doxazosin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihypertensive substances, prazosin derivatives	954	74191-85-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: doxazosin doxazosin mesylate doxazosine doxazosin mesilate	A prazosin-related compound that is a selective alpha-1-adrenergic blocker. Molecular weight: 451.48 Formula: C23H25N5O5 CLOGP: 3.58 LIPINSKI: 0 HAC: 10 HDO: 1 TPSA: 112.27 ALOGS: -2.76 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

doxazosin
doxazosin mesylate
doxazosine
doxazosin mesilate

A prazosin-related compound that is a selective alpha-1-adrenergic blocker.

Molecular weight: 451.48
Formula: C23H25N5O5
CLOGP: 3.58
LIPINSKI: 0
HAC: 10
HDO: 1
TPSA: 112.27
ALOGS: -2.76
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
4	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.59 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	1.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.60 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	10 hours	Lombardo F, Berellini G, Obach RS
BA (Bioavailability)	0.65 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

Date	Agency	Company	Orphan
Nov. 2, 1990	FDA	PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperkalaemia	153.78	13.22	130	19436	54073	63415383
Hypotension	146.96	13.22	284	19282	272320	63197136
Syncope	123.53	13.22	166	19400	117219	63352237
Hyponatraemia	118.89	13.22	159	19407	111741	63357715
Hypertensive crisis	110.40	13.22	65	19501	15221	63454235
Drug interaction	95.53	13.22	215	19351	228916	63240540
Acute kidney injury	91.28	13.22	230	19336	263185	63206271
Angioedema	69.98	13.22	80	19486	47885	63421571
Drug intolerance	62.78	13.22	10	19556	308651	63160805
Bladder prolapse	62.76	13.22	24	19542	2132	63467324
Renal impairment	58.76	13.22	101	19465	88254	63381202
Rectal prolapse	57.46	13.22	22	19544	1961	63467495
Bradycardia	55.80	13.22	89	19477	73138	63396318
Contraindicated product administered	54.86	13.22	3	19563	217645	63251811
Blood pressure increased	50.37	13.22	136	19430	161926	63307530
Arthropathy	49.12	13.22	7	19559	234785	63234671
Orthostatic hypotension	48.88	13.22	58	19508	36102	63433354
Hypoglycaemia	47.13	13.22	74	19492	59991	63409465
Treatment failure	46.51	13.22	4	19562	199039	63270417
Therapeutic product effect decreased	44.81	13.22	4	19562	193183	63276273
Gallbladder polyp	43.03	13.22	14	19552	773	63468683
Cardiospasm	40.80	13.22	17	19549	1890	63467566
Palmoplantar keratoderma	39.96	13.22	17	19549	1990	63467466
Glossodynia	38.19	13.22	5	19561	178871	63290585
Muscle twitching	37.84	13.22	38	19528	19630	63449826
Systemic lupus erythematosus	37.75	13.22	9	19557	208909	63260547
Injection site inflammation	37.72	13.22	20	19546	3823	63465633
Renal artery stenosis	37.44	13.22	16	19550	1893	63467563
Thermal burn	36.68	13.22	23	19543	6023	63463433
Atrial tachycardia	35.88	13.22	20	19546	4220	63465236
Sopor	35.80	13.22	39	19527	22125	63447331
Tubulointerstitial nephritis	35.65	13.22	37	19529	19866	63449590
Pruritus genital	35.41	13.22	17	19549	2637	63466819
Dizziness	35.38	13.22	240	19326	429685	63039771
Sleep terror	35.25	13.22	17	19549	2663	63466793
Sinus bradycardia	33.44	13.22	31	19535	14520	63454936
Presyncope	33.38	13.22	42	19524	27743	63441713
Vitamin D decreased	32.00	13.22	26	19540	10216	63459240
Product use issue	31.92	13.22	14	19552	220506	63248950
Urinary incontinence	31.68	13.22	44	19522	31970	63437486
Hepatic enzyme increased	30.64	13.22	12	19554	202316	63267140
Diplopia	30.32	13.22	37	19529	23691	63445765
Wrong patient	29.78	13.22	8	19558	225	63469231
Glomerular filtration rate decreased	29.66	13.22	28	19538	13413	63456043
Tension headache	29.64	13.22	19	19547	5167	63464289
Drug ineffective	29.10	13.22	196	19370	1044569	62424887
Renal failure	29.07	13.22	91	19475	117561	63351895
Carotid artery occlusion	28.83	13.22	18	19548	4676	63464780
Oedema peripheral	27.87	13.22	124	19442	189387	63280069
Blood pressure inadequately controlled	27.87	13.22	18	19548	4960	63464496
Confusional state	27.79	13.22	145	19421	236235	63233221
Blood potassium increased	27.47	13.22	31	19535	18278	63451178
Blood urea increased	27.22	13.22	37	19529	26342	63443114
Lactic acidosis	27.07	13.22	45	19521	38242	63431214
Maternal exposure during pregnancy	26.01	13.22	18	19548	220044	63249412
Cardiac failure	25.87	13.22	73	19493	89069	63380387
Blood creatinine increased	25.55	13.22	72	19494	87772	63381684
Feeling cold	25.40	13.22	34	19532	23854	63445602
Pain	25.32	13.22	130	19436	740498	62728958
Loss of consciousness	25.27	13.22	87	19479	118034	63351422
Blood pressure diastolic decreased	25.20	13.22	33	19533	22673	63446783
Cardiac failure congestive	25.18	13.22	74	19492	92359	63377097
Alopecia	24.95	13.22	41	19525	337495	63131961
Disorientation	24.78	13.22	44	19522	39408	63430048
Bradyphrenia	24.55	13.22	19	19547	6961	63462495
Eye infarction	24.45	13.22	5	19561	40	63469416
Mucosal membrane hyperplasia	24.13	13.22	5	19561	43	63469413
Ventricular tachycardia	23.68	13.22	30	19536	19949	63449507
Discomfort	23.63	13.22	11	19555	167363	63302093
Transient ischaemic attack	23.57	13.22	42	19524	37711	63431745
Immunisation	23.40	13.22	10	19556	1183	63468273
Swollen tongue	23.40	13.22	40	19526	34760	63434696
Off label use	23.26	13.22	118	19448	674344	62795112
Anosmia	22.67	13.22	18	19548	6842	63462614
Blood pressure decreased	22.66	13.22	57	19509	64965	63404491
Lip swelling	22.62	13.22	37	19529	31026	63438430
Vertebrobasilar insufficiency	22.46	13.22	6	19560	165	63469291
Blood pressure systolic abnormal	22.40	13.22	24	19542	13362	63456094
Daydreaming	22.07	13.22	7	19559	356	63469100
Metabolic acidosis	21.81	13.22	45	19521	45024	63424432
Renin increased	21.71	13.22	6	19560	188	63469268
Clonus	21.70	13.22	15	19551	4621	63464835
Wound	21.15	13.22	12	19554	163251	63306205
Atrial fibrillation	20.81	13.22	81	19485	116555	63352901
Blood pressure diastolic abnormal	20.77	13.22	24	19542	14518	63454938
Post cardiac arrest syndrome	20.57	13.22	4	19562	24	63469432
Loss of personal independence in daily activities	20.10	13.22	3	19563	97287	63372169
Malignant hypertension	20.01	13.22	9	19557	1204	63468252
Use of accessory respiratory muscles	19.73	13.22	6	19560	265	63469191
Rheumatoid arthritis	19.53	13.22	30	19536	253789	63215667
Vasculitis	19.49	13.22	26	19540	18183	63451273
Hyperreflexia	18.40	13.22	15	19551	5919	63463537
Myocardial infarction	18.33	13.22	70	19496	99823	63369633
Renal atrophy	18.29	13.22	9	19557	1473	63467983
Hypertensive encephalopathy	18.21	13.22	7	19559	631	63468825
Therapeutic product effect incomplete	17.99	13.22	8	19558	125048	63344408
Pain of skin	17.97	13.22	20	19546	11614	63457842
Oral discharge	17.93	13.22	5	19561	162	63469294
Facial pain	17.78	13.22	19	19547	10542	63458914
Abdominal discomfort	17.76	13.22	46	19520	320839	63148617
Condition aggravated	17.74	13.22	64	19502	402153	63067303
Eye pruritus	17.49	13.22	25	19541	18646	63450810
Anaemia	17.46	13.22	152	19414	293278	63176178
Dehydration	17.45	13.22	102	19464	173252	63296204
Anaphylactoid reaction	17.32	13.22	12	19554	3711	63465745
Duodenal ulcer perforation	17.31	13.22	3	19563	87206	63382250
Sinusitis	17.23	13.22	27	19539	226626	63242830
Swelling	17.21	13.22	37	19529	275341	63194115
Circulatory collapse	17.16	13.22	27	19539	21911	63447545
Angiosclerosis	17.10	13.22	3	19563	9	63469447
Musculoskeletal stiffness	17.09	13.22	19	19547	184599	63284857
Infusion related reaction	17.05	13.22	31	19535	245490	63223966
Hallucination, visual	16.86	13.22	25	19541	19273	63450183
Hypokalaemia	16.84	13.22	70	19496	103734	63365722
Product dose omission issue	16.80	13.22	29	19537	234284	63235172
Gingival bleeding	16.69	13.22	20	19546	12567	63456889
Amnesia	16.59	13.22	46	19520	55539	63413917
Familial periodic paralysis	16.53	13.22	4	19562	73	63469383
Psoriatic arthropathy	16.41	13.22	4	19562	91516	63377940
Subarachnoid haemorrhage	16.22	13.22	21	19545	14262	63455194
Chronic kidney disease	16.03	13.22	40	19526	45358	63424098
Heart rate decreased	15.94	13.22	40	19526	45520	63423936
Dyspnoea	15.93	13.22	289	19277	661024	62808432
Ill-defined disorder	15.82	13.22	3	19563	81752	63387704
Exposure during pregnancy	15.54	13.22	15	19551	155532	63313924
Simple partial seizures	15.33	13.22	6	19560	567	63468889
Product monitoring error	15.25	13.22	12	19554	4504	63464952
Nephrogenic systemic fibrosis	15.15	13.22	12	19554	4544	63464912
Fasting	15.15	13.22	3	19563	20	63469436
Jaundice	15.10	13.22	30	19536	29221	63440235
Duodenal ulcer	14.94	13.22	15	19551	7741	63461715
Electrocardiogram ST-T segment abnormal	14.87	13.22	5	19561	306	63469150
Drug dispensed to wrong patient	14.70	13.22	5	19561	317	63469139
Shock	14.51	13.22	26	19540	23437	63446019
Injection site erythema	14.21	13.22	4	19562	83170	63386286
Infection	14.14	13.22	31	19535	229142	63240314
Aortic stenosis	14.13	13.22	12	19554	5008	63464448
Scrotal oedema	14.07	13.22	3	19563	30	63469426
Blood glucose increased	13.99	13.22	57	19509	83699	63385757
Blood pressure systolic increased	13.92	13.22	39	19527	47358	63422098
Pemphigoid	13.78	13.22	14	19552	7330	63462126
Oral herpes	13.77	13.22	27	19539	26047	63443409
Left ventricular hypertrophy	13.54	13.22	12	19554	5303	63464153
Blood pressure fluctuation	13.50	13.22	38	19528	46279	63423177
Chest pain	13.43	13.22	113	19453	215846	63253610

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Syncope	165.07	11.22	324	36654	91127	34828826
Orthostatic hypotension	107.78	11.22	135	36843	25784	34894169
Mycotic allergy	105.54	11.22	35	36943	573	34919380
Off label use	103.22	11.22	179	36799	419345	34500608
Mite allergy	100.61	11.22	35	36943	667	34919286
Spirometry abnormal	99.56	11.22	35	36943	689	34919264
Dust allergy	95.51	11.22	36	36942	870	34919083
Hypertensive crisis	95.44	11.22	77	36901	8674	34911279
Conjunctivitis allergic	93.38	11.22	38	36940	1132	34918821
Asthma	90.38	11.22	162	36816	42494	34877459
Carotid arteriosclerosis	82.51	11.22	40	36938	1818	34918135
Renal cyst haemorrhage	73.25	11.22	27	36951	612	34919341
Full blood count abnormal	67.85	11.22	91	36887	18577	34901376
Presyncope	64.87	11.22	90	36888	18969	34900984
Rectal prolapse	64.66	11.22	23	36955	469	34919484
Left ventricular hypertrophy	63.26	11.22	59	36919	8071	34911882
Febrile neutropenia	61.67	11.22	34	36944	136815	34783138
Blood pressure inadequately controlled	61.41	11.22	37	36941	2603	34917350
Arteriosclerosis	59.01	11.22	68	36910	11900	34908053
Drug abuse	58.86	11.22	16	36962	99080	34820873
Normochromic normocytic anaemia	58.28	11.22	43	36935	4244	34915709
Productive cough	56.39	11.22	124	36854	37689	34882264
Middle insomnia	56.10	11.22	51	36927	6751	34913202
Renal artery stenosis	56.01	11.22	33	36945	2228	34917725
Oedema peripheral	55.26	11.22	262	36716	119550	34800403
Drug interaction	54.54	11.22	417	36561	225529	34694424
Hypotension	52.89	11.22	408	36570	221241	34698712
Intraductal papillary mucinous neoplasm	51.87	11.22	20	36958	515	34919438
Aortic dilatation	49.97	11.22	26	36952	1375	34918578
Neutropenia	49.21	11.22	56	36922	156722	34763231
SARS-CoV-2 antibody test positive	48.91	11.22	18	36960	406	34919547
Hyperkalaemia	46.30	11.22	170	36808	69219	34850734
Aortic valve incompetence	46.23	11.22	43	36935	5861	34914092
Vena cava injury	45.09	11.22	16	36962	324	34919629
Loss of consciousness	45.03	11.22	190	36788	82477	34837476
Bradycardia	44.76	11.22	178	36800	75240	34844713
Gastrointestinal tract mucosal pigmentation	42.86	11.22	17	36961	473	34919480
Abdominal wall haemorrhage	42.86	11.22	17	36961	473	34919480
Dizziness	41.36	11.22	382	36596	218139	34701814
Complications of transplanted kidney	40.86	11.22	36	36942	4573	34915380
Vascular anastomotic haemorrhage	39.94	11.22	14	36964	273	34919680
Vascular compression	39.85	11.22	15	36963	361	34919592
Hyperparathyroidism secondary	39.14	11.22	23	36955	1545	34918408
Delayed graft function	38.86	11.22	26	36952	2195	34917758
Atrial fibrillation	37.76	11.22	240	36738	122153	34797800
Perineal cyst	36.83	11.22	13	36965	259	34919694
Blood creatinine increased	36.25	11.22	197	36781	94779	34825174
Tricuspid valve incompetence	36.11	11.22	48	36930	9712	34910241
Ventricular hyperkinesia	35.76	11.22	12	36966	204	34919749
Metabolic acidosis	35.22	11.22	114	36864	43566	34876387
Wheezing	35.16	11.22	110	36868	41292	34878661
Drug ineffective	34.23	11.22	314	36664	456437	34463516
Biliary cirrhosis	34.13	11.22	10	36968	106	34919847
Right atrial enlargement	33.45	11.22	12	36966	251	34919702
Hypertensive heart disease	32.39	11.22	24	36954	2384	34917569
Mitral valve thickening	32.14	11.22	13	36965	381	34919572
Renal impairment	32.08	11.22	190	36788	94323	34825630
Nephrectomy	31.92	11.22	16	36962	782	34919171
Mycobacterium test positive	31.28	11.22	13	36965	409	34919544
Arteriosclerosis coronary artery	31.13	11.22	51	36927	12434	34907519
Hypochromasia	31.12	11.22	12	36966	309	34919644
Hyperparathyroidism	30.68	11.22	18	36960	1206	34918747
Orthopnoea	30.36	11.22	32	36946	5071	34914882
Vertigo	29.66	11.22	76	36902	25460	34894493
Foetal exposure during pregnancy	29.53	11.22	3	36975	38098	34881855
Blood 25-hydroxycholecalciferol decreased	29.49	11.22	11	36967	258	34919695
Myocardial infarction	29.42	11.22	224	36754	120861	34799092
Diverticulum intestinal	29.03	11.22	28	36950	3993	34915960
Atrioventricular block first degree	29.00	11.22	34	36944	6058	34913895
Mean cell volume increased	28.59	11.22	25	36953	3144	34916809
Mean platelet volume increased	28.43	11.22	13	36965	517	34919436
Primary hyperaldosteronism	28.28	11.22	8	36970	74	34919879
Left ventricular enlargement	27.86	11.22	14	36964	688	34919265
Floppy iris syndrome	27.73	11.22	11	36967	306	34919647
Haemodialysis	27.61	11.22	44	36934	10482	34909471
Mucosal inflammation	27.58	11.22	4	36974	38618	34881335
Aortic arteriosclerosis	27.45	11.22	29	36949	4607	34915346
Atrioventricular block	27.32	11.22	38	36940	8025	34911928
Spinal osteoarthritis	27.22	11.22	37	36941	7646	34912307
Death	27.10	11.22	280	36698	397769	34522184
Renal cyst	26.64	11.22	40	36938	9053	34910900
Product use issue	26.62	11.22	17	36961	63199	34856754
Lung diffusion test decreased	26.47	11.22	13	36965	608	34919345
Scrotal oedema	26.37	11.22	19	36959	1807	34918146
Large intestine polyp	26.37	11.22	37	36941	7877	34912076
Subacute hepatic failure	26.33	11.22	8	36970	97	34919856
Sleep disorder due to a general medical condition	26.30	11.22	30	36948	5191	34914762
Actinic keratosis	26.04	11.22	28	36950	4539	34915414
Hypertension	25.99	11.22	239	36739	136204	34783749
Completed suicide	25.74	11.22	40	36938	98128	34821825
Septic shock	25.54	11.22	23	36955	71811	34848142
Erosive duodenitis	25.04	11.22	18	36960	1706	34918247
Left atrial enlargement	24.52	11.22	14	36964	891	34919062
Nocturia	24.51	11.22	41	36937	10169	34909784
Myopathy	23.33	11.22	43	36935	11511	34908442
Benign prostatic hyperplasia	23.28	11.22	49	36929	14446	34905507
Electrocardiogram T wave inversion	22.99	11.22	19	36959	2212	34917741
Acute kidney injury	22.93	11.22	451	36527	304537	34615416
Angioedema	22.79	11.22	89	36889	37285	34882668
Spinal stenosis	22.78	11.22	28	36950	5241	34914712
Chronic kidney disease	22.63	11.22	95	36883	41115	34878838
Intervertebral disc space narrowing	22.53	11.22	14	36964	1041	34918912
Blood urea increased	22.47	11.22	77	36901	30287	34889666
Mitral valve incompetence	22.26	11.22	49	36929	14894	34905059
Blood potassium increased	22.25	11.22	52	36926	16443	34903510
Inappropriate schedule of product administration	22.08	11.22	20	36958	62276	34857677
Duplicate therapy error	22.05	11.22	8	36970	173	34919780
Thrombocytopenia	21.90	11.22	88	36890	156159	34763794
Product dose omission issue	21.88	11.22	60	36918	119651	34800302
Swelling of eyelid	21.86	11.22	14	36964	1097	34918856
Nodule	21.42	11.22	31	36947	6788	34913165
Sepsis	21.38	11.22	97	36881	166464	34753489
Haematuria	21.25	11.22	107	36871	49959	34869994
Tooth avulsion	21.24	11.22	5	36973	20	34919933
Tongue haemorrhage	21.19	11.22	11	36967	579	34919374
Hepatosplenomegaly	21.08	11.22	24	36954	4145	34915808
Vitamin D decreased	21.04	11.22	22	36956	3454	34916499
Endoscopy upper gastrointestinal tract abnormal	20.98	11.22	6	36972	58	34919895
Blood pressure ambulatory increased	20.79	11.22	6	36972	60	34919893
Melaena	20.56	11.22	83	36895	35297	34884656
Cardiac autonomic neuropathy	20.53	11.22	6	36972	63	34919890
Bundle branch block left	19.99	11.22	28	36950	5951	34914002
Disease progression	19.87	11.22	54	36924	108023	34811930
Angina pectoris	19.37	11.22	75	36903	31288	34888665
Treatment failure	19.06	11.22	13	36965	46684	34873269
Myalgia	18.97	11.22	153	36825	83957	34835996
Toxic neuropathy	18.87	11.22	10	36968	549	34919404
Renal failure	18.80	11.22	216	36762	130341	34789612
Shock hypoglycaemic	18.22	11.22	6	36972	96	34919857
Urine flow decreased	18.09	11.22	13	36965	1231	34918722
Obstructive airways disorder	17.87	11.22	46	36932	15448	34904505
Pyrexia	17.73	11.22	247	36731	332766	34587187
Phaeochromocytoma	17.61	11.22	7	36971	196	34919757
Multiple organ dysfunction syndrome	17.51	11.22	34	36944	76532	34843421
Thrombosis	17.47	11.22	102	36876	50356	34869597
Toxic optic neuropathy	17.45	11.22	11	36967	839	34919114
CADASIL	17.36	11.22	6	36972	112	34919841
Sprue-like enteropathy	16.82	11.22	9	36969	504	34919449
Glycosylated haemoglobin increased	16.64	11.22	37	36941	11323	34908630
Hypokalaemia	16.61	11.22	112	36866	58102	34861851
Infusion related reaction	16.56	11.22	19	36959	53038	34866915
High density lipoprotein decreased	16.41	11.22	19	36959	3341	34916612
Nausea	16.40	11.22	257	36721	339651	34580302
Human polyomavirus infection	16.21	11.22	10	36968	734	34919219
Circulatory collapse	16.14	11.22	54	36924	20984	34898969
Xanthopsia	15.76	11.22	6	36972	149	34919804
Haemorrhoids	15.52	11.22	42	36936	14533	34905420
Malignant neoplasm progression	15.44	11.22	45	36933	88001	34831952
Genital swelling	15.29	11.22	6	36972	162	34919791
Leukopenia	15.18	11.22	27	36951	62829	34857124
Diastolic dysfunction	14.94	11.22	25	36953	6202	34913751
Spermatozoa progressive motility abnormal	14.77	11.22	4	36974	31	34919922
Dilatation ventricular	14.75	11.22	16	36962	2620	34917333
Activated partial thromboplastin time prolonged	14.67	11.22	30	36948	8665	34911288
Optic nerve disorder	14.56	11.22	9	36969	663	34919290
Crystalluria	14.55	11.22	8	36970	473	34919480
Gravitational oedema	14.46	11.22	9	36969	671	34919282
Drug monitoring procedure not performed	14.40	11.22	7	36971	320	34919633
Dermatosis	14.38	11.22	7	36971	321	34919632
End stage renal disease	14.28	11.22	30	36948	8831	34911122
Psychotic symptom	14.24	11.22	13	36965	1730	34918223
Microalbuminuria	14.20	11.22	9	36969	693	34919260
Blood pressure increased	14.16	11.22	149	36829	87953	34832000
Product use in unapproved indication	14.14	11.22	70	36908	117429	34802524
Clang associations	14.14	11.22	4	36974	37	34919916
Face oedema	14.13	11.22	35	36943	11481	34908472
Hypochromic anaemia	14.09	11.22	10	36968	929	34919024
Haemoglobin decreased	14.03	11.22	192	36786	120580	34799373
Aplasia pure red cell	13.89	11.22	24	36954	6108	34913845
Electrocardiogram ST segment elevation	13.88	11.22	22	36956	5216	34914737
Supine hypertension	13.78	11.22	7	36971	352	34919601
Pneumonia	13.76	11.22	286	36692	362341	34557612
Agitation	13.55	11.22	25	36953	57374	34862579
Toxicity to various agents	13.55	11.22	141	36837	200221	34719732
Visual field defect	13.53	11.22	20	36958	4463	34915490
Infection	13.50	11.22	50	36928	90865	34829088
Respiratory failure	13.46	11.22	64	36914	108508	34811445
Glomerular filtration rate decreased	13.45	11.22	37	36941	12924	34907029
Anuria	13.21	11.22	32	36946	10353	34909600
Adrenocortical insufficiency acute	13.20	11.22	12	36966	1588	34918365
Sinus node dysfunction	12.89	11.22	19	36959	4230	34915723
Spermatozoa progressive motility decreased	12.89	11.22	5	36973	131	34919822
Rhabdomyolysis	12.76	11.22	119	36859	68044	34851909
Chronic obstructive pulmonary disease	12.71	11.22	92	36886	48826	34871127
Obstruction	12.65	11.22	15	36963	2704	34917249
Hypoglycaemia	12.64	11.22	100	36878	54540	34865413
Prostatic haemorrhage	12.62	11.22	6	36972	261	34919692
Venous thrombosis limb	12.62	11.22	13	36965	2006	34917947
Drug dependence	12.45	11.22	5	36973	24212	34895741
Cerebral haemorrhage	12.33	11.22	71	36907	34866	34885087
Cardiac failure	12.25	11.22	149	36829	91099	34828854
Hepatic steatosis	12.24	11.22	45	36933	18317	34901636
Post transplant distal limb syndrome	12.05	11.22	6	36972	289	34919664
Optic atrophy	12.05	11.22	9	36969	905	34919048
Drug ineffective for unapproved indication	12.03	11.22	5	36973	23710	34896243
Adrenal cyst	12.01	11.22	5	36973	158	34919795
Blood chloride increased	11.96	11.22	15	36963	2866	34917087
Ischaemic cardiomyopathy	11.93	11.22	23	36955	6366	34913587
Inappropriate affect	11.75	11.22	8	36970	695	34919258
Intentional product use issue	11.67	11.22	29	36949	59787	34860166
Hypotensive crisis	11.66	11.22	4	36974	73	34919880
Blood disorder	11.65	11.22	16	36962	3338	34916615
Haemoglobinaemia	11.61	11.22	5	36973	172	34919781
Jaundice hepatocellular	11.51	11.22	4	36974	76	34919877
Asthenia	11.47	11.22	340	36638	244911	34675042
Gastrooesophageal reflux disease	11.44	11.22	74	36904	37850	34882103
Cardio-respiratory arrest	11.41	11.22	26	36952	55247	34864706

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Syncope	288.11	11.20	449	49247	179000	79515692
Hypertensive crisis	208.84	11.20	141	49555	20629	79674063
Hyperkalaemia	190.08	11.20	291	49405	114107	79580585
Hypotension	165.95	11.20	626	49070	439691	79255001
Drug interaction	158.69	11.20	593	49103	414590	79280102
Orthostatic hypotension	153.27	11.20	182	49514	55982	79638710
Rectal prolapse	113.93	11.20	45	49651	2133	79692559
Acute kidney injury	108.20	11.20	621	49075	518783	79175909
Off label use	104.35	11.20	260	49436	906955	78787737
Spirometry abnormal	104.01	11.20	34	49662	925	79693767
Bradycardia	103.83	11.20	248	49448	135309	79559383
Mite allergy	95.71	11.20	34	49662	1196	79693496
Carotid arteriosclerosis	95.49	11.20	42	49654	2614	79692078
Conjunctivitis allergic	95.12	11.20	37	49659	1683	79693009
Renal artery stenosis	93.63	11.20	45	49651	3437	79691255
Renal impairment	93.37	11.20	262	49434	157521	79537171
Presyncope	92.69	11.20	121	49575	40933	79653759
Dust allergy	91.94	11.20	35	49661	1501	79693191
Mycotic allergy	88.72	11.20	34	49662	1485	79693207
Renal cyst haemorrhage	85.14	11.20	27	49669	665	79694027
Hyponatraemia	85.10	11.20	274	49422	177574	79517118
Arteriosclerosis	79.86	11.20	76	49620	18151	79676541
Left ventricular hypertrophy	76.13	11.20	60	49636	11131	79683561
Angioedema	72.66	11.20	152	49544	75883	79618809
Atrial fibrillation	69.91	11.20	276	49420	197610	79497082
Oedema peripheral	69.24	11.20	326	49370	251962	79442730
Contraindicated product administered	67.75	11.20	9	49687	157529	79537163
Metabolic acidosis	67.53	11.20	155	49541	82374	79612318
Blood pressure inadequately controlled	67.06	11.20	44	49652	6133	79688559
Loss of consciousness	66.54	11.20	243	49453	167700	79526992
Product use issue	64.51	11.20	25	49671	209797	79484895
Drug intolerance	64.03	11.20	43	49653	264076	79430616
Blood creatinine increased	62.82	11.20	226	49470	154831	79539861
Pain	61.23	11.20	229	49467	703573	78991119
Treatment failure	60.04	11.20	16	49680	170470	79524222
Renal failure	59.81	11.20	266	49430	200702	79493990
Drug ineffective	59.26	11.20	413	49283	1080500	78614192
SARS-CoV-2 antibody test positive	57.63	11.20	18	49678	421	79694271
Alopecia	56.97	11.20	37	49659	231318	79463374
Dizziness	56.63	11.20	538	49158	525903	79168789
Therapeutic product effect decreased	56.54	11.20	16	49680	163847	79530845
Full blood count abnormal	56.25	11.20	95	49601	40379	79654313
Normochromic normocytic anaemia	55.97	11.20	43	49653	7684	79687008
Intraductal papillary mucinous neoplasm	54.39	11.20	20	49676	778	79693914
Febrile neutropenia	54.14	11.20	39	49657	230960	79463732
Middle insomnia	53.91	11.20	58	49638	16011	79678681
Vena cava injury	52.86	11.20	16	49680	336	79694356
Hepatic enzyme increased	52.53	11.20	24	49672	182586	79512106
Bladder prolapse	52.40	11.20	23	49673	1424	79693268
Aortic valve incompetence	52.09	11.20	45	49651	9485	79685207
Arthropathy	51.38	11.20	23	49673	177088	79517604
Blood urea increased	50.71	11.20	101	49595	48689	79646003
Aortic dilatation	50.49	11.20	24	49672	1788	79692904
Hypoglycaemia	49.90	11.20	158	49538	101436	79593256
Abdominal wall haemorrhage	49.55	11.20	18	49678	676	79694016
Vitamin D decreased	49.30	11.20	44	49652	9681	79685011
Productive cough	47.69	11.20	142	49554	88189	79606503
Scrotal oedema	47.27	11.20	22	49674	1563	79693129
Vascular anastomotic haemorrhage	47.22	11.20	14	49682	273	79694419
Benign prostatic hyperplasia	46.33	11.20	46	49650	11566	79683126
Systemic lupus erythematosus	45.33	11.20	10	49686	121139	79573553
Blood potassium increased	45.12	11.20	72	49624	29203	79665489
Pemphigus	44.50	11.20	5	49691	99577	79595115
Perineal cyst	43.73	11.20	13	49683	256	79694436
Neutropenia	43.58	11.20	70	49626	287640	79407052
Complications of transplanted kidney	43.02	11.20	34	49662	6332	79688360
Rheumatoid arthritis	42.88	11.20	40	49656	208430	79486262
Maternal exposure during pregnancy	42.40	11.20	16	49680	136522	79558170
Cardiac failure	42.37	11.20	200	49496	154642	79540050
Vascular compression	41.40	11.20	15	49681	559	79694133
Melaena	40.88	11.20	106	49590	60784	79633908
Infusion related reaction	40.86	11.20	50	49646	230187	79464505
Glomerular filtration rate decreased	40.86	11.20	60	49636	22642	79672050
Delayed graft function	40.57	11.20	26	49670	3481	79691211
Sinusitis	39.63	11.20	38	49658	195463	79499229
Arteriosclerosis coronary artery	39.41	11.20	52	49644	17764	79676928
Gastrointestinal tract mucosal pigmentation	39.03	11.20	17	49679	1033	79693659
Ventricular hyperkinesia	38.17	11.20	12	49684	287	79694405
Mitral valve thickening	37.82	11.20	13	49683	414	79694278
Chronic kidney disease	37.28	11.20	108	49588	66046	79628646
Mycobacterium test positive	37.18	11.20	13	49683	436	79694256
Discomfort	36.92	11.20	16	49680	125601	79569091
Hyperparathyroidism secondary	36.55	11.20	22	49674	2638	79692054
Product dose omission issue	35.83	11.20	62	49634	247475	79447217
Glossodynia	35.80	11.20	10	49686	103327	79591365
Tricuspid valve incompetence	35.33	11.20	52	49644	19660	79675032
Right atrial enlargement	34.89	11.20	12	49684	383	79694309
Biliary cirrhosis	34.85	11.20	10	49686	173	79694519
Circulatory collapse	34.46	11.20	74	49622	37594	79657098
Left ventricular enlargement	34.14	11.20	14	49682	732	79693960
Hypertensive heart disease	34.01	11.20	25	49671	4181	79690511
Mitral valve incompetence	33.19	11.20	62	49634	28503	79666189
Erosive duodenitis	33.00	11.20	19	49677	2098	79692594
Large intestine polyp	32.71	11.20	40	49656	12668	79682024
Renal cyst	32.59	11.20	43	49653	14689	79680003
Completed suicide	32.53	11.20	65	49631	245702	79448990
Blood pressure increased	32.29	11.20	234	49462	211126	79483566
Primary hyperaldosteronism	31.85	11.20	9	49687	147	79694545
Orthopnoea	31.43	11.20	35	49661	10038	79684654
Blood 25-hydroxycholecalciferol decreased	31.21	11.20	11	49685	378	79694314
Sinus bradycardia	30.85	11.20	56	49640	25191	79669501
Myocardial infarction	30.55	11.20	208	49488	183921	79510771
Hypokalaemia	29.69	11.20	172	49524	143868	79550824
Atrioventricular block	29.55	11.20	40	49656	14001	79680691
Infection	29.42	11.20	67	49629	241645	79453047
Haematuria	29.28	11.20	102	49594	68734	79625958
Sopor	29.23	11.20	64	49632	32946	79661746
Angina pectoris	28.71	11.20	84	49612	51648	79643044
Hypochromasia	28.28	11.20	12	49684	684	79694008
Nasopharyngitis	28.06	11.20	74	49622	253807	79440885
Rhabdomyolysis	28.04	11.20	133	49563	102998	79591694
Cardiac failure congestive	28.03	11.20	168	49528	142234	79552458
Actinic keratosis	28.01	11.20	26	49670	6016	79688676
Duodenal ulcer perforation	27.94	11.20	4	49692	66207	79628485
Nephrectomy	27.79	11.20	17	49679	2098	79692594
Gallbladder polyp	27.24	11.20	13	49683	977	79693715
Exposure during pregnancy	26.52	11.20	15	49681	101117	79593575
Swollen tongue	26.44	11.20	72	49624	42498	79652194
Aortic arteriosclerosis	26.14	11.20	30	49666	8888	79685804
End stage renal disease	26.00	11.20	35	49661	12185	79682507
Stomatitis	25.89	11.20	32	49664	146725	79547967
Nocturia	25.84	11.20	37	49659	13644	79681048
Mean platelet volume increased	25.72	11.20	13	49683	1107	79693585
CADASIL	25.71	11.20	6	49690	43	79694649
Haemodialysis	25.71	11.20	43	49653	18125	79676567
Hyperuricaemia	25.42	11.20	34	49662	11765	79682927
Mean cell volume increased	25.37	11.20	25	49671	6228	79688464
Diverticulum intestinal	25.32	11.20	29	49667	8576	79686116
Pericarditis	25.19	11.20	17	49679	104219	79590473
Left atrial enlargement	24.84	11.20	13	49683	1190	79693502
Floppy iris syndrome	24.38	11.20	9	49687	354	79694338
Hypertension	24.33	11.20	314	49382	330678	79364014
Injection site inflammation	24.25	11.20	20	49676	3956	79690736
Folliculitis	24.19	11.20	3	49693	55377	79639315
Hepatosplenomegaly	24.13	11.20	24	49672	6045	79688647
Subacute hepatic failure	24.09	11.20	8	49688	229	79694463
Tongue haemorrhage	24.02	11.20	12	49684	997	79693695
Atrioventricular block first degree	23.92	11.20	34	49662	12457	79682235
Lung diffusion test decreased	23.80	11.20	13	49683	1297	79693395
Helicobacter infection	23.67	11.20	7	49689	69697	79624995
Blood pressure ambulatory increased	23.59	11.20	6	49690	64	79694628
Cardiac autonomic neuropathy	23.59	11.20	6	49690	64	79694628
Ill-defined disorder	23.53	11.20	6	49690	65869	79628823
Hyperparathyroidism	23.48	11.20	18	49678	3206	79691486
Endoscopy upper gastrointestinal tract abnormal	23.42	11.20	6	49690	66	79694626
Product use in unapproved indication	23.32	11.20	79	49617	250280	79444412
Intervertebral disc space narrowing	22.94	11.20	14	49682	1721	79692971
Acute myocardial infarction	22.91	11.20	102	49594	76934	79617758
Urine flow decreased	22.82	11.20	12	49684	1109	79693583
Ischaemic cardiomyopathy	22.75	11.20	26	49670	7669	79687023
Fibromyalgia	22.71	11.20	6	49690	64334	79630358
Thermal burn	22.55	11.20	25	49671	7135	79687557
Haemoglobin decreased	22.32	11.20	224	49472	221895	79472797
Duplicate therapy error	22.06	11.20	8	49688	299	79694393
Penile oedema	21.76	11.20	8	49688	311	79694381
Musculoskeletal stiffness	21.71	11.20	48	49648	174960	79519732
Cerebral haemorrhage	21.60	11.20	82	49614	57591	79637101
Spinal osteoarthritis	21.26	11.20	38	49658	16889	79677803
Coronary artery disease	21.24	11.20	89	49607	65385	79629307
Gastrointestinal disorder	21.18	11.20	27	49669	122178	79572514
Rectal haemorrhage	21.18	11.20	99	49597	76201	79618491
Sinus node dysfunction	21.06	11.20	25	49671	7676	79687016
Swelling of eyelid	20.83	11.20	18	49678	3793	79690899
Dyspnoea	20.81	11.20	689	49007	856336	78838356
Wrong patient	20.65	11.20	8	49688	360	79694332
Mucosal membrane hyperplasia	20.52	11.20	5	49691	44	79694648
Muscle injury	20.34	11.20	3	49693	48558	79646134
Glycosylated haemoglobin increased	20.16	11.20	40	49656	19220	79675472
Angiosclerosis	19.99	11.20	4	49692	12	79694680
Renin increased	19.96	11.20	7	49689	237	79694455
Dermatosis	19.95	11.20	9	49687	595	79694097
Injection site erythema	19.93	11.20	12	49684	78185	79616507
Nausea	19.90	11.20	450	49246	956746	78737946
Erectile dysfunction	19.82	11.20	34	49662	14630	79680062
Kidney transplant rejection	19.78	11.20	28	49668	10218	79684474
Fasting	19.60	11.20	5	49691	54	79694638
Abdominal discomfort	19.55	11.20	85	49611	250642	79444050
Joint swelling	19.51	11.20	103	49593	288543	79406149
Myopathy	19.51	11.20	41	49655	20522	79674170
Vertigo	19.44	11.20	90	49606	68992	79625700
Anaemia	19.41	11.20	387	49309	444628	79250064
Obstructive airways disorder	19.33	11.20	53	49643	31406	79663286
Arthralgia	19.31	11.20	246	49450	571557	79123135
Transient ischaemic attack	18.98	11.20	74	49622	52621	79642071
Wound	18.79	11.20	27	49669	116152	79578540
Asthenia	18.79	11.20	434	49262	511255	79183437
Bundle branch block left	18.69	11.20	29	49667	11484	79683208
Toxic neuropathy	18.57	11.20	10	49686	970	79693722
Diabetic nephropathy	18.34	11.20	15	49681	2932	79691760
Vertebrobasilar insufficiency	18.30	11.20	7	49689	304	79694388
Drug monitoring procedure not performed	18.28	11.20	10	49686	1001	79693691
Prostatic haemorrhage	18.12	11.20	6	49690	170	79694522
Blood pressure decreased	18.09	11.20	115	49581	99351	79595341
Blood uric acid increased	18.08	11.20	31	49665	13329	79681363
Flushing	18.06	11.20	17	49679	88251	79606441
Disease progression	17.97	11.20	57	49639	184305	79510387
High density lipoprotein decreased	17.76	11.20	18	49678	4637	79690055
Post cardiac arrest syndrome	17.76	11.20	4	49692	24	79694668
Wheezing	17.71	11.20	129	49567	116535	79578157
Rash	17.65	11.20	254	49442	578104	79116588
Tubulointerstitial nephritis	17.44	11.20	58	49638	38177	79656515
Blood glucose increased	17.37	11.20	127	49569	114848	79579844
Knee arthroplasty	17.37	11.20	3	49693	43245	79651447
Electrocardiogram T wave inversion	17.34	11.20	19	49677	5353	79689339
Inappropriate schedule of product administration	17.11	11.20	36	49660	133592	79561100
Toxic optic neuropathy	17.05	11.20	10	49686	1143	79693549
Chronic obstructive pulmonary disease	16.94	11.20	101	49595	85318	79609374
Spermatozoa progressive motility abnormal	16.87	11.20	4	49692	31	79694661
Cardiospasm	16.86	11.20	15	49681	3286	79691406
Injection site pruritus	16.84	11.20	3	49693	42280	79652412
Drug abuse	16.79	11.20	49	49647	162642	79532050
Activated partial thromboplastin time prolonged	16.67	11.20	31	49665	14197	79680495
Nephrogenic anaemia	16.58	11.20	16	49680	3886	79690806
Priapism	16.43	11.20	17	49679	4488	79690204
Proteinuria	16.36	11.20	51	49645	32451	79662241
Intentional product use issue	16.29	11.20	45	49651	152067	79542625
Electrocardiogram ST segment elevation	16.29	11.20	23	49673	8374	79686318
Clang associations	16.24	11.20	4	49692	37	79694655
Blood chloride increased	16.23	11.20	18	49678	5138	79689554
Supine hypertension	16.20	11.20	7	49689	417	79694275
Myalgia	16.20	11.20	182	49514	185459	79509233
Phaeochromocytoma	16.08	11.20	8	49688	659	79694033
Decreased ventricular preload	16.05	11.20	4	49692	39	79694653
Shock hypoglycaemic	15.90	11.20	6	49690	251	79694441
Accelerated hypertension	15.69	11.20	8	49688	694	79693998
Herpes zoster	15.69	11.20	21	49675	93062	79601630
Simple partial seizures	15.67	11.20	8	49688	696	79693996
Anuria	15.64	11.20	38	49658	20925	79673767
Weight increased	15.56	11.20	105	49591	277281	79417411
Psychotic symptom	15.28	11.20	13	49683	2684	79692008
Irritable bowel syndrome	15.24	11.20	10	49686	62231	79632461
Nephrogenic systemic fibrosis	15.23	11.20	19	49677	6141	79688551
Urinary incontinence	15.18	11.20	58	49638	40851	79653841
Lip swelling	15.18	11.20	58	49638	40853	79653839
Gravitational oedema	15.02	11.20	11	49685	1828	79692864
Human polyomavirus infection	14.81	11.20	9	49687	1097	79693595
Impaired healing	14.54	11.20	20	49676	87635	79607057
Injection site reaction	14.54	11.20	8	49688	54777	79639915
Muscle twitching	14.50	11.20	41	49655	24723	79669969
Genital swelling	14.45	11.20	6	49690	324	79694368
Spermatozoa progressive motility decreased	14.41	11.20	4	49692	61	79694631
Adrenal cyst	14.35	11.20	5	49691	166	79694526
Drug ineffective for unapproved indication	14.31	11.20	7	49689	51231	79643461
Muscular dystrophy	14.26	11.20	5	49691	169	79694523
Sleep disorder due to a general medical condition	14.17	11.20	29	49667	14248	79680444
Septic shock	14.17	11.20	35	49661	122766	79571926
Hyperlipidaemia	14.12	11.20	42	49654	26051	79668641
Haemorrhoids	14.01	11.20	45	49651	29083	79665609
Shock	13.97	11.20	59	49637	43489	79651203
Condition aggravated	13.94	11.20	224	49472	500900	79193792
Fatigue	13.86	11.20	458	49238	929269	78765423
Bronchiolitis	13.84	11.20	15	49681	4173	79690519
Lactic acidosis	13.83	11.20	83	49613	70276	79624416
Clonus	13.66	11.20	19	49677	6821	79687871
Death	13.60	11.20	260	49436	566254	79128438
Palmoplantar keratoderma	13.51	11.20	14	49682	3702	79690990
Bradyphrenia	13.51	11.20	24	49672	10616	79684076
Feeling cold	13.48	11.20	44	49652	28685	79666007
Ventricular hypertrophy	13.45	11.20	19	49677	6919	79687773
Crystalluria	13.41	11.20	8	49688	943	79693749
Hypersensitivity	13.38	11.20	102	49594	262137	79432555
Sprue-like enteropathy	13.37	11.20	9	49687	1309	79693383
Squamous cell carcinoma of skin	13.33	11.20	28	49668	14005	79680687
Electrocardiogram T wave peaked	13.23	11.20	8	49688	967	79693725
Aplasia pure red cell	13.13	11.20	20	49676	7790	79686902
Tooth avulsion	13.13	11.20	4	49692	86	79694606
Urticaria	13.12	11.20	65	49631	185136	79509556
Aortic valve sclerosis	13.10	11.20	10	49686	1770	79692922
Pruritus genital	13.00	11.20	15	49681	4471	79690221
Cerebrovascular accident	12.98	11.20	151	49545	155141	79539551
Cardiomegaly	12.94	11.20	41	49655	26311	79668381
Thrombosis	12.76	11.20	93	49603	84007	79610685
Eosinophilia	12.70	11.20	59	49637	45286	79649406
Obstruction	12.67	11.20	15	49681	4595	79690097
Oliguria	12.64	11.20	30	49666	16279	79678413
Duodenal ulcer	12.57	11.20	30	49666	16339	79678353
Psoriasis	12.44	11.20	23	49673	89564	79605128
Angina unstable	12.38	11.20	30	49666	16497	79678195
Aortic stenosis	12.33	11.20	19	49677	7476	79687216
Sepsis	12.28	11.20	108	49588	269320	79425372
Blood disorder	12.27	11.20	20	49676	8253	79686439
Anaphylactoid reaction	12.26	11.20	16	49680	5406	79689286
Visual field defect	12.26	11.20	21	49675	9024	79685668
Neuropathy peripheral	12.21	11.20	46	49650	141259	79553433
Toxicity to various agents	12.20	11.20	187	49509	421353	79273339
Spinal stenosis	12.19	11.20	29	49667	15762	79678930
Oral discharge	12.16	11.20	5	49691	263	79694429
Swelling face	12.13	11.20	81	49615	71131	79623561
Illness	12.04	11.20	7	49689	46504	79648188
Adrenocortical insufficiency acute	12.04	11.20	12	49684	3031	79691661
Hypotensive crisis	11.99	11.20	4	49692	116	79694576
Coronary artery stenosis	11.97	11.20	25	49671	12459	79682233
Bundle branch block	11.80	11.20	9	49687	1591	79693101
Mucosal inflammation	11.80	11.20	18	49678	75562	79619130
Use of accessory respiratory muscles	11.76	11.20	6	49690	521	79694171
Haemoglobinaemia	11.72	11.20	5	49691	289	79694403
Blood lactic acid abnormal	11.71	11.20	3	49693	33	79694659
Malignant hypertension	11.69	11.20	9	49687	1613	79693079
Ejaculation disorder	11.63	11.20	6	49690	533	79694159
Paraganglion neoplasm	11.55	11.20	3	49693	35	79694657
Venous thrombosis limb	11.42	11.20	14	49682	4443	79690249
Sleep terror	11.42	11.20	14	49682	4444	79690248
Optic nerve disorder	11.26	11.20	8	49688	1269	79693423
Jaundice hepatocellular	11.23	11.20	4	49692	142	79694550

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C02CA04	CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING Alpha-adrenoreceptor antagonists
ATC	G04CA55	GENITO URINARY SYSTEM AND SEX HORMONES UROLOGICALS DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY Alpha-adrenoreceptor antagonists
FDA MoA	N0000000099	Adrenergic alpha-Antagonists
FDA EPC	N0000175553	alpha-Adrenergic Blocker
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:37890	alpha-adrenergic receptor blockaders
CHEBI has role	CHEBI:59844	antihyperplasia drugs
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D058668	Adrenergic alpha-1 Receptor Antagonists
MeSH PA	D000317	Adrenergic alpha-Antagonists
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Benign prostatic hyperplasia	indication	266569009
Priapism	contraindication	6273006	DOID:9286
Stenosis of intestine	contraindication	23065003
Orthostatic hypotension	contraindication	28651003
Low blood pressure	contraindication	45007003
Hepatic failure	contraindication	59927004
Chronic idiopathic constipation	contraindication	82934008
Cataract surgery	contraindication	110473004
Disease of liver	contraindication	235856003	DOID:409
Pyloric obstruction	contraindication	244815007
Syncope	contraindication	271594007
Intraoperative floppy iris syndrome	contraindication	418801006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.22	Basic
pKa2	0.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN	ANTAGONIST	Ki	8.85	WOMBAT-PK	CHEMBL
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN	ANTAGONIST	Ki	9.10	WOMBAT-PK	CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN	ANTAGONIST	Ki	8.80	WOMBAT-PK	CHEMBL
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	6.23	WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	5	WOMBAT-PK
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.85	DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.63	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.55	DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.55	CHEMBL
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	6.83	DRUG MATRIX
Interstitial collagenase	Enzyme	P03956	MMP1_HUMAN		IC50	5.24	DRUG MATRIX
HLA class I histocompatibility antigen, A-3 alpha chain	Unclassified	P04439	1A03_HUMAN		Kd	4.80	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.72	DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.14	CHEMBL
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	9.38	DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	8.81	CHEMBL
5-hydroxytryptamine receptor 4	GPCR		5HT4R_CAVPO		Ki	6.90	DRUG MATRIX

External reference:

ID	Source
4019735	VUID
N0000147827	NUI
D00608	KEGG_DRUG
77883-43-3	SECONDARY_CAS_RN
4019565	VANDF
4019735	VANDF
C0114873	UMLSCUI
CHEBI:4708	CHEBI
CHEMBL707	ChEMBL_ID
CHEMBL1200561	ChEMBL_ID
D017292	MESH_DESCRIPTOR_UI
DB00590	DRUGBANK_ID
7170	IUPHAR_LIGAND_ID
5143	INN_ID
NW1291F1W8	UNII
3157	PUBCHEM_CID
39173	RXNORM
37806	MMSL
40546	MMSL
4637	MMSL
d00726	MMSL
003561	NDDF
004493	NDDF
108556006	SNOMEDCT_US
108557002	SNOMEDCT_US
372508002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2040	TABLET, MULTILAYER, EXTENDED RELEASE	4 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2040	TABLET, MULTILAYER, EXTENDED RELEASE	4 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2040	TABLET, MULTILAYER, EXTENDED RELEASE	4 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2080	TABLET, MULTILAYER, EXTENDED RELEASE	8 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2080	TABLET, MULTILAYER, EXTENDED RELEASE	8 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2080	TABLET, MULTILAYER, EXTENDED RELEASE	8 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2410	TABLET	1 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2410	TABLET	1 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2512	TABLET	2 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2512	TABLET	2 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2614	TABLET	4 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2614	TABLET	4 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2710	TABLET, MULTILAYER, EXTENDED RELEASE	4 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2710	TABLET, MULTILAYER, EXTENDED RELEASE	4 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2710	TABLET, MULTILAYER, EXTENDED RELEASE	4 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2716	TABLET	8 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2716	TABLET	8 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2720	TABLET, MULTILAYER, EXTENDED RELEASE	8 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2720	TABLET, MULTILAYER, EXTENDED RELEASE	8 mg	ORAL	NDA	28 sections
Cardura XL	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2720	TABLET, MULTILAYER, EXTENDED RELEASE	8 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2750	TABLET	1 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2750	TABLET	1 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2760	TABLET	2 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2760	TABLET	2 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2770	TABLET	4 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2770	TABLET	4 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2780	TABLET	8 mg	ORAL	NDA	28 sections
Cardura	HUMAN PRESCRIPTION DRUG LABEL	1	0049-2780	TABLET	8 mg	ORAL	NDA	28 sections
Doxazosin	HUMAN PRESCRIPTION DRUG LABEL	1	0093-2067	TABLET	8 mg	ORAL	ANDA	26 sections
Doxazosin	HUMAN PRESCRIPTION DRUG LABEL	1	0093-2068	TABLET	4 mg	ORAL	ANDA	26 sections