tamsulosin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihypertensive substances, prazosin derivatives 2562 106133-20-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tamsulosin
  • tamsulosin hydrochloride
  • tamsulosin HCl
  • LY-253352
A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA.
  • Molecular weight: 408.51
  • Formula: C20H28N2O5S
  • CLOGP: 2.17
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.88
  • ALOGS: -4.79
  • ROTB: 11
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8.70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.03 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.62 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 49
kinase-selectivity-class AXL,BRAF,GRK2,PDK4,SIK2,TEK 6
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 12.246 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.013 % High 1

Approvals:

DateAgencyCompanyOrphan
April 15, 1997 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nephrolithiasis 237.96 14.58 114 10014 48971 90569348
Urinary tract infection 125.15 14.58 162 9966 305470 90312849
Distributive shock 114.52 14.58 33 10095 3391 90614928
Urinary retention 75.49 14.58 49 10079 37695 90580624
Multiple sclerosis relapse 67.60 14.58 52 10076 52253 90566066
Renal colic 46.79 14.58 14 10114 1639 90616680
COVID-19 43.43 14.58 72 10056 168771 90449548
Ligament pain 38.06 14.58 8 10120 219 90618100
Residual urine volume increased 37.62 14.58 7 10121 100 90618219
Fall 35.23 14.58 126 10002 481684 90136635
Hypotension 34.72 14.58 97 10031 325300 90293019
Catarrh 34.27 14.58 11 10117 1623 90616696
Intentional overdose 34.06 14.58 47 10081 93787 90524532
Burns second degree 32.20 14.58 11 10117 1969 90616350
Steroid dependence 30.73 14.58 11 10117 2258 90616061
Multiple sclerosis 30.23 14.58 25 10103 27815 90590504
Respiratory tract inflammation 30.06 14.58 8 10120 612 90617707
Decreased vibratory sense 29.06 14.58 7 10121 358 90617961
Renal stone removal 28.91 14.58 6 10122 154 90618165
Completed suicide 27.26 14.58 54 10074 145004 90473315
Depressed level of consciousness 27.23 14.58 37 10091 72747 90545572
Pertussis 27.05 14.58 8 10120 899 90617420
Joint swelling 25.81 14.58 12 10116 503288 90115031
Syncope 25.67 14.58 50 10078 132613 90485706
Drug dispensed to wrong patient 24.09 14.58 6 10122 353 90617966
Vertigo 23.89 14.58 34 10094 69777 90548542
Hypopnoea 23.61 14.58 11 10117 4420 90613899
Micturition urgency 23.48 14.58 15 10113 11218 90607101
Urinary tract obstruction 23.46 14.58 9 10119 2240 90616079
Rheumatoid arthritis 23.12 14.58 6 10122 362608 90255711
Central nervous system stimulation 21.38 14.58 4 10124 59 90618260
Disorganised speech 21.31 14.58 8 10120 1877 90616442
Progressive multifocal leukoencephalopathy 21.17 14.58 16 10112 15639 90602680
Product use in unapproved indication 20.46 14.58 83 10045 336153 90282166
Gingival pain 20.45 14.58 13 10115 9639 90608680
Arthropathy 19.92 14.58 8 10120 366234 90252085
Hydronephrosis 19.77 14.58 14 10114 12388 90605931
Drug ineffective 19.65 14.58 84 10044 1384214 89234105
Off label use 19.44 14.58 198 9930 1102054 89516265
Treatment failure 19.43 14.58 5 10123 303923 90314396
Chorioretinitis 19.09 14.58 6 10122 827 90617492
Immune reconstitution inflammatory syndrome 18.84 14.58 11 10117 7008 90611311
Sinus pain 18.70 14.58 10 10118 5379 90612940
Urinary incontinence 18.66 14.58 22 10106 37544 90580775
Flank pain 18.29 14.58 16 10112 19206 90599113
Wrong product administered 17.94 14.58 11 10117 7654 90610665
Cystitis 17.87 14.58 29 10099 66689 90551630
Maternal exposure during pregnancy 17.81 14.58 9 10119 360054 90258265
Kidney infection 17.79 14.58 18 10110 25898 90592421
Impaired quality of life 17.61 14.58 17 10111 23127 90595192
Wound 17.52 14.58 6 10122 302974 90315345
Stress 17.37 14.58 32 10096 81363 90536956
Drug intolerance 17.02 14.58 15 10113 447576 90170743
Blister 16.67 14.58 4 10124 254994 90363325
Hypersensitivity 16.38 14.58 16 10112 454661 90163658
Erythropenia 16.23 14.58 4 10124 225 90618094
Heparin-induced thrombocytopenia 16.07 14.58 9 10119 5303 90613016
Hypertensive nephropathy 16.03 14.58 5 10123 673 90617646
Tendon pain 16.02 14.58 8 10120 3740 90614579
Contraindicated product administered 15.83 14.58 8 10120 320131 90298188
Somnolence 15.50 14.58 55 10073 209029 90409290
Duodenal ulcer perforation 15.43 14.58 3 10125 221285 90397034
Product dose omission issue 15.41 14.58 69 10059 291618 90326701
Orthostatic hypotension 15.24 14.58 21 10107 41806 90576513
Alopecia 15.04 14.58 20 10108 495051 90123268
Hypoxia 14.87 14.58 28 10100 72371 90545948
Impaired healing 14.68 14.58 4 10124 234195 90384124

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fall 422.81 10.90 2168 194645 232352 42192170
Dizziness 404.20 10.90 2238 194575 247016 42177506
Urinary retention 342.86 10.90 662 196151 41552 42382970
Orthostatic hypotension 286.60 10.90 510 196303 30060 42394462
Drug ineffective 273.04 10.90 1751 195062 628446 41796076
Urinary tract infection 244.59 10.90 1007 195806 98277 42326245
Syncope 232.97 10.90 993 195820 98413 42326109
Drug abuse 226.53 10.90 100 196713 104671 42319851
Toxicity to various agents 223.44 10.90 451 196362 228685 42195837
Dysuria 186.53 10.90 431 196382 30665 42393857
Benign prostatic hyperplasia 183.06 10.90 340 196473 20712 42403810
Multiple organ dysfunction syndrome 168.94 10.90 121 196692 96914 42327608
Product prescribing error 167.83 10.90 372 196441 25740 42398782
Obstructive airways disorder 157.19 10.90 351 196462 24408 42400114
Atrial fibrillation 145.59 10.90 1123 195690 138470 42286052
Nocturia 144.20 10.90 225 196588 11887 42412635
Off label use 143.36 10.90 2083 194730 636252 41788270
Pollakiuria 138.35 10.90 315 196498 22190 42402332
Idiopathic pulmonary fibrosis 137.69 10.90 136 196677 4468 42420054
Micturition urgency 121.25 10.90 206 196607 11692 42412830
Myelosuppression 120.01 10.90 21 196792 40440 42384082
Wheezing 115.91 10.90 531 196282 54250 42370272
Full blood count abnormal 115.79 10.90 352 196461 29524 42394998
Drug resistance 115.26 10.90 12 196801 34236 42390286
Haematuria 112.61 10.90 547 196266 57252 42367270
Dyspnoea 107.35 10.90 2737 194076 439884 41984638
Treatment failure 106.49 10.90 80 196733 62544 42361978
Presyncope 102.45 10.90 280 196533 22107 42402415
Fatigue 100.71 10.90 2677 194136 432964 41991558
Urinary incontinence 100.15 10.90 272 196541 21396 42403126
Retrograde ejaculation 96.88 10.90 48 196765 487 42424035
Dyspnoea exertional 96.54 10.90 473 196340 49675 42374847
Product monitoring error 92.31 10.90 108 196705 4315 42420207
Febrile neutropenia 91.97 10.90 493 196320 185210 42239312
Bronchiectasis 90.19 10.90 233 196580 17786 42406736
Hypotension 89.74 10.90 1679 195134 255952 42168570
Loss of personal independence in daily activities 89.64 10.90 461 196352 49355 42375167
Pulmonary vasculitis 86.87 10.90 125 196688 6141 42418381
Confusional state 86.63 10.90 1167 195646 166430 42258092
Drug dependence 82.24 10.90 17 196796 29077 42395445
Floppy iris syndrome 80.00 10.90 36 196777 288 42424234
Right atrial hypertrophy 77.19 10.90 46 196767 691 42423831
Thrombocytopenia 76.55 10.90 539 196274 189740 42234782
Asthma 75 10.90 519 196294 61795 42362727
Fractional exhaled nitric oxide increased 74.86 10.90 61 196752 1548 42422974
Hypertonic bladder 72.44 10.90 71 196742 2310 42422212
Myoglobin blood increased 72.05 10.90 87 196726 3595 42420927
Bradycardia 71.61 10.90 655 196158 84829 42339693
Asthenia 71.59 10.90 1749 195064 279044 42145478
Prostatomegaly 71.10 10.90 113 196700 6064 42418458
Balance disorder 70.39 10.90 418 196395 47227 42377295
Malignant melanoma in situ 68.76 10.90 74 196739 2693 42421829
Vomiting 68.28 10.90 935 195878 288788 42135734
Ventricular fibrillation 67.87 10.90 27 196786 30096 42394426
Urogenital haemorrhage 67.11 10.90 42 196771 692 42423830
Neuritis 66.45 10.90 110 196703 6110 42418412
Cytomegalovirus infection 66.43 10.90 33 196780 32273 42392249
Peripheral swelling 66.40 10.90 673 196140 89597 42334925
Completed suicide 64.20 10.90 229 196584 96236 42328286
Total lung capacity abnormal 62.13 10.90 89 196724 4354 42420168
Labelled drug-drug interaction medication error 61.69 10.90 185 196628 15397 42409125
Hallucination 61.16 10.90 465 196348 57042 42367480
Needle fatigue 60.72 10.90 48 196765 1165 42423357
Pyrexia 60.44 10.90 1373 195440 392669 42031853
Alanine aminotransferase increased 60.08 10.90 208 196605 88198 42336324
Disease progression 59.19 10.90 404 196409 143252 42281270
Cardiogenic shock 58.71 10.90 47 196766 35593 42388929
Urine flow decreased 56.93 10.90 49 196764 1344 42423178
General physical health deterioration 56.87 10.90 998 195815 150248 42274274
Right ventricular hypertrophy 56.25 10.90 51 196762 1501 42423021
Drug intolerance 56.16 10.90 187 196626 80237 42344285
Mucosal inflammation 55.32 10.90 89 196724 49285 42375237
Ascites 54.72 10.90 112 196701 56566 42367956
Erectile dysfunction 54.54 10.90 244 196569 24669 42399853
Gait spastic 54.44 10.90 48 196765 1361 42423161
Hot flush 54.38 10.90 226 196587 22125 42402397
Plantar fasciitis 54.38 10.90 69 196744 3001 42421521
Cardiac arrest 54.18 10.90 290 196523 109030 42315492
Sensation of foreign body 52.93 10.90 74 196739 3539 42420983
Drug ineffective for unapproved indication 52.87 10.90 82 196731 46081 42378441
Bronchial secretion retention 52.81 10.90 50 196763 1557 42422965
Therapy partial responder 52.04 10.90 14 196799 20007 42404515
Relapsing-remitting multiple sclerosis 51.99 10.90 48 196765 1447 42423075
Suicide attempt 51.74 10.90 83 196730 46017 42378505
Congenital hiatus hernia 51.53 10.90 98 196715 6076 42418446
Prostatic specific antigen increased 50.88 10.90 183 196630 16742 42407780
Aortic valve stenosis 50.34 10.90 66 196747 2966 42421556
Therapy non-responder 50.20 10.90 107 196706 53252 42371270
Pulmonary function test abnormal 50.03 10.90 62 196751 2632 42421890
Bronchial wall thickening 49.90 10.90 45 196768 1315 42423207
Prostatitis 49.48 10.90 97 196716 6151 42418371
Coma 49.05 10.90 109 196704 53445 42371077
Leukopenia 48.69 10.90 179 196634 74567 42349955
Bone marrow failure 48.11 10.90 49 196764 33044 42391478
Neurological symptom 47.75 10.90 127 196686 9864 42414658
Vertigo 46.72 10.90 295 196518 34052 42390470
Abdominal pain lower 46.40 10.90 142 196671 11950 42412572
Prostatic disorder 45.97 10.90 70 196743 3619 42420903
Seizure 45.79 10.90 347 196466 120214 42304308
Haematochezia 45.54 10.90 441 196372 57995 42366527
Hospice care 44.59 10.90 112 196701 8401 42416121
Gastrooesophageal reflux disease 43.98 10.90 357 196456 44666 42379856
Urosepsis 43.96 10.90 161 196652 14859 42409663
Blood bilirubin increased 43.82 10.90 80 196733 42172 42382350
Constipation 43.72 10.90 1019 195794 161272 42263250
Dementia 43.57 10.90 171 196642 16309 42408213
Dust allergy 42.49 10.90 83 196730 5249 42419273
Haemophagocytic lymphohistiocytosis 41.60 10.90 16 196797 18206 42406316
Sleep disorder due to a general medical condition 41.31 10.90 175 196638 17278 42407244
Aspergillus infection 41.30 10.90 11 196802 15826 42408696
Respiratory symptom 41.29 10.90 129 196684 10977 42413545
Appendicitis 40.97 10.90 22 196791 20591 42403931
Spirometry abnormal 40.88 10.90 80 196733 5066 42419456
Blood phosphorus increased 40.60 10.90 5 196808 12520 42412002
Cardio-respiratory arrest 40.48 10.90 137 196676 58499 42366023
Eosinophilic granulomatosis with polyangiitis 40.48 10.90 109 196704 8529 42415993
Systemic infection 40.24 10.90 80 196733 5125 42419397
Acquired haemophilia 40.23 10.90 44 196769 1631 42422891
Neutropenia 40.23 10.90 663 196150 198768 42225754
Hypoacusis 40.06 10.90 182 196631 18520 42406002
Chronic obstructive pulmonary disease 39.64 10.90 456 196357 62658 42361864
Pancytopenia 39.63 10.90 350 196463 117393 42307129
Intentional overdose 39.19 10.90 115 196698 51341 42373181
Aspartate aminotransferase increased 39.17 10.90 203 196610 76960 42347562
Bladder disorder 38.95 10.90 65 196748 3634 42420888
Productive cough 38.64 10.90 386 196427 51181 42373341
Memory impairment 38.63 10.90 378 196435 49844 42374678
Brain natriuretic peptide increased 38.58 10.90 92 196721 6678 42417844
Conjunctivitis allergic 37.73 10.90 84 196729 5827 42418695
Forced expiratory volume decreased 37.50 10.90 98 196715 7532 42416990
Breath sounds abnormal 37.41 10.90 132 196681 11961 42412561
Hepatic failure 37.01 10.90 75 196738 38025 42386497
Disseminated intravascular coagulation 36.86 10.90 36 196777 24758 42399764
Pancreatitis 36.48 10.90 92 196721 43176 42381346
Mite allergy 35.98 10.90 75 196738 4971 42419551
Drug hypersensitivity 35.90 10.90 290 196523 99099 42325423
Gait disturbance 35.85 10.90 644 196169 97356 42327166
IVth nerve paralysis 35.34 10.90 26 196787 565 42423957
Pain in extremity 35.29 10.90 928 195885 149676 42274846
Cytokine release syndrome 35.02 10.90 98 196715 44429 42380093
Sedation 35.02 10.90 54 196759 30421 42394101
Synovitis 34.99 10.90 14 196799 15553 42408969
Respiratory arrest 34.99 10.90 48 196765 28376 42396146
Cytomegalovirus infection reactivation 34.95 10.90 5 196808 11173 42413349
Genital swelling 34.40 10.90 19 196794 245 42424277
Orbital myositis 34.23 10.90 16 196797 141 42424381
Dizziness postural 34.18 10.90 96 196717 7699 42416823
Overdose 34.07 10.90 316 196497 104948 42319574
Drug use disorder 33.80 10.90 4 196809 10329 42414193
Antineutrophil cytoplasmic antibody positive 33.64 10.90 67 196746 4298 42420224
Pulmonary alveolar haemorrhage 33.10 10.90 146 196667 14670 42409852
Myocardial infarction 32.92 10.90 390 196423 123619 42300903
Mycotic allergy 32.91 10.90 71 196742 4820 42419702
Priapism 32.21 10.90 83 196730 6324 42418198
Thrombotic microangiopathy 32.09 10.90 14 196799 14768 42409754
Obstruction 31.98 10.90 54 196759 3049 42421473
Contusion 31.80 10.90 315 196498 41670 42382852
Haematoma 31.71 10.90 230 196583 27793 42396729
Bronchopulmonary aspergillosis 31.53 10.90 26 196787 19403 42405119
Pneumocystis jirovecii pneumonia 31.52 10.90 42 196771 25139 42399383
Bacterial infection 31.47 10.90 50 196763 27829 42396693
Cystitis 31.42 10.90 122 196691 11576 42412946
Product substitution issue 31.36 10.90 119 196694 11171 42413351
Rapid eye movement sleep behaviour disorder 31.28 10.90 19 196794 296 42424226
Lower urinary tract symptoms 30.87 10.90 21 196792 401 42424121
Infusion related reaction 30.84 10.90 160 196653 60646 42363876
Febrile bone marrow aplasia 30.81 10.90 5 196808 10176 42414346
Muscle spasms 30.61 10.90 563 196250 85481 42339041
Plasma cell myeloma 30.43 10.90 345 196468 47233 42377289
Muscular weakness 30.29 10.90 548 196265 82950 42341572
Brain oedema 30.21 10.90 19 196794 16308 42408214
Graft versus host disease 30.09 10.90 11 196802 12914 42411608
Loss of consciousness 30.03 10.90 596 196217 91758 42332764
Bladder spasm 29.94 10.90 32 196781 1155 42423367
Adverse drug reaction 29.90 10.90 284 196529 37150 42387372
Muscle spasticity 29.89 10.90 84 196729 6738 42417784
BK virus infection 29.75 10.90 3 196810 8781 42415741
Rectal prolapse 29.56 10.90 23 196790 545 42423977
Renal failure 29.56 10.90 476 196337 143250 42281272
Hormone receptor positive breast cancer 29.39 10.90 10 196803 33 42424489
Palpitations 29.25 10.90 361 196452 50436 42374086
Dysgeusia 29.13 10.90 263 196550 33926 42390596
Perineal pain 28.88 10.90 29 196784 972 42423550
Tongue dry 28.74 10.90 18 196795 297 42424225
Monoparesis 28.52 10.90 50 196763 2910 42421612
Hepatic vein dilatation 28.40 10.90 16 196797 215 42424307
Akathisia 27.75 10.90 7 196806 10444 42414078
Plasmapheresis 27.57 10.90 20 196793 425 42424097
Subdural haematoma 27.40 10.90 192 196621 22946 42401576
Device dislocation 27.33 10.90 89 196724 7742 42416780
Ejaculation failure 27.32 10.90 26 196787 815 42423707
Full blood count decreased 26.98 10.90 175 196638 20385 42404137
Micturition disorder 26.68 10.90 44 196769 2436 42422086
Post transplant lymphoproliferative disorder 26.46 10.90 5 196808 9115 42415407
Aplastic anaemia 26.45 10.90 12 196801 12372 42412150
Status epilepticus 26.34 10.90 20 196793 15558 42408964
Hepatitis 26.30 10.90 54 196759 27246 42397276
Acute respiratory distress syndrome 26.18 10.90 63 196750 30045 42394477
Haematotoxicity 26.17 10.90 9 196804 10976 42413546
Transaminases increased 26.14 10.90 72 196741 32813 42391709
Incorrect route of product administration 26.12 10.90 45 196768 24260 42400262
Poisoning 25.99 10.90 18 196795 14681 42409841
Prostatic operation 25.67 10.90 20 196793 475 42424047
Renal cyst haemorrhage 25.65 10.90 23 196790 667 42423855
Diabetes mellitus 25.20 10.90 168 196645 59919 42364603
Intentional product misuse 25.01 10.90 175 196638 61725 42362797
Bladder discomfort 24.87 10.90 13 196800 149 42424373
Abdominal wall haemorrhage 24.87 10.90 20 196793 498 42424024
Bladder catheterisation 24.86 10.90 24 196789 766 42423756
Cataract operation 24.81 10.90 32 196781 1415 42423107
Respiratory distress 24.77 10.90 104 196709 41716 42382806
Rectal haemorrhage 24.58 10.90 343 196470 49263 42375259
Hip fracture 24.45 10.90 125 196688 13347 42411175
Product use in unapproved indication 24.29 10.90 657 196156 183799 42240723
Radiation inflammation 24.26 10.90 27 196786 1021 42423501
Sleep apnoea syndrome 24.25 10.90 177 196636 21431 42403091
Acute graft versus host disease in skin 23.98 10.90 3 196810 7421 42417101
Prostatic mass 23.86 10.90 9 196804 43 42424479
Cataract 23.85 10.90 231 196582 30373 42394149
Dacryocystitis 23.69 10.90 9 196804 44 42424478
Cystitis haemorrhagic 23.58 10.90 3 196810 7326 42417196
Cardiac amyloidosis 23.52 10.90 37 196776 1968 42422554
Swollen tongue 23.31 10.90 173 196640 21058 42403464
Malignant spinal cord compression 23.30 10.90 12 196801 133 42424389
Inappropriate antidiuretic hormone secretion 23.07 10.90 143 196670 16398 42408124
Post micturition dribble 23.05 10.90 7 196806 14 42424508
Factitious disorder 23.05 10.90 9 196804 48 42424474
Drug reaction with eosinophilia and systemic symptoms 22.89 10.90 108 196705 41967 42382555
Hepatomegaly 22.81 10.90 13 196800 11772 42412750
Dysphonia 22.79 10.90 216 196597 28234 42396288
Head injury 22.76 10.90 168 196645 20414 42404108
Klebsiella infection 22.66 10.90 12 196801 11320 42413202
Stress 22.60 10.90 116 196697 44096 42380426
Herpes simplex 22.59 10.90 3 196810 7092 42417430
Ejaculation disorder 22.56 10.90 26 196787 1022 42423500
Platypnoea 22.33 10.90 8 196805 32 42424490
Liver palpable 22.21 10.90 15 196798 283 42424239
Arteriovenous fistula 22.18 10.90 27 196786 1125 42423397
Respiratory depression 22.10 10.90 33 196780 18835 42405687
Coagulopathy 22.06 10.90 43 196770 22119 42402403
Venoocclusive liver disease 21.98 10.90 10 196803 10292 42414230
Acute hepatic failure 21.86 10.90 28 196785 17045 42407477
Death 21.79 10.90 2489 194324 468696 41955826
Intervertebral disc degeneration 21.58 10.90 79 196734 7288 42417234
Agranulocytosis 21.48 10.90 71 196742 30541 42393981
Candida infection 21.45 10.90 42 196771 21568 42402954
Wound 21.43 10.90 144 196669 16973 42407549
Anaphylactic reaction 21.37 10.90 113 196700 42630 42381892
Nephropathy toxic 21.16 10.90 28 196785 16810 42407712
Urinary tract obstruction 21.08 10.90 53 196760 3978 42420544
Oesophageal ulcer haemorrhage 21.01 10.90 16 196797 367 42424155
Nephrolithiasis 20.88 10.90 261 196552 36569 42387953
Cytomegalovirus viraemia 20.73 10.90 11 196802 10366 42414156
Testicular swelling 20.62 10.90 35 196778 1984 42422538
Diastolic dysfunction 20.56 10.90 75 196738 6908 42417614
Haematospermia 20.43 10.90 15 196798 325 42424197
Pathogen resistance 20.27 10.90 14 196799 11436 42413086
Vena cava injury 20.27 10.90 15 196798 329 42424193
SARS-CoV-2 antibody test positive 20.25 10.90 16 196797 388 42424134
Nightmare 20.09 10.90 190 196623 24822 42399700
Neutrophil count decreased 19.81 10.90 192 196621 63223 42361299
Posterior reversible encephalopathy syndrome 19.78 10.90 18 196795 12803 42411719
Parosmia 19.68 10.90 79 196734 7612 42416910
Prostatic varices 19.58 10.90 5 196808 3 42424519
Therapeutic response decreased 19.55 10.90 96 196717 36916 42387606
Prostatism 19.52 10.90 14 196799 292 42424230
Milk-alkali syndrome 19.52 10.90 20 196793 687 42423835
Taste disorder 19.43 10.90 96 196717 10111 42414411
Platelet distribution width increased 19.38 10.90 11 196802 150 42424372
Oedema peripheral 19.27 10.90 790 196023 135286 42289236
Vascular anastomotic haemorrhage 19.24 10.90 14 196799 299 42424223
Secretion discharge 19.20 10.90 78 196735 7557 42416965
Hyperphosphataemia 19.19 10.90 19 196794 12985 42411537
Stomatitis 19.02 10.90 145 196668 50184 42374338
Hepatic function abnormal 18.82 10.90 150 196663 51417 42373105
Tachyarrhythmia 18.81 10.90 50 196763 3882 42420640
Pulmonary haemorrhage 18.80 10.90 15 196798 11382 42413140
Joint injury 18.70 10.90 124 196689 14552 42409970
Transient ischaemic attack 18.66 10.90 238 196575 33501 42391021
Intentional product use issue 18.63 10.90 227 196586 71606 42352916
Genital pain 18.62 10.90 22 196791 888 42423634
Hepatotoxicity 18.62 10.90 57 196756 25110 42399412
Immune reconstitution inflammatory syndrome 18.50 10.90 12 196801 10131 42414391
Diarrhoea 18.49 10.90 2413 194400 458436 41966086
Serum ferritin abnormal 18.47 10.90 13 196800 263 42424259
Vascular compression 18.46 10.90 15 196798 379 42424143
Burns second degree 18.39 10.90 66 196747 6030 42418492
Intentional self-injury 18.38 10.90 26 196787 15176 42409346
Septic shock 18.37 10.90 305 196508 91367 42333155
Prostate cancer 18.35 10.90 299 196514 44344 42380178
Osteonecrosis 18.34 10.90 28 196785 15837 42408685
Testicular infarction 18.33 10.90 8 196805 59 42424463
Bladder neck obstruction 18.31 10.90 10 196803 126 42424396
Capillaritis 18.14 10.90 35 196778 2193 42422329
Lymphopenia 18.06 10.90 46 196767 21517 42403005
Vitreous loss 18.00 10.90 5 196808 6 42424516
Atrioventricular block 18.00 10.90 90 196723 9525 42414997
Normochromic normocytic anaemia 17.95 10.90 86 196727 8945 42415577
Bladder pain 17.91 10.90 18 196795 604 42423918
Product use issue 17.90 10.90 248 196565 76503 42348019
Exostosis 17.88 10.90 62 196751 5569 42418953
Hyperammonaemia 17.80 10.90 7 196806 7859 42416663
Insomnia 17.78 10.90 691 196122 117562 42306960
Transplant rejection 17.69 10.90 22 196791 13566 42410956
Suprapubic pain 17.67 10.90 16 196797 470 42424052
Kidney transplant rejection 17.65 10.90 9 196804 8674 42415848
Lacunar stroke 17.57 10.90 13 196800 285 42424237
Pruritus 17.56 10.90 1052 195761 187719 42236803
Liver disorder 17.56 10.90 109 196704 39535 42384987
Pseudomonas infection 17.55 10.90 29 196784 15894 42408628
Chest X-ray abnormal 17.35 10.90 53 196760 4455 42420067
Aggression 17.28 10.90 126 196687 44037 42380485
Hemiparaesthesia 17.23 10.90 11 196802 188 42424334
Iris haemorrhage 17.17 10.90 5 196808 8 42424514
Cornea verticillata 17.15 10.90 9 196804 104 42424418
Palliative care 17.13 10.90 24 196789 1150 42423372
Hyponatraemic syndrome 17.13 10.90 11 196802 190 42424332
Hypopnoea 17.10 10.90 77 196736 7805 42416717
Extrapyramidal disorder 17.08 10.90 31 196782 16381 42408141
Urinary hesitation 17.03 10.90 41 196772 2994 42421528
Blood creatine phosphokinase increased 17.00 10.90 142 196671 48196 42376326
Pulmonary pain 16.98 10.90 28 196785 1550 42422972
Cyanosis 16.92 10.90 27 196786 15004 42409518
Mean cell volume increased 16.89 10.90 48 196765 3875 42420647
Flatulence 16.82 10.90 184 196629 24968 42399554
Intestinal haemorrhage 16.68 10.90 48 196765 3903 42420619
Pemphigoid 16.54 10.90 100 196713 11367 42413155
Narrow anterior chamber angle 16.50 10.90 9 196804 113 42424409
Pneumonia fungal 16.44 10.90 11 196802 9135 42415387
Psoriatic arthropathy 16.11 10.90 60 196753 24907 42399615
Poisoning deliberate 15.90 10.90 14 196799 10120 42414402
Psychotic disorder 15.87 10.90 75 196738 29133 42395389
Carotid arteriosclerosis 15.86 10.90 34 196779 2298 42422224
Metastatic lymphoma 15.82 10.90 14 196799 399 42424123
Guillain-Barre syndrome 15.79 10.90 71 196742 7192 42417330
Prostate tenderness 15.77 10.90 7 196806 54 42424468
Cough 15.72 10.90 988 195825 177115 42247407
Puncture site haematoma 15.66 10.90 10 196803 171 42424351
Cardiac disorder 15.63 10.90 315 196498 48617 42375905
Blood uric acid increased 15.62 10.90 30 196783 15517 42409005
Intraductal papillary mucinous neoplasm 15.61 10.90 15 196798 476 42424046
Benign gastrointestinal neoplasm 15.59 10.90 9 196804 127 42424395
Myocardial ischaemia 15.57 10.90 37 196776 17725 42406797
Anhedonia 15.41 10.90 8 196805 7632 42416890
Injection site erosion 15.41 10.90 9 196804 130 42424392
Renal haematoma 15.40 10.90 17 196796 637 42423885
Idiopathic interstitial pneumonia 15.08 10.90 14 196799 425 42424097
Perineal cyst 15.07 10.90 11 196802 236 42424286
Faeces discoloured 15.06 10.90 132 196681 16882 42407640
Diverticulum intestinal haemorrhagic 15.06 10.90 39 196774 2980 42421542
Granulocytopenia 15.03 10.90 7 196806 7107 42417415
Drug level increased 15.00 10.90 66 196747 26134 42398388
Spinal stenosis 14.98 10.90 64 196749 6342 42418180
Vasculitis 14.91 10.90 140 196673 18254 42406268
Tendon discomfort 14.79 10.90 13 196800 367 42424155
Hyperthyroidism 14.70 10.90 115 196698 14226 42410296
Hallucination, auditory 14.66 10.90 29 196784 14835 42409687
Streptococcal infection 14.65 10.90 5 196808 6127 42418395
Iris disorder 14.61 10.90 9 196804 144 42424378
Product use complaint 14.57 10.90 32 196781 2199 42422323
Burning feet syndrome 14.56 10.90 8 196805 102 42424420
Graft versus host disease in gastrointestinal tract 14.54 10.90 3 196810 5140 42419382
Abnormal dreams 14.49 10.90 76 196737 8195 42416327
Body temperature increased 14.43 10.90 47 196766 20311 42404211
Drug withdrawal syndrome 14.42 10.90 51 196762 21498 42403024
Phaeochromocytoma malignant 14.39 10.90 7 196806 68 42424454
Substance abuse 14.34 10.90 12 196801 8893 42415629
Back pain 14.31 10.90 796 196017 140980 42283542
Feeling drunk 14.31 10.90 32 196781 2226 42422296
Fluid intake reduced 14.23 10.90 46 196767 3986 42420536
Gingival pain 14.17 10.90 77 196736 8417 42416105
Catarrh 14.15 10.90 60 196753 5926 42418596
Colitis 14.13 10.90 142 196671 46430 42378092
Urethral pain 14.09 10.90 9 196804 154 42424368
Lymphoma 14.07 10.90 28 196785 14293 42410229
Product complaint 14.06 10.90 5 196808 5972 42418550
Foreign body in throat 14.05 10.90 15 196798 541 42423981
Arteriosclerotic gangrene 14.05 10.90 7 196806 72 42424450
Wrong patient 14 10.90 16 196797 623 42423899
Hepatic cytolysis 13.96 10.90 70 196743 26774 42397748
Resting tremor 13.92 10.90 20 196793 981 42423541
Electrocardiogram ST segment elevation 13.92 10.90 5 196808 5934 42418588
Mydriasis 13.90 10.90 12 196801 8758 42415764
Drug eruption 13.90 10.90 57 196756 23018 42401504
Embolic stroke 13.89 10.90 53 196760 4987 42419535
Multiple sclerosis relapse 13.86 10.90 113 196700 14151 42410371
Inferior vena cava dilatation 13.85 10.90 18 196795 802 42423720
Diabetic neuropathy 13.80 10.90 49 196764 4453 42420069
Hyperbilirubinaemia 13.70 10.90 49 196764 20586 42403936
Hypertriglyceridaemia 13.60 10.90 16 196797 10110 42414412
Blood albumin decreased 13.57 10.90 32 196781 15370 42409152
Ageusia 13.56 10.90 96 196717 11509 42413013
Treatment noncompliance 13.55 10.90 110 196703 37562 42386960
Diverticulum intestinal 13.47 10.90 53 196760 5060 42419462
Dental restoration failure 13.41 10.90 5 196808 23 42424499
Musculoskeletal stiffness 13.34 10.90 187 196626 57578 42366944
Aortic dilatation 13.32 10.90 26 196787 1643 42422879
Mouth swelling 13.32 10.90 31 196782 2215 42422307
Iron deficiency 13.29 10.90 19 196794 11042 42413480
Viral infection 13.26 10.90 56 196757 22427 42402095
Myocarditis 13.23 10.90 44 196769 18894 42405628
Pharyngeal cancer 13.23 10.90 6 196807 49 42424473
Peritonitis 13.22 10.90 43 196770 18590 42405932
Enterococcal infection 13.20 10.90 22 196791 12017 42412505
Lung infiltration 13.19 10.90 28 196785 13961 42410561
Drug level decreased 13.15 10.90 16 196797 9961 42414561
Chronic coronary syndrome 13.15 10.90 11 196802 290 42424232
Sepsis 13.09 10.90 770 196043 198564 42225958
Haemolysis 13.04 10.90 15 196798 9574 42414948
Drug level below therapeutic 12.99 10.90 7 196806 6538 42417984
Weight decreased 12.99 10.90 1122 195691 206826 42217696
Acidosis 12.95 10.90 23 196790 12256 42412266
Hepatic enzyme increased 12.91 10.90 142 196671 45642 42378880
Subdural hygroma 12.87 10.90 13 196800 439 42424083
Oesophageal rupture 12.82 10.90 13 196800 441 42424081
Periorbital haematoma 12.80 10.90 12 196801 369 42424153
Hypogammaglobulinaemia 12.79 10.90 22 196791 11869 42412653
Femoral artery aneurysm 12.79 10.90 9 196804 182 42424340
Iridocele 12.76 10.90 5 196808 27 42424495
Medical device site haemorrhage 12.72 10.90 8 196805 133 42424389
Restless legs syndrome 12.71 10.90 82 196731 9532 42414990
Euphoric mood 12.66 10.90 7 196806 6446 42418076
Respiratory failure 12.60 10.90 474 196339 127658 42296864
Stomal hernia 12.56 10.90 12 196801 378 42424144
Sopor 12.52 10.90 104 196709 13098 42411424
Dacryostenosis acquired 12.50 10.90 11 196802 311 42424211
Flushing 12.47 10.90 110 196703 36918 42387604
Therapeutic product effect decreased 12.45 10.90 118 196695 39032 42385490
Wound haematoma 12.45 10.90 6 196807 57 42424465
Liver function test abnormal 12.39 10.90 93 196720 32298 42392224
Renal cyst 12.29 10.90 84 196729 9955 42414567
Testicular pain 12.28 10.90 38 196775 3216 42421306
Pulmonary tuberculosis 12.28 10.90 5 196808 5496 42419026
Device related infection 12.27 10.90 50 196763 20229 42404293
C-reactive protein increased 12.23 10.90 213 196600 63347 42361175
Emotional distress 12.23 10.90 36 196777 16057 42408465
IgA nephropathy 12.19 10.90 31 196782 2343 42422179
Keratoacanthoma 12.18 10.90 18 196795 906 42423616
Drug dose omission by device 12.12 10.90 6 196807 5880 42418642
Autoimmune myositis 12.12 10.90 15 196798 636 42423886
Inflammation 12.10 10.90 99 196714 33748 42390774
Uveitis 12.04 10.90 15 196798 9243 42415279
Inadequate osteointegration 12.04 10.90 4 196809 12 42424510
Paraplegia 11.98 10.90 38 196775 3259 42421263
Generalised tonic-clonic seizure 11.96 10.90 72 196741 26307 42398215
Condition aggravated 11.94 10.90 1039 195774 259715 42164807
Blood 25-hydroxycholecalciferol decreased 11.90 10.90 11 196802 332 42424190
Alanine aminotransferase abnormal 11.86 10.90 4 196809 4940 42419582
Aortic arteriosclerosis 11.85 10.90 51 196762 5069 42419453
Wrong schedule 11.85 10.90 11 196802 334 42424188
Visual field defect 11.84 10.90 4 196809 4934 42419588
No adverse event 11.83 10.90 119 196694 38902 42385620
Gastrointestinal pain 11.82 10.90 46 196767 4369 42420153
Intestinal perforation 11.80 10.90 20 196793 10854 42413668
Umbilical hernia 11.66 10.90 53 196760 5394 42419128
Blood loss anaemia 11.65 10.90 81 196732 9655 42414867
Blood glucose fluctuation 11.64 10.90 47 196766 4540 42419982
Malaise 11.62 10.90 1134 195679 211022 42213500
Hydronephrosis 11.54 10.90 94 196719 11771 42412751
COVID-19 11.50 10.90 650 196163 115298 42309224
Staphylococcal sepsis 11.49 10.90 22 196791 11392 42413130
Urethral obstruction 11.47 10.90 9 196804 216 42424306
Bladder neoplasm 11.46 10.90 23 196790 1484 42423038
Gastrointestinal bacterial infection 11.41 10.90 15 196798 676 42423846
Alveolar bone resorption 11.37 10.90 4 196809 15 42424507
Dialysis 11.30 10.90 24 196789 11962 42412560
Faecaloma 11.25 10.90 58 196755 6212 42418310
Cerebral haemorrhage 11.20 10.90 247 196566 38719 42385803
Haematocrit decreased 11.19 10.90 105 196708 34803 42389719
Urinary straining 11.17 10.90 4 196809 16 42424506
Blood pressure systolic 11.17 10.90 4 196809 16 42424506
Device leakage 11.09 10.90 19 196794 10266 42414256
Sperm concentration zero 11.08 10.90 3 196810 3 42424519
Tendon pain 11.06 10.90 37 196776 3263 42421259
Internal haemorrhage 11.05 10.90 52 196761 5369 42419153
Haemodialysis 11.02 10.90 19 196794 10241 42414281
Pericarditis 11.01 10.90 29 196784 13415 42411107
Skin atrophy 10.97 10.90 31 196782 2494 42422028
Central nervous system lesion 10.95 10.90 68 196745 7802 42416720
Blood urine present 10.90 10.90 92 196721 11641 42412881

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Urinary retention 507.23 10.71 595 178673 69088 110340943
Benign prostatic hyperplasia 429.64 10.71 302 178966 17932 110392099
Syncope 424.51 10.71 983 178285 201553 110208478
Fall 415.78 10.71 2006 177262 601476 109808555
Maternal exposure during pregnancy 391.09 10.71 4 179264 254879 110155152
Synovitis 389.49 10.71 12 179256 274080 110135951
Atrial fibrillation 367.50 10.71 1006 178262 228636 110181395
Haematuria 349.59 10.71 543 178725 82462 110327569
Orthostatic hypotension 343.49 10.71 478 178790 65771 110344260
Alopecia 330.67 10.71 91 179177 364662 110045369
Drug intolerance 304.41 10.71 139 179129 406373 110003658
Death 299.85 10.71 2048 177220 696821 109713210
Drug ineffective 287.70 10.71 1380 177888 1519160 108890871
Hypotension 286.39 10.71 1634 177634 522215 109887816
Pemphigus 279.82 10.71 17 179251 214553 110195478
Dizziness 274.91 10.71 2004 177264 696189 109713842
Duodenal ulcer perforation 267.17 10.71 4 179264 177696 110232335
Product prescribing error 264.04 10.71 369 178899 50962 110359069
Glossodynia 263.26 10.71 27 179241 221977 110188054
Joint swelling 261.74 10.71 201 179067 442644 109967387
Pericarditis 261.51 10.71 26 179242 219088 110190943
Treatment failure 255.30 10.71 67 179201 277167 110132864
Dysuria 243.84 10.71 387 178881 59844 110350187
Helicobacter infection 232.42 10.71 16 179252 181861 110228170
Idiopathic pulmonary fibrosis 227.77 10.71 126 179142 4878 110405153
Infusion related reaction 226.48 10.71 172 179096 380990 110029041
Bradycardia 222.96 10.71 655 178613 154862 110255169
Fibromyalgia 221.45 10.71 14 179254 170895 110239136
Arthropathy 217.21 10.71 97 179171 287425 110122606
Erectile dysfunction 216.68 10.71 204 179064 18352 110391679
Nocturia 216.26 10.71 196 179072 16794 110393237
Drug hypersensitivity 215.70 10.71 251 179017 453839 109956192
Micturition urgency 211.56 10.71 205 179063 19115 110390916
Folliculitis 207.83 10.71 17 179251 167636 110242395
Systemic lupus erythematosus 206.40 10.71 77 179191 254261 110155770
Hepatic enzyme increased 202.14 10.71 136 179132 320756 110089275
Pulmonary vasculitis 196.17 10.71 126 179142 6434 110403597
Rheumatoid arthritis 188.69 10.71 127 179141 299486 110110545
Obstructive airways disorder 187.45 10.71 297 178971 45852 110364179
Hypersensitivity 185.78 10.71 229 179039 403769 110006262
Acute kidney injury 181.54 10.71 1697 177571 633733 109776298
Muscle injury 178.13 10.71 13 179255 140794 110269237
Presyncope 176.09 10.71 298 178970 48589 110361442
Stomatitis 173.61 10.71 112 179156 270130 110139901
Irritable bowel syndrome 173.06 10.71 29 179239 164186 110245845
Therapeutic product effect decreased 172.95 10.71 90 179178 244226 110165805
Psoriatic arthropathy 172.84 10.71 52 179216 196709 110213322
Full blood count abnormal 172.62 10.71 319 178949 55733 110354298
Swelling 172.13 10.71 189 179079 350852 110059179
Pollakiuria 169.36 10.71 277 178991 43918 110366113
Impaired healing 167.42 10.71 55 179213 196662 110213369
Discomfort 161.24 10.71 73 179195 214634 110195397
Neuritis 148.01 10.71 111 179157 7288 110402743
Bronchiectasis 142.92 10.71 231 179037 36262 110373769
Total lung capacity abnormal 141.94 10.71 90 179178 4493 110405538
Prostate cancer 140.29 10.71 233 179035 37408 110372623
Urinary tract infection 139.91 10.71 957 178311 325325 110084706
Ill-defined disorder 136.76 10.71 42 179226 156811 110253220
Congenital hiatus hernia 136.69 10.71 99 179169 6160 110403871
Sinusitis 136.51 10.71 168 179100 296520 110113511
Joint range of motion decreased 134.10 10.71 19 179249 121813 110288218
Injury 131.95 10.71 61 179207 177204 110232827
Dyspnoea exertional 131.08 10.71 419 178849 103641 110306390
Hallucination 129.21 10.71 410 178858 101022 110309009
Lip dry 124.44 10.71 10 179258 100073 110309958
Blood cholesterol increased 123.62 10.71 73 179195 184712 110225319
Dyspnoea 122.24 10.71 2492 176776 1104380 109305651
Musculoskeletal stiffness 121.97 10.71 165 179103 279657 110130374
Product monitoring error 121.57 10.71 107 179161 8820 110401211
Contraindicated product administered 121.29 10.71 134 179134 248133 110161898
Bursitis 118.39 10.71 32 179236 129886 110280145
Malignant melanoma in situ 118.37 10.71 73 179195 3469 110406562
Urinary incontinence 117.60 10.71 250 179018 48337 110361694
Prostatic specific antigen increased 115.43 10.71 121 179147 12390 110397641
Right atrial hypertrophy 114.98 10.71 43 179225 648 110409383
Haematochezia 114.04 10.71 429 178839 115095 110294936
Respiratory symptom 112.67 10.71 130 179138 14815 110395216
Inflammation 112.39 10.71 89 179179 193149 110216882
Prostatomegaly 111.09 10.71 75 179193 4167 110405864
Wound 110.75 10.71 130 179138 234307 110175724
Eosinophilic granulomatosis with polyangiitis 110.68 10.71 110 179158 10576 110399455
Neurological symptom 109.74 10.71 131 179137 15477 110394554
Labelled drug-drug interaction medication error 108.69 10.71 181 179087 29121 110380910
Prostatitis 107.27 10.71 77 179191 4724 110405307
Gastrointestinal disorder 107.14 10.71 141 179127 241811 110168220
Pulmonary alveolar haemorrhage 106.81 10.71 147 179121 20003 110390028
Spirometry abnormal 106.71 10.71 81 179187 5416 110404615
Peripheral venous disease 105.72 10.71 8 179260 84109 110325922
Priapism 104.25 10.71 82 179186 5779 110404252
Vomiting 103.01 10.71 962 178306 909713 109500318
Nephrolithiasis 100.74 10.71 285 178983 65927 110344104
Needle fatigue 99.17 10.71 46 179222 1218 110408813
Blister 99.15 10.71 134 179134 227242 110182789
Conjunctivitis allergic 98.26 10.71 85 179183 6846 110403185
Pain 97.09 10.71 1035 178233 953920 109456111
Retrograde ejaculation 96.46 10.71 33 179235 378 110409653
Lower respiratory tract infection 95.54 10.71 154 179114 242952 110167079
Urogenital haemorrhage 94.52 10.71 41 179227 923 110409108
Mite allergy 92.21 10.71 76 179192 5727 110404304
Chronic obstructive pulmonary disease 92.14 10.71 386 178882 108772 110301259
Grip strength decreased 91.84 10.71 11 179257 80163 110329868
Liver injury 90.36 10.71 67 179201 150346 110259685
Gait spastic 90.28 10.71 46 179222 1503 110408528
Myelosuppression 88.32 10.71 22 179246 94318 110315713
Arthralgia 87.91 10.71 824 178444 778808 109631223
Hypertonic bladder 87.53 10.71 71 179197 5231 110404800
Urticaria 86.95 10.71 248 179020 318609 110091422
Anaemia 86.06 10.71 1304 177964 545782 109864249
Antineutrophil cytoplasmic antibody positive 85.97 10.71 69 179199 5007 110405024
Right ventricular hypertrophy 85.77 10.71 46 179222 1673 110408358
Floppy iris syndrome 85.33 10.71 29 179239 325 110409706
Type 2 diabetes mellitus 85.08 10.71 97 179171 177135 110232896
Drug interaction 84.47 10.71 1207 178061 498976 109911055
Dust allergy 83.87 10.71 73 179195 5928 110404103
Osteoarthritis 82.30 10.71 105 179163 182518 110227513
Subdural haematoma 81.87 10.71 182 179086 36272 110373759
Nightmare 81.69 10.71 189 179079 38674 110371357
Asthenia 81.41 10.71 1568 177700 687431 109722600
Plasma cell myeloma 80.69 10.71 255 179013 62681 110347350
Mycotic allergy 80.35 10.71 71 179197 5883 110404148
Wound infection 80.26 10.71 28 179240 96437 110313594
Loss of consciousness 79.48 10.71 568 178700 195738 110214293
Drug abuse 77.90 10.71 104 179164 177307 110232724
Relapsing-remitting multiple sclerosis 77.54 10.71 46 179222 2036 110407995
Nasopharyngitis 76.87 10.71 353 178915 394008 110016023
Productive cough 74.77 10.71 375 178893 113930 110296101
Vertigo 74.73 10.71 309 178959 86561 110323470
Weight increased 74.65 10.71 388 178880 419256 109990775
Forced expiratory volume decreased 74.21 10.71 99 179169 13077 110396954
Toxicity to various agents 73.83 10.71 466 178802 480089 109929942
Haemoptysis 73.77 10.71 269 178999 71085 110338946
Therapy non-responder 73.45 10.71 88 179180 157219 110252812
Burns second degree 71.72 10.71 75 179193 7658 110402373
Sciatica 71.58 10.71 30 179238 92369 110317662
Confusional state 71.31 10.71 1111 178157 467569 109942462
Autoimmune disorder 68.02 10.71 12 179256 65471 110344560
Abdominal discomfort 67.35 10.71 369 178899 393489 110016542
Cardiac failure 66.97 10.71 527 178741 187099 110222932
Dehydration 66.76 10.71 720 178548 278791 110131240
Blepharospasm 66.76 10.71 6 179262 54845 110355186
Acquired haemophilia 65.30 10.71 45 179223 2586 110407445
Systemic infection 65.10 10.71 80 179188 9739 110400292
Loss of personal independence in daily activities 64.79 10.71 441 178827 149579 110260452
Myoglobin blood increased 64.28 10.71 54 179214 4178 110405853
Catarrh 64.23 10.71 69 179199 7266 110402765
Distributive shock 63.42 10.71 62 179206 5842 110404189
Product use issue 63.13 10.71 275 178993 311420 110098611
Breath sounds abnormal 62.96 10.71 132 179136 25272 110384759
Night sweats 62.50 10.71 75 179193 133908 110276123
Pulmonary function test abnormal 62.29 10.71 57 179211 4943 110405088
Headache 62.26 10.71 1031 178237 881346 109528685
COVID-19 62.16 10.71 639 178629 244421 110165610
Infection 61.56 10.71 340 178928 361860 110048171
Drug resistance 61.54 10.71 9 179259 56365 110353666
Onychomadesis 61.42 10.71 3 179265 45660 110364371
Injection site reaction 61.25 10.71 34 179234 89036 110320995
Urosepsis 61.01 10.71 146 179122 30529 110379502
Nausea 60.15 10.71 1535 177733 1234155 109175876
Fractional exhaled nitric oxide increased 60.14 10.71 28 179240 748 110409283
Red blood cell sedimentation rate increased 59.73 10.71 26 179242 78276 110331755
Adjustment disorder with depressed mood 58.65 10.71 3 179265 43880 110366151
Cerebral haemorrhage 58.18 10.71 234 179034 64734 110345297
Balance disorder 57.91 10.71 355 178913 116205 110293826
Urine flow decreased 57.48 10.71 33 179235 1373 110408658
Migraine 57.40 10.71 120 179148 171532 110238499
Nail disorder 57.24 10.71 12 179256 57923 110352108
Haematoma 56.73 10.71 216 179052 58260 110351771
Steroid dependence 56.15 10.71 69 179199 8400 110401631
Hospice care 55.86 10.71 84 179184 12389 110397642
Normochromic normocytic anaemia 55.75 10.71 86 179182 12971 110397060
Interstitial lung disease 55.71 10.71 402 178866 138932 110271099
Mobility decreased 55.37 10.71 198 179070 237224 110172807
IVth nerve paralysis 54.89 10.71 25 179243 634 110409397
Coeliac disease 54.57 10.71 4 179264 43183 110366848
Aortic valve stenosis 54.32 10.71 59 179209 6291 110403740
Dementia 53.82 10.71 142 179126 31531 110378500
Dysgeusia 53.32 10.71 240 179028 69745 110340286
Pemphigoid 53.10 10.71 106 179162 19601 110390430
Bronchial wall thickening 53.05 10.71 43 179225 3164 110406867
Inappropriate antidiuretic hormone secretion 52.75 10.71 147 179121 33704 110376327
Constipation 52.06 10.71 842 178426 356944 110053087
Arteriosclerosis 51.56 10.71 120 179148 24647 110385384
Cerebrovascular accident 51.46 10.71 484 178784 180800 110229231
Upper gastrointestinal haemorrhage 51.05 10.71 188 179080 49908 110360123
Parosmia 51.01 10.71 83 179185 13097 110396934
Transient ischaemic attack 49.94 10.71 221 179047 63761 110346270
Radiation inflammation 49.38 10.71 27 179241 1021 110409010
Monoparesis 49.26 10.71 48 179220 4505 110405526
General physical health deterioration 49.14 10.71 965 178303 424330 109985701
Hypopnoea 48.65 10.71 75 179193 11305 110398726
Lower limb fracture 47.30 10.71 32 179236 75316 110334715
Liver disorder 47.09 10.71 100 179168 142143 110267888
Pneumonia 46.45 10.71 1798 177470 874916 109535115
Bladder cancer 46.34 10.71 102 179166 20190 110389841
Hyponatraemia 46.22 10.71 548 178720 217105 110192926
Guillain-Barre syndrome 46.20 10.71 71 179197 10673 110399358
Oesophageal ulcer haemorrhage 46.17 10.71 25 179243 927 110409104
Urinary tract obstruction 45.86 10.71 49 179219 5128 110404903
Atrioventricular block 45.74 10.71 91 179177 16786 110393245
Renal cyst haemorrhage 45.52 10.71 23 179245 738 110409293
Capillaritis 45.28 10.71 35 179233 2404 110407627
Renal impairment 45.24 10.71 486 178782 187959 110222072
Hydronephrosis 45.09 10.71 102 179166 20563 110389468
Lower urinary tract symptoms 44.70 10.71 20 179248 486 110409545
Perineal pain 44.53 10.71 29 179239 1516 110408515
Genital swelling 44.29 10.71 19 179249 416 110409615
Road traffic accident 44.11 10.71 66 179202 107332 110302699
Arteriosclerosis coronary artery 44.10 10.71 114 179154 25004 110385027
Obesity 43.39 10.71 73 179195 113278 110296753
Obstruction 43.30 10.71 50 179218 5702 110404329
Orbital myositis 43.28 10.71 16 179252 233 110409798
Troponin increased 43.21 10.71 126 179142 29640 110380391
Thrombosis 43.14 10.71 313 178955 108349 110301682
Vasculitis 42.95 10.71 142 179126 35731 110374300
Testicular swelling 42.39 10.71 29 179239 1647 110408384
Product substitution issue 41.87 10.71 106 179162 22955 110387076
Bronchial secretion retention 41.79 10.71 46 179222 4978 110405053
Diastolic dysfunction 41.24 10.71 73 179195 12331 110397700
Arrhythmia 41.16 10.71 222 179046 69353 110340678
Off label use 40.58 10.71 2004 177264 1498181 108911850
Pulmonary embolism 40.38 10.71 528 178740 213946 110196085
Faeces discoloured 40.30 10.71 134 179134 33814 110376217
Rectal haemorrhage 40.25 10.71 332 178936 119501 110290530
Head injury 40.17 10.71 157 179111 42860 110367171
Hepatic vein dilatation 39.93 10.71 15 179253 229 110409802
Multiple organ dysfunction syndrome 39.87 10.71 120 179148 151590 110258441
Lupus-like syndrome 39.19 10.71 9 179259 40783 110369248
Drug dependence 39.13 10.71 16 179252 50004 110360027
Abdominal pain lower 38.91 10.71 141 179127 37142 110372889
Dry mouth 38.90 10.71 179 179089 199769 110210262
Gout 38.76 10.71 139 179129 36427 110373604
Intentional product use issue 38.74 10.71 239 179029 247667 110162364
Injection site erythema 38.56 10.71 58 179210 94118 110315913
Hypoacusis 38.36 10.71 135 179133 35056 110374975
Arteriovenous fistula 38.28 10.71 26 179242 1459 110408572
Gingival pain 38.11 10.71 81 179187 15655 110394376
Sepsis 37.53 10.71 742 178526 326604 110083427
Gastrointestinal haemorrhage 37.49 10.71 422 178846 165096 110244935
Dizziness postural 37.48 10.71 77 179191 14532 110395499
Hip arthroplasty 37.38 10.71 22 179246 55791 110354240
Micturition disorder 37.33 10.71 42 179226 4656 110405375
Abdominal wall haemorrhage 37.15 10.71 20 179248 733 110409298
Prostatic operation 37.10 10.71 16 179252 355 110409676
Finger deformity 36.79 10.71 5 179263 33087 110376944
Injection site pain 36.60 10.71 156 179112 177766 110232265
Onychomycosis 36.03 10.71 9 179259 38522 110371509
Prostatic disorder 36.03 10.71 31 179237 2478 110407553
Pallor 36.03 10.71 184 179084 56283 110353748
Device expulsion 35.97 10.71 4 179264 30887 110379144
Ejaculation disorder 35.96 10.71 18 179250 566 110409465
Haematemesis 35.91 10.71 190 179078 58918 110351113
Back injury 35.74 10.71 16 179252 47383 110362648
Hepatitis 35.40 10.71 57 179211 89997 110320034
SARS-CoV-2 antibody test positive 35.38 10.71 16 179252 399 110409632
Testicular pain 34.86 10.71 30 179238 2399 110407632
Liver palpable 34.65 10.71 15 179253 336 110409695
Vena cava injury 34.61 10.71 15 179253 337 110409694
Hyperkalaemia 34.36 10.71 354 178914 135442 110274589
Bladder catheterisation 34.13 10.71 22 179246 1130 110408901
Hypoaesthesia 34.07 10.71 335 178933 313888 110096143
Oedema peripheral 34.07 10.71 734 178534 327926 110082105
Hot flush 33.98 10.71 203 179065 65833 110344198
Umbilical hernia 33.91 10.71 49 179219 6973 110403058
Ear infection 33.88 10.71 31 179237 62701 110347330
Malignant spinal cord compression 33.84 10.71 12 179256 154 110409877
Hyperthyroidism 33.41 10.71 114 179154 29147 110380884
Ejaculation failure 33.21 10.71 15 179253 373 110409658
Inguinal hernia 33.15 10.71 51 179217 7674 110402357
Gynaecomastia 33.04 10.71 57 179211 9433 110400598
Vascular anastomotic haemorrhage 32.95 10.71 14 179254 299 110409732
Ear pain 32.88 10.71 23 179245 53203 110356828
Plasmapheresis 32.78 10.71 19 179249 805 110409226
Carotid arteriosclerosis 32.65 10.71 32 179236 3025 110407006
Urinary hesitation 32.59 10.71 39 179229 4619 110405412
C-reactive protein increased 32.55 10.71 213 179055 217706 110192325
Laryngitis 32.48 10.71 14 179254 42397 110367634
Breast cancer 32.38 10.71 11 179257 38531 110371500
Hallucination, visual 31.82 10.71 138 179130 39467 110370564
Bladder neck obstruction 31.68 10.71 10 179258 87 110409944
Haematospermia 31.48 10.71 13 179255 258 110409773
Alcohol poisoning 31.18 10.71 54 179214 8966 110401065
Drug ineffective for unapproved indication 31.03 10.71 76 179192 102762 110307269
Cataract operation complication 30.85 10.71 13 179255 272 110409759
Platypnoea 30.59 10.71 8 179260 32 110409999
Rhinitis 30.42 10.71 93 179175 22452 110387579
Platelet distribution width increased 30.35 10.71 11 179257 151 110409880
Foot deformity 29.88 10.71 21 179247 48459 110361572
IgA nephropathy 29.83 10.71 31 179237 3142 110406889
COVID-19 pneumonia 29.52 10.71 129 179139 37014 110373017
Coronary artery disease 29.32 10.71 208 179060 71482 110338549
Angina pectoris 29.23 10.71 187 179081 62108 110347923
Bladder spasm 29.05 10.71 29 179239 2803 110407228
Mean cell volume increased 28.96 10.71 50 179218 8280 110401751
Tendon pain 28.90 10.71 43 179225 6283 110403748
Prostatic mass 28.31 10.71 7 179261 21 110410010
Haemoglobin decreased 28.23 10.71 563 178705 248164 110161867
Cardiac disorder 28.16 10.71 216 179052 76064 110333967
Blood pressure decreased 28.16 10.71 298 178970 114793 110295238
Genital pain 28.00 10.71 21 179247 1379 110408652
Central nervous system lesion 27.73 10.71 71 179197 15482 110394549
Suicide attempt 27.73 10.71 81 179187 103313 110306718
Brain natriuretic peptide increased 27.49 10.71 58 179210 11151 110398880
Musculoskeletal pain 27.28 10.71 179 179089 182844 110227187
Cardiac amyloidosis 27.18 10.71 28 179240 2809 110407222
Diverticulum intestinal haemorrhagic 27.15 10.71 36 179232 4727 110405304
Prostatic varices 27.13 10.71 5 179263 0 110410031
Urinary tract disorder 27.09 10.71 40 179228 5804 110404227
Chronic kidney disease 27.04 10.71 214 179054 76077 110333954
Chest X-ray abnormal 27.00 10.71 49 179219 8438 110401593
Testicular infarction 26.87 10.71 8 179260 56 110409975
Blood loss anaemia 26.84 10.71 77 179191 17948 110392083
Aortic dilatation 26.81 10.71 25 179243 2221 110407810
Plantar fasciitis 26.71 10.71 37 179231 5064 110404967
Sleep disorder due to a general medical condition 26.69 10.71 160 179108 51952 110358079
Tachyarrhythmia 26.67 10.71 48 179220 8213 110401818
Red blood cell sedimentation rate abnormal 26.55 10.71 4 179264 24505 110385526
Cardiac failure congestive 26.46 10.71 367 178901 150633 110259398
Weight decreased 26.40 10.71 967 178301 467090 109942941
Prostate cancer metastatic 26.10 10.71 36 179232 4907 110405124
Prostate tenderness 26.05 10.71 8 179260 63 110409968
Disorientation 26.03 10.71 200 179068 70471 110339560
Perineal cyst 25.98 10.71 11 179257 233 110409798
Embolic stroke 25.96 10.71 49 179219 8694 110401337
Paraesthesia 25.87 10.71 305 178963 276216 110133815
Dysphagia 25.59 10.71 370 178898 153230 110256801
Intestinal haemorrhage 25.44 10.71 44 179224 7297 110402734
Dacryocystitis 25.28 10.71 9 179259 117 110409914
Inferior vena cava dilatation 25.09 10.71 17 179251 950 110409081
Joint dislocation 25.07 10.71 12 179256 34178 110375853
Melaena 25.00 10.71 194 179074 68563 110341468
Tinnitus 24.96 10.71 176 179092 60364 110349667
Renal haematoma 24.84 10.71 17 179251 966 110409065
Injection site pruritus 24.64 10.71 28 179240 51230 110358801
Respiratory disorder 24.62 10.71 49 179219 71333 110338698
Swollen tongue 24.60 10.71 175 179093 60187 110349844
Epilepsy 24.40 10.71 82 179186 100127 110309904
Benign gastrointestinal neoplasm 24.35 10.71 9 179259 131 110409900
Therapeutic response decreased 24.17 10.71 78 179190 96421 110313610
Resting tremor 24.16 10.71 21 179247 1702 110408329
Circulatory collapse 23.96 10.71 135 179133 42858 110367173
Paraplegia 23.94 10.71 39 179229 6161 110403870
Sleep apnoea syndrome 23.88 10.71 129 179139 40318 110369713
Gait inability 23.70 10.71 127 179141 136249 110273782
Hip fracture 23.45 10.71 116 179152 35035 110374996
Cardiac failure acute 23.40 10.71 89 179179 23989 110386042
Vascular compression 23.35 10.71 15 179253 766 110409265
Hyperglycaemia 23.05 10.71 225 179043 84865 110325166
Diabetic neuropathy 23.02 10.71 41 179227 6958 110403073
Upper respiratory tract infection 22.99 10.71 122 179146 131206 110278825
Therapy partial responder 22.91 10.71 16 179252 37045 110372986
Epididymitis 22.87 10.71 24 179244 2460 110407571
Polyuria 22.85 10.71 72 179196 17666 110392365
Suprapubic pain 22.78 10.71 17 179251 1108 110408923
Shock haemorrhagic 22.71 10.71 96 179172 27151 110382880
Abdominal pain upper 22.57 10.71 414 178854 348697 110061334
Bladder obstruction 22.53 10.71 13 179255 546 110409485
Hypothyroidism 22.38 10.71 198 179070 72701 110337330
Cardiac murmur 22.28 10.71 89 179179 24539 110385492
Tongue dry 22.24 10.71 18 179250 1322 110408709
Intervertebral disc degeneration 22.02 10.71 72 179196 18013 110392018
Hepatic cirrhosis 21.99 10.71 48 179220 67578 110342453
Ageusia 21.96 10.71 76 179192 19569 110390462
Large intestine polyp 21.95 10.71 64 179204 15053 110394978
Ventricular enlargement 21.88 10.71 14 179254 710 110409321
Serum ferritin abnormal 21.87 10.71 12 179256 457 110409574
Cytomegalovirus infection 21.83 10.71 34 179234 54410 110355621
Injection site erosion 21.82 10.71 9 179259 178 110409853
Renal cyst 21.81 10.71 72 179196 18100 110391931
Tendon discomfort 21.66 10.71 13 179255 588 110409443
Vitreous loss 21.66 10.71 5 179263 10 110410021
Puncture site haematoma 21.59 10.71 10 179258 264 110409767
Disability 21.57 10.71 11 179257 30212 110379819
Subdural hygroma 21.56 10.71 13 179255 593 110409438
Phaeochromocytoma malignant 21.49 10.71 7 179261 68 110409963
Blood creatinine increased 21.43 10.71 416 178852 182473 110227558
Abnormal dreams 21.41 10.71 57 179211 12723 110397308
Iris haemorrhage 21.33 10.71 5 179263 11 110410020
Left ventricular hypertrophy 21.12 10.71 58 179210 13186 110396845
Lower gastrointestinal haemorrhage 21.09 10.71 72 179196 18414 110391617
Factitious disorder 21.02 10.71 9 179259 196 110409835
Arteriosclerotic gangrene 20.97 10.71 7 179261 74 110409957
Scrotal infection 20.93 10.71 14 179254 766 110409265
Rapid eye movement sleep behaviour disorder 20.92 10.71 13 179255 626 110409405
Metastatic lymphoma 20.87 10.71 13 179255 629 110409402
Idiopathic interstitial pneumonia 20.85 10.71 14 179254 771 110409260
Clostridium test positive 20.75 10.71 51 179217 10842 110399189
Renal colic 20.73 10.71 26 179242 3232 110406799
Sedation 20.63 10.71 52 179216 69631 110340400
Haemorrhagic stroke 20.62 10.71 59 179209 13730 110396301
Hemiparaesthesia 20.59 10.71 11 179257 397 110409634
Wrong patient received product 20.56 10.71 38 179230 6636 110403395
Fluid intake reduced 20.55 10.71 39 179229 6947 110403084
Rectal prolapse 20.52 10.71 23 179245 2540 110407491
Penile swelling 20.51 10.71 14 179254 792 110409239
Cerebral haematoma 20.41 10.71 47 179221 9585 110400446
Incorrect route of product administration 20.40 10.71 46 179222 64015 110346016
Femoral artery aneurysm 20.22 10.71 9 179259 216 110409815
Flatulence 20.00 10.71 149 179119 52000 110358031
Autoimmune myositis 19.98 10.71 15 179253 986 110409045
Food allergy 19.98 10.71 4 179264 19944 110390087
Mucosal inflammation 19.95 10.71 84 179184 96057 110313974
Liver function test increased 19.87 10.71 75 179193 88473 110321558
Intraductal papillary mucinous neoplasm 19.71 10.71 14 179254 845 110409186
Faecaloma 19.65 10.71 61 179207 14847 110395184
Somnolence 19.65 10.71 626 178642 296823 110113208
Haemophilus bacteraemia 19.63 10.71 9 179259 232 110409799
Milk-alkali syndrome 19.59 10.71 20 179248 1985 110408046
Perineal infection 19.59 10.71 14 179254 853 110409178
Delayed graft function 19.54 10.71 29 179239 4228 110405803
Deep vein thrombosis 19.49 10.71 327 178941 139560 110270471
Hypoxia 19.25 10.71 306 178962 129209 110280822
Foreign body in throat 19.18 10.71 15 179253 1048 110408983
Atrial flutter 19.08 10.71 84 179184 24178 110385853
Residual urine volume increased 19.06 10.71 7 179261 100 110409931
Internal haemorrhage 19.03 10.71 47 179221 10024 110400007
Keratoacanthoma 19.01 10.71 17 179251 1431 110408600
Blood 25-hydroxycholecalciferol decreased 19.00 10.71 11 179257 465 110409566
Product quality issue 19.00 10.71 63 179205 77236 110332795
Orchitis 18.97 10.71 19 179249 1843 110408188
Infusion site reaction 18.89 10.71 3 179265 17679 110392352
Narrow anterior chamber angle 18.87 10.71 8 179260 170 110409861
Sudden death 18.83 10.71 84 179184 24311 110385720
Hypoglycaemia 18.67 10.71 278 178990 115826 110294205
Cardiac failure chronic 18.66 10.71 57 179211 13754 110396277
Optic nerve operation 18.62 10.71 11 179257 483 110409548
Mantle cell lymphoma 18.61 10.71 18 179250 1674 110408357
Amaurosis fugax 18.37 10.71 21 179247 2369 110407662
Atrial enlargement 18.13 10.71 15 179253 1136 110408895
Prostatism 18.11 10.71 7 179261 116 110409915
Chronic sinusitis 18.09 10.71 9 179259 25075 110384956
Actinic keratosis 18.03 10.71 37 179231 6976 110403055
Gastrointestinal vascular malformation haemorrhagic 18.03 10.71 14 179254 968 110409063
Adverse event 17.99 10.71 103 179165 108706 110301325
Diplopia 17.98 10.71 123 179145 41771 110368260
Mixed dementia 17.95 10.71 9 179259 284 110409747
Chronic coronary syndrome 17.84 10.71 9 179259 288 110409743
Penile pain 17.76 10.71 15 179253 1169 110408862
Haematotoxicity 17.74 10.71 6 179262 21076 110388955
Red blood cell count decreased 17.70 10.71 174 179094 65749 110344282
Cytomegalovirus infection reactivation 17.70 10.71 4 179264 18329 110391702
Accidental overdose 17.61 10.71 144 179124 51690 110358341
Urethral obstruction 17.58 10.71 9 179259 297 110409734
Aortic arteriosclerosis 17.54 10.71 48 179220 10890 110399141
Pharyngeal cancer 17.52 10.71 6 179262 69 110409962
Thrombotic microangiopathy 17.48 10.71 13 179255 29136 110380895
Sleep disorder 17.47 10.71 222 179046 198422 110211609
Ventricular fibrillation 17.34 10.71 25 179243 41288 110368743
Drug use disorder 17.34 10.71 4 179264 18070 110391961
Knee arthroplasty 17.33 10.71 51 179217 64897 110345134
Oedema 17.25 10.71 238 179030 209738 110200293
Electrocardiogram abnormal 17.24 10.71 68 179200 18641 110391390
Bladder discomfort 17.21 10.71 13 179255 863 110409168
Squamous cell carcinoma of skin 17.06 10.71 64 179204 17139 110392892
Bladder disorder 16.99 10.71 48 179220 11089 110398942
Restless legs syndrome 16.95 10.71 82 179186 24544 110385487
Scrotal pain 16.94 10.71 11 179257 572 110409459
Acute myocardial infarction 16.92 10.71 209 179059 83568 110326463
Bladder tamponade 16.89 10.71 12 179256 724 110409307
Pancreatitis 16.87 10.71 86 179182 93447 110316584
Posterior reversible encephalopathy syndrome 16.82 10.71 18 179250 33843 110376188
Blood glucose fluctuation 16.80 10.71 38 179230 7660 110402371
Multiple sclerosis relapse 16.76 10.71 139 179129 50101 110359930
Atrioventricular block first degree 16.75 10.71 56 179212 14169 110395862
Oesophageal rupture 16.68 10.71 13 179255 904 110409127
Prescribed overdose 16.67 10.71 79 179189 87502 110322529
Wrong patient 16.59 10.71 16 179252 1483 110408548
Pneumonia aspiration 16.56 10.71 203 179065 81030 110329001
Bone density decreased 16.53 10.71 3 179265 16039 110393992
Haemorrhage urinary tract 16.44 10.71 22 179246 2914 110407117
Anaphylactic reaction 16.42 10.71 113 179155 114187 110295844
Thermal burns of eye 16.41 10.71 7 179261 151 110409880
Palpitations 16.30 10.71 355 178913 158857 110251174
Sperm concentration zero 16.28 10.71 3 179265 0 110410031
Uveitis-glaucoma-hyphaema syndrome 16.28 10.71 3 179265 0 110410031
Platelet count decreased 16.28 10.71 489 178779 229954 110180077
Acute respiratory failure 16.18 10.71 190 179078 75070 110334961
Inadequate osteointegration 16.18 10.71 4 179264 12 110410019
Condition aggravated 16.16 10.71 1001 178267 733835 109676196
Ligament pain 16.15 10.71 8 179260 246 110409785
Injection site swelling 16.14 10.71 49 179219 61741 110348290
Herpes simplex 16.13 10.71 3 179265 15761 110394270
Lung neoplasm malignant 16.13 10.71 102 179166 33740 110376291
Burning feet syndrome 16.12 10.71 8 179260 247 110409784
Bulbar palsy 16.09 10.71 9 179259 356 110409675
Full blood count decreased 16.08 10.71 98 179170 32001 110378030
Body temperature increased 16.06 10.71 41 179227 54672 110355359
Rales 16.05 10.71 81 179187 24658 110385373
Respiratory tract haemorrhage 16.00 10.71 18 179250 1996 110408035
On and off phenomenon 15.97 10.71 27 179241 4397 110405634
Aspergillus infection 15.92 10.71 11 179257 25605 110384426
Erection increased 15.91 10.71 9 179259 364 110409667
Sensation of foreign body 15.90 10.71 38 179230 7937 110402094
Dyspepsia 15.85 10.71 216 179052 190749 110219282
Eczema 15.76 10.71 183 179085 72110 110337921
Joint injury 15.75 10.71 115 179153 39879 110370152
Atheroembolism 15.73 10.71 9 179259 372 110409659
Vision blurred 15.63 10.71 295 178973 128727 110281304
Rib fracture 15.61 10.71 101 179167 33669 110376362
Urinary bladder haemorrhage 15.58 10.71 21 179247 2801 110407230
Orthopnoea 15.37 10.71 46 179222 10975 110399056
Injection site bruising 15.37 10.71 38 179230 51225 110358806
Emotional distress 15.28 10.71 31 179237 44816 110365215
Drug tolerance 15.27 10.71 4 179264 16581 110393450
Rhabdomyolysis 15.18 10.71 277 178991 120124 110289907
Orthostatic intolerance 15.10 10.71 18 179250 2123 110407908
Palliative care 15.06 10.71 16 179252 1664 110408367
Joint stiffness 15.06 10.71 57 179211 67186 110342845
Urinary straining 15.05 10.71 5 179263 52 110409979
Cerebral infarction 15.00 10.71 139 179129 51699 110358332
Contusion 14.99 10.71 277 178991 233084 110176947
Renal stone removal 14.97 10.71 7 179261 189 110409842
Glomerular filtration rate decreased 14.89 10.71 89 179179 28867 110381164
Bladder neoplasm 14.88 10.71 17 179251 1917 110408114
Decreased vibratory sense 14.84 10.71 11 179257 709 110409322
Flushing 14.82 10.71 104 179164 104632 110305399
Prostate examination abnormal 14.80 10.71 7 179261 194 110409837
Complication associated with device 14.79 10.71 7 179261 20066 110389965
Gait disturbance 14.76 10.71 571 178697 277637 110132394
Febrile bone marrow aplasia 14.64 10.71 5 179263 17460 110392571
Forced expiratory flow decreased 14.64 10.71 8 179260 302 110409729
Impaired quality of life 14.63 10.71 91 179177 29926 110380105
Medical device site haemorrhage 14.63 10.71 7 179261 199 110409832
Hormone receptor positive breast cancer 14.63 10.71 10 179258 567 110409464
Cardiogenic shock 14.60 10.71 46 179222 57292 110352739
Muscle atrophy 14.58 10.71 51 179217 13203 110396828
Dysarthria 14.55 10.71 204 179064 83917 110326114
Altered state of consciousness 14.46 10.71 150 179118 57476 110352555
Aortic aneurysm 14.45 10.71 42 179226 9862 110400169
Tooth injury 14.41 10.71 18 179250 2228 110407803
Cornea verticillata 14.41 10.71 8 179260 312 110409719
Glycosylated haemoglobin increased 14.40 10.71 76 179192 23543 110386488
Aplastic anaemia 14.37 10.71 11 179257 24297 110385734
Urethral pain 14.37 10.71 10 179258 584 110409447
Haemophagocytic lymphohistiocytosis 14.36 10.71 18 179250 31541 110378490
Hospitalisation 14.35 10.71 317 178951 142176 110267855
Alcohol use disorder 14.33 10.71 5 179263 61 110409970
Bone marrow failure 14.32 10.71 47 179221 57801 110352230
Completed suicide 14.26 10.71 292 178976 242089 110167942
Iris disorder 14.20 10.71 7 179261 213 110409818
Device dislocation 14.16 10.71 94 179174 31610 110378421
Alanine aminotransferase increased 14.15 10.71 211 179057 183562 110226469
Intraventricular haemorrhage 14.10 10.71 29 179239 5478 110404553
Blood urine present 14.09 10.71 77 179191 24168 110385863
Prostatic abscess 14.08 10.71 10 179258 603 110409428
Blood glucose increased 14.06 10.71 297 178971 132199 110277832
Walking aid user 14.01 10.71 12 179256 25063 110384968
Disseminated Bacillus Calmette-Guerin infection 13.95 10.71 8 179260 332 110409699
Renal ischaemia 13.93 10.71 18 179250 2305 110407726
Panniculitis 13.89 10.71 4 179264 15578 110394453
Loss of libido 13.89 10.71 21 179247 3112 110406919
Ataxia 13.89 10.71 90 179178 30018 110380013
Brain oedema 13.88 10.71 18 179250 31080 110378951
Therapy cessation 13.85 10.71 122 179146 44735 110365296
Hyponatraemic syndrome 13.85 10.71 11 179257 786 110409245
Bradyarrhythmia 13.85 10.71 27 179241 4907 110405124
Flank pain 13.81 10.71 74 179194 23056 110386975
Sopor 13.78 10.71 104 179164 36442 110373589
Fatigue 13.74 10.71 2207 177061 1213751 109196280
Gastrointestinal bacterial infection 13.59 10.71 14 179254 1404 110408627
Rhinitis allergic 13.59 10.71 6 179262 17916 110392115
Paraesthesia oral 13.53 10.71 21 179247 33650 110376381
Prostatic obstruction 13.51 10.71 5 179263 73 110409958
Renal disorder 13.48 10.71 131 179137 49348 110360683
Fungal infection 13.48 10.71 40 179228 50766 110359265
International normalised ratio abnormal 13.45 10.71 31 179237 6326 110403705
Wound haemorrhage 13.39 10.71 26 179242 4712 110405319
Acne 13.38 10.71 21 179247 33499 110376532
Penis disorder 13.34 10.71 12 179256 1018 110409013
Diarrhoea 13.30 10.71 2072 177196 1137433 109272598
Neurogenic bladder 13.30 10.71 27 179241 5052 110404979
Middle ear inflammation 13.27 10.71 7 179261 246 110409785
Eosinophilia 13.24 10.71 148 179120 57788 110352243
Haematuria traumatic 13.23 10.71 8 179260 367 110409664
Immunodeficiency 13.10 10.71 27 179241 38811 110371220
Tenosynovitis 13.08 10.71 5 179263 16278 110393753
Sedation complication 13.05 10.71 8 179260 19847 110390184
Coma 13.04 10.71 125 179143 117744 110292287
Tubulointerstitial nephritis 13.01 10.71 140 179128 54144 110355887
Large intestinal obstruction 12.99 10.71 23 179245 3885 110406146
Injection site warmth 12.93 10.71 6 179262 17399 110392632
Muscle haemorrhage 12.92 10.71 32 179236 6837 110403194
Stent placement 12.87 10.71 33 179235 7201 110402830
Subdural haemorrhage 12.81 10.71 31 179237 6527 110403504
Diverticulum intestinal 12.81 10.71 45 179223 11674 110398357
Xanthelasma 12.79 10.71 6 179262 163 110409868
Calculus bladder 12.72 10.71 15 179253 1749 110408282
Muscular weakness 12.72 10.71 508 178760 247960 110162071
Oedema mucosal 12.66 10.71 17 179251 2259 110407772
Wrong schedule 12.65 10.71 10 179258 710 110409321
Wound haematoma 12.59 10.71 6 179262 169 110409862
Hypertensive crisis 12.59 10.71 75 179193 24297 110385734
Renal artery stenosis 12.48 10.71 22 179246 3704 110406327
Aortic stenosis 12.47 10.71 48 179220 13011 110397020
Transurethral prostatectomy 12.47 10.71 7 179261 279 110409752
Thoracic haemorrhage 12.47 10.71 7 179261 279 110409752
Drug dose omission by device 12.44 10.71 4 179264 14512 110395519
Infected dermal cyst 12.37 10.71 13 179255 1335 110408696
Renal scan abnormal 12.36 10.71 4 179264 38 110409993
Product size issue 12.36 10.71 11 179257 920 110409111
Bladder outlet obstruction 12.34 10.71 6 179262 177 110409854
Adverse reaction 12.33 10.71 18 179250 29576 110380455
Product impurity 12.31 10.71 5 179263 95 110409936
Executive dysfunction 12.31 10.71 8 179260 417 110409614
Albumin urine present 12.25 10.71 10 179258 743 110409288
Foot fracture 12.23 10.71 14 179254 25532 110384499
Atrioventricular block second degree 12.23 10.71 35 179233 8146 110401885
Spontaneous penile erection 12.22 10.71 6 179262 181 110409850
Post transplant lymphoproliferative disorder 12.20 10.71 5 179263 15608 110394423
Fractured skull depressed 12.18 10.71 4 179264 40 110409991
Cancer pain 12.16 10.71 31 179237 6741 110403290
Psoriasis 12.11 10.71 157 179111 139836 110270195
Choroidal detachment 12.04 10.71 10 179258 762 110409269
Cough 12.00 10.71 886 178382 460755 109949276
Blood glucose abnormal 11.94 10.71 47 179221 12869 110397162
Cytomegalovirus viraemia 11.90 10.71 7 179261 17757 110392274
Intervertebral disc space narrowing 11.85 10.71 15 179253 1881 110408150
Poisoning 11.84 10.71 18 179250 29087 110380944
Intentional self-injury 11.82 10.71 27 179241 37402 110372629
Graft versus host disease 11.78 10.71 8 179260 18798 110391233
International normalised ratio increased 11.78 10.71 202 179066 86570 110323461
Peripheral swelling 11.76 10.71 535 178733 403499 110006532
Prostatic haemorrhage 11.72 10.71 6 179262 198 110409833
Scrotal swelling 11.69 10.71 12 179256 1199 110408832
Joint effusion 11.68 10.71 10 179258 20895 110389136
Mucosal haemorrhage 11.66 10.71 19 179249 3001 110407030
Gastrointestinal pain 11.66 10.71 44 179224 11816 110398215
Malpositioned teeth 11.60 10.71 4 179264 47 110409984
Blood phosphorus increased 11.58 10.71 6 179262 16334 110393697
Gastrointestinal wall thinning 11.55 10.71 5 179263 112 110409919
Pneumothorax 11.44 10.71 97 179171 35188 110374843
Anal haemorrhage 11.43 10.71 25 179243 4927 110405104
Basosquamous carcinoma 11.43 10.71 5 179263 115 110409916
Oral herpes 11.41 10.71 26 179242 36054 110373977
Dysstasia 11.40 10.71 92 179176 32894 110377137
Periorbital haematoma 11.39 10.71 11 179257 1021 110409010
Urinary tract infection staphylococcal 11.38 10.71 11 179257 1022 110409009
Delirium 11.35 10.71 293 178975 134732 110275299
Product colour issue 11.34 10.71 11 179257 1027 110409004
Cogwheel rigidity 11.32 10.71 21 179247 3677 110406354
Coagulation factor VII level decreased 11.27 10.71 6 179262 215 110409816
Hiccups 11.24 10.71 46 179222 12823 110397208
Type 3 diabetes mellitus 11.23 10.71 5 179263 120 110409911
Pustular psoriasis 11.23 10.71 4 179264 13601 110396430
Respiratory failure 11.19 10.71 441 178827 214891 110195140
Amnesia 11.15 10.71 113 179155 105295 110304736
Akathisia 11.10 10.71 7 179261 17106 110392925
Mononuclear cell count abnormal 11.10 10.71 3 179265 14 110410017
Hypercholesterolaemia 11.07 10.71 94 179174 90743 110319288
Ureterolithiasis 11.06 10.71 23 179245 4379 110405652
Arthritis 11.05 10.71 198 179070 167388 110242643
Circadian rhythm sleep disorder 11.04 10.71 11 179257 1061 110408970
Heart rate irregular 10.99 10.71 94 179174 34180 110375851
Dacryostenosis acquired 10.96 10.71 9 179259 675 110409356
Epileptic encephalopathy 10.94 10.71 9 179259 676 110409355
Prostatic adenoma 10.94 10.71 5 179263 128 110409903
Biopsy prostate 10.93 10.71 3 179265 15 110410016
Dyspnoea at rest 10.86 10.71 34 179234 8312 110401719
Respiratory arrest 10.86 10.71 53 179215 58246 110351785
Bone disorder 10.83 10.71 11 179257 21181 110388850
Dry eye 10.81 10.71 50 179218 55743 110354288
Adenocarcinoma gastric 10.77 10.71 15 179253 2064 110407967
Aphthous ulcer 10.77 10.71 11 179257 21125 110388906
Amyloid related imaging abnormality-oedema/effusion 10.71 10.71 13 179255 1562 110408469
Unemployment 10.71 10.71 4 179264 60 110409971

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G04CA02 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
ATC G04CA52 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
ATC G04CA53 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
ATC G04CA54 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
FDA MoA N0000000099 Adrenergic alpha-Antagonists
FDA EPC N0000175553 alpha-Adrenergic Blocker
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists
MeSH PA D064804 Urological Agents
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:37890 ฮฑ-adrenergic antagonist
CHEBI has role CHEBI:35674 antihypertensive agent

Related Drugs by ATC class:

G04CA Alpha-adrenoreceptor antagonists 8 drugs
alfuzosindoxazosindutasteridefinasteridesilodosinsolifenacintadalafilterazosin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Benign prostatic hyperplasia indication 266569009
Priapism contraindication 6273006 DOID:9286
Orthostatic hypotension contraindication 28651003
Oligozoospermia contraindication 88311004
Cataract surgery contraindication 110473004
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Dizziness contraindication 404640003
Breastfeeding (mother) contraindication 413712001
Intraoperative floppy iris syndrome contraindication 418801006
High-Grade Prostate Cancer contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.71 acidic
pKa2 8.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 7.89 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.87 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 9.10 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 7.08 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 10.54 CHEMBL
D(3) dopamine receptor GPCR Ki 9.55 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 8.10 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 10.24 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 9.21 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 10.52 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 8.17 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 10.15 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 9.90 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 9.70 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.03 CHEMBL

External reference:

IDSource
4024076 VUID
N0000022081 NUI
D01024 KEGG_DRUG
106463-17-6 SECONDARY_CAS_RN
4021051 VANDF
4024076 VANDF
C0257343 UMLSCUI
CHEBI:9398 CHEBI
JGX PDB_CHEM_ID
CHEMBL836 ChEMBL_ID
CHEMBL1200914 ChEMBL_ID
D000077409 MESH_DESCRIPTOR_UI
DB00706 DRUGBANK_ID
129211 PUBCHEM_CID
488 IUPHAR_LIGAND_ID
6750 INN_ID
G3P28OML5I UNII
236495 RXNORM
171693 MMSL
20642 MMSL
5541 MMSL
d04121 MMSL
006115 NDDF
006116 NDDF
108559004 SNOMEDCT_US
108560009 SNOMEDCT_US
372509005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FLOMAX HUMAN PRESCRIPTION DRUG LABEL 1 0024-5837 CAPSULE 0.40 mg ORAL NDA 30 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0115-8211 CAPSULE 0.40 mg ORAL ANDA 26 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8055 CAPSULE 0.40 mg ORAL ANDA 27 sections
tamsulosin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2076 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-7383 CAPSULE 0.40 mg ORAL ANDA 27 sections
Dutasteride and Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 10370-280 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-280 CAPSULE 0.40 mg ORAL ANDA 18 sections
TAMSULOSIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10544-550 CAPSULE 0.40 mg ORAL ANDA 17 sections
TAMSULOSIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-298 CAPSULE 0.40 mg ORAL ANDA 17 sections
FLOMAX HUMAN PRESCRIPTION DRUG LABEL 1 16590-489 CAPSULE 0.40 mg ORAL NDA 28 sections
TAMSULOSIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 33261-839 CAPSULE 0.40 mg ORAL ANDA 17 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 33342-159 CAPSULE 0.40 mg ORAL ANDA 27 sections
TAMSULOSIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 42254-012 CAPSULE 0.40 mg ORAL ANDA 17 sections
Dutasteride and Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 42291-031 CAPSULE 0.40 mg ORAL ANDA 28 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 42291-989 CAPSULE 0.40 mg ORAL ANDA 26 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-725 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-725 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-947 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-947 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43353-663 CAPSULE 0.40 mg ORAL ANDA 19 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50090-1846 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50090-3646 CAPSULE 0.40 mg ORAL ANDA 26 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50090-4906 CAPSULE 0.40 mg ORAL ANDA 26 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50090-5553 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50090-6699 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50090-6700 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-740 CAPSULE 0.40 mg ORAL ANDA 30 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-740 CAPSULE 0.40 mg ORAL ANDA 30 sections
Tamsulosin Hydrochloride Human Prescription Drug Label 1 50436-0598 CAPSULE 0.40 mg ORAL ANDA 27 sections
Tamsulosin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51407-879 CAPSULE 0.40 mg ORAL ANDA 26 sections