Stem definition | Drug id | CAS RN |
---|---|---|
angiotensin-converting enzyme inhibitors | 484 | 62571-86-2 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 160 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 38 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.72 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 69 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.75 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 12 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.73 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
April 6, 1981 | FDA | PAR PHARM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Segmental diverticular colitis | 96.41 | 14.85 | 18 | 11414 | 156 | 63477434 |
Pedal pulse abnormal | 95.60 | 14.85 | 18 | 11414 | 164 | 63477426 |
Toxic epidermal necrolysis | 86.60 | 14.85 | 55 | 11377 | 25279 | 63452311 |
Calcium ionised decreased | 86.10 | 14.85 | 18 | 11414 | 291 | 63477299 |
Blood pressure abnormal | 75.50 | 14.85 | 42 | 11390 | 15156 | 63462434 |
Cardiac failure congestive | 75.41 | 14.85 | 88 | 11344 | 92345 | 63385245 |
Insulin autoimmune syndrome | 70.89 | 14.85 | 13 | 11419 | 101 | 63477489 |
Feeding intolerance | 69.65 | 14.85 | 18 | 11414 | 756 | 63476834 |
Reduced facial expression | 65.12 | 14.85 | 21 | 11411 | 1945 | 63475645 |
Multiple organ dysfunction syndrome | 60.12 | 14.85 | 62 | 11370 | 56690 | 63420900 |
Restlessness | 56.60 | 14.85 | 45 | 11387 | 29408 | 63448182 |
Listless | 53.72 | 14.85 | 20 | 11412 | 2840 | 63474750 |
Dermatitis exfoliative | 53.69 | 14.85 | 24 | 11408 | 5435 | 63472155 |
Head discomfort | 50.57 | 14.85 | 31 | 11401 | 13384 | 63464206 |
Self-injurious ideation | 47.78 | 14.85 | 18 | 11414 | 2641 | 63474949 |
Labile hypertension | 42.27 | 14.85 | 11 | 11421 | 475 | 63477115 |
Left ventricular hypertrophy | 41.77 | 14.85 | 20 | 11412 | 5295 | 63472295 |
Myocardial infarction | 40.53 | 14.85 | 68 | 11364 | 99825 | 63377765 |
Gastrointestinal sounds abnormal | 40.45 | 14.85 | 18 | 11414 | 4033 | 63473557 |
Hyponatraemia | 39.96 | 14.85 | 72 | 11360 | 111828 | 63365762 |
Prescription drug used without a prescription | 38.73 | 14.85 | 15 | 11417 | 2371 | 63475219 |
Cardiac failure | 37.93 | 14.85 | 62 | 11370 | 89080 | 63388510 |
Apathy | 37.49 | 14.85 | 22 | 11410 | 8772 | 63468818 |
Electrolyte imbalance | 37.13 | 14.85 | 30 | 11402 | 20046 | 63457544 |
Hyperthyroidism | 36.12 | 14.85 | 26 | 11406 | 14647 | 63462943 |
Foreign body | 35.49 | 14.85 | 14 | 11418 | 2324 | 63475266 |
Dehydration | 34.56 | 14.85 | 88 | 11344 | 173266 | 63304324 |
Haemodynamic instability | 34.03 | 14.85 | 21 | 11411 | 9169 | 63468421 |
Immobile | 33.89 | 14.85 | 18 | 11414 | 5925 | 63471665 |
Drug interaction | 33.58 | 14.85 | 104 | 11328 | 229027 | 63248563 |
Cholecystitis | 32.80 | 14.85 | 25 | 11407 | 15352 | 63462238 |
Joint swelling | 31.36 | 14.85 | 10 | 11422 | 327656 | 63149934 |
Affect lability | 30.32 | 14.85 | 21 | 11411 | 11130 | 63466460 |
Hypokalaemia | 29.92 | 14.85 | 61 | 11371 | 103743 | 63373847 |
Fatigue | 29.21 | 14.85 | 74 | 11358 | 887954 | 62589636 |
Skin test positive | 29.15 | 14.85 | 9 | 11423 | 723 | 63476867 |
Renal failure | 29.14 | 14.85 | 65 | 11367 | 117587 | 63360003 |
Arthralgia | 29.08 | 14.85 | 36 | 11396 | 569674 | 62907916 |
Abdominal discomfort | 28.63 | 14.85 | 11 | 11421 | 320874 | 63156716 |
Atrial fibrillation | 28.40 | 14.85 | 64 | 11368 | 116572 | 63361018 |
Systemic lupus erythematosus | 27.08 | 14.85 | 3 | 11429 | 208915 | 63268675 |
Acute myocardial infarction | 26.86 | 14.85 | 31 | 11401 | 32093 | 63445497 |
Cognitive disorder | 26.74 | 14.85 | 41 | 11391 | 55774 | 63421816 |
Hypertensive crisis | 26.50 | 14.85 | 22 | 11410 | 15264 | 63462326 |
Blood urea increased | 26.45 | 14.85 | 28 | 11404 | 26351 | 63451239 |
Hypotension | 26.40 | 14.85 | 108 | 11324 | 272496 | 63205094 |
Infusion related reaction | 26.29 | 14.85 | 6 | 11426 | 245515 | 63232075 |
Metabolic acidosis | 25.78 | 14.85 | 36 | 11396 | 45033 | 63432557 |
Respiratory disorder | 25.06 | 14.85 | 33 | 11399 | 39049 | 63438541 |
Cholelithiasis | 25.00 | 14.85 | 35 | 11397 | 43890 | 63433700 |
Alopecia | 24.88 | 14.85 | 15 | 11417 | 337521 | 63140069 |
Pain | 24.88 | 14.85 | 61 | 11371 | 740567 | 62737023 |
Therapeutic product effect decreased | 24.48 | 14.85 | 3 | 11429 | 193184 | 63284406 |
Acute kidney injury | 23.66 | 14.85 | 102 | 11330 | 263313 | 63214277 |
Circulatory collapse | 23.27 | 14.85 | 24 | 11408 | 21914 | 63455676 |
Occupational exposure to product | 23.24 | 14.85 | 10 | 11422 | 2068 | 63475522 |
Cross sensitivity reaction | 22.85 | 14.85 | 10 | 11422 | 2152 | 63475438 |
Vascular stent thrombosis | 22.72 | 14.85 | 8 | 11424 | 969 | 63476621 |
Abnormal behaviour | 21.94 | 14.85 | 23 | 11409 | 21403 | 63456187 |
Urinary retention | 21.65 | 14.85 | 27 | 11405 | 30274 | 63447316 |
Renal injury | 21.58 | 14.85 | 16 | 11416 | 9423 | 63468167 |
Bedridden | 21.47 | 14.85 | 17 | 11415 | 11034 | 63466556 |
Hyperkalaemia | 20.78 | 14.85 | 36 | 11396 | 54167 | 63423423 |
Off label use | 20.76 | 14.85 | 58 | 11374 | 674404 | 62803186 |
Cyanosis | 20.68 | 14.85 | 20 | 11412 | 16915 | 63460675 |
Rheumatoid arthritis | 20.56 | 14.85 | 10 | 11422 | 253809 | 63223781 |
Contraindicated product administered | 20.18 | 14.85 | 7 | 11425 | 217641 | 63259949 |
Sudden death | 20.14 | 14.85 | 16 | 11416 | 10433 | 63467157 |
Blood sodium decreased | 19.60 | 14.85 | 23 | 11409 | 24229 | 63453361 |
Progressive supranuclear palsy | 19.29 | 14.85 | 4 | 11428 | 62 | 63477528 |
Cardiac failure acute | 19.25 | 14.85 | 15 | 11417 | 9508 | 63468082 |
Blood creatinine increased | 18.96 | 14.85 | 46 | 11386 | 87798 | 63389792 |
Maternal exposure during pregnancy | 18.87 | 14.85 | 8 | 11424 | 220054 | 63257536 |
Musculoskeletal stiffness | 18.81 | 14.85 | 5 | 11427 | 184613 | 63292977 |
Bradycardia | 18.73 | 14.85 | 41 | 11391 | 73186 | 63404404 |
Coronary artery disease | 18.72 | 14.85 | 26 | 11406 | 32351 | 63445239 |
Pelvic fracture | 18.67 | 14.85 | 17 | 11415 | 13331 | 63464259 |
Elastosis perforans | 18.47 | 14.85 | 3 | 11429 | 10 | 63477580 |
Posterior reversible encephalopathy syndrome | 18.44 | 14.85 | 19 | 11413 | 17326 | 63460264 |
Nodal rhythm | 18.22 | 14.85 | 8 | 11424 | 1735 | 63475855 |
Artery dissection | 18.14 | 14.85 | 4 | 11428 | 84 | 63477506 |
Encephalopathy | 17.97 | 14.85 | 28 | 11404 | 38592 | 63438998 |
Arthropathy | 17.91 | 14.85 | 10 | 11422 | 234782 | 63242808 |
Cerebrovascular accident | 17.66 | 14.85 | 51 | 11381 | 107973 | 63369617 |
Blood potassium decreased | 17.55 | 14.85 | 29 | 11403 | 41997 | 63435593 |
Lymphocytosis | 17.55 | 14.85 | 9 | 11423 | 2758 | 63474832 |
Stevens-Johnson syndrome | 17.46 | 14.85 | 22 | 11410 | 24928 | 63452662 |
Extrasystoles | 17.12 | 14.85 | 11 | 11421 | 5149 | 63472441 |
Scleroderma renal crisis | 17.08 | 14.85 | 5 | 11427 | 335 | 63477255 |
Shock | 16.91 | 14.85 | 21 | 11411 | 23442 | 63454148 |
Sinusitis | 16.79 | 14.85 | 10 | 11422 | 226643 | 63250947 |
Renal impairment | 16.70 | 14.85 | 44 | 11388 | 88311 | 63389279 |
Potentiating drug interaction | 16.24 | 14.85 | 10 | 11422 | 4346 | 63473244 |
Angiopathy | 15.72 | 14.85 | 10 | 11422 | 4603 | 63472987 |
Nasopharyngitis | 15.24 | 14.85 | 14 | 11418 | 254243 | 63223347 |
Occupational dermatitis | 14.89 | 14.85 | 3 | 11429 | 40 | 63477550 |
Hepatic enzyme increased | 14.88 | 14.85 | 9 | 11423 | 202319 | 63275271 |
Hypoacusis | 14.88 | 14.85 | 20 | 11412 | 24131 | 63453459 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood ketone body increased | 35.55 | 14.69 | 10 | 8385 | 433 | 34948103 |
Cyanosis | 32.68 | 14.69 | 26 | 8369 | 12738 | 34935798 |
Angioedema | 28.81 | 14.69 | 40 | 8355 | 37334 | 34911202 |
Hypertensive crisis | 27.18 | 14.69 | 20 | 8375 | 8731 | 34939805 |
Cardiac failure congestive | 27.13 | 14.69 | 61 | 8334 | 83209 | 34865327 |
Scleroderma renal crisis | 26.08 | 14.69 | 7 | 8388 | 254 | 34948282 |
Renal failure | 24.57 | 14.69 | 78 | 8317 | 130479 | 34818057 |
Kidney small | 23.86 | 14.69 | 5 | 8390 | 60 | 34948476 |
Myocardial infarction | 23.39 | 14.69 | 73 | 8322 | 121012 | 34827524 |
Cerebrovascular accident | 23.15 | 14.69 | 58 | 8337 | 84753 | 34863783 |
Coronary artery disease | 22.42 | 14.69 | 41 | 8354 | 48264 | 34900272 |
Blood creatinine increased | 20.92 | 14.69 | 60 | 8335 | 94916 | 34853620 |
Long QT syndrome | 20.41 | 14.69 | 11 | 8384 | 2792 | 34945744 |
Indifference | 19.51 | 14.69 | 5 | 8390 | 151 | 34948385 |
Hypokalaemia | 19.34 | 14.69 | 43 | 8352 | 58171 | 34890365 |
Pulmonary hypertensive crisis | 19.00 | 14.69 | 5 | 8390 | 168 | 34948368 |
Pulmonary hypoplasia | 17.63 | 14.69 | 6 | 8389 | 491 | 34948045 |
Reaction to excipient | 17.42 | 14.69 | 6 | 8389 | 509 | 34948027 |
Vitamin B12 deficiency | 16.71 | 14.69 | 11 | 8384 | 4020 | 34944516 |
Vascular resistance systemic decreased | 16.33 | 14.69 | 4 | 8391 | 100 | 34948436 |
Arrhythmia | 16.11 | 14.69 | 30 | 8365 | 35778 | 34912758 |
Renal failure neonatal | 15.83 | 14.69 | 4 | 8391 | 114 | 34948422 |
Bronchospasm | 15.80 | 14.69 | 16 | 8379 | 10715 | 34937821 |
Drug reaction with eosinophilia and systemic symptoms | 15.28 | 14.69 | 28 | 8367 | 32984 | 34915552 |
Cardiac failure | 14.90 | 14.69 | 52 | 8343 | 91196 | 34857340 |
Renal impairment | 14.70 | 14.69 | 53 | 8342 | 94460 | 34854076 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Segmental diverticular colitis | 92.96 | 12.81 | 18 | 17372 | 156 | 79726842 |
Pedal pulse abnormal | 91.01 | 12.81 | 18 | 17372 | 176 | 79726822 |
Cardiac failure congestive | 88.91 | 12.81 | 131 | 17259 | 142271 | 79584727 |
Calcium ionised decreased | 71.17 | 12.81 | 18 | 17372 | 569 | 79726429 |
Feeding intolerance | 64.35 | 12.81 | 18 | 17372 | 842 | 79726156 |
Myocardial infarction | 60.77 | 12.81 | 128 | 17262 | 184001 | 79542997 |
Toxic epidermal necrolysis | 58.99 | 12.81 | 60 | 17330 | 44521 | 79682477 |
Insulin autoimmune syndrome | 51.15 | 12.81 | 13 | 17377 | 419 | 79726579 |
Reduced facial expression | 50.65 | 12.81 | 20 | 17370 | 2745 | 79724253 |
Cyanosis | 46.95 | 12.81 | 41 | 17349 | 25141 | 79701857 |
Renal failure | 45.88 | 12.81 | 121 | 17269 | 200847 | 79526151 |
Hypertensive crisis | 45.27 | 12.81 | 37 | 17353 | 20733 | 79706265 |
Blood pressure abnormal | 42.59 | 12.81 | 33 | 17357 | 17136 | 79709862 |
Cardiac failure | 42.46 | 12.81 | 100 | 17290 | 154742 | 79572256 |
Self-injurious ideation | 42.15 | 12.81 | 19 | 17371 | 3619 | 79723379 |
Head discomfort | 40.68 | 12.81 | 30 | 17360 | 14472 | 79712526 |
Multiple organ dysfunction syndrome | 40.11 | 12.81 | 84 | 17306 | 120162 | 79606836 |
Labile hypertension | 38.85 | 12.81 | 11 | 17379 | 538 | 79726460 |
Cerebrovascular accident | 38.01 | 12.81 | 96 | 17294 | 155196 | 79571802 |
Listless | 37.97 | 12.81 | 18 | 17372 | 3843 | 79723155 |
Gastrointestinal sounds abnormal | 37.71 | 12.81 | 20 | 17370 | 5415 | 79721583 |
Apathy | 36.75 | 12.81 | 27 | 17363 | 12950 | 79714048 |
Dermatitis exfoliative | 36.37 | 12.81 | 25 | 17365 | 10804 | 79716194 |
Coronary artery disease | 36.24 | 12.81 | 57 | 17333 | 65417 | 79661581 |
Restlessness | 35.27 | 12.81 | 47 | 17343 | 46445 | 79680553 |
Joint swelling | 34.63 | 12.81 | 10 | 17380 | 288636 | 79438362 |
Blood creatinine increased | 34.00 | 12.81 | 92 | 17298 | 154965 | 79572033 |
Angioedema | 33.80 | 12.81 | 60 | 17330 | 75975 | 79651023 |
Scleroderma renal crisis | 33.48 | 12.81 | 10 | 17380 | 591 | 79726407 |
Electrolyte imbalance | 32.80 | 12.81 | 37 | 17353 | 30844 | 79696154 |
Off label use | 32.72 | 12.81 | 96 | 17294 | 907119 | 78819879 |
Drug interaction | 32.41 | 12.81 | 177 | 17213 | 415006 | 79311992 |
Completed suicide | 32.41 | 12.81 | 7 | 17383 | 245760 | 79481238 |
Occupational exposure to product | 31.98 | 12.81 | 10 | 17380 | 690 | 79726308 |
Hypotension | 31.91 | 12.81 | 184 | 17206 | 440133 | 79286865 |
Hyponatraemia | 30.80 | 12.81 | 97 | 17293 | 177751 | 79549247 |
Hypokalaemia | 29.14 | 12.81 | 83 | 17307 | 143957 | 79583041 |
Prescription drug used without a prescription | 28.25 | 12.81 | 15 | 17375 | 4070 | 79722928 |
Blood ketone body increased | 27.57 | 12.81 | 9 | 17381 | 713 | 79726285 |
Acute myocardial infarction | 27.07 | 12.81 | 55 | 17335 | 76981 | 79650017 |
Foreign body | 26.96 | 12.81 | 13 | 17377 | 2881 | 79724117 |
Immobile | 25.57 | 12.81 | 17 | 17373 | 6956 | 79720042 |
Renal impairment | 25.45 | 12.81 | 84 | 17306 | 157699 | 79569299 |
Pulmonary hypoplasia | 24.83 | 12.81 | 5 | 17385 | 54 | 79726944 |
Arthralgia | 24.82 | 12.81 | 55 | 17335 | 571748 | 79155250 |
Bradycardia | 24.45 | 12.81 | 75 | 17315 | 135482 | 79591516 |
Hyperthyroidism | 24.25 | 12.81 | 27 | 17363 | 22182 | 79704816 |
Cholecystitis | 24.25 | 12.81 | 27 | 17363 | 22185 | 79704813 |
Cross sensitivity reaction | 23.91 | 12.81 | 13 | 17377 | 3699 | 79723299 |
Posterior reversible encephalopathy syndrome | 23.77 | 12.81 | 29 | 17361 | 26252 | 79700746 |
Rheumatoid arthritis | 23.60 | 12.81 | 8 | 17382 | 208462 | 79518536 |
Skin test positive | 23.30 | 12.81 | 9 | 17381 | 1165 | 79725833 |
Abdominal discomfort | 23.05 | 12.81 | 13 | 17377 | 250714 | 79476284 |
Fatigue | 22.76 | 12.81 | 115 | 17275 | 929612 | 78797386 |
Cholelithiasis | 22.69 | 12.81 | 41 | 17349 | 52623 | 79674375 |
Left ventricular hypertrophy | 22.44 | 12.81 | 19 | 17371 | 11172 | 79715826 |
Affect lability | 22.34 | 12.81 | 19 | 17371 | 11240 | 79715758 |
Respiratory disorder | 22.03 | 12.81 | 37 | 17353 | 44819 | 79682179 |
Drug reaction with eosinophilia and systemic symptoms | 21.55 | 12.81 | 45 | 17345 | 64199 | 79662799 |
Dehydration | 21.52 | 12.81 | 109 | 17281 | 248078 | 79478920 |
Indifference | 21.12 | 12.81 | 6 | 17384 | 297 | 79726701 |
Infusion related reaction | 21.08 | 12.81 | 12 | 17378 | 230225 | 79496773 |
Renal injury | 20.97 | 12.81 | 22 | 17368 | 16905 | 79710093 |
Nasopharyngitis | 20.82 | 12.81 | 15 | 17375 | 253866 | 79473132 |
Pulmonary oedema | 19.97 | 12.81 | 53 | 17337 | 88201 | 79638797 |
Atrial fibrillation | 19.37 | 12.81 | 90 | 17300 | 197796 | 79529202 |
Bedridden | 19.23 | 12.81 | 18 | 17372 | 12061 | 79714937 |
Cognitive disorder | 18.97 | 12.81 | 45 | 17345 | 69881 | 79657117 |
Alopecia | 18.54 | 12.81 | 14 | 17376 | 231341 | 79495657 |
Blood urea increased | 18.54 | 12.81 | 36 | 17354 | 48754 | 79678244 |
COVID-19 treatment | 18.52 | 12.81 | 6 | 17384 | 464 | 79726534 |
Lower respiratory tract infection | 18.48 | 12.81 | 3 | 17387 | 129217 | 79597781 |
Long QT syndrome | 18.25 | 12.81 | 13 | 17377 | 5942 | 79721056 |
Ventricular extrasystoles | 18.24 | 12.81 | 22 | 17368 | 19682 | 79707316 |
Elastosis perforans | 17.67 | 12.81 | 3 | 17387 | 11 | 79726987 |
Arrhythmia | 17.24 | 12.81 | 40 | 17350 | 61232 | 79665766 |
Kidney small | 17.23 | 12.81 | 5 | 17385 | 267 | 79726731 |
Pelvic fracture | 17.19 | 12.81 | 17 | 17373 | 12187 | 79714811 |
Haemodynamic instability | 17.06 | 12.81 | 20 | 17370 | 17362 | 79709636 |
Hypertension | 17.03 | 12.81 | 127 | 17263 | 330865 | 79396133 |
Blood potassium increased | 16.91 | 12.81 | 26 | 17364 | 29249 | 79697749 |
Oligohydramnios | 16.73 | 12.81 | 10 | 17380 | 3402 | 79723596 |
Laryngeal oedema | 16.71 | 12.81 | 14 | 17376 | 8115 | 79718883 |
Tongue oedema | 16.19 | 12.81 | 13 | 17377 | 7104 | 79719894 |
Pain | 16.10 | 12.81 | 89 | 17301 | 703713 | 79023285 |
Blood potassium decreased | 16.09 | 12.81 | 33 | 17357 | 46479 | 79680519 |
Hyperplasia | 16.03 | 12.81 | 7 | 17383 | 1236 | 79725762 |
Stomatitis | 15.98 | 12.81 | 6 | 17384 | 146751 | 79580247 |
Wound | 15.95 | 12.81 | 3 | 17387 | 116176 | 79610822 |
Hyperkalaemia | 15.91 | 12.81 | 58 | 17332 | 114340 | 79612658 |
Progressive supranuclear palsy | 15.89 | 12.81 | 4 | 17386 | 124 | 79726874 |
Pulmonary hypertensive crisis | 15.85 | 12.81 | 5 | 17385 | 355 | 79726643 |
Circulatory collapse | 15.81 | 12.81 | 29 | 17361 | 37639 | 79689359 |
Therapeutic product effect decreased | 15.78 | 12.81 | 8 | 17382 | 163855 | 79563143 |
Extrasystoles | 15.71 | 12.81 | 13 | 17377 | 7406 | 79719592 |
Cardiac failure acute | 15.69 | 12.81 | 20 | 17370 | 18909 | 79708089 |
Drug ineffective | 15.51 | 12.81 | 156 | 17234 | 1080757 | 78646241 |
Congenital anomaly | 15.51 | 12.81 | 5 | 17385 | 381 | 79726617 |
Klebsiella infection | 15.29 | 12.81 | 18 | 17372 | 15702 | 79711296 |
Shock | 15.19 | 12.81 | 31 | 17359 | 43517 | 79683481 |
Haemorrhagic necrotic pancreatitis | 15.03 | 12.81 | 4 | 17386 | 155 | 79726843 |
Nodal rhythm | 14.88 | 12.81 | 9 | 17381 | 3126 | 79723872 |
Musculoskeletal stiffness | 14.79 | 12.81 | 10 | 17380 | 174998 | 79552000 |
Lactic acidosis | 14.66 | 12.81 | 41 | 17349 | 70318 | 79656680 |
Scleroedema | 14.46 | 12.81 | 3 | 17387 | 38 | 79726960 |
Sinusitis | 14.22 | 12.81 | 13 | 17377 | 195488 | 79531510 |
Pulmonary hypertension | 14.20 | 12.81 | 32 | 17358 | 48048 | 79678950 |
Maternal exposure during pregnancy | 14.18 | 12.81 | 6 | 17384 | 136532 | 79590466 |
Angiopathy | 14.15 | 12.81 | 12 | 17378 | 7070 | 79719928 |
Vascular resistance systemic decreased | 13.65 | 12.81 | 4 | 17386 | 221 | 79726777 |
Cardio-respiratory arrest | 13.43 | 12.81 | 53 | 17337 | 108457 | 79618541 |
Rhabdomyolysis | 13.27 | 12.81 | 51 | 17339 | 103080 | 79623918 |
Rhythm idioventricular | 13.16 | 12.81 | 5 | 17385 | 619 | 79726379 |
Apraxia | 13.02 | 12.81 | 8 | 17382 | 2859 | 79724139 |
Injection site pain | 13.02 | 12.81 | 6 | 17384 | 129832 | 79597166 |
Acute interstitial pneumonitis | 12.95 | 12.81 | 6 | 17384 | 1217 | 79725781 |
Artery dissection | 12.82 | 12.81 | 4 | 17386 | 274 | 79726724 |
None
Source | Code | Description |
---|---|---|
ATC | C09AA01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
ATC | C09BA01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and diuretics |
FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
CHEBI has role | CHEBI:35457 | ACE inhibitor |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D011480 | Protease Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Chronic heart failure | indication | 48447003 | |
Diabetic renal disease | indication | 127013003 | |
Left ventricular cardiac dysfunction | indication | 429589006 | |
Atrial fibrillation | off-label use | 49436004 | DOID:0060224 |
Cystinuria | off-label use | 85020001 | DOID:9266 |
Diastolic heart failure | off-label use | 418304008 | DOID:9775 |
Cystine Renal Calculi | off-label use | ||
Nondiabetic Proteinuric Nephropathy | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Hypercholesterolemia | contraindication | 13644009 | |
Hyperkalemia | contraindication | 14140009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Immunosuppression | contraindication | 38013005 | |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Cough | contraindication | 49727002 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Transplantation | contraindication | 77465005 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Hypertrophic cardiomyopathy | contraindication | 233873004 | DOID:11984 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Azotemia | contraindication | 445009001 | |
Hemodialysis with High-Flux Membrane | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.85 | acidic |
pKa2 | 9.56 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme | Enzyme | INHIBITOR | Ki | 8.70 | WOMBAT-PK | CHEMBL | |||
Prostaglandin G/H synthase 1 | Enzyme | Ki | 4.77 | CHEMBL | |||||
Prothrombin | Enzyme | Ki | 7.32 | CHEMBL | |||||
Renin | Enzyme | Ki | 8.77 | CHEMBL | |||||
Leukotriene A-4 hydrolase | Enzyme | IC50 | 7.15 | CHEMBL | |||||
Prostaglandin G/H synthase 2 | Enzyme | Ki | 4.92 | CHEMBL | |||||
Angiotensin-converting enzyme | Enzyme | Ki | 8.77 | CHEMBL | |||||
Angiotensin-converting enzyme | Enzyme | Ki | 8.70 | CHEMBL | |||||
Succinyl-diaminopimelate desuccinylase | Enzyme | Ki | 5.74 | CHEMBL | |||||
Beta-lactamase | Enzyme | Ki | 5.62 | CHEMBL | |||||
Beta-lactamase II | Enzyme | Ki | 4.75 | CHEMBL | |||||
Beta-lactamase class B VIM-2 | Unclassified | Kd | 6.22 | CHEMBL | |||||
Beta-lactamase NDM-1 | Enzyme | Kd | 4.85 | CHEMBL |
ID | Source |
---|---|
4017614 | VUID |
N0000145994 | NUI |
D00251 | KEGG_DRUG |
1998 | RXNORM |
C0006938 | UMLSCUI |
CHEBI:3380 | CHEBI |
X8Z | PDB_CHEM_ID |
CHEMBL1560 | ChEMBL_ID |
DB01197 | DRUGBANK_ID |
D002216 | MESH_DESCRIPTOR_UI |
44093 | PUBCHEM_CID |
5158 | IUPHAR_LIGAND_ID |
4373 | INN_ID |
9G64RSX1XD | UNII |
4347 | MMSL |
455 | MMSL |
d00006 | MMSL |
29439004 | SNOMEDCT_US |
387160004 | SNOMEDCT_US |
4017614 | VANDF |
000656 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1171 | TABLET | 12.50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1171 | TABLET | 12.50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1172 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1172 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1173 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1173 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1174 | TABLET | 100 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-1174 | TABLET | 100 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4519 | TABLET | 12.50 mg | ORAL | ANDA | 21 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4520 | TABLET | 25 mg | ORAL | ANDA | 21 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-4521 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8052 | TABLET | 12.50 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8061 | TABLET | 25 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8075 | TABLET | 50 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-8080 | TABLET | 100 mg | ORAL | ANDA | 16 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5045 | TABLET | 12.50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5046 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-5047 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7105 | TABLET | 12.50 mg | ORAL | ANDA | 12 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7106 | TABLET | 25 mg | ORAL | ANDA | 12 sections |
CAPTOPRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-175 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
CAPTOPRIL AND HYDROCHLOROTHIAZIDE | Human Prescription Drug Label | 2 | 16571-827 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
CAPTOPRIL AND HYDROCHLOROTHIAZIDE | Human Prescription Drug Label | 2 | 16571-828 | TABLET | 25 mg | ORAL | ANDA | 22 sections |
CAPTOPRIL AND HYDROCHLOROTHIAZIDE | Human Prescription Drug Label | 2 | 16571-829 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
CAPTOPRIL AND HYDROCHLOROTHIAZIDE | Human Prescription Drug Label | 2 | 16571-830 | TABLET | 50 mg | ORAL | ANDA | 22 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-477 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Captopril | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-478 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-160 | TABLET | 12.50 mg | ORAL | ANDA | 12 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-161 | TABLET | 25 mg | ORAL | ANDA | 12 sections |
Captopril | Human Prescription Drug Label | 1 | 27241-162 | TABLET | 50 mg | ORAL | ANDA | 12 sections |