euflavine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
acridine derivatives	4317	69235-50-3

Description:

Molecule	Description
Synonyms: acriflavinium chloride acriflavine chloride acriflavine euflavine	3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. Molecular weight: 468.99 Formula: C27H25ClN6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 55.92 ALOGS: ROTB: None

Molecule

Description

Synonyms:

acriflavinium chloride
acriflavine chloride
acriflavine
euflavine

3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication.

Molecular weight: 468.99
Formula: C27H25ClN6
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 55.92
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D08AA03	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Acridine derivatives
ATC	R02AA13	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D004396	Coloring Agents
MeSH PA	D005456	Fluorescent Dyes
MeSH PA	D007202	Indicators and Reagents
MeSH PA	D007364	Intercalating Agents
MeSH PA	D049408	Luminescent Agents
CHEBI has role	CHEBI:24853	intercalating agents
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:50903	carcinogen
CHEBI has role	CHEBI:77178	biological stain

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Hypoxia-inducible factor 1-alpha	Transcription factor	Q16665	HIF1A_HUMAN		IC50	6		CHEMBL
ORF 73	Unclassified		O40947_HHV8		AC50	6.38		CHEMBL

External reference:

ID	Source
4020812	VUID
N0000148332	NUI
65589-70-0	SECONDARY_CAS_RN
4020580	VANDF
4020812	VANDF
CHEBI:74729	CHEBI
CHEMBL354349	ChEMBL_ID
CHEMBL1184529	ChEMBL_ID
CHEMBL2010412	ChEMBL_ID
CHEMBL5219994	ChEMBL_ID
C000718540	MESH_SUPPLEMENTAL_RECORD_UI
DB13326	DRUGBANK_ID
DB13373	DRUGBANK_ID
1664337	RXNORM
NOCODE	MMSL
002613	NDDF
412535007	SNOMEDCT_US
412537004	SNOMEDCT_US
C0001187	UMLSCUI
D000167	MESH_DESCRIPTOR_UI
443101	PUBCHEM_CID
1T3A50395T	UNII

Pharmaceutical products:

None