tadalafil ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
inhibitors of phosphodiesterase PDE5 with vasodilator action 2553 171596-29-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zalutia
  • tadalafil
  • tardenafil
  • tildenafil
  • cialis
  • IC351
A carboline derivative and PHOSPHODIESTERASE 5 INHIBITOR that is used primarily to treat ERECTILE DYSFUNCTION; BENIGN PROSTATIC HYPERPLASIA and PRIMARY PULMONARY HYPERTENSION.
  • Molecular weight: 389.41
  • Formula: C22H19N3O4
  • CLOGP: 2.58
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 74.87
  • ALOGS: -3.19
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.73 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 16 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Nov. 21, 2003 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Dyspnoea 1805.21 15.36 3420 89458 544188 49968058
Pulmonary arterial hypertension 1674.67 15.36 794 92084 19525 50492721
Pain in jaw 1550.91 15.36 933 91945 37495 50474751
Fluid retention 1434.97 15.36 984 91894 49665 50462581
Headache 1241.57 15.36 2805 90073 503730 50008516
Dyspnoea exertional 1011.67 15.36 801 92077 50432 50461814
Drug ineffective 917.70 15.36 196 92682 819137 49693109
Right ventricular failure 825.12 15.36 455 92423 15438 50496808
Pulmonary hypertension 738.98 15.36 559 92319 32858 50479388
Hypervolaemia 703.94 15.36 488 92390 25011 50487235
Flushing 696.83 15.36 731 92147 66284 50445962
Hospitalisation 584.56 15.36 671 92207 67266 50444980
Nasal congestion 566.17 15.36 577 92301 50543 50461703
Death 551.86 15.36 1572 91306 323807 50188439
Infusion site pain 539.84 15.36 316 92562 12030 50500216
Catheter site erythema 520.64 15.36 215 92663 3747 50508499
Diarrhoea 512.22 15.36 2281 90597 586195 49926051
Transfusion 473.11 15.36 295 92583 12610 50499636
Catheter site pain 453.55 15.36 192 92686 3570 50508676
Oxygen saturation decreased 442.15 15.36 606 92272 72642 50439604
Catheter management 430.22 15.36 169 92709 2570 50509676
Device related infection 401.98 15.36 321 92557 20414 50491832
Catheter site pruritus 385.42 15.36 143 92735 1844 50510402
Vascular device infection 378.30 15.36 177 92701 4207 50508039
Oedema 336.70 15.36 521 92357 69660 50442586
Catheter site discharge 335.25 15.36 127 92751 1741 50510505
Chest pain 276.10 15.36 831 92047 176051 50336195
Syncope 273.70 15.36 592 92286 102410 50409836
Infusion site erythema 271.64 15.36 180 92698 8547 50503699
Cardiac failure 264.36 15.36 489 92389 75551 50436695
Infusion related reaction 263.91 15.36 11 92867 169546 50342700
Toxicity to various agents 261.87 15.36 39 92839 212460 50299786
Alopecia 261.76 15.36 64 92814 244983 50267263
Palpitations 261.25 15.36 552 92326 93954 50418292
Rheumatoid arthritis 259.45 15.36 33 92845 202517 50309729
Oxygen consumption increased 257.26 15.36 127 92751 3409 50508837
Lung transplant 256.00 15.36 118 92760 2707 50509539
Dizziness 253.81 15.36 1280 91598 345089 50167157
Infusion site infection 251.46 15.36 98 92780 1457 50510789
Therapy change 250.39 15.36 142 92736 5083 50507163
Contraindicated product administered 244.86 15.36 6 92872 148952 50363294
Oedema peripheral 244.44 15.36 740 92138 157221 50355025
Catheter placement 242.98 15.36 103 92775 1921 50510325
Catheter site infection 242.59 15.36 130 92748 4156 50508090
Unevaluable event 237.86 15.36 354 92524 45712 50466534
Pulmonary arterial pressure increased 236.91 15.36 118 92760 3230 50509016
Therapeutic product effect decreased 229.49 15.36 4 92874 136046 50376200
Cough 228.67 15.36 962 91916 240302 50271944
Device leakage 224.61 15.36 138 92740 5740 50506506
Treatment failure 224.50 15.36 6 92872 137631 50374615
Pneumonia 210.87 15.36 1299 91579 377102 50135144
Neutropenia 210.61 15.36 16 92862 147949 50364297
Arthropathy 208.92 15.36 23 92855 157883 50354363
Drug hypersensitivity 208.64 15.36 100 92778 250910 50261336
Catheterisation cardiac 207.74 15.36 115 92763 3925 50508321
Scleroderma 204.87 15.36 121 92757 4680 50507566
Malaise 204.27 15.36 1179 91699 334353 50177893
Drug interaction 203.84 15.36 57 92821 199564 50312682
Dermatitis contact 198.43 15.36 148 92730 8498 50503748
Nausea 189.95 15.36 2050 90828 703348 49808898
Catheter site haemorrhage 186.98 15.36 95 92783 2715 50509531
Maternal exposure during pregnancy 186.35 15.36 34 92844 159744 50352502
Glossodynia 184.95 15.36 6 92872 115563 50396683
Completed suicide 182.87 15.36 16 92862 131873 50380373
Infusion site discharge 182.46 15.36 61 92817 565 50511681
Catheter site rash 175.06 15.36 62 92816 693 50511553
Catheter site swelling 173.41 15.36 72 92806 1272 50510974
Off label use 171.18 15.36 387 92491 474039 50038207
Myalgia 166.18 15.36 554 92324 123765 50388481
Device alarm issue 164.51 15.36 70 92808 1318 50510928
Hypotension 160.81 15.36 854 92024 234615 50277631
Device infusion issue 158.91 15.36 68 92810 1299 50510947
Infusion site swelling 158.37 15.36 120 92758 7056 50505190
Central venous catheterisation 156.43 15.36 77 92801 2053 50510193
Transplant evaluation 151.13 15.36 61 92817 999 50511247
Joint swelling 149.54 15.36 138 92740 245148 50267098
Pulmonary oedema 147.05 15.36 296 92582 48642 50463604
Hypoxia 145.09 15.36 302 92576 50821 50461425
Rash 143.41 15.36 375 92503 437096 50075150
Device occlusion 140.22 15.36 104 92774 5919 50506327
Device dislocation 140.10 15.36 185 92693 21361 50490885
Product use in unapproved indication 130.04 15.36 27 92851 115792 50396454
Therapeutic product effect incomplete 129.89 15.36 10 92868 91505 50420741
Product dose omission issue 127.62 15.36 670 92208 183168 50329078
Infusion site haemorrhage 126.31 15.36 75 92803 2929 50509317
Hepatic enzyme increased 124.74 15.36 48 92830 137332 50374914
Concomitant disease aggravated 123.17 15.36 109 92769 7982 50504264
Musculoskeletal stiffness 121.55 15.36 42 92836 128439 50383807
Catheter site irritation 121.14 15.36 43 92835 484 50511762
Stomatitis 117.18 15.36 22 92856 101322 50410924
Hypersensitivity 116.44 15.36 134 92744 215027 50297219
Catheter site inflammation 113.58 15.36 44 92834 643 50511603
Pain in extremity 108.16 15.36 863 92015 272002 50240244
Hypertension 107.44 15.36 138 92740 211065 50301181
Dyspnoea at rest 105.75 15.36 72 92806 3575 50508671
Presyncope 104.03 15.36 171 92707 24027 50488219
Drug intolerance 102.59 15.36 152 92726 218952 50293294
Ascites 101.91 15.36 212 92666 35649 50476597
Systemic lupus erythematosus 100.93 15.36 67 92811 140555 50371691
Complication associated with device 98.63 15.36 128 92750 14527 50497719
Catheter site vesicles 98.24 15.36 32 92846 271 50511975
Feeling abnormal 97.30 15.36 472 92406 125020 50387226
Device connection issue 96.18 15.36 37 92841 530 50511716
Brain natriuretic peptide increased 96.15 15.36 74 92804 4453 50507793
Abdominal distension 93.89 15.36 321 92557 72582 50439664
Pericarditis 93.31 15.36 16 92862 78673 50433573
Acute kidney injury 92.16 15.36 174 92704 227884 50284362
Discomfort 91.73 15.36 42 92836 108338 50403908
Leukopenia 91.41 15.36 9 92869 67519 50444727
Epistaxis 90.75 15.36 291 92587 63663 50448583
Exposure during pregnancy 86.37 15.36 58 92820 120957 50391289
Intentional overdose 85.47 15.36 8 92870 62496 50449750
Haemoptysis 84.46 15.36 161 92717 25412 50486834
Psoriasis 84.12 15.36 13 92865 68987 50443259
Overdose 83.85 15.36 39 92839 99688 50412558
Wound 83.50 15.36 45 92833 105749 50406497
Pericardial effusion 83.16 15.36 160 92718 25429 50486817
Pulmonary veno-occlusive disease 82.98 15.36 39 92839 936 50511310
Cardiac failure congestive 82.42 15.36 340 92538 84042 50428204
Blood cholesterol increased 81.34 15.36 5 92873 55210 50457036
Confusional state 80.36 15.36 136 92742 185792 50326454
Product use issue 79.83 15.36 94 92784 149381 50362865
Device related sepsis 78.65 15.36 59 92819 3416 50508830
Disease complication 78.48 15.36 54 92824 2728 50509518
Injection site discharge 77.31 15.36 29 92849 386 50511860
Pruritus 76.94 15.36 265 92613 283303 50228943
Impaired healing 76.82 15.36 17 92861 69769 50442477
White blood cell count decreased 76.73 15.36 61 92817 116661 50395585
Heart rate increased 76.02 15.36 312 92566 76938 50435308
Paracentesis 75.99 15.36 36 92842 880 50511366
Drug abuse 75.93 15.36 10 92868 59836 50452410
Thrombocytopenia 75.17 15.36 74 92804 127599 50384647
Cardiac pacemaker insertion 71.71 15.36 57 92821 3596 50508650
Osteoarthritis 71.05 15.36 19 92859 68587 50443659
Therapy non-responder 70.42 15.36 230 92648 50792 50461454
Walking distance test abnormal 70.01 15.36 29 92849 509 50511737
Chest discomfort 69.87 15.36 346 92532 92376 50419870
C-reactive protein increased 69.62 15.36 18 92860 66456 50445790
Seizure 67.47 15.36 70 92808 117804 50394442
Suicide attempt 67.20 15.36 8 92870 51724 50460522
Liver transplant 66.40 15.36 44 92834 2088 50510158
Anaphylactic reaction 66.31 15.36 10 92868 54045 50458201
Helicobacter infection 66.29 15.36 7 92871 49695 50462551
Lower respiratory tract infection 66.10 15.36 47 92831 95154 50417092
Urticaria 65.47 15.36 85 92793 129476 50382770
Depression 65.22 15.36 128 92750 165295 50346951
Blood pressure decreased 64.94 15.36 238 92640 55671 50456575
Infusion site abscess 64.45 15.36 21 92857 178 50512068
Infusion site induration 62.45 15.36 31 92847 842 50511404
Abortion spontaneous 60.88 15.36 4 92874 41768 50470478
Multiple sclerosis relapse 60.09 15.36 5 92873 42959 50469287
Suicidal ideation 59.94 15.36 14 92864 55371 50456875
Blood pressure increased 59.72 15.36 95 92783 133037 50379209
Condition aggravated 59.47 15.36 818 92060 296240 50216006
Intentional product use issue 58.83 15.36 34 92844 76884 50435362
Electrocardiogram QT prolonged 58.41 15.36 12 92866 51874 50460372
Infusion site warmth 58.21 15.36 35 92843 1399 50510847
Oxygen therapy 57.90 15.36 38 92840 1774 50510472
Infusion site pruritus 57.86 15.36 52 92826 3885 50508361
Atrial flutter 56.58 15.36 75 92803 8688 50503558
Cardiac disorder 55.97 15.36 190 92688 42789 50469457
Muscle injury 55.77 15.36 3 92875 37108 50475138
Injection site bruising 55.17 15.36 3 92875 36765 50475481
Catheter site warmth 54.84 15.36 19 92859 198 50512048
Cognitive disorder 54.49 15.36 8 92870 44115 50468131
Cardiac failure high output 54.24 15.36 20 92858 253 50511993
Cardiac ablation 53.60 15.36 32 92846 1262 50510984
Infusion site irritation 53.19 15.36 25 92853 600 50511646
Disease progression 52.99 15.36 329 92549 95537 50416709
Respiratory failure 52.98 15.36 317 92561 90864 50421382
Dialysis 52.25 15.36 75 92803 9363 50502883
Coma 51.38 15.36 20 92858 56859 50455387
Sinus congestion 51.20 15.36 92 92786 13879 50498367
Atrial septal defect repair 50.36 15.36 18 92860 207 50512039
Intentional product misuse 50.20 15.36 12 92866 46722 50465524
Blood pressure systolic increased 49.93 15.36 4 92874 35445 50476801
Emergency care 49.18 15.36 26 92852 808 50511438
Pancytopenia 49.10 15.36 49 92829 83981 50428265
Decreased appetite 48.53 15.36 573 92305 200350 50311896
Acute respiratory failure 48.35 15.36 139 92739 28643 50483603
Seasonal allergy 47.97 15.36 92 92786 14584 50497662
Agitation 47.85 15.36 19 92859 53365 50458881
Stent placement 47.77 15.36 44 92834 3394 50508852
Blister 47.45 15.36 52 92826 85366 50426880
Mobility decreased 47.43 15.36 46 92832 79902 50432344
Pulmonary arterial pressure abnormal 47.38 15.36 21 92857 438 50511808
Injection site pain 47.21 15.36 82 92796 110942 50401304
Bradycardia 47.14 15.36 30 92848 64396 50447850
Irritable bowel syndrome 46.61 15.36 18 92860 51423 50460823
Paraesthesia 46.55 15.36 94 92784 120149 50392097
Peripheral swelling 46.13 15.36 579 92299 205357 50306889
Deep vein thrombosis 46.07 15.36 40 92838 73264 50438982
Hyponatraemia 45.61 15.36 66 92812 96073 50416173
Catheter removal 45.48 15.36 19 92859 341 50511905
Neuropathy peripheral 45.34 15.36 67 92811 96690 50415556
Cardiac operation 45.25 15.36 39 92839 2756 50509490
Injection site infection 43.70 15.36 31 92847 1645 50510601
Exercise tolerance decreased 43.29 15.36 49 92829 4825 50507421
Wrong technique in product usage process 43.22 15.36 24 92854 55486 50456760
Right ventricular dilatation 43.17 15.36 25 92853 931 50511315
Faeces soft 43.16 15.36 45 92833 4039 50508207
Injection site reaction 42.92 15.36 19 92859 50013 50462233
Aspiration pleural cavity 42.72 15.36 23 92855 742 50511504
Hypoaesthesia 42.34 15.36 108 92770 127149 50385097
Head discomfort 42.23 15.36 74 92804 10945 50501301
Productive cough 42.09 15.36 200 92678 52494 50459752
Thrombosis in device 41.87 15.36 37 92841 2704 50509542
Catheter site related reaction 41.86 15.36 23 92855 773 50511473
Dizziness postural 41.86 15.36 54 92824 6091 50506155
Angioedema 41.82 15.36 9 92869 37667 50474579
Injury 41.31 15.36 19 92859 48906 50463340
Arthralgia 39.99 15.36 566 92312 438136 50074110
Dysentery 39.78 15.36 22 92856 749 50511497
Bone marrow failure 39.23 15.36 3 92875 27621 50484625
Mineral supplementation 38.99 15.36 21 92857 678 50511568
Blood glucose increased 38.97 15.36 44 92834 71280 50440966
Dizziness exertional 38.87 15.36 17 92861 343 50511903
Nasopharyngitis 38.84 15.36 532 92346 192395 50319851
Foetal exposure during pregnancy 38.77 15.36 3 92875 27356 50484890
Hepatotoxicity 38.54 15.36 3 92875 27223 50485023
Depressed level of consciousness 38.27 15.36 24 92854 51929 50460317
Catheter site erosion 38.24 15.36 11 92867 58 50512188
Blood iron decreased 38.19 15.36 73 92805 11542 50500704
Treatment noncompliance 38.13 15.36 132 92746 30018 50482228
Device breakage 37.74 15.36 65 92813 9482 50502764
Pulmonary hypertensive crisis 37.69 15.36 14 92864 181 50512065
Influenza 37.44 15.36 287 92591 89251 50422995
Vomiting 37.14 15.36 1107 91771 459651 50052595
Internal haemorrhage 36.86 15.36 43 92835 4374 50507872
Nocturnal dyspnoea 36.65 15.36 23 92855 993 50511253
Catheter site discolouration 36.50 15.36 12 92866 105 50512141
Rehabilitation therapy 35.90 15.36 25 92853 1288 50510958
Plasma cell myeloma 35.76 15.36 7 92871 31315 50480931
Lung disorder 35.75 15.36 170 92708 44629 50467617
Osteoporosis 35.52 15.36 19 92859 44860 50467386
Paranasal sinus discomfort 35.38 15.36 35 92843 2951 50509295
Chemotherapy 34.95 15.36 25 92853 1344 50510902
Systemic scleroderma 34.95 15.36 21 92857 838 50511408
Therapeutic response decreased 34.54 15.36 22 92856 47209 50465037
Abdominal cavity drainage 34.51 15.36 16 92862 372 50511874
Catheter site scab 34.32 15.36 13 92865 178 50512068
Cardioversion 34.14 15.36 23 92855 1122 50511124
Weight decreased 34.09 15.36 583 92295 220662 50291584
General physical health deterioration 34.07 15.36 140 92738 142294 50369952
Device issue 34.07 15.36 97 92781 19875 50492371
Hallucination 33.76 15.36 22 92856 46635 50465611
Hepatocellular injury 33.72 15.36 4 92874 25943 50486303
Delirium 33.56 15.36 14 92864 38178 50474068
Inappropriate schedule of product administration 33.40 15.36 50 92828 71781 50440465
Metapneumovirus infection 33.20 15.36 20 92858 802 50511444
Lactic acidosis 33.11 15.36 10 92868 33345 50478901
Infusion site rash 33.11 15.36 24 92854 1318 50510928
Device physical property issue 33.05 15.36 26 92852 1616 50510630
Product quality issue 32.99 15.36 8 92870 30850 50481396
Metabolic acidosis 32.90 15.36 15 92863 38810 50473436
Hypoglycaemia 32.75 15.36 30 92848 53551 50458695
Catheterisation cardiac abnormal 32.20 15.36 13 92865 213 50512033
N-terminal prohormone brain natriuretic peptide increased 32.12 15.36 26 92852 1684 50510562
Extra dose administered 32.09 15.36 43 92835 5033 50507213
Blood creatine phosphokinase increased 32.05 15.36 5 92873 26362 50485884
Gastritis hypertrophic 32.01 15.36 9 92869 43 50512203
Ill-defined disorder 31.77 15.36 32 92846 54622 50457624
Fibromyalgia 31.48 15.36 22 92856 44956 50467290
Tremor 31.35 15.36 107 92771 114796 50397450
Somnolence 31.33 15.36 162 92716 154823 50357423
Pulmonary pain 30.95 15.36 29 92849 2286 50509960
Contusion 30.92 15.36 104 92774 112079 50400167
Medical device change 30.82 15.36 14 92864 310 50511936
Hypocalcaemia 30.60 15.36 6 92872 26810 50485436
Mouth ulceration 30.48 15.36 7 92871 28017 50484229
Drug titration error 30.37 15.36 17 92861 593 50511653
Infusion site pustule 30.22 15.36 8 92870 29 50512217
Hepatitis 30.21 15.36 10 92868 31443 50480803
Cor pulmonale 29.88 15.36 26 92852 1861 50510385
Hepatic cirrhosis 29.63 15.36 85 92793 17492 50494754
Throat irritation 29.62 15.36 122 92756 30117 50482129
Altered state of consciousness 29.43 15.36 3 92875 21907 50490339
Renal disorder 29.37 15.36 114 92764 27391 50484855
Diabetes mellitus 29.32 15.36 28 92850 49005 50463241
Hospice care 29.25 15.36 44 92834 5728 50506518
Platelet transfusion 28.69 15.36 17 92861 661 50511585
Blood potassium decreased 28.61 15.36 139 92739 36806 50475440
Agranulocytosis 28.60 15.36 3 92875 21418 50490828
Atrial fibrillation 28.56 15.36 299 92579 101446 50410800
Upper respiratory tract congestion 28.56 15.36 25 92853 1804 50510442
Cholestasis 28.33 15.36 6 92872 25395 50486851
Ear discomfort 28.09 15.36 47 92831 6697 50505549
Concomitant disease progression 28.08 15.36 26 92852 2019 50510227
Right ventricular dysfunction 27.69 15.36 23 92855 1545 50510701
Left ventricular failure 27.58 15.36 39 92839 4802 50507444
Medication error 27.54 15.36 16 92862 36088 50476158
Migraine 27.50 15.36 234 92644 75046 50437200
Oral herpes 27.42 15.36 3 92875 20722 50491524
Infusion site discolouration 27.39 15.36 16 92862 606 50511640
Oxygen saturation abnormal 27.18 15.36 29 92849 2673 50509573
Sinus disorder 27.08 15.36 85 92793 18373 50493873
Orthopnoea 26.91 15.36 42 92836 5647 50506599
Transplant 26.73 15.36 16 92862 634 50511612
Stevens-Johnson syndrome 26.73 15.36 4 92874 21748 50490498
Ear congestion 26.60 15.36 25 92853 1978 50510268
Mechanical ventilation 26.54 15.36 20 92858 1166 50511080
Cardiac output increased 26.53 15.36 10 92868 135 50512111
Dyspepsia 26.38 15.36 229 92649 73868 50438378
Purulent discharge 26.32 15.36 36 92842 4296 50507950
Intentional dose omission 26.31 15.36 39 92839 5011 50507235
Inflammation 26.08 15.36 40 92838 56872 50455374
Emotional distress 26.01 15.36 10 92868 28653 50483593
Drug ineffective for unapproved indication 25.95 15.36 4 92874 21277 50490969
Asthma 25.88 15.36 81 92797 89256 50422990
Arthritis 25.57 15.36 78 92800 86643 50425603
Pulmonary arterial wedge pressure increased 25.53 15.36 12 92866 288 50511958
Heart valve replacement 25.47 15.36 14 92864 471 50511775
Dysarthria 25.25 15.36 19 92859 37384 50474862
Anaemia 25.24 15.36 624 92254 251832 50260414
Hyperglycaemia 25.22 15.36 18 92860 36387 50475859
Infusion site vesicles 25.16 15.36 13 92865 385 50511861
Basal cell carcinoma 25.08 15.36 6 92872 23350 50488896
Hypercalcaemia 25.07 15.36 6 92872 23346 50488900
Cardiac flutter 25.01 15.36 31 92847 3359 50508887
Loss of consciousness 24.88 15.36 297 92581 104056 50408190
Hepatic steatosis 24.77 15.36 7 92871 24377 50487869
Psychotic disorder 24.64 15.36 5 92873 21807 50490439
Infusion site cellulitis 24.17 15.36 10 92868 175 50512071
No adverse event 24.06 15.36 16 92862 33562 50478684
Application site pruritus 24.00 15.36 32 92846 3727 50508519
Incorrect route of product administration 23.96 15.36 3 92875 18663 50493583
Hypokalaemia 23.95 15.36 82 92796 87910 50424336
Infusion site inflammation 23.87 15.36 11 92867 252 50511994
Pulmonary artery aneurysm 23.86 15.36 7 92871 40 50512206
Hyperkalaemia 23.81 15.36 32 92846 48057 50464189
Osteonecrosis 23.76 15.36 6 92872 22511 50489735
Ejection fraction decreased 23.71 15.36 3 92875 18517 50493729
Right-to-left cardiac shunt 23.71 15.36 10 92868 184 50512062
Terminal state 23.65 15.36 24 92854 2086 50510160
Disturbance in attention 23.53 15.36 14 92864 31172 50481074
Aggression 23.52 15.36 5 92873 21111 50491135
Central venous catheter removal 23.45 15.36 12 92866 348 50511898
Iron deficiency anaemia 23.32 15.36 76 92802 16758 50495488
Dyskinesia 23.24 15.36 11 92867 27850 50484396
Skin lesion 23.16 15.36 10 92868 26717 50485529
Bursitis 23.16 15.36 6 92872 22129 50490117
Pleural effusion 23.15 15.36 240 92638 81214 50431032
Application site hypersensitivity 23.04 15.36 10 92868 198 50512048
Cholecystectomy 22.99 15.36 52 92826 9251 50502995
Clostridium difficile infection 22.87 15.36 100 92778 25339 50486907
Gout 22.86 15.36 59 92819 11411 50500835
Swollen tongue 22.83 15.36 12 92866 28618 50483628
Skin exfoliation 22.79 15.36 17 92861 33595 50478651
Therapy cessation 22.44 15.36 101 92777 25910 50486336
Joint stiffness 22.32 15.36 14 92864 30294 50481952
Polypectomy 22.32 15.36 14 92864 604 50511642
Acute myocardial infarction 22.29 15.36 13 92865 29260 50482986
Withdrawal syndrome 22.16 15.36 3 92875 17587 50494659
Pancreatitis acute 22.13 15.36 8 92870 23804 50488442
Catheter site induration 22.06 15.36 7 92871 54 50512192
Vascular cauterisation 21.95 15.36 7 92871 55 50512191
Drug eruption 21.82 15.36 8 92870 23598 50488648
Catheter site dermatitis 21.73 15.36 7 92871 57 50512189
Haematuria 21.54 15.36 10 92868 25603 50486643
Endotracheal intubation 21.46 15.36 23 92855 2131 50510115
Abdominal pain upper 21.41 15.36 411 92467 158898 50353348
Rhinorrhoea 21.36 15.36 165 92713 51418 50460828
Osteopenia 21.21 15.36 3 92875 17015 50495231
Hypomagnesaemia 21.15 15.36 8 92870 23148 50489098
Infusion site oedema 21.08 15.36 13 92865 544 50511702
Infusion site reaction 21.00 15.36 23 92855 2183 50510063
Gastroenteritis viral 20.99 15.36 79 92799 18707 50493539
Primary biliary cholangitis 20.81 15.36 17 92861 1115 50511131
Pulmonary embolism 20.72 15.36 106 92772 101598 50410648
First bite syndrome 20.72 15.36 5 92873 11 50512235
Echocardiogram abnormal 20.64 15.36 17 92861 1128 50511118
Metastases to bone 20.59 15.36 4 92874 17991 50494255
Respiratory syncytial virus infection 20.51 15.36 35 92843 5067 50507179
Respiratory tract congestion 20.48 15.36 65 92813 14134 50498112
Epilepsy 20.46 15.36 7 92871 21560 50490686
Diet noncompliance 20.40 15.36 10 92868 264 50511982
Catheter site extravasation 20.33 15.36 10 92868 266 50511980
Catheter culture positive 20.28 15.36 8 92870 123 50512123
Wrong dose 20.25 15.36 15 92863 852 50511394
Intracardiac pressure increased 19.93 15.36 6 92872 38 50512208
Pneumonitis 19.91 15.36 15 92863 29495 50482751
Hot flush 19.82 15.36 144 92734 44025 50468221
Bone disorder 19.78 15.36 5 92873 18747 50493499
Laboratory test abnormal 19.61 15.36 9 92869 23199 50489047
Bendopnoea 19.61 15.36 5 92873 15 50512231
Generalised tonic-clonic seizure 19.59 15.36 12 92866 26298 50485948
Right ventricular systolic pressure increased 19.51 15.36 12 92866 500 50511746
Ischaemic stroke 19.44 15.36 3 92875 15945 50496301
Pericardial drainage 19.34 15.36 9 92869 211 50512035
Encephalopathy 19.29 15.36 20 92858 33691 50478555
Drug withdrawal syndrome 19.29 15.36 11 92867 25070 50487176
Loss of personal independence in daily activities 19.25 15.36 65 92813 69985 50442261
Disseminated intravascular coagulation 19.20 15.36 4 92874 17131 50495115
Localised oedema 19.06 15.36 33 92845 4834 50507412
Adverse drug reaction 19.03 15.36 46 92832 55176 50457070
Injection site mass 19.00 15.36 3 92875 15677 50496569
Injection site erythema 18.96 15.36 72 92806 74864 50437382
Obstructive airways disorder 18.95 15.36 3 92875 15649 50496597
Middle ear effusion 18.93 15.36 21 92857 2022 50510224
Infusion site dermatitis 18.92 15.36 5 92873 18 50512228
Lymphopenia 18.90 15.36 3 92875 15618 50496628
N-terminal prohormone brain natriuretic peptide 18.83 15.36 6 92872 47 50512199
Oropharyngeal pain 18.79 15.36 222 92656 77579 50434667
Colitis 18.71 15.36 26 92852 38503 50473743
Catheter site mass 18.70 15.36 5 92873 19 50512227
Cardiac resynchronisation therapy 18.70 15.36 5 92873 19 50512227
Muscle twitching 18.59 15.36 3 92875 15428 50496818
Viral infection 18.53 15.36 106 92772 29880 50482366
Tracheostomy 18.52 15.36 12 92866 548 50511698
Acute right ventricular failure 18.45 15.36 8 92870 158 50512088
Gastric varices 18.45 15.36 8 92870 158 50512088
Haemoglobin decreased 18.41 15.36 332 92546 126884 50385362
Multiple allergies 18.41 15.36 45 92833 8418 50503828
Full blood count decreased 18.37 15.36 9 92869 22337 50489909
Metastases to liver 18.27 15.36 7 92871 20097 50492149
Disorientation 18.20 15.36 23 92855 35461 50476785
Alanine aminotransferase increased 18.05 15.36 92 92786 88267 50423979
Product administration interrupted 17.97 15.36 15 92863 1014 50511232
Injection site pruritus 17.95 15.36 29 92849 40382 50471864
Product prescribing error 17.91 15.36 8 92870 20953 50491293
Pulmonary artery dilatation 17.91 15.36 9 92869 251 50511995
CREST syndrome 17.82 15.36 11 92867 461 50511785
Hyperlipidaemia 17.81 15.36 5 92873 17485 50494761
Eosinophilia 17.79 15.36 6 92872 18646 50493600
Abnormal behaviour 17.61 15.36 7 92871 19651 50492595
Immunodeficiency 17.60 15.36 3 92875 14825 50497421
Liver injury 17.53 15.36 12 92866 24794 50487452
Femur fracture 17.48 15.36 26 92852 37438 50474808
Premature delivery 17.33 15.36 11 92867 23652 50488594
Blood carbon monoxide increased 17.18 15.36 4 92874 7 50512239
Prophylaxis 17.18 15.36 4 92874 7 50512239
Pregnancy test positive 17.16 15.36 7 92871 118 50512128
Catheter site urticaria 17.13 15.36 5 92873 28 50512218
Cardio-respiratory arrest 16.95 15.36 47 92831 53845 50458401
Pulmonary congestion 16.94 15.36 64 92814 15183 50497063
Female sterilisation 16.92 15.36 11 92867 505 50511741
Urinary retention 16.80 15.36 14 92864 26176 50486070
Infusion site nodule 16.79 15.36 15 92863 1112 50511134
Transaminases increased 16.51 15.36 16 92862 27808 50484438
Accidental exposure to product 16.50 15.36 11 92867 23046 50489200
Chronic obstructive pulmonary disease 16.41 15.36 160 92718 53275 50458971
Orthostatic hypotension 16.30 15.36 18 92860 29463 50482783
Vasculitis 16.24 15.36 3 92875 13988 50498258
Head injury 16.24 15.36 87 92791 23933 50488313
Blood calcium decreased 16.04 15.36 9 92869 20697 50491549
Herpes zoster 16.04 15.36 71 92807 70715 50441531
Injection site erosion 15.99 15.36 6 92872 80 50512166
Scleroderma associated digital ulcer 15.94 15.36 4 92874 11 50512235
Joint range of motion decreased 15.92 15.36 7 92871 18505 50493741
Cor pulmonale acute 15.89 15.36 9 92869 321 50511925
Cerebral infarction 15.88 15.36 10 92868 21594 50490652
Musculoskeletal disorder 15.83 15.36 6 92872 17343 50494903
Hypothyroidism 15.62 15.36 24 92854 34101 50478145
Device malfunction 15.60 15.36 62 92816 15059 50497187
Bronchitis 15.48 15.36 273 92605 103886 50408360
Cardiac output decreased 15.47 15.36 13 92865 887 50511359
Haemorrhage 15.43 15.36 158 92720 53283 50458963
Therapeutic response unexpected 15.39 15.36 5 92873 15910 50496336
Intervertebral disc degeneration 15.38 15.36 3 92875 13458 50498788

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Headache 633.47 12.29 1030 44384 172977 29356136
Pulmonary arterial hypertension 542.47 12.29 253 45161 7196 29521917
Fluid retention 456.72 12.29 339 45075 23221 29505892
Pain in jaw 433.27 12.29 252 45162 11389 29517724
Dyspnoea 373.35 12.29 1222 44192 325510 29203603
Right ventricular failure 337.20 12.29 187 45227 7703 29521410
Pulmonary hypertension 258.03 12.29 220 45194 18388 29510725
Flushing 250.98 12.29 264 45150 28728 29500385
Hypervolaemia 190.98 12.29 181 45233 17364 29511749
Nasal congestion 177.92 12.29 180 45234 18699 29510414
Dyspnoea exertional 172.88 12.29 245 45169 36245 29492868
Infusion site pain 166.57 12.29 84 45330 2841 29526272
Vision blurred 144.01 12.29 237 45177 39939 29489174
Lung transplant 141.42 12.29 64 45350 1692 29527421
Oedema 137.34 12.29 233 45181 40250 29488863
Myalgia 130.60 12.29 325 45089 73694 29455419
Back pain 117.83 12.29 385 45029 101899 29427214
Catheterisation cardiac 117.26 12.29 60 45354 2093 29527020
Transfusion 117.20 12.29 94 45320 7204 29521909
Death 116.42 12.29 909 44505 341175 29187938
Optic ischaemic neuropathy 114.64 12.29 57 45357 1869 29527244
Pain in extremity 114.29 12.29 401 45013 110032 29419081
Febrile neutropenia 111.72 12.29 19 45395 112221 29416892
Cyanopsia 109.43 12.29 29 45385 132 29528981
Hospitalisation 108.95 12.29 227 45187 45761 29483352
Oxygen saturation decreased 105.50 12.29 221 45193 44716 29484397
Catheter management 105.41 12.29 42 45372 802 29528311
Catheter site erythema 103.46 12.29 46 45368 1165 29527948
Toxicity to various agents 99.51 12.29 73 45341 173588 29355525
Infusion site infection 85.99 12.29 30 45384 388 29528725
Diarrhoea 85.30 12.29 831 44583 331867 29197246
Acute kidney injury 83.40 12.29 177 45237 265090 29264023
Concomitant disease aggravated 81.81 12.29 65 45349 4913 29524200
Device related infection 76.98 12.29 107 45307 15529 29513584
Feeling abnormal 74.74 12.29 218 45196 54227 29474886
Thrombocytopenia 71.73 12.29 61 45353 134762 29394351
Transplant evaluation 70.70 12.29 27 45387 458 29528655
Infusion site erythema 69.86 12.29 39 45375 1625 29527488
Dizziness 69.76 12.29 514 44900 189170 29339943
Peripheral swelling 68.92 12.29 235 45179 63504 29465609
Therapy change 68.04 12.29 45 45369 2553 29526560
Brain natriuretic peptide increased 66.89 12.29 54 45360 4176 29524937
Product use in unapproved indication 65.01 12.29 26 45388 86849 29442264
Neutropenia 64.82 12.29 64 45350 131647 29397466
Oxygen consumption increased 64.72 12.29 34 45380 1253 29527860
Malignant neoplasm progression 62.38 12.29 18 45396 73841 29455272
Drug interaction 60.04 12.29 134 45280 197251 29331862
Priapism 60.00 12.29 52 45362 4436 29524677
Erection increased 59.30 12.29 24 45390 478 29528635
Syncope 58.64 12.29 264 45150 81107 29448006
Catheter site discharge 56.68 12.29 24 45390 538 29528575
Pulmonary arterial pressure increased 55.50 12.29 29 45385 1057 29528056
Catheter site pain 53.61 12.29 29 45385 1135 29527978
Leukopenia 53.46 12.29 10 45404 55193 29473920
Rhabdomyolysis 52.88 12.29 14 45400 60794 29468319
Visual impairment 51.84 12.29 130 45284 29578 29499535
Milk-alkali syndrome 51.68 12.29 22 45392 500 29528613
Vascular device infection 50.62 12.29 37 45377 2468 29526645
Infusion related reaction 46.92 12.29 6 45408 43880 29485233
Drug abuse 45.13 12.29 34 45380 79849 29449264
Cough 45.12 12.29 341 45073 126386 29402727
Catheter site pruritus 44.21 12.29 17 45397 294 29528819
Unevaluable event 43.33 12.29 122 45292 29729 29499384
Device alarm issue 43.06 12.29 20 45394 562 29528551
Pancytopenia 42.54 12.29 39 45375 83129 29445984
Deafness unilateral 41.32 12.29 29 45385 1814 29527299
Malaise 41.30 12.29 400 45014 159202 29369911
Palpitations 40.42 12.29 126 45288 32478 29496635
Dyspepsia 39.76 12.29 119 45295 30006 29499107
Suspected counterfeit product 39.46 12.29 15 45399 251 29528862
Fractional exhaled nitric oxide increased 37.73 12.29 16 45398 360 29528753
Mucosal inflammation 37.19 12.29 3 45411 31592 29497521
Catheter placement 36.91 12.29 19 45395 671 29528442
Right ventricular dysfunction 36.41 12.29 21 45393 932 29528181
Injection site discharge 36.03 12.29 11 45403 90 29529023
Hyponatraemia 35.44 12.29 31 45383 67602 29461511
Device dislocation 35.22 12.29 39 45375 4488 29524625
Pulmonary veno-occlusive disease 34.97 12.29 16 45398 434 29528679
Septic shock 34.85 12.29 27 45387 62533 29466580
Dermatitis contact 34.71 12.29 32 45382 2960 29526153
Confusional state 33.98 12.29 93 45321 127784 29401329
Cardiac pacemaker insertion 33.70 12.29 29 45385 2450 29526663
Faeces soft 33.04 12.29 29 45385 2516 29526597
Sinus congestion 32.93 12.29 38 45376 4574 29524539
Haematospermia 32.69 12.29 14 45400 323 29528790
Cardiac operation 32.16 12.29 29 45385 2607 29526506
Fracture of penis 31.67 12.29 12 45402 199 29528914
Depressed level of consciousness 31.18 12.29 9 45405 36933 29492180
Accommodation disorder 31.08 12.29 12 45402 210 29528903
Neutrophil count decreased 31.03 12.29 14 45400 43553 29485560
Device occlusion 30.05 12.29 40 45374 5568 29523545
Oedema peripheral 30.00 12.29 266 45148 103291 29425822
Cardiac disorder 29.95 12.29 125 45289 37138 29491975
Heart and lung transplant 29.66 12.29 9 45405 72 29529041
Catheter site rash 29.11 12.29 11 45403 181 29528932
Catheter removal 29.11 12.29 11 45403 181 29528932
Blindness unilateral 28.48 12.29 32 45382 3742 29525371
Catheter site infection 28.09 12.29 24 45390 2008 29527105
Nasopharyngitis 28.02 12.29 172 45242 59493 29469620
Catheter site haemorrhage 27.92 12.29 24 45390 2024 29527089
Treatment failure 27.70 12.29 11 45403 36928 29492185
Central venous catheterisation 27.26 12.29 18 45396 1018 29528095
Drug reaction with eosinophilia and systemic symptoms 27.24 12.29 5 45409 27987 29501126
Infusion site discharge 27.19 12.29 9 45405 98 29529015
Hypoxia 27.12 12.29 144 45270 47235 29481878
Visual acuity reduced 26.89 12.29 66 45348 14810 29514303
Infusion site warmth 26.87 12.29 9 45405 102 29529011
Hyperkalaemia 26.67 12.29 33 45381 61359 29467754
Walking distance test abnormal 26.55 12.29 10 45404 163 29528950
Bone marrow failure 26.51 12.29 5 45409 27444 29501669
General physical health deterioration 26.42 12.29 76 45338 102781 29426332
Lactic acidosis 26.22 12.29 7 45407 30240 29498873
Abdominal discomfort 25.67 12.29 143 45271 47760 29481353
Colour blindness acquired 25.24 12.29 8 45406 75 29529038
Fatigue 25.13 12.29 650 44764 316171 29212942
Product dose omission issue 25.09 12.29 242 45172 96141 29432972
Stomatitis 24.80 12.29 13 45401 37100 29492013
Chromatopsia 24.71 12.29 10 45404 199 29528914
Spontaneous penile erection 24.67 12.29 10 45404 200 29528913
Blindness 24.62 12.29 56 45358 11967 29517146
Injection site infection 24.55 12.29 16 45398 885 29528228
Seizure 24.51 12.29 68 45346 93055 29436058
Sensation of foreign body 24.45 12.29 21 45393 1769 29527344
Ejaculation failure 24.35 12.29 15 45399 752 29528361
Multiple organ dysfunction syndrome 24.33 12.29 37 45377 63079 29466034
Infusion site oedema 24.22 12.29 9 45405 141 29528972
Bradycardia 23.86 12.29 40 45374 65589 29463524
Plantar fasciitis 23.82 12.29 18 45396 1263 29527850
Medical device change 23.70 12.29 8 45406 93 29529020
Rash 23.43 12.29 183 45231 189636 29339477
Migraine 23.38 12.29 56 45358 12374 29516739
Chest pain 22.99 12.29 268 45146 111705 29417408
Haematopoietic stem cell mobilisation 22.97 12.29 9 45405 164 29528949
Tinnitus 22.83 12.29 64 45350 15550 29513563
Infusion site haemorrhage 22.65 12.29 14 45400 706 29528407
Metabolic acidosis 22.61 12.29 15 45399 37647 29491466
Visual brightness 22.35 12.29 6 45408 29 29529084
Overdose 21.98 12.29 57 45357 79762 29449351
Infusion site swelling 21.69 12.29 20 45394 1850 29527263
Liver transplant 21.65 12.29 22 45392 2294 29526819
Hallucination 21.64 12.29 22 45392 44690 29484423
Visual field defect 21.51 12.29 29 45385 4087 29525026
Pulmonary arterial pressure abnormal 21.45 12.29 9 45405 197 29528916
Sepsis 21.33 12.29 130 45284 142552 29386561
Suicide attempt 21.28 12.29 13 45401 34097 29495016
Blindness transient 21.24 12.29 20 45394 1900 29527213
Gastrooesophageal reflux disease 21.03 12.29 100 45314 31396 29497717
Erectile dysfunction 20.85 12.29 68 45346 17941 29511172
Agitation 20.83 12.29 29 45385 51275 29477838
Completed suicide 20.83 12.29 70 45344 90176 29438937
Therapeutic product effect incomplete 20.60 12.29 18 45396 39287 29489826
Cardiac failure 20.59 12.29 199 45215 79088 29450025
Rheumatoid arthritis 20.41 12.29 12 45402 32140 29496973
Drug hypersensitivity 20.28 12.29 47 45367 68359 29460754
Product substitution issue 20.22 12.29 44 45370 9128 29519985
Cardiac ablation 20.20 12.29 13 45401 704 29528409
Oxygen therapy 20.18 12.29 13 45401 705 29528408
Hyperglycaemia 20.12 12.29 14 45400 34273 29494840
Abdominal distension 20.09 12.29 130 45284 45781 29483332
Retinal detachment 20.03 12.29 30 45384 4656 29524457
Device infusion issue 19.51 12.29 12 45402 600 29528513
Counterfeit product administered 19.46 12.29 8 45406 166 29528947
Swelling 19.35 12.29 106 45308 35177 29493936
Throat irritation 19.20 12.29 42 45372 8743 29520370
Drug level increased 19.07 12.29 3 45411 18784 29510329
Pyrexia 19.04 12.29 319 45095 287303 29241810
Blood pressure decreased 18.83 12.29 127 45287 45350 29483763
Hypokalaemia 18.80 12.29 30 45384 50173 29478940
Deafness 18.59 12.29 45 45369 10010 29519103
Delirium 18.38 12.29 20 45394 39377 29489736
Blood testosterone decreased 18.01 12.29 26 45388 3904 29525209
Macular degeneration 18.00 12.29 18 45396 1842 29527271
Gout 17.94 12.29 62 45352 16849 29512264
Catheter site inflammation 17.87 12.29 8 45406 206 29528907
Aggression 17.76 12.29 17 45397 35524 29493589
Product counterfeit 17.55 12.29 7 45407 134 29528979
Hypocalcaemia 17.50 12.29 5 45409 20660 29508453
Platelet count decreased 17.45 12.29 92 45322 104580 29424533
Viral infection 17.22 12.29 56 45358 14754 29514359
Muscle spasms 17.22 12.29 164 45250 64918 29464195
Penis disorder 17.11 12.29 14 45400 1103 29528010
C-reactive protein increased 17.00 12.29 26 45388 44237 29484876
Ocular vascular disorder 17.00 12.29 7 45407 146 29528967
Off label use 16.98 12.29 343 45071 300457 29228656
Secretion discharge 16.65 12.29 26 45388 4184 29524929
Pulmonary haemosiderosis 16.65 12.29 4 45410 11 29529102
Anaphylactic reaction 16.53 12.29 11 45403 27562 29501551
White blood cell count increased 16.47 12.29 20 45394 37496 29491617
White blood cell count decreased 16.41 12.29 69 45345 83293 29445820
Heart rate increased 16.27 12.29 109 45305 38829 29490284
Disorientation 16.10 12.29 13 45401 29502 29499611
Cardioversion 16.07 12.29 12 45402 827 29528286
Cardiac output increased 16.06 12.29 5 45409 44 29529069
Loss of consciousness 15.97 12.29 179 45235 73877 29455236
Condition aggravated 15.88 12.29 314 45100 145981 29383132
Nausea 15.77 12.29 567 44847 288688 29240425
Pneumonitis 15.74 12.29 12 45402 28032 29501081
Paracentesis 15.65 12.29 9 45405 397 29528716
Haemoptysis 15.57 12.29 90 45324 30460 29498653
Acute respiratory distress syndrome 15.37 12.29 8 45406 22927 29506186
Device breakage 15.36 12.29 16 45398 1718 29527395
Lower respiratory tract infection 15.32 12.29 11 45403 26491 29502622
Drug resistance 15.21 12.29 7 45407 21533 29507580
Blood creatinine increased 15.21 12.29 73 45341 85029 29444084
Retinal vein occlusion 15.20 12.29 15 45399 1510 29527603
Complication associated with device 15.15 12.29 28 45386 5163 29523950
Dialysis 15.08 12.29 42 45372 10166 29518947
Therapy non-responder 15.07 12.29 90 45324 30821 29498292
Drug titration error 15.04 12.29 9 45405 428 29528685
Catheter site irritation 15.04 12.29 6 45408 115 29528998
Biliary catheter insertion 14.98 12.29 5 45409 56 29529057
Mitral perforation 14.95 12.29 4 45410 19 29529094
Scleroderma 14.92 12.29 14 45400 1324 29527789
Cancer surgery 14.91 12.29 9 45405 435 29528678
Chest discomfort 14.81 12.29 121 45293 45862 29483251
Dizziness exertional 14.62 12.29 6 45408 124 29528989
Presyncope 14.54 12.29 56 45358 16033 29513080
Creatinine renal clearance abnormal 14.53 12.29 7 45407 214 29528899
Hypoglycaemia 14.50 12.29 33 45381 48313 29480800
Chorioretinopathy 14.25 12.29 14 45400 1402 29527711
Abdominal cavity drainage 14.25 12.29 8 45406 337 29528776
Hepatic function abnormal 14.20 12.29 24 45390 39235 29489878
Weight increased 14.20 12.29 180 45234 76487 29452626
Surgery 14.11 12.29 45 45369 11734 29517379
Sleep apnoea syndrome 14.10 12.29 59 45355 17540 29511573
Scrotal haematocoele 14.04 12.29 4 45410 25 29529088
Acute myeloid leukaemia 13.98 12.29 4 45410 16509 29512604
Blood lactate dehydrogenase increased 13.95 12.29 6 45408 19203 29509910
Metabolic alkalosis 13.91 12.29 13 45401 1223 29527890
Colour blindness 13.87 12.29 7 45407 237 29528876
Myelodysplastic syndrome 13.84 12.29 5 45409 17789 29511324
Psychotic disorder 13.79 12.29 7 45407 20347 29508766
Gastrointestinal cancer metastatic 13.72 12.29 5 45409 74 29529039
Tubulointerstitial nephritis 13.65 12.29 5 45409 17638 29511475
Diuretic therapy 13.65 12.29 4 45410 28 29529085
Acute respiratory failure 13.60 12.29 78 45336 26324 29502789
Intentional product use issue 13.58 12.29 28 45386 42470 29486643
Neutrophil count increased 13.58 12.29 3 45411 14739 29514374
Pulmonary oedema 13.52 12.29 112 45302 42623 29486490
Myoglobin blood increased 13.51 12.29 16 45398 1979 29527134
Coma 13.47 12.29 25 45389 39425 29489688
Emergency care 13.45 12.29 7 45407 253 29528860
Diagnostic procedure 13.41 12.29 4 45410 30 29529083
Hepatocellular injury 13.38 12.29 8 45406 21235 29507878
Disease recurrence 13.20 12.29 4 45410 15910 29513203
Immunoglobulin therapy 13.16 12.29 3 45411 6 29529107
Systolic hypertension 13.13 12.29 7 45407 266 29528847
Feeding tube user 13.07 12.29 4 45410 33 29529080
Terminal state 13.02 12.29 21 45393 3473 29525640
Catheter site extravasation 12.97 12.29 5 45409 87 29529026
Urethral haemorrhage 12.97 12.29 8 45406 402 29528711
Pulmonary arterial wedge pressure increased 12.67 12.29 5 45409 93 29529020
Neuropathy peripheral 12.65 12.29 61 45353 70966 29458147
Right ventricular dilatation 12.57 12.29 9 45405 581 29528532
Infusion site cellulitis 12.57 12.29 5 45409 95 29529018
Pericardial effusion 12.50 12.29 65 45349 21143 29507970
Catheter site swelling 12.44 12.29 7 45407 296 29528817
Influenza like illness 12.41 12.29 72 45342 24398 29504715
Chloropsia 12.30 12.29 3 45411 9 29529104

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary arterial hypertension 1886.33 12.54 927 118719 24440 64354646
Dyspnoea 1833.02 12.54 4066 115580 714608 63664478
Pain in jaw 1781.66 12.54 1046 118600 39709 64339377
Fluid retention 1700.70 12.54 1168 118478 58438 64320648
Headache 1607.95 12.54 3221 116425 526246 63852840
Right ventricular failure 1011.86 12.54 579 119067 20892 64358194
Dyspnoea exertional 919.81 12.54 892 118754 72838 64306248
Pulmonary hypertension 839.47 12.54 672 118974 42467 64336619
Hypervolaemia 791.34 12.54 618 119028 37667 64341419
Flushing 773.09 12.54 837 118809 77811 64301275
Death 698.52 12.54 2220 117426 480485 63898601
Nasal congestion 634.09 12.54 662 118984 58996 64320090
Infusion site pain 556.70 12.54 305 119341 10092 64368994
Catheter site erythema 550.81 12.54 238 119408 4611 64374475
Transfusion 541.91 12.54 365 119281 17629 64361457
Drug ineffective 536.28 12.54 465 119181 839782 63539304
Diarrhoea 500.90 12.54 2646 117000 720058 63659028
Catheter management 465.91 12.54 190 119456 3165 64375921
Hospitalisation 449.75 12.54 623 119023 74584 64304502
Oxygen saturation decreased 447.20 12.54 751 118895 106425 64272661
Catheter site pain 445.40 12.54 200 119446 4262 64374824
Oedema 441.90 12.54 687 118959 91248 64287838
Device related infection 428.25 12.54 395 119251 30231 64348855
Toxicity to various agents 375.41 12.54 105 119541 363408 64015678
Catheter site pruritus 355.25 12.54 138 119508 2010 64377076
Catheter site discharge 346.07 12.54 137 119509 2104 64376982
Lung transplant 340.92 12.54 162 119484 3946 64375140
Vascular device infection 319.02 12.54 177 119469 6003 64373083
Catheterisation cardiac 297.46 12.54 156 119490 4717 64374369
Drug interaction 278.94 12.54 163 119483 361920 64017166
Dizziness 276.80 12.54 1546 118100 428617 63950469
Febrile neutropenia 271.42 12.54 20 119626 187637 64191449
Oxygen consumption increased 266.45 12.54 142 119504 4439 64374647
Infusion site infection 263.04 12.54 102 119544 1478 64377608
Infusion site erythema 262.66 12.54 162 119484 6711 64372375
Unevaluable event 261.79 12.54 391 119255 50098 64328988
Syncope 257.33 12.54 758 118888 156877 64222209
Catheter placement 254.90 12.54 115 119531 2478 64376608
Neutropenia 253.22 12.54 66 119580 239558 64139528
Infusion related reaction 248.30 12.54 14 119632 164453 64214633
Pulmonary arterial pressure increased 246.22 12.54 130 119516 3986 64375100
Palpitations 242.52 12.54 573 119073 103915 64275171
Myalgia 242.19 12.54 745 118901 157872 64221214
Oedema peripheral 241.02 12.54 897 118749 209420 64169666
Catheter site infection 240.25 12.54 143 119503 5550 64373536
Chest pain 234.36 12.54 962 118684 235018 64144068
Therapy change 219.17 12.54 141 119505 6293 64372793
Acute kidney injury 206.26 12.54 322 119324 448918 63930168
Cough 206.12 12.54 1104 118542 301044 64078042
Malaise 205.51 12.54 1347 118299 394900 63984186
Cardiac failure 201.32 12.54 621 119025 131752 64247334
Concomitant disease aggravated 199.59 12.54 168 119478 11374 64367712
Device leakage 198.43 12.54 146 119500 8120 64370966
Completed suicide 196.71 12.54 85 119561 224329 64154757
Rheumatoid arthritis 194.33 12.54 35 119611 164259 64214827
Transplant evaluation 191.95 12.54 81 119565 1476 64377610
Product dose omission issue 188.59 12.54 788 118858 193959 64185127
Product use in unapproved indication 187.76 12.54 48 119598 176570 64202516
Device alarm issue 186.35 12.54 84 119562 1806 64377280
Scleroderma 185.22 12.54 114 119532 4704 64374382
Catheter site rash 181.42 12.54 68 119578 893 64378193
Nausea 177.45 12.54 2228 117418 783572 63595514
Pain in extremity 175.44 12.54 1060 118586 302025 64077061
Off label use 175.29 12.54 596 119050 632210 63746876
Catheter site haemorrhage 172.36 12.54 107 119539 4484 64374602
Central venous catheterisation 170.87 12.54 89 119557 2652 64376434
Synovitis 160.93 12.54 5 119641 99085 64280001
Malignant neoplasm progression 160.41 12.54 13 119633 112858 64266228
Contraindicated product administered 160.22 12.54 10 119636 107819 64271267
Drug hypersensitivity 160.20 12.54 124 119522 237691 64141395
Dermatitis contact 159.76 12.54 133 119513 8867 64370219
Treatment failure 159.17 12.54 16 119630 116800 64262286
Device dislocation 152.02 12.54 192 119454 20986 64358100
Infusion site swelling 150.63 12.54 105 119541 5360 64373726
Thrombocytopenia 147.83 12.54 119 119527 223682 64155404
Catheter site swelling 146.73 12.54 68 119578 1562 64377524
Therapeutic product effect decreased 144.39 12.54 21 119625 115330 64263756
Feeling abnormal 139.06 12.54 553 119093 133049 64246037
Device occlusion 138.80 12.54 128 119518 9785 64369301
Leukopenia 137.58 12.54 14 119632 101228 64277858
Arthropathy 134.19 12.54 30 119616 120937 64258149
Alopecia 132.55 12.54 71 119575 165619 64213467
Infusion site haemorrhage 132.50 12.54 71 119575 2244 64376842
Hypoxia 130.66 12.54 410 119236 87739 64291347
Drug abuse 127.81 12.54 43 119603 132331 64246755
Infusion site discharge 125.48 12.54 45 119601 517 64378569
Therapeutic product effect incomplete 124.62 12.54 21 119625 103461 64275625
Pneumonia 123.88 12.54 1582 118064 557994 63821092
Rhabdomyolysis 121.29 12.54 14 119632 91712 64287374
Brain natriuretic peptide increased 119.57 12.54 105 119541 7528 64371558
Catheter site inflammation 119.30 12.54 50 119596 895 64378191
Pulmonary oedema 118.50 12.54 368 119278 78306 64300780
Device infusion issue 118.01 12.54 60 119586 1698 64377388
Complication associated with device 113.48 12.54 140 119506 14940 64364146
Stomatitis 112.27 12.54 32 119614 109573 64269513
Peripheral swelling 109.91 12.54 714 118932 208439 64170647
Overdose 106.38 12.54 84 119562 159482 64219604
Abdominal distension 106.08 12.54 405 119241 95589 64283497
Rash 104.81 12.54 466 119180 458083 63921003
Confusional state 102.60 12.54 206 119440 260938 64118148
Cardiac pacemaker insertion 101.35 12.54 80 119566 4943 64374143
Catheter site irritation 99.96 12.54 38 119608 520 64378566
Joint swelling 98.02 12.54 155 119491 215227 64163859
Pancytopenia 97.36 12.54 74 119572 143235 64235851
Neutrophil count decreased 96.72 12.54 14 119632 77182 64301904
Pulmonary veno-occlusive disease 96.62 12.54 49 119597 1379 64377707
Maternal exposure during pregnancy 96.36 12.54 29 119617 95855 64283231
Catheter site vesicles 91.75 12.54 31 119615 294 64378792
Injection site discharge 89.98 12.54 33 119613 406 64378680
Presyncope 89.67 12.54 200 119446 34889 64344197
Hypotension 88.33 12.54 1087 118559 379887 63999199
Hypertension 86.82 12.54 223 119423 259038 64120048
Device connection issue 86.45 12.54 39 119607 840 64378246
Glossodynia 85.21 12.54 10 119636 64686 64314400
Seizure 84.90 12.54 111 119535 166781 64212305
Epistaxis 84.84 12.54 384 119262 97747 64281339
Hepatic enzyme increased 84.61 12.54 70 119576 129873 64249213
Musculoskeletal stiffness 84.48 12.54 63 119583 123143 64255943
Pericardial effusion 84.26 12.54 209 119437 39045 64340041
Device related sepsis 82.93 12.54 72 119574 5083 64374003
Hyponatraemia 81.42 12.54 93 119553 148246 64230840
Cardiac disorder 81.20 12.54 258 119388 55558 64323528
Walking distance test abnormal 80.74 12.54 35 119611 683 64378403
Drug reaction with eosinophilia and systemic symptoms 80.60 12.54 5 119641 54212 64324874
Paracentesis 78.82 12.54 41 119605 1218 64377868
Anaphylactic reaction 78.23 12.54 16 119630 68648 64310438
Bradycardia 77.82 12.54 63 119583 118156 64260930
Heart rate increased 76.43 12.54 374 119272 98301 64280785
Hypersensitivity 76.24 12.54 156 119490 196296 64182790
Dyspnoea at rest 75.84 12.54 75 119571 6254 64372832
Drug intolerance 75.78 12.54 146 119500 187846 64191240
White blood cell count decreased 73.30 12.54 112 119534 157725 64221361
Faeces soft 73.18 12.54 71 119575 5784 64373302
Infusion site warmth 73.16 12.54 37 119609 1035 64378051
Ascites 72.98 12.54 267 119379 61734 64317352
C-reactive protein increased 72.52 12.54 43 119603 94866 64284220
Suicide attempt 72.21 12.54 21 119625 70986 64308100
Agitation 71.92 12.54 37 119609 88330 64290756
Condition aggravated 71.10 12.54 1026 118620 371400 64007686
Rash maculo-papular 70.93 12.54 4 119642 47022 64332064
Depressed level of consciousness 69.46 12.54 32 119614 81404 64297682
Sinus congestion 69.40 12.54 112 119534 15327 64363759
Intentional product use issue 69.01 12.54 46 119600 95318 64283768
Lactic acidosis 68.55 12.54 15 119631 61395 64317691
Pericarditis 68.32 12.54 16 119630 62500 64316586
Coma 67.93 12.54 39 119607 87576 64291510
Haemoptysis 67.08 12.54 222 119424 48826 64330260
Cardiac ablation 65.76 12.54 41 119605 1731 64377355
Electrocardiogram QT prolonged 65.05 12.54 33 119613 79415 64299671
Intentional overdose 64.26 12.54 44 119602 89900 64289186
Sedation 64.20 12.54 3 119643 41459 64337627
Bone marrow failure 64.18 12.54 7 119639 47945 64331141
Cardiac operation 64.07 12.54 57 119589 4157 64374929
Lower respiratory tract infection 64.06 12.54 49 119597 94565 64284521
Blood pressure decreased 62.71 12.54 321 119325 85878 64293208
Therapy non-responder 62.36 12.54 265 119381 65634 64313452
Liver transplant 61.52 12.54 55 119591 4037 64375049
Oxygen therapy 60.74 12.54 43 119603 2250 64376836
Optic ischaemic neuropathy 60.56 12.54 45 119601 2540 64376546
Infusion site induration 60.53 12.54 30 119616 803 64378283
Hyperkalaemia 60.42 12.54 59 119587 101070 64278016
Metabolic acidosis 60.34 12.54 28 119618 70930 64308156
Infusion site pruritus 60.23 12.54 45 119601 2561 64376525
Blood pressure systolic increased 59.60 12.54 10 119636 49443 64329643
Infusion site abscess 58.88 12.54 20 119626 193 64378893
Psoriatic arthropathy 58.75 12.54 6 119640 43275 64335811
Nasopharyngitis 58.37 12.54 588 119058 195485 64183601
Chest discomfort 58.26 12.54 392 119254 115714 64263372
Urticaria 57.98 12.54 116 119530 147201 64231885
Atrial septal defect repair 56.95 12.54 23 119623 373 64378713
General physical health deterioration 56.68 12.54 192 119454 204233 64174853
Cytomegalovirus infection 56.62 12.54 3 119643 37196 64341890
Pruritus 56.33 12.54 344 119302 312056 64067030
Cardiac failure congestive 55.75 12.54 424 119222 130156 64248930
Catheter removal 55.31 12.54 25 119621 541 64378545
Atrial flutter 54.70 12.54 115 119531 19265 64359821
Catheter site warmth 54.32 12.54 20 119626 249 64378837
Pulmonary arterial pressure abnormal 54.27 12.54 26 119620 645 64378441
Injection site infection 54.15 12.54 37 119609 1828 64377258
Device breakage 52.97 12.54 73 119573 8682 64370404
Helicobacter infection 52.90 12.54 5 119641 38357 64340729
Stent placement 52.39 12.54 58 119588 5513 64373573
Disease complication 52.06 12.54 51 119595 4204 64374882
Delirium 51.94 12.54 32 119614 69162 64309924
Impaired healing 51.20 12.54 24 119622 60449 64318637
Right ventricular dysfunction 50.83 12.54 38 119608 2165 64376921
Dialysis 50.81 12.54 103 119543 16817 64362269
Blood pressure increased 50.65 12.54 158 119488 172394 64206692
Disease progression 50.21 12.54 441 119205 141239 64237847
Right ventricular dilatation 50.04 12.54 32 119614 1413 64377673
Dizziness exertional 49.63 12.54 22 119624 454 64378632
Cognitive disorder 49.59 12.54 20 119626 55067 64324019
Cyanopsia 49.30 12.54 14 119632 69 64379017
Cardioversion 49.12 12.54 35 119611 1850 64377236
Hypocalcaemia 49.10 12.54 9 119637 41744 64337342
Hallucination 48.88 12.54 38 119608 72750 64306336
Hepatocellular injury 48.60 12.54 12 119634 45223 64333863
Neoplasm progression 47.81 12.54 9 119637 40955 64338131
Hypoglycaemia 47.55 12.54 58 119588 89834 64289252
Cardiac failure high output 47.17 12.54 18 119628 249 64378837
Infusion site irritation 47.03 12.54 21 119625 441 64378645
Dizziness postural 46.95 12.54 73 119573 9679 64369407
Blood creatine phosphokinase increased 46.93 12.54 25 119621 58533 64320553
Acute respiratory failure 46.62 12.54 200 119446 49734 64329352
Chemotherapy 46.38 12.54 31 119615 1476 64377610
Hyperglycaemia 46.04 12.54 28 119618 60940 64318146
Medical device change 46.02 12.54 21 119625 465 64378621
Migraine 45.99 12.54 234 119412 62443 64316643
Intentional product misuse 45.76 12.54 40 119606 72255 64306831
Psoriasis 44.98 12.54 40 119606 71663 64307423
Vision blurred 44.15 12.54 303 119343 90013 64289073
Discomfort 44.04 12.54 51 119595 80827 64298259
Osteoarthritis 43.90 12.54 32 119614 63304 64315782
Dyspepsia 43.85 12.54 277 119369 80035 64299051
Blood cholesterol increased 43.75 12.54 19 119627 50047 64329039
Disease recurrence 43.74 12.54 4 119642 31506 64347580
Emergency care 43.64 12.54 25 119621 902 64378184
Exposure during pregnancy 43.36 12.54 48 119598 77627 64301459
Lymphocyte count decreased 43.33 12.54 11 119635 40688 64338398
Angioedema 43.16 12.54 31 119615 61790 64317296
Suicidal ideation 43.11 12.54 36 119610 66506 64312580
Hypokalaemia 42.99 12.54 102 119544 121801 64257285
Deep vein thrombosis 42.96 12.54 81 119565 105101 64273985
Aspiration pleural cavity 42.92 12.54 29 119617 1406 64377680
Blood iron decreased 42.67 12.54 79 119567 12063 64367023
Drug resistance 42.52 12.54 7 119639 35095 64343991
Infusion site rash 42.08 12.54 26 119620 1080 64378006
Blood lactate dehydrogenase increased 41.42 12.54 6 119640 33072 64346014
Seasonal allergy 40.84 12.54 76 119570 11650 64367436
Wound 40.81 12.54 49 119597 76428 64302658
Red blood cell sedimentation rate increased 40.70 12.54 5 119641 31230 64347856
Drug titration error 40.68 12.54 24 119622 916 64378170
Abdominal cavity drainage 40.66 12.54 22 119624 709 64378377
Multiple allergies 40.59 12.54 52 119594 5762 64373324
Injury 40.51 12.54 27 119619 55965 64323121
Extra dose administered 40.41 12.54 56 119590 6694 64372392
Injection site bruising 40.36 12.54 9 119637 36364 64342722
Head discomfort 40.35 12.54 76 119570 11758 64367328
Injection site reaction 40.31 12.54 18 119628 46646 64332440
Hepatitis 40.30 12.54 17 119629 45565 64333521
Throat irritation 40.29 12.54 143 119503 32568 64346518
Osteonecrosis of jaw 40.08 12.54 12 119634 39813 64339273
Dysarthria 39.91 12.54 31 119615 59375 64319711
Fatigue 39.76 12.54 1732 117914 746998 63632088
Tremor 39.21 12.54 142 119504 148088 64230998
Mobility decreased 38.79 12.54 62 119584 85778 64293308
Pneumonitis 38.21 12.54 23 119623 50342 64328744
Aggression 38.14 12.54 19 119627 46213 64332873
Multiple organ dysfunction syndrome 38.08 12.54 82 119564 101331 64277755
Neuropathy peripheral 37.84 12.54 103 119543 117422 64261664
Depression 37.81 12.54 193 119453 183098 64195988
Muscle injury 37.67 12.54 3 119643 26434 64352652
Heart and lung transplant 37.55 12.54 14 119632 181 64378905
Sleep disorder due to general medical condition, insomnia type 37.38 12.54 3 119643 26267 64352819
Blister 37.04 12.54 58 119588 80909 64298177
Intentional self-injury 37.00 12.54 5 119641 29039 64350047
Catheter site related reaction 37.00 12.54 23 119623 966 64378120
Stevens-Johnson syndrome 36.96 12.54 9 119637 34240 64344846
Type 2 diabetes mellitus 36.59 12.54 9 119637 34011 64345075
Deafness unilateral 36.13 12.54 39 119607 3603 64375483
Exercise tolerance decreased 36.12 12.54 57 119589 7653 64371433
Mouth ulceration 36.05 12.54 8 119638 32436 64346650
Drug ineffective for unapproved indication 35.99 12.54 7 119639 31126 64347960
Agranulocytosis 35.87 12.54 13 119633 38216 64340870
Eosinophilia 35.64 12.54 13 119633 38063 64341023
Tubulointerstitial nephritis 35.63 12.54 7 119639 30902 64348184
Psychotic disorder 35.57 12.54 10 119636 34568 64344518
Neutrophil count increased 35.47 12.54 3 119643 25171 64353915
Hospice care 35.21 12.54 56 119590 7569 64371517
Hallucination, visual 34.97 12.54 5 119641 27829 64351257
Rehabilitation therapy 34.92 12.54 26 119620 1472 64377614
Renal disorder 34.84 12.54 144 119502 35221 64343865
Device physical property issue 34.73 12.54 30 119616 2103 64376983
Pulmonary arterial wedge pressure increased 34.58 12.54 17 119629 447 64378639
Systemic lupus erythematosus 34.19 12.54 57 119589 77555 64301531
Body temperature decreased 34.16 12.54 4 119642 25924 64353162
Device issue 34.13 12.54 106 119540 22542 64356544
Injection site pain 34.12 12.54 100 119546 111308 64267778
Fracture of penis 34.09 12.54 12 119634 130 64378956
Cor pulmonale 34.03 12.54 29 119617 1996 64377090
Dysentery 34.02 12.54 21 119625 871 64378215
Disorientation 34.00 12.54 32 119614 55796 64323290
Cardiac output increased 33.93 12.54 13 119633 182 64378904
Somnolence 33.73 12.54 230 119416 203415 64175671
Productive cough 33.67 12.54 242 119404 72961 64306125
Internal haemorrhage 33.62 12.54 55 119591 7612 64371474
Product use issue 33.45 12.54 156 119490 151559 64227527
Influenza 33.38 12.54 323 119323 106208 64272878
Cholestasis 33.33 12.54 21 119625 44851 64334235
Myelosuppression 33.14 12.54 3 119643 23827 64355259
Hypomagnesaemia 32.95 12.54 14 119632 37362 64341724
Nocturnal dyspnoea 32.88 12.54 24 119622 1318 64377768
Abdominal pain upper 32.83 12.54 481 119165 174549 64204537
Blood potassium decreased 32.61 12.54 155 119491 40244 64338842
Multiple sclerosis relapse 32.32 12.54 18 119628 41117 64337969
Infusion site oedema 32.31 12.54 18 119628 615 64378471
Blood glucose increased 32.29 12.54 85 119561 97988 64281098
Catheterisation cardiac abnormal 32.26 12.54 14 119632 274 64378812
Palmar-plantar erythrodysaesthesia syndrome 32.24 12.54 7 119639 28812 64350274
Acute myeloid leukaemia 32.12 12.54 6 119640 27457 64351629
Gout 32.07 12.54 100 119546 21313 64357773
Gastritis hypertrophic 31.92 12.54 9 119637 43 64379043
Inappropriate schedule of product administration 31.91 12.54 78 119568 92208 64286878
Thrombosis in device 31.76 12.54 43 119603 5028 64374058
Treatment noncompliance 31.66 12.54 162 119484 43320 64335766
Viral infection 31.64 12.54 142 119504 35998 64343088
Posterior reversible encephalopathy syndrome 31.61 12.54 3 119643 22943 64356143
Oxygen saturation abnormal 31.57 12.54 36 119610 3535 64375551
Catheter site discolouration 31.43 12.54 11 119635 117 64378969
Dyskinesia 31.29 12.54 17 119629 39371 64339715
Left ventricular failure 31.14 12.54 56 119590 8361 64370725
Swollen tongue 30.96 12.54 13 119633 34941 64344145
Milk-alkali syndrome 30.74 12.54 22 119624 1171 64377915
Altered state of consciousness 30.64 12.54 16 119630 37886 64341200
Myoclonus 30.44 12.54 5 119641 25113 64353973
Loss of consciousness 30.34 12.54 414 119232 147951 64231135
Application site pruritus 30.15 12.54 35 119611 3504 64375582
Sinus disorder 30.13 12.54 84 119562 16824 64362262
Encephalopathy 30.01 12.54 39 119607 58780 64320306
Back pain 29.92 12.54 640 119006 249531 64129555
Terminal state 29.86 12.54 39 119607 4405 64374681
Product prescribing error 29.85 12.54 14 119632 35255 64343831
Catheter site scab 29.63 12.54 12 119634 196 64378890
Infusion site cellulitis 29.56 12.54 13 119633 263 64378823
Upper respiratory tract congestion 29.39 12.54 28 119618 2230 64376856
Hernia repair 29.10 12.54 25 119621 1740 64377346
Cardio-respiratory arrest 28.92 12.54 90 119556 98303 64280783
Respiratory failure 28.68 12.54 439 119207 160744 64218342
Mineral supplementation 28.68 12.54 18 119628 769 64378317
Ear congestion 28.63 12.54 27 119619 2123 64376963
Drug dependence 28.54 12.54 13 119633 33299 64345787
Sinus tachycardia 28.46 12.54 12 119634 32176 64346910
Atrial septal defect 28.45 12.54 24 119622 1629 64377457
Irritable bowel syndrome 28.44 12.54 17 119629 37352 64341734
Paranasal sinus discomfort 28.22 12.54 32 119614 3123 64375963
Osteoporosis 28.21 12.54 22 119624 42058 64337028
Scleroderma associated digital ulcer 28.17 12.54 7 119639 18 64379068
Mechanical ventilation 28.16 12.54 28 119618 2350 64376736
Haematuria 27.96 12.54 43 119603 60428 64318658
Right-to-left cardiac shunt 27.84 12.54 11 119635 168 64378918
Withdrawal syndrome 27.76 12.54 5 119641 23487 64355599
Medication error 27.75 12.54 31 119615 49935 64329151
Systemic scleroderma 27.71 12.54 19 119627 944 64378142
Pulmonary hypertensive crisis 27.68 12.54 13 119633 308 64378778
Wrong technique in product usage process 27.45 12.54 49 119597 64925 64314161
Heart valve replacement 27.41 12.54 17 119629 711 64378375
Plasma cell myeloma 27.37 12.54 27 119619 46048 64333038
Poisoning 27.32 12.54 4 119642 21875 64357211
Skin lesion 27.20 12.54 17 119629 36465 64342621
Lymphopenia 27.18 12.54 7 119639 25650 64353436
Catheter site dermatitis 27.05 12.54 9 119637 81 64379005
Pulmonary embolism 26.94 12.54 160 119486 146196 64232890
Priapism 26.92 12.54 35 119611 3935 64375151
Weight increased 26.87 12.54 550 119096 212798 64166288
Hot flush 26.82 12.54 162 119484 46073 64333013
Localised oedema 26.81 12.54 48 119598 7143 64371943
Cholecystectomy 26.66 12.54 51 119595 7981 64371105
Emotional distress 26.58 12.54 17 119629 36021 64343065
Diabetes mellitus inadequate control 26.39 12.54 4 119642 21317 64357769
Polyneuropathy 26.38 12.54 3 119643 19891 64359195
Iron deficiency anaemia 26.37 12.54 95 119551 21794 64357292
Pulmonary artery dilatation 25.83 12.54 13 119633 360 64378726
Osteonecrosis 25.82 12.54 10 119636 28219 64350867
Transaminases increased 25.51 12.54 27 119619 44567 64334519
Cardiac flutter 25.45 12.54 35 119611 4154 64374932
Drug eruption 25.38 12.54 18 119628 36118 64342968
Diuretic therapy 25.29 12.54 10 119636 153 64378933
Obstructive airways disorder 25.20 12.54 6 119640 23179 64355907
Infusion site vesicles 25.18 12.54 13 119633 380 64378706
Liver injury 25.15 12.54 12 119634 29920 64349166
N-terminal prohormone brain natriuretic peptide increased 25.11 12.54 32 119614 3527 64375559
Hepatic cirrhosis 25.06 12.54 106 119540 26192 64352894
Catheter site erosion 24.99 12.54 8 119638 63 64379023
Weight decreased 24.85 12.54 700 118946 285039 64094047
Diabetes mellitus 24.74 12.54 54 119592 66420 64312666
Metapneumovirus infection 24.71 12.54 21 119625 1440 64377646
Central venous catheter removal 24.69 12.54 13 119633 396 64378690
Accidental exposure to product 24.68 12.54 9 119637 26355 64352731
Right ventricular systolic pressure increased 24.50 12.54 17 119629 861 64378225
Pulmonary pain 24.47 12.54 27 119619 2557 64376529
Anaphylactic shock 24.22 12.54 13 119633 30315 64348771
Disseminated intravascular coagulation 24.22 12.54 15 119631 32333 64346753
Blood creatinine increased 24.18 12.54 150 119496 135632 64243454
Acute respiratory distress syndrome 24.08 12.54 22 119624 38913 64340173
Concomitant disease progression 24.03 12.54 30 119616 3239 64375847
Asthma 24.01 12.54 93 119553 95132 64283954
Blood pressure fluctuation 23.87 12.54 37 119609 51834 64327252
Infusion site discolouration 23.64 12.54 14 119632 538 64378548
Oral herpes 23.55 12.54 6 119640 22146 64356940
Cytokine release syndrome 23.42 12.54 5 119641 20824 64358262
Erection increased 23.27 12.54 12 119634 350 64378736
Catheter culture positive 23.17 12.54 10 119636 193 64378893
Contusion 22.92 12.54 121 119525 113844 64265242
Catheter site extravasation 22.90 12.54 12 119634 362 64378724
Sinus bradycardia 22.85 12.54 7 119639 22886 64356200
Paraesthesia 22.73 12.54 151 119495 134371 64244715
Respiratory syncytial virus infection 22.72 12.54 45 119601 7223 64371863
Ear discomfort 22.67 12.54 45 119601 7235 64371851
Haematopoietic stem cell mobilisation 22.57 12.54 10 119636 206 64378880
Creatinine renal clearance abnormal 22.52 12.54 13 119633 476 64378610
Haemophagocytic lymphohistiocytosis 22.51 12.54 3 119643 17606 64361480
Bursitis 22.50 12.54 6 119640 21479 64357607
Gastroenteritis viral 22.40 12.54 84 119562 19645 64359441
Septic shock 22.31 12.54 110 119536 105327 64273759
Transplant rejection 22.16 12.54 3 119643 17398 64361688
Cardiac resynchronisation therapy 22.14 12.54 6 119640 24 64379062
Infusion site inflammation 22.10 12.54 10 119636 217 64378869
Female sterilisation 21.97 12.54 10 119636 220 64378866
Proteinuria 21.97 12.54 12 119634 27711 64351375
Inflammation 21.94 12.54 56 119590 65244 64313842
Ejection fraction decreased 21.93 12.54 13 119633 28694 64350392
Rhinorrhoea 21.92 12.54 188 119458 59781 64319305
Drug-induced liver injury 21.91 12.54 34 119612 47609 64331477
Catheter site mass 21.77 12.54 7 119639 56 64379030
Incorrect route of product administration 21.73 12.54 8 119638 23290 64355796
Myocarditis 21.55 12.54 3 119643 17040 64362046
Intentional dose omission 21.42 12.54 38 119608 5614 64373472
Wrong dose 21.32 12.54 18 119628 1223 64377863
Progressive multifocal leukoencephalopathy 21.29 12.54 4 119642 18228 64360858
Pancreatitis acute 21.26 12.54 29 119617 42826 64336260
Fibromyalgia 21.15 12.54 21 119625 35710 64343376
Acute hepatic failure 21.14 12.54 11 119635 26101 64352985
Vasculitis 21.06 12.54 4 119642 18091 64360995
Orthopnoea 21.06 12.54 50 119596 9084 64370002
Lung disorder 20.99 12.54 188 119458 60512 64318574
Toxic skin eruption 20.94 12.54 5 119641 19279 64359807
Shock 20.94 12.54 24 119622 38216 64340870
Delusion 20.93 12.54 4 119642 18010 64361076
Infusion site nodule 20.87 12.54 10 119636 248 64378838
Life support 20.85 12.54 12 119634 437 64378649
Mitral valve replacement 20.84 12.54 11 119635 337 64378749
Abnormal behaviour 20.79 12.54 19 119627 33603 64345483
Generalised tonic-clonic seizure 20.77 12.54 26 119620 39831 64339255
Haematospermia 20.66 12.54 10 119636 254 64378832
Product administration interrupted 20.58 12.54 17 119629 1121 64377965
Aspergillus infection 20.44 12.54 3 119643 16376 64362710
Blood calcium decreased 20.34 12.54 11 119635 25543 64353543
Leukocytosis 20.32 12.54 24 119622 37716 64341370
Respiratory depression 20.32 12.54 9 119637 23434 64355652
Therapy cessation 20.24 12.54 116 119530 32373 64346713
Drug withdrawal syndrome 20.18 12.54 17 119629 31274 64347812
Sluggishness 20.06 12.54 37 119609 5633 64373453
Bronchitis 20.04 12.54 298 119348 108445 64270641
Primary biliary cholangitis 20.04 12.54 16 119630 1005 64378081
Immunodeficiency 20.01 12.54 3 119643 16121 64362965
Platelet count increased 20.00 12.54 5 119641 18691 64360395
Colitis 19.96 12.54 50 119596 58624 64320462
Transplant 19.93 12.54 15 119631 863 64378223
Labelled drug-drug interaction medication error 19.87 12.54 8 119638 22054 64357032
Application site hypersensitivity 19.83 12.54 10 119636 278 64378808
Cardiac pacemaker replacement 19.79 12.54 11 119635 374 64378712
Colon operation 19.74 12.54 11 119635 376 64378710
Decreased activity 19.56 12.54 42 119604 7138 64371948
Pulmonary congestion 19.55 12.54 92 119554 23788 64355298
Product quality issue 19.45 12.54 16 119630 29783 64349303
Subcutaneous drug absorption impaired 19.31 12.54 5 119641 16 64379070
Chronic obstructive pulmonary disease 19.19 12.54 209 119437 70839 64308247
Hyperthermia 19.06 12.54 3 119643 15547 64363539
Osteopenia 19.04 12.54 3 119643 15537 64363549
Myelodysplastic syndrome 19.02 12.54 14 119632 27565 64351521
Bone disorder 18.89 12.54 4 119642 16755 64362331
Vascular cauterisation 18.88 12.54 7 119639 89 64378997
Pulmonary artery aneurysm 18.85 12.54 8 119638 148 64378938
Alanine aminotransferase increased 18.80 12.54 166 119480 138865 64240221
Bronchopulmonary aspergillosis 18.76 12.54 6 119640 19079 64360007
Polypectomy 18.66 12.54 15 119631 951 64378135
Multiple sclerosis 18.54 12.54 6 119640 18935 64360151
Blood triglycerides increased 18.42 12.54 6 119640 18860 64360226
N-terminal prohormone brain natriuretic peptide 18.34 12.54 6 119640 51 64379035
Urinary retention 18.28 12.54 40 119606 49161 64329925
Nervous system disorder 18.27 12.54 10 119636 23068 64356018
Tinnitus 18.17 12.54 117 119529 34016 64345070
Nephropathy toxic 18.14 12.54 5 119641 17509 64361577
Catheter site nodule 18.13 12.54 6 119640 53 64379033
Blood testosterone decreased 18.07 12.54 21 119625 2104 64376982
Skin exfoliation 17.94 12.54 35 119611 44850 64334236
Oropharyngeal pain 17.75 12.54 247 119399 88620 64290466
Respiratory tract congestion 17.67 12.54 68 119578 16097 64362989
Obesity 17.65 12.54 8 119638 20554 64358532
Therapeutic procedure 17.65 12.54 13 119633 724 64378362
Cataract operation 17.64 12.54 28 119618 3778 64375308
Atrial tachycardia 17.63 12.54 27 119619 3532 64375554
White blood cell count increased 17.60 12.54 63 119583 65951 64313135
Device malfunction 17.52 12.54 72 119574 17561 64361525
Coagulopathy 17.51 12.54 20 119626 31900 64347186
Cancer surgery 17.49 12.54 13 119633 734 64378352
Orthostatic hypotension 17.37 12.54 38 119608 46700 64332386
Epilepsy 17.34 12.54 22 119624 33509 64345577
Platelet transfusion 17.28 12.54 19 119627 1792 64377294
Basal cell carcinoma 17.27 12.54 19 119627 30819 64348267
Cor pulmonale acute 17.26 12.54 12 119634 610 64378476
Balloon atrial septostomy 17.25 12.54 7 119639 115 64378971
Pleural effusion 17.17 12.54 330 119316 126229 64252857
Diabetic ketoacidosis 17.15 12.54 18 119628 29827 64349259
Prophylaxis 17.13 12.54 4 119642 7 64379079
Heart valve operation 17.09 12.54 8 119638 188 64378898
Feeling cold 17.08 12.54 88 119558 23590 64355496
Skin necrosis 17.04 12.54 3 119643 14326 64364760
Eczema 16.99 12.54 18 119628 29702 64349384
Muscle twitching 16.93 12.54 7 119639 18991 64360095
Vomiting 16.92 12.54 1213 118433 549904 63829182
Peritonitis 16.88 12.54 13 119633 25010 64354076
Muscle spasticity 16.81 12.54 5 119641 16664 64362422
Joint stiffness 16.73 12.54 19 119627 30385 64348701
Tracheostomy 16.73 12.54 15 119631 1105 64377981
First bite syndrome 16.65 12.54 5 119641 31 64379055
Hepatic cytolysis 16.58 12.54 3 119643 14046 64365040
Herpes zoster 16.53 12.54 83 119563 79104 64299982
Catheter site urticaria 16.51 12.54 5 119641 32 64379054
Jugular vein distension 16.46 12.54 16 119630 1306 64377780
Acute myocardial infarction 16.37 12.54 70 119576 69648 64309438
Acute right ventricular failure 16.33 12.54 9 119637 301 64378785
Hypoaesthesia 16.31 12.54 172 119474 138936 64240150
Clostridium difficile infection 16.30 12.54 119 119527 36044 64343042
Diet noncompliance 16.19 12.54 10 119636 415 64378671
Graft versus host disease 16.19 12.54 3 119643 13810 64365276
Infusion site dermatitis 16.17 12.54 4 119642 10 64379076
Hyperhidrosis 16.08 12.54 151 119495 124769 64254317
Mastectomy 15.94 12.54 14 119632 1004 64378082
Systemic sclerosis pulmonary 15.90 12.54 4 119642 11 64379075
Product supply issue 15.89 12.54 16 119630 1363 64377723
Application site irritation 15.85 12.54 17 119629 1559 64377527
Arteriovenous malformation 15.85 12.54 17 119629 1559 64377527
CREST syndrome 15.83 12.54 10 119636 432 64378654
Hypertensive crisis 15.82 12.54 7 119639 18241 64360845
Endotracheal intubation 15.82 12.54 27 119619 3868 64375218
Oral candidiasis 15.73 12.54 12 119634 23200 64355886
Pregnancy test positive 15.66 12.54 6 119640 84 64379002
Biopsy bone marrow 15.48 12.54 9 119637 334 64378752
Brain operation 15.46 12.54 11 119635 580 64378506
Hyperlipidaemia 15.42 12.54 12 119634 22964 64356122
Pericardial drainage 15.41 12.54 9 119637 337 64378749
Klebsiella infection 15.32 12.54 3 119643 13278 64365808
Pulmonary haemosiderosis 15.18 12.54 4 119642 14 64379072
Decreased appetite 15.11 12.54 652 118994 280637 64098449
Infusion site reaction 15.11 12.54 19 119627 2067 64377019
Thrombotic microangiopathy 15.07 12.54 6 119640 16649 64362437
Hypoalbuminaemia 14.98 12.54 7 119639 17667 64361419
Angina unstable 14.96 12.54 5 119641 15462 64363624
Adrenal insufficiency 14.77 12.54 12 119634 22475 64356611
Disturbance in attention 14.77 12.54 34 119612 41040 64338046
Skin irritation 14.76 12.54 44 119602 9150 64369936
Gallbladder operation 14.75 12.54 17 119629 1688 64377398
Pericardial excision 14.65 12.54 5 119641 49 64379037
Biliary catheter insertion 14.65 12.54 6 119640 101 64378985
Metastases to bone 14.59 12.54 10 119636 20425 64358661
Cardiothoracic ratio increased 14.56 12.54 5 119641 50 64379036
Atrial fibrillation 14.53 12.54 418 119228 170671 64208415
Right atrial pressure increased 14.50 12.54 8 119638 268 64378818
Catheter site induration 14.47 12.54 5 119641 51 64379035
Infusion site pustule 14.39 12.54 5 119641 52 64379034
Infusion site mass 14.38 12.54 13 119633 968 64378118
Purpura 14.36 12.54 7 119639 17239 64361847
Medical procedure 14.34 12.54 8 119638 274 64378812
Gastric disorder 14.28 12.54 98 119548 29099 64349987
Dysphagia 14.23 12.54 128 119518 106684 64272402
Bendopnoea 14.21 12.54 4 119642 19 64379067
Mitral perforation 14.21 12.54 4 119642 19 64379067
Flatulence 14.20 12.54 114 119532 35552 64343534
Middle ear effusion 14.15 12.54 18 119628 1981 64377105
Pulmonary capillary haemangiomatosis 14.14 12.54 5 119641 55 64379031
Hypothyroidism 14.14 12.54 34 119612 40423 64338663
Blood culture negative 14.07 12.54 7 119639 189 64378897
Catheter site thrombosis 14.03 12.54 7 119639 190 64378896
Anhedonia 14.03 12.54 4 119642 13702 64365384
Mitral valve incompetence 14.01 12.54 16 119630 25522 64353564
Dermatitis 14.00 12.54 8 119638 18021 64361065
Palliative care 14.00 12.54 11 119635 675 64378411
Anuria 13.91 12.54 9 119637 18955 64360131
Dialysis device insertion 13.90 12.54 5 119641 58 64379028
Spontaneous penile erection 13.89 12.54 6 119640 116 64378970
Ill-defined disorder 13.88 12.54 39 119607 44013 64335073
Injection site pruritus 13.85 12.54 31 119615 37795 64341291
Respiratory arrest 13.84 12.54 51 119595 52934 64326152
Infusion site lymphadenopathy 13.80 12.54 3 119643 3 64379083
Catheter site exfoliation 13.80 12.54 3 119643 3 64379083
Vocal cord operation 13.80 12.54 3 119643 3 64379083
Pseudomonas infection 13.80 12.54 8 119638 17875 64361211
Catheter site cellulitis 13.74 12.54 9 119637 414 64378672
Dyschromatopsia 13.72 12.54 11 119635 695 64378391
Joint effusion 13.67 12.54 4 119642 13469 64365617
Erythema multiforme 13.65 12.54 6 119640 15695 64363391
Fracture 13.62 12.54 9 119637 18746 64360340
Patient-device incompatibility 13.62 12.54 6 119640 122 64378964
Intracardiac pressure increased 13.57 12.54 4 119642 23 64379063
Pyrexia 13.37 12.54 875 118771 557769 63821317
Product substitution issue 13.32 12.54 67 119579 17794 64361292
Parkinsonism 13.30 12.54 5 119641 14368 64364718
Gastrointestinal tube insertion 13.27 12.54 15 119631 1459 64377627
Renal injury 13.25 12.54 6 119640 15423 64363663
Endarterectomy 13.24 12.54 8 119638 319 64378767
Pulmonary vein occlusion 13.22 12.54 6 119640 131 64378955
Product complaint 13.18 12.54 3 119643 11951 64367135
Hypercholesterolaemia 13.17 12.54 6 119640 15367 64363719
Bedridden 13.15 12.54 45 119601 10064 64369022
Jaundice 13.13 12.54 46 119600 48466 64330620
Liver function test abnormal 13.13 12.54 61 119585 59340 64319746
Intervertebral disc degeneration 13.12 12.54 4 119642 13116 64365970
Myositis 13.11 12.54 7 119639 16370 64362716
Colitis ulcerative 13.10 12.54 14 119632 23014 64356072
Biopsy lung 13.10 12.54 7 119639 220 64378866
Connective tissue disorder 13.09 12.54 13 119633 1089 64377997
Mydriasis 13.08 12.54 6 119640 15306 64363780
Vena cava filter insertion 13.06 12.54 6 119640 135 64378951
Ataxia 13.05 12.54 13 119633 22071 64357015
Injection site mass 12.94 12.54 8 119638 17262 64361824
Pyelonephritis 12.93 12.54 8 119638 17258 64361828
Therapeutic embolisation 12.86 12.54 9 119637 462 64378624
Application site vesicles 12.84 12.54 14 119632 1308 64377778
Photosensitivity reaction 12.83 12.54 9 119637 18164 64360922
Ecchymosis 12.77 12.54 5 119641 14017 64365069
Pancreatitis 12.71 12.54 62 119584 59545 64319541
Injection site pustule 12.68 12.54 5 119641 76 64379010
Activated partial thromboplastin time prolonged 12.67 12.54 4 119642 12827 64366259
Thoracic cavity drainage 12.65 12.54 7 119639 236 64378850
Metastases to central nervous system 12.60 12.54 5 119641 13907 64365179
Sedative therapy 12.59 12.54 3 119643 6 64379080
Rash erythematous 12.58 12.54 47 119599 48586 64330500
Head injury 12.55 12.54 104 119542 32738 64346348

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C02KX52 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
OTHER ANTIHYPERTENSIVES
Antihypertensives for pulmonary arterial hypertension
ATC G04BE08 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
UROLOGICALS
Drugs used in erectile dysfunction
ATC G04CA54 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
FDA MoA N0000020026 Phosphodiesterase 5 Inhibitors
FDA EPC N0000175599 Phosphodiesterase 5 Inhibitor
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D058986 Phosphodiesterase 5 Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D064804 Urological Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:71942 PDE5 inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pulmonary hypertension indication 70995007 DOID:6432
Benign prostatic hyperplasia indication 266569009
Impotence indication 397803000
Induratio penis plastica contraindication 1335005 DOID:8616
Priapism contraindication 6273006 DOID:9286
Hearing loss contraindication 15188001
Myocardial infarction contraindication 22298006 DOID:5844
Alcohol intoxication contraindication 25702006
Fibrosis of corpus cavernosum contraindication 32608004
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aortic valve stenosis contraindication 60573004 DOID:1712
Blood coagulation disorder contraindication 64779008 DOID:1247
Leukemia, disease contraindication 93143009 DOID:1240
Multiple myeloma contraindication 109989006 DOID:9538
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002
Acute peptic ulcer contraindication 196682000
Cerebrovascular accident contraindication 230690007
Penis bent contraindication 249247007
Exercise-induced angina contraindication 300995000
Functional visual loss contraindication 313165001
Idiopathic hypertrophic subaortic stenosis contraindication 360465008
Acute coronary syndrome contraindication 394659003
Anterior ischemic optic neuropathy contraindication 404659001
Hypertensive urgency contraindication 443482000
Pigmentary Retinopathy contraindication
Severe Autonomic Insufficiency contraindication
Life-Threatening Cardiac Arrhythmias contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.3 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme INHIBITOR Ki 8 CHEMBL CHEMBL
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Enzyme IC50 7.48 CHEMBL
Phosphodiesterase 6 Enzyme IC50 6.01 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4 CHEMBL
Acetylcholinesterase Enzyme IC50 4.58 CHEMBL
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme Ki 8.30 CHEMBL
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme IC50 8.48 CHEMBL
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha Enzyme IC50 5.52 CHEMBL
Phosphodiesterase 6 Enzyme IC50 5.29 CHEMBL

External reference:

IDSource
4021415 VUID
N0000148829 NUI
D02008 KEGG_DRUG
4021415 VANDF
C1176316 UMLSCUI
CHEBI:71940 CHEBI
CIA PDB_CHEM_ID
CHEMBL779 ChEMBL_ID
DB00820 DRUGBANK_ID
D000068581 MESH_DESCRIPTOR_UI
110635 PUBCHEM_CID
7299 IUPHAR_LIGAND_ID
8136 INN_ID
742SXX0ICT UNII
303263 RXNORM
17580 MMSL
245338 MMSL
47489 MMSL
d04896 MMSL
009874 NDDF
407111005 SNOMEDCT_US
407734006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4462 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4462 TABLET, FILM COATED 5 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4463 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4463 TABLET, FILM COATED 10 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4464 TABLET, FILM COATED 20 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4464 TABLET, FILM COATED 20 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4465 TABLET, FILM COATED 2.50 mg ORAL NDA 34 sections
Cialis HUMAN PRESCRIPTION DRUG LABEL 1 0002-4465 TABLET, FILM COATED 2.50 mg ORAL NDA 34 sections
Tadalafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-3016 TABLET, FILM COATED 2.50 mg ORAL ANDA 28 sections
Tadalafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-3017 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Tadalafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-3018 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Tadalafil HUMAN PRESCRIPTION DRUG LABEL 1 0093-3019 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
ALYQ HUMAN PRESCRIPTION DRUG LABEL 1 0093-3334 TABLET, FILM COATED 20 mg ORAL ANDA 27 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-565 TABLET 2.50 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-565 TABLET 2.50 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-566 TABLET 5 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-566 TABLET 5 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-567 TABLET 10 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-567 TABLET 10 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-568 TABLET 20 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-568 TABLET 20 mg ORAL ANDA 25 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-581 TABLET 20 mg ORAL ANDA 29 sections
TADALAFIL HUMAN PRESCRIPTION DRUG LABEL 1 13668-581 TABLET 20 mg ORAL ANDA 29 sections
CIALIS HUMAN PRESCRIPTION DRUG LABEL 1 16590-905 TABLET, FILM COATED 10 mg ORAL NDA 31 sections
Tadalafil Human Prescription Drug Label 1 16714-074 TABLET, FILM COATED 2.50 mg ORAL ANDA 28 sections
Tadalafil Human Prescription Drug Label 1 16714-075 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Tadalafil Human Prescription Drug Label 1 16714-076 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Tadalafil Human Prescription Drug Label 1 16714-077 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
Tadalafil HUMAN PRESCRIPTION DRUG LABEL 1 16729-369 TABLET, FILM COATED 2.50 mg ORAL ANDA 30 sections
Tadalafil HUMAN PRESCRIPTION DRUG LABEL 1 16729-370 TABLET, FILM COATED 5 mg ORAL ANDA 30 sections