All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

tamsulosin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihypertensive substances, prazosin derivatives	2562	106133-20-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: tamsulosin tamsulosin hydrochloride tamsulosin HCl LY-253352	A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA. Molecular weight: 408.51 Formula: C20H28N2O5S CLOGP: 2.17 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 99.88 ALOGS: -4.79 ROTB: 11 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	8.70 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.03 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.21 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.62 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	6.80 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
April 15, 1997	FDA	BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Nephrolithiasis	187.74	14.56	101	9254	41883	63437784
Urinary tract infection	93.09	14.56	151	9204	264533	63215134
Multiple sclerosis relapse	72.86	14.56	59	9296	48419	63431248
Urinary retention	58.94	14.56	43	9312	30258	63449409
Residual urine volume increased	40.09	14.56	7	9348	50	63479617
Renal colic	36.31	14.56	12	9343	1469	63478198
Ligament pain	36.14	14.56	8	9347	211	63479456
Multiple sclerosis	35.20	14.56	29	9326	24343	63455324
Drug ineffective	33.33	14.56	65	9290	1044700	62434967
Respiratory tract inflammation	32.64	14.56	9	9346	595	63479072
Catarrh	31.86	14.56	11	9344	1538	63478129
Steroid dependence	30.46	14.56	11	9344	1753	63477914
Burns second degree	29.24	14.56	11	9344	1967	63477700
Vertigo	27.83	14.56	39	9316	59848	63419819
COVID-19	27.41	14.56	55	9300	113048	63366619
Renal stone removal	27.41	14.56	6	9349	150	63479517
Pertussis	27.02	14.56	8	9347	683	63478984
Fall	26.40	14.56	121	9234	392213	63087454
Syncope	24.85	14.56	54	9301	117331	63362336
Progressive multifocal leukoencephalopathy	24.29	14.56	18	9337	12953	63466714
Drug dispensed to wrong patient	23.09	14.56	6	9349	316	63479351
Decreased vibratory sense	22.78	14.56	6	9349	333	63479334
Hypopnoea	22.31	14.56	11	9344	3795	63475872
Disorganised speech	22.26	14.56	8	9347	1257	63478410
Gingival pain	21.58	14.56	14	9341	8148	63471519
Urinary tract obstruction	21.21	14.56	9	9346	2199	63477468
Joint swelling	21.09	14.56	11	9344	327655	63152012
Product use in unapproved indication	20.98	14.56	66	9289	179014	63300653
Rheumatoid arthritis	20.47	14.56	6	9349	253813	63225854
Hydronephrosis	20.43	14.56	15	9340	10647	63469020
Sinus pain	20.42	14.56	10	9345	3400	63476267
Immune reconstitution inflammatory syndrome	20.03	14.56	12	9343	6072	63473595
Micturition urgency	19.50	14.56	14	9341	9597	63470070
Chorioretinitis	19.35	14.56	6	9349	599	63479068
Iris disorder	18.81	14.56	4	9351	87	63479580
Flank pain	18.58	14.56	17	9338	16393	63463274
Urinary incontinence	18.17	14.56	23	9332	31991	63447676
Drug intolerance	17.55	14.56	12	9343	308649	63171018
Erythropenia	15.90	14.56	4	9351	185	63479482
Hypotension	15.37	14.56	80	9275	272524	63207143
Central nervous system stimulation	15.16	14.56	3	9352	45	63479622
Impaired quality of life	15.07	14.56	14	9341	13769	63465898
Heparin-induced thrombocytopenia	14.99	14.56	9	9346	4573	63475094
Hypertensive nephropathy	14.86	14.56	5	9350	647	63479020
Cystitis	14.84	14.56	28	9327	54963	63424704
Tendon pain	14.83	14.56	8	9347	3318	63476349
Orthopnoea	14.76	14.56	10	9345	6251	63473416

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Iris disorder	728.36	10.84	197	173564	168	34783002
Fall	382.12	10.84	2002	171759	200883	34582287
Dizziness	378.94	10.84	2108	171653	216413	34566757
Urinary retention	337.63	10.84	629	173132	35659	34747511
Orthostatic hypotension	277.88	10.84	478	173283	25441	34757729
Drug abuse	264.04	10.84	82	173679	99014	34684156
Cataract operation complication	246.14	10.84	71	173690	95	34783075
Syncope	235.96	10.84	990	172771	90461	34692709
Toxicity to various agents	230.25	10.84	402	173359	199960	34583210
Iridocele	223.66	10.84	57	173704	27	34783143
Urinary tract infection	215.93	10.84	909	172852	83172	34699998
Benign prostatic hyperplasia	170.90	10.84	279	173482	14216	34768954
Procedural complication	168.12	10.84	152	173609	4131	34779039
Drug ineffective	167.24	10.84	1461	172300	455290	34327880
Product prescribing error	164.78	10.84	357	173404	22570	34760600
Dysuria	163.27	10.84	394	173367	26758	34756412
Floppy iris syndrome	152.72	10.84	58	173703	259	34782911
Off label use	144.25	10.84	1363	172398	418161	34365009
Nocturia	137.64	10.84	209	173552	10001	34773169
Idiopathic pulmonary fibrosis	135.93	10.84	124	173637	3410	34779760
Micturition urgency	134.27	10.84	164	173597	6361	34776809
Completed suicide	132.77	10.84	176	173585	97992	34685178
Pollakiuria	128.62	10.84	295	173466	19379	34763791
Atrial fibrillation	126.00	10.84	1039	172722	121354	34661816
Multiple organ dysfunction syndrome	125.78	10.84	117	173644	76449	34706721
Haematuria	110.07	10.84	517	173244	49549	34733621
Urinary incontinence	107.21	10.84	268	173493	18606	34764564
Fatigue	98.51	10.84	2473	171288	368180	34414990
Retrograde ejaculation	93.96	10.84	45	173716	388	34782782
Drug resistance	93.35	10.84	10	173751	25917	34757253
Asthenia	88.44	10.84	1710	172051	243541	34539629
Febrile neutropenia	85.82	10.84	369	173392	136480	34646690
Treatment failure	85.74	10.84	64	173697	46633	34736537
Product monitoring error	85.14	10.84	107	173654	4274	34778896
Dyspnoea	81.40	10.84	2448	171313	374334	34408836
Right atrial hypertrophy	77.76	10.84	49	173712	756	34782414
Intentional overdose	74.99	10.84	64	173697	43610	34739560
Presyncope	71.48	10.84	233	173528	18826	34764344
Pupillary disorder	68.18	10.84	33	173728	292	34782878
Urogenital haemorrhage	66.14	10.84	43	173718	702	34782468
Hypotension	65.68	10.84	1502	172259	220147	34563023
Cytomegalovirus infection	65.41	10.84	24	173737	26111	34757059
Thrombocytopenia	64.49	10.84	483	173278	155764	34627406
Balance disorder	64.05	10.84	383	173378	40271	34742899
Suicide attempt	62.77	10.84	61	173700	39055	34744115
Prostatomegaly	61.86	10.84	102	173659	5239	34777931
Drug dependence	61.01	10.84	22	173739	24195	34758975
Confusional state	60.94	10.84	1031	172730	143129	34640041
Right ventricular hypertrophy	57.39	10.84	53	173708	1481	34781689
Bronchial secretion retention	57.33	10.84	53	173708	1483	34781687
Hallucination	57.16	10.84	445	173316	51053	34732117
Myelosuppression	56.82	10.84	13	173748	19252	34763918
Congenital hiatus hernia	56.66	10.84	41	173720	803	34782367
Labelled drug-drug interaction medication error	56.35	10.84	183	173578	14756	34768414
Hypertonic bladder	55.83	10.84	57	173704	1807	34781363
Bradycardia	55.81	10.84	597	173164	74821	34708349
Aortic valve stenosis	55.71	10.84	68	173693	2635	34780535
General physical health deterioration	54.07	10.84	917	172844	127352	34655818
Fractional exhaled nitric oxide increased	53.86	10.84	44	173717	1038	34782132
Dyspnoea exertional	53.70	10.84	384	173377	42895	34740275
Prostatic disorder	52.83	10.84	74	173687	3288	34779882
Myoglobin blood increased	51.21	10.84	69	173692	2954	34780216
Pulmonary function test abnormal	51.12	10.84	64	173697	2546	34780624
Respiratory arrest	50.75	10.84	39	173722	28004	34755166
Bronchial wall thickening	50.67	10.84	47	173714	1321	34781849
Urine flow decreased	50.50	10.84	45	173716	1199	34781971
Needle fatigue	48.49	10.84	38	173723	843	34782327
Obstructive airways disorder	48.17	10.84	178	173583	15316	34767854
Leukopenia	48.16	10.84	156	173605	62700	34720470
Abdominal pain lower	47.82	10.84	138	173623	10433	34772737
Priapism	46.94	10.84	87	173674	4907	34778263
Prostatic specific antigen increased	45.93	10.84	169	173592	14511	34768659
Cardio-respiratory arrest	45.31	10.84	133	173628	55140	34728030
Bladder disorder	45.05	10.84	68	173693	3236	34779934
Constipation	44.21	10.84	940	172821	136042	34647128
Mucosal inflammation	43.76	10.84	78	173683	38544	34744626
Pyrexia	43.54	10.84	1292	172469	331721	34451449
Alanine aminotransferase increased	43.54	10.84	230	173531	80585	34702585
Relapsing-remitting multiple sclerosis	42.66	10.84	38	173723	1012	34782158
Ocular procedural complication	42.45	10.84	15	173746	52	34783118
Hypoacusis	41.58	10.84	176	173585	16125	34767045
Gait spastic	41.26	10.84	38	173723	1058	34782112
Cardiac arrest	41.20	10.84	294	173467	95865	34687305
Ascites	41.20	10.84	108	173653	46463	34736707
Obstruction	40.01	10.84	58	173703	2661	34780509
Cardiogenic shock	39.89	10.84	44	173717	26574	34756596
Overdose	39.70	10.84	277	173484	90782	34692388
Vomiting	39.62	10.84	933	172828	246688	34536482
Cataract operation	39.59	10.84	40	173721	1252	34781918
Intentional product use issue	39.49	10.84	158	173603	59658	34723512
Bone marrow failure	38.94	10.84	53	173708	29200	34753970
Miosis	38.89	10.84	120	173641	9415	34773755
Synovitis	38.58	10.84	11	173750	14055	34769115
Memory impairment	38.38	10.84	356	173405	42962	34740208
Coma	38.11	10.84	109	173652	45569	34737601
Ventricular fibrillation	37.76	10.84	35	173726	22919	34760251
Drug intolerance	37.67	10.84	160	173601	59410	34723760
Full blood count abnormal	36.86	10.84	187	173574	18481	34764689
Hospice care	36.76	10.84	96	173665	6844	34776326
Therapy partial responder	36.50	10.84	3	173758	9613	34773557
Ejaculation failure	36.34	10.84	31	173730	778	34782392
Haematochezia	36.12	10.84	372	173389	46162	34737008
Systemic infection	36.12	10.84	80	173681	5132	34778038
Vertigo	36.10	10.84	234	173527	25302	34757868
Neutropenia	36.06	10.84	555	173206	156223	34626947
Gait disturbance	35.59	10.84	608	173153	84532	34698638
Orbital myositis	35.53	10.84	16	173745	118	34783052
Plantar fasciitis	35.39	10.84	48	173713	2068	34781102
Cystitis	35.37	10.84	118	173643	9647	34773523
Prostatitis	35.35	10.84	82	173679	5425	34777745
Product use in unapproved indication	35.06	10.84	394	173367	117105	34666065
Hot flush	34.99	10.84	180	173581	17886	34765284
Muscular weakness	34.74	10.84	532	173229	72365	34710805
Peripheral swelling	34.73	10.84	554	173207	75987	34707183
Aspergillus infection	34.71	10.84	9	173752	12245	34770925
Product substitution issue	33.95	10.84	119	173642	9976	34773194
Oedema peripheral	33.88	10.84	807	172954	119005	34664165
Therapy non-responder	33.70	10.84	92	173669	39054	34744116
Erectile dysfunction	33.51	10.84	196	173565	20441	34762729
Sensation of foreign body	33.38	10.84	54	173707	2729	34780441
Chronic obstructive pulmonary disease	33.32	10.84	381	173380	48537	34734633
Urosepsis	33.27	10.84	139	173622	12660	34770510
Rectal prolapse	33.26	10.84	24	173737	468	34782702
Bladder spasm	33.13	10.84	31	173730	881	34782289
Plasma cell myeloma	33.08	10.84	337	173424	41700	34741470
Hepatic failure	32.95	10.84	77	173684	34454	34748716
Hepatotoxicity	32.77	10.84	35	173726	21450	34761720
Poisoning	32.73	10.84	10	173751	12216	34770954
Drug ineffective for unapproved indication	32.55	10.84	42	173719	23673	34759497
Haematoma	32.23	10.84	228	173533	25377	34757793
Dementia	31.69	10.84	144	173617	13604	34769566
Plasmapheresis	31.66	10.84	20	173741	310	34782860
Cataract	31.13	10.84	230	173531	25956	34757214
Nephrolithiasis	30.86	10.84	257	173504	30076	34753094
Seizure	30.73	10.84	353	173408	104504	34678666
Vitreous loss	30.61	10.84	8	173753	5	34783165
Stress	30.31	10.84	66	173695	30281	34752889
Pancytopenia	30.02	10.84	315	173446	94842	34688328
Febrile bone marrow aplasia	29.98	10.84	3	173758	8206	34774964
Gastrooesophageal reflux disease	29.82	10.84	304	173457	37620	34745550
Disseminated intravascular coagulation	29.57	10.84	39	173722	21777	34761393
Lower urinary tract symptoms	29.29	10.84	17	173744	224	34782946
Bronchiectasis	29.14	10.84	111	173650	9690	34773480
Hormone receptor positive breast cancer	29.14	10.84	10	173751	31	34783139
Haemophagocytic lymphohistiocytosis	29.11	10.84	14	173747	12959	34770211
Hepatic cytolysis	29.10	10.84	18	173743	14478	34768692
Full blood count decreased	28.86	10.84	171	173590	17917	34765253
Brain natriuretic peptide increased	28.68	10.84	77	173684	5582	34777588
Drug hypersensitivity	28.15	10.84	260	173501	80269	34702901
Contusion	27.88	10.84	290	173471	36074	34747096
Renal cyst haemorrhage	27.71	10.84	24	173737	615	34782555
Wheezing	27.54	10.84	321	173440	41081	34742089
Pancreatitis	27.43	10.84	100	173661	38791	34744379
Hepatic vein dilatation	27.24	10.84	16	173745	216	34782954
Pneumocystis jirovecii pneumonia	26.96	10.84	35	173726	19675	34763495
Loss of consciousness	26.87	10.84	568	173193	82099	34701071
Abdominal wall haemorrhage	26.68	10.84	21	173740	469	34782701
Muscle spasms	26.58	10.84	522	173239	74479	34708691
Hepatitis	26.43	10.84	49	173712	23855	34759315
Status epilepticus	26.25	10.84	15	173746	12599	34770571
Wound	25.99	10.84	144	173617	14720	34768450
Bladder catheterisation	25.89	10.84	22	173739	549	34782621
Intentional self-injury	25.11	10.84	19	173742	13752	34769418
Intraductal papillary mucinous neoplasm	25.06	10.84	21	173740	514	34782656
Prostatic mass	24.67	10.84	9	173752	35	34783135
Psychotic disorder	24.57	10.84	53	173708	24399	34758771
Intervertebral disc degeneration	24.55	10.84	79	173682	6338	34776832
Drug reaction with eosinophilia and systemic symptoms	24.54	10.84	83	173678	32929	34750241
Graft versus host disease	24.34	10.84	11	173750	10558	34772612
Infusion related reaction	24.31	10.84	159	173602	52898	34730272
Head injury	24.21	10.84	164	173597	17996	34765174
Blood bilirubin increased	24.12	10.84	103	173658	38193	34744977
Dacryocystitis	24.01	10.84	8	173753	22	34783148
Muscle spasticity	23.92	10.84	74	173687	5814	34777356
Sleep apnoea syndrome	23.88	10.84	178	173583	20143	34763027
Atrial septal defect	23.88	10.84	4	173757	7388	34775782
Acute hepatic failure	23.69	10.84	21	173740	14053	34769117
Haematotoxicity	23.24	10.84	6	173755	8188	34774982
Blood phosphorus increased	23.19	10.84	5	173756	7716	34775454
Hepatic function abnormal	22.92	10.84	128	173633	44235	34738935
Brain oedema	22.82	10.84	21	173740	13800	34769370
Appendicitis	22.71	10.84	24	173737	14783	34768387
Cytokine release syndrome	22.64	10.84	50	173711	22827	34760343
Aplastic anaemia	22.55	10.84	10	173751	9706	34773464
Factitious disorder	22.41	10.84	9	173752	48	34783122
Radiation inflammation	22.38	10.84	25	173736	880	34782290
Aspartate aminotransferase increased	22.35	10.84	222	173539	67561	34715609
Micturition disorder	22.19	10.84	40	173721	2208	34780962
Device dislocation	22.18	10.84	75	173686	6174	34776996
Immune reconstitution inflammatory syndrome	21.99	10.84	8	173753	8751	34774419
Cytomegalovirus viraemia	21.94	10.84	5	173756	7425	34775745
Platypnoea	21.76	10.84	8	173753	32	34783138
Candida infection	21.71	10.84	34	173727	17681	34765489
Vena cava injury	21.66	10.84	16	173745	324	34782846
Transaminases increased	21.65	10.84	65	173696	26758	34756412
Malignant spinal cord compression	21.58	10.84	12	173749	145	34783025
Palpitations	21.48	10.84	298	173463	39688	34743482
Diastolic dysfunction	21.46	10.84	74	173687	6153	34777017
Chest X-ray abnormal	21.44	10.84	59	173702	4339	34778831
Arteriovenous fistula	21.37	10.84	27	173734	1084	34782086
Liver palpable	21.30	10.84	15	173746	281	34782889
Agranulocytosis	21.25	10.84	55	173706	23766	34759404
Bronchopulmonary aspergillosis	21.13	10.84	25	173736	14634	34768536
Akathisia	21.06	10.84	7	173754	8102	34775068
Milk-alkali syndrome	20.90	10.84	20	173741	585	34782585
SARS-CoV-2 antibody test positive	20.60	10.84	17	173744	407	34782763
Intentional product misuse	20.23	10.84	138	173623	45473	34737697
Malignant melanoma in situ	20.01	10.84	33	173728	1695	34781475
Monoparesis	19.75	10.84	39	173722	2307	34780863
Adverse drug reaction	19.73	10.84	228	173533	29114	34754056
Idiopathic interstitial pneumonia	19.63	10.84	12	173749	175	34782995
Peritonitis	19.50	10.84	32	173729	16333	34766837
Asthma	19.43	10.84	309	173452	42347	34740823
Lymphopenia	19.41	10.84	32	173729	16303	34766867
Vascular anastomotic haemorrhage	19.40	10.84	14	173747	273	34782897
Hepatomegaly	19.40	10.84	14	173747	10382	34772788
Tachyarrhythmia	19.20	10.84	50	173711	3558	34779612
C-reactive protein increased	19.19	10.84	174	173587	53924	34729246
Intestinal haemorrhage	19.18	10.84	49	173712	3447	34779723
Serum ferritin abnormal	19.15	10.84	13	173748	229	34782941
Post micturition dribble	19.00	10.84	6	173755	13	34783157
Thrombotic microangiopathy	18.96	10.84	15	173746	10615	34772555
Breath sounds abnormal	18.89	10.84	76	173685	6805	34776365
Perineal pain	18.89	10.84	22	173739	811	34782359
BK virus infection	18.77	10.84	3	173758	5735	34777435
Pathogen resistance	18.72	10.84	12	173749	9470	34773700
Diverticulum intestinal	18.68	10.84	53	173708	3968	34779202
Subdural haematoma	18.67	10.84	169	173592	20252	34762918
Hip fracture	18.55	10.84	112	173649	11813	34771357
Cystitis haemorrhagic	18.51	10.84	3	173758	5676	34777494
Bladder discomfort	18.50	10.84	11	173750	152	34783018
Testicular infarction	18.36	10.84	8	173753	54	34783116
Respiratory depression	18.23	10.84	33	173728	16212	34766958
Flatulence	18.16	10.84	173	173588	21025	34762145
Vascular compression	18.11	10.84	15	173746	361	34782809
Post transplant lymphoproliferative disorder	18.10	10.84	5	173756	6523	34776647
Product use issue	18.05	10.84	214	173547	63002	34720168
Cornea verticillata	18.00	10.84	8	173753	57	34783113
Septic shock	17.98	10.84	250	173511	71584	34711586
Testicular swelling	17.95	10.84	31	173730	1654	34781516
Pain in extremity	17.80	10.84	784	172977	125729	34657441
Perineal cyst	17.78	10.84	13	173748	259	34782911
Stomatitis	17.70	10.84	131	173630	42383	34740787
Dizziness postural	17.66	10.84	69	173692	6095	34777075
Iris haemorrhage	17.63	10.84	5	173756	6	34783164
Nephropathy toxic	17.58	10.84	22	173739	12566	34770604
Mydriasis	17.52	10.84	7	173754	7230	34775940
Extrapyramidal disorder	17.48	10.84	23	173738	12857	34770313
Neutrophil count decreased	17.42	10.84	166	173595	50938	34732232
Diabetes mellitus	17.40	10.84	149	173612	46724	34736446
Wrong schedule	17.27	10.84	11	173750	173	34782997
Urinary hesitation	17.20	10.84	41	173720	2761	34780409
Haematospermia	17.18	10.84	14	173747	329	34782841
Platelet distribution width increased	17.09	10.84	10	173751	134	34783036
Tongue dry	16.90	10.84	12	173749	228	34782942
Poisoning deliberate	16.80	10.84	9	173752	7835	34775335
Spinal stenosis	16.77	10.84	61	173700	5208	34777962
Bladder neck obstruction	16.65	10.84	10	173751	141	34783029
Adenovirus infection	16.64	10.84	3	173758	5254	34777916
Prostatic operation	16.55	10.84	15	173746	409	34782761
Hepatic enzyme increased	16.47	10.84	120	173641	38960	34744210
Bladder pain	16.47	10.84	17	173744	546	34782624
Fluid intake reduced	16.43	10.84	48	173713	3653	34779517
Phaeochromocytoma malignant	16.41	10.84	8	173753	72	34783098
Acute graft versus host disease in skin	16.39	10.84	3	173758	5198	34777972
Hyponatraemic syndrome	16.39	10.84	11	173750	190	34782980
Diabetic neuropathy	16.36	10.84	52	173709	4145	34779025
Puncture site haematoma	16.29	10.84	10	173751	147	34783023
Respiratory distress	16.27	10.84	107	173654	35558	34747612
Cardiac disorder	16.24	10.84	303	173458	42823	34740347
Drug eruption	16.21	10.84	48	173713	19850	34763320
Prostate cancer	16.14	10.84	282	173479	39367	34743803
Gait inability	16.13	10.84	166	173595	20592	34762578
Loss of personal independence in daily activities	16.12	10.84	243	173518	32936	34750234
Urinary tract obstruction	16.12	10.84	47	173714	3573	34779597
Dysgeusia	16.11	10.84	202	173559	26295	34756875
Rapid eye movement sleep behaviour disorder	16.11	10.84	10	173751	150	34783020
Gout	15.94	10.84	156	173605	19097	34764073
Herpes simplex	15.90	10.84	4	173757	5555	34777615
Venoocclusive liver disease	15.84	10.84	10	173751	7956	34775214
Carotid arteriosclerosis	15.78	10.84	31	173730	1827	34781343
Atrioventricular block first degree	15.71	10.84	66	173695	6026	34777144
Blood glucose fluctuation	15.67	10.84	50	173711	3994	34779176
Genital swelling	15.66	10.84	10	173751	158	34783012
Lacunar stroke	15.62	10.84	11	173750	206	34782964
Dacryostenosis acquired	15.59	10.84	12	173749	259	34782911
Sedation	15.48	10.84	53	173708	20953	34762217
Back pain	15.46	10.84	747	173014	121042	34662128
Resting tremor	15.44	10.84	18	173743	664	34782506
Posterior reversible encephalopathy syndrome	15.42	10.84	16	173745	9938	34773232
Narrow anterior chamber angle	15.42	10.84	9	173752	120	34783050
Dysphonia	15.41	10.84	181	173580	23202	34759968
Colitis	15.39	10.84	117	173644	37633	34745537
Nipple pain	15.29	10.84	21	173740	916	34782254
Klebsiella infection	15.26	10.84	12	173749	8519	34774651
Breast tenderness	15.25	10.84	19	173742	752	34782418
Secretion discharge	15.25	10.84	64	173697	5841	34777329
Bladder outlet obstruction	15.24	10.84	10	173751	166	34783004
Blood urine present	15.14	10.84	99	173662	10735	34772435
Iris atrophy	15.11	10.84	8	173753	87	34783083
Prostatic obstruction	15.04	10.84	9	173752	126	34783044
Myocardial infarction	14.95	10.84	473	173288	120612	34662558
Periorbital haematoma	14.89	10.84	13	173748	337	34782833
Granulocytopenia	14.87	10.84	7	173754	6560	34776610
Multiple sclerosis relapse	14.84	10.84	114	173647	13019	34770151
Drug level increased	14.81	10.84	58	173703	22038	34761132
Renal failure	14.71	10.84	516	173245	130041	34653129
Psoriatic arthropathy	14.56	10.84	50	173711	19748	34763422
Condition aggravated	14.54	10.84	794	172967	191402	34591768
Transient ischaemic attack	14.51	10.84	205	173556	27408	34755762
Benign gastrointestinal neoplasm	14.44	10.84	9	173752	136	34783034
Stomal hernia	14.23	10.84	11	173750	239	34782931
Disease progression	14.12	10.84	419	173342	107658	34675512
Hyperammonaemia	14.09	10.84	7	173754	6360	34776810
Liver disorder	14.06	10.84	101	173660	32896	34750274
Burning feet syndrome	14.01	10.84	8	173753	102	34783068
Insomnia	13.97	10.84	641	173120	103266	34679904
Aggression	13.96	10.84	125	173636	38839	34744331
Umbilical hernia	13.93	10.84	53	173708	4624	34778546
Aortic dilatation	13.92	10.84	25	173736	1376	34781794
Inferior vena cava dilatation	13.88	10.84	18	173743	742	34782428
Renal haematoma	13.75	10.84	15	173746	514	34782656
Ageusia	13.68	10.84	93	173668	10215	34772955
Pulmonary pain	13.67	10.84	23	173738	1201	34781969
Sepsis	13.56	10.84	683	173078	165878	34617292
Arteriosclerotic gangrene	13.56	10.84	7	173754	72	34783098
Hallucination, auditory	13.56	10.84	24	173737	11893	34771277
Pharyngeal cancer	13.47	10.84	6	173755	43	34783127
Acute respiratory distress syndrome	13.37	10.84	75	173686	25894	34757276
Dysstasia	13.31	10.84	105	173656	12090	34771080
Coagulopathy	13.22	10.84	52	173709	19737	34763433
Injection site pain	13.17	10.84	127	173634	38878	34744292
Toxic epidermal necrolysis	13.15	10.84	59	173702	21587	34761583
Pseudomonas infection	13.15	10.84	26	173735	12356	34770814
Urinary tract disorder	13.07	10.84	32	173729	2192	34780978
Dental restoration failure	13.05	10.84	5	173756	23	34783147
Tuberculosis	13.05	10.84	14	173747	8563	34774607
Faeces discoloured	13.03	10.84	122	173639	14756	34768414
Mean cell volume increased	13.03	10.84	40	173721	3129	34780041
Femoral artery aneurysm	12.99	10.84	9	173752	164	34783006
Tubulointerstitial nephritis	12.96	10.84	57	173704	20967	34762203
Hydronephrosis	12.94	10.84	92	173669	10254	34772916
Vertigo CNS origin	12.93	10.84	3	173758	0	34783170
Iris injury	12.93	10.84	3	173758	0	34783170
Subdural hygroma	12.91	10.84	12	173749	338	34782832
Kidney transplant rejection	12.85	10.84	11	173750	7486	34775684
Cardiotoxicity	12.82	10.84	6	173755	5642	34777528
Bladder dysfunction	12.80	10.84	12	173749	342	34782828
Pemphigoid	12.61	10.84	80	173681	8586	34774584
Pulmonary tuberculosis	12.53	10.84	4	173757	4750	34778420
Tendon pain	12.50	10.84	38	173723	2957	34780213
Obsessive-compulsive disorder	12.49	10.84	6	173755	5558	34777612
Troponin increased	12.39	10.84	98	173663	11291	34771879
Oesophageal rupture	12.38	10.84	13	173748	426	34782744
Abnormal dreams	12.32	10.84	72	173689	7506	34775664
Serotonin syndrome	12.31	10.84	54	173707	19879	34763291
Rheumatoid arthritis	12.28	10.84	126	173635	38112	34745058
Migraine	12.28	10.84	45	173716	17433	34765737
Alanine aminotransferase abnormal	12.26	10.84	4	173757	4684	34778486
Oesophageal carcinoma	12.24	10.84	17	173744	9287	34773883
Paraplegia	12.21	10.84	37	173724	2874	34780296
Musculoskeletal stiffness	12.21	10.84	161	173600	46519	34736651
Palatal oedema	12.11	10.84	18	173743	845	34782325
Cardiac amyloidosis	12.02	10.84	22	173739	1229	34781941
Suprapubic pain	12.00	10.84	13	173748	442	34782728
Hepatic fibrosis	11.92	10.84	4	173757	4603	34778567
Anaphylactic reaction	11.84	10.84	103	173658	32198	34750972
Uveitis	11.80	10.84	12	173749	7523	34775647
Inadequate osteointegration	11.75	10.84	4	173757	12	34783158
Cyanosis	11.75	10.84	29	173732	12735	34770435
Drug level decreased	11.72	10.84	13	173748	7833	34775337
Wound haematoma	11.68	10.84	6	173755	61	34783109
Taste disorder	11.64	10.84	68	173693	7087	34776083
Arrhythmia	11.61	10.84	246	173515	35562	34747608
Acidosis	11.61	10.84	23	173738	10922	34772248
Tendon discomfort	11.56	10.84	10	173751	256	34782914
Movement disorder	11.52	10.84	102	173659	12146	34771024
Transplant rejection	11.52	10.84	21	173740	10290	34772880
Pulmonary haemorrhage	11.50	10.84	21	173740	10283	34772887
Intestinal perforation	11.48	10.84	17	173744	9043	34774127
Pneumonia fungal	11.47	10.84	11	173750	7089	34776081
Restless legs syndrome	11.47	10.84	76	173685	8278	34774892
Blood 25-hydroxycholecalciferol decreased	11.46	10.84	10	173751	259	34782911
Renal cyst	11.46	10.84	81	173680	9012	34774158
Sickle cell anaemia with crisis	11.43	10.84	3	173758	4050	34779120
Injection site erosion	11.39	10.84	7	173754	103	34783067
Urethral pain	11.39	10.84	7	173754	103	34783067
Inappropriate antidiuretic hormone secretion	11.38	10.84	105	173656	12648	34770522
Prostatism	11.36	10.84	10	173751	262	34782908
Angina pectoris	11.34	10.84	219	173542	31144	34752026
Macular degeneration	11.33	10.84	30	173731	2156	34781014
Neurosurgery	11.32	10.84	5	173756	35	34783135
Acquired haemophilia	11.31	10.84	19	173742	991	34782179
Product size issue	11.30	10.84	16	173745	718	34782452
Calculus bladder	11.28	10.84	19	173742	993	34782177
Blood creatine phosphokinase increased	11.26	10.84	156	173605	44701	34738469
Swelling of eyelid	11.26	10.84	20	173741	1091	34782079
Pruritus	11.22	10.84	835	172926	141146	34642024
Diarrhoea	11.21	10.84	2149	171612	387763	34395407
Urinary bladder haemorrhage	11.18	10.84	26	173735	1723	34781447
Skin laceration	11.17	10.84	103	173658	12406	34770764
Respiratory failure	11.13	10.84	434	173327	108138	34675032
Rib fracture	11.11	10.84	115	173646	14285	34768885
Alveolar bone resorption	11.08	10.84	4	173757	15	34783155
Accidental exposure to product	11.08	10.84	30	173731	12772	34770398
Blood pressure systolic	11.08	10.84	4	173757	15	34783155
Aortic stenosis	11.07	10.84	47	173714	4311	34778859
Substance abuse	11.05	10.84	13	173748	7628	34775542
Suicidal ideation	11.04	10.84	138	173623	40250	34742920
Delayed graft function	11.03	10.84	30	173731	2191	34780979
Choroidal detachment	11.03	10.84	12	173749	410	34782760
Atrial enlargement	10.87	10.84	15	173746	657	34782513
Gastrointestinal bacterial infection	10.86	10.84	12	173749	417	34782753
Anorectal operation	10.86	10.84	3	173758	3	34783167
Sperm concentration zero	10.86	10.84	3	173758	3	34783167

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Iris disorder	538.91	10.13	128	150187	245	79593828
Urinary retention	472.31	10.13	558	149757	56072	79538001
Syncope	356.12	10.13	936	149379	178513	79415560
Benign prostatic hyperplasia	330.67	10.13	229	150086	11383	79582690
Fall	315.40	10.13	1776	148539	485853	79108220
Drug ineffective	280.84	10.13	1071	149244	1079842	78514231
Haematuria	278.08	10.13	480	149835	68356	79525717
Dizziness	268.21	10.13	1803	148512	524638	79069435
Orthostatic hypotension	266.37	10.13	421	149894	55743	79538330
Atrial fibrillation	254.38	10.13	886	149429	197000	79397073
Synovitis	244.31	10.13	9	150306	150725	79443348
Product prescribing error	237.96	10.13	354	149961	44459	79549614
Maternal exposure during pregnancy	236.93	10.13	4	150311	136534	79457539
Idiopathic pulmonary fibrosis	216.15	10.13	121	150194	4107	79589966
Drug intolerance	211.91	10.13	117	150198	264002	79330071
Cataract operation complication	206.34	10.13	57	150258	244	79593829
Alopecia	196.70	10.13	95	150220	231260	79362813
Dysuria	184.79	10.13	339	149976	50612	79543461
Treatment failure	171.28	10.13	54	150261	170432	79423641
Joint swelling	171.03	10.13	175	150140	288471	79305602
Iridocele	170.99	10.13	36	150279	25	79594048
Nocturia	167.10	10.13	165	150150	13516	79580557
Micturition urgency	157.26	10.13	154	150161	12487	79581586
Bradycardia	157.11	10.13	587	149728	134970	79459103
Hypotension	153.66	10.13	1382	148933	438935	79155138
Rheumatoid arthritis	152.32	10.13	103	150212	208367	79385706
Systemic lupus erythematosus	148.20	10.13	25	150290	121124	79472949
Pollakiuria	138.75	10.13	251	150064	37066	79557007
Pemphigus	137.47	10.13	14	150301	99568	79494505
Drug hypersensitivity	133.21	10.13	224	150091	298692	79295381
Erectile dysfunction	131.39	10.13	150	150165	14514	79579559
Floppy iris syndrome	123.42	10.13	40	150275	323	79593750
Death	121.96	10.13	1615	148700	564899	79029174
Arthropathy	120.90	10.13	94	150221	177017	79417056
Toxicity to various agents	120.56	10.13	400	149915	421140	79172933
Pericarditis	115.99	10.13	27	150288	104209	79489864
Glossodynia	114.53	10.13	27	150288	103310	79490763
Right atrial hypertrophy	114.38	10.13	46	150269	725	79593348
Hallucination	112.70	10.13	387	149928	85358	79508715
Infusion related reaction	111.61	10.13	163	150152	230074	79363999
Drug abuse	111.49	10.13	86	150229	162605	79431468
Procedural complication	110.20	10.13	103	150212	7880	79586193
Hepatic enzyme increased	110.06	10.13	109	150206	182501	79411572
Urinary incontinence	109.69	10.13	240	150075	40669	79553404
Therapeutic product effect decreased	109.29	10.13	89	150226	163774	79430299
Discomfort	107.60	10.13	51	150264	125566	79468507
Asthenia	106.87	10.13	1451	148864	510238	79083835
Prostatic specific antigen increased	106.46	10.13	114	150201	10272	79583801
Product monitoring error	106.15	10.13	106	150209	8800	79585273
Priapism	105.71	10.13	79	150236	4426	79589647
Prostate cancer	105.38	10.13	209	150106	33059	79561014
Hypersensitivity	104.81	10.13	210	150105	262029	79332044
General physical health deterioration	101.58	10.13	875	149440	274363	79319710
Presyncope	96.91	10.13	229	150086	40825	79553248
Sinusitis	96.13	10.13	137	150178	195364	79398709
Labelled drug-drug interaction medication error	95.27	10.13	180	150135	27470	79566603
Arthralgia	95.20	10.13	659	149656	571144	79022929
Congenital hiatus hernia	91.50	10.13	40	150275	784	79593289
Urogenital haemorrhage	91.18	10.13	42	150273	935	79593138
Prostatomegaly	90.60	10.13	65	150250	3418	79590655
Pain	89.85	10.13	871	149444	702931	78891142
Right ventricular hypertrophy	89.58	10.13	49	150266	1588	79592485
Fibromyalgia	88.91	10.13	9	150306	64331	79529742
Nephrolithiasis	85.90	10.13	258	150057	53033	79541040
Completed suicide	85.75	10.13	212	150103	245555	79348518
Acute kidney injury	85.09	10.13	1413	148902	517991	79076082
Urinary tract infection	83.80	10.13	838	149477	273674	79320399
Confusional state	83.19	10.13	941	149374	317056	79277017
Prostatitis	81.86	10.13	66	150249	4136	79589937
Helicobacter infection	81.74	10.13	16	150299	69688	79524385
Haematochezia	78.08	10.13	350	149965	87295	79506778
Dyspnoea	77.56	10.13	2138	148177	854887	78739186
Stomatitis	77.04	10.13	98	150217	146659	79447414
Needle fatigue	75.60	10.13	36	150279	866	79593207
Musculoskeletal stiffness	74.39	10.13	135	150180	174873	79419200
Swelling	73.22	10.13	190	150125	216521	79377552
Pulmonary function test abnormal	70.15	10.13	60	150255	4084	79589989
Gait spastic	65.97	10.13	36	150279	1161	79592912
Headache	65.62	10.13	854	149461	652918	78941155
Contraindicated product administered	64.76	10.13	124	150191	157414	79436659
Folliculitis	64.34	10.13	13	150302	55367	79538706
Hypertonic bladder	63.44	10.13	57	150258	4144	79589929
Aortic valve stenosis	63.08	10.13	63	150252	5231	79588842
Off label use	62.57	10.13	1271	149044	905944	78688129
Anaemia	61.91	10.13	1180	149135	443835	79150238
Bronchial wall thickening	61.27	10.13	46	150269	2595	79591478
Subdural haematoma	61.24	10.13	163	150152	31271	79562802
Obstruction	58.91	10.13	57	150258	4553	79589520
Irritable bowel syndrome	58.53	10.13	22	150293	62219	79531854
Vomiting	58.22	10.13	894	149421	664934	78929139
Relapsing-remitting multiple sclerosis	58.00	10.13	36	150279	1483	79592590
Plasma cell myeloma	57.83	10.13	226	150089	53033	79541040
Systemic infection	56.05	10.13	80	150235	9672	79584401
Drug resistance	55.57	10.13	7	150308	42206	79551867
Oedema peripheral	55.23	10.13	722	149593	251566	79342507
Muscle injury	55.18	10.13	12	150303	48549	79545524
Psoriatic arthropathy	54.99	10.13	40	150275	77959	79516114
Pupillary disorder	54.50	10.13	25	150290	551	79593522
Injection site pain	53.54	10.13	102	150213	129736	79464337
Intentional overdose	53.31	10.13	73	150242	105887	79488186
Migraine	52.94	10.13	52	150263	87441	79506632
Chronic obstructive pulmonary disease	52.86	10.13	308	150007	85111	79508962
Dyspnoea exertional	51.97	10.13	311	150004	86762	79507311
Retrograde ejaculation	50.94	10.13	20	150295	295	79593778
Gout	49.90	10.13	130	150185	24619	79569454
Bronchial secretion retention	49.19	10.13	49	150266	4055	79590018
Injection site erythema	47.87	10.13	46	150269	78151	79515922
Renal cyst haemorrhage	47.20	10.13	24	150291	668	79593405
Loss of consciousness	47.07	10.13	504	149811	167439	79426634
Lower respiratory tract infection	46.99	10.13	109	150206	129111	79464962
Nasopharyngitis	46.49	10.13	284	150031	253597	79340476
Abdominal discomfort	46.16	10.13	280	150035	250447	79343626
Orbital myositis	45.74	10.13	16	150299	167	79593906
Cerebral haemorrhage	45.26	10.13	222	150093	57451	79536622
Hospice care	44.31	10.13	74	150241	10250	79583823
Pneumonia	44.19	10.13	1589	148726	658657	78935416
Haematoma	43.92	10.13	205	150110	51990	79542083
Radiation inflammation	43.83	10.13	25	150290	880	79593193
Lower urinary tract symptoms	43.51	10.13	16	150299	195	79593878
Hydronephrosis	42.98	10.13	99	150216	17355	79576718
Infection	42.90	10.13	273	150042	241439	79352634
Bladder cancer	41.89	10.13	105	150210	19421	79574652
Impaired healing	41.52	10.13	63	150252	87592	79506481
Drug interaction	41.46	10.13	1050	149265	414133	79179940
Dehydration	40.07	10.13	674	149641	247513	79346560
Nausea	39.98	10.13	1440	148875	955756	78638317
Suicide attempt	39.87	10.13	59	150256	82873	79511200
Bronchiectasis	39.54	10.13	112	150203	22274	79571799
Muscular weakness	39.44	10.13	470	149845	160259	79433814
Interstitial lung disease	39.40	10.13	354	149961	112246	79481827
Dementia	39.37	10.13	119	150196	24540	79569533
Angina pectoris	39.08	10.13	197	150118	51535	79542538
Urine flow decreased	38.88	10.13	25	150290	1096	79592977
Urosepsis	38.73	10.13	124	150191	26371	79567702
Hypoacusis	38.65	10.13	135	150180	30015	79564058
Multiple organ dysfunction syndrome	38.64	10.13	108	150207	120138	79473935
Abdominal wall haemorrhage	38.60	10.13	21	150294	673	79593400
Miosis	38.27	10.13	89	150226	15700	79578373
Vertigo	38.24	10.13	242	150073	68840	79525233
Hepatic vein dilatation	37.50	10.13	15	150300	233	79593840
Breast cancer	37.08	10.13	9	150306	33772	79560301
Constipation	37.07	10.13	744	149571	282306	79311767
Cardiac failure congestive	36.98	10.13	421	149894	141981	79452092
Arteriovenous fistula	36.90	10.13	26	150289	1328	79592745
Diastolic dysfunction	36.77	10.13	70	150245	10741	79583332
Therapy non-responder	36.76	10.13	74	150241	92231	79501842
Pemphigoid	36.76	10.13	86	150229	15229	79578844
Product use issue	36.71	10.13	238	150077	209584	79384489
Ill-defined disorder	36.67	10.13	42	150273	65833	79528240
Injection site pruritus	36.45	10.13	17	150298	42266	79551807
Injection site reaction	36.20	10.13	30	150285	54755	79539318
Vena cava injury	35.59	10.13	16	150299	336	79593737
SARS-CoV-2 antibody test positive	35.21	10.13	17	150298	422	79593651
Balance disorder	35.21	10.13	312	150003	98545	79495528
Myelosuppression	35.05	10.13	16	150299	40280	79553793
Ejaculation failure	35.03	10.13	16	150299	349	79593724
Device expulsion	34.75	10.13	4	150311	25857	79568216
Intentional product use issue	34.03	10.13	159	150156	151953	79442120
Abdominal pain lower	33.80	10.13	134	150181	31648	79562425
Plasmapheresis	33.80	10.13	19	150296	650	79593423
Product substitution issue	33.52	10.13	99	150216	20157	79573916
Monoparesis	33.30	10.13	37	150278	3474	79590599
Intraductal papillary mucinous neoplasm	33.26	10.13	20	150295	778	79593295
Head injury	33.09	10.13	149	150166	37220	79556853
Testicular swelling	33.05	10.13	24	150291	1286	79592787
Troponin increased	32.72	10.13	95	150220	19160	79574913
Malignant melanoma in situ	32.62	10.13	31	150284	2421	79591652
Full blood count abnormal	32.62	10.13	157	150158	40317	79553756
Malignant spinal cord compression	32.58	10.13	12	150303	147	79593926
Perineal pain	32.36	10.13	22	150293	1060	79593013
Arrhythmia	32.29	10.13	212	150103	61060	79533013
Upper gastrointestinal haemorrhage	32.26	10.13	159	150156	41221	79552852
Gastrointestinal disorder	32.14	10.13	120	150195	122085	79471988
Vascular anastomotic haemorrhage	32.09	10.13	14	150301	273	79593800
Rectal haemorrhage	32.08	10.13	250	150065	76050	79518023
Liver palpable	32.08	10.13	15	150300	346	79593727
Chest X-ray abnormal	31.84	10.13	55	150260	7828	79586245
Inflammation	31.79	10.13	82	150233	93671	79500402
Respiratory arrest	31.70	10.13	37	150278	57513	79536560
Injection site swelling	30.91	10.13	26	150289	47106	79546967
Micturition disorder	30.79	10.13	38	150277	3990	79590083
Umbilical hernia	30.76	10.13	46	150269	5799	79588274
Vitreous loss	30.74	10.13	7	150308	10	79594063
Cerebrovascular accident	30.50	10.13	436	149879	154856	79439217
Prostatic mass	30.34	10.13	7	150308	11	79594062
Urinary tract obstruction	30.24	10.13	41	150274	4724	79589349
Drug dependence	29.94	10.13	20	150295	40749	79553324
Cytomegalovirus infection	29.89	10.13	22	150293	42622	79551451
Blister	29.70	10.13	120	150195	119356	79474717
Perineal cyst	29.68	10.13	13	150302	256	79593817
Platypnoea	29.39	10.13	8	150307	32	79594041
Bladder neck obstruction	29.06	10.13	10	150305	99	79593974
Tendon pain	29.03	10.13	44	150271	5614	79588459
Cardiac failure	28.94	10.13	431	149884	154411	79439662
Urticaria	28.51	10.13	218	150097	184983	79409090
Transient ischaemic attack	28.18	10.13	183	150132	52512	79541561
Prostatic disorder	28.15	10.13	27	150288	2133	79591940
Bladder catheterisation	28.15	10.13	19	150296	905	79593168
Blood cholesterol increased	27.79	10.13	74	150241	83646	79510427
Idiopathic interstitial pneumonia	27.69	10.13	12	150303	230	79593843
Urinary hesitation	27.52	10.13	37	150278	4229	79589844
Hepatotoxicity	27.24	10.13	34	150281	51318	79542755
Red blood cell sedimentation rate increased	27.00	10.13	28	150287	45914	79548159
Carotid arteriosclerosis	26.95	10.13	29	150286	2627	79591446
Guillain-Barre syndrome	26.81	10.13	55	150260	8910	79585163
Hyponatraemia	26.53	10.13	477	149838	177371	79416702
Haemoglobin decreased	26.51	10.13	576	149739	221543	79372530
Haematospermia	26.43	10.13	12	150303	258	79593815
Ejaculation disorder	26.40	10.13	15	150300	524	79593549
Weight increased	26.40	10.13	366	149949	277020	79317053
Renal impairment	26.37	10.13	431	149884	157352	79436721
Platelet distribution width increased	26.27	10.13	10	150305	135	79593938
Prostate cancer metastatic	26.22	10.13	35	150280	3972	79590101
Intestinal haemorrhage	26.18	10.13	45	150270	6381	79587692
Tachyarrhythmia	26.09	10.13	47	150268	6915	79587158
Testicular infarction	25.93	10.13	8	150307	54	79594019
Faeces discoloured	25.69	10.13	116	150199	29011	79565062
Delirium	25.60	10.13	258	150057	84369	79509704
Vascular compression	25.52	10.13	15	150300	559	79593514
Obstructive airways disorder	25.33	10.13	122	150193	31337	79562736
Dacryocystitis	25.32	10.13	8	150307	59	79594014
Stress	25.21	10.13	72	150243	79540	79514533
Gastrointestinal haemorrhage	24.86	10.13	404	149911	147315	79446758
Inguinal hernia	24.57	10.13	44	150271	6444	79587629
Pallor	24.45	10.13	170	150145	49892	79544181
Inferior vena cava dilatation	24.38	10.13	17	150298	854	79593219
Aortic dilatation	24.28	10.13	23	150292	1789	79592284
Phaeochromocytoma malignant	23.92	10.13	8	150307	72	79594001
Puncture site haematoma	23.91	10.13	10	150305	175	79593898
Poisoning	23.64	10.13	9	150306	25263	79568810
Residual urine volume increased	23.53	10.13	7	150308	41	79594032
Mucosal inflammation	23.46	10.13	69	150246	75511	79518562
Arthritis	23.44	10.13	124	150191	114756	79479317
COVID-19 pneumonia	23.31	10.13	112	150203	28737	79565336
Mean cell volume increased	23.16	10.13	42	150273	6211	79587862
Milk-alkali syndrome	22.90	10.13	20	150295	1400	79592673
Gynaecomastia	22.82	10.13	47	150268	7634	79586439
Bladder spasm	22.76	10.13	25	150290	2318	79591755
Ageusia	22.66	10.13	76	150239	16556	79577517
Benign gastrointestinal neoplasm	22.49	10.13	9	150306	140	79593933
Rectal prolapse	22.49	10.13	24	150291	2154	79591919
Hyperkalaemia	22.38	10.13	321	149994	114077	79479996
Wound	22.28	10.13	128	150187	116051	79478022
Diabetic neuropathy	22.07	10.13	41	150274	6175	79587898
Delayed graft function	21.99	10.13	30	150285	3477	79590596
Hip arthroplasty	21.92	10.13	21	150294	35735	79558338
Factitious disorder	21.81	10.13	9	150306	152	79593921
Breath sounds abnormal	21.74	10.13	73	150242	15911	79578162
Condition aggravated	21.71	10.13	750	149565	500374	79093699
Paraplegia	21.39	10.13	36	150279	5017	79589056
Serum ferritin abnormal	21.33	10.13	12	150303	411	79593662
Mantle cell lymphoma	21.25	10.13	19	150296	1372	79592701
Blood pressure decreased	21.04	10.13	283	150032	99183	79494890
Renal haematoma	20.72	10.13	15	150300	800	79593273
Inappropriate antidiuretic hormone secretion	20.43	10.13	101	150214	26212	79567861
Therapy partial responder	20.38	10.13	4	150311	17393	79576680
Prostatic operation	20.29	10.13	10	150305	260	79593813
Arteriosclerotic gangrene	19.93	10.13	7	150308	74	79593999
Intentional self-injury	19.92	10.13	19	150296	32400	79561673
Squamous cell carcinoma of skin	19.90	10.13	65	150250	13968	79580105
Flushing	19.89	10.13	92	150223	88176	79505897
Ventricular enlargement	19.82	10.13	14	150301	718	79593355
Resting tremor	19.80	10.13	19	150296	1502	79592571
Coma	19.78	10.13	110	150205	100539	79493534
Wrong patient received product	19.68	10.13	33	150282	4585	79589488
Atrioventricular block first degree	19.68	10.13	60	150255	12431	79581642
Scrotal infection	19.62	10.13	13	150302	600	79593473
Drug ineffective for unapproved indication	19.62	10.13	42	150273	51196	79542877
Haemoptysis	19.55	10.13	176	150139	55823	79538250
Pulmonary vasculitis	19.33	10.13	14	150301	747	79593326
Subdural hygroma	19.28	10.13	12	150303	497	79593576
Acute hepatic failure	19.27	10.13	17	150298	30096	79563977
Osteoarthritis	19.09	10.13	92	150223	87217	79506856
Aortic stenosis	18.99	10.13	43	150272	7452	79586621
Gait disturbance	18.99	10.13	519	149796	206987	79387086
Blood glucose fluctuation	18.82	10.13	40	150275	6642	79587431
Intervertebral disc degeneration	18.80	10.13	69	150246	15716	79578357
Lower gastrointestinal haemorrhage	18.80	10.13	70	150245	16055	79578018
Foot deformity	18.79	10.13	11	150304	24063	79570010
Mydriasis	18.79	10.13	5	150310	17638	79576435
Joint range of motion decreased	18.76	10.13	21	150294	33261	79560812
Hepatitis	18.69	10.13	49	150266	55678	79538395
Dizziness postural	18.69	10.13	56	150259	11493	79582580
Sedation	18.68	10.13	44	150271	51851	79542222
Therapeutic response decreased	18.67	10.13	64	150251	66789	79527284
Perineal infection	18.60	10.13	14	150301	793	79593280
Injury	18.53	10.13	79	150236	77417	79516656
Genital swelling	18.40	10.13	10	150305	320	79593753
Testicular pain	18.29	10.13	21	150294	2044	79592029
Diverticulum intestinal	18.17	10.13	46	150269	8559	79585514
Central nervous system lesion	18.13	10.13	61	150254	13307	79580766
Fluid intake reduced	18.13	10.13	38	150277	6250	79587823
Liver injury	18.07	10.13	51	150264	56563	79537510
Orchitis	17.93	10.13	17	150298	1324	79592749
Acquired haemophilia	17.89	10.13	20	150295	1891	79592182
Pharyngeal cancer	17.75	10.13	6	150309	56	79594017
Bladder tamponade	17.62	10.13	12	150303	580	79593493
Thermal burns of eye	17.54	10.13	7	150308	108	79593965
Narrow anterior chamber angle	17.54	10.13	8	150307	174	79593899
Atrial enlargement	17.45	10.13	15	150300	1028	79593045
Hormone receptor positive breast cancer	17.40	10.13	10	150305	357	79593716
Internal haemorrhage	17.40	10.13	46	150269	8787	79585286
Wrong schedule	17.35	10.13	10	150305	359	79593714
Bladder obstruction	17.34	10.13	11	150304	471	79593602
Haematotoxicity	17.30	10.13	4	150311	15515	79578558
COVID-19	17.27	10.13	404	149911	157270	79436803
Atrioventricular block	17.25	10.13	62	150253	13979	79580094
Bulbar palsy	17.24	10.13	9	150306	265	79593808
Optic nerve operation	17.18	10.13	11	150304	479	79593594
Rales	17.15	10.13	79	150236	19922	79574151
Erection increased	17.08	10.13	10	150305	370	79593703
Grip strength decreased	17.06	10.13	10	150305	21859	79572214
Lung neoplasm malignant	17.05	10.13	100	150215	27692	79566381
Prostatic obstruction	16.95	10.13	6	150309	65	79594008
Respiratory tract haemorrhage	16.93	10.13	19	150296	1804	79592269
Haemorrhage urinary tract	16.88	10.13	22	150293	2439	79591634
Myoglobin blood increased	16.87	10.13	25	150290	3126	79590947
Flatulence	16.87	10.13	138	150177	42586	79551487
Blood 25-hydroxycholecalciferol decreased	16.86	10.13	10	150305	379	79593694
Choroidal detachment	16.84	10.13	12	150303	624	79593449
Mixed dementia	16.73	10.13	9	150306	282	79593791
Embolic stroke	16.70	10.13	42	150273	7784	79586289
Burning feet syndrome	16.67	10.13	8	150307	196	79593877
Dysgeusia	16.66	10.13	173	150142	57004	79537069
Candida infection	16.65	10.13	29	150286	38185	79555888
Femoral artery aneurysm	16.52	10.13	8	150307	200	79593873
Orthopnoea	16.45	10.13	49	150266	10024	79584049
Iris haemorrhage	16.41	10.13	4	150311	9	79594064
Urinary bladder haemorrhage	16.37	10.13	22	150293	2514	79591559
Bladder disorder	16.33	10.13	46	150269	9119	79584954
Bladder outlet obstruction	16.16	10.13	7	150308	134	79593939
Injection site erosion	16.12	10.13	7	150308	135	79593938
Ear infection	16.06	10.13	25	150290	34407	79559666
Scrotal pain	16.02	10.13	11	150304	539	79593534
Alanine aminotransferase increased	15.99	10.13	213	150102	162357	79431716
Renal colic	15.96	10.13	23	150292	2804	79591269
Faecaloma	15.89	10.13	53	150262	11511	79582562
Sperm concentration zero	15.83	10.13	3	150312	0	79594073
Iris injury	15.83	10.13	3	150312	0	79594073
Bursitis	15.80	10.13	27	150288	35817	79558256
Bone density decreased	15.78	10.13	3	150312	13344	79580729
Glycosylated haemoglobin increased	15.73	10.13	75	150240	19185	79574888
Actinic keratosis	15.69	10.13	35	150280	6007	79588066
International normalised ratio abnormal	15.64	10.13	34	150281	5734	79588339
Bone marrow failure	15.61	10.13	47	150268	51060	79543013
Sciatica	15.61	10.13	24	150291	33198	79560875
Sleep apnoea syndrome	15.59	10.13	120	150195	36358	79557715
Inadequate osteointegration	15.58	10.13	4	150311	12	79594061
Cardiac disorder	15.55	10.13	191	150124	65566	79528507
Tenosynovitis	15.48	10.13	5	150310	15549	79578524
Cerebral haematoma	15.28	10.13	41	150274	7901	79586172
Febrile bone marrow aplasia	15.24	10.13	3	150312	13017	79581056
Ear pain	15.20	10.13	24	150291	32845	79561228
Upper respiratory tract infection	15.14	10.13	105	150210	91063	79503010
Renal artery stenosis	15.00	10.13	25	150290	3457	79590616
Urinary tract disorder	14.97	10.13	26	150289	3716	79590357
Dysphagia	14.96	10.13	318	149997	121818	79472255
Tendon discomfort	14.95	10.13	10	150305	469	79593604
Melaena	14.90	10.13	178	150137	60712	79533361
Ligament pain	14.89	10.13	8	150307	250	79593823
Cornea verticillata	14.87	10.13	7	150308	164	79593909
Penis disorder	14.73	10.13	13	150302	923	79593150
Chronic kidney disease	14.73	10.13	190	150125	65964	79528109
Disorientation	14.70	10.13	182	150133	62594	79531479
Haematemesis	14.69	10.13	157	150158	52107	79541966
Oesophageal rupture	14.69	10.13	13	150302	926	79593147
Blood urine present	14.63	10.13	79	150236	21218	79572855
Multiple sclerosis relapse	14.62	10.13	143	150172	46390	79547683
Lupus-like syndrome	14.62	10.13	4	150311	13853	79580220
Aspergillus infection	14.61	10.13	9	150306	19152	79574921
Oropharyngeal pain	14.44	10.13	134	150181	109219	79484854
Product size issue	14.42	10.13	12	150303	786	79593287
Hyperglycaemia	14.41	10.13	199	150116	70136	79523937
International normalised ratio increased	14.36	10.13	232	150083	84489	79509584
Injection site warmth	14.32	10.13	5	150310	14802	79579271
Prostate infection	14.31	10.13	11	150304	643	79593430
Urethral obstruction	14.28	10.13	8	150307	272	79593801
Weight decreased	14.25	10.13	812	149503	354386	79239687
Left ventricular hypertrophy	14.25	10.13	50	150265	11141	79582932
Renal stone removal	14.24	10.13	7	150308	181	79593892
Aortic arteriosclerosis	14.20	10.13	43	150272	8875	79585198
Panniculitis	14.17	10.13	3	150312	12368	79581705
Suprapubic pain	14.08	10.13	13	150302	979	79593094
Forced expiratory flow decreased	14.04	10.13	8	150307	281	79593792
Prostate examination abnormal	14.03	10.13	7	150308	187	79593886
Adverse event	14.02	10.13	62	150253	60152	79533921
Injection site bruising	13.79	10.13	36	150279	40966	79553107
Knee arthroplasty	13.77	10.13	39	150276	43209	79550864
Executive dysfunction	13.74	10.13	8	150307	293	79593780
Pain in jaw	13.70	10.13	43	150272	46108	79547965
Circadian rhythm sleep disorder	13.62	10.13	11	150304	691	79593382
Nodule	13.52	10.13	14	150301	22980	79571093
Cardio-respiratory arrest	13.46	10.13	135	150180	108375	79485698
Therapeutic product effect incomplete	13.42	10.13	187	150128	141458	79452615
Polyuria	13.39	10.13	60	150255	14954	79579119
Aortic valve incompetence	13.38	10.13	44	150271	9486	79584587
Posterior reversible encephalopathy syndrome	13.32	10.13	18	150297	26263	79567810
Coronary artery disease	13.32	10.13	185	150130	65289	79528784
Acute respiratory failure	13.25	10.13	171	150144	59370	79534703
Leukopenia	13.22	10.13	148	150167	116365	79477708
Sudden death	13.17	10.13	80	150235	22431	79571642
Disability	13.12	10.13	8	150307	17112	79576961
Disseminated Bacillus Calmette-Guerin infection	13.11	10.13	7	150308	216	79593857
Hip fracture	13.04	10.13	101	150214	30660	79563413
Thoracic haemorrhage	13.02	10.13	7	150308	219	79593854
Joint effusion	13.01	10.13	9	150306	18005	79576068
Urinary tract infection staphylococcal	13.00	10.13	12	150303	903	79593170
Cytomegalovirus viraemia	12.97	10.13	4	150311	12817	79581256
Orthostatic intolerance	12.89	10.13	17	150298	1907	79592166
Burns second degree	12.87	10.13	20	150295	2608	79591465
Aplastic anaemia	12.86	10.13	9	150306	17896	79576177
Abnormal dreams	12.85	10.13	49	150266	11363	79582710
Aphthous ulcer	12.79	10.13	8	150307	16881	79577192
Restless legs syndrome	12.78	10.13	73	150242	20019	79574054
Dry eye	12.75	10.13	32	150283	36899	79557174
Atrial flutter	12.74	10.13	77	150238	21548	79572525
Bladder transitional cell carcinoma	12.74	10.13	20	150295	2630	79591443
Oral herpes	12.74	10.13	20	150295	27434	79566639
Breast cancer female	12.68	10.13	3	150312	11458	79582615
Anaphylactic reaction	12.68	10.13	99	150216	83644	79510429
Hyponatraemic syndrome	12.61	10.13	11	150304	769	79593304
Muscle haemorrhage	12.60	10.13	33	150282	6267	79587806
Mesenteric vascular insufficiency	12.58	10.13	6	150309	145	79593928
Rib fracture	12.54	10.13	93	150222	27854	79566219
Hallucination, visual	12.54	10.13	105	150210	32624	79561449
Renal cyst	12.49	10.13	58	150257	14674	79579399
Acne	12.44	10.13	20	150295	27170	79566903
Blood glucose increased	12.40	10.13	294	150021	114681	79479392
Dyspnoea at rest	12.38	10.13	36	150279	7266	79586807
Periorbital haematoma	12.36	10.13	12	150303	962	79593111
C-reactive protein increased	12.35	10.13	170	150145	128857	79465216
Intraventricular haemorrhage	12.34	10.13	28	150287	4859	79589214
Foot fracture	12.25	10.13	14	150301	21967	79572106
Tooth injury	12.19	10.13	17	150298	2011	79592062
Dysarthria	12.15	10.13	187	150128	67435	79526638
Overdose	12.03	10.13	260	150055	183946	79410127
Herpes simplex	11.98	10.13	4	150311	12183	79581890
Decreased vibratory sense	11.92	10.13	10	150305	663	79593410
Xanthelasma	11.87	10.13	6	150309	165	79593908
Wound haematoma	11.87	10.13	6	150309	165	79593908
Ventriculo-peritoneal shunt	11.86	10.13	4	150311	37	79594036
Wound haemorrhage	11.83	10.13	25	150290	4136	79589937
Respiratory disorder	11.82	10.13	44	150271	44812	79549261
Sleep disorder	11.74	10.13	104	150211	85573	79508500
Product impurity	11.73	10.13	5	150310	92	79593981
Mucosal haemorrhage	11.72	10.13	19	150296	2567	79591506
Prostatic haemorrhage	11.70	10.13	6	150309	170	79593903
Hepatomegaly	11.67	10.13	11	150304	18863	79575210
Hypoglycaemia	11.64	10.13	262	150053	101332	79492741
Neurogenic bladder	11.62	10.13	25	150290	4187	79589886
Respiratory tract inflammation	11.60	10.13	11	150304	857	79593216
Malpositioned teeth	11.59	10.13	4	150311	40	79594033
Fractured skull depressed	11.59	10.13	4	150311	40	79594033
Cellulitis gangrenous	11.55	10.13	7	150308	276	79593797
Graft versus host disease	11.54	10.13	7	150308	15019	79579054
Anal haemorrhage	11.53	10.13	25	150290	4209	79589864
Large intestine polyp	11.50	10.13	51	150264	12657	79581416
Infected dermal cyst	11.49	10.13	13	150302	1245	79592828
Hepatic cytolysis	11.48	10.13	21	150294	27130	79566943
Product colour issue	11.47	10.13	11	150304	869	79593204
Dacryostenosis acquired	11.46	10.13	9	150306	543	79593530
Breast disorder male	11.45	10.13	3	150312	10	79594063
Electrocardiogram abnormal	11.44	10.13	62	150253	16675	79577398
Peripheral venous disease	11.42	10.13	8	150307	15901	79578172
Medical device site haemorrhage	11.36	10.13	6	150309	181	79593892
Epididymitis	11.34	10.13	16	150299	1914	79592159
Hyperparathyroidism secondary	11.33	10.13	19	150296	2641	79591432
Movement disorder	11.28	10.13	89	150226	27170	79566903
Basosquamous carcinoma	11.25	10.13	5	150310	102	79593971
Bladder cyst	11.21	10.13	5	150310	103	79593970
Intervertebral disc space narrowing	11.12	10.13	15	150300	1720	79592353
Cardiogenic shock	11.12	10.13	41	150274	41873	79552200
Autoimmune disorder	11.09	10.13	9	150306	16603	79577470
Sedation complication	11.09	10.13	8	150307	15661	79578412
Peripheral artery stenosis	11.06	10.13	13	150302	1298	79592775
On and off phenomenon	11.04	10.13	21	150294	3219	79590854
Blood loss anaemia	10.99	10.13	58	150257	15440	79578633
Dyspnoea paroxysmal nocturnal	10.97	10.13	17	150298	2211	79591862
Adenocarcinoma gastric	10.94	10.13	15	150300	1746	79592327
Unemployment	10.93	10.13	4	150311	48	79594025
Rash	10.93	10.13	940	149375	577418	79016655
Hepatic failure	10.91	10.13	69	150246	61143	79532930
Bladder discomfort	10.91	10.13	10	150305	746	79593327
Rhabdomyolysis	10.91	10.13	263	150052	102868	79491205
Full blood count decreased	10.79	10.13	87	150228	26732	79567341
Urinary straining	10.79	10.13	4	150311	50	79594023
Prostatic adenoma	10.75	10.13	5	150310	114	79593959
Subdural haemorrhage	10.74	10.13	30	150285	5918	79588155
Gastrointestinal bacterial infection	10.71	10.13	11	150304	944	79593129
Flank pain	10.66	10.13	69	150246	19775	79574298
Mononuclear cell count abnormal	10.65	10.13	3	150312	14	79594059
Dysstasia	10.62	10.13	89	150226	27657	79566416
Hyperthyroidism	10.60	10.13	75	150240	22134	79571939
Acute myocardial infarction	10.57	10.13	204	150111	76832	79517241
Shock symptom	10.50	10.13	6	150309	212	79593861
Crying	10.49	10.13	17	150298	23026	79571047
Rhinitis allergic	10.47	10.13	5	150310	12264	79581809
Febrile neutropenia	10.38	10.13	344	149971	230655	79363418
Memory impairment	10.36	10.13	280	150035	111454	79482619
Joint dislocation	10.32	10.13	10	150305	16929	79577144
Atheroembolism	10.30	10.13	7	150308	337	79593736
Brain oedema	10.27	10.13	20	150295	25243	79568830
Anal incontinence	10.27	10.13	64	150251	18104	79575969
Bladder dysfunction	10.19	10.13	12	150303	1200	79592873
Penile pain	10.19	10.13	11	150304	1000	79593073
Uveitis	10.18	10.13	10	150305	16820	79577253
Coagulation factor VII level decreased	10.15	10.13	6	150309	226	79593847

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G04CA02	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists
ATC	G04CA52	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists
ATC	G04CA53	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists
ATC	G04CA54	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists
FDA MoA	N0000000099	Adrenergic alpha-Antagonists
FDA EPC	N0000175553	alpha-Adrenergic Blocker
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D058668	Adrenergic alpha-1 Receptor Antagonists
MeSH PA	D000317	Adrenergic alpha-Antagonists
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D064804	Urological Agents
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:37890	alpha-adrenergic receptor blockaders

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Benign prostatic hyperplasia	indication	266569009
Priapism	contraindication	6273006	DOID:9286
Orthostatic hypotension	contraindication	28651003
Oligozoospermia	contraindication	88311004
Cataract surgery	contraindication	110473004
Disease of liver	contraindication	235856003	DOID:409
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
Dizziness	contraindication	404640003
Breastfeeding (mother)	contraindication	413712001
Intraoperative floppy iris syndrome	contraindication	418801006
High-Grade Prostate Cancer	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.71	acidic
pKa2	8.16	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.89		CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	7.87		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	9.10		CHEMBL
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	7.08		CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	10.54		CHEMBL
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	9.55		CHEMBL
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	8.10		CHEMBL
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	10.24		CHEMBL
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	9.21		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		Ki	10.52		CHEMBL
Alpha-2B adrenergic receptor	GPCR		ADA2B_RAT		Ki	8.17		CHEMBL
Alpha-1D adrenergic receptor	GPCR		ADA1D_RAT		Ki	10.15		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		Ki	9.90		CHEMBL
Alpha-1B adrenergic receptor	GPCR		ADA1B_MESAU		Ki	9.70		CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		Ki	6.03		CHEMBL

External reference:

ID	Source
4024076	VUID
N0000022081	NUI
D01024	KEGG_DRUG
106463-17-6	SECONDARY_CAS_RN
4021051	VANDF
4024076	VANDF
C0257343	UMLSCUI
CHEBI:9398	CHEBI
JGX	PDB_CHEM_ID
CHEMBL836	ChEMBL_ID
CHEMBL1200914	ChEMBL_ID
D000077409	MESH_DESCRIPTOR_UI
DB00706	DRUGBANK_ID
129211	PUBCHEM_CID
488	IUPHAR_LIGAND_ID
6750	INN_ID
G3P28OML5I	UNII
236495	RXNORM
171693	MMSL
20642	MMSL
5541	MMSL
d04121	MMSL
006115	NDDF
006116	NDDF
108559004	SNOMEDCT_US
108560009	SNOMEDCT_US
372509005	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
FLOMAX	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5837	CAPSULE	0.40 mg	ORAL	NDA	30 sections
FLOMAX	HUMAN PRESCRIPTION DRUG LABEL	1	0024-5837	CAPSULE	0.40 mg	ORAL	NDA	30 sections
JALYN	HUMAN PRESCRIPTION DRUG LABEL	2	0173-0809	CAPSULE	0.40 mg	ORAL	NDA	29 sections
JALYN	HUMAN PRESCRIPTION DRUG LABEL	2	0173-0809	CAPSULE	0.40 mg	ORAL	NDA	29 sections
Tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2996	CAPSULE	0.40 mg	ORAL	ANDA	19 sections
Tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2996	CAPSULE	0.40 mg	ORAL	ANDA	19 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7995	CAPSULE	0.40 mg	ORAL	ANDA	26 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8055	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8055	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0781-2076	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6401	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Dutasteride and Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	10370-280	CAPSULE	0.40 mg	ORAL	ANDA	28 sections
Dutasteride and Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	2	10370-280	CAPSULE	0.40 mg	ORAL	ANDA	28 sections
Tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-280	CAPSULE	0.40 mg	ORAL	ANDA	18 sections
TAMSULOSIN HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	10544-550	CAPSULE	0.40 mg	ORAL	ANDA	17 sections
TAMSULOSIN HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-298	CAPSULE	0.40 mg	ORAL	ANDA	17 sections
FLOMAX	HUMAN PRESCRIPTION DRUG LABEL	1	16590-489	CAPSULE	0.40 mg	ORAL	NDA	28 sections
Tamsulosin Hydrochloride	Human Prescription Drug Label	1	16714-713	CAPSULE	0.40 mg	ORAL	ANDA	26 sections
TAMSULOSIN HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	33261-839	CAPSULE	0.40 mg	ORAL	ANDA	17 sections
Tamsulosin Hydrochloride	Human Prescription Drug Label	1	33342-159	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	Human Prescription Drug Label	1	33342-159	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
TAMSULOSIN HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	42254-012	CAPSULE	0.40 mg	ORAL	ANDA	17 sections
Tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-264	CAPSULE	0.40 mg	ORAL	ANDA	19 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-725	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-725	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-947	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-947	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-947	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
tamsulosin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43353-013	CAPSULE	0.40 mg	ORAL	ANDA	27 sections
Tamsulosin Hydrochloride	Human Prescription Drug Label	1	43353-019	CAPSULE	0.40 mg	ORAL	ANDA	26 sections