Stem definition | Drug id | CAS RN |
---|---|---|
antihypertensive substances, prazosin derivatives | 954 | 74191-85-8 |
Dose | Unit | Route |
---|---|---|
4 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.59 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 2, 1990 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hyperkalaemia | 153.16 | 13.61 | 125 | 15986 | 47964 | 50541049 |
Hypotension | 123.40 | 13.61 | 247 | 15864 | 235222 | 50353791 |
Hypertensive crisis | 114.81 | 13.61 | 64 | 16047 | 13090 | 50575923 |
Syncope | 105.23 | 13.61 | 146 | 15965 | 102856 | 50486157 |
Drug interaction | 94.58 | 13.61 | 201 | 15910 | 199420 | 50389593 |
Hyponatraemia | 84.61 | 13.61 | 127 | 15984 | 96012 | 50493001 |
Acute kidney injury | 81.99 | 13.61 | 206 | 15905 | 227852 | 50361161 |
Orthostatic hypotension | 55.28 | 13.61 | 57 | 16054 | 29424 | 50559589 |
Bladder prolapse | 54.98 | 13.61 | 21 | 16090 | 1800 | 50587213 |
Renal impairment | 54.18 | 13.61 | 91 | 16020 | 75570 | 50513443 |
Rectal prolapse | 52.19 | 13.61 | 20 | 16091 | 1729 | 50587284 |
Blood pressure increased | 46.42 | 13.61 | 119 | 15992 | 133013 | 50456000 |
Hypoglycaemia | 45.98 | 13.61 | 70 | 16041 | 53511 | 50535502 |
Bradycardia | 45.47 | 13.61 | 77 | 16034 | 64349 | 50524664 |
Gallbladder polyp | 43.79 | 13.61 | 14 | 16097 | 707 | 50588306 |
Drug intolerance | 42.44 | 13.61 | 9 | 16102 | 219095 | 50369918 |
Dizziness | 37.83 | 13.61 | 213 | 15898 | 346156 | 50242857 |
Injection site inflammation | 37.59 | 13.61 | 19 | 16092 | 3186 | 50585827 |
Tubulointerstitial nephritis | 37.13 | 13.61 | 34 | 16077 | 15177 | 50573836 |
Angioedema | 36.32 | 13.61 | 52 | 16059 | 37624 | 50551389 |
Sinus bradycardia | 35.21 | 13.61 | 31 | 16080 | 13152 | 50575861 |
Urinary incontinence | 34.94 | 13.61 | 44 | 16067 | 28164 | 50560849 |
Sopor | 34.69 | 13.61 | 37 | 16074 | 19842 | 50569171 |
Treatment failure | 32.83 | 13.61 | 3 | 16108 | 137634 | 50451379 |
Thermal burn | 32.82 | 13.61 | 20 | 16091 | 4821 | 50584192 |
Renal artery stenosis | 32.31 | 13.61 | 14 | 16097 | 1658 | 50587355 |
Arthropathy | 31.58 | 13.61 | 6 | 16105 | 157900 | 50431113 |
Presyncope | 30.38 | 13.61 | 38 | 16073 | 24160 | 50564853 |
Maternal exposure during pregnancy | 30.05 | 13.61 | 7 | 16104 | 159771 | 50429242 |
Therapeutic product effect decreased | 29.83 | 13.61 | 4 | 16107 | 136046 | 50452967 |
Blood pressure inadequately controlled | 29.45 | 13.61 | 18 | 16093 | 4362 | 50584651 |
Vitamin D decreased | 29.16 | 13.61 | 23 | 16088 | 8383 | 50580630 |
Alopecia | 28.26 | 13.61 | 22 | 16089 | 245025 | 50343988 |
Oedema peripheral | 28.09 | 13.61 | 112 | 15999 | 157849 | 50431164 |
Blood pressure diastolic decreased | 27.13 | 13.61 | 30 | 16081 | 16751 | 50572262 |
Confusional state | 27.02 | 13.61 | 124 | 15987 | 185804 | 50403209 |
Drug ineffective | 26.59 | 13.61 | 153 | 15958 | 819180 | 49769833 |
Abdominal discomfort | 25.22 | 13.61 | 22 | 16089 | 231619 | 50357394 |
Systemic lupus erythematosus | 24.82 | 13.61 | 7 | 16104 | 140615 | 50448398 |
Cardiac failure | 24.46 | 13.61 | 66 | 16045 | 75974 | 50513039 |
Blood pressure systolic abnormal | 24.43 | 13.61 | 20 | 16091 | 7686 | 50581327 |
Blood creatinine increased | 24.39 | 13.61 | 66 | 16045 | 76094 | 50512919 |
Renal failure | 24.33 | 13.61 | 82 | 16029 | 106551 | 50482462 |
Eye infarction | 24.29 | 13.61 | 5 | 16106 | 40 | 50588973 |
Mucosal membrane hyperplasia | 23.97 | 13.61 | 5 | 16106 | 43 | 50588970 |
Glossodynia | 23.95 | 13.61 | 4 | 16107 | 115565 | 50473448 |
Product use issue | 23.65 | 13.61 | 9 | 16102 | 149466 | 50439547 |
Blood pressure diastolic abnormal | 22.99 | 13.61 | 21 | 16090 | 9340 | 50579673 |
Loss of consciousness | 22.72 | 13.61 | 79 | 16032 | 104274 | 50484739 |
Renin increased | 22.70 | 13.61 | 6 | 16105 | 153 | 50588860 |
Clonus | 22.69 | 13.61 | 15 | 16096 | 4160 | 50584853 |
Glomerular filtration rate decreased | 22.69 | 13.61 | 23 | 16088 | 11629 | 50577384 |
Daydreaming | 22.65 | 13.61 | 7 | 16104 | 316 | 50588697 |
Lactic acidosis | 22.38 | 13.61 | 39 | 16072 | 33316 | 50555697 |
Off label use | 22.33 | 13.61 | 77 | 16034 | 474349 | 50114664 |
Atrial fibrillation | 22.13 | 13.61 | 77 | 16034 | 101668 | 50487345 |
Feeling cold | 21.89 | 13.61 | 29 | 16082 | 19502 | 50569511 |
Blood urea increased | 20.48 | 13.61 | 31 | 16080 | 23554 | 50565459 |
Anaemia | 20.47 | 13.61 | 144 | 15967 | 252312 | 50336701 |
Post cardiac arrest syndrome | 20.44 | 13.61 | 4 | 16107 | 24 | 50588989 |
Pain | 20.43 | 13.61 | 105 | 16006 | 578798 | 50010215 |
Cardiac failure congestive | 20.24 | 13.61 | 66 | 16045 | 84316 | 50504697 |
Sinusitis | 20.05 | 13.61 | 15 | 16096 | 170543 | 50418470 |
Hyperreflexia | 19.93 | 13.61 | 15 | 16096 | 5103 | 50583910 |
Blood potassium increased | 19.39 | 13.61 | 25 | 16086 | 16373 | 50572640 |
Metabolic acidosis | 19.36 | 13.61 | 40 | 16071 | 38785 | 50550228 |
Hypertensive encephalopathy | 18.59 | 13.61 | 7 | 16104 | 577 | 50588436 |
Blood pressure decreased | 18.45 | 13.61 | 49 | 16062 | 55860 | 50533153 |
Oral discharge | 17.89 | 13.61 | 5 | 16106 | 158 | 50588855 |
Hepatic enzyme increased | 17.59 | 13.61 | 11 | 16100 | 137369 | 50451644 |
Malignant hypertension | 17.57 | 13.61 | 8 | 16103 | 1066 | 50587947 |
Angiosclerosis | 17.00 | 13.61 | 3 | 16108 | 9 | 50589004 |
Circulatory collapse | 16.96 | 13.61 | 26 | 16085 | 19974 | 50569039 |
Familial periodic paralysis | 16.96 | 13.61 | 4 | 16107 | 63 | 50588950 |
Dyspnoea | 16.90 | 13.61 | 256 | 15855 | 547352 | 50041661 |
Duodenal ulcer | 16.25 | 13.61 | 15 | 16096 | 6760 | 50582253 |
Swollen tongue | 16.08 | 13.61 | 31 | 16080 | 28599 | 50560414 |
Product dose omission issue | 16.05 | 13.61 | 21 | 16090 | 183817 | 50405196 |
Vision blurred | 15.79 | 13.61 | 58 | 16053 | 78589 | 50510424 |
Bradyphrenia | 15.50 | 13.61 | 14 | 16097 | 6138 | 50582875 |
Simple partial seizures | 15.41 | 13.61 | 6 | 16105 | 541 | 50588472 |
Therapeutic product effect incomplete | 15.34 | 13.61 | 5 | 16106 | 91510 | 50497503 |
Hypokalaemia | 15.31 | 13.61 | 62 | 16049 | 87930 | 50501083 |
Fasting | 15.05 | 13.61 | 3 | 16108 | 20 | 50588993 |
Discomfort | 14.83 | 13.61 | 8 | 16103 | 108372 | 50480641 |
Injection site erythema | 14.65 | 13.61 | 3 | 16108 | 74933 | 50514080 |
Gingival bleeding | 14.52 | 13.61 | 18 | 16093 | 11335 | 50577678 |
Muscle twitching | 14.43 | 13.61 | 21 | 16090 | 15410 | 50573603 |
Chronic kidney disease | 14.30 | 13.61 | 36 | 16075 | 39735 | 50549278 |
Heart rate decreased | 14.14 | 13.61 | 34 | 16077 | 36463 | 50552550 |
Nephrogenic anaemia | 14.07 | 13.61 | 8 | 16103 | 1697 | 50587316 |
Rheumatoid arthritis | 14.02 | 13.61 | 27 | 16084 | 202523 | 50386490 |
Pemphigoid | 14.02 | 13.61 | 13 | 16098 | 5894 | 50583119 |
Periorbital oedema | 13.81 | 13.61 | 12 | 16099 | 5000 | 50584013 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Syncope | 132.64 | 11.26 | 281 | 31900 | 81090 | 29461256 |
Orthostatic hypotension | 90.10 | 11.26 | 117 | 32064 | 22512 | 29519834 |
Off label use | 75.13 | 11.26 | 133 | 32048 | 300667 | 29241679 |
Hypertensive crisis | 73.49 | 11.26 | 64 | 32117 | 7784 | 29534562 |
Blood pressure inadequately controlled | 61.27 | 11.26 | 36 | 32145 | 2350 | 29539996 |
Middle insomnia | 58.45 | 11.26 | 49 | 32132 | 5659 | 29536687 |
Mycotic allergy | 56.77 | 11.26 | 18 | 32163 | 246 | 29542100 |
Febrile neutropenia | 54.52 | 11.26 | 27 | 32154 | 112213 | 29430133 |
Carotid arteriosclerosis | 54.34 | 11.26 | 28 | 32153 | 1410 | 29540936 |
Mite allergy | 53.54 | 11.26 | 18 | 32163 | 299 | 29542047 |
Asthma | 52.86 | 11.26 | 115 | 32066 | 33734 | 29508612 |
Full blood count abnormal | 51.18 | 11.26 | 72 | 32109 | 14941 | 29527405 |
Hypotension | 51.12 | 11.26 | 374 | 31807 | 193980 | 29348366 |
Conjunctivitis allergic | 50.92 | 11.26 | 21 | 32160 | 629 | 29541717 |
Spirometry abnormal | 50.48 | 11.26 | 18 | 32163 | 359 | 29541987 |
Dust allergy | 49.47 | 11.26 | 19 | 32162 | 470 | 29541876 |
Presyncope | 48.79 | 11.26 | 73 | 32108 | 16016 | 29526330 |
Drug interaction | 48.05 | 11.26 | 373 | 31808 | 197012 | 29345334 |
Drug abuse | 45.65 | 11.26 | 15 | 32166 | 79868 | 29462478 |
Left ventricular hypertrophy | 44.20 | 11.26 | 45 | 32136 | 6658 | 29535688 |
Hyperkalaemia | 44.09 | 11.26 | 157 | 32024 | 61235 | 29481111 |
Renal cyst haemorrhage | 41.92 | 11.26 | 16 | 32165 | 389 | 29541957 |
Bradycardia | 40.61 | 11.26 | 160 | 32021 | 65469 | 29476877 |
Productive cough | 39.78 | 11.26 | 98 | 32083 | 31161 | 29511185 |
Neutropenia | 39.76 | 11.26 | 51 | 32130 | 131660 | 29410686 |
Tricuspid valve incompetence | 37.52 | 11.26 | 46 | 32135 | 8348 | 29533998 |
Oedema peripheral | 36.75 | 11.26 | 215 | 31966 | 103342 | 29439004 |
Dizziness | 35.88 | 11.26 | 339 | 31842 | 189345 | 29353001 |
Blood creatinine increased | 35.76 | 11.26 | 185 | 31996 | 84917 | 29457429 |
Gastrointestinal tract mucosal pigmentation | 35.62 | 11.26 | 14 | 32167 | 369 | 29541977 |
Ventricular hyperkinesia | 35.49 | 11.26 | 12 | 32169 | 203 | 29542143 |
Loss of consciousness | 34.67 | 11.26 | 166 | 32015 | 73890 | 29468456 |
Hypertensive heart disease | 34.66 | 11.26 | 24 | 32157 | 2083 | 29540263 |
Right atrial enlargement | 34.24 | 11.26 | 12 | 32169 | 227 | 29542119 |
Atrial fibrillation | 32.85 | 11.26 | 212 | 31969 | 105434 | 29436912 |
Rectal prolapse | 32.77 | 11.26 | 12 | 32169 | 259 | 29542087 |
Mitral valve thickening | 32.48 | 11.26 | 13 | 32168 | 360 | 29541986 |
Aortic valve incompetence | 31.87 | 11.26 | 33 | 32148 | 4980 | 29537366 |
Renal artery stenosis | 31.47 | 11.26 | 22 | 32159 | 1939 | 29540407 |
Hypochromasia | 31.24 | 11.26 | 12 | 32169 | 297 | 29542049 |
SARS-CoV-2 antibody test positive | 30.73 | 11.26 | 11 | 32170 | 222 | 29542124 |
Mean platelet volume increased | 30.37 | 11.26 | 13 | 32168 | 428 | 29541918 |
Drug ineffective | 30.12 | 11.26 | 252 | 31929 | 362918 | 29179428 |
Nephrectomy | 29.91 | 11.26 | 15 | 32166 | 713 | 29541633 |
Death | 29.91 | 11.26 | 234 | 31947 | 341850 | 29200496 |
Mycobacterium test positive | 28.56 | 11.26 | 12 | 32169 | 377 | 29541969 |
Left ventricular enlargement | 28.46 | 11.26 | 14 | 32167 | 638 | 29541708 |
Subacute hepatic failure | 28.06 | 11.26 | 8 | 32173 | 74 | 29542272 |
Floppy iris syndrome | 27.77 | 11.26 | 11 | 32170 | 296 | 29542050 |
Vena cava injury | 27.65 | 11.26 | 10 | 32171 | 208 | 29542138 |
Wheezing | 27.35 | 11.26 | 89 | 32092 | 33151 | 29509195 |
Intraductal papillary mucinous neoplasm | 26.69 | 11.26 | 11 | 32170 | 329 | 29542017 |
Renal impairment | 26.38 | 11.26 | 165 | 32016 | 81168 | 29461178 |
Hyperparathyroidism | 26.20 | 11.26 | 16 | 32165 | 1121 | 29541225 |
Haemodialysis | 25.77 | 11.26 | 42 | 32139 | 9912 | 29532434 |
Myopathy | 25.33 | 11.26 | 43 | 32138 | 10490 | 29531856 |
Normochromic normocytic anaemia | 24.93 | 11.26 | 25 | 32156 | 3633 | 29538713 |
Primary hyperaldosteronism | 24.92 | 11.26 | 7 | 32174 | 61 | 29542285 |
Electrocardiogram T wave inversion | 24.38 | 11.26 | 19 | 32162 | 1978 | 29540368 |
Lung diffusion test decreased | 23.84 | 11.26 | 12 | 32169 | 575 | 29541771 |
Blood urea increased | 23.79 | 11.26 | 76 | 32105 | 28036 | 29514310 |
Left atrial enlargement | 23.76 | 11.26 | 13 | 32168 | 740 | 29541606 |
Septic shock | 23.61 | 11.26 | 20 | 32161 | 62540 | 29479806 |
Angioedema | 23.22 | 11.26 | 82 | 32099 | 31833 | 29510513 |
Vertigo | 23.16 | 11.26 | 64 | 32117 | 21797 | 29520549 |
Acute kidney injury | 23.13 | 11.26 | 411 | 31770 | 264856 | 29277490 |
Mitral valve incompetence | 22.87 | 11.26 | 47 | 32134 | 13246 | 29529100 |
Aortic dilatation | 22.87 | 11.26 | 14 | 32167 | 985 | 29541361 |
Tooth avulsion | 22.46 | 11.26 | 5 | 32176 | 14 | 29542332 |
Completed suicide | 22.33 | 11.26 | 40 | 32141 | 90206 | 29452140 |
Arteriosclerosis | 22.24 | 11.26 | 40 | 32141 | 10216 | 29532130 |
Bundle branch block left | 22.11 | 11.26 | 28 | 32153 | 5249 | 29537097 |
Orthopnoea | 22.03 | 11.26 | 26 | 32155 | 4534 | 29537812 |
Mucosal inflammation | 21.79 | 11.26 | 4 | 32177 | 31591 | 29510755 |
Nocturia | 21.26 | 11.26 | 35 | 32146 | 8327 | 29534019 |
Product use issue | 21.25 | 11.26 | 15 | 32166 | 51429 | 29490917 |
Treatment failure | 20.98 | 11.26 | 7 | 32174 | 36932 | 29505414 |
Cardiac autonomic neuropathy | 20.45 | 11.26 | 6 | 32175 | 62 | 29542284 |
Obstructive airways disorder | 20.20 | 11.26 | 40 | 32141 | 10976 | 29531370 |
Thrombocytopenia | 20.15 | 11.26 | 77 | 32104 | 134746 | 29407600 |
Hyperparathyroidism secondary | 19.75 | 11.26 | 14 | 32167 | 1261 | 29541085 |
Metabolic acidosis | 19.51 | 11.26 | 87 | 32094 | 37575 | 29504771 |
Urine flow decreased | 19.16 | 11.26 | 13 | 32168 | 1091 | 29541255 |
Hypertension | 18.90 | 11.26 | 202 | 31979 | 116412 | 29425934 |
Atrioventricular block first degree | 18.86 | 11.26 | 26 | 32155 | 5293 | 29537053 |
Atrioventricular block | 18.81 | 11.26 | 30 | 32151 | 6952 | 29535394 |
Shock hypoglycaemic | 18.05 | 11.26 | 6 | 32175 | 96 | 29542250 |
Scrotal oedema | 18.02 | 11.26 | 14 | 32167 | 1450 | 29540896 |
Sprue-like enteropathy | 17.88 | 11.26 | 9 | 32172 | 431 | 29541915 |
High density lipoprotein decreased | 17.85 | 11.26 | 19 | 32162 | 2960 | 29539386 |
Arteriosclerosis coronary artery | 17.66 | 11.26 | 37 | 32144 | 10568 | 29531778 |
Chronic kidney disease | 17.29 | 11.26 | 82 | 32099 | 36334 | 29506012 |
Angina pectoris | 17.29 | 11.26 | 68 | 32113 | 27782 | 29514564 |
Blood pressure ambulatory increased | 17.19 | 11.26 | 5 | 32176 | 50 | 29542296 |
Inappropriate schedule of product administration | 17.05 | 11.26 | 14 | 32167 | 44458 | 29497888 |
Human polyomavirus infection | 16.63 | 11.26 | 10 | 32171 | 681 | 29541665 |
Delayed graft function | 16.61 | 11.26 | 15 | 32166 | 1912 | 29540434 |
Haematuria | 16.51 | 11.26 | 93 | 32088 | 44046 | 29498300 |
Chronic obstructive pulmonary disease | 16.47 | 11.26 | 88 | 32093 | 40867 | 29501479 |
Psychotic symptom | 16.28 | 11.26 | 13 | 32168 | 1401 | 29540945 |
Benign prostatic hyperplasia | 16.27 | 11.26 | 38 | 32143 | 11672 | 29530674 |
Large intestine polyp | 16.22 | 11.26 | 27 | 32154 | 6482 | 29535864 |
Palpitations | 15.90 | 11.26 | 74 | 32107 | 32530 | 29509816 |
Abdominal wall haemorrhage | 15.85 | 11.26 | 7 | 32174 | 249 | 29542097 |
Drug monitoring procedure not performed | 15.74 | 11.26 | 7 | 32174 | 253 | 29542093 |
Xanthopsia | 15.71 | 11.26 | 6 | 32175 | 146 | 29542200 |
Hypoglycaemia | 15.61 | 11.26 | 98 | 32083 | 48248 | 29494098 |
Myocardial infarction | 15.57 | 11.26 | 186 | 31995 | 110110 | 29432236 |
Genital swelling | 15.45 | 11.26 | 6 | 32175 | 153 | 29542193 |
Crystalluria | 15.45 | 11.26 | 8 | 32173 | 407 | 29541939 |
Dilatation ventricular | 15.40 | 11.26 | 16 | 32165 | 2424 | 29539922 |
Diastolic dysfunction | 15.38 | 11.26 | 23 | 32158 | 5041 | 29537305 |
Spinal osteoarthritis | 15.35 | 11.26 | 26 | 32155 | 6330 | 29536016 |
Sepsis | 15.18 | 11.26 | 92 | 32089 | 142590 | 29399756 |
Product dose omission issue | 15.07 | 11.26 | 54 | 32127 | 96329 | 29446017 |
Pyrexia | 14.86 | 11.26 | 222 | 31959 | 287400 | 29254946 |
Renal cyst | 14.85 | 11.26 | 29 | 32152 | 7878 | 29534468 |
Dermatosis | 14.81 | 11.26 | 7 | 32174 | 292 | 29542054 |
Product use in unapproved indication | 14.72 | 11.26 | 47 | 32134 | 86828 | 29455518 |
Obstruction | 14.69 | 11.26 | 14 | 32167 | 1912 | 29540434 |
Spermatozoa progressive motility abnormal | 14.66 | 11.26 | 4 | 32177 | 31 | 29542315 |
Toxicity to various agents | 14.55 | 11.26 | 120 | 32061 | 173541 | 29368805 |
Supine hypertension | 14.52 | 11.26 | 7 | 32174 | 305 | 29542041 |
Electrocardiogram ST segment elevation | 14.51 | 11.26 | 21 | 32160 | 4471 | 29537875 |
Microalbuminuria | 14.37 | 11.26 | 9 | 32172 | 659 | 29541687 |
Infusion related reaction | 14.27 | 11.26 | 16 | 32165 | 43870 | 29498476 |
Aplasia pure red cell | 13.98 | 11.26 | 23 | 32158 | 5468 | 29536878 |
Asthenia | 13.88 | 11.26 | 319 | 31862 | 214931 | 29327415 |
Rhabdomyolysis | 13.68 | 11.26 | 113 | 32068 | 60695 | 29481651 |
Hospitalisation | 13.65 | 11.26 | 18 | 32163 | 45970 | 29496376 |
Ischaemic cardiomyopathy | 13.53 | 11.26 | 23 | 32158 | 5615 | 29536731 |
Duplicate therapy error | 13.48 | 11.26 | 5 | 32176 | 112 | 29542234 |
Blood phosphorus increased | 13.42 | 11.26 | 16 | 32165 | 2821 | 29539525 |
Melaena | 13.23 | 11.26 | 68 | 32113 | 31108 | 29511238 |
Malignant neoplasm progression | 13.20 | 11.26 | 39 | 32142 | 73820 | 29468526 |
Leukopenia | 13.17 | 11.26 | 25 | 32156 | 55178 | 29487168 |
Blood uric acid increased | 13.15 | 11.26 | 23 | 32158 | 5745 | 29536601 |
Multiple organ dysfunction syndrome | 13.04 | 11.26 | 31 | 32150 | 63085 | 29479261 |
Vitamin D decreased | 13.02 | 11.26 | 16 | 32165 | 2909 | 29539437 |
Renal failure | 13.00 | 11.26 | 191 | 31990 | 118408 | 29423938 |
Blood pressure increased | 12.96 | 11.26 | 130 | 32051 | 73673 | 29468673 |
Glomerular filtration rate decreased | 12.95 | 11.26 | 34 | 32147 | 11232 | 29531114 |
Respiratory failure | 12.92 | 11.26 | 58 | 32123 | 97073 | 29445273 |
Cardio-respiratory arrest | 12.90 | 11.26 | 22 | 32159 | 50579 | 29491767 |
Sinus node dysfunction | 12.86 | 11.26 | 18 | 32163 | 3716 | 29538630 |
Myalgia | 12.82 | 11.26 | 130 | 32051 | 73889 | 29468457 |
Spermatozoa progressive motility decreased | 12.75 | 11.26 | 5 | 32176 | 131 | 29542215 |
Disease progression | 12.74 | 11.26 | 46 | 32135 | 81870 | 29460476 |
Sinus rhythm | 12.50 | 11.26 | 6 | 32175 | 259 | 29542087 |
Toxic neuropathy | 12.48 | 11.26 | 7 | 32174 | 418 | 29541928 |
Blood pressure systolic decreased | 12.46 | 11.26 | 18 | 32163 | 3826 | 29538520 |
Blood chloride increased | 12.36 | 11.26 | 15 | 32166 | 2694 | 29539652 |
Aortic arteriosclerosis | 12.34 | 11.26 | 18 | 32163 | 3858 | 29538488 |
Myopathy toxic | 12.30 | 11.26 | 7 | 32174 | 430 | 29541916 |
Post transplant distal limb syndrome | 12.03 | 11.26 | 6 | 32175 | 282 | 29542064 |
Jaundice hepatocellular | 11.98 | 11.26 | 4 | 32177 | 65 | 29542281 |
Chronic fatigue syndrome | 11.89 | 11.26 | 6 | 32175 | 289 | 29542057 |
Pneumonia | 11.84 | 11.26 | 262 | 31919 | 319910 | 29222436 |
Blood potassium increased | 11.84 | 11.26 | 39 | 32142 | 14612 | 29527734 |
Haemoglobinaemia | 11.79 | 11.26 | 5 | 32176 | 161 | 29542185 |
Mean cell volume increased | 11.71 | 11.26 | 14 | 32167 | 2475 | 29539871 |
Cerebral haemorrhage | 11.61 | 11.26 | 66 | 32115 | 31360 | 29510986 |
Vascular compression | 11.59 | 11.26 | 5 | 32176 | 168 | 29542178 |
Agitation | 11.58 | 11.26 | 24 | 32157 | 51280 | 29491066 |
Diverticulum intestinal | 11.54 | 11.26 | 16 | 32165 | 3274 | 29539072 |
Tongue haemorrhage | 11.48 | 11.26 | 7 | 32174 | 489 | 29541857 |
Mouth breathing | 11.45 | 11.26 | 4 | 32177 | 75 | 29542271 |
Breath sounds | 11.38 | 11.26 | 3 | 32178 | 20 | 29542326 |
Eosinophilia | 11.33 | 11.26 | 51 | 32130 | 22110 | 29520236 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Syncope | 229.43 | 11.03 | 388 | 41923 | 157247 | 64299174 |
Hypertensive crisis | 185.07 | 11.03 | 127 | 42184 | 18121 | 64438300 |
Hyperkalaemia | 180.05 | 11.03 | 273 | 42038 | 100856 | 64355565 |
Drug interaction | 144.61 | 11.03 | 543 | 41768 | 361540 | 64094881 |
Hypotension | 142.06 | 11.03 | 559 | 41752 | 380415 | 64076006 |
Orthostatic hypotension | 140.21 | 11.03 | 163 | 42148 | 46575 | 64409846 |
Acute kidney injury | 99.63 | 11.03 | 567 | 41744 | 448673 | 64007748 |
Bradycardia | 86.14 | 11.03 | 219 | 42092 | 118000 | 64338421 |
Off label use | 85.37 | 11.03 | 180 | 42131 | 632626 | 63823795 |
Renal impairment | 80.22 | 11.03 | 232 | 42079 | 134785 | 64321636 |
Rectal prolapse | 76.07 | 11.03 | 32 | 42279 | 1694 | 64454727 |
Presyncope | 69.98 | 11.03 | 100 | 42211 | 34989 | 64421432 |
Blood pressure inadequately controlled | 68.02 | 11.03 | 43 | 42268 | 5341 | 64451080 |
Carotid arteriosclerosis | 64.10 | 11.03 | 30 | 42281 | 2049 | 64454372 |
Renal artery stenosis | 59.53 | 11.03 | 32 | 42279 | 2937 | 64453484 |
Atrial fibrillation | 58.71 | 11.03 | 245 | 42066 | 170844 | 64285577 |
Blood creatinine increased | 58.50 | 11.03 | 209 | 42102 | 135573 | 64320848 |
Middle insomnia | 58.40 | 11.03 | 56 | 42255 | 12821 | 64443600 |
Dizziness | 57.10 | 11.03 | 479 | 41832 | 429684 | 64026737 |
Drug ineffective | 55.66 | 11.03 | 324 | 41987 | 839923 | 63616498 |
Angioedema | 54.11 | 11.03 | 123 | 42188 | 61698 | 64394723 |
Alopecia | 53.26 | 11.03 | 21 | 42290 | 165669 | 64290752 |
Hyponatraemia | 52.91 | 11.03 | 215 | 42096 | 148124 | 64308297 |
Febrile neutropenia | 52.28 | 11.03 | 29 | 42282 | 187628 | 64268793 |
Loss of consciousness | 51.31 | 11.03 | 213 | 42098 | 148152 | 64308269 |
Hypoglycaemia | 51.00 | 11.03 | 152 | 42159 | 89740 | 64366681 |
Oedema peripheral | 50.81 | 11.03 | 272 | 42039 | 210045 | 64246376 |
Left ventricular hypertrophy | 50.19 | 11.03 | 45 | 42266 | 9461 | 64446960 |
Conjunctivitis allergic | 48.44 | 11.03 | 20 | 42291 | 1010 | 64455411 |
Treatment failure | 48.41 | 11.03 | 9 | 42302 | 116807 | 64339614 |
Spirometry abnormal | 48.09 | 11.03 | 17 | 42294 | 559 | 64455862 |
Renal cyst haemorrhage | 47.77 | 11.03 | 16 | 42295 | 446 | 64455975 |
Contraindicated product administered | 47.59 | 11.03 | 7 | 42304 | 107822 | 64348599 |
Product use issue | 47.51 | 11.03 | 20 | 42291 | 151695 | 64304726 |
Full blood count abnormal | 46.86 | 11.03 | 76 | 42235 | 29681 | 64426740 |
Blood urea increased | 46.86 | 11.03 | 95 | 42216 | 44058 | 64412363 |
Bladder prolapse | 46.46 | 11.03 | 20 | 42291 | 1121 | 64455300 |
Drug intolerance | 45.61 | 11.03 | 34 | 42277 | 187958 | 64268463 |
Maternal exposure during pregnancy | 45.28 | 11.03 | 5 | 42306 | 95879 | 64360542 |
Pain | 44.75 | 11.03 | 199 | 42112 | 553312 | 63903109 |
Mite allergy | 44.32 | 11.03 | 17 | 42294 | 706 | 64455715 |
Metabolic acidosis | 43.14 | 11.03 | 123 | 42188 | 70835 | 64385586 |
Renal failure | 42.53 | 11.03 | 233 | 42078 | 181455 | 64274966 |
Dust allergy | 41.38 | 11.03 | 18 | 42293 | 1035 | 64455386 |
Mycotic allergy | 39.02 | 11.03 | 17 | 42294 | 981 | 64455440 |
Ventricular hyperkinesia | 38.64 | 11.03 | 12 | 42299 | 261 | 64456160 |
Sinusitis | 38.59 | 11.03 | 24 | 42287 | 145904 | 64310517 |
Mitral valve thickening | 37.97 | 11.03 | 13 | 42298 | 388 | 64456033 |
Vitamin D decreased | 37.86 | 11.03 | 35 | 42276 | 7652 | 64448769 |
Neutropenia | 37.62 | 11.03 | 62 | 42249 | 239562 | 64216859 |
Glomerular filtration rate decreased | 36.43 | 11.03 | 54 | 42257 | 19518 | 64436903 |
Right atrial enlargement | 36.22 | 11.03 | 12 | 42299 | 323 | 64456098 |
Tricuspid valve incompetence | 36.18 | 11.03 | 50 | 42261 | 16953 | 64439468 |
Aortic valve incompetence | 35.58 | 11.03 | 35 | 42276 | 8266 | 64448155 |
SARS-CoV-2 antibody test positive | 35.47 | 11.03 | 11 | 42300 | 238 | 64456183 |
Hypertensive heart disease | 35.11 | 11.03 | 25 | 42286 | 3779 | 64452642 |
Therapeutic product effect decreased | 34.85 | 11.03 | 16 | 42295 | 115335 | 64341086 |
Left ventricular enlargement | 34.62 | 11.03 | 14 | 42297 | 670 | 64455751 |
Productive cough | 34.38 | 11.03 | 116 | 42195 | 73087 | 64383334 |
Arteriosclerosis | 34.25 | 11.03 | 47 | 42264 | 15830 | 64440591 |
Mycobacterium test positive | 33.73 | 11.03 | 12 | 42299 | 402 | 64456019 |
Mitral valve incompetence | 33.32 | 11.03 | 60 | 42251 | 25478 | 64430943 |
Cardiac failure | 33.17 | 11.03 | 173 | 42138 | 132200 | 64324221 |
Benign prostatic hyperplasia | 32.68 | 11.03 | 35 | 42276 | 9130 | 64447291 |
Hepatic enzyme increased | 32.16 | 11.03 | 23 | 42288 | 129920 | 64326501 |
Systemic lupus erythematosus | 32.11 | 11.03 | 6 | 42305 | 77606 | 64378815 |
Vena cava injury | 32.09 | 11.03 | 10 | 42301 | 220 | 64456201 |
Rheumatoid arthritis | 31.28 | 11.03 | 37 | 42274 | 164257 | 64292164 |
Gastrointestinal tract mucosal pigmentation | 30.52 | 11.03 | 14 | 42297 | 913 | 64455508 |
Nephrectomy | 30.41 | 11.03 | 16 | 42295 | 1406 | 64455015 |
Sopor | 29.33 | 11.03 | 62 | 42249 | 29599 | 64426822 |
Chronic kidney disease | 29.18 | 11.03 | 94 | 42217 | 57825 | 64398596 |
Arthropathy | 29.17 | 11.03 | 22 | 42289 | 120945 | 64335476 |
Completed suicide | 29.16 | 11.03 | 65 | 42246 | 224349 | 64232072 |
Product dose omission issue | 29.08 | 11.03 | 52 | 42259 | 194695 | 64261726 |
Hypochromasia | 28.30 | 11.03 | 12 | 42299 | 648 | 64455773 |
Primary hyperaldosteronism | 28.00 | 11.03 | 8 | 42303 | 129 | 64456292 |
Melaena | 27.98 | 11.03 | 88 | 42223 | 53460 | 64402961 |
Blood pressure increased | 27.70 | 11.03 | 201 | 42110 | 172351 | 64284070 |
Gallbladder polyp | 27.62 | 11.03 | 13 | 42298 | 899 | 64455522 |
Scrotal oedema | 27.01 | 11.03 | 14 | 42297 | 1193 | 64455228 |
Mean platelet volume increased | 26.76 | 11.03 | 13 | 42298 | 965 | 64455456 |
Pemphigus | 26.64 | 11.03 | 4 | 42307 | 60697 | 64395724 |
Rhabdomyolysis | 26.61 | 11.03 | 125 | 42186 | 91601 | 64364820 |
Blood potassium increased | 26.50 | 11.03 | 55 | 42256 | 25925 | 64430496 |
Sinus bradycardia | 26.39 | 11.03 | 51 | 42260 | 22842 | 64433579 |
Circulatory collapse | 26.12 | 11.03 | 64 | 42247 | 33668 | 64422753 |
Intraductal papillary mucinous neoplasm | 26.08 | 11.03 | 11 | 42300 | 586 | 64455835 |
Cardiac failure congestive | 25.69 | 11.03 | 160 | 42151 | 130420 | 64326001 |
Nocturia | 25.53 | 11.03 | 34 | 42277 | 11131 | 64445290 |
Abdominal discomfort | 25.19 | 11.03 | 51 | 42260 | 182271 | 64274150 |
Asthenia | 25.06 | 11.03 | 407 | 41904 | 427637 | 64028784 |
Injection site inflammation | 24.85 | 11.03 | 19 | 42292 | 3202 | 64453219 |
Infusion related reaction | 24.47 | 11.03 | 44 | 42267 | 164423 | 64291998 |
Subacute hepatic failure | 24.45 | 11.03 | 8 | 42303 | 207 | 64456214 |
Angina pectoris | 24.39 | 11.03 | 75 | 42236 | 45006 | 64411415 |
Floppy iris syndrome | 24.38 | 11.03 | 9 | 42302 | 336 | 64456085 |
Ischaemic cardiomyopathy | 24.18 | 11.03 | 26 | 42285 | 6812 | 64449609 |
Nasopharyngitis | 23.70 | 11.03 | 59 | 42252 | 196014 | 64260407 |
Blood uric acid increased | 23.68 | 11.03 | 28 | 42283 | 8135 | 64448286 |
Haemodialysis | 23.41 | 11.03 | 41 | 42270 | 17036 | 64439385 |
Urine flow decreased | 23.34 | 11.03 | 12 | 42299 | 1005 | 64455416 |
Left atrial enlargement | 23.18 | 11.03 | 12 | 42299 | 1020 | 64455401 |
Wheezing | 22.78 | 11.03 | 109 | 42202 | 80470 | 64375951 |
Orthopnoea | 22.73 | 11.03 | 29 | 42282 | 9105 | 64447316 |
Injection site erythema | 22.69 | 11.03 | 9 | 42302 | 70791 | 64385630 |
Arteriosclerosis coronary artery | 22.22 | 11.03 | 38 | 42273 | 15491 | 64440930 |
Haematuria | 21.81 | 11.03 | 88 | 42223 | 60383 | 64396038 |
Swollen tongue | 21.63 | 11.03 | 61 | 42250 | 34893 | 64421528 |
Lung diffusion test decreased | 21.52 | 11.03 | 12 | 42299 | 1184 | 64455237 |
Hypertension | 21.39 | 11.03 | 262 | 42049 | 258999 | 64197422 |
Obstructive airways disorder | 21.25 | 11.03 | 47 | 42264 | 23138 | 64433283 |
Normochromic normocytic anaemia | 21.17 | 11.03 | 24 | 42287 | 6666 | 64449755 |
End stage renal disease | 21.09 | 11.03 | 30 | 42281 | 10445 | 64445976 |
Coronary artery disease | 21.05 | 11.03 | 87 | 42224 | 60346 | 64396075 |
Dermatosis | 21.03 | 11.03 | 9 | 42302 | 497 | 64455924 |
Death | 20.96 | 11.03 | 209 | 42102 | 482496 | 63973925 |
Sinus node dysfunction | 20.77 | 11.03 | 24 | 42287 | 6804 | 64449617 |
Chronic obstructive pulmonary disease | 20.73 | 11.03 | 97 | 42214 | 70951 | 64385470 |
Atrioventricular block | 20.73 | 11.03 | 32 | 42279 | 11983 | 64444438 |
Angiosclerosis | 20.61 | 11.03 | 4 | 42307 | 9 | 64456412 |
Bundle branch block left | 20.59 | 11.03 | 29 | 42282 | 10005 | 64446416 |
Myocardial infarction | 20.52 | 11.03 | 182 | 42129 | 165639 | 64290782 |
Discomfort | 20.42 | 11.03 | 14 | 42297 | 80864 | 64375557 |
Mucosal membrane hyperplasia | 20.27 | 11.03 | 5 | 42306 | 44 | 64456377 |
Exposure during pregnancy | 20.21 | 11.03 | 13 | 42298 | 77662 | 64378759 |
Hyperparathyroidism | 20.21 | 11.03 | 16 | 42295 | 2836 | 64453585 |
Tubulointerstitial nephritis | 20.17 | 11.03 | 55 | 42256 | 30854 | 64425567 |
Product use in unapproved indication | 19.93 | 11.03 | 55 | 42256 | 176563 | 64279858 |
Myopathy | 19.90 | 11.03 | 39 | 42272 | 17641 | 64438780 |
Infection | 19.81 | 11.03 | 59 | 42252 | 184821 | 64271600 |
Cerebral haemorrhage | 19.76 | 11.03 | 76 | 42235 | 51014 | 64405407 |
Drug monitoring procedure not performed | 19.74 | 11.03 | 10 | 42301 | 812 | 64455609 |
Aortic dilatation | 19.74 | 11.03 | 12 | 42299 | 1391 | 64455030 |
Blood pressure ambulatory increased | 19.60 | 11.03 | 5 | 42306 | 51 | 64456370 |
Cardiac autonomic neuropathy | 19.60 | 11.03 | 5 | 42306 | 51 | 64456370 |
High density lipoprotein decreased | 19.50 | 11.03 | 18 | 42293 | 3928 | 64452493 |
Glossodynia | 19.50 | 11.03 | 9 | 42302 | 64687 | 64391734 |
Dyspnoea | 19.37 | 11.03 | 612 | 41699 | 718062 | 63738359 |
Abdominal wall haemorrhage | 19.13 | 11.03 | 8 | 42303 | 417 | 64456004 |
Hypokalaemia | 18.98 | 11.03 | 141 | 42170 | 121762 | 64334659 |
Large intestine polyp | 18.89 | 11.03 | 29 | 42282 | 10808 | 64445613 |
Kidney transplant rejection | 18.80 | 11.03 | 27 | 42284 | 9484 | 64446937 |
Thermal burn | 18.37 | 11.03 | 21 | 42290 | 5885 | 64450536 |
Renal cyst | 18.30 | 11.03 | 31 | 42280 | 12539 | 64443882 |
Nausea | 17.74 | 11.03 | 387 | 41924 | 785413 | 63671008 |
Urinary incontinence | 17.60 | 11.03 | 58 | 42253 | 36093 | 64420328 |
Post cardiac arrest syndrome | 17.55 | 11.03 | 4 | 42307 | 24 | 64456397 |
Psychotic symptom | 17.35 | 11.03 | 13 | 42298 | 2125 | 64454296 |
Delayed graft function | 17.28 | 11.03 | 15 | 42296 | 3021 | 64453400 |
Rectal haemorrhage | 17.02 | 11.03 | 83 | 42228 | 61734 | 64394687 |
Rash | 16.92 | 11.03 | 206 | 42105 | 458343 | 63998078 |
Flushing | 16.88 | 11.03 | 16 | 42295 | 78632 | 64377789 |
Acute myocardial infarction | 16.68 | 11.03 | 90 | 42221 | 69628 | 64386793 |
Spermatozoa progressive motility abnormal | 16.66 | 11.03 | 4 | 42307 | 31 | 64456390 |
Stomatitis | 16.59 | 11.03 | 29 | 42282 | 109576 | 64346845 |
Blood chloride increased | 16.52 | 11.03 | 18 | 42293 | 4785 | 64451636 |
Cerebrovascular accident | 16.50 | 11.03 | 150 | 42161 | 137433 | 64318988 |
Electrocardiogram ST segment elevation | 16.43 | 11.03 | 22 | 42289 | 7237 | 64449184 |
Renin increased | 16.40 | 11.03 | 6 | 42305 | 218 | 64456203 |
Hyperparathyroidism secondary | 16.36 | 11.03 | 13 | 42298 | 2317 | 64454104 |
Muscular dystrophy | 16.35 | 11.03 | 5 | 42306 | 103 | 64456318 |
Electrocardiogram T wave inversion | 16.24 | 11.03 | 18 | 42293 | 4876 | 64451545 |
Fasting | 16.23 | 11.03 | 4 | 42307 | 35 | 64456386 |
Nephrogenic anaemia | 16.11 | 11.03 | 15 | 42296 | 3310 | 64453111 |
Haemoglobin decreased | 16.02 | 11.03 | 197 | 42114 | 194866 | 64261555 |
Drug abuse | 15.86 | 11.03 | 40 | 42271 | 132334 | 64324087 |
Joint swelling | 15.83 | 11.03 | 80 | 42231 | 215302 | 64241119 |
Shock hypoglycaemic | 15.76 | 11.03 | 6 | 42305 | 244 | 64456177 |
Priapism | 15.65 | 11.03 | 16 | 42295 | 3954 | 64452467 |
Simple partial seizures | 15.64 | 11.03 | 8 | 42303 | 663 | 64455758 |
Erectile dysfunction | 15.63 | 11.03 | 29 | 42282 | 12598 | 64443823 |
Injection site pruritus | 15.48 | 11.03 | 3 | 42308 | 37823 | 64418598 |
Vertigo | 15.38 | 11.03 | 78 | 42233 | 58933 | 64397488 |
Human polyomavirus infection | 15.07 | 11.03 | 9 | 42302 | 1010 | 64455411 |
Eosinophilia | 15.02 | 11.03 | 57 | 42254 | 38019 | 64418402 |
Atrioventricular block first degree | 15.01 | 11.03 | 26 | 42285 | 10708 | 64445713 |
Sprue-like enteropathy | 14.99 | 11.03 | 9 | 42302 | 1020 | 64455401 |
Prostatic haemorrhage | 14.77 | 11.03 | 5 | 42306 | 144 | 64456277 |
Asthma | 14.74 | 11.03 | 110 | 42201 | 95115 | 64361306 |
Anuria | 14.70 | 11.03 | 36 | 42275 | 18928 | 64437493 |
Clonus | 14.68 | 11.03 | 19 | 42292 | 6048 | 64450373 |
Obstruction | 14.49 | 11.03 | 14 | 42297 | 3234 | 64453187 |
Genital swelling | 14.44 | 11.03 | 6 | 42305 | 308 | 64456113 |
Blood phosphorus increased | 14.40 | 11.03 | 17 | 42294 | 4929 | 64451492 |
Gastrointestinal disorder | 14.26 | 11.03 | 23 | 42288 | 89686 | 64366735 |
Spermatozoa progressive motility decreased | 14.21 | 11.03 | 4 | 42307 | 61 | 64456360 |
Arthralgia | 14.01 | 11.03 | 205 | 42106 | 442055 | 64014366 |
Crystalluria | 13.97 | 11.03 | 8 | 42303 | 830 | 64455591 |
Electrocardiogram T wave peaked | 13.93 | 11.03 | 8 | 42303 | 835 | 64455586 |
Herpes zoster | 13.85 | 11.03 | 19 | 42292 | 79168 | 64377253 |
Aortic valve sclerosis | 13.71 | 11.03 | 10 | 42301 | 1569 | 64454852 |
Tooth avulsion | 13.64 | 11.03 | 4 | 42307 | 71 | 64456350 |
Supine hypertension | 13.63 | 11.03 | 6 | 42305 | 355 | 64456066 |
Ventricular hypertrophy | 13.62 | 11.03 | 19 | 42292 | 6497 | 64449924 |
Nephrogenic systemic fibrosis | 13.56 | 11.03 | 18 | 42293 | 5874 | 64450547 |
Ill-defined disorder | 13.47 | 11.03 | 6 | 42305 | 44046 | 64412375 |
Therapeutic product effect incomplete | 13.40 | 11.03 | 30 | 42281 | 103452 | 64352969 |
Feeling cold | 13.38 | 11.03 | 40 | 42271 | 23638 | 64432783 |
Septic shock | 13.31 | 11.03 | 31 | 42280 | 105406 | 64351015 |
Injection site reaction | 13.29 | 11.03 | 7 | 42304 | 46657 | 64409764 |
Chills | 13.17 | 11.03 | 46 | 42265 | 137218 | 64319203 |
Hyperlipidaemia | 13.16 | 11.03 | 39 | 42272 | 22937 | 64433484 |
Bronchiolitis | 13.15 | 11.03 | 14 | 42297 | 3627 | 64452794 |
Duplicate therapy error | 13.14 | 11.03 | 5 | 42306 | 203 | 64456218 |
Toxicity to various agents | 13.14 | 11.03 | 164 | 42147 | 363349 | 64093072 |
Vascular anastomotic haemorrhage | 13.01 | 11.03 | 4 | 42307 | 84 | 64456337 |
Myalgia | 12.93 | 11.03 | 160 | 42151 | 158457 | 64297964 |
Perineal cyst | 12.92 | 11.03 | 4 | 42307 | 86 | 64456335 |
Diabetic nephropathy | 12.91 | 11.03 | 12 | 42299 | 2642 | 64453779 |
Fatigue | 12.79 | 11.03 | 384 | 41927 | 748346 | 63708075 |
Oliguria | 12.74 | 11.03 | 29 | 42282 | 14547 | 64441874 |
Angina unstable | 12.67 | 11.03 | 30 | 42281 | 15437 | 64440984 |
Disease progression | 12.60 | 11.03 | 49 | 42262 | 141631 | 64314790 |
Aplasia pure red cell | 12.55 | 11.03 | 19 | 42292 | 6995 | 64449426 |
Shock | 12.50 | 11.03 | 54 | 42257 | 38186 | 64418235 |
Condition aggravated | 12.37 | 11.03 | 171 | 42140 | 372255 | 64084166 |
Blood glucose increased | 12.30 | 11.03 | 108 | 42203 | 97965 | 64358456 |
Ventricular extrasystoles | 12.26 | 11.03 | 32 | 42279 | 17497 | 64438924 |
Bundle branch block | 12.23 | 11.03 | 9 | 42302 | 1431 | 64454990 |
Anaemia | 12.21 | 11.03 | 330 | 41981 | 378350 | 64078071 |
Oral discharge | 12.06 | 11.03 | 5 | 42306 | 255 | 64456166 |
Haemoglobinaemia | 12.04 | 11.03 | 5 | 42306 | 256 | 64456165 |
Multiple sclerosis relapse | 11.97 | 11.03 | 6 | 42305 | 41129 | 64415292 |
Vascular compression | 11.77 | 11.03 | 5 | 42306 | 271 | 64456150 |
Duodenal ulcer perforation | 11.77 | 11.03 | 4 | 42307 | 34621 | 64421800 |
Periorbital oedema | 11.76 | 11.03 | 19 | 42292 | 7395 | 64449026 |
Tachyarrhythmia | 11.75 | 11.03 | 17 | 42294 | 6009 | 64450412 |
Jaundice hepatocellular | 11.70 | 11.03 | 4 | 42307 | 119 | 64456302 |
Toxic neuropathy | 11.69 | 11.03 | 7 | 42304 | 789 | 64455632 |
Coronary artery stenosis | 11.69 | 11.03 | 24 | 42287 | 11224 | 64445197 |
Ejaculation disorder | 11.68 | 11.03 | 6 | 42305 | 502 | 64455919 |
Aortic arteriosclerosis | 11.64 | 11.03 | 19 | 42292 | 7457 | 64448964 |
Optic neuropathy | 11.63 | 11.03 | 12 | 42299 | 2999 | 64453422 |
Daydreaming | 11.58 | 11.03 | 7 | 42304 | 803 | 64455618 |
Blood lactic acid abnormal | 11.56 | 11.03 | 3 | 42308 | 33 | 64456388 |
Neuropathy peripheral | 11.54 | 11.03 | 39 | 42272 | 117486 | 64338935 |
Cardiomegaly | 11.53 | 11.03 | 38 | 42273 | 23646 | 64432775 |
Anti-erythropoietin antibody negative | 11.49 | 11.03 | 5 | 42306 | 288 | 64456133 |
Post transplant distal limb syndrome | 11.44 | 11.03 | 6 | 42305 | 524 | 64455897 |
Proteinuria | 11.35 | 11.03 | 42 | 42269 | 27681 | 64428740 |
Mouth breathing | 11.33 | 11.03 | 4 | 42307 | 131 | 64456290 |
Lactic acidosis | 11.30 | 11.03 | 74 | 42237 | 61336 | 64395085 |
Phaeochromocytoma crisis | 11.26 | 11.03 | 5 | 42306 | 302 | 64456119 |
Hepatocellular injury | 11.19 | 11.03 | 8 | 42303 | 45227 | 64411194 |
Tongue haemorrhage | 11.17 | 11.03 | 7 | 42304 | 856 | 64455565 |
Xanthopsia | 11.17 | 11.03 | 5 | 42306 | 308 | 64456113 |
Sepsis | 11.14 | 11.03 | 97 | 42214 | 230244 | 64226177 |
Haemorrhage subcutaneous | 11.09 | 11.03 | 14 | 42297 | 4347 | 64452074 |
Folliculitis | 11.08 | 11.03 | 3 | 42308 | 30074 | 64426347 |
Gravitational oedema | 11.04 | 11.03 | 9 | 42302 | 1663 | 64454758 |
None
Source | Code | Description |
---|---|---|
ATC | C02CA04 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING Alpha-adrenoreceptor antagonists |
FDA MoA | N0000000099 | Adrenergic alpha-Antagonists |
FDA EPC | N0000175553 | alpha-Adrenergic Blocker |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:37890 | alpha-adrenergic receptor blockaders |
CHEBI has role | CHEBI:59844 | antihyperplasia drugs |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D058668 | Adrenergic alpha-1 Receptor Antagonists |
MeSH PA | D000317 | Adrenergic alpha-Antagonists |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Benign prostatic hyperplasia | indication | 266569009 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Stenosis of intestine | contraindication | 23065003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Low blood pressure | contraindication | 45007003 | |
Hepatic failure | contraindication | 59927004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cataract surgery | contraindication | 110473004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pyloric obstruction | contraindication | 244815007 | |
Syncope | contraindication | 271594007 | |
Intraoperative floppy iris syndrome | contraindication | 418801006 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.22 | Basic |
pKa2 | 0.72 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-1D adrenergic receptor | GPCR | ANTAGONIST | Ki | 8.85 | WOMBAT-PK | CHEMBL | |||
Alpha-1B adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.10 | WOMBAT-PK | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | ANTAGONIST | Ki | 8.80 | WOMBAT-PK | CHEMBL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 6.23 | WOMBAT-PK | |||||
Multidrug resistance protein 1 | Transporter | Ki | 5 | WOMBAT-PK | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 5.85 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.63 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.55 | DRUG MATRIX | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.55 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 6.83 | DRUG MATRIX | |||||
Interstitial collagenase | Enzyme | IC50 | 5.24 | DRUG MATRIX | |||||
HLA class I histocompatibility antigen, A-3 alpha chain | Unclassified | Kd | 4.80 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.72 | DRUG MATRIX | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.14 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 9.38 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 8.81 | CHEMBL | |||||
5-hydroxytryptamine receptor 4 | GPCR | Ki | 6.90 | DRUG MATRIX |
ID | Source |
---|---|
4019735 | VUID |
N0000147827 | NUI |
D00608 | KEGG_DRUG |
77883-43-3 | SECONDARY_CAS_RN |
4019565 | VANDF |
4019735 | VANDF |
C0114873 | UMLSCUI |
CHEBI:4708 | CHEBI |
CHEMBL707 | ChEMBL_ID |
CHEMBL1200561 | ChEMBL_ID |
D017292 | MESH_DESCRIPTOR_UI |
DB00590 | DRUGBANK_ID |
7170 | IUPHAR_LIGAND_ID |
5143 | INN_ID |
NW1291F1W8 | UNII |
3157 | PUBCHEM_CID |
39173 | RXNORM |
37806 | MMSL |
40546 | MMSL |
4637 | MMSL |
d00726 | MMSL |
003561 | NDDF |
004493 | NDDF |
108556006 | SNOMEDCT_US |
108557002 | SNOMEDCT_US |
372508002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2040 | TABLET, MULTILAYER, EXTENDED RELEASE | 4 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2040 | TABLET, MULTILAYER, EXTENDED RELEASE | 4 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2080 | TABLET, MULTILAYER, EXTENDED RELEASE | 8 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2080 | TABLET, MULTILAYER, EXTENDED RELEASE | 8 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2410 | TABLET | 1 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2512 | TABLET | 2 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2614 | TABLET | 4 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2710 | TABLET, MULTILAYER, EXTENDED RELEASE | 4 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2710 | TABLET, MULTILAYER, EXTENDED RELEASE | 4 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2716 | TABLET | 8 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2720 | TABLET, MULTILAYER, EXTENDED RELEASE | 8 mg | ORAL | NDA | 28 sections |
Cardura XL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2720 | TABLET, MULTILAYER, EXTENDED RELEASE | 8 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2750 | TABLET | 1 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2760 | TABLET | 2 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2770 | TABLET | 4 mg | ORAL | NDA | 28 sections |
Cardura | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0049-2780 | TABLET | 8 mg | ORAL | NDA | 28 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2067 | TABLET | 8 mg | ORAL | ANDA | 26 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2068 | TABLET | 4 mg | ORAL | ANDA | 26 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2069 | TABLET | 2 mg | ORAL | ANDA | 26 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2070 | TABLET | 1 mg | ORAL | ANDA | 26 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0356 | TABLET | 1 mg | ORAL | ANDA | 28 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0357 | TABLET | 2 mg | ORAL | ANDA | 28 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1358 | TABLET | 4 mg | ORAL | ANDA | 28 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1359 | TABLET | 8 mg | ORAL | ANDA | 28 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5522 | TABLET | 1 mg | ORAL | ANDA | 18 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5523 | TABLET | 2 mg | ORAL | ANDA | 18 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5524 | TABLET | 4 mg | ORAL | ANDA | 18 sections |
Doxazosin Mesylate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-292 | TABLET | 4 mg | ORAL | ANDA | 24 sections |
Doxazosin Mesylate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-629 | TABLET | 1 mg | ORAL | ANDA | 24 sections |
Doxazosin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-274 | TABLET | 4 mg | ORAL | ANDA | 12 sections |