doxazosin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihypertensive substances, prazosin derivatives 954 74191-85-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • doxazosin
  • doxazosin mesylate
  • doxazosine
  • doxazosin mesilate
A prazosin-related compound that is a selective alpha-1-adrenergic blocker.
  • Molecular weight: 451.48
  • Formula: C23H25N5O5
  • CLOGP: 3.58
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 1
  • TPSA: 112.27
  • ALOGS: -2.76
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.59 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 63 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.669 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 9.016 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 23.121 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 9.840 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 6.420 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 19.930 % High 1
herg hERG pIC50 5.547 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 4.498 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 32.734 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 4.430 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAPK10,MAPK7,MET,PDK2,PDK4,PIK3CA,PIK3CD,PIK3CG,PRKDC 20
kinase-selectivity-class PRKDC,TTK 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 16.711 High 1
mh-clint Mouse hepatocyte intrinsic clearance 52.119 High 1
mppb Mouse plasma protein binding (% unbound) 6.360 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 33.113 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 15.790 % High 1
rh-clint Rat hepatocyte intrinsic clearance 34.995 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 42.570 % High 1
rppb Rat plasma protein binding (% unbound) 4.960 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 5.236 uM High 1

Approvals:

DateAgencyCompanyOrphan
Nov. 2, 1990 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperkalaemia 187.46 13.44 148 23964 64816 90539519
Hyponatraemia 185.17 13.44 202 23910 133336 90470999
Hypotension 184.74 13.44 319 23793 325078 90279257
Syncope 181.03 13.44 199 23913 132464 90471871
Acute kidney injury 142.65 13.44 283 23829 320104 90284231
Drug interaction 132.54 13.44 252 23860 276201 90328134
Hypertensive crisis 118.05 13.44 68 24044 17716 90586619
Renal impairment 96.10 13.44 129 23983 105292 90499043
Angioedema 87.84 13.44 97 24015 64779 90539556
Blood pressure increased 84.97 13.44 172 23940 197045 90407290
Lip swelling 74.68 13.44 70 24042 38540 90565795
Bradycardia 73.97 13.44 101 24011 83746 90520589
Drug intolerance 71.19 13.44 16 24096 447575 90156760
Arthropathy 67.16 13.44 9 24103 366233 90238102
Glossodynia 66.54 13.44 5 24107 321774 90282561
Bladder prolapse 66.21 13.44 24 24088 2131 90602204
Urinary incontinence 64.89 13.44 64 24048 37502 90566833
Contraindicated product administered 63.39 13.44 6 24106 320133 90284202
Orthostatic hypotension 60.91 13.44 65 24047 41762 90562573
Dizziness 60.69 13.44 313 23799 588971 90015364
Treatment failure 59.37 13.44 6 24106 303922 90300413
Renal artery stenosis 58.61 13.44 22 24090 2155 90602180
Rectal prolapse 57.74 13.44 22 24090 2245 90602090
Systemic lupus erythematosus 57.40 13.44 13 24099 361883 90242452
Cardiospasm 55.29 13.44 24 24088 3422 90600913
Palmoplantar keratoderma 54.88 13.44 24 24088 3483 90600852
Presyncope 54.59 13.44 54 24058 31751 90572584
Gallbladder polyp 54.44 13.44 17 24095 954 90603381
Therapeutic product effect decreased 52.88 13.44 6 24106 277565 90326770
Sopor 52.17 13.44 47 24065 24597 90579738
Metabolic acidosis 52.04 13.44 69 24043 55607 90548728
Atrial tachycardia 51.01 13.44 27 24085 5963 90598372
Renal failure 50.25 13.44 109 24003 130898 90473437
Hypoglycaemia 49.70 13.44 76 24036 69772 90534563
Sleep terror 49.34 13.44 24 24088 4440 90599895
Muscle twitching 48.96 13.44 45 24067 24157 90580178
Pruritus genital 48.87 13.44 24 24088 4534 90599801
Loss of consciousness 48.54 13.44 112 24000 140126 90464209
Hepatic enzyme increased 47.98 13.44 18 24094 360718 90243617
Blood creatinine increased 47.94 13.44 92 24020 101294 90503041
Tubulointerstitial nephritis 47.19 13.44 45 24067 25298 90579037
Duodenal ulcer perforation 47.01 13.44 3 24109 221285 90383050
Wound 45.85 13.44 12 24100 302968 90301367
Sinus bradycardia 45.40 13.44 37 24075 16915 90587420
Tension headache 45.31 13.44 27 24085 7482 90596853
Diplopia 44.25 13.44 46 24066 28668 90575667
Carotid artery occlusion 44.09 13.44 25 24087 6317 90598018
Blood urea increased 43.81 13.44 47 24065 30366 90573969
Glomerular filtration rate decreased 43.35 13.44 36 24076 16896 90587439
Fibromyalgia 43.22 13.44 3 24109 206266 90398069
Vasculitis 41.70 13.44 40 24072 22653 90581682
Psoriatic arthropathy 40.92 13.44 6 24106 228329 90376006
Dehydration 40.73 13.44 129 23983 194318 90410017
Cardiac failure 39.60 13.44 89 24023 109407 90494928
Lactic acidosis 38.88 13.44 57 24055 50406 90553929
Discomfort 37.63 13.44 13 24099 274322 90330013
Immunisation 37.43 13.44 16 24096 2197 90602138
Thermal burn 37.42 13.44 23 24089 6739 90597596
Injection site inflammation 37.35 13.44 20 24092 4521 90599814
Ventricular tachycardia 37.04 13.44 39 24073 24669 90579666
Product use issue 36.83 13.44 21 24091 329898 90274437
Lower urinary tract symptoms 36.63 13.44 8 24104 106 90604229
Blood pressure inadequately controlled 36.57 13.44 22 24090 6202 90598133
Irritable bowel syndrome 35.93 13.44 6 24106 207442 90396893
Infusion related reaction 35.65 13.44 35 24077 416745 90187590
Ill-defined disorder 35.20 13.44 4 24108 184887 90419448
Hypokalaemia 35.14 13.44 95 24017 131021 90473314
Transient ischaemic attack 35.06 13.44 50 24062 43126 90561209
Type 2 diabetes mellitus 34.93 13.44 6 24106 203238 90401097
Cardiac failure congestive 34.33 13.44 79 24033 98615 90505720
Impaired healing 34.07 13.44 10 24102 234189 90370146
Anosmia 34.02 13.44 25 24087 9823 90594512
Myocardial infarction 33.80 13.44 82 24030 105890 90498445
Swelling 33.80 13.44 37 24075 419021 90185314
Alopecia 33.42 13.44 50 24062 495021 90109314
Atrial fibrillation 33.03 13.44 94 24018 133517 90470818
Disorientation 32.79 13.44 49 24063 44065 90560270
Oedema peripheral 32.22 13.44 145 23967 257770 90346565
Vitamin D decreased 31.77 13.44 26 24086 11953 90592382
Pain of skin 30.79 13.44 29 24083 16053 90588282
Rheumatoid arthritis 30.37 13.44 31 24081 362583 90241752
Sinusitis 30.28 13.44 28 24084 343060 90261275
Musculoskeletal stiffness 30.17 13.44 21 24091 296511 90307824
Anaemia 29.92 13.44 178 23934 352624 90251711
Facial pain 29.60 13.44 26 24086 13156 90591179
Blood pressure decreased 29.48 13.44 63 24049 74832 90529503
Hypertensive encephalopathy 29.28 13.44 10 24102 745 90603590
Oesophagitis 29.07 13.44 29 24083 17220 90587115
Subarachnoid haemorrhage 28.16 13.44 29 24083 17875 90586460
Blood potassium increased 28.03 13.44 31 24081 20718 90583617
Liver injury 27.27 13.44 6 24106 170561 90433774
Blood cholesterol increased 26.61 13.44 11 24101 208001 90396334
Off label use 26.17 13.44 179 23933 1102073 89502262
Stomatitis 25.95 13.44 21 24091 274677 90329658
Loss of personal independence in daily activities 25.76 13.44 3 24109 136102 90468233
Vision blurred 25.72 13.44 76 24036 110217 90494118
Feeling cold 25.60 13.44 34 24078 27431 90576904
Bradyphrenia 25.57 13.44 19 24093 7593 90596742
Therapeutic product effect incomplete 25.22 13.44 10 24102 193886 90410449
Mucosal membrane hyperplasia 24.86 13.44 5 24107 43 90604292
Blood pressure diastolic decreased 24.68 13.44 33 24079 26793 90577542
Bursitis 24.68 13.44 3 24109 131651 90472684
Maternal exposure during pregnancy 24.64 13.44 36 24076 360027 90244308
Condition aggravated 24.60 13.44 79 24033 595466 90008869
Swollen tongue 24.59 13.44 44 24068 45912 90558423
Blood glucose increased 24.50 13.44 68 24044 95178 90509157
Subdural haematoma 24.46 13.44 26 24086 16619 90587716
Crush syndrome 24.19 13.44 7 24105 302 90604033
Pain 24.03 13.44 161 23951 996180 89608155
Serotonin syndrome 23.87 13.44 39 24073 37848 90566487
Blood uric acid abnormal 23.66 13.44 6 24106 156 90604179
Palpitations 23.57 13.44 85 24027 136643 90467692
Chronic kidney disease 23.04 13.44 45 24067 50146 90554189
Haematoma 23.00 13.44 39 24073 39009 90565326
Gastrointestinal disorder 22.57 13.44 21 24091 256666 90347669
Eye infarction 22.44 13.44 5 24107 73 90604262
Urine glucose/creatinine ratio increased 22.35 13.44 6 24106 196 90604139
Renin increased 22.20 13.44 6 24106 201 90604134
Confusional state 22.13 13.44 177 23935 386028 90218307
Hypomagnesaemia 21.56 13.44 36 24076 35552 90568783
Vertebrobasilar insufficiency 21.50 13.44 6 24106 227 90604108
Lethargy 21.36 13.44 50 24062 63089 90541246
Abdominal discomfort 21.36 13.44 61 24051 477267 90127068
Nasopharyngitis 21.32 13.44 48 24064 407056 90197279
Malignant hypertension 21.32 13.44 9 24103 1198 90603137
Eye pruritus 21.23 13.44 32 24080 28995 90575340
Daydreaming 21.17 13.44 7 24105 472 90603863
Post cardiac arrest syndrome 21.15 13.44 4 24108 24 90604311
Osteoarthritis 21.07 13.44 13 24099 195717 90408618
Clonus 20.78 13.44 15 24097 5735 90598600
Hypocalcaemia 20.70 13.44 39 24073 42329 90562006
Wrong patient 20.69 13.44 8 24104 849 90603486
Pemphigoid 20.66 13.44 18 24094 9008 90595327
Pericarditis 20.52 13.44 25 24087 270126 90334209
Infection 20.38 13.44 41 24071 362053 90242282
Wheezing 20.33 13.44 20 24092 238060 90366275
Product use in unapproved indication 19.85 13.44 37 24075 336199 90268136
Blood pressure systolic abnormal 19.53 13.44 25 24087 19453 90584882
Ophthalmic herpes zoster 19.41 13.44 11 24101 2777 90601558
Hallucination, visual 19.12 13.44 27 24085 23065 90581270
Fall 19.09 13.44 204 23908 481606 90122729
Cerebral infarction 18.99 13.44 29 24083 26567 90577768
Circulatory collapse 18.99 13.44 28 24084 24876 90579459
Hallucination 18.89 13.44 49 24063 65910 90538425
Use of accessory respiratory muscles 18.87 13.44 6 24106 357 90603978
Hyperreflexia 18.82 13.44 15 24097 6642 90597693
Oral discharge 18.69 13.44 5 24107 161 90604174
Thrombotic microangiopathy 18.69 13.44 22 24090 15721 90588614
Hypersensitivity 18.28 13.44 61 24051 454616 90149719
Exposure during pregnancy 18.17 13.44 22 24090 238388 90365947
Incontinence 18.02 13.44 20 24092 13415 90590920
Nephrogenic systemic fibrosis 17.85 13.44 12 24100 4096 90600239
Dyspnoea 17.83 13.44 331 23781 880624 89723711
Heart rate decreased 17.69 13.44 42 24070 53463 90550872
Renal atrophy 17.66 13.44 9 24103 1839 90602496
Joint range of motion decreased 17.63 13.44 7 24105 135636 90468699
Blindness 17.62 13.44 28 24084 26540 90577795
Blood pressure diastolic abnormal 17.59 13.44 24 24088 19857 90584478
Torticollis 17.56 13.44 10 24102 2548 90601787
Angiosclerosis 17.54 13.44 3 24109 9 90604326
Lung disorder 17.50 13.44 9 24103 149874 90454461
Renal salt-wasting syndrome 17.49 13.44 6 24106 453 90603882
Hyperhidrosis 17.28 13.44 77 24035 136228 90468107
Feeling abnormal 17.24 13.44 89 24023 167146 90437189
Jaundice 17.23 13.44 31 24081 32486 90571849
Azotaemia 17.19 13.44 13 24099 5335 90599000
Anaphylactoid reaction 16.94 13.44 12 24100 4456 90599879
Gait inability 16.80 13.44 9 24103 146447 90457888
Road traffic accident 16.77 13.44 4 24108 107622 90496713
Product monitoring error 16.75 13.44 12 24100 4532 90599803
Renal tubular necrosis 16.72 13.44 20 24092 14535 90589800
Tinnitus 16.66 13.44 36 24076 43066 90561269
Drug ineffective 16.63 13.44 264 23848 1384034 89220301
Vomiting 16.57 13.44 298 23814 787995 89816340
Prescribed overdose 16.51 13.44 3 24109 97622 90506713
Inflammation 16.43 13.44 14 24098 178578 90425757
Injury 16.36 13.44 17 24095 197332 90407003
Cognitive disorder 16.34 13.44 48 24064 69359 90534976
Gingival bleeding 16.34 13.44 20 24092 14883 90589452
Lower respiratory tract infection 16.23 13.44 26 24086 250633 90353702
Blood pressure fluctuation 16.11 13.44 40 24072 52373 90551962
Fasting 15.59 13.44 3 24109 20 90604315
End stage renal disease 15.54 13.44 15 24097 8556 90595779
Nephrotic syndrome 15.53 13.44 14 24098 7325 90597010
Urticaria 15.47 13.44 38 24074 312696 90291639
Limb injury 15.38 13.44 29 24083 31479 90572856
Adverse event 15.35 13.44 6 24106 117412 90486923
Post procedural hypotension 15.34 13.44 3 24109 22 90604313
Aortic stenosis 15.24 13.44 13 24099 6323 90598012
Swelling face 15.24 13.44 52 24060 81300 90523035
Nephrogenic anaemia 15.23 13.44 9 24103 2457 90601878
Metabolic myopathy 15.10 13.44 4 24108 124 90604211
Product residue present 15.06 13.44 11 24101 4280 90600055
Plasmapheresis 14.97 13.44 5 24107 348 90603987
Drug dispensed to wrong patient 14.89 13.44 5 24107 354 90603981
Weight increased 14.86 13.44 59 24053 417868 90186467
Anuria 14.83 13.44 19 24093 14799 90589536
Liver function test abnormal 14.79 13.44 38 24074 50807 90553528
Simple partial seizures 14.74 13.44 6 24106 729 90603606
Shock 14.69 13.44 27 24085 28751 90575584
Wound infection 14.65 13.44 5 24107 106397 90497938
Scrotal oedema 14.51 13.44 3 24109 30 90604305
Blood pressure systolic increased 14.36 13.44 41 24071 58304 90546031
Sleep disorder 14.33 13.44 19 24093 198011 90406324
Malaise 14.30 13.44 227 23885 585759 90018576
Duodenal ulcer 14.18 13.44 15 24097 9537 90594798
Electrocardiogram ST-T segment abnormal 13.88 13.44 5 24107 436 90603899
Familial periodic paralysis 13.82 13.44 4 24108 173 90604162
Gastrointestinal haemorrhage 13.80 13.44 54 24058 90194 90514141
Mobility decreased 13.58 13.44 29 24083 250705 90353630
Left ventricular hypertrophy 13.56 13.44 12 24100 6132 90598203
Polyuria 13.56 13.44 15 24097 10025 90594310

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Conjunctivitis allergic 276.59 11.66 133 46203 5778 42569221
Mycotic allergy 268.84 11.66 123 46213 4768 42570231
Mite allergy 268.29 11.66 124 46212 4922 42570077
Spirometry abnormal 265.96 11.66 124 46212 5022 42569977
Dust allergy 264.83 11.66 125 46211 5207 42569792
Normochromic normocytic anaemia 223.60 11.66 133 46203 8898 42566101
Arteriosclerosis 219.59 11.66 171 46165 17818 42557181
Asthma 184.14 11.66 279 46057 62035 42512964
Syncope 183.17 11.66 361 45975 99045 42475954
Arteriosclerosis coronary artery 174.47 11.66 152 46184 18525 42556474
Neuritis 170.87 11.66 98 46238 6122 42568877
Pulmonary vasculitis 167.53 11.66 97 46239 6169 42568830
Full blood count abnormal 164.38 11.66 182 46154 29694 42545305
Nodule 159.18 11.66 122 46214 12412 42562587
Off label use 150.09 11.66 293 46043 638042 41936957
Productive cough 138.51 11.66 221 46115 51346 42523653
Eosinophilic granulomatosis with polyangiitis 136.64 11.66 96 46240 8542 42566457
Neurological symptom 135.17 11.66 101 46235 9890 42565109
Sleep disorder due to a general medical condition 129.75 11.66 125 46211 17328 42557671
Obstructive airways disorder 119.55 11.66 141 46195 24618 42550381
Carotid arteriosclerosis 113.73 11.66 54 46282 2278 42572721
Wheezing 113.18 11.66 209 46127 54572 42520427
Respiratory symptom 113.12 11.66 95 46241 11011 42563988
Antineutrophil cytoplasmic antibody positive 112.53 11.66 66 46270 4299 42570700
Hypertensive crisis 109.56 11.66 90 46246 10116 42564883
Total lung capacity abnormal 108.84 11.66 65 46271 4378 42570621
Pulmonary alveolar haemorrhage 106.16 11.66 104 46232 14712 42560287
Orthostatic hypotension 101.98 11.66 145 46191 30425 42544574
Pulmonary fibrosis 85.25 11.66 124 46212 26557 42548442
Forced expiratory volume decreased 79.22 11.66 66 46270 7564 42567435
Capillaritis 77.42 11.66 41 46295 2187 42572812
Febrile neutropenia 70.53 11.66 59 46277 185644 42389355
Neutropenia 69.05 11.66 69 46267 199362 42375637
Thrombosis 68.28 11.66 196 46140 68315 42506684
Drug ineffective 67.01 11.66 407 45929 629790 41945209
Hypothyroidism 66.98 11.66 123 46213 31961 42543038
Renal cyst haemorrhage 66.94 11.66 26 46310 664 42574335
Vasculitis 66.94 11.66 91 46245 18303 42556696
Hyperkalaemia 66.91 11.66 216 46120 80242 42494757
Left ventricular hypertrophy 65.98 11.66 65 46271 9254 42565745
Blood pressure inadequately controlled 65.20 11.66 40 46296 2828 42572171
Presyncope 62.90 11.66 98 46238 22289 42552710
Haemoptysis 62.34 11.66 148 46188 46019 42528980
Rectal prolapse 57.23 11.66 22 46314 546 42574453
Loss of consciousness 57.13 11.66 225 46111 92129 42482870
Hypoxia 56.80 11.66 186 46150 69600 42505399
Drug abuse 55.82 11.66 22 46314 104749 42470250
Hypotension 54.82 11.66 472 45864 257159 42317840
Aortic valve incompetence 54.60 11.66 50 46286 6498 42568501
Primary hyperaldosteronism 53.97 11.66 16 46320 172 42574827
Dizziness 50.08 11.66 451 45885 248803 42326196
Oedema peripheral 50.02 11.66 285 46051 135791 42439208
Renal artery stenosis 49.34 11.66 31 46305 2286 42572713
Complications of transplanted kidney 48.85 11.66 43 46293 5307 42569692
Drug interaction 47.61 11.66 471 45865 266528 42308471
Middle insomnia 47.04 11.66 50 46286 7783 42567216
Aortic dilatation 42.40 11.66 25 46311 1644 42573355
SARS-CoV-2 antibody test positive 41.97 11.66 16 46320 388 42574611
Lung disorder 41.95 11.66 131 46205 47792 42527207
Abdominal wall haemorrhage 41.49 11.66 17 46319 501 42574498
Vena cava injury 40.75 11.66 15 46321 329 42574670
Product dose omission issue 40.34 11.66 66 46270 154299 42420700
Foetal exposure during pregnancy 39.94 11.66 3 46333 47308 42527691
Gastrointestinal tract mucosal pigmentation 39.67 11.66 17 46319 562 42574437
Vascular compression 38.77 11.66 15 46321 379 42574620
Vascular anastomotic haemorrhage 38.38 11.66 14 46322 299 42574700
Nephrectomy 38.20 11.66 19 46317 888 42574111
Disease progression 37.93 11.66 61 46275 143595 42431404
Hyperparathyroidism secondary 37.62 11.66 24 46312 1818 42573181
Blood creatinine increased 37.55 11.66 226 46110 109777 42465222
Bradycardia 37.49 11.66 188 46148 85296 42489703
Mucosal inflammation 36.84 11.66 5 46331 49369 42525630
Metabolic acidosis 36.74 11.66 132 46204 51726 42523273
Mycobacterium test positive 36.02 11.66 15 46321 461 42574538
Product use in unapproved indication 35.43 11.66 94 46242 184362 42390637
Aortic arteriosclerosis 34.93 11.66 35 46301 5085 42569914
Ventricular hyperkinesia 34.30 11.66 12 46324 226 42574773
Thrombocytopenia 34.30 11.66 100 46236 190179 42384820
Loss of personal independence in daily activities 33.76 11.66 125 46211 49691 42525308
Sepsis 33.62 11.66 108 46228 199226 42375773
Blood 25-hydroxycholecalciferol decreased 33.54 11.66 13 46323 330 42574669
Tricuspid valve incompetence 33.11 11.66 50 46286 11063 42563936
Hypertensive heart disease 32.50 11.66 25 46311 2555 42572444
Renal impairment 32.39 11.66 218 46118 110010 42464989
Right atrial enlargement 32.07 11.66 12 46324 276 42574723
Delayed graft function 32.03 11.66 25 46311 2610 42572389
Septic shock 31.36 11.66 32 46304 91640 42483359
Atrial fibrillation 31.33 11.66 259 46077 139334 42435665
Death 31.19 11.66 345 45991 470840 42104159
Inappropriate schedule of product administration 31.11 11.66 35 46301 95867 42479132
Hypochromasia 30.45 11.66 12 46324 319 42574680
Perineal cyst 30.11 11.66 11 46325 236 42574763
Multiple organ dysfunction syndrome 29.78 11.66 37 46299 96998 42478001
Drug ineffective for unapproved indication 29.42 11.66 7 46329 46156 42528843
Lipoprotein (a) increased 29.34 11.66 12 46324 352 42574647
Mitral valve thickening 29.32 11.66 13 46323 467 42574532
Biliary cirrhosis 29.06 11.66 10 46326 179 42574820
Intraductal papillary mucinous neoplasm 29.04 11.66 13 46323 478 42574521
Blood pressure increased 29.00 11.66 200 46136 101728 42473271
Therapeutic product effect incomplete 28.31 11.66 152 46184 70787 42504212
Pyrexia 28.29 11.66 283 46053 393759 42181240
Atrioventricular block first degree 28.11 11.66 35 46301 6456 42568543
Orthopnoea 28.06 11.66 32 46304 5385 42569614
Hypokalaemia 27.50 11.66 152 46184 71569 42503430
Angioedema 27.47 11.66 105 46231 42372 42532627
Pain in extremity 27.42 11.66 267 46069 150337 42424662
Lung diffusion test decreased 27.26 11.66 15 46321 864 42574135
Myocardial infarction 27.24 11.66 229 46107 123780 42451219
Floppy iris syndrome 27.21 11.66 11 46325 313 42574686
Melaena 26.91 11.66 98 46238 38648 42536351
Hyperparathyroidism 26.71 11.66 17 46319 1282 42573717
Tongue haemorrhage 26.60 11.66 14 46322 737 42574262
Haemodialysis 26.19 11.66 43 46293 10217 42564782
Subacute hepatic failure 26.19 11.66 8 46328 96 42574903
Product use issue 26.01 11.66 27 46309 76724 42498275
Electrocardiogram T wave inversion 25.92 11.66 21 46315 2313 42572686
Mean platelet volume increased 25.68 11.66 13 46323 631 42574368
Blood potassium increased 25.63 11.66 60 46276 18476 42556523
Urine flow decreased 25.63 11.66 17 46319 1376 42573623
Renal cyst 25.53 11.66 42 46294 9997 42565002
Atrioventricular block 25.50 11.66 41 46295 9574 42565425
Left ventricular enlargement 25.26 11.66 14 46322 818 42574181
Large intestine polyp 25.25 11.66 40 46296 9225 42565774
Scrotal oedema 25.24 11.66 19 46317 1880 42573119
Vertigo 24.81 11.66 88 46248 34259 42540740
Dyspnoea 24.58 11.66 642 45694 441979 42133020
Renin increased 24.30 11.66 9 46327 201 42574798
Myopathy 24.11 11.66 49 46287 13712 42561287
Cardiac autonomic neuropathy 24.07 11.66 7 46329 70 42574929
Erosive duodenitis 24 11.66 18 46318 1771 42573228
Blood pressure ambulatory increased 23.98 11.66 7 46329 71 42574928
Mitral valve incompetence 23.49 11.66 54 46282 16435 42558564
Spinal osteoarthritis 22.98 11.66 37 46299 8649 42566350
Diverticulum intestinal 22.84 11.66 28 46308 5085 42569914
Left atrial enlargement 22.42 11.66 14 46322 1021 42573978
Nocturia 22.26 11.66 44 46292 12068 42562931
Blood urea increased 21.98 11.66 82 46254 32711 42542288
Phaeochromocytoma 21.82 11.66 9 46327 270 42574729
Malignant neoplasm progression 21.75 11.66 54 46282 108346 42466653
Mean cell volume increased 21.73 11.66 24 46312 3899 42571100
Gravitational oedema 21.73 11.66 12 46324 696 42574303
Chronic kidney disease 21.48 11.66 105 46231 47136 42527863
Treatment failure 21.25 11.66 22 46314 62602 42512397
Adrenal cyst 21.22 11.66 8 46328 188 42574811
Nausea 21.17 11.66 304 46032 396495 42178504
Intervertebral disc space narrowing 21.13 11.66 14 46322 1131 42573868
Endoscopy upper gastrointestinal tract abnormal 21.10 11.66 6 46330 55 42574944
Angina pectoris 21.01 11.66 81 46255 32815 42542184
Actinic keratosis 20.98 11.66 27 46309 5149 42569850
Hypergastrinaemia 20.11 11.66 8 46328 218 42574781
Sprue-like enteropathy 19.95 11.66 11 46325 636 42574363
Infusion related reaction 19.92 11.66 22 46314 60784 42514215
Pain 19.61 11.66 171 46165 244677 42330322
Leukopenia 19.47 11.66 32 46304 74714 42500285
Intentional product use issue 19.42 11.66 30 46306 71803 42503196
Infection 19.38 11.66 60 46276 112008 42462991
Hepatic cytolysis 19.37 11.66 3 46333 26841 42548158
Spinal stenosis 19.34 11.66 29 46307 6377 42568622
Tooth avulsion 19.29 11.66 5 46331 31 42574968
Supine hypertension 19.03 11.66 9 46327 376 42574623
Shock hypoglycaemic 18.80 11.66 6 46330 84 42574915
Paraganglion neoplasm 18.60 11.66 4 46332 9 42574990
Glomerular filtration rate decreased 18.47 11.66 49 46287 16302 42558697
Agitation 18.22 11.66 26 46310 64288 42510711
Toxic neuropathy 18.03 11.66 10 46326 585 42574414
Duplicate therapy error 18.03 11.66 8 46328 288 42574711
CADASIL 17.89 11.66 6 46330 99 42574900
Bundle branch block left 17.70 11.66 28 46308 6448 42568551
Renal failure 17.64 11.66 236 46100 143490 42431509
Drug dependence 17.41 11.66 5 46331 29089 42545910
Rhabdomyolysis 17.08 11.66 144 46192 77875 42497124
Acute kidney injury 17.05 11.66 521 45815 366816 42208183
Glycosylated haemoglobin increased 16.97 11.66 41 46295 12883 42562116
Bursitis infective 16.95 11.66 10 46326 658 42574341
Hepatosplenomegaly 16.87 11.66 23 46313 4637 42570362
Device related bacteraemia 16.80 11.66 10 46326 669 42574330
Hypertension 16.74 11.66 265 46071 166939 42408060
Blood chloride increased 16.74 11.66 20 46316 3536 42571463
Dilatation ventricular 16.52 11.66 17 46319 2549 42572450
Pneumonia 16.50 11.66 342 45994 421807 42153192
Completed suicide 16.43 11.66 52 46284 96413 42478586
Myalgia 16.33 11.66 168 46168 95912 42479087
Myopathy toxic 15.99 11.66 10 46326 731 42574268
Respiratory failure 15.53 11.66 79 46257 128053 42446946
Swelling of eyelid 15.36 11.66 15 46321 2113 42572886
Xanthopsia 15.28 11.66 6 46330 158 42574841
Neuropathy peripheral 15.25 11.66 58 46278 101795 42473204
Toxic optic neuropathy 15.16 11.66 11 46325 1029 42573970
Spermatozoa progressive motility abnormal 14.77 11.66 4 46332 30 42574969
Pancytopenia 14.61 11.66 72 46264 117671 42457328
Microalbuminuria 14.49 11.66 10 46326 864 42574135
Vitamin D decreased 14.44 11.66 21 46315 4494 42570505
Kidney transplant rejection 14.13 11.66 30 46306 8653 42566346
Circulatory collapse 14.12 11.66 57 46279 23579 42551420
Clang associations 14.03 11.66 4 46332 37 42574962
Haematuria 13.90 11.66 109 46227 57690 42517309
Obstruction 13.87 11.66 17 46319 3086 42571913
Chronic fatigue syndrome 13.84 11.66 7 46329 339 42574660
Toxicity to various agents 13.84 11.66 171 46165 228965 42346034
Premature baby 13.82 11.66 4 46332 23149 42551850
Nephrogenic systemic fibrosis 13.78 11.66 18 46318 3483 42571516
High density lipoprotein decreased 13.75 11.66 19 46317 3878 42571121
Psoriatic arthropathy 13.69 11.66 5 46331 24962 42550037
Pulmonary embolism 13.69 11.66 194 46142 119418 42455581
Optic nerve disorder 13.67 11.66 9 46327 719 42574280
Blood potassium abnormal 13.66 11.66 13 46323 1773 42573226
Stomatitis 13.62 11.66 21 46315 50308 42524691
Benign prostatic hyperplasia 13.57 11.66 52 46284 21000 42553999
Anuria 13.48 11.66 35 46301 11497 42563502
Inappropriate affect 13.36 11.66 9 46327 747 42574252
Erectile dysfunction 13.26 11.66 58 46278 24855 42550144
Transaminases increased 13.02 11.66 10 46326 32875 42542124
Nephrogenic anaemia 12.93 11.66 15 46321 2571 42572428
Dermatosis 12.92 11.66 7 46329 391 42574608
Haemoglobin decreased 12.90 11.66 209 46127 132262 42442737
White blood cell count decreased 12.85 11.66 69 46267 110327 42464672
Coronary artery disease 12.75 11.66 101 46235 53619 42521380
Urinary retention 12.69 11.66 84 46252 42130 42532869
Cerebral haemorrhage 12.61 11.66 79 46257 38887 42536112
Hypochromic anaemia 12.60 11.66 10 46326 1070 42573929
Genital swelling 12.53 11.66 6 46330 258 42574741
Hyperuricaemia 12.48 11.66 30 46306 9394 42565605
Diastolic dysfunction 12.39 11.66 25 46311 6958 42568041
Lymphopenia 12.37 11.66 4 46332 21559 42553440
Prostatic haemorrhage 12.32 11.66 6 46330 268 42574731
Intentional product misuse 12.28 11.66 31 46305 61869 42513130
Arteriovenous fistula operation 12.28 11.66 5 46331 145 42574854
Jaundice hepatocellular 12.28 11.66 4 46332 60 42574939
Bronchopulmonary aspergillosis 12.27 11.66 3 46333 19426 42555573
Ventricular extrasystoles 12.08 11.66 37 46299 13353 42561646
Drug reaction with eosinophilia and systemic symptoms 11.92 11.66 17 46319 42058 42532941
Drug intolerance 11.91 11.66 46 46290 80378 42494621
Rash maculo-papular 11.81 11.66 14 46322 37489 42537510
Drug monitoring procedure not performed 11.72 11.66 7 46329 471 42574528
Visual field defect 11.68 11.66 20 46316 4918 42570081

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Syncope 385.19 11.55 523 62316 202013 110324447
Conjunctivitis allergic 342.70 11.55 134 62705 6797 110519663
Spirometry abnormal 339.41 11.55 125 62714 5372 110521088
Mite allergy 332.81 11.55 125 62714 5678 110520782
Dust allergy 332.34 11.55 126 62713 5875 110520585
Mycotic allergy 326.08 11.55 124 62715 5830 110520630
Normochromic normocytic anaemia 267.12 11.55 136 62703 12921 110513539
Arteriosclerosis 265.34 11.55 169 62670 24598 110501862
Hyperkalaemia 263.05 11.55 354 62485 135442 110391018
Hypertensive crisis 243.09 11.55 159 62680 24213 110502247
Arteriosclerosis coronary artery 229.12 11.55 155 62684 24963 110501497
Pulmonary vasculitis 226.18 11.55 98 62741 6462 110519998
Neuritis 221.19 11.55 100 62739 7299 110519161
Hypotension 216.85 11.55 722 62117 523127 110003333
Drug interaction 201.32 11.55 683 62156 499500 110026960
Orthostatic hypotension 178.61 11.55 204 62635 66045 110460415
Eosinophilic granulomatosis with polyangiitis 177.93 11.55 97 62742 10589 110515871
Full blood count abnormal 177.82 11.55 188 62651 55864 110470596
Neurological symptom 160.97 11.55 104 62735 15504 110510956
Acute kidney injury 156.87 11.55 745 62094 634685 109891775
Total lung capacity abnormal 149.98 11.55 66 62773 4517 110521943
Antineutrophil cytoplasmic antibody positive 146.66 11.55 67 62772 5009 110521451
Respiratory symptom 145.37 11.55 96 62743 14849 110511611
Productive cough 141.51 11.55 242 62597 114063 110412397
Pulmonary alveolar haemorrhage 139.20 11.55 105 62734 20045 110506415
Obstructive airways disorder 136.20 11.55 149 62690 46000 110480460
Off label use 131.00 11.55 428 62411 1499757 109026703
Nodule 128.37 11.55 123 62716 32508 110493952
Bradycardia 122.45 11.55 272 62567 155245 110371215
Renal impairment 121.65 11.55 305 62534 188140 110338320
Vasculitis 120.36 11.55 124 62715 35749 110490711
Presyncope 117.56 11.55 142 62697 48745 110477715
Hyponatraemia 116.91 11.55 329 62510 217324 110309136
Rectal prolapse 107.43 11.55 44 62795 2519 110523941
Loss of consciousness 104.69 11.55 296 62543 196010 110330450
Metabolic acidosis 102.78 11.55 195 62644 99549 110426911
Renal artery stenosis 100.84 11.55 47 62792 3679 110522781
Carotid arteriosclerosis 99.96 11.55 44 62795 3013 110523447
Capillaritis 99.28 11.55 41 62798 2398 110524062
Drug intolerance 98.76 11.55 54 62785 406458 110120002
Systemic lupus erythematosus 97.98 11.55 14 62825 254324 110272136
Psoriatic arthropathy 94.57 11.55 4 62835 196757 110329703
Pemphigus 92.24 11.55 8 62831 214562 110311898
Alopecia 92.22 11.55 46 62793 364707 110161753
Glossodynia 90.91 11.55 10 62829 221994 110304466
Blood creatinine increased 90.03 11.55 268 62571 182621 110343839
Hepatic enzyme increased 89.74 11.55 35 62804 320857 110205603
Forced expiratory volume decreased 89.55 11.55 68 62771 13108 110513352
Angioedema 87.53 11.55 181 62658 98319 110428141
Pain 86.17 11.55 268 62571 954687 109571773
Sleep disorder due to a general medical condition 86.15 11.55 126 62713 51986 110474474
Arthropathy 86.13 11.55 28 62811 287494 110238966
Contraindicated product administered 86.13 11.55 18 62821 248249 110278211
Thrombosis 85.44 11.55 190 62649 108472 110417988
Renal failure 85.33 11.55 303 62536 226271 110300189
Infusion related reaction 85.04 11.55 56 62783 381106 110145354
Left ventricular hypertrophy 84.86 11.55 66 62773 13178 110513282
Duodenal ulcer perforation 84.13 11.55 4 62835 177696 110348764
Treatment failure 83.04 11.55 27 62812 277207 110249253
Folliculitis 81.96 11.55 3 62836 167650 110358810
Renal cyst haemorrhage 80.95 11.55 26 62813 735 110525725
Atrial fibrillation 79.64 11.55 299 62540 229343 110297117
Haemoptysis 79.14 11.55 144 62695 71210 110455250
Helicobacter infection 77.58 11.55 7 62832 181870 110344590
Blood pressure inadequately controlled 76.59 11.55 50 62789 7583 110518877
Fibromyalgia 74.48 11.55 6 62833 170903 110355557
Dizziness 73.22 11.55 660 62179 697533 109828927
Product use issue 71.98 11.55 44 62795 311651 110214809
Rheumatoid arthritis 71.01 11.55 41 62798 299572 110226888
Blood pressure increased 70.99 11.55 313 62526 258060 110268400
Complications of transplanted kidney 70.43 11.55 47 62792 7395 110519065
Sinusitis 69.75 11.55 41 62798 296647 110229813
Hypothyroidism 69.57 11.55 138 62701 72761 110453699
Therapeutic product effect decreased 69.37 11.55 26 62813 244290 110282170
Oedema peripheral 69.31 11.55 369 62470 328291 110198169
Maternal exposure during pregnancy 67.70 11.55 30 62809 254853 110271607
Pericarditis 66.21 11.55 21 62818 219093 110307367
Hypoxia 64.86 11.55 191 62648 129324 110397136
Wound 64.82 11.55 26 62813 234411 110292049
Ill-defined disorder 64.37 11.55 7 62832 156846 110369614
Muscle injury 64.07 11.55 4 62835 140803 110385657
Stomatitis 64.01 11.55 37 62802 270205 110256255
Blood urea increased 63.61 11.55 113 62726 54844 110471616
Primary hyperaldosteronism 62.58 11.55 17 62822 263 110526197
Lip swelling 62.31 11.55 107 62732 50560 110475900
Drug ineffective 61.47 11.55 561 62278 1519979 109006481
Irritable bowel syndrome 61.03 11.55 10 62829 164205 110362255
Discomfort 60.70 11.55 23 62816 214684 110311776
Melaena 58.34 11.55 124 62715 68633 110457827
Glomerular filtration rate decreased 58.32 11.55 77 62762 28879 110497581
Aortic valve incompetence 58.24 11.55 49 62790 10932 110515528
Hypokalaemia 57.08 11.55 230 62609 182218 110344242
Bladder prolapse 54.52 11.55 23 62816 1419 110525041
Impaired healing 54.08 11.55 22 62817 196695 110329765
Cardiac failure 53.58 11.55 230 62609 187396 110339064
Hypoglycaemia 53.23 11.55 166 62673 115938 110410522
Nasopharyngitis 53.05 11.55 89 62750 394272 110132188
Rhabdomyolysis 52.33 11.55 169 62670 120232 110406228
SARS-CoV-2 antibody test positive 51.72 11.55 16 62823 399 110526061
Blood potassium increased 51.52 11.55 78 62761 33171 110493289
Infection 50.34 11.55 80 62759 362120 110164340
Musculoskeletal stiffness 50.10 11.55 51 62788 279771 110246689
Neutropenia 49.97 11.55 85 62754 374535 110151925
Vena cava injury 49.96 11.55 15 62824 337 110526123
Abdominal wall haemorrhage 49.74 11.55 18 62821 735 110525725
Renin increased 49.39 11.55 15 62824 351 110526109
Product use in unapproved indication 48.94 11.55 114 62725 447263 110079197
Sinus bradycardia 48.31 11.55 71 62768 29412 110497048
Bursitis 48.08 11.55 8 62831 129910 110396550
Scrotal oedema 47.97 11.55 22 62817 1659 110524801
Delayed graft function 47.96 11.55 30 62809 4227 110522233
Myocardial infarction 47.75 11.55 226 62613 191857 110334603
Vascular anastomotic haemorrhage 47.30 11.55 14 62825 299 110526161
Blood cholesterol increased 47.13 11.55 23 62816 184762 110341698
Febrile neutropenia 45.90 11.55 68 62771 316699 110209761
Chronic kidney disease 45.58 11.55 120 62719 76171 110450289
Middle insomnia 45.17 11.55 57 62782 20445 110506015
Aortic dilatation 44.79 11.55 23 62816 2223 110524237
Asthma 44.15 11.55 268 62571 250023 110276437
Mobility decreased 43.97 11.55 42 62797 237380 110289080
Dyspnoea 43.67 11.55 876 61963 1105996 109420464
Vitamin D decreased 42.37 11.55 43 62796 12172 110514288
Lip dry 42.27 11.55 4 62835 100079 110426381
Intentional product use issue 41.26 11.55 48 62791 247858 110278602
Mycobacterium test positive 41.14 11.55 15 62824 626 110525834
Hypersensitivity 41.00 11.55 107 62732 403891 110122569
Exposure during pregnancy 40.96 11.55 22 62817 167402 110359058
Sopor 40.82 11.55 74 62765 36472 110489988
Cerebral haemorrhage 40.67 11.55 104 62735 64864 110461596
Type 2 diabetes mellitus 39.54 11.55 26 62813 177206 110349254
Cardiac failure congestive 39.24 11.55 180 62659 150820 110375640
Abdominal discomfort 38.69 11.55 106 62733 393752 110132708
Product dose omission issue 38.48 11.55 78 62761 321704 110204756
Ventricular hyperkinesia 38.42 11.55 12 62827 309 110526151
Vascular compression 38.25 11.55 15 62824 766 110525694
Obesity 37.72 11.55 9 62830 113342 110413118
Blood 25-hydroxycholecalciferol decreased 37.62 11.55 13 62826 463 110525997
Gastrointestinal tract mucosal pigmentation 37.35 11.55 17 62822 1260 110525200
Perineal cyst 37.25 11.55 11 62828 233 110526227
Swelling 37.15 11.55 91 62748 350950 110175510
Gastrointestinal disorder 36.97 11.55 50 62789 241902 110284558
Erectile dysfunction 36.83 11.55 49 62790 18507 110507953
Mitral valve incompetence 36.61 11.55 67 62772 33262 110493198
Peripheral venous disease 36.51 11.55 3 62836 84114 110442346
Large intestine polyp 36.48 11.55 44 62795 15073 110511387
Hypertensive heart disease 36.37 11.55 26 62813 4570 110521890
Circulatory collapse 35.85 11.55 77 62762 42916 110483544
Tricuspid valve incompetence 35.57 11.55 55 62784 23818 110502642
Osteoarthritis 35.36 11.55 31 62808 182592 110343868
Benign prostatic hyperplasia 34.44 11.55 47 62792 18187 110508273
Grip strength decreased 34.41 11.55 3 62836 80171 110446289
Atrioventricular block 34.17 11.55 45 62794 16832 110509628
Gallbladder polyp 34.10 11.55 16 62823 1271 110525189
Hyperparathyroidism secondary 34.03 11.55 22 62817 3282 110523178
Atrioventricular block first degree 33.67 11.55 41 62798 14184 110512276
Nephrectomy 33.31 11.55 20 62819 2620 110523840
Left ventricular enlargement 33.29 11.55 14 62825 857 110525603
Erosive duodenitis 33.24 11.55 19 62820 2272 110524188
Orthopnoea 33.23 11.55 36 62803 10985 110515475
Renal cyst 33.06 11.55 46 62793 18126 110508334
Biliary cirrhosis 33.01 11.55 10 62829 232 110526228
Joint range of motion decreased 32.88 11.55 14 62825 121818 110404642
Right atrial enlargement 32.84 11.55 12 62827 504 110525956
Urine flow decreased 32.75 11.55 16 62823 1390 110525070
Lactic acidosis 32.26 11.55 121 62718 92690 110433770
Angina pectoris 32.26 11.55 93 62746 62202 110464258
Tubulointerstitial nephritis 32.03 11.55 85 62754 54199 110472261
Tongue haemorrhage 31.99 11.55 15 62824 1190 110525270
Urticaria 31.92 11.55 85 62754 318772 110207688
Aortic arteriosclerosis 31.71 11.55 35 62804 10903 110515557
Rash 31.67 11.55 306 62533 820658 109705802
Lower respiratory tract infection 31.63 11.55 56 62783 243050 110283410
Mitral valve thickening 31.55 11.55 13 62826 756 110525704
Wound infection 31.44 11.55 8 62831 96457 110430003
Haemoglobin decreased 30.65 11.55 244 62595 248483 110277977
Urinary incontinence 30.64 11.55 78 62761 48509 110477951
Intraductal papillary mucinous neoplasm 30.16 11.55 13 62826 846 110525614
Pulmonary fibrosis 29.81 11.55 126 62713 101916 110424544
Hyperuricaemia 29.81 11.55 39 62800 14492 110511968
Nocturia 29.42 11.55 42 62797 16948 110509512
Kidney transplant rejection 29.11 11.55 35 62804 11952 110514508
Hypochromasia 29.08 11.55 12 62827 700 110525760
Weight increased 28.48 11.55 132 62707 419512 110106948
Cardiac autonomic neuropathy 28.48 11.55 7 62832 71 110526389
Swollen tongue 28.30 11.55 87 62752 60275 110466185
Blister 28.14 11.55 54 62785 227322 110299138
Blood pressure ambulatory increased 28.13 11.55 7 62832 75 110526385
Night sweats 28.11 11.55 21 62818 133962 110392498
Haemodialysis 28.06 11.55 42 62797 17677 110508783
Injection site reaction 27.87 11.55 8 62831 89062 110437398
Anaemia 27.84 11.55 451 62388 546635 109979825
Sciatica 27.65 11.55 9 62830 92390 110434070
Lung diffusion test decreased 27.40 11.55 15 62824 1650 110524810
Hypomagnesaemia 27.37 11.55 86 62753 60284 110466176
Acute myocardial infarction 27.29 11.55 107 62732 83670 110442790
End stage renal disease 27.26 11.55 46 62793 21427 110505033
Phaeochromocytoma 27.10 11.55 12 62827 833 110525627
CADASIL 26.52 11.55 6 62833 41 110526419
Knee arthroplasty 26.39 11.55 3 62836 64945 110461515
Haematuria 26.22 11.55 105 62734 82900 110443560
Colitis ulcerative 26.02 11.55 6 62833 77357 110449103
Myalgia 25.70 11.55 215 62624 222166 110304294
Pulmonary embolism 25.66 11.55 209 62630 214265 110312195
Nephrogenic anaemia 25.47 11.55 21 62818 4556 110521904
Floppy iris syndrome 25.41 11.55 9 62830 345 110526115
Coronary artery disease 25.36 11.55 94 62745 71596 110454864
General physical health deterioration 25.32 11.55 140 62699 425155 110101305
Vertigo 25.17 11.55 107 62732 86763 110439697
Lower limb fracture 25.03 11.55 6 62833 75342 110451118
Actinic keratosis 24.90 11.55 25 62814 6988 110519472
Musculoskeletal pain 24.87 11.55 41 62798 182982 110343478
Subacute hepatic failure 24.81 11.55 8 62831 229 110526231
Inflammation 24.69 11.55 45 62794 193193 110333267
Subdural haematoma 24.54 11.55 60 62779 36394 110490066
Sprue-like enteropathy 24.43 11.55 14 62825 1682 110524778
Endoscopy upper gastrointestinal tract abnormal 24.31 11.55 6 62833 62 110526398
Autoimmune disorder 24.30 11.55 4 62835 65479 110460981
Left atrial enlargement 24.16 11.55 14 62825 1717 110524743
Adrenal cyst 23.99 11.55 8 62831 255 110526205
Thermal burn 23.92 11.55 26 62813 7962 110518498
Ischaemic cardiomyopathy 23.86 11.55 26 62813 7985 110518475
Prescribed overdose 23.73 11.55 10 62829 87571 110438889
Disease progression 23.71 11.55 66 62773 243968 110282492
Supine hypertension 23.29 11.55 9 62830 442 110526018
Hypertensive encephalopathy 22.99 11.55 12 62827 1199 110525261
Intervertebral disc space narrowing 22.98 11.55 14 62825 1882 110524578
Gravitational oedema 22.97 11.55 14 62825 1884 110524576
Proteinuria 22.94 11.55 62 62777 39956 110486504
Injection site inflammation 22.68 11.55 20 62819 4751 110521709
Wheezing 22.56 11.55 233 62606 254997 110271463
Mean platelet volume increased 22.46 11.55 13 62826 1591 110524869
Penile oedema 22.41 11.55 8 62831 314 110526146
Myopathy 22.32 11.55 46 62793 24914 110501546
Road traffic accident 22.31 11.55 17 62822 107381 110419079
Anuria 21.93 11.55 45 62794 24296 110502164
Glycosylated haemoglobin increased 21.67 11.55 44 62795 23575 110502885
Hypergastrinaemia 21.62 11.55 8 62831 348 110526112
Hepatosplenomegaly 21.56 11.55 23 62816 6896 110519564
Diabetic nephropathy 21.43 11.55 17 62822 3491 110522969
Obstruction 21.34 11.55 21 62818 5731 110520729
Hepatic cytolysis 21.26 11.55 3 62836 55050 110471410
Migraine 21.03 11.55 41 62798 171611 110354849
Blood glucose increased 20.94 11.55 138 62701 132358 110394102
Crush syndrome 20.81 11.55 8 62831 387 110526073
Blood pressure decreased 20.76 11.55 124 62715 114967 110411493
Arthralgia 20.72 11.55 315 62524 779317 109747143
Azotaemia 20.59 11.55 27 62812 10058 110516402
Ventricular extrasystoles 20.56 11.55 42 62797 22599 110503861
Dehydration 20.52 11.55 246 62593 279265 110247195
Angiosclerosis 20.36 11.55 4 62835 12 110526448
Diverticulum intestinal 20.33 11.55 29 62810 11690 110514770
Urinary retention 20.32 11.55 86 62753 69597 110456863
Hyperparathyroidism 20.20 11.55 17 62822 3793 110522667
Paraganglion neoplasm 20.14 11.55 5 62834 53 110526407
Mucosal membrane hyperplasia 20.06 11.55 5 62834 54 110526406
Cardiospasm 20.06 11.55 19 62820 4948 110521512
Duplicate therapy error 19.99 11.55 8 62831 431 110526029
Mean cell volume increased 19.70 11.55 24 62815 8306 110518154
Sinus node dysfunction 19.69 11.55 25 62814 9022 110517438
Transient ischaemic attack 19.47 11.55 80 62759 63902 110462558
Injection site erythema 19.45 11.55 15 62824 94161 110432299
Hip arthroplasty 19.44 11.55 4 62835 55809 110470651
Drug hypersensitivity 19.32 11.55 165 62674 453925 110072535
Fasting 19.28 11.55 5 62834 64 110526396
Pregnancy 19.22 11.55 3 62836 51064 110475396
Drug monitoring procedure not performed 19.21 11.55 11 62828 1319 110525141
Lower urinary tract symptoms 18.90 11.55 8 62831 498 110525962
Hypotensive crisis 18.53 11.55 6 62833 174 110526286
Nephrogenic systemic fibrosis 18.47 11.55 19 62820 5464 110520996
Psoriasis 18.43 11.55 32 62807 139961 110386499
Bundle branch block left 18.24 11.55 29 62810 12859 110513601
Coronary artery stenosis 18.17 11.55 30 62809 13728 110512732
Toxic neuropathy 18.16 11.55 10 62829 1113 110525347
Electrocardiogram T wave inversion 17.91 11.55 19 62820 5661 110520799
Spinal osteoarthritis 17.81 11.55 37 62802 20146 110506314
Blood chloride increased 17.80 11.55 20 62819 6352 110520108
Prostatic haemorrhage 17.80 11.55 6 62833 198 110526262
Electrocardiogram T wave peaked 17.60 11.55 10 62829 1182 110525278
Vertebrobasilar insufficiency 17.55 11.55 7 62832 374 110526086
Nausea 17.52 11.55 552 62287 1235138 109291322
Blood creatine phosphokinase increased 17.43 11.55 85 62754 72992 110453468
Priapism 17.42 11.55 19 62820 5842 110520618
Back injury 17.35 11.55 3 62836 47396 110479064
Spermatozoa progressive motility abnormal 17.35 11.55 4 62835 30 110526430
Device related bacteraemia 17.31 11.55 10 62829 1220 110525240
International normalised ratio increased 17.29 11.55 96 62743 86676 110439784
Gait inability 17.21 11.55 32 62807 136344 110390116
Hypocalcaemia 17.03 11.55 78 62761 65288 110461172
Drug ineffective for unapproved indication 17.00 11.55 20 62819 102818 110423642
Palmoplantar keratoderma 16.95 11.55 18 62821 5369 110521091
Atrioventricular block complete 16.78 11.55 36 62803 20046 110506414
Shock hypoglycaemic 16.72 11.55 6 62833 239 110526221
Cerebral infarction 16.71 11.55 66 62773 51772 110474688
Exostosis 16.63 11.55 3 62836 45953 110480507
Clang associations 16.61 11.55 4 62835 37 110526423
Toxic optic neuropathy 16.60 11.55 10 62829 1318 110525142
Head injury 16.57 11.55 58 62781 42959 110483501
Blood uric acid abnormal 16.48 11.55 7 62832 439 110526021
Prostatism 16.42 11.55 5 62834 118 110526342
Electrocardiogram ST segment elevation 16.38 11.55 23 62816 9137 110517323
Lethargy 16.35 11.55 100 62739 93476 110432984
Swelling face 16.35 11.55 99 62740 92222 110434238
Dermatosis 16.28 11.55 9 62830 1009 110525451
Chronic obstructive pulmonary disease 16.23 11.55 112 62727 109046 110417414
High density lipoprotein decreased 16.03 11.55 18 62821 5715 110520745
Renal tubular atrophy 16.03 11.55 12 62827 2264 110524196
Gastrointestinal haemorrhage 16.02 11.55 154 62685 165364 110361096
Liver function test increased 15.99 11.55 16 62823 88532 110437928
Oral discharge 15.82 11.55 6 62833 280 110526180
Muscle twitching 15.80 11.55 45 62794 29890 110496570
Product residue present 15.77 11.55 15 62824 3926 110522534
Pruritus genital 15.76 11.55 19 62820 6503 110519957
Post cardiac arrest syndrome 15.74 11.55 4 62835 47 110526413
Bursitis infective 15.62 11.55 10 62829 1466 110524994
Urine glucose/creatinine ratio increased 15.54 11.55 5 62834 142 110526318
Phaeochromocytoma crisis 15.53 11.55 7 62832 507 110525953
Venous thrombosis limb 15.53 11.55 17 62822 5248 110521212
Injection site pruritus 15.32 11.55 5 62834 51253 110475207
Acidosis 15.07 11.55 37 62802 22494 110503966
Joint swelling 15.02 11.55 170 62669 442675 110083785
Rectal haemorrhage 14.99 11.55 118 62721 119715 110406745
Bronchiolitis 14.94 11.55 17 62822 5476 110520984
Myelosuppression 14.91 11.55 19 62820 94321 110432139
Atrial tachycardia 14.89 11.55 22 62817 9156 110517304
Palpitations 14.85 11.55 147 62692 159065 110367395
Laryngitis 14.85 11.55 3 62836 42408 110484052
Cerebrovascular accident 14.84 11.55 163 62676 181121 110345339
Bradyphrenia 14.72 11.55 25 62814 11703 110514757
Fatigue 14.72 11.55 554 62285 1215404 109311056
Decreased ventricular preload 14.72 11.55 4 62835 62 110526398
Illness 14.67 11.55 15 62824 82156 110444304
Disorientation 14.63 11.55 79 62760 70592 110455868
Ventricular hypertrophy 14.60 11.55 19 62820 7026 110519434
Kidney fibrosis 14.40 11.55 15 62824 4377 110522083
Liver injury 14.37 11.55 41 62798 150372 110376088
Angina unstable 14.36 11.55 30 62809 16402 110510058
Septic shock 14.28 11.55 44 62795 157484 110368976
Tension headache 14.11 11.55 22 62817 9596 110516864
Herpes zoster 14.06 11.55 25 62814 108354 110418106
Sleep terror 13.96 11.55 18 62821 6592 110519868
Prescribed underdose 13.95 11.55 10 62829 65164 110461296
Asthenia 13.91 11.55 500 62339 688499 109837961
Swelling of eyelid 13.87 11.55 18 62821 6635 110519825
Injury 13.71 11.55 53 62786 177212 110349248
Tachyarrhythmia 13.69 11.55 20 62819 8241 110518219
Cardiomegaly 13.67 11.55 42 62797 29088 110497372
Mucosal inflammation 13.56 11.55 21 62818 96120 110430340
Epistaxis 13.47 11.55 123 62716 130249 110396211
Simple partial seizures 13.46 11.55 8 62831 1028 110525432
Genital swelling 13.38 11.55 6 62833 429 110526031
Aortic valve sclerosis 13.33 11.55 10 62829 1893 110524567
Sedation 13.28 11.55 12 62827 69671 110456789
Contusion 13.24 11.55 78 62761 233283 110293177
Haemophilus bacteraemia 13.13 11.55 5 62834 236 110526224
Drug dependence 13.09 11.55 6 62833 50014 110476446
Skin exfoliation 13.07 11.55 90 62749 87561 110438899
Ear pain 13.01 11.55 7 62832 53219 110473241
Blood uric acid increased 12.99 11.55 34 62805 21495 110504965
Hypoaesthesia 12.99 11.55 115 62724 314108 110212352
Muscular dystrophy 12.99 11.55 5 62834 243 110526217
Aortic dissection 12.96 11.55 15 62824 4918 110521542
Acquired apparent mineralocorticoid excess 12.88 11.55 4 62835 101 110526359
Oliguria 12.87 11.55 31 62808 18626 110507834
Carotid artery occlusion 12.82 11.55 21 62818 9544 110516916
Polyuria 12.80 11.55 30 62809 17708 110508752
Pemphigoid 12.80 11.55 32 62807 19675 110506785
Inappropriate schedule of product administration 12.68 11.55 66 62773 203571 110322889
Accelerated hypertension 12.62 11.55 7 62832 790 110525670
Shock 12.54 11.55 62 62777 53526 110472934
Tooth avulsion 12.52 11.55 4 62835 111 110526349
Product monitoring error 12.51 11.55 20 62819 8907 110517553
Blood pressure fluctuation 12.47 11.55 79 62760 74745 110451715
Hyperglycaemia 12.47 11.55 87 62752 85003 110441457
Pollakiuria 12.46 11.55 54 62785 44141 110482319
Feeling cold 12.38 11.55 45 62794 33942 110492518
Psychotic symptom 12.31 11.55 13 62826 3854 110522606
Malignant hypertension 12.29 11.55 9 62830 1642 110524818
Benign bone neoplasm 12.23 11.55 4 62835 120 110526340
Sepsis 12.17 11.55 123 62716 327223 110199237
Inappropriate affect 12.06 11.55 9 62830 1690 110524770
Visual field defect 12.03 11.55 21 62818 10051 110516409
Anaphylactoid reaction 12.00 11.55 17 62822 6809 110519651
Gastric ulcer haemorrhage 11.99 11.55 21 62818 10073 110516387
Mouth breathing 11.95 11.55 5 62834 302 110526158
Face oedema 11.93 11.55 44 62795 33425 110493035
Hyperlipidaemia 11.85 11.55 46 62793 35802 110490658
Periorbital oedema 11.85 11.55 21 62818 10171 110516289
Jaundice hepatocellular 11.84 11.55 4 62835 133 110526327
Ventricular tachycardia 11.81 11.55 58 62781 49951 110476509
Neuropathy peripheral 11.79 11.55 57 62782 179220 110347240
Blood glucose abnormal 11.78 11.55 24 62815 12892 110513568
Upper gastrointestinal haemorrhage 11.75 11.55 58 62781 50038 110476422
Dilatation ventricular 11.75 11.55 13 62826 4062 110522398
Anti-erythropoietin antibody negative 11.74 11.55 5 62834 316 110526144
Male sexual dysfunction 11.74 11.55 5 62834 316 110526144
Ejaculation disorder 11.70 11.55 6 62833 578 110525882
Metabolic myopathy 11.67 11.55 4 62835 139 110526321
Human polyomavirus infection 11.59 11.55 9 62830 1793 110524667
Nasal congestion 11.59 11.55 24 62815 98258 110428202
Bundle branch block 11.58 11.55 9 62830 1794 110524666
Pyrexia 11.58 11.55 406 62433 897859 109628601

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C02CA04 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
Alpha-adrenoreceptor antagonists
ATC G04CA55 GENITO URINARY SYSTEM AND SEX HORMONES
UROLOGICALS
DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
Alpha-adrenoreceptor antagonists
FDA MoA N0000000099 Adrenergic alpha-Antagonists
FDA EPC N0000175553 alpha-Adrenergic Blocker
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:37890 ฮฑ-adrenergic antagonist
CHEBI has role CHEBI:59844 antihyperplasia drug
CHEBI has role CHEBI:176497 geroprotector
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists

Related Drugs by ATC class:

C02CA Alpha-adrenoreceptor antagonists 4 drugs
indoraminprazosintrimazosinurapidil
G04CA Alpha-adrenoreceptor antagonists 8 drugs
alfuzosindutasteridefinasteridesilodosinsolifenacintadalafiltamsulosinterazosin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Benign prostatic hyperplasia indication 266569009
Priapism contraindication 6273006 DOID:9286
Stenosis of intestine contraindication 23065003
Orthostatic hypotension contraindication 28651003
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Cataract surgery contraindication 110473004
Disease of liver contraindication 235856003 DOID:409
Pyloric obstruction contraindication 244815007
Syncope contraindication 271594007
Intraoperative floppy iris syndrome contraindication 418801006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.22 Basic
pKa2 0.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 8.85 WOMBAT-PK CHEMBL
Alpha-1B adrenergic receptor GPCR ANTAGONIST Ki 9.10 WOMBAT-PK CHEMBL
Alpha-1A adrenergic receptor GPCR ANTAGONIST Ki 8.80 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.23 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 5 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.85 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 6.63 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.55 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.55 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 6.83 DRUG MATRIX
Interstitial collagenase Enzyme IC50 5.24 DRUG MATRIX
HLA class I histocompatibility antigen, A-3 alpha chain Surface antigen Kd 4.80 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.72 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 6.14 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 9.38 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 8.81 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.90 DRUG MATRIX

External reference:

IDSource
4019735 VUID
N0000147827 NUI
D00608 KEGG_DRUG
77883-43-3 SECONDARY_CAS_RN
4019565 VANDF
4019735 VANDF
C0114873 UMLSCUI
CHEBI:4708 CHEBI
CHEMBL707 ChEMBL_ID
CHEMBL1200561 ChEMBL_ID
D017292 MESH_DESCRIPTOR_UI
DB00590 DRUGBANK_ID
7170 IUPHAR_LIGAND_ID
5143 INN_ID
NW1291F1W8 UNII
3157 PUBCHEM_CID
39173 RXNORM
37806 MMSL
40546 MMSL
4637 MMSL
d00726 MMSL
003561 NDDF
004493 NDDF
108556006 SNOMEDCT_US
108557002 SNOMEDCT_US
372508002 SNOMEDCT_US
NW1291F1W8 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2410 TABLET 1 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2512 TABLET 2 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2614 TABLET 4 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2716 TABLET 8 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2750 TABLET 1 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2760 TABLET 2 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2770 TABLET 4 mg ORAL NDA 28 sections
Cardura HUMAN PRESCRIPTION DRUG LABEL 1 0049-2780 TABLET 8 mg ORAL NDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2067 TABLET 8 mg ORAL ANDA 26 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2068 TABLET 4 mg ORAL ANDA 26 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2069 TABLET 2 mg ORAL ANDA 26 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0093-2070 TABLET 1 mg ORAL ANDA 26 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-0356 TABLET 1 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-0356 TABLET 1 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-0357 TABLET 2 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-0357 TABLET 2 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-1358 TABLET 4 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-1358 TABLET 4 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-1359 TABLET 8 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0832-1359 TABLET 8 mg ORAL ANDA 28 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5522 TABLET 1 mg ORAL ANDA 18 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5523 TABLET 2 mg ORAL ANDA 18 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 0904-5524 TABLET 4 mg ORAL ANDA 18 sections
Doxazosin Mesylate HUMAN PRESCRIPTION DRUG LABEL 1 10544-292 TABLET 4 mg ORAL ANDA 24 sections
Doxazosin Mesylate HUMAN PRESCRIPTION DRUG LABEL 1 10544-629 TABLET 1 mg ORAL ANDA 24 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 16571-165 TABLET 1 mg ORAL ANDA 23 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 16571-166 TABLET 2 mg ORAL ANDA 23 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 16571-167 TABLET 4 mg ORAL ANDA 23 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 16571-168 TABLET 8 mg ORAL ANDA 23 sections
Doxazosin HUMAN PRESCRIPTION DRUG LABEL 1 16590-274 TABLET 4 mg ORAL ANDA 12 sections