 42515203
Arthroscopy 41.37 10.96 15 95480 145 42525695
Leukopenia 41.01 10.96 65 95430 74681 42451159
Knee operation 40.88 10.96 39 95456 2569 42523271
Terminal dribbling 40.83 10.96 8 95487 0 42525840
Teratospermia 40.83 10.96 8 95487 0 42525840
Androgens abnormal 40.83 10.96 8 95487 0 42525840
Cytomegalovirus infection 40.68 10.96 11 95484 32295 42493545
Partner stress 40.40 10.96 14 95481 117 42525723
Anhedonia 40.20 10.96 66 95429 7574 42518266
Dehydroepiandrosterone decreased 40.09 10.96 10 95485 20 42525820
Tachycardia 39.33 10.96 107 95388 100980 42424860
Metabolic acidosis 39.23 10.96 35 95460 51823 42474017
Attention deficit hyperactivity disorder 38.66 10.96 41 95454 3067 42522773
Mixed anxiety and depressive disorder 38.64 10.96 16 95479 227 42525613
Chest X-ray abnormal 38.49 10.96 49 95446 4459 42521381
Radical prostatectomy 38.14 10.96 11 95484 46 42525794
Ejaculation delayed 38.11 10.96 17 95478 292 42525548
Diastolic dysfunction 37.66 10.96 61 95434 6922 42518918
Wisdom teeth removal 37.41 10.96 16 95479 247 42525593
Feeling abnormal 37.27 10.96 276 95219 69510 42456330
Emotional distress 37.07 10.96 99 95396 15994 42509846
Anogenital warts 36.68 10.96 22 95473 713 42525127
Hernia repair 36.38 10.96 28 95467 1375 42524465
Pudendal canal syndrome 36.36 10.96 8 95487 6 42525834
Chronic fatigue syndrome 36.27 10.96 17 95478 329 42525511
Disseminated intravascular coagulation 36.21 10.96 6 95489 24788 42501052
Serotonin syndrome 36.13 10.96 7 95488 25838 42500002
Stress at work 36.07 10.96 16 95479 271 42525569
Hypercholesterolaemia 35.83 10.96 85 95410 12764 42513076
Mole excision 35.72 10.96 7 95488 0 42525840
Body fat disorder 35.11 10.96 13 95482 134 42525706
Breast disorder male 34.82 10.96 8 95487 9 42525831
Drug interaction 34.66 10.96 407 95088 266592 42259248
Panic disorder 34.24 10.96 26 95469 1251 42524589
Sexually transmitted disease 34.02 10.96 9 95486 25 42525815
Drug hypersensitivity 33.78 10.96 112 95383 99277 42426563
Osteoporosis 33.63 10.96 91 95404 14815 42511025
Arterial insufficiency 33.58 10.96 13 95482 153 42525687
Nipple pain 33.35 10.96 24 95471 1063 42524777
Muscle strain 33.30 10.96 46 95449 4531 42521309
Infusion related reaction 33.24 10.96 53 95442 60753 42465087
Seizure 33.16 10.96 148 95347 120413 42405427
Persistent depressive disorder 33.14 10.96 18 95477 481 42525359
Respiratory failure 33.05 10.96 161 95334 127971 42397869
Seborrhoeic dermatitis 33.02 10.96 31 95464 2001 42523839
Perineal pain 32.78 10.96 23 95472 978 42524862
Irritable bowel syndrome 32.50 10.96 46 95449 4635 42521205
Blood luteinising hormone decreased 32.47 10.96 12 95483 123 42525717
Genital pain 32.37 10.96 22 95473 888 42524952
Liver palpable 32.35 10.96 15 95480 283 42525557
Urinary tract infection 32.08 10.96 352 95143 98932 42426908
Nasal septum deviation 32.04 10.96 25 95470 1253 42524587
Pelvic pain 32.03 10.96 38 95457 3216 42522624
Lactic acidosis 31.39 10.96 33 95462 45228 42480612
Blood thyroid stimulating hormone decreased 31.33 10.96 32 95463 2291 42523549
Asthenia 31.31 10.96 837 94658 279956 42245884
Psychosexual disorder 31.16 10.96 12 95483 139 42525701
Testicular microlithiasis 30.85 10.96 8 95487 20 42525820
Nasal septal operation 30.64 10.96 10 95485 68 42525772
Varicocele repair 30.62 10.96 6 95489 0 42525840
Dyspareunia 30.59 10.96 9 95486 41 42525799
Renal failure 30.31 10.96 193 95302 143533 42382307
Granulomatous rosacea 30.13 10.96 12 95483 153 42525687
Spermatozoa progressive motility decreased 30.09 10.96 13 95482 206 42525634
Urinary tract obstruction 30.06 10.96 41 95454 3990 42521850
Social anxiety disorder 29.88 10.96 18 95477 588 42525252
Drug resistance 29.86 10.96 20 95475 34228 42491612
Shock 29.71 10.96 14 95481 29107 42496733
Hypotrichosis 29.08 10.96 8 95487 27 42525813
Prostate tenderness 28.82 10.96 9 95486 52 42525788
Hydrocele 28.51 10.96 32 95463 2551 42523289
Acute respiratory distress syndrome 28.45 10.96 16 95479 30092 42495748
Cardiogenic shock 28.24 10.96 23 95472 35617 42490223
Gingival recession 28.06 10.96 16 95479 471 42525369
Platypnoea 28.02 10.96 8 95487 32 42525808
Secondary hypogonadism 27.95 10.96 19 95476 767 42525073
Sleep disorder 27.86 10.96 194 95301 47901 42477939
Rotator cuff repair 27.78 10.96 15 95480 396 42525444
Essential hypertension 27.61 10.96 38 95457 3730 42522110
Renal impairment 27.56 10.96 140 95355 110088 42415752
Rash maculo-papular 27.55 10.96 26 95469 37477 42488363
Diabetic ketoacidosis 27.45 10.96 8 95487 22359 42503481
Lid sulcus deepened 27.37 10.96 10 95485 99 42525741
IgA nephropathy 27.22 10.96 30 95465 2344 42523496
Rhinitis allergic 27.04 10.96 38 95457 3804 42522036
Platelet distribution width increased 26.95 10.96 11 95484 150 42525690
Saliva altered 26.75 10.96 12 95483 209 42525631
Bone marrow failure 26.67 10.96 21 95474 33072 42492768
Hypophosphataemia 26.62 10.96 7 95488 20938 42504902
Respiratory depression 26.61 10.96 5 95490 18863 42506977
Penile vascular disorder 26.47 10.96 6 95489 6 42525834
Myelosuppression 26.41 10.96 31 95464 40430 42485410
Semen discolouration 25.95 10.96 8 95487 44 42525796
Urethral meatus stenosis 25.95 10.96 8 95487 44 42525796
Dermal cyst 25.94 10.96 27 95468 1976 42523864
Thrombocytopenia 25.86 10.96 287 95208 189992 42335848
Pneumocystis jirovecii pneumonia 25.86 10.96 12 95483 25169 42500671
Atrial fibrillation 25.85 10.96 448 95047 139145 42386695
Prostatic specific antigen increased 25.72 10.96 90 95405 16835 42509005
Ventricular fibrillation 25.72 10.96 18 95477 30105 42495735
Drug reaction with eosinophilia and systemic symptoms 25.62 10.96 34 95461 42041 42483799
Psychiatric symptom 25.58 10.96 39 95456 4202 42521638
Stomatitis 25.54 10.96 46 95449 50283 42475557
Benign tumour excision 25.52 10.96 5 95490 0 42525840
Liposuction 25.52 10.96 5 95490 0 42525840
Psychogenic erectile dysfunction 25.52 10.96 5 95490 0 42525840
Leydig cell tumour of the testis 25.52 10.96 5 95490 0 42525840
Inguinal hernia repair 25.43 10.96 13 95482 306 42525534
Renal cyst 25.43 10.96 64 95431 9975 42515865
Agranulocytosis 25.21 10.96 19 95476 30593 42495247
Prostatic operation 25.18 10.96 15 95480 480 42525360
Cardio-respiratory arrest 25.17 10.96 59 95436 58577 42467263
Therapy partial responder 24.86 10.96 7 95488 20014 42505826
Emotional poverty 24.82 10.96 17 95478 695 42525145
Ligament sprain 24.78 10.96 39 95456 4319 42521521
Balance disorder 24.62 10.96 187 95308 47458 42478382
Macular hole 24.43 10.96 13 95482 333 42525507
Genital lesion 24.41 10.96 12 95483 259 42525581
Incorrect route of product administration 24.32 10.96 12 95483 24293 42501547
Adenotonsillectomy 24.08 10.96 8 95487 58 42525782
Alanine aminotransferase increased 24.01 10.96 109 95386 88297 42437543
Neutrophil count decreased 24.00 10.96 68 95427 63347 42462493
Hallucination 23.97 10.96 215 95280 57292 42468548
Oestradiol increased 23.96 10.96 8 95487 59 42525781
Extrapyramidal disorder 23.90 10.96 4 95491 16408 42509432
Bronchopulmonary aspergillosis 23.75 10.96 7 95488 19422 42506418
Epilepsy 23.20 10.96 15 95480 26156 42499684
Shoulder operation 23.19 10.96 22 95473 1439 42524401
Pelvic floor muscle weakness 23.17 10.96 5 95490 3 42525837
Radiotherapy to prostate 23.17 10.96 5 95490 3 42525837
Primary hypogonadism 23.16 10.96 9 95486 107 42525733
Product use issue 23.08 10.96 91 95404 76660 42449180
Hepatic failure 22.98 10.96 31 95464 38069 42487771
Anaphylactic shock 22.95 10.96 12 95483 23505 42502335
Epicondylitis 22.63 10.96 14 95481 480 42525360
Nephropathy toxic 22.63 10.96 5 95490 16833 42509007
Memory impairment 22.62 10.96 191 95304 50031 42475809
Seborrhoeic keratosis 22.50 10.96 23 95472 1648 42524192
Micturition urgency 22.34 10.96 68 95427 11830 42514010
Daydreaming 22.26 10.96 16 95479 707 42525133
Rheumatoid arthritis 22.25 10.96 38 95457 42402 42483438
Seminoma 22.25 10.96 12 95483 316 42525524
Diverticulum 22.24 10.96 51 95444 7490 42518350
Feminisation acquired 22.20 10.96 7 95488 42 42525798
Vitamin D deficiency 22.07 10.96 53 95442 8020 42517820
Foreign body in reproductive tract 22.06 10.96 5 95490 5 42525835
Throat tightness 22.06 10.96 59 95436 9540 42516300
Androgen insensitivity syndrome 21.87 10.96 6 95489 20 42525820
Pneumonia 21.81 10.96 751 94744 421398 42104442
Gingival disorder 21.80 10.96 22 95473 1552 42524288
Bladder neck obstruction 21.78 10.96 9 95486 127 42525713
Acute kidney injury 21.48 10.96 643 94852 366694 42159146
Pancytopenia 21.43 10.96 165 95330 117578 42408262
Hepatic function abnormal 21.26 10.96 53 95442 51514 42474326
Depression suicidal 21.23 10.96 31 95464 3214 42522626
Mastectomy 21.22 10.96 6 95489 23 42525817
Anxiety disorder 21.13 10.96 24 95471 1939 42523901
Back injury 20.80 10.96 36 95459 4312 42521528
Prostate cancer 20.75 10.96 171 95324 44472 42481368
Thrombotic microangiopathy 20.67 10.96 4 95491 14778 42511062
Benign neoplasm of skin 20.59 10.96 9 95486 147 42525693
Inferior vena cava dilatation 20.47 10.96 16 95479 804 42525036
Hepatic cytolysis 20.44 10.96 18 95477 26826 42499014
Oestrogenic effect 20.41 10.96 4 95491 0 42525840
Biotin deficiency 20.41 10.96 4 95491 0 42525840
Blood follicle stimulating hormone abnormal 20.41 10.96 4 95491 0 42525840
Congenital ectopic bladder 20.41 10.96 4 95491 0 42525840
Dermatitis artefacta 20.41 10.96 4 95491 0 42525840
Physical disability 20.33 10.96 23 95472 1850 42523990
Cystitis 20.25 10.96 65 95430 11633 42514207
Intentional product misuse 20.18 10.96 71 95424 61829 42464011
Blunted affect 20.11 10.96 12 95483 385 42525455
Blood testosterone increased 20.07 10.96 21 95474 1546 42524294
Mental impairment 20.03 10.96 67 95428 12250 42513590
Erythema 20.01 10.96 152 95343 108641 42417199
Cerumen impaction 19.82 10.96 13 95482 494 42525346
Respiratory distress 19.67 10.96 40 95455 41780 42484060
Sex hormone binding globulin increased 19.43 10.96 5 95490 12 42525828
Acute hepatic failure 19.37 10.96 7 95488 17066 42508774
Drug dependence 19.30 10.96 22 95473 29072 42496768
Graft versus host disease 19.16 10.96 3 95492 12922 42512918
Seborrhoea 19.12 10.96 10 95485 247 42525593
Appendicectomy 19.09 10.96 20 95475 1475 42524365
Bladder outlet obstruction 19.07 10.96 9 95486 177 42525663
Pancreatitis 19.00 10.96 43 95452 43225 42482615
Facial bones fracture 18.99 10.96 25 95470 2351 42523489
Joint injury 18.92 10.96 74 95421 14602 42511238
Skin irritation 18.88 10.96 48 95447 7526 42518314
Alveolar bone resorption 18.87 10.96 5 95490 14 42525826
Syncope 18.74 10.96 320 95175 99086 42426754
Skin papilloma 18.73 10.96 27 95468 2767 42523073
Haemorrhoids 18.73 10.96 82 95413 17015 42508825
Bronchiectasis 18.67 10.96 85 95410 17934 42507906
Eosinophilia 18.62 10.96 28 95467 32871 42492969
Blood testosterone free decreased 18.58 10.96 7 95488 76 42525764
Invasive ductal breast carcinoma 18.58 10.96 7 95488 76 42525764
Blood follicle stimulating hormone decreased 18.58 10.96 7 95488 76 42525764
Ventricular enlargement 18.52 10.96 14 95481 669 42525171
Fear of crowded places 18.38 10.96 5 95490 16 42525824
Seasonal affective disorder 18.38 10.96 5 95490 16 42525824
Blood phosphorus increased 18.36 10.96 3 95492 12522 42513318
Affective disorder 18.35 10.96 41 95454 5919 42519921
Type V hyperlipidaemia 18.26 10.96 16 95479 944 42524896
Scrotal pain 18.22 10.96 16 95479 947 42524893
Pelvic discomfort 18.18 10.96 4 95491 3 42525837
Benign breast neoplasm 18.18 10.96 4 95491 3 42525837
Appendicitis 18.02 10.96 12 95483 20601 42505239
Suicide attempt 17.77 10.96 49 95446 46051 42479789
Acrochordon 17.75 10.96 12 95483 480 42525360
Palpitations 17.75 10.96 183 95312 50614 42475226
Rotator cuff syndrome 17.75 10.96 43 95452 6543 42519297
Reproductive tract hypoplasia, male 17.72 10.96 5 95490 19 42525821
Atrial enlargement 17.71 10.96 14 95481 715 42525125
Tubulointerstitial nephritis 17.71 10.96 27 95468 31521 42494319
Keratomileusis 17.65 10.96 4 95491 4 42525836
Plica syndrome 17.65 10.96 4 95491 4 42525836
Melanocytic hyperplasia 17.65 10.96 4 95491 4 42525836
Genital cyst 17.65 10.96 4 95491 4 42525836
Pulmonary embolism 17.62 10.96 177 95318 119435 42406405
Diabetes mellitus 17.59 10.96 72 95423 60015 42465825
Anaphylactic reaction 17.56 10.96 44 95451 42699 42483141
Cholecystectomy 17.55 10.96 29 95466 3345 42522495
Iris disorder 17.54 10.96 8 95487 145 42525695
Sex hormone binding globulin decreased 17.51 10.96 5 95490 20 42525820
Prostatic calcification 17.49 10.96 8 95487 146 42525694
Prostatism 17.49 10.96 10 95485 296 42525544
Enterococcal infection 17.39 10.96 3 95492 12036 42513804
Premature ageing 17.32 10.96 7 95488 93 42525747
Hypertrophy 17.30 10.96 12 95483 501 42525339
Capillaritis 17.13 10.96 23 95472 2205 42523635
Hypogammaglobulinaemia 17.09 10.96 3 95492 11888 42513952
Xanthopsia 17.01 10.96 8 95487 156 42525684
Testicular mass 17.01 10.96 8 95487 156 42525684
Electrocardiogram QT prolonged 17.00 10.96 53 95442 47892 42477948
Sprue-like enteropathy 16.97 10.96 13 95482 634 42525206
Orchitis 16.95 10.96 23 95472 2228 42523612
Rosacea 16.93 10.96 18 95477 1350 42524490
Therapy non-responder 16.86 10.96 62 95433 53297 42472543
Posterior reversible encephalopathy syndrome 16.84 10.96 4 95491 12817 42513023
Neuroleptic malignant syndrome 16.83 10.96 14 95481 21458 42504382
Rhinoplasty 16.76 10.96 4 95491 6 42525834
Penile prosthesis insertion 16.76 10.96 4 95491 6 42525834
Inner ear disorder 16.76 10.96 9 95486 235 42525605
Groin pain 16.61 10.96 40 95455 6064 42519776
Coma 16.42 10.96 63 95432 53491 42472349
Hair texture abnormal 16.40 10.96 10 95485 334 42525506
Hypothalamo-pituitary disorder 16.40 10.96 16 95479 1084 42524756
Pneumonitis 16.33 10.96 44 95451 41674 42484166
Lipoma 16.33 10.96 22 95473 2116 42523724
Hospice care 16.31 10.96 49 95446 8464 42517376
Bladder stenosis 16.30 10.96 5 95490 27 42525813
Malpositioned teeth 16.14 10.96 5 95490 28 42525812
Accidental overdose 16.14 10.96 24 95471 28306 42497534
Atrioventricular block first degree 16.04 10.96 41 95454 6450 42519390
Klebsiella infection 15.99 10.96 3 95492 11329 42514511
Bradyphrenia 15.98 10.96 36 95459 5226 42520614
Agoraphobia 15.97 10.96 9 95486 259 42525581
Dementia Alzheimer's type 15.91 10.96 10 95485 353 42525487
Myalgia 15.89 10.96 303 95192 95777 42430063
Hyponatraemia 15.84 10.96 148 95347 101314 42424526
Limb operation 15.81 10.96 15 95480 981 42524859
Penile exfoliation 15.81 10.96 7 95488 118 42525722
Lymphopenia 15.77 10.96 15 95480 21548 42504292
Asthenospermia 15.70 10.96 6 95489 68 42525772
Breast swelling 15.66 10.96 9 95486 269 42525571
Bladder disorder 15.61 10.96 29 95466 3670 42522170
Soft tissue mass 15.61 10.96 15 95480 997 42524843
Suprapubic pain 15.53 10.96 11 95484 475 42525365
Anger 15.47 10.96 64 95431 12954 42512886
Mammoplasty 15.43 10.96 4 95491 10 42525830
Exostosis of external ear canal 15.43 10.96 4 95491 10 42525830
Illusion 15.40 10.96 15 95480 1014 42524826
Thyroid cyst 15.32 10.96 5 95490 34 42525806
Interspinous osteoarthritis 15.31 10.96 3 95492 0 42525840
Benign breast lump removal 15.31 10.96 3 95492 0 42525840
Penile wart 15.31 10.96 3 95492 0 42525840
Pseudohermaphroditism male 15.31 10.96 3 95492 0 42525840
Urinary bladder suspension 15.31 10.96 3 95492 0 42525840
Blood oestrogen abnormal 15.31 10.96 3 95492 0 42525840
Penile repair 15.31 10.96 3 95492 0 42525840
Sigmoidectomy 15.31 10.96 3 95492 0 42525840
Psychophysiologic insomnia 15.31 10.96 3 95492 0 42525840
Cryotherapy 15.31 10.96 3 95492 0 42525840
Scar excision 15.31 10.96 3 95492 0 42525840
Pelvic organ injury 15.31 10.96 3 95492 0 42525840
Semen liquefaction 15.31 10.96 3 95492 0 42525840
Uvulopalatopharyngoplasty 15.31 10.96 3 95492 0 42525840
Genital injury 15.31 10.96 3 95492 0 42525840
Plastic surgery 15.31 10.96 3 95492 0 42525840
Varicose vein operation 15.31 10.96 3 95492 0 42525840
Penile haemorrhage 15.29 10.96 15 95480 1023 42524817
Lymphadenectomy 15.21 10.96 11 95484 491 42525349
Flat affect 15.18 10.96 15 95480 1032 42524808
Status epilepticus 15.12 10.96 8 95487 15570 42510270
Drug level increased 15.12 10.96 22 95473 26178 42499662
General physical health deterioration 15.11 10.96 243 95252 151003 42374837
Chlamydial infection 15.00 10.96 9 95486 292 42525548
Tendon rupture 14.99 10.96 46 95449 8037 42517803
Varicose vein 14.98 10.96 18 95477 1544 42524296
Brain oedema 14.97 10.96 9 95486 16318 42509522
Peripheral coldness 14.92 10.96 47 95448 8328 42517512
Decreased interest 14.83 10.96 24 95471 2721 42523119
Colitis 14.79 10.96 54 95441 46518 42479322
Chills 14.78 10.96 137 95358 93929 42431911
Exposure via father 14.73 10.96 7 95488 140 42525700
Urinary tract disorder 14.72 10.96 23 95472 2531 42523309
Transplant rejection 14.70 10.96 6 95489 13582 42512258
Body height decreased 14.69 10.96 30 95465 4070 42521770
Hyperglycaemia 14.68 10.96 53 95442 45806 42480034
Arthroscopic surgery 14.66 10.96 4 95491 13 42525827
Sexual relationship change 14.66 10.96 4 95491 13 42525827
Retrograde ejaculation 14.58 10.96 11 95484 524 42525316
Faeces discoloured 14.57 10.96 76 95419 16938 42508902
Treatment noncompliance 14.55 10.96 40 95455 37632 42488208
Thinking abnormal 14.47 10.96 42 95453 7119 42518721
Impaired fasting glucose 14.46 10.96 9 95486 312 42525528
Pericarditis 14.44 10.96 6 95489 13438 42512402
Prostatic dysplasia 14.43 10.96 4 95491 14 42525826
Fat tissue increased 14.42 10.96 11 95484 533 42525307
Intervertebral disc protrusion 14.41 10.96 56 95439 11016 42514824
Cortisol increased 14.39 10.96 8 95487 224 42525616
Floppy iris syndrome 14.38 10.96 9 95486 315 42525525
Product name confusion 14.37 10.96 6 95489 87 42525753
Transurethral prostatectomy 14.36 10.96 10 95485 420 42525420
Penile burning sensation 14.21 10.96 4 95491 15 42525825
Sclerotherapy 14.20 10.96 5 95490 44 42525796
Muscle disorder 14.18 10.96 25 95470 3039 42522801
Mitochondrial cytopathy 14.12 10.96 7 95488 154 42525686
N-terminal prohormone brain natriuretic peptide abnormal 14.11 10.96 8 95487 233 42525607
Cataract operation complication 14.07 10.96 6 95489 92 42525748
Obsessive-compulsive disorder 14.06 10.96 40 95455 6703 42519137
Vitreous floaters 14.05 10.96 30 95465 4200 42521640
Drug intolerance 14.02 10.96 114 95381 80310 42445530
Red blood cell analysis abnormal 14.01 10.96 4 95491 16 42525824
Urinary straining 14.01 10.96 4 95491 16 42525824
Phobia 14.00 10.96 7 95488 157 42525683
Toxic epidermal necrolysis 13.98 10.96 24 95471 26726 42499114
Abnormal loss of weight 13.91 10.96 33 95462 4954 42520886
Meniscus injury 13.84 10.96 22 95473 2457 42523383
Obstructive airways disorder 13.83 10.96 99 95396 24660 42501180
Genital disorder 13.82 10.96 4 95491 17 42525823
Norepinephrine increased 13.82 10.96 4 95491 17 42525823
Drug-induced liver injury 13.78 10.96 42 95453 38231 42487609
Cardiac failure 13.78 10.96 163 95332 106693 42419147
Full blood count decreased 13.76 10.96 86 95409 20474 42505366
Social avoidant behaviour 13.73 10.96 26 95469 3338 42522502
Vision blurred 13.66 10.96 182 95313 53517 42472323
Creatinine urine decreased 13.64 10.96 5 95490 50 42525790
Aspartate aminotransferase increased 13.63 10.96 109 95386 77054 42448786
Xerophthalmia 13.61 10.96 7 95488 167 42525673
Peritonitis 13.59 10.96 13 95482 18620 42507220
Swelling 13.55 10.96 70 95425 54815 42471025
Tinnitus 13.53 10.96 111 95384 28827 42497013
Blepharitis 13.43 10.96 19 95476 1914 42523926
Adrenal disorder 13.42 10.96 15 95480 1190 42524650
Hypoglycaemia 13.32 10.96 79 95416 59775 42466065
Alpha 2 globulin decreased 13.29 10.96 4 95491 20 42525820
Otosalpingitis 13.29 10.96 4 95491 20 42525820
Sinus tachycardia 13.29 10.96 16 95479 20637 42505203
Histamine intolerance 13.24 10.96 3 95492 3 42525837
Prostatic atrophy 13.24 10.96 3 95492 3 42525837
Liver disorder 13.23 10.96 45 95450 39599 42486241
Dermatitis atopic 13.21 10.96 59 95436 12345 42513495
Inguinal hernia 13.21 10.96 47 95448 8865 42516975
Nasal discomfort 13.20 10.96 17 95478 1565 42524275
Prostatic haemorrhage 13.15 10.96 8 95487 266 42525574
Beta globulin increased 13.13 10.96 4 95491 21 42525819
Free androgen index decreased 13.13 10.96 4 95491 21 42525819
Full blood count abnormal 13.12 10.96 113 95382 29763 42496077
Genital herpes 13.11 10.96 12 95483 750 42525090
Hypoxia 13.07 10.96 97 95398 69689 42456151
Migraine with aura 13.02 10.96 13 95482 906 42524934
Musculoskeletal stiffness 12.98 10.96 76 95419 57689 42468151
Infection 12.94 10.96 175 95320 111893 42413947
Listless 12.94 10.96 18 95477 1785 42524055
Hair colour changes 12.93 10.96 20 95475 2182 42523658
Dyshidrotic eczema 12.92 10.96 7 95488 186 42525654
Orchidectomy 12.90 10.96 5 95490 59 42525781
Empty sella syndrome 12.83 10.96 5 95490 60 42525780
Oesophageal carcinoma 12.79 10.96 3 95492 9693 42516147
Plantar fascial fibromatosis 12.78 10.96 3 95492 4 42525836
Serum serotonin decreased 12.78 10.96 3 95492 4 42525836
Exposure via body fluid 12.76 10.96 6 95489 117 42525723
Rales 12.73 10.96 55 95440 11345 42514495
End stage renal disease 12.73 10.96 11 95484 16547 42509293
Emotional disorder 12.72 10.96 37 95458 6277 42519563
COVID-19 12.70 10.96 183 95312 115765 42410075
Respiratory arrest 12.68 10.96 28 95467 28396 42497444
Transaminases increased 12.64 10.96 35 95460 32850 42492990
Prostatic specific antigen decreased 12.62 10.96 7 95488 195 42525645
Mood swings 12.61 10.96 46 95449 8780 42517060
Neoplasm progression 12.59 10.96 29 95466 28971 42496869
Exposure to communicable disease 12.56 10.96 7 95488 197 42525643
Blood testosterone free increased 12.55 10.96 4 95491 25 42525815
Viral acanthoma 12.55 10.96 4 95491 25 42525815
Blood pressure fluctuation 12.43 10.96 26 95469 26882 42498958
Pneumothorax 12.41 10.96 21 95474 23522 42502318
Post-traumatic stress disorder 12.37 10.96 20 95475 2265 42523575
Testis discomfort 12.28 10.96 4 95491 27 42525813
Poisoning 12.26 10.96 9 95486 14690 42511150
Genital rash 12.21 10.96 12 95483 820 42525020
Reading disorder 12.19 10.96 10 95485 539 42525301
Prostatic obstruction 12.19 10.96 6 95489 130 42525710
Adjustment disorder 12.12 10.96 15 95480 1327 42524513
Mitral valve prolapse 12.04 10.96 11 95484 686 42525154
Sedation 12.04 10.96 32 95463 30443 42495397
Haematochezia 12.03 10.96 79 95416 58357 42467483
Eyelid cyst 12.03 10.96 3 95492 6 42525834
Alpha globulin increased 12.03 10.96 3 95492 6 42525834
Cystitis radiation 11.98 10.96 6 95489 135 42525705
Blood follicle stimulating hormone increased 11.95 10.96 7 95488 217 42525623
Tendon calcification 11.94 10.96 5 95490 73 42525767
Androgenetic alopecia 11.92 10.96 4 95491 30 42525810
Hepatotoxicity 11.89 10.96 24 95471 25143 42500697
Nipple disorder 11.89 10.96 7 95488 219 42525621
Hair growth abnormal 11.87 10.96 13 95482 1009 42524831
Snoring 11.86 10.96 27 95468 3946 42521894
Febrile bone marrow aplasia 11.85 10.96 4 95491 10177 42515663
Adrenal insufficiency 11.82 10.96 15 95480 18909 42506931
Urine calcium/creatinine ratio increased 11.81 10.96 4 95491 31 42525809
Hypohidrosis 11.69 10.96 7 95488 226 42525614
Hepatocellular injury 11.69 10.96 22 95473 23656 42502184
Glomerular filtration rate abnormal 11.60 10.96 14 95481 1206 42524634
Skin neoplasm excision 11.57 10.96 9 95486 449 42525391
Blood bilirubin increased 11.52 10.96 52 95443 42200 42483640
Colitis ulcerative 11.50 10.96 26 95469 26149 42499691
Skin laceration 11.49 10.96 62 95433 13996 42511844
Haematuria traumatic 11.47 10.96 8 95487 337 42525503
Uterine haemorrhage 11.43 10.96 3 95492 8 42525832
Frequent bowel movements 11.37 10.96 19 95476 21388 42504452
Wrist surgery 11.37 10.96 6 95489 151 42525689
Fixed eruption 11.33 10.96 20 95475 2434 42523406
Dyspepsia 11.30 10.96 142 95353 41210 42484630
Ankle fracture 11.27 10.96 30 95465 4836 42521004
Pancreatitis acute 11.27 10.96 38 95457 33526 42492314
Bacterial infection 11.22 10.96 29 95466 27850 42497990
Milia 11.20 10.96 5 95490 86 42525754
Contraindicated product administered 11.19 10.96 25 95470 25247 42500593
Plasma cell myeloma 11.19 10.96 159 95336 47419 42478421
Pelvic fracture 11.18 10.96 21 95474 2680 42523160
Hydrocele operation 11.17 10.96 3 95492 9 42525831
Obsessive-compulsive personality disorder 11.13 10.96 6 95489 158 42525682
Aplastic anaemia 11.11 10.96 7 95488 12377 42513463
Muscular weakness 11.08 10.96 255 95240 83243 42442597
Motion sickness 11.04 10.96 7 95488 251 42525589
Elbow operation 11.02 10.96 6 95489 161 42525679
Contusion 10.97 10.96 143 95352 41842 42483998

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Erectile dysfunction 845.01 10.97 342 65266 18214 110505477
Post 5-alpha-reductase inhibitor syndrome 558.58 10.97 91 65517 31 110523660
Loss of libido 523.85 10.97 153 65455 2980 110520711
Libido decreased 431.54 10.97 154 65454 5781 110517910
Testicular pain 346.83 10.97 105 65503 2324 110521367
Gynaecomastia 255.92 10.97 121 65487 9369 110514322
Penile size reduced 247.31 10.97 44 65564 55 110523636
Suicidal ideation 232.98 10.97 283 65325 93654 110430037
Benign prostatic hyperplasia 184.50 10.97 122 65486 18112 110505579
Ejaculation disorder 184.14 10.97 47 65561 537 110523154
Sexual dysfunction 174.17 10.97 90 65518 8440 110515251
Semen volume decreased 174.13 10.97 31 65577 39 110523652
Depression 169.61 10.97 492 65116 316843 110206848
Right atrial hypertrophy 157.50 10.97 43 65565 648 110523043
Urinary retention 150.55 10.97 196 65412 69487 110454204
Haematuria 146.93 10.97 212 65396 82793 110440898
Atrial fibrillation 144.43 10.97 378 65230 229264 110294427
Death 136.31 10.97 792 64816 698077 109825614
Organic erectile dysfunction 135.03 10.97 27 65581 86 110523605
Infertility male 134.32 10.97 27 65581 89 110523602
Penis disorder 123.71 10.97 39 65569 991 110522700
Right ventricular hypertrophy 122.68 10.97 44 65564 1675 110522016
Systemic lupus erythematosus 122.55 10.97 7 65601 254331 110269360
Genital hypoaesthesia 112.38 10.97 26 65582 189 110523502
Maternal exposure during pregnancy 111.53 10.97 11 65597 254872 110268819
Genital paraesthesia 108.07 10.97 21 65587 55 110523636
Fall 106.76 10.97 667 64941 602815 109920876
Pericarditis 105.65 10.97 6 65602 219108 110304583
Drug hypersensitivity 105.36 10.97 70 65538 454020 110069671
Male reproductive tract disorder 104.06 10.97 21 65587 71 110523620
Infusion related reaction 103.98 10.97 48 65560 381114 110142577
Rheumatoid arthritis 103.89 10.97 25 65583 299588 110224103
Testicular atrophy 100.02 10.97 27 65581 389 110523302
Ejaculation failure 97.14 10.97 26 65582 362 110523329
Dizziness 95.24 10.97 724 64884 697469 109826222
IVth nerve paralysis 92.00 10.97 28 65580 631 110523060
Blood testosterone decreased 91.45 10.97 41 65567 2807 110520884
Helicobacter infection 90.80 10.97 4 65604 181873 110341818
Obstruction 90.35 10.97 51 65557 5701 110517990
Treatment failure 88.83 10.97 27 65581 277207 110246484
Male orgasmic disorder 88.72 10.97 18 65590 63 110523628
Swelling 88.55 10.97 49 65559 350992 110172699
Joint swelling 87.85 10.97 80 65528 442765 110080926
Orthostatic hypotension 86.31 10.97 147 65461 66102 110457589
Drug ineffective 86.00 10.97 540 65068 1520000 109003691
Bronchial wall thickening 83.74 10.97 40 65568 3167 110520524
Prostate cancer 83.04 10.97 107 65501 37534 110486157
Folliculitis 82.68 10.97 4 65604 167649 110356042
Hepatic enzyme increased 82.09 10.97 44 65564 320848 110202843
Syncope 81.52 10.97 285 65323 202251 110321440
Bronchial secretion retention 80.15 10.97 45 65563 4979 110518712
Drug intolerance 79.96 10.97 74 65534 406438 110117253
Contraindicated product administered 78.06 10.97 25 65583 248242 110275449
Glossodynia 77.98 10.97 18 65590 221986 110301705
Aortic valve stenosis 77.94 10.97 48 65560 6302 110517389
Vomiting 77.41 10.97 279 65329 910396 109613295
Stomatitis 75.28 10.97 33 65575 270209 110253482
Pulmonary function test abnormal 74.96 10.97 43 65565 4957 110518734
Cardiac failure congestive 74.72 10.97 228 65380 150772 110372919
Synovitis 73.97 10.97 35 65573 274057 110249634
Fibromyalgia 73.14 10.97 8 65600 170901 110352790
Muscle atrophy 71.86 10.97 61 65547 13193 110510498
Haematospermia 71.84 10.97 19 65589 252 110523439
Depressed mood 71.51 10.97 129 65479 60680 110463011
Arthropathy 71.25 10.97 41 65567 287481 110236210
Urine flow decreased 71.22 10.97 28 65580 1378 110522313
Muscle injury 70.60 10.97 3 65605 140804 110382887
Hallucination 68.91 10.97 172 65436 101260 110422431
Acute kidney injury 67.92 10.97 624 64984 634806 109888885
Exposure via body fluid 67.08 10.97 19 65589 330 110523361
Diastolic dysfunction 67.07 10.97 57 65551 12347 110511344
Wound 66.30 10.97 28 65580 234409 110289282
Alopecia 65.32 10.97 72 65536 364681 110159010
Discomfort 65.09 10.97 23 65585 214684 110309007
Breast tenderness 63.12 10.97 31 65577 2609 110521082
Anxiety 62.50 10.97 384 65224 344694 110178997
Off label use 62.39 10.97 580 65028 1499605 109024086
Semen analysis abnormal 61.68 10.97 10 65598 3 110523688
Impaired healing 61.50 10.97 20 65588 196697 110326994
C-reactive protein abnormal 61.16 10.97 4 65604 129691 110394000
Panic attack 60.31 10.97 80 65528 28860 110494831
Hypersensitivity 59.75 10.97 92 65516 403906 110119785
Hypoacusis 59.52 10.97 88 65520 35103 110488588
Therapeutic product effect decreased 58.89 10.97 36 65572 244280 110279411
Chest X-ray abnormal 58.61 10.97 45 65563 8442 110515249
Azoospermia 58.55 10.97 16 65592 242 110523449
Libido disorder 58.49 10.97 17 65591 325 110523366
Bursitis 58.44 10.97 5 65603 129913 110393778
Breast cancer male 58.05 10.97 17 65591 334 110523357
Hypotension 57.75 10.97 518 65090 523331 110000360
International normalised ratio increased 57.74 10.97 146 65462 86626 110437065
Abdominal discomfort 57.00 10.97 91 65517 393767 110129924
Hypospermia 56.43 10.97 10 65598 12 110523679
Dysuria 56.38 10.97 116 65492 60115 110463576
Prostatic pain 56.21 10.97 16 65592 283 110523408
Prostatic disorder 55.66 10.97 28 65580 2481 110521210
Pyrexia 55.34 10.97 310 65298 897955 109625736
IgA nephropathy 54.95 10.97 30 65578 3143 110520548
Hepatic vein dilatation 54.76 10.97 15 65593 229 110523462
Penile pain 54.48 10.97 22 65586 1162 110522529
Intervertebral disc degeneration 54.03 10.97 60 65548 18025 110505666
Spermatozoa abnormal 53.28 10.97 9 65599 6 110523685
Sinusitis 52.63 10.97 59 65549 296629 110227062
Musculoskeletal stiffness 52.59 10.97 53 65555 279769 110243922
Irritable bowel syndrome 52.57 10.97 16 65592 164199 110359492
Testicular disorder 52.47 10.97 16 65592 363 110523328
Inflammation 51.63 10.97 25 65583 193213 110330478
Nausea 51.60 10.97 477 65131 1235213 109288478
Mood altered 50.69 10.97 63 65545 21312 110502379
Liver palpable 49.37 10.97 15 65593 336 110523355
Wrong technique in product usage process 49.05 10.97 138 65470 87210 110436481
Ill-defined disorder 48.93 10.97 16 65592 156837 110366854
Intentional product use issue 48.86 10.97 45 65563 247861 110275830
Apathy 48.73 10.97 54 65554 16185 110507506
Prostatitis 48.26 10.97 32 65576 4769 110518922
Obstructive airways disorder 48.14 10.97 93 65515 46056 110477635
Sleep apnoea syndrome 47.80 10.97 86 65522 40361 110483330
C-reactive protein increased 47.32 10.97 36 65572 217883 110305808
Prostatic specific antigen increased 47.18 10.97 47 65561 12464 110511227
Scrotal disorder 46.93 10.97 10 65598 47 110523644
Orgasm abnormal 46.89 10.97 13 65595 208 110523483
Upper gastrointestinal haemorrhage 46.32 10.97 96 65512 50000 110473691
Plasma cell myeloma 46.23 10.97 110 65498 62826 110460865
Facet joint syndrome 45.61 10.97 3 65605 96825 110426866
Semen viscosity decreased 45.01 10.97 7 65601 0 110523691
Pain 45.01 10.97 357 65251 954598 109569093
Gastrointestinal haemorrhage 44.91 10.97 206 65402 165312 110358379
Lip dry 44.61 10.97 4 65604 100079 110423612
Injury 44.30 10.97 25 65583 177240 110346451
Gout 43.54 10.97 78 65530 36488 110487203
Blood cholesterol increased 43.46 10.97 28 65580 184757 110338934
Full blood count abnormal 43.39 10.97 100 65508 55952 110467739
Migraine 43.19 10.97 24 65584 171628 110352063
Dark circles under eyes 43.10 10.97 15 65593 522 110523169
Disturbance in attention 43.02 10.97 106 65502 61889 110461802
Joint range of motion decreased 42.53 10.97 10 65598 121822 110401869
Breast disorder male 42.52 10.97 7 65601 3 110523688
Asthenia 42.47 10.97 608 65000 688391 109835300
Bronchiectasis 42.37 10.97 77 65531 36416 110487275
Granulomatous rosacea 42.07 10.97 12 65596 214 110523477
Hallucination, visual 41.54 10.97 80 65528 39525 110484166
Type 2 diabetes mellitus 41.48 10.97 27 65581 177205 110346486
Skin atrophy 41.42 10.97 33 65575 6531 110517160
Anorgasmia 41.37 10.97 20 65588 1626 110522065
Platelet distribution width increased 41.24 10.97 11 65597 151 110523540
Gastrointestinal disorder 40.88 10.97 50 65558 241902 110281789
Dehydroepiandrosterone decreased 40.62 10.97 8 65600 23 110523668
Prostate tenderness 39.32 10.97 9 65599 62 110523629
Arrhythmia 39.13 10.97 110 65498 69465 110454226
Faeces discoloured 38.62 10.97 71 65537 33877 110489814
Platypnoea 38.59 10.97 8 65600 32 110523659
Hormone receptor positive breast cancer 38.30 10.97 14 65594 563 110523128
Hypogonadism male 38.26 10.97 11 65597 202 110523489
Testicular cyst 38.01 10.97 8 65600 35 110523656
Male sexual dysfunction 37.91 10.97 12 65596 309 110523382
Haemoglobin decreased 37.82 10.97 265 65343 248462 110275229
Headache 37.45 10.97 339 65269 882038 109641653
Pemphigoid 37.31 10.97 52 65556 19655 110504036
Cerebrovascular accident 36.82 10.97 208 65400 181076 110342615
Capillaritis 36.63 10.97 21 65587 2418 110521273
Pollakiuria 36.61 10.97 81 65527 44114 110479577
Wound infection 35.54 10.97 7 65601 96458 110427233
Bradycardia 35.34 10.97 184 65424 155333 110368358
Ventricular enlargement 35.21 10.97 14 65594 710 110522981
Condition aggravated 34.91 10.97 274 65334 734562 109789129
Seminoma 34.76 10.97 11 65597 283 110523408
Inferior vena cava dilatation 34.53 10.97 15 65593 952 110522739
Daydreaming 34.49 10.97 16 65592 1186 110522505
Anhedonia 34.25 10.97 44 65564 15384 110508307
Androgen deficiency 34.12 10.97 9 65599 118 110523573
Lid sulcus deepened 33.89 10.97 10 65598 202 110523489
Osteoarthritis 33.84 10.97 35 65573 182588 110341103
Product use issue 33.15 10.97 86 65522 311609 110212082
Balance disorder 32.31 10.97 146 65462 116414 110407277
Reproductive tract hypoplasia, male 32.15 10.97 5 65603 0 110523691
Leydig cell tumour of the testis 32.15 10.97 5 65603 0 110523691
Depression suicidal 32.05 10.97 25 65583 4799 110518892
Urethral meatus stenosis 31.71 10.97 7 65601 40 110523651
Peripheral venous disease 31.21 10.97 6 65602 84111 110439580
Genital burning sensation 31.20 10.97 11 65597 398 110523293
Sperm concentration decreased 30.54 10.97 8 65600 102 110523589
Myoglobin blood increased 30.46 10.97 23 65585 4209 110519482
Prostatomegaly 30.41 10.97 23 65585 4219 110519472
Emotional poverty 30.33 10.97 14 65594 1026 110522665
Weight increased 30.22 10.97 137 65471 419507 110104184
Agitation 30.14 10.97 140 65468 112911 110410780
Nasopharyngitis 30.07 10.97 126 65482 394235 110129456
Toxicity to various agents 29.97 10.97 165 65443 480390 110043301
Psoriatic arthropathy 29.84 10.97 44 65564 196717 110326974
Rales 29.74 10.97 53 65555 24686 110499005
Micturition urgency 29.39 10.97 46 65562 19274 110504417
Atrial enlargement 28.97 10.97 14 65594 1137 110522554
Myalgia 28.73 10.97 228 65380 222153 110301538
Epilepsy 28.26 10.97 12 65596 100197 110423494
Myopathy 28.14 10.97 52 65556 24908 110498783
Saliva altered 27.87 10.97 11 65597 547 110523144
Liver injury 27.67 10.97 29 65579 150384 110373307
Testis cancer 27.31 10.97 14 65594 1291 110522400
Blister 27.15 10.97 59 65549 227317 110296374
Blood thyroid stimulating hormone decreased 26.94 10.97 27 65581 7212 110516479
Somatic symptom disorder 26.89 10.97 19 65589 3140 110520551
Psychiatric symptom 26.55 10.97 30 65578 9183 110514508
Atrioventricular block first degree 26.13 10.97 37 65571 14188 110509503
Pudendal canal syndrome 26.04 10.97 5 65603 12 110523679
Lower respiratory tract infection 25.90 10.97 67 65541 243039 110280652
Biotin deficiency 25.72 10.97 4 65604 0 110523691
Orgasmic sensation decreased 25.54 10.97 6 65602 47 110523644
Myelosuppression 25.50 10.97 12 65596 94328 110429363
Penile exfoliation 25.31 10.97 7 65601 111 110523580
Fear of crowded places 25.23 10.97 5 65603 15 110523676
Perineal pain 25.08 10.97 14 65594 1531 110522160
Floppy iris syndrome 25.03 10.97 9 65599 345 110523346
Prostatism 25.02 10.97 7 65601 116 110523575
Blood glucose increased 24.93 10.97 149 65459 132347 110391344
Body fat disorder 24.91 10.97 9 65599 350 110523341
Red blood cell sedimentation rate increased 24.39 10.97 8 65600 78294 110445397
Hypogonadism 24.29 10.97 15 65593 1979 110521712
Atrial flutter 24.21 10.97 48 65560 24214 110499477
Mental impairment 24.07 10.97 46 65562 22593 110501098
Fixed eruption 24.02 10.97 20 65588 4212 110519479
Blood creatinine increased 23.89 10.97 188 65420 182701 110340990
Bradyphrenia 23.79 10.97 32 65576 11696 110511995
Bladder cancer 23.79 10.97 43 65565 20249 110503442
Hospice care 23.74 10.97 33 65575 12440 110511251
Trans-sexualism 23.49 10.97 4 65604 3 110523688
Product administration error 23.08 10.97 61 65547 37156 110486535
Injection site reaction 23.07 10.97 12 65596 89058 110434633
Plica syndrome 22.95 10.97 4 65604 4 110523687
Blood creatine phosphokinase increased 22.90 10.97 95 65513 72982 110450709
Hepatitis cholestatic 22.90 10.97 39 65569 17527 110506164
Penile haemorrhage 22.72 10.97 11 65597 897 110522794
Feeling abnormal 22.64 10.97 184 65424 180527 110343164
Productive cough 22.45 10.97 130 65478 114175 110409516
Hypertrophy 22.42 10.97 11 65597 924 110522767
Drug ineffective for unapproved indication 22.30 10.97 17 65591 102821 110420870
Dyspnoea exertional 22.19 10.97 121 65487 103939 110419752
Arthritis 22.13 10.97 41 65567 167545 110356146
N-terminal prohormone brain natriuretic peptide abnormal 22.05 10.97 8 65600 315 110523376
Subdural haemorrhage 21.76 10.97 23 65585 6535 110517156
Illusion 21.70 10.97 14 65594 1993 110521698
Haemorrhage intracranial 21.67 10.97 51 65557 28918 110494773
Splenomegaly 21.54 10.97 46 65562 24452 110499239
Varicocele 21.53 10.97 5 65603 37 110523654
Prostatic haemorrhage 21.53 10.97 7 65601 197 110523494
Sprue-like enteropathy 21.27 10.97 13 65595 1683 110522008
Blunted affect 21.25 10.97 9 65599 537 110523154
On and off phenomenon 21.24 10.97 19 65589 4405 110519286
Cardiac failure chronic 21.17 10.97 33 65575 13778 110509913
Infection 21.15 10.97 127 65481 362073 110161618
Iris disorder 21.01 10.97 7 65601 213 110523478
Prescribed overdose 20.96 10.97 13 65595 87568 110436123
Xanthopsia 20.88 10.97 8 65600 367 110523324
Haematuria traumatic 20.88 10.97 8 65600 367 110523324
Congenital hiatus hernia 20.86 10.97 22 65586 6237 110517454
Subdural haematoma 20.86 10.97 58 65550 36396 110487295
Exostosis of external ear canal 20.72 10.97 4 65604 10 110523681
Conjunctivitis allergic 20.71 10.97 23 65585 6908 110516783
Malpositioned teeth 20.57 10.97 5 65603 46 110523645
Ventricular extrasystoles 20.47 10.97 43 65565 22598 110501093
Pregnancy 20.36 10.97 3 65605 51064 110472627
Exposure during pregnancy 20.35 10.97 43 65565 167381 110356310
Gingival disorder 20.26 10.97 18 65590 4135 110519556
Haematemesis 20.25 10.97 79 65529 59029 110464662
Hyperkalaemia 20.23 10.97 144 65464 135652 110388039
Nipple pain 20.21 10.97 11 65597 1145 110522546
Melanocytic hyperplasia 20.18 10.97 4 65604 12 110523679
Fatigue 20.07 10.97 897 64711 1215061 109308630
Parkinsonism 19.90 10.97 42 65566 22145 110501546
Coronary artery stenosis 19.89 10.97 32 65576 13726 110509965
Soft tissue mass 19.87 10.97 12 65596 1521 110522170
Autoimmune disorder 19.86 10.97 7 65601 65476 110458215
Musculoskeletal pain 19.83 10.97 50 65558 182973 110340718
Glomerular filtration rate abnormal 19.51 10.97 14 65594 2369 110521322
Liver disorder 19.50 10.97 34 65574 142209 110381482
Androgen insensitivity syndrome 19.50 10.97 4 65604 15 110523676
Interstitial lung disease 19.38 10.97 33 65575 139301 110384390
Tendon rupture 19.34 10.97 32 65576 14046 110509645
Breast mass 19.31 10.97 24 65584 8117 110515574
Penile curvature 19.29 10.97 4 65604 16 110523675
Teratospermia 19.29 10.97 3 65605 0 110523691
Androgens abnormal 19.29 10.97 3 65605 0 110523691
Haemorrhage urinary tract 19.04 10.97 15 65593 2921 110520770
Red blood cell analysis abnormal 18.91 10.97 4 65604 18 110523673
Testicular swelling 18.88 10.97 12 65596 1664 110522027
Total lung capacity abnormal 18.74 10.97 18 65590 4565 110519126
Urinary tract obstruction 18.70 10.97 19 65589 5158 110518533
Hip arthroplasty 18.67 10.97 5 65603 55808 110467883
Ageusia 18.57 10.97 38 65570 19607 110504084
Ophthalmoplegia 18.55 10.97 16 65592 3534 110520157
Coronary artery disease 18.53 10.97 88 65520 71602 110452089
Serotonin syndrome 18.50 10.97 6 65602 59147 110464544
Haemorrhagic stroke 18.48 10.97 31 65577 13758 110509933
Alveolar bone resorption 18.46 10.97 5 65603 73 110523618
Hypoaesthesia 18.44 10.97 110 65498 314113 110209578
Bladder stenosis 18.40 10.97 4 65604 21 110523670
Breast pain 18.35 10.97 26 65582 9974 110513717
Bundle branch block right 18.33 10.97 29 65579 12262 110511429
Full blood count decreased 18.29 10.97 51 65557 32048 110491643
Mucosal inflammation 18.29 10.97 18 65590 96123 110427568
Lower limb fracture 18.29 10.97 11 65597 75337 110448354
Haemorrhage 18.20 10.97 117 65491 106575 110417116
Cognitive disorder 18.15 10.97 101 65507 87410 110436281
Semen discolouration 18.10 10.97 4 65604 23 110523668
Throat tightness 17.91 10.97 52 65556 33437 110490254
Nail disorder 17.90 10.97 6 65602 57929 110465762
Suprapubic pain 17.74 10.97 10 65598 1115 110522576
Exposure via father 17.54 10.97 5 65603 89 110523602
Night sweats 17.49 10.97 33 65575 133950 110389741
Dysphagia 17.44 10.97 153 65455 153447 110370244
Gingival recession 17.25 10.97 11 65597 1535 110522156
Blood oestrogen abnormal 17.21 10.97 3 65605 3 110523688
Arthralgia 17.09 10.97 343 65265 779289 109744402
Mitochondrial cytopathy 17.01 10.97 7 65601 388 110523303
Product name confusion 16.79 10.97 6 65602 226 110523465
Sciatica 16.78 10.97 18 65590 92381 110431310
Oligospermia 16.74 10.97 4 65604 34 110523657
Dementia Alzheimer's type 16.69 10.97 9 65599 920 110522771
Obsessive-compulsive disorder 16.62 10.97 21 65587 7220 110516471
Drug abuse 16.61 10.97 52 65556 177359 110346332
Malignant melanoma in situ 16.59 10.97 15 65593 3527 110520164
Obesity 16.55 10.97 26 65582 113325 110410366
Constipation 16.46 10.97 301 65307 357485 110166206
Embolic stroke 16.45 10.97 23 65585 8720 110514971
Social avoidant behaviour 16.36 10.97 18 65590 5351 110518340
Muscle disorder 16.36 10.97 20 65588 6652 110517039
Back injury 16.32 10.97 4 65604 47395 110476296
Peripheral swelling 16.32 10.97 157 65451 403877 110119814
Road traffic accident 16.29 10.97 24 65584 107374 110416317
Nocturia 16.22 10.97 33 65575 16957 110506734
Alcohol intolerance 16.18 10.97 7 65601 440 110523251
Brain natriuretic peptide increased 16.10 10.97 26 65582 11183 110512508
Blood urea increased 16.10 10.97 70 65538 54887 110468804
Melaena 16.06 10.97 82 65526 68675 110455016
Affective disorder 16.05 10.97 26 65582 11215 110512476
Incorrect route of product administration 16.05 10.97 9 65599 64052 110459639
Multiple organ dysfunction syndrome 16.01 10.97 42 65566 151668 110372023
Product use in unapproved indication 15.96 10.97 179 65429 447198 110076493
Skin irritation 15.94 10.97 32 65576 16287 110507404
Delusion of replacement 15.77 10.97 6 65602 270 110523421
Dyspnoea at rest 15.76 10.97 22 65586 8324 110515367
Major depression 15.76 10.97 25 65583 10596 110513095
Genital pain 15.71 10.97 10 65598 1390 110522301
Penile burning sensation 15.68 10.97 3 65605 7 110523684
Sclerotherapy 15.65 10.97 4 65604 46 110523645
Exostosis 15.59 10.97 4 65604 45952 110477739
Cataract operation complication 15.58 10.97 6 65602 279 110523412
Phlebosclerosis 15.54 10.97 5 65603 136 110523555
Ludwig angina 15.48 10.97 6 65602 284 110523407
Antineutrophil cytoplasmic antibody positive 15.44 10.97 17 65591 5059 110518632
Gastrooesophageal reflux disease 15.41 10.97 169 65439 179807 110343884
Myocardial infarction 15.37 10.97 178 65430 191905 110331786
Injection site erythema 15.33 10.97 20 65588 94156 110429535
Stenosis 15.32 10.97 14 65594 3337 110520354
Confusional state 15.29 10.97 375 65233 468305 110055386
Listless 15.28 10.97 16 65592 4499 110519192
Cryptorchism 15.27 10.97 4 65604 51 110523640
Renal atrophy 15.24 10.97 12 65596 2334 110521357
Mite allergy 15.22 10.97 18 65590 5785 110517906
Spermatozoa progressive motility decreased 15.20 10.97 5 65603 146 110523545
Breath sounds abnormal 15.11 10.97 41 65567 25363 110498328
Lethargy 14.98 10.97 101 65507 93475 110430216
Dermatitis atopic 14.97 10.97 41 65567 25500 110498191
Anger 14.81 10.97 34 65574 18973 110504718
Patellofemoral pain syndrome 14.75 10.97 7 65601 546 110523145
Blood magnesium decreased 14.74 10.97 35 65573 19961 110503730
Transient ischaemic attack 14.73 10.97 76 65532 63906 110459785
Renal cyst 14.70 10.97 33 65575 18139 110505552
Genital cyst 14.67 10.97 4 65604 60 110523631
Blood luteinising hormone decreased 14.56 10.97 5 65603 167 110523524
Flat affect 14.55 10.97 12 65596 2493 110521198
Product substitution issue 14.51 10.97 38 65570 23023 110500668
Spirometry abnormal 14.33 10.97 17 65591 5480 110518211
Premature ejaculation 14.20 10.97 4 65604 68 110523623
Coeliac disease 14.20 10.97 4 65604 43183 110480508
Penile erythema 14.15 10.97 5 65603 182 110523509
Pelvic organ injury 14.10 10.97 3 65605 14 110523677
Prostatic operation 14.05 10.97 6 65602 365 110523326
Breast enlargement 14.01 10.97 10 65598 1679 110522012
Mobility decreased 13.98 10.97 83 65525 237339 110286352
Internal haemorrhage 13.98 10.97 23 65585 10048 110513643
Paternal drugs affecting foetus 13.93 10.97 3 65605 15 110523676
Alpha 2 globulin decreased 13.93 10.97 3 65605 15 110523676
Testicular microlithiasis 13.93 10.97 3 65605 15 110523676
Sex hormone binding globulin decreased 13.93 10.97 3 65605 15 110523676
Anti-androgen withdrawal syndrome 13.93 10.97 3 65605 15 110523676
Dehydration 13.86 10.97 238 65370 279273 110244418
Bladder transitional cell carcinoma recurrent 13.85 10.97 5 65603 194 110523497
Tendon calcification 13.82 10.97 5 65603 195 110523496
Arteriosclerosis 13.77 10.97 39 65569 24728 110498963
Free androgen index decreased 13.76 10.97 3 65605 16 110523675
Otosalpingitis 13.76 10.97 3 65605 16 110523675
Dermatitis artefacta 13.74 10.97 4 65604 77 110523614
Nipple disorder 13.72 10.97 6 65602 387 110523304
Urogenital haemorrhage 13.68 10.97 8 65600 956 110522735
Mixed anxiety and depressive disorder 13.67 10.97 7 65601 644 110523047
Benign tumour excision 13.64 10.97 4 65604 79 110523612
Blood oestrogen increased 13.59 10.97 5 65603 205 110523486
Retrograde ejaculation 13.46 10.97 6 65602 405 110523286
Tremor 13.43 10.97 181 65427 202051 110321640
Lung disorder 13.42 10.97 58 65550 179989 110343702
Anti factor Xa activity decreased 13.33 10.97 3 65605 19 110523672
Withdrawal hypertension 13.30 10.97 6 65602 417 110523274
Urticaria 13.26 10.97 123 65485 318734 110204957
Hypotrichosis 13.25 10.97 5 65603 220 110523471
Phobia 13.19 10.97 6 65602 425 110523266
Myxoedema coma 13.17 10.97 7 65601 695 110522996
Cytomegalovirus infection 13.14 10.97 8 65600 54436 110469255
Rib fracture 13.12 10.97 47 65561 33723 110489968
Peyronie's disease 13.07 10.97 3 65605 21 110523670
Glycosylated haemoglobin increased 12.94 10.97 37 65571 23582 110500109
Vitreous floaters 12.87 10.97 21 65587 9113 110514578
Febrile neutropenia 12.82 10.97 123 65485 316644 110207047
Therapy non-responder 12.77 10.97 49 65559 157258 110366433
Aggression 12.72 10.97 69 65539 59141 110464550
Strangury 12.72 10.97 5 65603 246 110523445
Fat tissue increased 12.65 10.97 8 65600 1100 110522591
Borderline personality disorder 12.62 10.97 8 65600 1104 110522587
Cardiac disorder 12.61 10.97 83 65525 76197 110447494
Premature ageing 12.60 10.97 4 65604 104 110523587
Epididymitis 12.59 10.97 11 65597 2473 110521218
Acute myocardial infarction 12.57 10.97 89 65519 83688 110440003
Parkinson's disease 12.51 10.97 9 65599 1530 110522161
Testicular germ cell tumour mixed 12.50 10.97 3 65605 26 110523665
Ocular myasthenia 12.50 10.97 7 65601 771 110522920
Urinary tract infection 12.48 10.97 267 65341 326015 110197676
Myosclerosis 12.42 10.97 5 65603 262 110523429
Epistaxis 12.37 10.97 125 65483 130247 110393444
Diverticulum 12.34 10.97 28 65580 15498 110508193
Genital disorder 12.30 10.97 3 65605 28 110523663
Intentional overdose 12.28 10.97 39 65569 132462 110391229
Penile swelling 12.26 10.97 7 65601 799 110522892
Treatment delayed 12.26 10.97 6 65602 501 110523190
Gingivitis 12.25 10.97 22 65586 10309 110513382
Viral acanthoma 12.21 10.97 3 65605 29 110523662
Basosquamous carcinoma 12.19 10.97 4 65604 116 110523575
Peripheral coldness 12.12 10.97 31 65577 18509 110505182
Urinary incontinence 12.09 10.97 59 65549 48528 110475163
Pulmonary vasculitis 11.96 10.97 17 65591 6543 110517148
Oedema peripheral 11.95 10.97 267 65341 328393 110195298
Iron metabolism disorder 11.93 10.97 4 65604 124 110523567
Haematoma 11.80 10.97 67 65541 58409 110465282
Respiratory disorder 11.79 10.97 15 65593 71367 110452324
Feminisation acquired 11.78 10.97 3 65605 34 110523657
Peritoneal neoplasm 11.75 10.97 4 65604 130 110523561
Dyspnoea 11.74 10.97 784 64824 1106088 109417603
Mycotic allergy 11.70 10.97 16 65592 5938 110517753
Leukopenia 11.66 10.97 47 65561 148744 110374947
Ear infection 11.64 10.97 12 65596 62720 110460971
Anaemia 11.63 10.97 415 65193 546671 109977020
Dust allergy 11.61 10.97 16 65592 5985 110517706
Taste disorder 11.58 10.97 13 65595 65374 110458317
Meibomian gland dysfunction 11.58 10.97 5 65603 313 110523378
Loss of consciousness 11.55 10.97 172 65436 196134 110327557
Disseminated intravascular coagulation 11.55 10.97 5 65603 41281 110482410
Mesenteric vascular insufficiency 11.47 10.97 4 65604 140 110523551
Scrotal pain 11.47 10.97 6 65602 577 110523114
Hypohidrosis 11.46 10.97 5 65603 321 110523370
Knee arthroplasty 11.41 10.97 13 65595 64935 110458756
Colour blindness 11.40 10.97 6 65602 584 110523107
Dementia 11.39 10.97 43 65565 31630 110492061
Liver function test increased 11.39 10.97 22 65586 88526 110435165
Product dispensing error 11.39 10.97 28 65580 16317 110507374
Posterior reversible encephalopathy syndrome 11.39 10.97 3 65605 33858 110489833
Heparin-induced thrombocytopenia test positive 11.34 10.97 4 65604 145 110523546
Blood testosterone abnormal 11.30 10.97 5 65603 332 110523359
Genital rash 11.29 10.97 8 65600 1327 110522364
Upper respiratory tract infection 11.26 10.97 40 65568 131288 110392403
Sensory disturbance 11.25 10.97 29 65579 17400 110506291
Nasal discomfort 11.24 10.97 16 65592 6165 110517526
Lower gastrointestinal haemorrhage 11.16 10.97 30 65578 18456 110505235
Abnormal loss of weight 11.10 10.97 21 65587 10236 110513455
Infusion site induration 11.08 10.97 8 65600 1368 110522323
Blood testosterone free decreased 11.06 10.97 3 65605 44 110523647
Colitis ulcerative 11.05 10.97 18 65590 77345 110446346
Cortisol increased 10.99 10.97 6 65602 628 110523063
Zinc deficiency 10.99 10.97 5 65603 354 110523337
Anticoagulation drug level increased 10.97 10.97 7 65601 978 110522713

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX10 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC G04CA51 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
ATC G04CA55 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
ATC G04CB01 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Testosterone-5-alpha reductase inhibitors
ATC G04CB51 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Testosterone-5-alpha reductase inhibitors
FDA MoA N0000000126 5-alpha Reductase Inhibitors
CHEBI has role CHEBI:35497 androgen antagonist
CHEBI has role CHEBI:50781 EC 1.3.1.22 [3-oxo-5ฮฑ-steroid 4-dehydrogenase (NADP<small><sup>+</small></sup>)] inhibitor
CHEBI has role CHEBI:59844 antihyperplasia drug
FDA EPC N0000175836 5-alpha Reductase Inhibitor
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D006727 Hormone Antagonists
MeSH PA D058891 5-alpha Reductase Inhibitors
MeSH PA D064804 Urological Agents
MeSH PA D065088 Steroid Synthesis Inhibitors

Related Drugs by ATC class:

D11AX Other dermatologicals 20 drugs
aminobenzoic acidbrimonidinecaffeinecalcium gluconatedeoxycholic aciddiclofenaceflornithinegamolenic acidhydrogen peroxidehydroquinoneivermectinlithium succinate show all 20 →
G04CA Alpha-adrenoreceptor antagonists 8 drugs
alfuzosindoxazosindutasteridesilodosinsolifenacintadalafiltamsulosinterazosin
G04CB Testosterone-5-alpha reductase inhibitors 2 drugs
dutasteridetadalafil

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Benign prostatic hyperplasia indication 266569009
Male Patterned Baldness indication
Hidradenitis suppurativa off-label use 59393003 DOID:2280
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
High-Grade Prostate Cancer contraindication
Breast Carcinoma in Males contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.26 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Enzyme INHIBITOR IC50 8.26 WOMBAT-PK DRUG LABEL
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Enzyme INHIBITOR IC50 7.58 WOMBAT-PK DRUG LABEL
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Enzyme Ki 4.96 CHEMBL
Cytochrome P450 2C9 Enzyme IC50 5.70 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Enzyme Ki 8.17 CHEMBL
Steroid 5-alpha-reductase Enzyme Ki 7.26 CHEMBL
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Enzyme IC50 9.55 CHEMBL

External reference:

IDSource
4020167 VUID
N0000148118 NUI
D00321 KEGG_DRUG
4020167 VANDF
C0060389 UMLSCUI
CHEBI:5062 CHEBI
FIT PDB_CHEM_ID
CHEMBL710 ChEMBL_ID
DB01216 DRUGBANK_ID
D018120 MESH_DESCRIPTOR_UI
57363 PUBCHEM_CID
6818 IUPHAR_LIGAND_ID
6539 INN_ID
57GNO57U7G UNII
219462 RXNORM
11509 MMSL
4728 MMSL
82773 MMSL
d00563 MMSL
003665 NDDF
109035006 SNOMEDCT_US
386963006 SNOMEDCT_US
57GNO57U7G INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7355 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8562 TABLET 5 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6830 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 16729-089 TABLET, FILM COATED 1 mg ORAL ANDA 28 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 16729-090 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 17856-0090 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 31722-525 TABLET, FILM COATED 5 mg ORAL ANDA 22 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 31722-525 TABLET, FILM COATED 5 mg ORAL ANDA 22 sections
Finasteride Human Prescription Drug Label 1 31722-526 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 33261-833 TABLET 5 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 35573-400 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 43598-303 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 43598-390 TABLET, FILM COATED 1 mg ORAL ANDA 25 sections
Finasteride Human Prescription Drug Label 1 47335-714 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 50090-1936 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3942 TABLET, FILM COATED 1 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 50090-4648 TABLET, COATED 1 mg ORAL ANDA 25 sections
Finasteride Human Prescription Drug Label 1 50090-4697 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 50090-6940 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 50090-6941 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 50090-7086 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 50090-7228 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 50268-314 TABLET, FILM COATED 5 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 50436-0089 TABLET, FILM COATED 1 mg ORAL ANDA 27 sections
Finasteride Human Prescription Drug Label 1 50436-0455 TABLET, COATED 1 mg ORAL ANDA 25 sections
Finasteride Human Prescription Drug Label 1 50436-0927 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
PROPECIA HUMAN PRESCRIPTION DRUG LABEL 1 54868-4120 TABLET, FILM COATED 1 mg ORAL NDA 29 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 54868-5636 TABLET, FILM COATED 5 mg ORAL ANDA 14 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 55111-171 TABLET, FILM COATED 1 mg ORAL ANDA 26 sections
Finasteride HUMAN PRESCRIPTION DRUG LABEL 1 55111-172 TABLET 5 mg ORAL ANDA 26 sections