Stem definition | Drug id | CAS RN |
---|---|---|
antihypertensive substances, prazosin derivatives | 2562 | 106133-20-4 |
Dose | Unit | Route |
---|---|---|
0.40 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 8.70 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.03 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.21 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.62 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 6.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
April 15, 1997 | FDA | BOEHRINGER INGELHEIM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Nephrolithiasis | 168.39 | 14.70 | 88 | 7334 | 34605 | 50563097 |
Urinary tract infection | 87.92 | 14.70 | 134 | 7288 | 223886 | 50373816 |
Multiple sclerosis relapse | 70.62 | 14.70 | 55 | 7367 | 42909 | 50554793 |
Residual urine volume increased | 44.38 | 14.70 | 7 | 7415 | 24 | 50597678 |
Urinary retention | 44.04 | 14.70 | 34 | 7388 | 26156 | 50571546 |
Ligament pain | 37.31 | 14.70 | 8 | 7414 | 182 | 50597520 |
Renal colic | 34.59 | 14.70 | 11 | 7411 | 1198 | 50596504 |
Respiratory tract inflammation | 33.68 | 14.70 | 9 | 7413 | 531 | 50597171 |
Multiple sclerosis | 31.00 | 14.70 | 25 | 7397 | 20468 | 50577234 |
Drug ineffective | 29.41 | 14.70 | 47 | 7375 | 819286 | 49778416 |
Pertussis | 27.69 | 14.70 | 8 | 7414 | 630 | 50597072 |
Progressive multifocal leukoencephalopathy | 26.38 | 14.70 | 18 | 7404 | 11439 | 50586263 |
Sinus pain | 24.40 | 14.70 | 10 | 7412 | 2251 | 50595451 |
Disorganised speech | 24.21 | 14.70 | 8 | 7414 | 983 | 50596719 |
Urinary tract obstruction | 23.29 | 14.70 | 9 | 7413 | 1739 | 50595963 |
Renal stone removal | 22.83 | 14.70 | 5 | 7417 | 126 | 50597576 |
Immune reconstitution inflammatory syndrome | 21.18 | 14.70 | 12 | 7410 | 5504 | 50592198 |
Hydronephrosis | 21.06 | 14.70 | 14 | 7408 | 8527 | 50589175 |
Chorioretinitis | 20.88 | 14.70 | 6 | 7416 | 463 | 50597239 |
Flank pain | 19.83 | 14.70 | 16 | 7406 | 13099 | 50584603 |
Iris disorder | 19.54 | 14.70 | 4 | 7418 | 72 | 50597630 |
Rheumatoid arthritis | 17.73 | 14.70 | 4 | 7418 | 202546 | 50395156 |
Fall | 16.92 | 14.70 | 95 | 7327 | 334837 | 50262865 |
Central nervous system stimulation | 16.79 | 14.70 | 3 | 7419 | 25 | 50597677 |
Erythropenia | 16.51 | 14.70 | 4 | 7418 | 159 | 50597543 |
Heparin-induced thrombocytopenia | 16.24 | 14.70 | 9 | 7413 | 3956 | 50593746 |
Hypertensive nephropathy | 16.23 | 14.70 | 5 | 7417 | 491 | 50597211 |
Product use issue | 15.78 | 14.70 | 53 | 7369 | 149422 | 50448280 |
Tendon pain | 15.70 | 14.70 | 8 | 7414 | 2970 | 50594732 |
Orthopnoea | 15.68 | 14.70 | 10 | 7412 | 5679 | 50592023 |
Central nervous system lesion | 15.25 | 14.70 | 12 | 7410 | 9477 | 50588225 |
Product use in unapproved indication | 14.91 | 14.70 | 44 | 7378 | 115775 | 50481927 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Iris disorder | 735.54 | 10.68 | 197 | 151041 | 145 | 29423144 |
Fall | 354.07 | 10.68 | 1814 | 149424 | 175364 | 29247925 |
Dizziness | 337.48 | 10.68 | 1881 | 149357 | 187803 | 29235486 |
Urinary retention | 324.55 | 10.68 | 584 | 150654 | 31314 | 29391975 |
Cataract operation complication | 248.51 | 10.68 | 71 | 151167 | 85 | 29423204 |
Orthostatic hypotension | 242.62 | 10.68 | 424 | 150814 | 22205 | 29401084 |
Drug abuse | 224.42 | 10.68 | 65 | 151173 | 79818 | 29343471 |
Iridocele | 222.06 | 10.68 | 57 | 151181 | 27 | 29423262 |
Syncope | 215.07 | 10.68 | 905 | 150333 | 80466 | 29342823 |
Toxicity to various agents | 206.67 | 10.68 | 357 | 150881 | 173304 | 29249985 |
Urinary tract infection | 196.87 | 10.68 | 812 | 150426 | 71542 | 29351747 |
Procedural complication | 171.41 | 10.68 | 152 | 151086 | 3908 | 29419381 |
Dysuria | 157.48 | 10.68 | 352 | 150886 | 22088 | 29401201 |
Floppy iris syndrome | 149.33 | 10.68 | 57 | 151181 | 250 | 29423039 |
Idiopathic pulmonary fibrosis | 144.61 | 10.68 | 124 | 151114 | 3044 | 29420245 |
Completed suicide | 131.25 | 10.68 | 161 | 151077 | 90085 | 29333204 |
Product prescribing error | 123.91 | 10.68 | 280 | 150958 | 17696 | 29405593 |
Pollakiuria | 120.53 | 10.68 | 267 | 150971 | 16649 | 29406640 |
Benign prostatic hyperplasia | 114.71 | 10.68 | 211 | 151027 | 11499 | 29411790 |
Fatigue | 108.08 | 10.68 | 2243 | 148995 | 314578 | 29108711 |
Drug ineffective | 107.22 | 10.68 | 1266 | 149972 | 361904 | 29061385 |
Off label use | 101.33 | 10.68 | 1017 | 150221 | 299783 | 29123506 |
Nocturia | 99.26 | 10.68 | 164 | 151074 | 8198 | 29415091 |
Multiple organ dysfunction syndrome | 96.68 | 10.68 | 108 | 151130 | 63008 | 29360281 |
Micturition urgency | 89.45 | 10.68 | 121 | 151117 | 5052 | 29418237 |
Retrograde ejaculation | 88.78 | 10.68 | 40 | 151198 | 286 | 29423003 |
Urinary incontinence | 86.26 | 10.68 | 231 | 151007 | 16250 | 29407039 |
Asthenia | 83.67 | 10.68 | 1555 | 149683 | 213695 | 29209594 |
Atrial fibrillation | 82.28 | 10.68 | 864 | 150374 | 104782 | 29318507 |
Drug resistance | 81.21 | 10.68 | 8 | 151230 | 21532 | 29401757 |
Febrile neutropenia | 78.93 | 10.68 | 301 | 150937 | 111939 | 29311350 |
Haematuria | 78.23 | 10.68 | 438 | 150800 | 43701 | 29379588 |
Intentional overdose | 69.39 | 10.68 | 57 | 151181 | 38471 | 29384818 |
Pupillary disorder | 66.84 | 10.68 | 31 | 151207 | 239 | 29423050 |
Hallucination | 66.62 | 10.68 | 424 | 150814 | 44288 | 29379001 |
Presyncope | 66.31 | 10.68 | 207 | 151031 | 15882 | 29407407 |
Treatment failure | 63.66 | 10.68 | 57 | 151181 | 36882 | 29386407 |
Product monitoring error | 58.61 | 10.68 | 70 | 151168 | 2575 | 29420714 |
Balance disorder | 58.27 | 10.68 | 350 | 150888 | 35820 | 29387469 |
Cardio-respiratory arrest | 58.24 | 10.68 | 106 | 151132 | 50495 | 29372794 |
Confusional state | 57.89 | 10.68 | 947 | 150291 | 126930 | 29296359 |
Cytomegalovirus infection | 56.38 | 10.68 | 24 | 151214 | 23191 | 29400098 |
Hypotension | 55.89 | 10.68 | 1344 | 149894 | 193010 | 29230279 |
Prostatomegaly | 54.76 | 10.68 | 91 | 151147 | 4570 | 29418719 |
Urogenital haemorrhage | 54.58 | 10.68 | 33 | 151205 | 457 | 29422832 |
Right atrial hypertrophy | 54.01 | 10.68 | 34 | 151204 | 508 | 29422781 |
Dyspnoea | 53.41 | 10.68 | 2108 | 149130 | 324624 | 29098665 |
Drug dependence | 52.07 | 10.68 | 21 | 151217 | 20960 | 29402329 |
Suicide attempt | 51.52 | 10.68 | 59 | 151179 | 34051 | 29389238 |
Thrombocytopenia | 51.15 | 10.68 | 442 | 150796 | 134381 | 29288908 |
Labelled drug-drug interaction medication error | 50.63 | 10.68 | 157 | 151081 | 12002 | 29411287 |
Prostatic disorder | 50.34 | 10.68 | 68 | 151170 | 2835 | 29420454 |
Abdominal pain lower | 50.26 | 10.68 | 126 | 151112 | 8512 | 29414777 |
General physical health deterioration | 50.03 | 10.68 | 771 | 150467 | 102086 | 29321203 |
Miosis | 49.98 | 10.68 | 120 | 151118 | 7889 | 29415400 |
Urine flow decreased | 49.95 | 10.68 | 43 | 151195 | 1061 | 29422228 |
Leukopenia | 47.05 | 10.68 | 136 | 151102 | 55067 | 29368222 |
Respiratory arrest | 46.79 | 10.68 | 38 | 151200 | 25795 | 29397494 |
Prostatic specific antigen increased | 45.78 | 10.68 | 155 | 151083 | 12409 | 29410880 |
Peripheral swelling | 45.28 | 10.68 | 512 | 150726 | 63227 | 29360062 |
Pyrexia | 44.41 | 10.68 | 1126 | 150112 | 286496 | 29136793 |
Bradycardia | 44.30 | 10.68 | 522 | 150716 | 65107 | 29358182 |
Alanine aminotransferase increased | 42.60 | 10.68 | 202 | 151036 | 70742 | 29352547 |
Ocular procedural complication | 42.25 | 10.68 | 15 | 151223 | 51 | 29423238 |
Constipation | 42.24 | 10.68 | 819 | 150419 | 113341 | 29309948 |
Overdose | 41.35 | 10.68 | 239 | 150999 | 79580 | 29343709 |
Prostate cancer | 41.10 | 10.68 | 247 | 150991 | 25280 | 29398009 |
Cardiac arrest | 40.83 | 10.68 | 263 | 150975 | 85328 | 29337961 |
Memory impairment | 38.79 | 10.68 | 319 | 150919 | 36151 | 29387138 |
Hypertonic bladder | 38.11 | 10.68 | 42 | 151196 | 1414 | 29421875 |
Plasma cell myeloma | 37.53 | 10.68 | 321 | 150917 | 36794 | 29386495 |
Aortic valve stenosis | 37.19 | 10.68 | 51 | 151187 | 2157 | 29421132 |
Ejaculation failure | 37.01 | 10.68 | 31 | 151207 | 736 | 29422553 |
Needle fatigue | 36.98 | 10.68 | 28 | 151210 | 572 | 29422717 |
Bronchial secretion retention | 36.85 | 10.68 | 37 | 151201 | 1116 | 29422173 |
Bone marrow failure | 36.76 | 10.68 | 52 | 151186 | 27397 | 29395892 |
Right ventricular hypertrophy | 36.64 | 10.68 | 37 | 151201 | 1124 | 29422165 |
Neutropenia | 36.40 | 10.68 | 465 | 150773 | 131246 | 29292043 |
Hepatic failure | 36.26 | 10.68 | 66 | 151172 | 31446 | 29391843 |
Bladder disorder | 36.16 | 10.68 | 57 | 151181 | 2737 | 29420552 |
Cataract operation | 36.04 | 10.68 | 36 | 151202 | 1079 | 29422210 |
Drug reaction with eosinophilia and systemic symptoms | 35.56 | 10.68 | 55 | 151183 | 27937 | 29395352 |
Orbital myositis | 35.56 | 10.68 | 16 | 151222 | 114 | 29423175 |
Pulmonary function test abnormal | 34.94 | 10.68 | 48 | 151190 | 2034 | 29421255 |
Mucosal inflammation | 34.75 | 10.68 | 68 | 151170 | 31527 | 29391762 |
Hospice care | 33.87 | 10.68 | 78 | 151160 | 4990 | 29418299 |
Haematoma | 33.86 | 10.68 | 219 | 151019 | 22993 | 29400296 |
Cystitis | 33.54 | 10.68 | 106 | 151132 | 8186 | 29415103 |
Gait spastic | 33.53 | 10.68 | 28 | 151210 | 662 | 29422627 |
Cataract | 33.18 | 10.68 | 212 | 151026 | 22166 | 29401123 |
Hypoacusis | 33.15 | 10.68 | 154 | 151084 | 14269 | 29409020 |
Bladder spasm | 32.82 | 10.68 | 30 | 151208 | 803 | 29422486 |
Aspergillus infection | 32.80 | 10.68 | 7 | 151231 | 10574 | 29412715 |
Congenital hiatus hernia | 32.62 | 10.68 | 23 | 151215 | 419 | 29422870 |
Myelosuppression | 32.42 | 10.68 | 11 | 151227 | 12216 | 29411073 |
Haematochezia | 32.37 | 10.68 | 310 | 150928 | 36673 | 29386616 |
Bronchial wall thickening | 32.24 | 10.68 | 33 | 151205 | 1019 | 29422270 |
Plasmapheresis | 32.17 | 10.68 | 20 | 151218 | 292 | 29422997 |
Relapsing-remitting multiple sclerosis | 32.09 | 10.68 | 28 | 151210 | 704 | 29422585 |
Full blood count decreased | 31.92 | 10.68 | 164 | 151074 | 15828 | 29407461 |
Hormone receptor positive breast cancer | 31.60 | 10.68 | 10 | 151228 | 21 | 29423268 |
Gait disturbance | 31.59 | 10.68 | 539 | 150699 | 72810 | 29350479 |
Intentional product use issue | 31.12 | 10.68 | 112 | 151126 | 42386 | 29380903 |
Lower urinary tract symptoms | 30.65 | 10.68 | 17 | 151221 | 198 | 29423091 |
Haemophagocytic lymphohistiocytosis | 30.49 | 10.68 | 8 | 151230 | 10496 | 29412793 |
Vitreous loss | 30.39 | 10.68 | 8 | 151230 | 5 | 29423284 |
Coma | 30.21 | 10.68 | 102 | 151136 | 39348 | 29383941 |
Nephrolithiasis | 29.90 | 10.68 | 227 | 151011 | 25107 | 29398182 |
Product substitution issue | 29.83 | 10.68 | 109 | 151129 | 9063 | 29414226 |
Graft versus host disease | 28.59 | 10.68 | 7 | 151231 | 9621 | 29413668 |
Vomiting | 28.54 | 10.68 | 847 | 150391 | 211413 | 29211876 |
Synovitis | 28.52 | 10.68 | 10 | 151228 | 10880 | 29412409 |
Poisoning | 28.27 | 10.68 | 8 | 151230 | 9985 | 29413304 |
Erectile dysfunction | 28.19 | 10.68 | 173 | 151065 | 17836 | 29405453 |
Chronic obstructive pulmonary disease | 28.17 | 10.68 | 327 | 150911 | 40628 | 29382661 |
Wound | 27.87 | 10.68 | 129 | 151109 | 11934 | 29411355 |
Disseminated intravascular coagulation | 27.61 | 10.68 | 37 | 151201 | 19943 | 29403346 |
Contusion | 27.38 | 10.68 | 261 | 150977 | 30834 | 29392455 |
Obstruction | 27.33 | 10.68 | 41 | 151197 | 1885 | 29421404 |
Muscular weakness | 27.09 | 10.68 | 457 | 150781 | 61595 | 29361694 |
Dacryocystitis | 26.98 | 10.68 | 8 | 151230 | 12 | 29423277 |
Hepatic vein dilatation | 26.81 | 10.68 | 16 | 151222 | 216 | 29423073 |
Prostatitis | 26.79 | 10.68 | 68 | 151170 | 4629 | 29418660 |
Seizure | 26.74 | 10.68 | 326 | 150912 | 92797 | 29330492 |
Priapism | 26.67 | 10.68 | 66 | 151172 | 4422 | 29418867 |
Septic shock | 26.49 | 10.68 | 199 | 151039 | 62361 | 29360928 |
Adverse drug reaction | 26.02 | 10.68 | 211 | 151027 | 23809 | 29399480 |
Vertigo | 25.86 | 10.68 | 196 | 151042 | 21665 | 29401624 |
Ascites | 25.83 | 10.68 | 98 | 151140 | 36521 | 29386768 |
Infusion related reaction | 25.72 | 10.68 | 126 | 151112 | 43760 | 29379529 |
Bladder catheterisation | 25.52 | 10.68 | 21 | 151217 | 486 | 29422803 |
Drug intolerance | 25.50 | 10.68 | 144 | 151094 | 48235 | 29375054 |
Pancytopenia | 25.48 | 10.68 | 287 | 150951 | 82881 | 29340408 |
Hot flush | 25.30 | 10.68 | 146 | 151092 | 14724 | 29408565 |
Hepatic cytolysis | 24.92 | 10.68 | 6 | 151232 | 8341 | 29414948 |
Hepatotoxicity | 24.77 | 10.68 | 33 | 151205 | 17834 | 29405455 |
Hepatitis | 24.38 | 10.68 | 43 | 151195 | 20740 | 29402549 |
Atrial septal defect | 24.38 | 10.68 | 3 | 151235 | 6786 | 29416503 |
Head injury | 24.24 | 10.68 | 153 | 151085 | 15928 | 29407361 |
Therapy non-responder | 23.61 | 10.68 | 80 | 151158 | 30831 | 29392458 |
Milk-alkali syndrome | 22.95 | 10.68 | 20 | 151218 | 502 | 29422787 |
Dementia | 22.88 | 10.68 | 119 | 151119 | 11539 | 29411750 |
Muscle spasms | 22.73 | 10.68 | 463 | 150775 | 64619 | 29358670 |
Nipple pain | 22.49 | 10.68 | 21 | 151217 | 578 | 29422711 |
Palpitations | 22.28 | 10.68 | 260 | 150978 | 32344 | 29390945 |
Pneumocystis jirovecii pneumonia | 22.25 | 10.68 | 32 | 151206 | 16747 | 29406542 |
Factitious disorder | 22.16 | 10.68 | 9 | 151229 | 48 | 29423241 |
Prostatic mass | 22.14 | 10.68 | 8 | 151230 | 29 | 29423260 |
C-reactive protein increased | 22.13 | 10.68 | 134 | 151104 | 44129 | 29379160 |
Pancreatitis | 22.06 | 10.68 | 96 | 151142 | 34418 | 29388871 |
Intentional self-injury | 21.74 | 10.68 | 19 | 151219 | 12442 | 29410847 |
Bladder cancer | 21.72 | 10.68 | 106 | 151132 | 10021 | 29413268 |
Product use in unapproved indication | 21.70 | 10.68 | 313 | 150925 | 86562 | 29336727 |
Platypnoea | 21.54 | 10.68 | 8 | 151230 | 32 | 29423257 |
Loss of consciousness | 21.47 | 10.68 | 513 | 150725 | 73543 | 29349746 |
Oedema peripheral | 21.46 | 10.68 | 687 | 150551 | 102870 | 29320419 |
Drug hypersensitivity | 21.37 | 10.68 | 235 | 151003 | 68171 | 29355118 |
Liver palpable | 21.19 | 10.68 | 15 | 151223 | 275 | 29423014 |
Acute hepatic failure | 21.12 | 10.68 | 18 | 151220 | 11934 | 29411355 |
Cornea verticillata | 20.97 | 10.68 | 8 | 151230 | 35 | 29423254 |
Brain oedema | 20.88 | 10.68 | 19 | 151219 | 12201 | 29411088 |
Immune reconstitution inflammatory syndrome | 20.72 | 10.68 | 7 | 151231 | 7795 | 29415494 |
Status epilepticus | 20.66 | 10.68 | 15 | 151223 | 10779 | 29412510 |
Hepatic function abnormal | 20.61 | 10.68 | 117 | 151121 | 39142 | 29384147 |
Back pain | 20.53 | 10.68 | 676 | 150562 | 101608 | 29321681 |
Cytomegalovirus viraemia | 19.96 | 10.68 | 4 | 151234 | 6316 | 29416973 |
Hip fracture | 19.84 | 10.68 | 106 | 151132 | 10386 | 29412903 |
Fractional exhaled nitric oxide increased | 19.82 | 10.68 | 16 | 151222 | 360 | 29422929 |
Idiopathic interstitial pneumonia | 19.70 | 10.68 | 11 | 151227 | 130 | 29423159 |
Cardiogenic shock | 19.66 | 10.68 | 43 | 151195 | 19147 | 29404142 |
Lacunar stroke | 19.48 | 10.68 | 11 | 151227 | 133 | 29423156 |
Blood bilirubin increased | 19.46 | 10.68 | 98 | 151140 | 33795 | 29389494 |
Candida infection | 19.26 | 10.68 | 30 | 151208 | 15195 | 29408094 |
Atrial enlargement | 19.14 | 10.68 | 15 | 151223 | 323 | 29422966 |
Gait inability | 19.14 | 10.68 | 160 | 151078 | 18215 | 29405074 |
Psychotic disorder | 18.94 | 10.68 | 48 | 151190 | 20306 | 29402983 |
Agranulocytosis | 18.91 | 10.68 | 48 | 151190 | 20292 | 29402997 |
Wrong schedule | 18.86 | 10.68 | 11 | 151227 | 142 | 29423147 |
Post micturition dribble | 18.84 | 10.68 | 6 | 151232 | 13 | 29423276 |
Dysgeusia | 18.82 | 10.68 | 188 | 151050 | 22486 | 29400803 |
Aspartate aminotransferase increased | 18.73 | 10.68 | 205 | 151033 | 59520 | 29363769 |
Stomal hernia | 18.66 | 10.68 | 11 | 151227 | 145 | 29423144 |
Dizziness postural | 18.49 | 10.68 | 65 | 151173 | 5302 | 29417987 |
Drug eruption | 18.43 | 10.68 | 36 | 151202 | 16705 | 29406584 |
Sleep apnoea syndrome | 18.20 | 10.68 | 153 | 151085 | 17446 | 29405843 |
Urinary tract obstruction | 18.05 | 10.68 | 47 | 151191 | 3250 | 29420039 |
Diabetic neuropathy | 18.04 | 10.68 | 51 | 151187 | 3702 | 29419587 |
Urosepsis | 17.95 | 10.68 | 105 | 151133 | 10641 | 29412648 |
Dyspnoea exertional | 17.88 | 10.68 | 274 | 150964 | 36216 | 29387073 |
Perineal pain | 17.83 | 10.68 | 21 | 151217 | 761 | 29422528 |
Intentional product misuse | 17.82 | 10.68 | 104 | 151134 | 34557 | 29388732 |
Blood creatine phosphokinase increased | 17.82 | 10.68 | 128 | 151110 | 40516 | 29382773 |
Haematotoxicity | 17.81 | 10.68 | 6 | 151232 | 6693 | 29416596 |
Hepatomegaly | 17.76 | 10.68 | 13 | 151225 | 9304 | 29413985 |
Subdural haematoma | 17.68 | 10.68 | 156 | 151082 | 18037 | 29405252 |
Muscle spasticity | 17.57 | 10.68 | 60 | 151178 | 4823 | 29418466 |
Stress | 17.54 | 10.68 | 54 | 151184 | 21436 | 29401853 |
Iris haemorrhage | 17.49 | 10.68 | 5 | 151233 | 6 | 29423283 |
Rectal prolapse | 17.49 | 10.68 | 13 | 151225 | 258 | 29423031 |
Ventricular fibrillation | 17.47 | 10.68 | 34 | 151204 | 15799 | 29407490 |
Pathogen resistance | 17.28 | 10.68 | 10 | 151228 | 8106 | 29415183 |
Bladder neck obstruction | 17.15 | 10.68 | 10 | 151228 | 129 | 29423160 |
Haematospermia | 17.05 | 10.68 | 14 | 151224 | 323 | 29422966 |
Therapy partial responder | 17.04 | 10.68 | 3 | 151235 | 5196 | 29418093 |
Intestinal haemorrhage | 16.96 | 10.68 | 44 | 151194 | 3035 | 29420254 |
Serum ferritin abnormal | 16.96 | 10.68 | 12 | 151226 | 220 | 29423069 |
Myocardial infarction | 16.88 | 10.68 | 432 | 150806 | 109864 | 29313425 |
Full blood count abnormal | 16.87 | 10.68 | 133 | 151105 | 14880 | 29408409 |
Dry mouth | 16.84 | 10.68 | 178 | 151060 | 21606 | 29401683 |
Renal failure | 16.72 | 10.68 | 470 | 150768 | 118129 | 29305160 |
Thrombotic microangiopathy | 16.70 | 10.68 | 12 | 151226 | 8669 | 29414620 |
Dacryostenosis acquired | 16.61 | 10.68 | 11 | 151227 | 180 | 29423109 |
Resting tremor | 16.50 | 10.68 | 18 | 151220 | 599 | 29422690 |
Bladder discomfort | 16.44 | 10.68 | 9 | 151229 | 102 | 29423187 |
Hyponatraemic syndrome | 16.41 | 10.68 | 11 | 151227 | 184 | 29423105 |
Aplastic anaemia | 16.35 | 10.68 | 9 | 151229 | 7501 | 29415788 |
Akathisia | 16.32 | 10.68 | 7 | 151231 | 6735 | 29416554 |
Post transplant lymphoproliferative disorder | 16.30 | 10.68 | 4 | 151234 | 5489 | 29417800 |
Peritonitis | 16.22 | 10.68 | 32 | 151206 | 14792 | 29408497 |
Phaeochromocytoma malignant | 16.20 | 10.68 | 8 | 151230 | 72 | 29423217 |
Arteriovenous fistula | 16.16 | 10.68 | 19 | 151219 | 687 | 29422602 |
Puncture site haematoma | 16.08 | 10.68 | 10 | 151228 | 146 | 29423143 |
Iris atrophy | 16.01 | 10.68 | 8 | 151230 | 74 | 29423215 |
Tongue dry | 16.00 | 10.68 | 11 | 151227 | 192 | 29423097 |
Colitis | 15.93 | 10.68 | 94 | 151144 | 31154 | 29392135 |
Bronchopulmonary aspergillosis | 15.92 | 10.68 | 24 | 151214 | 12320 | 29410969 |
Genital swelling | 15.91 | 10.68 | 10 | 151228 | 149 | 29423140 |
Breast tenderness | 15.86 | 10.68 | 19 | 151219 | 701 | 29422588 |
Urinary hesitation | 15.84 | 10.68 | 35 | 151203 | 2178 | 29421111 |
Transaminases increased | 15.75 | 10.68 | 61 | 151177 | 22601 | 29400688 |
Narrow anterior chamber angle | 15.71 | 10.68 | 9 | 151229 | 112 | 29423177 |
Herpes simplex | 15.65 | 10.68 | 3 | 151235 | 4887 | 29418402 |
Cytokine release syndrome | 15.52 | 10.68 | 27 | 151211 | 13092 | 29410197 |
Diastolic dysfunction | 15.48 | 10.68 | 59 | 151179 | 5005 | 29418284 |
Burning feet syndrome | 15.47 | 10.68 | 8 | 151230 | 80 | 29423209 |
Bladder outlet obstruction | 15.46 | 10.68 | 10 | 151228 | 157 | 29423132 |
Blood urine present | 15.45 | 10.68 | 94 | 151144 | 9661 | 29413628 |
Cystitis haemorrhagic | 15.43 | 10.68 | 3 | 151235 | 4839 | 29418450 |
Tubulointerstitial nephritis | 15.36 | 10.68 | 43 | 151195 | 17600 | 29405689 |
Posterior reversible encephalopathy syndrome | 15.28 | 10.68 | 14 | 151224 | 8962 | 29414327 |
Flatulence | 15.27 | 10.68 | 148 | 151090 | 17561 | 29405728 |
Mydriasis | 15.24 | 10.68 | 6 | 151232 | 6079 | 29417210 |
Inferior vena cava dilatation | 15.14 | 10.68 | 18 | 151220 | 659 | 29422630 |
Testicular swelling | 15.02 | 10.68 | 25 | 151213 | 1257 | 29422032 |
Intervertebral disc degeneration | 15.01 | 10.68 | 60 | 151178 | 5204 | 29418085 |
Lymphopenia | 14.99 | 10.68 | 29 | 151209 | 13504 | 29409785 |
Prostatic obstruction | 14.93 | 10.68 | 9 | 151229 | 124 | 29423165 |
Device dislocation | 14.89 | 10.68 | 54 | 151184 | 4473 | 29418816 |
Periorbital haematoma | 14.86 | 10.68 | 13 | 151225 | 328 | 29422961 |
Prostatic operation | 14.83 | 10.68 | 13 | 151225 | 329 | 29422960 |
BK virus infection | 14.83 | 10.68 | 3 | 151235 | 4704 | 29418585 |
Paraplegia | 14.78 | 10.68 | 37 | 151201 | 2497 | 29420792 |
Nephropathy toxic | 14.78 | 10.68 | 20 | 151218 | 10736 | 29412553 |
Suprapubic pain | 14.57 | 10.68 | 13 | 151225 | 337 | 29422952 |
Acute respiratory distress syndrome | 14.53 | 10.68 | 64 | 151174 | 22871 | 29400418 |
Disease recurrence | 14.45 | 10.68 | 38 | 151200 | 15876 | 29407413 |
Faeces discoloured | 14.30 | 10.68 | 117 | 151121 | 13234 | 29410055 |
Subdural hygroma | 14.25 | 10.68 | 12 | 151226 | 287 | 29423002 |
Benign gastrointestinal neoplasm | 14.21 | 10.68 | 9 | 151229 | 136 | 29423153 |
Respiratory distress | 14.12 | 10.68 | 101 | 151137 | 32005 | 29391284 |
Taste disorder | 14.08 | 10.68 | 55 | 151183 | 4721 | 29418568 |
Extrapyramidal disorder | 14.03 | 10.68 | 21 | 151217 | 10810 | 29412479 |
Guillain-Barre syndrome | 13.91 | 10.68 | 57 | 151181 | 5001 | 29418288 |
Tuberculosis | 13.77 | 10.68 | 10 | 151228 | 7186 | 29416103 |
Blood glucose fluctuation | 13.66 | 10.68 | 45 | 151193 | 3552 | 29419737 |
Bladder dysfunction | 13.55 | 10.68 | 12 | 151226 | 308 | 29422981 |
Umbilical hernia | 13.53 | 10.68 | 46 | 151192 | 3689 | 29419600 |
Sepsis | 13.53 | 10.68 | 594 | 150644 | 142088 | 29281201 |
Transient ischaemic attack | 13.50 | 10.68 | 180 | 151058 | 23090 | 29400199 |
Acquired haemophilia | 13.49 | 10.68 | 19 | 151219 | 824 | 29422465 |
Blood pressure systolic | 13.49 | 10.68 | 4 | 151234 | 6 | 29423283 |
Neutrophil count decreased | 13.47 | 10.68 | 150 | 151088 | 43417 | 29379872 |
Bronchiectasis | 13.47 | 10.68 | 68 | 151170 | 6517 | 29416772 |
Oesophageal rupture | 13.45 | 10.68 | 13 | 151225 | 374 | 29422915 |
Ageusia | 13.45 | 10.68 | 85 | 151153 | 8853 | 29414436 |
Arteriosclerotic gangrene | 13.37 | 10.68 | 7 | 151231 | 72 | 29423217 |
Granulocytopenia | 13.32 | 10.68 | 7 | 151231 | 5987 | 29417302 |
Product use issue | 13.32 | 10.68 | 184 | 151054 | 51260 | 29372029 |
Aortic stenosis | 13.28 | 10.68 | 47 | 151191 | 3847 | 29419442 |
Ventricular enlargement | 13.22 | 10.68 | 14 | 151224 | 450 | 29422839 |
Pulmonary tuberculosis | 13.08 | 10.68 | 3 | 151235 | 4312 | 29418977 |
Klebsiella infection | 13.07 | 10.68 | 11 | 151227 | 7338 | 29415951 |
Vena cava injury | 13.05 | 10.68 | 10 | 151228 | 208 | 29423081 |
Cardiotoxicity | 13.05 | 10.68 | 4 | 151234 | 4740 | 29418549 |
Gout | 12.98 | 10.68 | 138 | 151100 | 16773 | 29406516 |
Renal cyst haemorrhage | 12.95 | 10.68 | 13 | 151225 | 392 | 29422897 |
Intraductal papillary mucinous neoplasm | 12.92 | 10.68 | 12 | 151226 | 328 | 29422961 |
Dental restoration failure | 12.91 | 10.68 | 5 | 151233 | 23 | 29423266 |
Femoral artery aneurysm | 12.91 | 10.68 | 9 | 151229 | 161 | 29423128 |
Drug ineffective for unapproved indication | 12.86 | 10.68 | 34 | 151204 | 14180 | 29409109 |
Renal haematoma | 12.85 | 10.68 | 14 | 151224 | 465 | 29422824 |
Vertigo CNS origin | 12.84 | 10.68 | 3 | 151235 | 0 | 29423289 |
Iris injury | 12.84 | 10.68 | 3 | 151235 | 0 | 29423289 |
Macular degeneration | 12.84 | 10.68 | 29 | 151209 | 1831 | 29421458 |
Diarrhoea | 12.80 | 10.68 | 1913 | 149325 | 330785 | 29092504 |
Venoocclusive liver disease | 12.74 | 10.68 | 10 | 151228 | 6907 | 29416382 |
Hepatic enzyme increased | 12.70 | 10.68 | 111 | 151127 | 33688 | 29389601 |
Systemic infection | 12.59 | 10.68 | 31 | 151207 | 2070 | 29421219 |
Pharyngeal cancer | 12.57 | 10.68 | 5 | 151233 | 25 | 29423264 |
Hydronephrosis | 12.51 | 10.68 | 82 | 151156 | 8648 | 29414641 |
Radiation inflammation | 12.50 | 10.68 | 10 | 151228 | 222 | 29423067 |
Respiratory depression | 12.50 | 10.68 | 32 | 151206 | 13491 | 29409798 |
SARS-CoV-2 antibody test positive | 12.47 | 10.68 | 10 | 151228 | 223 | 29423066 |
Injection site pain | 12.44 | 10.68 | 106 | 151132 | 32340 | 29390949 |
Monoparesis | 12.40 | 10.68 | 29 | 151209 | 1874 | 29421415 |
Aggression | 12.37 | 10.68 | 119 | 151119 | 35422 | 29387867 |
Cardiac disorder | 12.31 | 10.68 | 263 | 150975 | 37000 | 29386289 |
Invasive ductal breast carcinoma | 12.16 | 10.68 | 4 | 151234 | 10 | 29423279 |
Choroidal detachment | 12.14 | 10.68 | 12 | 151226 | 355 | 29422934 |
Prostate cancer metastatic | 12.14 | 10.68 | 54 | 151184 | 4912 | 29418377 |
Obstructive airways disorder | 12.05 | 10.68 | 97 | 151141 | 10919 | 29412370 |
Hyperammonaemia | 12.02 | 10.68 | 7 | 151231 | 5656 | 29417633 |
Tendon discomfort | 11.95 | 10.68 | 10 | 151228 | 237 | 29423052 |
Accidental exposure to product | 11.94 | 10.68 | 23 | 151215 | 10730 | 29412559 |
Toxic epidermal necrolysis | 11.90 | 10.68 | 50 | 151188 | 18103 | 29405186 |
Wound haematoma | 11.87 | 10.68 | 6 | 151232 | 57 | 29423232 |
Urinary bladder haemorrhage | 11.85 | 10.68 | 26 | 151212 | 1610 | 29421679 |
Kidney transplant rejection | 11.84 | 10.68 | 11 | 151227 | 6994 | 29416295 |
Stomatitis | 11.78 | 10.68 | 127 | 151111 | 36986 | 29386303 |
Inadequate osteointegration | 11.64 | 10.68 | 4 | 151234 | 12 | 29423277 |
Diabetes mellitus | 11.59 | 10.68 | 139 | 151099 | 39692 | 29383597 |
Drug level increased | 11.55 | 10.68 | 53 | 151185 | 18734 | 29404555 |
Prostatism | 11.41 | 10.68 | 10 | 151228 | 253 | 29423036 |
Liver disorder | 11.39 | 10.68 | 89 | 151149 | 27660 | 29395629 |
Malignant neoplasm progression | 11.37 | 10.68 | 289 | 150949 | 73570 | 29349719 |
Mouth swelling | 11.36 | 10.68 | 25 | 151213 | 1551 | 29421738 |
Skin laceration | 11.35 | 10.68 | 96 | 151142 | 10966 | 29412323 |
Suicidal ideation | 11.34 | 10.68 | 118 | 151120 | 34598 | 29388691 |
Micturition disorder | 11.34 | 10.68 | 28 | 151210 | 1873 | 29421416 |
Dysstasia | 11.33 | 10.68 | 92 | 151146 | 10382 | 29412907 |
Anal incontinence | 11.28 | 10.68 | 65 | 151173 | 6550 | 29416739 |
Circadian rhythm sleep disorder | 11.28 | 10.68 | 12 | 151226 | 388 | 29422901 |
Faecaloma | 11.28 | 10.68 | 47 | 151191 | 4155 | 29419134 |
Inflammation | 11.26 | 10.68 | 69 | 151169 | 22659 | 29400630 |
Wound haemorrhage | 11.19 | 10.68 | 27 | 151211 | 1780 | 29421509 |
Bladder pain | 11.17 | 10.68 | 13 | 151225 | 465 | 29422824 |
Metabolic acidosis | 11.12 | 10.68 | 131 | 151107 | 37531 | 29385758 |
Respiratory failure | 11.01 | 10.68 | 396 | 150842 | 96735 | 29326554 |
Stoma complication | 10.99 | 10.68 | 9 | 151229 | 207 | 29423082 |
Alveolar bone resorption | 10.97 | 10.68 | 4 | 151234 | 15 | 29423274 |
Blood chloride abnormal | 10.97 | 10.68 | 4 | 151234 | 15 | 29423274 |
Lichen sclerosus | 10.97 | 10.68 | 4 | 151234 | 15 | 29423274 |
Transplant rejection | 10.86 | 10.68 | 19 | 151219 | 9193 | 29414096 |
Rib fracture | 10.82 | 10.68 | 106 | 151132 | 12612 | 29410677 |
Food aversion | 10.82 | 10.68 | 11 | 151227 | 337 | 29422952 |
Food refusal | 10.80 | 10.68 | 8 | 151230 | 158 | 29423131 |
Anorectal operation | 10.78 | 10.68 | 3 | 151235 | 3 | 29423286 |
Sperm concentration zero | 10.78 | 10.68 | 3 | 151235 | 3 | 29423286 |
Inappropriate antidiuretic hormone secretion | 10.76 | 10.68 | 94 | 151144 | 10838 | 29412451 |
Pallor | 10.74 | 10.68 | 159 | 151079 | 20865 | 29402424 |
Orthostatic intolerance | 10.72 | 10.68 | 15 | 151223 | 647 | 29422642 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Iris disorder | 542.38 | 9.96 | 128 | 129288 | 213 | 64369103 |
Urinary retention | 430.15 | 9.96 | 512 | 128904 | 48689 | 64320627 |
Syncope | 293.90 | 9.96 | 836 | 128580 | 156799 | 64212517 |
Fall | 270.04 | 9.96 | 1590 | 127826 | 415236 | 63954080 |
Dizziness | 245.95 | 9.96 | 1589 | 127827 | 428574 | 63940742 |
Benign prostatic hyperplasia | 228.79 | 9.96 | 171 | 129245 | 8994 | 64360322 |
Orthostatic hypotension | 225.08 | 9.96 | 365 | 129051 | 46373 | 64322943 |
Drug ineffective | 222.81 | 9.96 | 901 | 128515 | 839346 | 63529970 |
Idiopathic pulmonary fibrosis | 221.17 | 9.96 | 121 | 129295 | 3679 | 64365637 |
Cataract operation complication | 207.50 | 9.96 | 57 | 129359 | 220 | 64369096 |
Haematuria | 203.60 | 9.96 | 404 | 129012 | 60067 | 64309249 |
Atrial fibrillation | 178.49 | 9.96 | 748 | 128668 | 170341 | 64198975 |
Product prescribing error | 176.05 | 9.96 | 280 | 129136 | 34989 | 64334327 |
Maternal exposure during pregnancy | 173.04 | 9.96 | 4 | 129412 | 95880 | 64273436 |
Iridocele | 169.35 | 9.96 | 36 | 129380 | 24 | 64369292 |
Synovitis | 165.26 | 9.96 | 8 | 129408 | 99082 | 64270234 |
Dysuria | 161.28 | 9.96 | 297 | 129119 | 41760 | 64327556 |
Drug intolerance | 136.94 | 9.96 | 106 | 129310 | 187886 | 64181430 |
Prostate cancer | 136.36 | 9.96 | 183 | 129233 | 19612 | 64349704 |
Rheumatoid arthritis | 129.68 | 9.96 | 85 | 129331 | 164209 | 64205107 |
Alopecia | 127.72 | 9.96 | 88 | 129328 | 165602 | 64203714 |
Pollakiuria | 123.84 | 9.96 | 225 | 129191 | 31305 | 64338011 |
Joint swelling | 123.75 | 9.96 | 150 | 129266 | 215232 | 64154084 |
Hallucination | 122.05 | 9.96 | 372 | 129044 | 72416 | 64296900 |
Toxicity to various agents | 120.02 | 9.96 | 354 | 129062 | 363159 | 64006157 |
Floppy iris syndrome | 118.92 | 9.96 | 39 | 129377 | 306 | 64369010 |
Systemic lupus erythematosus | 115.66 | 9.96 | 11 | 129405 | 77601 | 64291715 |
Hypotension | 115.56 | 9.96 | 1220 | 128196 | 379754 | 63989562 |
Bradycardia | 114.84 | 9.96 | 506 | 128910 | 117713 | 64251603 |
Procedural complication | 113.00 | 9.96 | 103 | 129313 | 7162 | 64362154 |
Nocturia | 112.34 | 9.96 | 125 | 129291 | 11040 | 64358276 |
Treatment failure | 110.41 | 9.96 | 48 | 129368 | 116768 | 64252548 |
Erectile dysfunction | 106.34 | 9.96 | 129 | 129287 | 12498 | 64356818 |
Drug abuse | 103.75 | 9.96 | 69 | 129347 | 132305 | 64237011 |
General physical health deterioration | 103.71 | 9.96 | 734 | 128682 | 203691 | 64165625 |
Drug hypersensitivity | 103.56 | 9.96 | 200 | 129216 | 237615 | 64131701 |
Asthenia | 98.07 | 9.96 | 1299 | 128117 | 426745 | 63942571 |
Prostatic specific antigen increased | 96.72 | 9.96 | 103 | 129313 | 8657 | 64360659 |
Death | 93.04 | 9.96 | 1421 | 127995 | 481284 | 63888032 |
Completed suicide | 92.35 | 9.96 | 195 | 129221 | 224219 | 64145097 |
Arthropathy | 88.31 | 9.96 | 68 | 129348 | 120899 | 64248417 |
Confusional state | 87.07 | 9.96 | 853 | 128563 | 260291 | 64109025 |
Pemphigus | 86.85 | 9.96 | 10 | 129406 | 60691 | 64308625 |
Micturition urgency | 85.88 | 9.96 | 105 | 129311 | 10254 | 64359062 |
Labelled drug-drug interaction medication error | 83.56 | 9.96 | 155 | 129261 | 21907 | 64347409 |
Presyncope | 82.44 | 9.96 | 203 | 129213 | 34886 | 64334430 |
Right atrial hypertrophy | 80.53 | 9.96 | 33 | 129383 | 512 | 64368804 |
Infusion related reaction | 79.05 | 9.96 | 130 | 129286 | 164337 | 64204979 |
Nephrolithiasis | 75.79 | 9.96 | 226 | 129190 | 43457 | 64325859 |
Arthralgia | 73.77 | 9.96 | 552 | 128864 | 441708 | 63927608 |
Urinary incontinence | 73.42 | 9.96 | 198 | 129218 | 35953 | 64333363 |
Prostatomegaly | 73.25 | 9.96 | 55 | 129361 | 2912 | 64366404 |
Urinary tract infection | 72.12 | 9.96 | 746 | 128670 | 230850 | 64138466 |
Product monitoring error | 70.86 | 9.96 | 70 | 129346 | 5384 | 64363932 |
Urogenital haemorrhage | 70.33 | 9.96 | 32 | 129384 | 648 | 64368668 |
Pain | 69.48 | 9.96 | 743 | 128673 | 552768 | 63816548 |
Hypersensitivity | 67.16 | 9.96 | 188 | 129228 | 196264 | 64173052 |
Prostatitis | 65.84 | 9.96 | 56 | 129360 | 3550 | 64365766 |
Glossodynia | 65.34 | 9.96 | 24 | 129392 | 64672 | 64304644 |
Priapism | 65.12 | 9.96 | 58 | 129358 | 3912 | 64365404 |
Haematochezia | 65.10 | 9.96 | 285 | 129131 | 66088 | 64303228 |
Hepatic enzyme increased | 65.00 | 9.96 | 100 | 129316 | 129843 | 64239473 |
Pericarditis | 63.46 | 9.96 | 23 | 129393 | 62493 | 64306823 |
Sinusitis | 63.24 | 9.96 | 123 | 129293 | 145805 | 64223511 |
Therapeutic product effect decreased | 62.40 | 9.96 | 84 | 129332 | 115267 | 64254049 |
Headache | 61.57 | 9.96 | 723 | 128693 | 528744 | 63840572 |
Bladder cancer | 58.75 | 9.96 | 90 | 129326 | 10884 | 64358432 |
Injection site pain | 58.38 | 9.96 | 83 | 129333 | 111325 | 64257991 |
Discomfort | 58.34 | 9.96 | 46 | 129370 | 80832 | 64288484 |
Right ventricular hypertrophy | 58.00 | 9.96 | 35 | 129381 | 1285 | 64368031 |
Plasma cell myeloma | 55.62 | 9.96 | 211 | 129205 | 45864 | 64323452 |
Needle fatigue | 55.59 | 9.96 | 26 | 129390 | 562 | 64368754 |
Subdural haematoma | 55.32 | 9.96 | 152 | 129264 | 27902 | 64341414 |
Intentional overdose | 54.45 | 9.96 | 60 | 129356 | 89884 | 64279432 |
Dyspnoea | 54.09 | 9.96 | 1852 | 127564 | 716822 | 63652494 |
Retrograde ejaculation | 52.59 | 9.96 | 19 | 129397 | 205 | 64369111 |
Drug resistance | 52.22 | 9.96 | 5 | 129411 | 35097 | 64334219 |
Pupillary disorder | 52.17 | 9.96 | 23 | 129393 | 431 | 64368885 |
Pulmonary function test abnormal | 51.45 | 9.96 | 46 | 129370 | 3118 | 64366198 |
Musculoskeletal stiffness | 50.68 | 9.96 | 107 | 129309 | 123099 | 64246217 |
Congenital hiatus hernia | 50.51 | 9.96 | 22 | 129394 | 400 | 64368916 |
Acute kidney injury | 49.22 | 9.96 | 1214 | 128202 | 448026 | 63921290 |
Off label use | 49.04 | 9.96 | 935 | 128481 | 631871 | 63737445 |
Injection site erythema | 48.92 | 9.96 | 42 | 129374 | 70758 | 64298558 |
Migraine | 48.64 | 9.96 | 33 | 129383 | 62644 | 64306672 |
Pneumonia | 47.46 | 9.96 | 1463 | 127953 | 558113 | 63811203 |
Swelling | 47.19 | 9.96 | 164 | 129252 | 160054 | 64209262 |
Orbital myositis | 46.96 | 9.96 | 16 | 129400 | 143 | 64369173 |
Helicobacter infection | 46.58 | 9.96 | 10 | 129406 | 38352 | 64330964 |
Vomiting | 46.55 | 9.96 | 802 | 128614 | 550315 | 63819001 |
Stomatitis | 46.09 | 9.96 | 94 | 129322 | 109511 | 64259805 |
Gait spastic | 45.37 | 9.96 | 26 | 129390 | 866 | 64368450 |
Miosis | 45.06 | 9.96 | 89 | 129327 | 13177 | 64356139 |
Bronchial wall thickening | 44.10 | 9.96 | 34 | 129382 | 1873 | 64367443 |
Fibromyalgia | 44.03 | 9.96 | 9 | 129407 | 35722 | 64333594 |
Anaemia | 43.77 | 9.96 | 1031 | 128385 | 377649 | 63991667 |
Lower urinary tract symptoms | 43.22 | 9.96 | 16 | 129400 | 186 | 64369130 |
Obstruction | 42.78 | 9.96 | 42 | 129374 | 3206 | 64366110 |
Haematoma | 42.64 | 9.96 | 195 | 129221 | 46055 | 64323261 |
Hydronephrosis | 42.35 | 9.96 | 90 | 129326 | 14035 | 64355281 |
Aortic valve stenosis | 42.21 | 9.96 | 49 | 129367 | 4531 | 64364785 |
Lower respiratory tract infection | 41.63 | 9.96 | 79 | 129337 | 94535 | 64274781 |
Gout | 41.21 | 9.96 | 115 | 129301 | 21298 | 64348018 |
Nausea | 40.25 | 9.96 | 1236 | 128180 | 784564 | 63584752 |
Relapsing-remitting multiple sclerosis | 40.16 | 9.96 | 26 | 129390 | 1082 | 64368234 |
Urine flow decreased | 39.68 | 9.96 | 25 | 129391 | 992 | 64368324 |
Bronchial secretion retention | 39.64 | 9.96 | 36 | 129380 | 2491 | 64366825 |
Hypertonic bladder | 39.18 | 9.96 | 41 | 129375 | 3377 | 64365939 |
Chronic obstructive pulmonary disease | 38.86 | 9.96 | 260 | 129156 | 70788 | 64298528 |
Interstitial lung disease | 37.41 | 9.96 | 329 | 129087 | 97403 | 64271913 |
Hospice care | 37.30 | 9.96 | 60 | 129356 | 7565 | 64361751 |
Injection site pruritus | 36.59 | 9.96 | 15 | 129401 | 37811 | 64331505 |
Hepatic vein dilatation | 36.59 | 9.96 | 15 | 129401 | 233 | 64369083 |
Oedema peripheral | 36.53 | 9.96 | 609 | 128807 | 209708 | 64159608 |
Irritable bowel syndrome | 35.86 | 9.96 | 15 | 129401 | 37354 | 64331962 |
Cerebral haemorrhage | 35.55 | 9.96 | 199 | 129217 | 50891 | 64318425 |
Pallor | 34.63 | 9.96 | 162 | 129254 | 38619 | 64330697 |
Plasmapheresis | 34.62 | 9.96 | 19 | 129397 | 581 | 64368735 |
Ejaculation failure | 34.25 | 9.96 | 16 | 129400 | 345 | 64368971 |
Contraindicated product administered | 34.07 | 9.96 | 107 | 129309 | 107722 | 64261594 |
Muscular weakness | 33.98 | 9.96 | 398 | 129018 | 126940 | 64242376 |
Muscle injury | 33.98 | 9.96 | 6 | 129410 | 26431 | 64342885 |
Multiple organ dysfunction syndrome | 33.93 | 9.96 | 98 | 129318 | 101315 | 64268001 |
Urinary tract obstruction | 33.76 | 9.96 | 41 | 129375 | 3976 | 64365340 |
Suicide attempt | 33.29 | 9.96 | 57 | 129359 | 70950 | 64298366 |
Injection site reaction | 33.07 | 9.96 | 27 | 129389 | 46637 | 64322679 |
Nasopharyngitis | 32.95 | 9.96 | 244 | 129172 | 195829 | 64173487 |
Breast cancer | 32.65 | 9.96 | 9 | 129407 | 29139 | 64340177 |
Abdominal pain lower | 32.59 | 9.96 | 122 | 129294 | 26347 | 64342969 |
Respiratory arrest | 32.45 | 9.96 | 35 | 129381 | 52950 | 64316366 |
Liver palpable | 31.75 | 9.96 | 15 | 129401 | 332 | 64368984 |
Head injury | 31.42 | 9.96 | 140 | 129276 | 32702 | 64336614 |
Loss of consciousness | 30.87 | 9.96 | 443 | 128973 | 147922 | 64221394 |
Hypoacusis | 30.84 | 9.96 | 118 | 129298 | 25749 | 64343567 |
Guillain-Barre syndrome | 30.63 | 9.96 | 55 | 129361 | 7580 | 64361736 |
Balance disorder | 30.31 | 9.96 | 279 | 129137 | 83647 | 64285669 |
Vitreous loss | 30.30 | 9.96 | 7 | 129409 | 10 | 64369306 |
Perineal pain | 30.26 | 9.96 | 21 | 129395 | 982 | 64368334 |
Product substitution issue | 29.65 | 9.96 | 91 | 129325 | 17770 | 64351546 |
Abdominal discomfort | 29.63 | 9.96 | 229 | 129187 | 182093 | 64187223 |
Injection site swelling | 29.22 | 9.96 | 24 | 129392 | 41329 | 64327987 |
Delirium | 29.15 | 9.96 | 238 | 129178 | 68956 | 64300360 |
Constipation | 29.14 | 9.96 | 633 | 128783 | 228704 | 64140612 |
Device expulsion | 28.97 | 9.96 | 4 | 129412 | 21132 | 64348184 |
Bladder neck obstruction | 28.91 | 9.96 | 10 | 129406 | 94 | 64369222 |
Platypnoea | 28.90 | 9.96 | 8 | 129408 | 32 | 64369284 |
Dacryocystitis | 28.70 | 9.96 | 8 | 129408 | 33 | 64369283 |
Umbilical hernia | 27.74 | 9.96 | 39 | 129377 | 4366 | 64364950 |
Residual urine volume increased | 27.62 | 9.96 | 7 | 129409 | 18 | 64369298 |
Bladder catheterisation | 27.47 | 9.96 | 18 | 129398 | 765 | 64368551 |
Folliculitis | 27.40 | 9.96 | 13 | 129403 | 30064 | 64339252 |
Infection | 27.40 | 9.96 | 238 | 129178 | 184642 | 64184674 |
Rectal haemorrhage | 27.33 | 9.96 | 215 | 129201 | 61602 | 64307714 |
Intentional product use issue | 27.14 | 9.96 | 99 | 129317 | 95265 | 64274051 |
Diastolic dysfunction | 27.13 | 9.96 | 57 | 129359 | 8818 | 64360498 |
Hyponatraemia | 27.02 | 9.96 | 433 | 128983 | 147906 | 64221410 |
Testicular swelling | 27.00 | 9.96 | 19 | 129397 | 909 | 64368407 |
Drug interaction | 26.82 | 9.96 | 932 | 128484 | 361151 | 64008165 |
Idiopathic interstitial pneumonia | 26.48 | 9.96 | 11 | 129405 | 177 | 64369139 |
Ejaculation disorder | 26.35 | 9.96 | 15 | 129401 | 493 | 64368823 |
Prostatic disorder | 26.25 | 9.96 | 24 | 129392 | 1675 | 64367641 |
Haematospermia | 25.97 | 9.96 | 12 | 129404 | 252 | 64369064 |
Dementia | 25.80 | 9.96 | 96 | 129320 | 20670 | 64348646 |
Cytomegalovirus infection | 25.77 | 9.96 | 22 | 129394 | 37177 | 64332139 |
Inferior vena cava dilatation | 25.64 | 9.96 | 17 | 129399 | 737 | 64368579 |
Faeces discoloured | 25.61 | 9.96 | 111 | 129305 | 25618 | 64343698 |
Stress | 25.37 | 9.96 | 52 | 129364 | 60482 | 64308834 |
Pemphigoid | 25.24 | 9.96 | 70 | 129346 | 12916 | 64356400 |
Arteriovenous fistula | 25.09 | 9.96 | 18 | 129398 | 888 | 64368428 |
Prostatic mass | 25.05 | 9.96 | 6 | 129410 | 11 | 64369305 |
Bladder spasm | 25.05 | 9.96 | 25 | 129391 | 1947 | 64367369 |
Prostate cancer metastatic | 25.01 | 9.96 | 32 | 129384 | 3272 | 64366044 |
Inflammation | 24.97 | 9.96 | 59 | 129357 | 65241 | 64304075 |
Dehydration | 24.94 | 9.96 | 590 | 128826 | 216173 | 64153143 |
Milk-alkali syndrome | 24.85 | 9.96 | 20 | 129396 | 1173 | 64368143 |
Inguinal hernia | 24.72 | 9.96 | 42 | 129374 | 5539 | 64363777 |
Cardiac failure congestive | 24.48 | 9.96 | 383 | 129033 | 130197 | 64239119 |
Puncture site haematoma | 24.07 | 9.96 | 10 | 129406 | 161 | 64369155 |
Poisoning | 24.05 | 9.96 | 7 | 129409 | 21872 | 64347444 |
Drug dependence | 23.95 | 9.96 | 19 | 129397 | 33293 | 64336023 |
Urinary hesitation | 23.49 | 9.96 | 32 | 129384 | 3478 | 64365838 |
Phaeochromocytoma malignant | 23.43 | 9.96 | 8 | 129408 | 72 | 64369244 |
Ventricular enlargement | 23.32 | 9.96 | 14 | 129402 | 509 | 64368807 |
Diabetic neuropathy | 23.31 | 9.96 | 41 | 129375 | 5560 | 64363756 |
Cardio-respiratory arrest | 23.12 | 9.96 | 110 | 129306 | 98283 | 64271033 |
Paraplegia | 22.88 | 9.96 | 36 | 129380 | 4454 | 64364862 |
Atrial enlargement | 22.73 | 9.96 | 15 | 129401 | 645 | 64368671 |
Intestinal haemorrhage | 22.48 | 9.96 | 40 | 129376 | 5474 | 64363842 |
Renal cyst haemorrhage | 22.26 | 9.96 | 13 | 129403 | 449 | 64368867 |
Flushing | 22.15 | 9.96 | 82 | 129334 | 78566 | 64290750 |
Impaired healing | 22.05 | 9.96 | 56 | 129360 | 60417 | 64308899 |
Factitious disorder | 22 | 9.96 | 9 | 129407 | 139 | 64369177 |
Aortic stenosis | 21.98 | 9.96 | 43 | 129373 | 6322 | 64362994 |
Transient ischaemic attack | 21.98 | 9.96 | 158 | 129258 | 44024 | 64325292 |
Benign gastrointestinal neoplasm | 21.94 | 9.96 | 9 | 129407 | 140 | 64369176 |
Prostatic operation | 21.69 | 9.96 | 10 | 129406 | 209 | 64369107 |
Dyspnoea exertional | 21.26 | 9.96 | 234 | 129182 | 73496 | 64295820 |
Vena cava injury | 21.22 | 9.96 | 10 | 129406 | 220 | 64369096 |
Radiation inflammation | 21.14 | 9.96 | 10 | 129406 | 222 | 64369094 |
Therapy non-responder | 21.09 | 9.96 | 65 | 129351 | 65834 | 64303482 |
Psoriatic arthropathy | 20.97 | 9.96 | 34 | 129382 | 43247 | 64326069 |
Tendon pain | 20.84 | 9.96 | 36 | 129380 | 4812 | 64364504 |
Ageusia | 20.75 | 9.96 | 68 | 129348 | 13745 | 64355571 |
Angina pectoris | 20.60 | 9.96 | 158 | 129258 | 44923 | 64324393 |
Mucosal inflammation | 20.55 | 9.96 | 61 | 129355 | 62523 | 64306793 |
Cerebrovascular accident | 20.52 | 9.96 | 389 | 129027 | 137194 | 64232122 |
SARS-CoV-2 antibody test positive | 20.47 | 9.96 | 10 | 129406 | 239 | 64369077 |
Condition aggravated | 20.41 | 9.96 | 580 | 128836 | 371846 | 63997470 |
Urosepsis | 20.25 | 9.96 | 93 | 129323 | 22001 | 64347315 |
Arthritis | 20.10 | 9.96 | 93 | 129323 | 83721 | 64285595 |
Monoparesis | 20.01 | 9.96 | 27 | 129389 | 2907 | 64366409 |
Resting tremor | 19.97 | 9.96 | 19 | 129397 | 1395 | 64367921 |
Acute hepatic failure | 19.92 | 9.96 | 14 | 129402 | 26098 | 64343218 |
Haemoglobin decreased | 19.77 | 9.96 | 522 | 128894 | 194541 | 64174775 |
Subdural hygroma | 19.75 | 9.96 | 12 | 129404 | 446 | 64368870 |
Burning feet syndrome | 19.65 | 9.96 | 8 | 129408 | 122 | 64369194 |
Acquired haemophilia | 19.59 | 9.96 | 20 | 129396 | 1600 | 64367716 |
Arteriosclerotic gangrene | 19.50 | 9.96 | 7 | 129409 | 74 | 64369242 |
Weight increased | 19.41 | 9.96 | 306 | 129110 | 213042 | 64156274 |
Thermal burns of eye | 19.34 | 9.96 | 7 | 129409 | 76 | 64369240 |
Upper gastrointestinal haemorrhage | 19.32 | 9.96 | 129 | 129287 | 35091 | 64334225 |
Renal haematoma | 19.21 | 9.96 | 14 | 129402 | 708 | 64368608 |
Serum ferritin abnormal | 18.81 | 9.96 | 11 | 129405 | 381 | 64368935 |
Product use issue | 18.80 | 9.96 | 204 | 129212 | 151511 | 64217805 |
Hepatotoxicity | 18.80 | 9.96 | 32 | 129384 | 39930 | 64329386 |
Dizziness postural | 18.40 | 9.96 | 52 | 129364 | 9700 | 64359616 |
Inappropriate antidiuretic hormone secretion | 18.38 | 9.96 | 91 | 129325 | 22198 | 64347118 |
Gastrointestinal haemorrhage | 18.35 | 9.96 | 370 | 129046 | 131942 | 64237374 |
Coma | 18.29 | 9.96 | 102 | 129314 | 87513 | 64281803 |
Urticaria | 18.29 | 9.96 | 198 | 129218 | 147119 | 64222197 |
Vertigo | 18.28 | 9.96 | 190 | 129226 | 58821 | 64310495 |
Genital swelling | 18.28 | 9.96 | 10 | 129406 | 304 | 64369012 |
Testicular pain | 18.21 | 9.96 | 20 | 129396 | 1740 | 64367576 |
Bladder tamponade | 18.21 | 9.96 | 12 | 129404 | 515 | 64368801 |
Injection site bruising | 18.17 | 9.96 | 28 | 129388 | 36345 | 64332971 |
Blood pressure decreased | 18.16 | 9.96 | 258 | 129158 | 85941 | 64283375 |
Hormone receptor positive breast cancer | 18.16 | 9.96 | 10 | 129406 | 308 | 64369008 |
Wrong schedule | 18.04 | 9.96 | 10 | 129406 | 312 | 64369004 |
Intentional self-injury | 17.99 | 9.96 | 19 | 129397 | 29025 | 64340291 |
Cardiac disorder | 17.90 | 9.96 | 181 | 129235 | 55635 | 64313681 |
Choroidal detachment | 17.90 | 9.96 | 12 | 129404 | 530 | 64368786 |
COVID-19 pneumonia | 17.83 | 9.96 | 73 | 129343 | 16431 | 64352885 |
Cornea verticillata | 17.80 | 9.96 | 7 | 129409 | 97 | 64369219 |
Alanine aminotransferase increased | 17.61 | 9.96 | 186 | 129230 | 138845 | 64230471 |
Hyperkalaemia | 17.59 | 9.96 | 293 | 129123 | 100836 | 64268480 |
Wrong patient received product | 17.58 | 9.96 | 29 | 129387 | 3733 | 64365583 |
Hepatitis | 17.57 | 9.96 | 41 | 129375 | 45541 | 64323775 |
Orthopnoea | 17.52 | 9.96 | 49 | 129367 | 9085 | 64360231 |
Narrow anterior chamber angle | 17.49 | 9.96 | 8 | 129408 | 164 | 64369152 |
Ill-defined disorder | 17.49 | 9.96 | 39 | 129377 | 44013 | 64325303 |
Bronchiectasis | 17.26 | 9.96 | 65 | 129351 | 14075 | 64355241 |
Oropharyngeal pain | 17.20 | 9.96 | 106 | 129310 | 88761 | 64280555 |
Systemic infection | 17.17 | 9.96 | 31 | 129385 | 4290 | 64365026 |
Pharyngeal cancer | 17.16 | 9.96 | 5 | 129411 | 25 | 64369291 |
Chest X-ray abnormal | 17.14 | 9.96 | 40 | 129376 | 6641 | 64362675 |
Febrile neutropenia | 17.11 | 9.96 | 269 | 129147 | 187388 | 64181928 |
Bulbar palsy | 17.09 | 9.96 | 9 | 129407 | 253 | 64369063 |
Prostatic obstruction | 16.93 | 9.96 | 6 | 129410 | 61 | 64369255 |
Gastrointestinal disorder | 16.85 | 9.96 | 108 | 129308 | 89601 | 64279715 |
Urinary bladder haemorrhage | 16.69 | 9.96 | 22 | 129394 | 2316 | 64367000 |
Gait disturbance | 16.67 | 9.96 | 458 | 128958 | 171697 | 64197619 |
Mydriasis | 16.65 | 9.96 | 5 | 129411 | 15307 | 64354009 |
Femoral artery aneurysm | 16.57 | 9.96 | 8 | 129408 | 186 | 64369130 |
Overdose | 16.55 | 9.96 | 223 | 129193 | 159343 | 64209973 |
Leukopenia | 16.51 | 9.96 | 127 | 129289 | 101115 | 64268201 |
Impaired work ability | 16.49 | 9.96 | 5 | 129411 | 15214 | 64354102 |
Prostate infection | 16.33 | 9.96 | 11 | 129405 | 490 | 64368826 |
Bone marrow failure | 16.28 | 9.96 | 46 | 129370 | 47906 | 64321410 |
Cerebral haematoma | 16.27 | 9.96 | 41 | 129375 | 7144 | 64362172 |
Ligament pain | 16.23 | 9.96 | 8 | 129408 | 195 | 64369121 |
Iris haemorrhage | 16.16 | 9.96 | 4 | 129412 | 9 | 64369307 |
Hepatic failure | 16.09 | 9.96 | 57 | 129359 | 55337 | 64313979 |
Bladder outlet obstruction | 16.04 | 9.96 | 7 | 129409 | 128 | 64369188 |
Graft versus host disease | 15.98 | 9.96 | 4 | 129412 | 13809 | 64355507 |
Therapeutic product effect incomplete | 15.86 | 9.96 | 132 | 129284 | 103350 | 64265966 |
Haematemesis | 15.84 | 9.96 | 154 | 129262 | 46845 | 64322471 |
Micturition disorder | 15.71 | 9.96 | 25 | 129391 | 3123 | 64366193 |
Iris injury | 15.64 | 9.96 | 3 | 129413 | 0 | 64369316 |
Sperm concentration zero | 15.64 | 9.96 | 3 | 129413 | 0 | 64369316 |
Orchitis | 15.63 | 9.96 | 15 | 129401 | 1113 | 64368203 |
Internal haemorrhage | 15.57 | 9.96 | 42 | 129374 | 7625 | 64361691 |
Memory impairment | 15.55 | 9.96 | 250 | 129166 | 85432 | 64283884 |
Myelosuppression | 15.43 | 9.96 | 15 | 129401 | 23815 | 64345501 |
Inadequate osteointegration | 15.33 | 9.96 | 4 | 129412 | 12 | 64369304 |
Tendon discomfort | 15.26 | 9.96 | 10 | 129406 | 425 | 64368891 |
Full blood count abnormal | 15.14 | 9.96 | 107 | 129309 | 29650 | 64339666 |
Aspergillus infection | 15.04 | 9.96 | 7 | 129409 | 16372 | 64352944 |
Forced expiratory flow decreased | 14.96 | 9.96 | 8 | 129408 | 232 | 64369084 |
Candida infection | 14.92 | 9.96 | 25 | 129391 | 31394 | 64337922 |
Bladder obstruction | 14.87 | 9.96 | 10 | 129406 | 444 | 64368872 |
Haemorrhage urinary tract | 14.86 | 9.96 | 20 | 129396 | 2149 | 64367167 |
Dysgeusia | 14.82 | 9.96 | 152 | 129264 | 46895 | 64322421 |
Faecaloma | 14.71 | 9.96 | 48 | 129368 | 9680 | 64359636 |
Suprapubic pain | 14.69 | 9.96 | 13 | 129403 | 869 | 64368447 |
Circadian rhythm sleep disorder | 14.67 | 9.96 | 11 | 129405 | 581 | 64368735 |
Oesophageal rupture | 14.63 | 9.96 | 13 | 129403 | 874 | 64368442 |
Intraductal papillary mucinous neoplasm | 14.59 | 9.96 | 11 | 129405 | 586 | 64368730 |
Blood glucose fluctuation | 14.57 | 9.96 | 35 | 129381 | 5920 | 64363396 |
Tenosynovitis | 14.54 | 9.96 | 3 | 129413 | 11830 | 64357486 |
Blood urine present | 14.50 | 9.96 | 74 | 129342 | 18266 | 64351050 |
Executive dysfunction | 14.48 | 9.96 | 8 | 129408 | 248 | 64369068 |
Atrioventricular block | 14.48 | 9.96 | 55 | 129361 | 11960 | 64357356 |
Haematotoxicity | 14.41 | 9.96 | 4 | 129412 | 12892 | 64356424 |
Arrhythmia | 14.34 | 9.96 | 166 | 129250 | 52778 | 64316538 |
Gynaecomastia | 14.33 | 9.96 | 35 | 129381 | 5981 | 64363335 |
Flank pain | 13.99 | 9.96 | 67 | 129349 | 16122 | 64353194 |
Urinary tract infection staphylococcal | 13.96 | 9.96 | 12 | 129404 | 772 | 64368544 |
Red blood cell sedimentation rate increased | 13.80 | 9.96 | 26 | 129390 | 31209 | 64338107 |
Disorientation | 13.79 | 9.96 | 172 | 129244 | 55656 | 64313660 |
Bladder transitional cell carcinoma | 13.75 | 9.96 | 20 | 129396 | 2310 | 64367006 |
International normalised ratio increased | 13.63 | 9.96 | 229 | 129187 | 78938 | 64290378 |
Renal colic | 13.60 | 9.96 | 20 | 129396 | 2332 | 64366984 |
Injection site warmth | 13.58 | 9.96 | 5 | 129411 | 13457 | 64355859 |
Mixed dementia | 13.55 | 9.96 | 8 | 129408 | 282 | 64369034 |
Hip fracture | 13.53 | 9.96 | 97 | 129319 | 27002 | 64342314 |
Fatigue | 13.51 | 9.96 | 1707 | 127709 | 747023 | 63622293 |
Penis disorder | 13.39 | 9.96 | 12 | 129404 | 816 | 64368500 |
Dysphagia | 13.28 | 9.96 | 294 | 129122 | 106518 | 64262798 |
Muscle haemorrhage | 13.21 | 9.96 | 33 | 129383 | 5720 | 64363596 |
Product prescribing issue | 13.14 | 9.96 | 19 | 129397 | 2182 | 64367134 |
Posterior reversible encephalopathy syndrome | 13.13 | 9.96 | 16 | 129400 | 22930 | 64346386 |
Nipple pain | 13.13 | 9.96 | 10 | 129406 | 541 | 64368775 |
Food aversion | 13.07 | 9.96 | 11 | 129405 | 687 | 64368629 |
Abdominal wall haemorrhage | 13.06 | 9.96 | 9 | 129407 | 416 | 64368900 |
Dry eye | 12.96 | 9.96 | 24 | 129392 | 28995 | 64340321 |
Gait inability | 12.92 | 9.96 | 136 | 129280 | 42232 | 64327084 |
Orthostatic intolerance | 12.91 | 9.96 | 16 | 129400 | 1584 | 64367732 |
Wound haemorrhage | 12.86 | 9.96 | 24 | 129392 | 3407 | 64365909 |
Acute respiratory failure | 12.84 | 9.96 | 155 | 129261 | 49779 | 64319537 |
Thoracic haemorrhage | 12.82 | 9.96 | 7 | 129409 | 212 | 64369104 |
Drug eruption | 12.76 | 9.96 | 34 | 129382 | 36102 | 64333214 |
Haemophagocytic lymphohistiocytosis | 12.71 | 9.96 | 10 | 129406 | 17599 | 64351717 |
Dacryostenosis acquired | 12.71 | 9.96 | 9 | 129407 | 435 | 64368881 |
Mucosal haemorrhage | 12.62 | 9.96 | 19 | 129397 | 2262 | 64367054 |
Periorbital haematoma | 12.58 | 9.96 | 12 | 129404 | 884 | 64368432 |
Anal incontinence | 12.50 | 9.96 | 62 | 129354 | 15134 | 64354182 |
Carotid arteriosclerosis | 12.49 | 9.96 | 18 | 129398 | 2061 | 64367255 |
Pain in jaw | 12.48 | 9.96 | 41 | 129375 | 40714 | 64328602 |
Therapeutic response decreased | 12.46 | 9.96 | 58 | 129358 | 52130 | 64317186 |
Mesenteric vascular insufficiency | 12.45 | 9.96 | 6 | 129410 | 139 | 64369177 |
Knee arthroplasty | 12.35 | 9.96 | 22 | 129394 | 26977 | 64342339 |
Prostatic haemorrhage | 12.29 | 9.96 | 6 | 129410 | 143 | 64369173 |
Herpes simplex | 12.28 | 9.96 | 3 | 129413 | 10533 | 64358783 |
Acne | 12.28 | 9.96 | 17 | 129399 | 23064 | 64346252 |
Myasthenia gravis | 12.23 | 9.96 | 32 | 129384 | 5706 | 64363610 |
Hyponatraemic syndrome | 12.22 | 9.96 | 11 | 129405 | 752 | 64368564 |
Cardiac failure | 12.21 | 9.96 | 350 | 129066 | 132023 | 64237293 |
Breath sounds abnormal | 12.12 | 9.96 | 51 | 129365 | 11618 | 64357698 |
Oral herpes | 12.10 | 9.96 | 16 | 129400 | 22136 | 64347180 |
Flatulence | 12.09 | 9.96 | 117 | 129299 | 35549 | 64333767 |
Troponin increased | 12.08 | 9.96 | 62 | 129354 | 15337 | 64353979 |
Epidermolysis | 12.08 | 9.96 | 9 | 129407 | 471 | 64368845 |
Haemoptysis | 12.07 | 9.96 | 151 | 129265 | 48897 | 64320419 |
Rib fracture | 11.97 | 9.96 | 86 | 129330 | 23952 | 64345364 |
Basosquamous carcinoma | 11.95 | 9.96 | 5 | 129411 | 82 | 64369234 |
Ear pain | 11.94 | 9.96 | 20 | 129396 | 25116 | 64344200 |
Drug reaction with eosinophilia and systemic symptoms | 11.94 | 9.96 | 62 | 129354 | 54155 | 64315161 |
Erection increased | 11.92 | 9.96 | 8 | 129408 | 354 | 64368962 |
Respiratory tract inflammation | 11.90 | 9.96 | 11 | 129405 | 779 | 64368537 |
Sedation | 11.82 | 9.96 | 43 | 129373 | 41419 | 64327897 |
Renal stone removal | 11.82 | 9.96 | 6 | 129410 | 156 | 64369160 |
Tandem gait test abnormal | 11.82 | 9.96 | 4 | 129412 | 35 | 64369281 |
Therapy partial responder | 11.79 | 9.96 | 3 | 129413 | 10245 | 64359071 |
Urinary tract disorder | 11.68 | 9.96 | 22 | 129394 | 3144 | 64366172 |
Xanthelasma | 11.68 | 9.96 | 6 | 129410 | 160 | 64369156 |
Hepatomegaly | 11.68 | 9.96 | 10 | 129406 | 16872 | 64352444 |
Wound haematoma | 11.65 | 9.96 | 6 | 129410 | 161 | 64369155 |
Malpositioned teeth | 11.62 | 9.96 | 4 | 129412 | 37 | 64369279 |
Bladder dysfunction | 11.57 | 9.96 | 12 | 129404 | 978 | 64368338 |
Dyspnoea paroxysmal nocturnal | 11.53 | 9.96 | 17 | 129399 | 1987 | 64367329 |
Human ehrlichiosis | 11.47 | 9.96 | 8 | 129408 | 377 | 64368939 |
Bladder disorder | 11.46 | 9.96 | 38 | 129378 | 7729 | 64361587 |
Adenocarcinoma gastric | 11.37 | 9.96 | 15 | 129401 | 1580 | 64367736 |
Full blood count decreased | 11.37 | 9.96 | 81 | 129335 | 22501 | 64346815 |
Breast disorder male | 11.26 | 9.96 | 3 | 129413 | 10 | 64369306 |
Peripheral artery stenosis | 11.25 | 9.96 | 13 | 129403 | 1196 | 64368120 |
Atrial flutter | 11.25 | 9.96 | 72 | 129344 | 19308 | 64350008 |
Adverse event | 11.23 | 9.96 | 41 | 129375 | 39448 | 64329868 |
Cellulitis gangrenous | 11.22 | 9.96 | 7 | 129409 | 273 | 64369043 |
Atrioventricular block first degree | 11.22 | 9.96 | 47 | 129369 | 10687 | 64358629 |
Dyspnoea at rest | 11.22 | 9.96 | 33 | 129383 | 6296 | 64363020 |
Weight decreased | 11.19 | 9.96 | 690 | 128726 | 285049 | 64084267 |
Intervertebral disc degeneration | 11.13 | 9.96 | 54 | 129362 | 13066 | 64356250 |
Foot fracture | 11.11 | 9.96 | 12 | 129404 | 18145 | 64351171 |
Device difficult to use | 11.02 | 9.96 | 3 | 129413 | 9795 | 64359521 |
Rash | 11.00 | 9.96 | 782 | 128634 | 457767 | 63911549 |
Cytomegalovirus viraemia | 10.96 | 9.96 | 4 | 129412 | 10824 | 64358492 |
Central nervous system lesion | 10.95 | 9.96 | 50 | 129366 | 11799 | 64357517 |
Blood loss anaemia | 10.95 | 9.96 | 56 | 129360 | 13836 | 64355480 |
Lichenoid keratosis | 10.88 | 9.96 | 22 | 129394 | 3312 | 64366004 |
Nodule | 10.83 | 9.96 | 12 | 129404 | 17935 | 64351381 |
Wrong patient | 10.80 | 9.96 | 6 | 129410 | 188 | 64369128 |
Blister | 10.79 | 9.96 | 107 | 129309 | 80860 | 64288456 |
Intentional product misuse | 10.73 | 9.96 | 93 | 129323 | 72202 | 64297114 |
Subdural haemorrhage | 10.72 | 9.96 | 29 | 129387 | 5274 | 64364042 |
Unemployment | 10.69 | 9.96 | 4 | 129412 | 48 | 64369268 |
Mononuclear cell count abnormal | 10.64 | 9.96 | 3 | 129413 | 13 | 64369303 |
Prostatic adenoma | 10.61 | 9.96 | 5 | 129411 | 110 | 64369206 |
Mean cell volume increased | 10.61 | 9.96 | 28 | 129388 | 5018 | 64364298 |
Disseminated Bacillus Calmette-Guerin infection | 10.58 | 9.96 | 6 | 129410 | 196 | 64369120 |
Penile swelling | 10.56 | 9.96 | 9 | 129407 | 572 | 64368744 |
Abnormal dreams | 10.55 | 9.96 | 45 | 129371 | 10311 | 64359005 |
Urinary straining | 10.54 | 9.96 | 4 | 129412 | 50 | 64369266 |
Scrotal swelling | 10.42 | 9.96 | 11 | 129405 | 915 | 64368401 |
Scrotal pain | 10.40 | 9.96 | 8 | 129408 | 439 | 64368877 |
Coagulation factor VII level decreased | 10.38 | 9.96 | 6 | 129410 | 203 | 64369113 |
Injection site erosion | 10.33 | 9.96 | 5 | 129411 | 117 | 64369199 |
Testicular infarction | 10.30 | 9.96 | 3 | 129413 | 15 | 64369301 |
Human anaplasmosis | 10.20 | 9.96 | 4 | 129412 | 55 | 64369261 |
Thrombotic microangiopathy | 10.20 | 9.96 | 11 | 129405 | 16644 | 64352672 |
Bradyarrhythmia | 10.19 | 9.96 | 23 | 129393 | 3735 | 64365581 |
Sleep apnoea syndrome | 10.18 | 9.96 | 98 | 129318 | 29734 | 64339582 |
Squamous cell carcinoma of skin | 10.16 | 9.96 | 49 | 129367 | 11827 | 64357489 |
Hip arthroplasty | 10.13 | 9.96 | 17 | 129399 | 21334 | 64347982 |
Mantle cell lymphoma | 10.11 | 9.96 | 12 | 129404 | 1136 | 64368180 |
Brain oedema | 10.09 | 9.96 | 18 | 129398 | 22057 | 64347259 |
Cold sweat | 10.09 | 9.96 | 62 | 129354 | 16393 | 64352923 |
Renal impairment | 10.08 | 9.96 | 348 | 129068 | 134669 | 64234647 |
Cardiotoxicity | 10.06 | 9.96 | 4 | 129412 | 10270 | 64359046 |
Ludwig angina | 10.00 | 9.96 | 6 | 129410 | 218 | 64369098 |
Foot deformity | 9.99 | 9.96 | 11 | 129405 | 16493 | 64352823 |
None
Source | Code | Description |
---|---|---|
ATC | G04CA02 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists |
ATC | G04CA52 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists |
ATC | G04CA53 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists |
ATC | G04CA54 | GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists |
FDA MoA | N0000000099 | Adrenergic alpha-Antagonists |
FDA EPC | N0000175553 | alpha-Adrenergic Blocker |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D058668 | Adrenergic alpha-1 Receptor Antagonists |
MeSH PA | D000317 | Adrenergic alpha-Antagonists |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D064804 | Urological Agents |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:37890 | alpha-adrenergic receptor blockaders |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Benign prostatic hyperplasia | indication | 266569009 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Orthostatic hypotension | contraindication | 28651003 | |
Oligozoospermia | contraindication | 88311004 | |
Cataract surgery | contraindication | 110473004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Dizziness | contraindication | 404640003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Intraoperative floppy iris syndrome | contraindication | 418801006 | |
High-Grade Prostate Cancer | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.71 | acidic |
pKa2 | 8.16 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | Ki | 7.89 | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 7.87 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 9.10 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 7.08 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 10.54 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 9.55 | CHEMBL | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 8.10 | CHEMBL | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 10.24 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 9.21 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 8.17 | CHEMBL | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 10.15 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 9.90 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 9.70 | CHEMBL | |||||
Serotonin 1 (5-HT1) receptor | GPCR | Ki | 6.03 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 10.52 | CHEMBL |
ID | Source |
---|---|
4024076 | VUID |
N0000022081 | NUI |
D01024 | KEGG_DRUG |
106463-17-6 | SECONDARY_CAS_RN |
4021051 | VANDF |
4024076 | VANDF |
C0257343 | UMLSCUI |
CHEBI:9398 | CHEBI |
CHEMBL836 | ChEMBL_ID |
CHEMBL1200914 | ChEMBL_ID |
D000077409 | MESH_DESCRIPTOR_UI |
DB00706 | DRUGBANK_ID |
129211 | PUBCHEM_CID |
488 | IUPHAR_LIGAND_ID |
6750 | INN_ID |
G3P28OML5I | UNII |
236495 | RXNORM |
171693 | MMSL |
20642 | MMSL |
5541 | MMSL |
d04121 | MMSL |
006115 | NDDF |
006116 | NDDF |
108559004 | SNOMEDCT_US |
108560009 | SNOMEDCT_US |
372509005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
FLOMAX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0024-5837 | CAPSULE | 0.40 mg | ORAL | NDA | 30 sections |
JALYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0173-0809 | CAPSULE | 0.40 mg | ORAL | NDA | 29 sections |
Tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2996 | CAPSULE | 0.40 mg | ORAL | ANDA | 19 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7995 | CAPSULE | 0.40 mg | ORAL | ANDA | 26 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8055 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-2076 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6401 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Dutasteride and Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10370-280 | CAPSULE | 0.40 mg | ORAL | ANDA | 28 sections |
Tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-280 | CAPSULE | 0.40 mg | ORAL | ANDA | 18 sections |
TAMSULOSIN HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-550 | CAPSULE | 0.40 mg | ORAL | ANDA | 17 sections |
TAMSULOSIN HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-298 | CAPSULE | 0.40 mg | ORAL | ANDA | 17 sections |
FLOMAX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-489 | CAPSULE | 0.40 mg | ORAL | NDA | 28 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 16714-713 | CAPSULE | 0.40 mg | ORAL | ANDA | 26 sections |
TAMSULOSIN HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-839 | CAPSULE | 0.40 mg | ORAL | ANDA | 17 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 33342-159 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
TAMSULOSIN HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-012 | CAPSULE | 0.40 mg | ORAL | ANDA | 17 sections |
Tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-264 | CAPSULE | 0.40 mg | ORAL | ANDA | 19 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-725 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-725 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-947 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-947 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-013 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 43353-019 | CAPSULE | 0.40 mg | ORAL | ANDA | 26 sections |
Tamsulosin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-663 | CAPSULE | 0.40 mg | ORAL | ANDA | 19 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 50090-1846 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 50090-3646 | CAPSULE | 0.40 mg | ORAL | ANDA | 29 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 50090-4906 | CAPSULE | 0.40 mg | ORAL | ANDA | 29 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 50090-5553 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |
Tamsulosin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-740 | CAPSULE | 0.40 mg | ORAL | ANDA | 30 sections |
Tamsulosin Hydrochloride | Human Prescription Drug Label | 1 | 50436-0598 | CAPSULE | 0.40 mg | ORAL | ANDA | 27 sections |