isopropanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4215	67-63-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: isopropyl alcohol 2-Propanol iso-Propanol isopropanol	An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic. Molecular weight: 60.10 Formula: C3H8O CLOGP: 0.07 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: 0.80 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

isopropyl alcohol
2-Propanol
iso-Propanol
isopropanol

An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

Molecular weight: 60.10
Formula: C3H8O
CLOGP: 0.07
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: 0.80
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	5286.39	17.65	2274	35846	143399	63307503
Toxicity to various agents	2927.30	17.65	1820	36300	245430	63205472
Drug abuse	1695.09	17.65	839	37281	71679	63379223
Cardio-respiratory arrest	994.48	17.65	552	37568	59407	63391495
Intentional overdose	872.98	17.65	547	37573	73605	63377297
Overdose	609.45	17.65	524	37596	114554	63336348
Suicide attempt	540.59	17.65	377	37743	60541	63390361
Alcohol interaction	438.52	17.65	126	37994	2283	63448619
Suspected suicide	367.50	17.65	141	37979	6427	63444475
Respiratory arrest	268.41	17.65	193	37927	32452	63418450

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	5530.33	18.01	2233	23995	96863	34833840
Completed suicide	3951.66	18.01	1759	24469	96409	34834294
Toxicity to various agents	3554.33	18.01	2060	24168	198302	34732401
Cardio-respiratory arrest	818.02	18.01	511	25717	54762	34875941
Intentional overdose	772.93	18.01	453	25775	43221	34887482
Overdose	630.28	18.01	531	25697	90528	34840175
Alcohol abuse	548.19	18.01	184	26044	4506	34926197
Intentional product misuse	521.06	18.01	359	25869	45252	34885451
Alcohol interaction	512.44	18.01	156	26072	2757	34927946
Suicide attempt	451.63	18.01	310	25918	38806	34891897

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	8999.98	16.07	3985	49684	241782	79448937
Drug abuse	6979.39	16.07	2958	50711	159733	79530986
Toxicity to various agents	6393.36	16.07	3774	49895	417766	79272953
Cardio-respiratory arrest	1836.34	16.07	1052	52617	107458	79583261
Intentional overdose	1403.70	16.07	878	52791	105082	79585637
Overdose	1061.97	16.07	924	52745	183282	79507437
Alcohol interaction	811.28	16.07	244	53425	4630	79686089
Intentional product misuse	729.33	16.07	564	53105	94601	79596118
Suspected suicide	690.43	16.07	262	53407	10314	79680405
Suicide attempt	642.97	16.07	495	53174	82437	79608282

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	D08AX05	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Other antiseptics and disinfectants
CHEBI has role	CHEBI:48356	protogenic solvent
MeSH PA	D012997	Solvents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Antiseptic preparation	indication	261276004
Nausea and vomiting	off-label use	16932000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

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Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
2%;70% (10.5ML)	CHLORAPREP WITH TINT	BECTON DICKINSON CO	N020832	April 3, 2006	OTC	SPONGE	TOPICAL	7422388	April 25, 2027	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (26ML)	CHLORAPREP WITH TINT	BECTON DICKINSON CO	N020832	May 3, 2005	OTC	SPONGE	TOPICAL	7422388	April 25, 2027	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
2%;70% (3ML)	CHLORAPREP WITH TINT	BECTON DICKINSON CO	N020832	Oct. 10, 2006	OTC	SPONGE	TOPICAL	7422388	April 25, 2027	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70%	ZURAGARD	ZUREX PHARMA	N210872	April 26, 2019	OTC	SOLUTION	TOPICAL	9629368	May 23, 2028	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70%	ZURAGARD	ZUREX PHARMA	N210872	April 26, 2019	OTC	SOLUTION	TOPICAL	8389583	Aug. 9, 2029	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70%	ZURAGARD	ZUREX PHARMA	N210872	April 26, 2019	OTC	SOLUTION	TOPICAL	10688291	Dec. 20, 2034	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY
70%	ZURAGARD	ZUREX PHARMA	N210872	April 26, 2019	OTC	SOLUTION	TOPICAL	9844654	April 24, 2036	USE AS AN ANTISEPTIC FOR THE PREPARATION OF A PATIENTS SKIN PRIOR TO SURGERY

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Orange Book exclusivity data (new drug applications)

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Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
2%;70%	SOLUPREP S	3M HEALTH CARE	N208288	Aug. 8, 2018	OTC	SOLUTION	TOPICAL	Jan. 20, 2026	REVISIONS TO THE LABELING TO DESCRIBE MODIFIED FORMULATION BASED ON RESULTS OF STUDIES EM-05-014624 AND EM-05-014815
70%	ZURAGARD	ZUREX PHARMA	N210872	April 26, 2019	OTC	SOLUTION	TOPICAL	June 24, 2024	ADDITION OF INFORMATION TO THE LABEL REGARDING A CLEAR PRODUCT PRESENTATION AND 26 ML VOLUME PRODUCTS

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Bioactivity Summary:

None

External reference:

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ID	Source
IPA	PDB_CHEM_ID
002465	NDDF
11314	MMSL
259268001	SNOMEDCT_US
3776	PUBCHEM_CID
4017589	VANDF
4018437	VUID
4018437	VANDF
414547000	SNOMEDCT_US
4930	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
70%	HUMAN OTC DRUG LABEL	1	0363-0810	LIQUID	70 mL	TOPICAL	OTC monograph not final	15 sections
70%	HUMAN OTC DRUG LABEL	1	0363-0810	LIQUID	500 mg	TOPICAL	OTC monograph not final	15 sections
70%	HUMAN OTC DRUG LABEL	1	0363-0810	LIQUID	500 mg	TOPICAL	OTC monograph not final	15 sections
70% Rubbing	HUMAN OTC DRUG LABEL	1	0363-0845	LIQUID	500 mg	TOPICAL	OTC monograph not final	12 sections
70% Rubbing	HUMAN OTC DRUG LABEL	1	0363-0845	LIQUID	500 mg	TOPICAL	OTC monograph not final	12 sections
Ear Drops for Swimmers	HUMAN OTC DRUG LABEL	1	0395-9103	LIQUID	950 mg	AURICULAR (OTIC)	OTC monograph final	15 sections
EAR DRY DROPSWELL AT WALGREENS	HUMAN OTC DRUG LABEL	1	0363-3019	LIQUID	95.00 1	AURICULAR (OTIC)	OTC monograph final	11 sections
Hibistat	HUMAN OTC DRUG LABEL	2	0234-0587	SOLUTION	70 g	TOPICAL	NDA	13 sections
HUMCO 1 Percent Iodine	HUMAN OTC DRUG LABEL	1	0395-1211	LIQUID	700 mg	TOPICAL	OTC monograph not final	11 sections
HUMCO Ear Drops for Swimmers	HUMAN OTC DRUG LABEL	1	0395-0098	LIQUID	950 mg	AURICULAR (OTIC)	OTC monograph final	14 sections

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