vancomycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2807 1404-90-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vancomycin
  • diatracin
  • vancocin
  • vancocine
  • vancoled
  • vancomycin hydrochloride
  • vancomycin HCl
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
  • Molecular weight: 1449.27
  • Formula: C66H75Cl2N9O24
  • CLOGP: -2.23
  • LIPINSKI: 3
  • HAC: 33
  • HDO: 19
  • TPSA: 530.49
  • ALOGS: -3.81
  • ROTB: 13

Drug dosage:

DoseUnitRoute
2 g O
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 79 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 22.44 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.54 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 2617.70 11.74 1137 91550 41621 90494139
Acute kidney injury 2159.11 11.74 2107 90580 318280 90217480
Linear IgA disease 973.74 11.74 261 92426 2013 90533747
Multiple organ dysfunction syndrome 932.20 11.74 677 92010 67659 90468101
Eosinophilia 727.37 11.74 419 92268 28114 90507646
Septic shock 687.87 11.74 618 92069 83542 90452218
Renal tubular necrosis 646.57 11.74 310 92377 14245 90521515
Acute generalised exanthematous pustulosis 569.92 11.74 279 92408 13424 90522336
Nephropathy toxic 553.77 11.74 267 92420 12421 90523339
Toxic epidermal necrolysis 498.09 11.74 346 92341 32182 90503578
Sepsis 468.88 11.74 735 91952 179079 90356681
Clostridium difficile infection 462.20 11.74 345 92342 35900 90499860
Pathogen resistance 407.08 11.74 188 92499 7927 90527833
Renal failure 406.41 11.74 581 92106 130426 90405334
Fatigue 385.80 11.74 369 92318 1153654 89382106
Drug ineffective 372.74 11.74 2549 90138 1381749 89154011
Arthropathy 344.49 11.74 6 92681 366236 90169524
Respiratory failure 343.73 11.74 509 92178 117909 90417851
Tubulointerstitial nephritis 340.55 11.74 249 92438 25094 90510666
Arthralgia 337.40 11.74 189 92498 778333 89757427
Rash maculo-papular 335.01 11.74 301 92386 40632 90495128
Joint swelling 326.89 11.74 60 92627 503240 90032520
Drug level increased 318.14 11.74 248 92439 27514 90508246
Antibiotic level above therapeutic 314.99 11.74 78 92609 420 90535340
Alopecia 306.89 11.74 66 92621 495005 90040755
Pyrexia 303.83 11.74 1407 91280 659078 89876682
Glossodynia 303.72 11.74 5 92682 321774 90213986
Clostridium difficile colitis 300.48 11.74 236 92451 26470 90509290
Synovitis 292.64 11.74 10 92677 329742 90206018
Retinal vasculitis 291.93 11.74 94 92593 1447 90534313
Abdominal discomfort 283.17 11.74 70 92617 477258 90058502
Drug hypersensitivity 281.07 11.74 1075 91612 462534 90073226
Contraindicated product administered 276.27 11.74 12 92675 320127 90215633
Drug resistance 273.34 11.74 236 92451 30213 90505547
Encephalopathy 271.67 11.74 284 92403 46160 90489600
Systemic lupus erythematosus 267.90 11.74 29 92658 361867 90173893
Renal impairment 254.04 11.74 416 92271 105005 90430755
Drug ineffective for unapproved indication 251.16 11.74 325 92362 66319 90469441
Pancytopenia 249.51 11.74 444 92243 119819 90415941
Headache 247.76 11.74 312 92375 862434 89673326
Staphylococcal infection 242.74 11.74 273 92414 48166 90487594
Enterococcal infection 239.38 11.74 141 92546 9850 90525910
Stevens-Johnson syndrome 236.38 11.74 214 92473 29162 90506598
Thrombocytopenia 226.10 11.74 592 92095 208133 90327627
Rheumatoid arthritis 225.27 11.74 48 92639 362566 90173194
Haemophagocytic lymphohistiocytosis 221.63 11.74 158 92529 15301 90520459
Toxic skin eruption 216.48 11.74 157 92530 15617 90520143
Pain 212.14 11.74 439 92248 995902 89539858
Disseminated intravascular coagulation 205.71 11.74 173 92514 21365 90514395
Blood creatinine increased 204.75 11.74 370 92317 101016 90434744
Febrile neutropenia 202.94 11.74 479 92208 157870 90377890
Psoriatic arthropathy 202.25 11.74 7 92680 228328 90307432
Pericarditis 201.52 11.74 21 92666 270130 90265630
Shock 201.42 11.74 194 92493 28584 90507176
Dizziness 200.13 11.74 185 92502 589099 89946661
Wound 192.52 11.74 38 92649 302942 90232818
Swelling 188.05 11.74 97 92590 418961 90116799
Renal injury 188.05 11.74 122 92565 10121 90525639
Hypotension 187.47 11.74 743 91944 324654 90211106
Peripheral swelling 183.33 11.74 97 92590 413009 90122751
Acute respiratory distress syndrome 183.30 11.74 184 92503 28502 90507258
Musculoskeletal stiffness 182.61 11.74 40 92647 296492 90239268
Therapeutic product effect decreased 180.20 11.74 33 92654 277538 90258222
Nasopharyngitis 178.59 11.74 97 92590 407007 90128753
Cholestasis 175.77 11.74 201 92486 36098 90499662
Duodenal ulcer perforation 170.85 11.74 15 92672 221273 90314487
Fibromyalgia 170.68 11.74 10 92677 206259 90329501
Irritable bowel syndrome 163.07 11.74 13 92674 207435 90328325
Bacterial disease carrier 162.74 11.74 64 92623 1802 90533958
Folliculitis 160.10 11.74 13 92674 204340 90331420
Bacteraemia 157.32 11.74 151 92536 22149 90513611
Sleep disorder 154.03 11.74 13 92674 198017 90337743
Drug intolerance 153.64 11.74 139 92548 447452 90088308
Insomnia 152.84 11.74 75 92612 333399 90202361
Cardiac arrest 152.80 11.74 334 92353 104601 90431159
Weight increased 150.47 11.74 124 92563 417803 90117957
Superinfection 149.56 11.74 70 92617 3042 90532718
Discomfort 148.11 11.74 48 92639 274287 90261473
Hypoaesthesia 148.09 11.74 68 92619 314142 90221618
Blood cholesterol increased 148.04 11.74 19 92668 207993 90327767
Dysbiosis 147.12 11.74 58 92629 1644 90534116
Mobility decreased 146.14 11.74 38 92649 250696 90285064
Drug level above therapeutic 144.49 11.74 84 92603 5725 90530035
Neutropenia 141.24 11.74 528 92159 224376 90311384
Rash morbilliform 140.98 11.74 73 92614 3956 90531804
Pain in extremity 137.40 11.74 155 92532 450374 90085386
Staphylococcal bacteraemia 137.21 11.74 89 92598 7380 90528380
Anaphylactic reaction 135.94 11.74 286 92401 87238 90448522
Stenotrophomonas infection 134.40 11.74 61 92626 2468 90533292
Leukocytosis 134.08 11.74 162 92525 30828 90504932
Agranulocytosis 133.87 11.74 172 92515 34830 90500930
Pseudomembranous colitis 132.24 11.74 69 92618 3799 90531961
Device related infection 132.02 11.74 147 92540 25639 90510121
Mucormycosis 130.17 11.74 68 92619 3753 90532007
Sinusitis 129.51 11.74 97 92590 342991 90192769
Memory impairment 128.95 11.74 23 92664 197221 90338539
Ill-defined disorder 128.92 11.74 18 92669 184873 90350887
Dry mouth 128.14 11.74 18 92669 184041 90351719
Leukopenia 126.08 11.74 302 92385 100408 90435352
Type 2 diabetes mellitus 125.93 11.74 27 92660 203217 90332543
Bronchial secretion retention 125.06 11.74 65 92622 3550 90532210
Bronchopulmonary aspergillosis 124.48 11.74 99 92588 11299 90524461
Abdominal pain upper 124.36 11.74 95 92592 332579 90203181
Systemic candida 124.11 11.74 72 92615 4887 90530873
Aplastic anaemia 123.45 11.74 105 92582 13164 90522596
Product dose omission issue 122.83 11.74 73 92614 291614 90244146
Malaise 121.96 11.74 261 92426 585725 89950035
Muscle spasms 121.03 11.74 53 92634 251830 90283930
Fungaemia 120.98 11.74 62 92625 3288 90532472
Infusion related reaction 118.96 11.74 151 92536 416629 90119131
Hypoxia 118.79 11.74 242 92445 72157 90463603
Klebsiella infection 117.97 11.74 92 92595 10205 90525555
Impaired healing 117.82 11.74 46 92641 234153 90301607
Endophthalmitis 117.20 11.74 68 92619 4617 90531143
Fall 111.98 11.74 201 92486 481609 90054151
Dermatitis exfoliative 111.72 11.74 70 92617 5466 90530294
Haemodynamic instability 111.49 11.74 94 92593 11645 90524115
Hepatic enzyme increased 108.97 11.74 125 92562 360611 90175149
Bursitis 107.04 11.74 7 92680 131647 90404113
Contusion 106.99 11.74 62 92625 251154 90284606
Candida infection 105.39 11.74 151 92536 33906 90501854
Acinetobacter infection 105.34 11.74 48 92639 1960 90533800
Drug eruption 105.21 11.74 154 92533 35253 90500507
Symmetrical drug-related intertriginous and flexural exanthema 104.84 11.74 39 92648 940 90534820
Cytokine release syndrome 104.69 11.74 136 92551 27837 90507923
Osteoarthritis 102.56 11.74 36 92651 195694 90340066
Respiratory distress 102.40 11.74 160 92527 38786 90496974
Atelectasis 101.38 11.74 125 92562 24284 90511476
Systemic inflammatory response syndrome 101.31 11.74 70 92617 6446 90529314
Bronchospasm 100.80 11.74 115 92572 20594 90515166
Neurotoxicity 100.77 11.74 117 92570 21350 90514410
Gait inability 100.36 11.74 15 92672 146441 90389319
Haemorrhagic vasculitis 99.69 11.74 23 92664 86 90535674
Lower respiratory tract infection 99.64 11.74 67 92620 250592 90285168
Off label use 98.27 11.74 1626 91061 1100626 89435134
Injection site pain 98.03 11.74 28 92659 173671 90362089
Erythema 98.00 11.74 479 92208 228767 90306993
Metabolic acidosis 97.20 11.74 191 92496 55485 90480275
Gait disturbance 96.54 11.74 75 92612 260421 90275339
Arthritis 96.24 11.74 26 92661 167289 90368471
Pseudomonas infection 96.15 11.74 96 92591 14769 90520991
Musculoskeletal pain 95.92 11.74 28 92659 171223 90364537
Rhinocerebral mucormycosis 93.05 11.74 34 92653 778 90534982
Type IV hypersensitivity reaction 92.98 11.74 55 92632 3871 90531889
Dermatitis bullous 90.63 11.74 79 92608 10237 90525523
Joint range of motion decreased 90.44 11.74 15 92672 135628 90400132
Face oedema 89.82 11.74 115 92572 23203 90512557
Haemodialysis 89.22 11.74 73 92614 8674 90527086
Psoriasis 88.76 11.74 21 92666 147733 90388027
Aspergillus infection 87.35 11.74 79 92608 10744 90525016
Sciatica 86.72 11.74 4 92683 101378 90434382
Hypercholesterolaemia 86.24 11.74 4 92683 100888 90434872
Pleural effusion 85.88 11.74 281 92406 111710 90424050
C-reactive protein abnormal 85.16 11.74 14 92673 127415 90408345
Gastrooesophageal reflux disease 84.76 11.74 32 92655 166305 90369455
Oliguria 82.72 11.74 76 92611 10548 90525212
Hypertension 82.23 11.74 220 92467 457312 90078448
Crystal nephropathy 81.53 11.74 34 92653 1117 90534643
Noninfectious peritonitis 81.51 11.74 21 92666 136 90535624
Grip strength decreased 81.37 11.74 3 92684 92573 90443187
Transaminases increased 80.53 11.74 140 92547 37052 90498708
Night sweats 79.96 11.74 17 92670 128749 90407011
Migraine 79.62 11.74 48 92639 190344 90345416
Acute respiratory failure 79.52 11.74 151 92536 42767 90492993
Obesity 79.14 11.74 8 92679 105499 90430261
Tachycardia 78.83 11.74 345 92342 157328 90378432
Endocarditis 78.14 11.74 62 92625 7051 90528709
Depression 77.60 11.74 117 92570 300484 90235276
Dyspepsia 77.36 11.74 54 92633 198106 90337654
Graft versus host disease 76.90 11.74 65 92622 8079 90527681
Mental status changes 76.45 11.74 152 92535 44527 90491233
Drug interaction 76.25 11.74 514 92173 275939 90259821
Ototoxicity 75.74 11.74 38 92649 1926 90533834
Nausea 75.68 11.74 749 91938 1109567 89426193
Constipation 75.45 11.74 106 92581 280289 90255471
Stomatitis 74.76 11.74 103 92584 274595 90261165
Hyperbilirubinaemia 74.02 11.74 81 92606 13855 90521905
Lower limb fracture 73.88 11.74 3 92684 85010 90450750
Rash erythematous 73.81 11.74 188 92499 64916 90470844
Escherichia infection 73.55 11.74 86 92601 15809 90519951
Paraesthesia 73.13 11.74 89 92598 250237 90285523
Hypoalbuminaemia 71.88 11.74 85 92602 15812 90519948
Gastrointestinal disorder 70.09 11.74 96 92591 256591 90279169
Immune effector cell-associated neurotoxicity syndrome 69.27 11.74 53 92634 5715 90530045
Intentional product use issue 68.93 11.74 72 92615 216820 90318940
Platelet count decreased 68.69 11.74 300 92387 136669 90399091
Hypersensitivity 68.55 11.74 237 92450 454440 90081320
Erythema multiforme 68.23 11.74 73 92614 12173 90523587
Hepatic function abnormal 65.83 11.74 146 92541 46142 90489618
Septic embolus 65.78 11.74 28 92659 969 90534791
Toxic anterior segment syndrome 65.31 11.74 36 92651 2214 90533546
Muscular weakness 65.23 11.74 69 92618 206597 90329163
Asthenia 64.83 11.74 303 92384 533448 90002312
Scoliosis 64.12 11.74 61 92626 8846 90526914
Cytomegalovirus infection 64.04 11.74 105 92582 26497 90509263
Status epilepticus 63.32 11.74 87 92600 18787 90516973
Clostridial infection 63.28 11.74 46 92641 4590 90531170
Road traffic accident 63.26 11.74 16 92671 107610 90428150
Haemorrhagic occlusive retinal vasculitis 62.88 11.74 15 92672 67 90535693
Thrombotic microangiopathy 62.78 11.74 79 92608 15664 90520096
Autoimmune disorder 62.61 11.74 4 92683 76740 90459020
Blood alkaline phosphatase increased 61.03 11.74 145 92542 47934 90487826
Nonspecific reaction 60.44 11.74 37 92650 2772 90532988
Geotrichum infection 60.38 11.74 23 92664 593 90535167
Pulmonary fibrosis 59.42 11.74 18 92669 107485 90428275
Hip arthroplasty 59.24 11.74 5 92682 76203 90459557
Alanine aminotransferase increased 59.18 11.74 259 92428 118079 90417681
Decreased appetite 58.97 11.74 193 92494 376347 90159413
Product use issue 58.20 11.74 160 92527 329759 90206001
Device related sepsis 57.47 11.74 44 92643 4749 90531011
Drug abuse 57.42 11.74 8 92679 82339 90453421
Blood bilirubin increased 57.24 11.74 133 92554 43337 90492423
Anaphylactic shock 57.04 11.74 110 92577 31507 90504253
Fungal sepsis 57.04 11.74 29 92658 1512 90534248
Clostridium test positive 57.03 11.74 46 92641 5355 90530405
Intentional overdose 57.02 11.74 13 92674 93821 90441939
Renal tubular injury 56.66 11.74 27 92660 1222 90534538
Antibiotic level below therapeutic 56.52 11.74 12 92675 27 90535733
Sinus operation 55.82 11.74 36 92651 2955 90532805
Suicide attempt 55.82 11.74 6 92681 75393 90460367
Dermatitis exfoliative generalised 55.62 11.74 46 92641 5547 90530213
Fear 54.83 11.74 76 92611 16546 90519214
Anhedonia 54.82 11.74 63 92624 11368 90524392
Hypokalaemia 54.57 11.74 272 92415 130844 90404916
Staphylococcus test positive 54.56 11.74 41 92646 4304 90531456
Adverse event 54.35 11.74 26 92661 117392 90418368
Staphylococcal sepsis 54.17 11.74 57 92630 9326 90526434
Pulmonary haemorrhage 54.14 11.74 53 92634 7960 90527800
Bacterial sepsis 54.02 11.74 43 92644 4912 90530848
Heparin-induced thrombocytopenia 53.48 11.74 44 92643 5268 90530492
Blister 53.40 11.74 113 92574 254885 90280875
Aplasia 53.11 11.74 39 92648 3952 90531808
Feeling abnormal 52.58 11.74 56 92631 167179 90368581
Retinal haemorrhage 52.37 11.74 45 92642 5719 90530041
Coagulopathy 52.16 11.74 89 92598 23200 90512560
Clostridium colitis 52.00 11.74 30 92657 2015 90533745
Bronchitis 51.77 11.74 48 92639 152879 90382881
Trichosporon infection 51.38 11.74 18 92669 363 90535397
Shock haemorrhagic 51.32 11.74 63 92624 12182 90523578
Atrial fibrillation 51.30 11.74 271 92416 133340 90402420
Acidosis 50.93 11.74 64 92623 12672 90523088
Vascular device infection 50.91 11.74 62 92625 11890 90523870
Confusional state 50.62 11.74 213 92474 385992 90149768
Knee arthroplasty 49.60 11.74 12 92675 83170 90452590
Anuria 49.25 11.74 68 92619 14750 90521010
Weight decreased 48.89 11.74 211 92476 379699 90156061
Dialysis 48.63 11.74 59 92628 11270 90524490
Meningitis bacterial 48.55 11.74 27 92660 1690 90534070
Hepatic failure 48.47 11.74 118 92569 39610 90496150
Generalised oedema 48.31 11.74 77 92610 18976 90516784
Aspartate aminotransferase increased 48.24 11.74 221 92466 102716 90433044
Taste disorder 47.94 11.74 4 92683 61542 90474218
Balance disorder 47.27 11.74 20 92667 97060 90438700
Megacolon 47.22 11.74 29 92658 2185 90533575
Posterior reversible encephalopathy syndrome 46.94 11.74 83 92604 22256 90513504
Injection site erythema 46.85 11.74 21 92666 98481 90437279
Gamma-glutamyltransferase increased 46.60 11.74 113 92574 37839 90497921
Necrotising enterocolitis neonatal 46.57 11.74 15 92672 231 90535529
Diabetes insipidus 46.43 11.74 33 92654 3179 90532581
Mucosal inflammation 45.43 11.74 146 92541 57479 90478281
Suicidal ideation 45.34 11.74 10 92677 73845 90461915
Neutropenic colitis 45.27 11.74 36 92651 4107 90531653
Peritonitis 45.05 11.74 76 92611 19629 90516131
Upper respiratory tract infection 44.96 11.74 39 92648 128279 90407481
Pseudomonal bacteraemia 44.79 11.74 27 92660 1967 90533793
Injection site reaction 44.79 11.74 19 92668 92061 90443699
Pneumonia fungal 44.72 11.74 45 92642 6986 90528774
Prescribed overdose 44.60 11.74 22 92665 97603 90438157
Chest pain 44.58 11.74 172 92515 319473 90216287
Multiple-drug resistance 44.46 11.74 47 92640 7729 90528031
Retinal ischaemia 44.46 11.74 17 92670 443 90535317
Prothrombin time prolonged 43.77 11.74 52 92635 9720 90526040
Eosinophilic pneumonia 43.60 11.74 30 92657 2743 90533017
Enterococcus test positive 43.42 11.74 23 92664 1306 90534454
Rash pustular 43.12 11.74 47 92640 8002 90527758
Bone marrow failure 42.88 11.74 99 92588 32122 90503638
Wound infection 42.85 11.74 28 92659 106374 90429386
Factor V deficiency 42.33 11.74 11 92676 74 90535686
Osteoporosis 42.25 11.74 23 92664 96508 90439252
Pneumonia necrotising 42.12 11.74 18 92669 629 90535131
Amnesia 41.76 11.74 30 92657 108475 90427285
Disseminated mucormycosis 41.49 11.74 18 92669 653 90535107
Choroiditis 40.55 11.74 14 92673 270 90535490
Laryngitis 40.37 11.74 3 92684 50750 90485010
Lactic acidosis 39.91 11.74 128 92559 50335 90485425
Colitis 39.58 11.74 159 92528 69783 90465977
Tachypnoea 39.50 11.74 75 92612 21234 90514526
Abscess 39.45 11.74 70 92617 18821 90516939
Pulseless electrical activity 39.13 11.74 47 92640 8885 90526875
Capillary leak syndrome 39.01 11.74 28 92659 2739 90533021
Live birth 39.00 11.74 16 92671 79091 90456669
Foot deformity 38.87 11.74 7 92680 59644 90476116
Candida sepsis 38.73 11.74 23 92664 1630 90534130
Pneumonia klebsiella 38.60 11.74 29 92658 3043 90532717
Lupus-like syndrome 38.53 11.74 3 92684 48843 90486917
Glomerulonephritis membranoproliferative 37.65 11.74 14 92673 337 90535423
Exostosis 37.43 11.74 5 92682 53129 90482631
Intensive care unit acquired weakness 37.35 11.74 19 92668 992 90534768
Bone erosion 37.32 11.74 5 92682 53016 90482744
Eosinophilic pneumonia acute 37.22 11.74 17 92670 698 90535062
Blood culture positive 37.01 11.74 35 92652 5037 90530723
Cardio-respiratory arrest 36.90 11.74 145 92542 62995 90472765
Bacterial infection 36.83 11.74 77 92610 23367 90512393
Torsade de pointes 36.64 11.74 60 92627 15122 90520638
Acute myeloid leukaemia 36.24 11.74 71 92616 20569 90515191
Pseudopolyp 35.74 11.74 14 92673 390 90535370
Red blood cell sedimentation rate increased 35.68 11.74 20 92667 82575 90453185
Fibromuscular dysplasia 35.27 11.74 13 92674 305 90535455
Leukaemoid reaction 35.27 11.74 12 92675 221 90535539
Drug level below therapeutic 34.78 11.74 36 92651 5778 90529982
Crystalluria 34.50 11.74 15 92672 547 90535213
Coeliac disease 34.47 11.74 3 92684 44607 90491153
Joint dislocation 34.44 11.74 3 92684 44579 90491181
Necrosis 34.37 11.74 38 92649 6572 90529188
Dry skin 34.36 11.74 24 92663 88049 90447711
Lung disorder 34.31 11.74 63 92624 149820 90385940
Cognitive disorder 34.27 11.74 14 92673 69393 90466367
Hepatic cirrhosis 34.22 11.74 11 92676 63242 90472518
Hypernatraemia 34.13 11.74 45 92642 9342 90526418
Rib fracture 33.84 11.74 80 92607 26355 90509405
Diffuse cutaneous mastocytosis 33.67 11.74 8 92679 35 90535725
Leuconostoc infection 33.20 11.74 7 92680 15 90535745
Pregnancy 33.19 11.74 11 92676 62036 90473724
Injection site swelling 33.10 11.74 10 92677 59829 90475931
Sinus tachycardia 33.00 11.74 83 92604 28430 90507330
Neck pain 32.75 11.74 41 92646 113922 90421838
Bronchial anastomosis complication 32.74 11.74 9 92678 77 90535683
Inflammation 32.68 11.74 85 92602 178507 90357253
Pulmonary oedema 32.66 11.74 138 92549 61942 90473818
Weissella infection 32.60 11.74 7 92680 17 90535743
Purpura 32.47 11.74 56 92631 14722 90521038
Birdshot chorioretinopathy 32.34 11.74 9 92678 81 90535679
Sepsis syndrome 32.25 11.74 17 92670 956 90534804
Liver injury 32.13 11.74 80 92607 170487 90365273
Haemolytic anaemia 32.06 11.74 49 92638 11648 90524112
Metabolic encephalopathy 32.02 11.74 37 92650 6715 90529045
Brain abscess 31.94 11.74 25 92662 2787 90532973
Underdose 31.80 11.74 8 92679 54009 90481751
Circulatory collapse 31.48 11.74 75 92612 24829 90510931
Exfoliative rash 31.22 11.74 26 92661 3166 90532594
Retinal vascular occlusion 31.15 11.74 13 92674 428 90535332
Hepatosplenic candidiasis 31.12 11.74 12 92675 320 90535440
Dehiscence 31.05 11.74 10 92677 154 90535606
Pulmonary trichosporonosis 30.77 11.74 8 92679 54 90535706
Intervertebral discitis 30.73 11.74 30 92657 4490 90531270
Incorrect drug administration rate 30.63 11.74 32 92655 5191 90530569
Blood urea increased 30.57 11.74 84 92603 30329 90505431
Intentional product misuse 30.46 11.74 28 92659 89576 90446184
Spinal stroke 30.39 11.74 8 92679 57 90535703
Adenovirus infection 30.17 11.74 30 92657 4592 90531168
Abscess neck 30.16 11.74 15 92672 746 90535014
Electrocardiogram QT prolonged 29.91 11.74 150 92537 72306 90463454
Continuous haemodiafiltration 29.91 11.74 16 92671 927 90534833
Accidental exposure to product 29.81 11.74 4 92683 42362 90493398
Necrotising colitis 29.75 11.74 18 92669 1320 90534440
Hepatic cytolysis 29.71 11.74 84 92603 30832 90504928
Urinary tract infection pseudomonal 29.67 11.74 16 92671 942 90534818
Paraspinal abscess 29.61 11.74 11 92676 264 90535496
Graft versus host disease in gastrointestinal tract 29.60 11.74 29 92658 4359 90531401
Blood lactate dehydrogenase increased 29.50 11.74 75 92612 25857 90509903
Enterobacter infection 29.42 11.74 23 92664 2560 90533200
Chest discomfort 29.21 11.74 61 92626 138304 90397456
Hepatocellular injury 29.13 11.74 80 92607 28878 90506882
Visual impairment 29.10 11.74 57 92630 132308 90403452
Cataract 28.98 11.74 19 92668 72073 90463687
Suspected transmission of an infectious agent via product 28.81 11.74 12 92675 393 90535367
Umbilical erythema 28.74 11.74 8 92679 72 90535688
Lung infiltration 28.59 11.74 54 92633 15228 90520532
Cutaneous vasculitis 28.53 11.74 36 92651 7157 90528603
Exposure to allergen 28.39 11.74 13 92674 537 90535223
Bronchial obstruction 28.29 11.74 19 92668 1670 90534090
Fluid retention 28.24 11.74 29 92658 88062 90447698
Joint stiffness 28.22 11.74 23 92664 78019 90457741
Avian influenza 28.17 11.74 8 92679 78 90535682
Dyspnoea 27.95 11.74 687 92000 880268 89655492
Asthma 27.87 11.74 140 92547 242020 90293740
Central nervous system injury 27.63 11.74 9 92678 144 90535616
Onychomycosis 27.60 11.74 3 92684 37373 90498387
Blood creatine phosphokinase increased 27.54 11.74 87 92600 33936 90501824
Overgrowth fungal 27.51 11.74 9 92678 146 90535614
Myeloma cast nephropathy 27.07 11.74 9 92678 154 90535606
Infusion site necrosis 27.06 11.74 8 92679 91 90535669
Candida endophthalmitis 26.95 11.74 7 92680 47 90535713
Hyperaemia 26.84 11.74 22 92665 2620 90533140
Multiple sclerosis relapse 26.73 11.74 10 92677 52295 90483465
Seizure 26.30 11.74 255 92432 152374 90383386
Skin exfoliation 26.23 11.74 138 92549 67775 90467985
Cardiac valve vegetation 26.19 11.74 11 92676 368 90535392
Lactobacillus infection 26.16 11.74 8 92679 103 90535657
Toxic encephalopathy 26.07 11.74 38 92649 8661 90527099
Unmasking of previously unidentified disease 25.68 11.74 17 92670 1459 90534301
Myoclonus 25.62 11.74 59 92628 19109 90516651
Ventricular tachycardia 25.59 11.74 69 92618 24639 90511121
Thrombotic thrombocytopenic purpura 25.44 11.74 26 92661 4112 90531648
Back pain 25.38 11.74 205 92482 316970 90218790
Heart rate increased 25.37 11.74 200 92487 112702 90423058
Generalised tonic-clonic seizure 25.33 11.74 86 92601 34817 90500943
Jaundice 25.27 11.74 82 92605 32435 90503325
Enterococcal bacteraemia 25.16 11.74 19 92668 2009 90533751
Necrotising fasciitis 24.99 11.74 25 92662 3855 90531905
Generalised onset non-motor seizure 24.94 11.74 6 92681 28 90535732
Streptococcal infection 24.90 11.74 34 92653 7299 90528461
IgA nephropathy 24.84 11.74 14 92673 899 90534861
Immune thrombocytopenia 24.82 11.74 47 92640 13279 90522481
Procalcitonin increased 24.78 11.74 17 92670 1547 90534213
Lip oedema 24.70 11.74 27 92660 4612 90531148
Splenic injury 24.67 11.74 9 92678 205 90535555
Subperiosteal abscess 24.66 11.74 5 92682 8 90535752
Skin maceration 24.51 11.74 9 92678 209 90535551
Excessive eye blinking 24.35 11.74 16 92671 1356 90534404
Acute graft versus host disease 24.33 11.74 29 92658 5439 90530321
Poor quality product administered 24.30 11.74 25 92662 3983 90531777
Enterococcal sepsis 24.28 11.74 17 92670 1599 90534161
Henoch-Schonlein purpura 24.17 11.74 17 92670 1610 90534150
Eye excision 24.12 11.74 6 92681 33 90535727
Vomiting 24.10 11.74 618 92069 787675 89748085
Hypervolaemia 24.03 11.74 81 92606 32676 90503084
Meningitis 23.91 11.74 36 92651 8445 90527315
Basal cell carcinoma 23.86 11.74 3 92684 33386 90502374
Therapy naive 23.82 11.74 6 92681 35 90535725
Anaphylactoid reaction 23.78 11.74 26 92661 4442 90531318
Venoocclusive liver disease 23.78 11.74 30 92657 5963 90529797
Gastrointestinal haemorrhage 23.76 11.74 166 92521 90082 90445678
Pulmonary alveolar haemorrhage 23.76 11.74 30 92657 5968 90529792
CNS ventriculitis 23.55 11.74 9 92678 234 90535526
Allergic eosinophilia 23.55 11.74 4 92683 0 90535760
Vessel puncture site inflammation 23.55 11.74 4 92683 0 90535760
Walking aid user 23.50 11.74 4 92683 35502 90500258
Endometrial disorder 23.46 11.74 13 92674 808 90534952
Cross sensitivity reaction 23.34 11.74 21 92666 2836 90532924
Graft versus host disease in skin 23.30 11.74 24 92663 3829 90531931
Upper airway necrosis 23.27 11.74 6 92681 39 90535721
Serum ferritin increased 23.23 11.74 33 92654 7348 90528412
Rash macular 23.21 11.74 76 92611 30204 90505556
Adenovirus reactivation 23.20 11.74 9 92678 244 90535516
Renal tubular disorder 23.15 11.74 22 92665 3185 90532575
BK polyomavirus test positive 23.09 11.74 8 92679 156 90535604
Immune reconstitution inflammatory syndrome 23.01 11.74 32 92655 6987 90528773
Vision blurred 22.97 11.74 49 92638 110244 90425516
Drug level decreased 22.87 11.74 38 92649 9692 90526068
Factor V inhibition 22.76 11.74 8 92679 163 90535597
Extravasation 22.68 11.74 21 92666 2943 90532817
Fusarium infection 22.64 11.74 14 92673 1068 90534692
Intraventricular haemorrhage neonatal 22.60 11.74 9 92678 262 90535498
Glutamate dehydrogenase level abnormal 22.52 11.74 5 92682 15 90535745
Skin test positive 22.34 11.74 13 92674 887 90534873
Ear pain 22.14 11.74 16 92671 57686 90478074
Pseudomonas test positive 22.13 11.74 13 92674 903 90534857
Depressed mood 21.92 11.74 12 92675 50210 90485550
Injection site pruritus 21.90 11.74 14 92673 53820 90481940
Wheezing 21.86 11.74 148 92539 237932 90297828
Clostridial sepsis 21.84 11.74 11 92676 562 90535198
Premature delivery 21.83 11.74 88 92599 38674 90497086
Urine output decreased 21.70 11.74 43 92644 12560 90523200
Blood albumin decreased 21.67 11.74 51 92636 16752 90519008
Escherichia bacteraemia 21.64 11.74 28 92659 5707 90530053
Femur fracture 21.63 11.74 10 92677 46072 90489688
Lemierre syndrome 21.60 11.74 7 92680 110 90535650
Brain herniation 21.59 11.74 24 92663 4176 90531584
Lung abscess 21.59 11.74 18 92669 2195 90533565
Aggression 21.41 11.74 68 92619 26600 90509160
Renal disorder 21.36 11.74 86 92601 37773 90497987
Wound haemorrhage 21.33 11.74 20 92667 2847 90532913
Product quality issue 21.30 11.74 30 92657 79295 90456465
Complications of transplanted kidney 21.27 11.74 20 92667 2858 90532902
Pneumonia bacterial 21.26 11.74 43 92644 12747 90523013
Lymphadenopathy 21.23 11.74 98 92589 45677 90490083
Eosinophils urine present 21.21 11.74 5 92682 21 90535739
Unresponsive to stimuli 21.04 11.74 86 92601 38035 90497725
Empyema 20.98 11.74 18 92669 2282 90533478
Bronchopulmonary dysplasia 20.96 11.74 11 92676 613 90535147
Shunt infection 20.93 11.74 7 92680 122 90535638
Hepatitis cholestatic 20.89 11.74 34 92653 8527 90527233
Pneumococcal infection 20.84 11.74 14 92673 1231 90534529
Uterine fistula 20.67 11.74 5 92682 24 90535736
Candida test positive 20.62 11.74 13 92674 1026 90534734
Osteomyelitis 20.55 11.74 69 92618 27777 90507983
Petechiae 20.54 11.74 48 92639 15693 90520067
Ascites 20.53 11.74 100 92587 47640 90488120
Breast cancer 20.51 11.74 15 92672 53746 90482014
Antimicrobial susceptibility test resistant 20.50 11.74 5 92682 25 90535735
Systemic mycosis 20.47 11.74 15 92672 1515 90534245
Drug tolerance decreased 20.44 11.74 4 92683 32126 90503634
Rash pruritic 20.36 11.74 149 92538 82065 90453695
Anti factor Xa activity decreased 20.31 11.74 4 92683 5 90535755
Haemothorax 20.20 11.74 18 92669 2400 90533360
Hypertriglyceridaemia 20.16 11.74 32 92655 7857 90527903
Nervous system disorder 20.10 11.74 58 92629 21535 90514225
Chorioretinopathy 19.98 11.74 12 92675 868 90534892
Fungal endocarditis 19.97 11.74 9 92678 358 90535402
Intestinal ischaemia 19.96 11.74 34 92653 8849 90526911
Laryngeal stenosis 19.92 11.74 14 92673 1325 90534435
Periphlebitis 19.89 11.74 4 92683 6 90535754
Acantholysis 19.88 11.74 5 92682 29 90535731
Traumatic haemothorax 19.77 11.74 8 92679 243 90535517
Neurodevelopmental disorder 19.71 11.74 8 92679 245 90535515
Electrocardiogram repolarisation abnormality 19.57 11.74 14 92673 1362 90534398
Hypopyon 19.56 11.74 12 92675 902 90534858
Lymphocytic infiltration 19.56 11.74 13 92674 1123 90534637
Renal graft infection 19.54 11.74 9 92678 377 90535383
Eosinophil count increased 19.43 11.74 42 92645 13039 90522721
Epilepsy 19.31 11.74 34 92653 82172 90453588
Abscess limb 19.28 11.74 27 92660 5935 90529825
Lipase increased 19.24 11.74 38 92649 11073 90524687
Maternal exposure during pregnancy 19.24 11.74 256 92431 359807 90175953
Chills 19.18 11.74 213 92474 131768 90403992
Antithrombin III 19.16 11.74 7 92680 160 90535600
Herpes simplex test positive 19.02 11.74 9 92678 401 90535359
Pulse absent 18.95 11.74 27 92660 6028 90529732
Disability 18.88 11.74 9 92678 40736 90495024
Puerperal pyrexia 18.83 11.74 5 92682 37 90535723
Enterocolitis haemorrhagic 18.82 11.74 15 92672 1717 90534043
Pneumomediastinum 18.74 11.74 16 92671 2015 90533745
Infusion site streaking 18.73 11.74 10 92677 577 90535183
Hepatosplenomegaly 18.67 11.74 19 92668 2990 90532770
Neonatal disorder 18.65 11.74 10 92677 582 90535178
Peripheral sensorimotor neuropathy 18.65 11.74 16 92671 2029 90533731
Post procedural complication 18.55 11.74 52 92635 18990 90516770
Pulmonary mucormycosis 18.52 11.74 10 92677 590 90535170
Endocarditis candida 18.49 11.74 5 92682 40 90535720
Malnutrition 18.40 11.74 51 92636 18507 90517253
Rash 18.31 11.74 992 91695 795108 89740652
Morganella infection 18.20 11.74 11 92676 805 90534955
Injection site bruising 18.19 11.74 16 92671 52291 90483469
Cholangitis 18.17 11.74 29 92658 7153 90528607
Disease progression 18.08 11.74 242 92445 156373 90379387
Blastomycosis 18.01 11.74 9 92678 452 90535308
Encephalitis 17.99 11.74 37 92650 11097 90524663
Intentional self-injury 17.94 11.74 4 92683 29330 90506430
Neutrophil count decreased 17.92 11.74 130 92557 71402 90464358
Encephalitis Japanese B 17.87 11.74 5 92682 46 90535714
Eye allergy 17.84 11.74 13 92674 1302 90534458
Pseudomonal sepsis 17.81 11.74 22 92665 4280 90531480
Dysphonia 17.80 11.74 23 92664 63061 90472699
Gastrointestinal oedema 17.80 11.74 14 92673 1572 90534188
Meningitis staphylococcal 17.71 11.74 6 92681 109 90535651
Cystic fibrosis 17.70 11.74 21 92666 3920 90531840
Hepatitis fulminant 17.68 11.74 21 92666 3924 90531836
Activated partial thromboplastin time prolonged 17.65 11.74 30 92657 7795 90527965
Acute hepatic failure 17.63 11.74 57 92630 22504 90513256
Peritonitis bacterial 17.59 11.74 24 92663 5147 90530613
Nosocomial infection 17.51 11.74 15 92672 1898 90533862
Red cell distribution width abnormal 17.51 11.74 7 92680 206 90535554
Haemoptysis 17.47 11.74 74 92613 33246 90502514
Central nervous system vasculitis 17.44 11.74 12 92675 1097 90534663
Drug monitoring procedure incorrectly performed 17.37 11.74 8 92679 335 90535425
Hyperchloraemia 17.35 11.74 11 92676 877 90534883
Peripheral ischaemia 17.34 11.74 25 92662 5642 90530118
Diabetic gastroparesis 17.32 11.74 8 92679 337 90535423
Neonatal anuria 17.32 11.74 5 92682 52 90535708
Altered state of consciousness 17.29 11.74 71 92616 31461 90504299
Lower respiratory tract infection bacterial 17.21 11.74 9 92678 498 90535262
Amniotic cavity infection 17.14 11.74 13 92674 1383 90534377
Hypochromasia 17.13 11.74 8 92679 346 90535414
Cerebral infarction 17.12 11.74 63 92624 26533 90509227
Blood pressure fluctuation 17.09 11.74 17 92670 52396 90483364
Corneal opacity 17.09 11.74 11 92676 900 90534860
Haemolysis 17.09 11.74 31 92656 8479 90527281
Parenteral nutrition 16.87 11.74 7 92680 227 90535533
Tumour lysis syndrome 16.79 11.74 36 92651 11116 90524644
Back disorder 16.71 11.74 3 92684 25628 90510132
Epidermal necrosis 16.67 11.74 16 92671 2345 90533415
Burkholderia test positive 16.59 11.74 7 92680 237 90535523
Limbal swelling 16.57 11.74 4 92683 19 90535741
Haemostasis 16.51 11.74 8 92679 376 90535384
Febrile bone marrow aplasia 16.50 11.74 33 92654 9705 90526055
Cytomegalovirus infection reactivation 16.41 11.74 29 92658 7771 90527989
Fibrosis 16.41 11.74 25 92662 5927 90529833
Pneumonia cytomegaloviral 16.38 11.74 18 92669 3093 90532667
Haemorrhage intracranial 16.37 11.74 43 92644 15119 90520641
Electrocardiogram QRS complex prolonged 16.35 11.74 28 92659 7320 90528440
Clostridium bacteraemia 16.32 11.74 7 92680 247 90535513
Unevaluable event 16.31 11.74 104 92583 54744 90481016
Biliary sepsis 16.29 11.74 11 92676 975 90534785
Klebsiella test positive 16.29 11.74 13 92674 1490 90534270
Vertigo 16.28 11.74 29 92658 69782 90465978
Haematoma 16.23 11.74 81 92606 38967 90496793
Anaemia 16.21 11.74 474 92213 352328 90183432
Haemoperitoneum 16.17 11.74 19 92668 3509 90532251
Vulvovaginitis 16.16 11.74 8 92679 394 90535366
Disseminated coccidioidomycosis 16.15 11.74 6 92681 144 90535616
Adverse drug reaction 16.12 11.74 63 92624 116638 90419122
Muscle spasticity 16.07 11.74 8 92679 35314 90500446
Cough 16.04 11.74 273 92414 368689 90167071
Respiratory gas exchange disorder 16.03 11.74 8 92679 401 90535359
Abortion spontaneous 16.00 11.74 19 92668 54037 90481723
Hydrocephalus 15.96 11.74 25 92662 6069 90529691
Enterocolitis 15.95 11.74 34 92653 10456 90525304
Inappropriate schedule of product administration 15.94 11.74 89 92598 149844 90385916
Liquid product physical issue 15.94 11.74 13 92674 1537 90534223
Cellulitis 15.92 11.74 153 92534 91184 90444576
Emotional distress 15.91 11.74 77 92610 36585 90499175
Psychotic disorder 15.91 11.74 6 92681 31224 90504536
Hip fracture 15.80 11.74 7 92680 33070 90502690
Fluid balance positive 15.79 11.74 4 92683 24 90535736
Bandaemia 15.79 11.74 4 92683 24 90535736
Electrocardiogram ST segment elevation 15.77 11.74 20 92667 3996 90531764
Enterocutaneous fistula 15.77 11.74 13 92674 1561 90534199
Drug clearance decreased 15.60 11.74 14 92673 1884 90533876
Compartment syndrome 15.59 11.74 17 92670 2895 90532865
Citrobacter sepsis 15.58 11.74 3 92684 3 90535757
Injury 15.57 11.74 128 92559 197221 90338539
Bullous erysipelas 15.51 11.74 4 92683 26 90535734
Lung neoplasm malignant 15.49 11.74 3 92684 24270 90511490
Differentiation syndrome 15.48 11.74 12 92675 1319 90534441
Joint injury 15.47 11.74 7 92680 32657 90503103
Infectious pleural effusion 15.43 11.74 14 92673 1911 90533849
Abdominal abscess 15.38 11.74 23 92664 5364 90530396
Endocarditis staphylococcal 15.36 11.74 8 92679 439 90535321
Serratia sepsis 15.35 11.74 5 92682 80 90535680
Human herpesvirus 6 infection reactivation 15.32 11.74 9 92678 625 90535135
Fanconi syndrome 15.32 11.74 14 92673 1929 90533831
Holmes-Adie pupil 15.26 11.74 4 92683 28 90535732
Enterocolitis bacterial 15.24 11.74 7 92680 291 90535469
Procedural anxiety 15.23 11.74 10 92677 846 90534914
Endotracheal intubation 15.23 11.74 18 92669 3346 90532414
Hyperthermia 15.14 11.74 33 92654 10302 90525458
Thrombocytopenia neonatal 15.13 11.74 4 92683 29 90535731
Pancreatitis haemorrhagic 15.13 11.74 9 92678 640 90535120
Peritoneal effluent leukocyte count increased 15.12 11.74 3 92684 4 90535756
Histoplasmosis disseminated 15.12 11.74 15 92672 2290 90533470
Pulmonary necrosis 15.03 11.74 6 92681 176 90535584
Escherichia test positive 15.02 11.74 16 92671 2654 90533106
Dysgeusia 15.00 11.74 19 92668 52541 90483219
Hyperhidrosis 14.99 11.74 80 92607 136225 90399535
Vitreous opacities 14.98 11.74 8 92679 462 90535298
Supraventricular tachyarrhythmia 14.91 11.74 5 92682 88 90535672
Pulmonary hypertensive crisis 14.87 11.74 8 92679 469 90535291
Immunosuppressant drug level increased 14.84 11.74 21 92666 4659 90531101
Livedo reticularis 14.82 11.74 18 92669 3441 90532319
Arthritis bacterial 14.79 11.74 27 92660 7418 90528342
Implant site hypersensitivity 14.79 11.74 4 92683 32 90535728
Sneezing 14.79 11.74 6 92681 29863 90505897
Hospitalisation 14.76 11.74 74 92613 128026 90407734
Anal skin tags 14.74 11.74 9 92678 671 90535089
Asymptomatic bacteriuria 14.73 11.74 7 92680 315 90535445
Ureaplasma infection 14.73 11.74 10 92677 895 90534865
Organ failure 14.70 11.74 17 92670 3088 90532672
Liver abscess 14.67 11.74 18 92669 3478 90532282
Adverse reaction 14.66 11.74 6 92681 29706 90506054
Device dislocation 14.52 11.74 7 92680 31475 90504285
Abdominal sepsis 14.51 11.74 12 92675 1447 90534313
Epstein-Barr virus test positive 14.49 11.74 9 92678 692 90535068
Product contamination 14.48 11.74 11 92676 1173 90534587
Serum sickness 14.48 11.74 18 92669 3524 90532236
Hypoperfusion 14.35 11.74 13 92674 1771 90533989
Drug dependence 14.34 11.74 6 92681 29321 90506439
Lung consolidation 14.30 11.74 21 92666 4819 90530941
Respiratory tract oedema 14.24 11.74 9 92678 713 90535047
Electrocardiogram T wave alternans 14.18 11.74 4 92683 38 90535722
Gastrointestinal necrosis 14.18 11.74 17 92670 3208 90532552
Bacterial endophthalmitis 14.17 11.74 6 92681 205 90535555
Renal failure neonatal 14.17 11.74 6 92681 205 90535555
Myocardial infarction 14.13 11.74 58 92629 105914 90429846
Nephropathy 14.12 11.74 30 92657 9205 90526555
Plasmapheresis 14.11 11.74 7 92680 346 90535414
Movement disorder 14.09 11.74 6 92681 29013 90506747
Idiosyncratic drug reaction 14.09 11.74 10 92677 961 90534799
Drug trough level 14.09 11.74 4 92683 39 90535721
Congenital herpes simplex infection 14.05 11.74 3 92684 7 90535753
Uterine necrosis 14.05 11.74 3 92684 7 90535753
Chemical peritonitis 14.04 11.74 5 92682 106 90535654
Wrong technique in product usage process 13.92 11.74 33 92654 71538 90464222
Rhabdomyolysis 13.92 11.74 95 92592 51161 90484599
Vaginal abscess 13.91 11.74 8 92679 534 90535226
Maternal exposure timing unspecified 13.89 11.74 3 92684 22480 90513280
Blood pressure decreased 13.83 11.74 127 92560 74768 90460992
Haemolytic transfusion reaction 13.77 11.74 3 92684 8 90535752
Ischaemic enteritis 13.73 11.74 4 92683 43 90535717
Ear infection 13.70 11.74 32 92655 69743 90466017
Acne 13.67 11.74 6 92681 28501 90507259
Nervousness 13.65 11.74 9 92678 34047 90501713
Brain oedema 13.65 11.74 44 92643 17341 90518419
Drug chemical incompatibility 13.62 11.74 5 92682 116 90535644
Chronic obstructive pulmonary disease 13.61 11.74 35 92652 73794 90461966
Panic attack 13.54 11.74 5 92682 26360 90509400
Influenza like illness 13.52 11.74 40 92647 80571 90455189
Aortic thrombosis 13.49 11.74 11 92676 1301 90534459
Renal infarct 13.45 11.74 12 92675 1603 90534157
Culture urine positive 13.39 11.74 18 92669 3807 90531953
Distributive shock 13.36 11.74 17 92670 3407 90532353
Congestive hepatopathy 13.35 11.74 16 92671 3017 90532743
Large intestine infection 13.34 11.74 15 92672 2642 90533118
Superior sagittal sinus thrombosis 13.34 11.74 9 92678 797 90534963
Human herpesvirus 6 infection 13.33 11.74 17 92670 3415 90532345
Somnolence 13.32 11.74 143 92544 208941 90326819
Propofol infusion syndrome 13.29 11.74 11 92676 1328 90534432
Humoral immune defect 13.29 11.74 7 92680 393 90535367
Haemorrhagic pneumonia 13.27 11.74 3 92684 10 90535750
Myasthenia gravis crisis 13.27 11.74 10 92677 1054 90534706
Sleep apnoea syndrome 13.27 11.74 8 92679 31739 90504021
Cardiac tamponade 13.24 11.74 22 92665 5610 90530150
Carpal tunnel syndrome 13.23 11.74 4 92683 23924 90511836
Gastric disorder 13.15 11.74 9 92678 33375 90502385
Respiratory acidosis 13.14 11.74 27 92660 8092 90527668
Catheter site related reaction 13.13 11.74 10 92677 1071 90534689
Parasitic encephalitis 13.11 11.74 4 92683 51 90535709
Inflammatory marker increased 13.03 11.74 29 92658 9185 90526575
Immunodeficiency 13.01 11.74 15 92672 43219 90492541
Cardiac failure 12.97 11.74 170 92517 109326 90426434
Proctalgia 12.96 11.74 27 92660 8171 90527589
Transverse sinus thrombosis 12.95 11.74 8 92679 609 90535151
Cerebral ischaemia 12.93 11.74 25 92662 7171 90528589
Blood pressure systolic increased 12.93 11.74 25 92662 58320 90477440
Oedema mouth 12.90 11.74 14 92673 2372 90533388
Laryngeal inflammation 12.87 11.74 5 92682 136 90535624
Lymphocyte count 12.84 11.74 3 92684 12 90535748
Deafness bilateral 12.84 11.74 12 92675 1701 90534059
Bronchopleural fistula 12.81 11.74 6 92681 261 90535499
Renal abscess 12.81 11.74 10 92677 1111 90534649
Dyspnoea exertional 12.77 11.74 35 92652 72253 90463507
Hot flush 12.74 11.74 26 92661 59462 90476298
Tissue infiltration 12.72 11.74 9 92678 861 90534899
Infective aneurysm 12.69 11.74 7 92680 431 90535329
Parainfluenzae virus infection 12.69 11.74 15 92672 2788 90532972
Brain death 12.69 11.74 18 92669 4003 90531757
Gastric mucosal lesion 12.68 11.74 8 92679 632 90535128
Levator syndrome 12.65 11.74 3 92684 13 90535747
Renal impairment neonatal 12.64 11.74 4 92683 58 90535702
Manipulation 12.64 11.74 4 92683 58 90535702
Macroglossia 12.63 11.74 9 92678 870 90534890
Post procedural infection 12.57 11.74 32 92655 11042 90524718
Supraventricular tachycardia 12.52 11.74 41 92646 16295 90519465
Throat irritation 12.50 11.74 19 92668 48676 90487084
Acute lymphocytic leukaemia 12.50 11.74 15 92672 2833 90532927
Hypoacusis 12.45 11.74 59 92628 27791 90507969
Therapy interrupted 12.43 11.74 20 92667 50088 90485672
Meningococcal infection 12.42 11.74 5 92682 150 90535610
Histology abnormal 12.38 11.74 5 92682 151 90535609
Infection 12.36 11.74 279 92408 361815 90173945
Rhinovirus infection 12.33 11.74 22 92665 5941 90529819
Cystitis haemorrhagic 12.25 11.74 21 92666 5492 90530268
Thrombophlebitis septic 12.22 11.74 6 92681 290 90535470
Hypersensitivity vasculitis 12.22 11.74 18 92669 4141 90531619
Gastroenteritis viral 12.20 11.74 8 92679 30347 90505413
Herpes simplex 12.16 11.74 30 92657 10151 90525609
Heavy menstrual bleeding 12.16 11.74 3 92684 20527 90515233
Neonatal respiratory distress 12.14 11.74 8 92679 681 90535079
Wound infection bacterial 12.11 11.74 8 92679 684 90535076
Oedema mucosal 12.04 11.74 10 92677 1213 90534547
Granulomatous liver disease 12.02 11.74 9 92678 940 90534820
Cytomegalovirus viraemia 12.01 11.74 25 92662 7561 90528199
Retinal infarction 12.00 11.74 4 92683 69 90535691
Fibrin degradation products increased 12.00 11.74 5 92682 164 90535596
Osteomyelitis acute 11.94 11.74 6 92681 305 90535455
Quadriplegia 11.90 11.74 13 92674 2218 90533542
Premature baby 11.86 11.74 54 92633 25023 90510737
Haematidrosis 11.84 11.74 4 92683 72 90535688
Viral myositis 11.84 11.74 3 92684 18 90535742
Urinary tract infection enterococcal 11.81 11.74 15 92672 3001 90532759
Loss of personal independence in daily activities 11.80 11.74 86 92601 136019 90399741
Systolic dysfunction 11.77 11.74 12 92675 1892 90533868

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 2582.12 12.05 1484 103232 40591 42476028
Acute kidney injury 1453.54 12.05 2939 101777 364398 42152221
Linear IgA disease 1156.59 12.05 356 104360 1747 42514872
Drug ineffective 913.96 12.05 3491 101225 626706 41889913
Renal tubular necrosis 647.29 12.05 457 104259 17897 42498722
Multiple organ dysfunction syndrome 588.98 12.05 939 103777 96096 42420523
Septic shock 478.25 12.05 829 103887 90843 42425776
Eosinophilia 463.84 12.05 484 104232 32415 42484204
Rash maculo-papular 441.98 12.05 502 104214 37001 42479618
Fatigue 424.66 12.05 275 104441 435366 42081253
Toxic epidermal necrolysis 410.56 12.05 412 104304 26338 42490281
Tubulointerstitial nephritis 390.02 12.05 433 104283 31115 42485504
Nephropathy toxic 386.67 12.05 325 104391 16513 42500106
Pathogen resistance 384.96 12.05 277 104439 11173 42505446
Drug resistance 316.04 12.05 405 104311 33843 42482776
Drug ineffective for unapproved indication 305.11 12.05 465 104251 45698 42470921
Antibiotic level above therapeutic 304.10 12.05 88 104628 333 42516286
Fall 250.62 12.05 132 104584 234388 42282231
Dizziness 248.20 12.05 153 104563 249101 42267518
Acute generalised exanthematous pustulosis 246.48 12.05 189 104527 8406 42508213
Pyrexia 238.80 12.05 1719 102997 392323 42124296
Staphylococcal infection 234.46 12.05 369 104347 37274 42479345
Death 234.09 12.05 507 104209 470678 42045941
Product dose omission issue 224.45 12.05 52 104664 154313 42362306
Renal failure 224.17 12.05 819 103897 142907 42373712
Renal impairment 222.30 12.05 685 104031 109543 42407076
Drug abuse 221.94 12.05 8 104708 104763 42411856
Respiratory failure 216.80 12.05 750 103966 127382 42389237
Rash morbilliform 211.10 12.05 130 104586 4023 42512596
Candida infection 206.34 12.05 260 104456 21350 42495269
Antimicrobial susceptibility test resistant 200.74 12.05 63 104653 333 42516286
Enterococcal infection 194.96 12.05 191 104525 11848 42504771
Sepsis 194.91 12.05 986 103730 198348 42318271
Drug level increased 191.83 12.05 277 104439 25923 42490696
Arthralgia 181.66 12.05 143 104573 205095 42311524
Nausea 176.78 12.05 452 104264 396347 42120272
Clostridium difficile infection 173.88 12.05 245 104471 22414 42494205
Kounis syndrome 165.03 12.05 103 104613 3265 42513354
Stevens-Johnson syndrome 161.66 12.05 234 104482 21944 42494675
Acute respiratory distress syndrome 160.26 12.05 275 104441 29833 42486786
Systemic candida 159.20 12.05 120 104596 5199 42511420
Blood creatinine increased 155.76 12.05 608 104108 109395 42407224
Drug hypersensitivity 150.30 12.05 561 104155 98828 42417791
Haemophagocytic lymphohistiocytosis 150.28 12.05 204 104512 18018 42498601
Clostridium difficile colitis 150.21 12.05 221 104495 21031 42495588
Constipation 148.77 12.05 109 104607 162182 42354437
Weight decreased 144.70 12.05 179 104537 207769 42308850
Headache 144.68 12.05 228 104488 239141 42277478
Asthenia 143.31 12.05 297 104419 280496 42236123
Disseminated intravascular coagulation 141.98 12.05 234 104482 24560 42492059
Fungaemia 141.42 12.05 91 104625 3045 42513574
Aplastic anaemia 131.13 12.05 157 104559 12227 42504392
Toxic skin eruption 129.16 12.05 164 104552 13566 42503053
Thrombocytopenia 128.18 12.05 853 103863 189426 42327193
Haemodynamic instability 127.75 12.05 156 104560 12401 42504218
Condition aggravated 125.59 12.05 1080 103636 259674 42256945
Pseudomembranous colitis 124.48 12.05 84 104632 3049 42513570
Insomnia 122.57 12.05 69 104647 118184 42398435
Renal injury 122.41 12.05 151 104565 12129 42504490
Decreased appetite 121.43 12.05 179 104537 192958 42323661
Rash 120.52 12.05 1122 103594 275832 42240787
Immune thrombocytopenia 120.09 12.05 143 104573 11073 42505546
Choroiditis 118.90 12.05 61 104655 1314 42515305
Drug-induced liver injury 116.46 12.05 277 104439 37996 42478623
Muscle spasms 113.61 12.05 35 104681 86009 42430610
Anaphylactic reaction 109.75 12.05 290 104426 42453 42474166
Shock 109.08 12.05 229 104487 28892 42487727
Pain in extremity 107.49 12.05 127 104589 150477 42366142
Aspergillus infection 106.63 12.05 161 104555 15676 42500943
Nasopharyngitis 105.91 12.05 37 104679 83959 42432660
Drug eruption 103.92 12.05 196 104520 22879 42493740
Haemodialysis 103.62 12.05 127 104589 10133 42506486
Staphylococcal bacteraemia 103.29 12.05 132 104584 10989 42505630
Ototoxicity 101.23 12.05 66 104650 2259 42514360
Endocarditis 99.14 12.05 111 104605 8041 42508578
Injection site pain 98.00 12.05 13 104703 57785 42458834
Pancytopenia 94.29 12.05 552 104164 117191 42399428
Treatment failure 94.19 12.05 353 104363 62271 42454348
Bacteraemia 90.41 12.05 194 104522 24846 42491773
Retinal vasculitis 89.67 12.05 40 104676 623 42515996
Pseudomonas infection 89.43 12.05 149 104567 15774 42500845
Feeling abnormal 89.26 12.05 30 104686 69756 42446863
Weight increased 88.37 12.05 81 104635 107902 42408717
Depression 88.24 12.05 86 104630 111277 42405342
Rheumatoid arthritis 87.28 12.05 4 104712 42436 42474183
Encephalopathy 87.05 12.05 261 104455 41072 42475547
Gait disturbance 86.94 12.05 68 104648 97932 42418687
Dyspnoea 84.80 12.05 689 104027 441932 42074687
Abdominal discomfort 83.76 12.05 40 104676 75215 42441404
Megacolon 83.07 12.05 58 104658 2227 42514392
Musculoskeletal stiffness 82.80 12.05 20 104696 57745 42458874
Oliguria 82.51 12.05 108 104608 9205 42507414
Fear 81.80 12.05 117 104599 10848 42505771
Asthma 81.08 12.05 26 104690 62288 42454331
Prostate cancer 80.79 12.05 8 104708 44635 42471984
Coronary artery disease 80.21 12.05 17 104699 53703 42462916
Leukocytosis 79.78 12.05 205 104511 29503 42487116
Peripheral swelling 79.61 12.05 63 104653 90207 42426412
Off label use 79.22 12.05 2088 102628 636247 41880372
Suicide attempt 79.04 12.05 10 104706 46090 42470529
Hypotension 78.88 12.05 973 103743 256658 42259961
Klebsiella infection 78.85 12.05 117 104599 11215 42505404
Rash erythematous 78.61 12.05 214 104502 31877 42484742
Face oedema 78.25 12.05 129 104587 13537 42503082
Loss of personal independence in daily activities 78.09 12.05 14 104702 49802 42466817
Device related sepsis 77.02 12.05 69 104647 3818 42512801
Back pain 75.57 12.05 146 104570 141630 42374989
Joint swelling 74.42 12.05 37 104679 67985 42448634
Inappropriate schedule of product administration 73.75 12.05 76 104640 95826 42420793
Intentional overdose 73.39 12.05 18 104698 51438 42465181
Psoriasis 73.35 12.05 15 104701 48589 42468030
Hospitalisation 73.29 12.05 46 104670 74284 42442335
Minimum inhibitory concentration 73.10 12.05 24 104692 150 42516469
Myocardial infarction 73.03 12.05 120 104596 123889 42392730
Leukopenia 73.00 12.05 370 104346 74376 42442243
Myalgia 72.92 12.05 77 104639 96003 42420616
Malaise 72.63 12.05 272 104444 211884 42304735
Venoocclusive liver disease 72.59 12.05 107 104609 10195 42506424
Pain 70.80 12.05 335 104381 244513 42272106
Device related infection 70.79 12.05 155 104561 20124 42496495
Dry mouth 69.98 12.05 8 104708 39871 42476748
Vomiting 69.59 12.05 422 104294 289301 42227318
Diarrhoea 69.55 12.05 761 103955 460088 42056531
Drug dispensed to wrong patient 69.31 12.05 31 104685 486 42516133
Anhedonia 68.31 12.05 89 104627 7551 42509068
Jarisch-Herxheimer reaction 67.63 12.05 35 104681 768 42515851
Dehydration 66.38 12.05 157 104559 141610 42375009
Agranulocytosis 66.06 12.05 195 104521 30417 42486202
Geotrichum infection 66.06 12.05 31 104685 546 42516073
Fungal infection 65.76 12.05 148 104568 19574 42497045
Nephropathy 65.71 12.05 83 104633 6828 42509791
Memory impairment 65.25 12.05 21 104695 50201 42466418
Cutaneous vasculitis 64.61 12.05 82 104634 6778 42509841
Syncope 64.50 12.05 90 104626 99316 42417303
Cough 64.48 12.05 223 104493 177880 42338739
Neuropathy peripheral 64.32 12.05 94 104622 101759 42414860
Acute respiratory failure 64.30 12.05 226 104490 38632 42477987
Drug intolerance 63.82 12.05 62 104654 80362 42436257
Cardiac failure congestive 63.40 12.05 70 104646 85532 42431087
Therapy non-responder 62.17 12.05 278 104438 53081 42463538
Injury 62.00 12.05 156 104560 22160 42494459
Abdominal pain upper 61.79 12.05 67 104649 82542 42434077
Cardiac valve vegetation 61.73 12.05 29 104687 512 42516107
Thrombosis 61.44 12.05 47 104669 68464 42448155
Dry skin 61.42 12.05 21 104695 48317 42468302
Hepatocellular injury 61.12 12.05 161 104555 23517 42493102
Henoch-Schonlein purpura 61.02 12.05 47 104669 2103 42514516
Hypoxia 60.30 12.05 334 104382 69452 42447167
Endophthalmitis 60.24 12.05 64 104652 4369 42512250
Trichosporon infection 59.35 12.05 34 104682 918 42515701
Malignant neoplasm progression 59.18 12.05 110 104606 108290 42408329
Meningitis candida 58.86 12.05 20 104696 141 42516478
Transient ischaemic attack 58.62 12.05 7 104709 33732 42482887
Chest pain 58.04 12.05 164 104552 139366 42377253
Dialysis 57.97 12.05 105 104611 11881 42504738
Somnolence 57.86 12.05 167 104549 140938 42375681
Eosinophilic pneumonia 56.94 12.05 65 104651 4809 42511810
Dyspnoea exertional 56.80 12.05 26 104690 50122 42466497
Gastrooesophageal reflux disease 56.45 12.05 20 104696 45003 42471616
Dysbiosis 56.44 12.05 31 104685 770 42515849
Bronchopulmonary aspergillosis 56.27 12.05 138 104578 19291 42497328
Intentional product misuse 56.10 12.05 42 104674 61858 42454761
Tachycardia 55.65 12.05 432 104284 100655 42415964
Neurotoxicity 55.23 12.05 155 104561 23496 42493123
Cross sensitivity reaction 55.09 12.05 40 104676 1635 42514984
Blood culture positive 55.04 12.05 65 104651 4988 42511631
Emotional distress 55.03 12.05 122 104594 15971 42500648
Antibiotic level below therapeutic 54.99 12.05 16 104700 62 42516557
Hypoaesthesia 54.52 12.05 57 104659 71406 42445213
Mucormycosis 54.43 12.05 77 104639 7066 42509553
Dyspepsia 54.24 12.05 17 104699 41335 42475284
Septic embolus 54.22 12.05 37 104679 1368 42515251
Pneumonia staphylococcal 54.14 12.05 54 104662 3422 42513197
Therapeutic response delayed 53.92 12.05 29 104687 690 42515929
Blood cholesterol increased 53.46 12.05 3 104713 26738 42489881
Fungal endocarditis 53.34 12.05 25 104691 439 42516180
Myeloma cast nephropathy 53.08 12.05 17 104699 97 42516522
Suicidal ideation 52.97 12.05 26 104690 48135 42468484
Hypertension 52.97 12.05 221 104495 166983 42349636
Dermatitis bullous 52.76 12.05 83 104633 8373 42508246
Herpes simplex oesophagitis 52.68 12.05 21 104695 243 42516376
Purpura 52.36 12.05 100 104616 11779 42504840
Mental status changes 51.78 12.05 223 104493 41892 42474727
Blood glucose increased 51.63 12.05 63 104653 73636 42442983
Therapeutic product effect incomplete 51.45 12.05 59 104657 70880 42445739
Acinetobacter infection 51.35 12.05 37 104679 1494 42515125
Sleep disorder 51.35 12.05 27 104689 48068 42468551
Gout 50.83 12.05 5 104711 28050 42488569
Erythema 50.30 12.05 447 104269 108346 42408273
Cerebrovascular accident 50.07 12.05 102 104614 97058 42419561
Wrong technique in product usage process 50.04 12.05 21 104695 42614 42474005
Muscular weakness 49.89 12.05 80 104636 83418 42433201
Nightmare 49.41 12.05 3 104713 25009 42491610
Neutropenia 49.31 12.05 725 103991 198706 42317913
Myeloid maturation arrest 48.79 12.05 12 104704 19 42516600
Cardiac disorder 48.62 12.05 30 104686 48902 42467717
Nephrolithiasis 48.56 12.05 15 104701 36815 42479804
Chronic obstructive pulmonary disease 48.53 12.05 50 104666 63064 42453555
Enterococcal bacteraemia 48.27 12.05 45 104671 2622 42513997
Drug dependence 48.24 12.05 7 104709 29087 42487532
Therapeutic product effect decreased 48.05 12.05 18 104698 39132 42477487
Blood pressure increased 47.59 12.05 113 104603 101815 42414804
Disseminated mucormycosis 47.54 12.05 34 104682 1357 42515262
Dermatitis exfoliative 47.29 12.05 71 104645 6876 42509743
Anuria 47.09 12.05 94 104622 11438 42505181
COVID-19 46.96 12.05 138 104578 115810 42400809
Staphylococcal sepsis 46.56 12.05 93 104623 11321 42505298
Fungal peritonitis 46.55 12.05 29 104687 916 42515703
Type IV hypersensitivity reaction 45.81 12.05 42 104674 2395 42514224
Palpitations 45.34 12.05 35 104681 50762 42465857
Brain abscess 44.84 12.05 54 104662 4230 42512389
Diabetes mellitus 44.63 12.05 49 104667 60038 42456581
Organ failure 43.83 12.05 41 104675 2399 42514220
Erectile dysfunction 43.70 12.05 5 104711 24908 42491711
Skin necrosis 43.65 12.05 65 104651 6249 42510370
Balance disorder 43.59 12.05 32 104684 47613 42469006
Dermatitis exfoliative generalised 43.23 12.05 62 104654 5762 42510857
Transaminases increased 42.65 12.05 177 104539 32708 42483911
Anaphylactic shock 42.60 12.05 141 104575 23376 42493243
Hyper IgE syndrome 42.03 12.05 16 104700 162 42516457
Productive cough 41.78 12.05 39 104677 51528 42465091
Pulmonary embolism 41.76 12.05 152 104564 119460 42397159
Nephritis 41.70 12.05 49 104667 3740 42512879
Full blood count abnormal 41.54 12.05 11 104705 29865 42486754
Sleep apnoea syndrome 41.48 12.05 3 104713 21605 42495014
Coagulopathy 41.16 12.05 134 104582 22028 42494591
Cholestasis 41.11 12.05 175 104541 32704 42483915
Mechanical ventilation complication 40.86 12.05 24 104692 680 42515939
Procalcitonin increased 40.42 12.05 38 104678 2238 42514381
Migraine 40.14 12.05 7 104709 25407 42491212
Influenza 39.61 12.05 57 104659 62118 42454501
Staphylococcus test positive 39.40 12.05 47 104669 3645 42512974
Heparin-induced thrombocytopenia 38.75 12.05 63 104653 6534 42510085
Fungal sepsis 37.98 12.05 27 104689 1067 42515552
Hot flush 37.94 12.05 5 104711 22346 42494273
Depressed mood 37.91 12.05 6 104710 23378 42493241
Pneumonia fungal 37.88 12.05 75 104641 9071 42507548
Vision blurred 37.50 12.05 46 104670 53653 42462966
Arthropathy 37.35 12.05 13 104703 29584 42487035
Respiratory distress 37.35 12.05 202 104514 41618 42475001
Endocarditis candida 37.10 12.05 12 104704 71 42516548
Human herpesvirus 6 infection 37.08 12.05 38 104678 2487 42514132
Drug level above therapeutic 36.88 12.05 58 104658 5848 42510771
Loss of consciousness 36.60 12.05 111 104605 92243 42424376
Graft versus host disease 36.58 12.05 91 104625 12834 42503785
Stenotrophomonas infection 36.03 12.05 45 104671 3659 42512960
Cataract 36.03 12.05 15 104701 30589 42486030
Mobility decreased 35.98 12.05 21 104695 35285 42481334
Liver injury 35.76 12.05 116 104600 19032 42497587
Alveolar lung disease 35.67 12.05 19 104697 443 42516176
CNS ventriculitis 35.67 12.05 18 104698 374 42516245
Venoocclusive disease 35.61 12.05 46 104670 3869 42512750
Bronchitis 35.60 12.05 38 104678 47163 42469456
Product contamination 35.57 12.05 25 104691 970 42515649
Liver abscess 35.56 12.05 52 104664 4918 42511701
Nasal congestion 35.48 12.05 14 104702 29487 42487132
Generalised oedema 35.30 12.05 100 104616 15236 42501383
Eosinophilic pneumonia acute 35.10 12.05 23 104693 794 42515825
Contusion 34.91 12.05 31 104685 41954 42474665
Neck pain 34.87 12.05 15 104701 29999 42486620
Pulmonary interstitial emphysema syndrome 34.81 12.05 20 104696 543 42516076
Obstructive airways disorder 34.65 12.05 9 104707 24750 42491869
Erythema multiforme 34.52 12.05 76 104640 9901 42506718
Chest discomfort 34.31 12.05 65 104651 63551 42453068
Clostridium test positive 34.29 12.05 54 104662 5451 42511168
Overdose 34.01 12.05 138 104578 105126 42411493
Aggression 33.93 12.05 35 104681 44128 42472491
Osteoarthritis 33.91 12.05 9 104707 24396 42492223
Pollakiuria 33.84 12.05 7 104709 22498 42494121
Nervous system disorder 33.78 12.05 106 104610 17089 42499530
Rhinorrhoea 33.71 12.05 18 104698 31776 42484843
SJS-TEN overlap 33.69 12.05 21 104695 664 42515955
Accidental exposure to product 33.59 12.05 5 104711 20388 42496231
Cytomegalovirus enterocolitis 32.36 12.05 27 104689 1356 42515263
Enterococcal sepsis 32.29 12.05 32 104684 2012 42514607
Metabolic acidosis 32.14 12.05 228 104488 51630 42464989
Muscle abscess 32.09 12.05 23 104693 921 42515698
Intraocular pressure increased 31.93 12.05 57 104659 6376 42510243
Alopecia 31.89 12.05 16 104700 29260 42487359
Psychotic disorder 31.76 12.05 16 104700 29192 42487427
Histoplasmosis disseminated 31.68 12.05 32 104684 2059 42514560
Pyelonephritis fungal 31.62 12.05 11 104705 84 42516535
Enterococcus test positive 31.60 12.05 29 104687 1656 42514963
Arthritis 31.57 12.05 34 104682 42031 42474588
Vertigo 31.51 12.05 23 104693 34324 42482295
Dysgeusia 31.22 12.05 23 104693 34166 42482453
Petechiae 31.16 12.05 75 104641 10360 42506259
Diffuse alveolar damage 31.01 12.05 35 104681 2557 42514062
Dysuria 30.98 12.05 19 104697 31077 42485542
Influenza like illness 30.97 12.05 20 104696 31820 42484799
Benign prostatic hyperplasia 30.73 12.05 7 104709 21045 42495574
Urinary retention 30.72 12.05 35 104681 42179 42474440
Epidermolysis bullosa 30.64 12.05 12 104704 132 42516487
Gait inability 30.64 12.05 9 104707 22824 42493795
Basal cell carcinoma 30.43 12.05 9 104707 22724 42493895
Wheezing 30.40 12.05 55 104661 54726 42461893
Renal tubular injury 30.25 12.05 29 104687 1750 42514869
Vascular device infection 30.15 12.05 54 104662 6056 42510563
Systemic inflammatory response syndrome 29.88 12.05 60 104656 7330 42509289
Gastritis fungal 29.86 12.05 12 104704 142 42516477
Hypoglycaemia 29.85 12.05 64 104652 59790 42456829
Nocardiosis 29.72 12.05 49 104667 5141 42511478
Eosinophil count increased 29.64 12.05 75 104641 10688 42505931
Splenic abscess 29.44 12.05 19 104697 639 42515980
Meningitis fungal 29.40 12.05 13 104703 198 42516421
Hepatitis 29.39 12.05 139 104577 27161 42489458
Hypersensitivity vasculitis 29.33 12.05 38 104678 3206 42513413
Osteomyelitis 29.29 12.05 105 104611 18118 42498501
Fluid retention 29.23 12.05 21 104695 31598 42485021
Strongyloidiasis 29.18 12.05 39 104677 3392 42513227
Escherichia infection 28.91 12.05 77 104639 11319 42505300
Pulmonary haemorrhage 28.90 12.05 77 104639 11320 42505299
Intentional product use issue 28.70 12.05 86 104630 71747 42444872
Mycobacterial peritonitis 28.51 12.05 12 104704 161 42516458
Bladder cancer 28.50 12.05 4 104712 17043 42499576
Pneumothorax 28.42 12.05 124 104592 23419 42493200
Abdominal pain 28.39 12.05 315 104401 190156 42326463
Bronchiectasis 28.37 12.05 5 104711 18014 42498605
Aeromonas infection 28.35 12.05 15 104701 345 42516274
Prostatic specific antigen increased 28.22 12.05 4 104712 16921 42499698
Systemic mycosis 28.17 12.05 32 104684 2355 42514264
Aortoenteric fistula 28.01 12.05 11 104705 122 42516497
Presyncope 27.96 12.05 10 104706 22377 42494242
Hypoperfusion 27.95 12.05 25 104691 1380 42515239
Swelling 27.94 12.05 58 104658 54827 42461792
Upper respiratory tract infection 27.52 12.05 38 104678 42135 42474484
Cognitive disorder 27.50 12.05 26 104690 34146 42482473
Acidosis 27.23 12.05 79 104637 12200 42504419
Tremor 27.14 12.05 134 104582 96795 42419824
Neoplasm malignant 27.01 12.05 11 104705 22732 42493887
Enterobacter infection 26.86 12.05 35 104681 2969 42513650
Pleocytosis 26.83 12.05 18 104698 647 42515972
Multiple-drug resistance 26.73 12.05 57 104659 7265 42509354
Renal tubular disorder 26.32 12.05 45 104671 4864 42511755
Hypothyroidism 26.30 12.05 24 104692 32060 42484559
Drug level below therapeutic 26.30 12.05 53 104663 6492 42510127
Mycobacterium fortuitum infection 26.28 12.05 15 104701 402 42516217
Necrotising fasciitis 26.14 12.05 43 104673 4503 42512116
Neonatal cholestasis 25.95 12.05 9 104707 68 42516551
Pleural effusion 25.86 12.05 358 104358 96808 42419811
Brain herniation 25.58 12.05 44 104672 4779 42511840
Nosocomial infection 25.55 12.05 24 104692 1412 42515207
Drug trough level 25.45 12.05 6 104710 7 42516612
Hepatic function abnormal 25.44 12.05 215 104501 51352 42465267
Immune effector cell-associated neurotoxicity syndrome 25.09 12.05 65 104651 9396 42507223
Neuralgia 25.09 12.05 16 104700 25631 42490988
Dry eye 25.09 12.05 4 104712 15502 42501117
Pericarditis fungal 24.99 12.05 12 104704 223 42516396
Fusarium infection 24.97 12.05 25 104691 1591 42515028
Cutaneous mucormycosis 24.92 12.05 17 104699 628 42515991
Tachypnoea 24.57 12.05 112 104604 21550 42495069
Paraesthesia 24.55 12.05 95 104621 73364 42443255
Impaired quality of life 24.48 12.05 3 104713 14174 42502445
Haemothorax 24.22 12.05 45 104671 5191 42511428
Minimum inhibitory concentration increased 24.21 12.05 6 104710 10 42516609
Clostridial infection 24.13 12.05 38 104678 3836 42512783
Autoimmune haemolytic anaemia 24.09 12.05 47 104669 5624 42510995
Urticaria 24.03 12.05 283 104433 73753 42442866
Subperiosteal abscess 24.01 12.05 9 104707 87 42516532
Inflammatory marker increased 23.98 12.05 52 104664 6704 42509915
Orthostatic hypotension 23.74 12.05 24 104692 30546 42486073
Aminoaciduria 23.66 12.05 12 104704 252 42516367
General physical health deterioration 23.38 12.05 248 104468 150998 42365621
Hyperthermia 23.32 12.05 76 104640 12498 42504121
Foetal exposure during pregnancy 23.24 12.05 51 104665 47260 42469359
Immune reconstitution inflammatory syndrome 23.21 12.05 66 104650 10077 42506542
Device issue 22.98 12.05 3 104713 13506 42503113
Hyperammonaemia 22.91 12.05 56 104660 7810 42508809
Oedema peripheral 22.74 12.05 219 104497 135857 42380762
Abnormal behaviour 22.63 12.05 19 104697 26432 42490187
Hyponatraemia 22.63 12.05 151 104565 101311 42415308
Hypoalbuminaemia 22.63 12.05 87 104629 15523 42501096
Sedation 22.46 12.05 25 104691 30450 42486169
Pulseless electrical activity 22.41 12.05 58 104658 8379 42508240
Endocarditis bacterial 22.40 12.05 21 104695 1232 42515387
Lactobacillus infection 22.36 12.05 13 104703 361 42516258
Blood bilirubin increased 22.36 12.05 179 104537 42073 42474546
Myasthenia gravis 22.32 12.05 6 104710 16131 42500488
Diplopia 22.29 12.05 11 104705 20305 42496314
Corynebacterium infection 22.26 12.05 18 104698 865 42515754
Neoplasm progression 22.26 12.05 23 104693 28977 42487642
Noninfectious peritonitis 22.23 12.05 10 104706 159 42516460
Blood pressure fluctuation 22.21 12.05 20 104696 26888 42489731
Scedosporium infection 22.07 12.05 23 104693 1535 42515084
Product prescribing error 22.04 12.05 19 104697 26093 42490526
Cerebral cyst 22.03 12.05 12 104704 293 42516326
Mesangioproliferative glomerulonephritis 22.01 12.05 10 104706 163 42516456
Cutaneous T-cell lymphoma stage I 21.85 12.05 9 104707 114 42516505
Heart rate decreased 21.81 12.05 35 104681 36497 42480122
Hepatosplenic candidiasis 21.73 12.05 11 104705 230 42516389
Bone pain 21.73 12.05 16 104700 23776 42492843
Procalcitonin abnormal 21.71 12.05 13 104703 382 42516237
Glycosylated haemoglobin increased 21.68 12.05 3 104713 12921 42503698
Candida test positive 21.63 12.05 14 104702 473 42516146
Gingivitis ulcerative 21.61 12.05 11 104705 233 42516386
Hyperhidrosis 21.57 12.05 132 104584 90380 42426239
Eye pain 21.56 12.05 91 104625 16939 42499680
Urinary tract infection 21.53 12.05 149 104567 99135 42417484
Fungal test positive 21.53 12.05 15 104701 574 42516045
Intestinal obstruction 21.46 12.05 21 104695 27137 42489482
Pseudomonas test positive 21.45 12.05 22 104694 1441 42515178
Aspergillus test positive 21.39 12.05 16 104700 685 42515934
Disseminated cryptococcosis 21.36 12.05 25 104691 1900 42514719
Abdominal distension 21.35 12.05 97 104619 71638 42444981
Encephalomalacia 21.35 12.05 19 104697 1042 42515577
Head injury 21.31 12.05 12 104704 20570 42496049
Adverse drug reaction 21.30 12.05 37 104679 37397 42479222
Full blood count decreased 21.27 12.05 12 104704 20548 42496071
Cell death 21.23 12.05 31 104685 2928 42513691
Meningitis eosinophilic 20.88 12.05 6 104710 22 42516597
Irritability 20.81 12.05 23 104693 28105 42488514
Musculoskeletal pain 20.80 12.05 31 104685 33309 42483310
Hypernatraemia 20.78 12.05 63 104653 9969 42506650
Arteriosclerosis coronary artery 20.66 12.05 10 104706 18667 42497952
Proteus test positive 20.63 12.05 11 104705 257 42516362
Diabetic ketoacidosis 20.48 12.05 15 104701 22352 42494267
Crystalluria 20.43 12.05 16 104700 734 42515885
Intentional self-injury 20.38 12.05 6 104710 15196 42501423
Meningitis bacterial 20.32 12.05 21 104695 1388 42515231
Multiple sclerosis relapse 20.31 12.05 5 104711 14259 42502360
Blood urea increased 20.21 12.05 144 104572 32649 42483970
Cryptococcal meningoencephalitis 20.16 12.05 10 104706 200 42516419
Febrile neutropenia 20.14 12.05 598 104118 185105 42331514
Lung neoplasm malignant 20.06 12.05 11 104705 19136 42497483
Metastases to bone marrow 20.04 12.05 14 104702 538 42516081
Toxic shock syndrome 19.99 12.05 13 104703 443 42516176
Uveitis 19.99 12.05 59 104657 9199 42507420
Road traffic accident 19.96 12.05 11 104705 19082 42497537
Serotonin syndrome 19.89 12.05 120 104596 25725 42490894
Osteonecrosis of jaw 19.88 12.05 11 104705 19038 42497581
Sudden death 19.82 12.05 8 104708 16621 42499998
Pyroglutamic acidosis 19.78 12.05 16 104700 769 42515850
Injection site reaction 19.67 12.05 7 104709 15714 42500905
Unevaluable event 19.66 12.05 148 104568 34140 42482479
Vestibular disorder 19.66 12.05 19 104697 1158 42515461
Botulism 19.63 12.05 10 104706 212 42516407
Mediastinitis 19.62 12.05 18 104698 1027 42515592
Blood pressure systolic increased 19.48 12.05 24 104692 27944 42488675
Infective aneurysm 19.42 12.05 18 104698 1041 42515578
Urinary tract infection fungal 19.39 12.05 14 104702 567 42516052
Incorrect dose administered 19.35 12.05 66 104650 52908 42463711
Hyperbilirubinaemia 19.32 12.05 101 104615 20534 42496085
Cryptococcosis 19.32 12.05 31 104685 3180 42513439
Gastrointestinal disorder 19.25 12.05 55 104661 46598 42470021
Serratia bacteraemia 19.21 12.05 7 104709 62 42516557
Differentiation syndrome 19.21 12.05 23 104693 1790 42514829
Hypersomnia 19.18 12.05 6 104710 14612 42502007
Cardiac valve abscess 19.07 12.05 6 104710 32 42516587
Injection site haemorrhage 19.05 12.05 3 104713 11733 42504886
Illness 18.87 12.05 20 104696 24910 42491709
Diverticulitis 18.71 12.05 17 104699 22756 42493863
Cardiovascular somatic symptom disorder 18.62 12.05 6 104710 35 42516584
Sinusitis 18.61 12.05 57 104659 47235 42469384
Palmar-plantar erythrodysaesthesia syndrome 18.60 12.05 14 104702 20568 42496051
Haemorrhagic pneumonia 18.56 12.05 9 104707 171 42516448
Endocarditis staphylococcal 18.54 12.05 15 104701 721 42515898
Serum sickness-like reaction 18.51 12.05 10 104706 240 42516379
Ocular hyperaemia 18.51 12.05 8 104708 15955 42500664
Metastases to muscle 18.48 12.05 10 104706 241 42516378
Cardiac arrest 18.46 12.05 374 104342 108946 42407673
Angina unstable 18.42 12.05 3 104713 11445 42505174
Soft tissue necrosis 18.40 12.05 12 104704 411 42516208
Contraindicated product administered 18.33 12.05 21 104695 25251 42491368
Clostridium colitis 18.33 12.05 21 104695 1560 42515059
Bacterial endophthalmitis 18.27 12.05 8 104708 119 42516500
Herpes zoster 18.21 12.05 43 104673 38834 42477785
Dysphonia 18.20 12.05 26 104690 28424 42488195
Vitamin K deficiency 18.19 12.05 12 104704 419 42516200
Empyema 18.19 12.05 35 104681 4145 42512474
Rash macular 18.17 12.05 86 104630 16805 42499814
Hepatomegaly 18.17 12.05 67 104649 11718 42504901
Nutritional condition abnormal 18.08 12.05 13 104703 523 42516096
Janeway lesion 17.92 12.05 5 104711 16 42516603
Visual acuity reduced 17.91 12.05 88 104628 17462 42499157
Interstitial lung disease 17.88 12.05 116 104600 78346 42438273
Large intestinal ulcer haemorrhage 17.85 12.05 8 104708 126 42516493
Wrong rate 17.81 12.05 4 104712 3 42516616
Toxic shock syndrome staphylococcal 17.81 12.05 4 104712 3 42516616
Osteomyelitis fungal 17.81 12.05 11 104705 342 42516277
Nocturia 17.73 12.05 4 104712 12108 42504511
Metastases to retroperitoneum 17.73 12.05 10 104706 262 42516357
Oropharyngeal pain 17.63 12.05 50 104666 42460 42474159
Skin test positive 17.46 12.05 12 104704 449 42516170
Pulmonary fibrosis 17.45 12.05 24 104692 26657 42489962
Coronary artery occlusion 17.43 12.05 3 104713 10994 42505625
Bacterial pericarditis 17.41 12.05 7 104709 83 42516536
Prothrombin time prolonged 17.35 12.05 57 104659 9412 42507207
Rectal haemorrhage 17.32 12.05 63 104653 49543 42467076
Hepatic failure 17.30 12.05 156 104560 37944 42478675
Vascular purpura 17.30 12.05 24 104692 2162 42514457
Acne 17.20 12.05 6 104710 13638 42502981
Nephritis allergic 17.15 12.05 14 104702 682 42515937
Sepsis syndrome 16.97 12.05 15 104701 815 42515804
Pneumonia necrotising 16.94 12.05 17 104699 1085 42515534
Wrong patient received product 16.83 12.05 31 104685 3552 42513067
Acinetobacter test positive 16.79 12.05 8 104708 146 42516473
Toxic encephalopathy 16.65 12.05 46 104670 6907 42509712
Parkinsonism 16.61 12.05 3 104713 10620 42505999
Fixed eruption 16.59 12.05 25 104691 2429 42514190
Hyperlipidaemia 16.58 12.05 17 104699 21499 42495120
Progressive multifocal leukoencephalopathy 16.51 12.05 4 104712 11532 42505087
Antinuclear antibody negative 16.50 12.05 5 104711 23 42516596
Obesity 16.47 12.05 10 104706 16449 42500170
Hepatotoxicity 16.38 12.05 112 104604 25055 42491564
Clostridium bacteraemia 16.33 12.05 9 104707 225 42516394
Disseminated sporotrichosis 16.33 12.05 5 104711 24 42516595
Pulse absent 16.30 12.05 43 104673 6284 42510335
Infective keratitis 16.29 12.05 6 104710 55 42516564
Visual impairment 16.24 12.05 53 104663 43060 42473559
Cytokine release syndrome 16.17 12.05 174 104542 44353 42472266
Intervertebral discitis 16.14 12.05 28 104688 3062 42513557
Respiratory gas exchange disorder 16.14 12.05 12 104704 509 42516110
Platelet dysfunction 16.13 12.05 10 104706 313 42516306
Delusion 16.13 12.05 8 104708 14726 42501893
Unresponsive to stimuli 16.05 12.05 132 104584 31271 42485348
Central nervous system infection 16.02 12.05 15 104701 879 42515740
Disseminated strongyloidiasis 16.01 12.05 12 104704 515 42516104
Blood alkaline phosphatase increased 16.00 12.05 139 104577 33458 42483161
Quadriparesis 15.97 12.05 24 104692 2326 42514293
Anger 15.95 12.05 6 104710 13012 42503607
Necrotising enterocolitis neonatal 15.91 12.05 10 104706 321 42516298
Allergy test positive 15.91 12.05 8 104708 165 42516454
Posterior reversible encephalopathy syndrome 15.83 12.05 68 104648 12753 42503866
Arthrofibrosis 15.83 12.05 6 104710 60 42516559
Pneumonia mycoplasmal 15.76 12.05 14 104702 766 42515853
Masked fever 15.69 12.05 5 104711 28 42516591
Abscess 15.66 12.05 73 104643 14175 42502444
Extravasation 15.66 12.05 24 104692 2366 42514253
Liver transplant failure 15.64 12.05 7 104709 110 42516509
Myoclonus 15.62 12.05 83 104633 16982 42499637
Tooth disorder 15.57 12.05 5 104711 11974 42504645
Hernia 15.54 12.05 4 104712 11069 42505550
Injection site erythema 15.51 12.05 16 104700 20179 42496440
Haemolytic anaemia 15.50 12.05 65 104651 12062 42504557
Red blood cell schistocytes present 15.40 12.05 10 104706 340 42516279
Amnesia 15.38 12.05 29 104687 28408 42488211
Anaemia 15.31 12.05 549 104167 279729 42236890
Limb injury 15.31 12.05 8 104708 14297 42502322
Disseminated aspergillosis 15.23 12.05 20 104696 1710 42514909
Brain death 15.21 12.05 27 104689 3007 42513612
Discomfort 15.21 12.05 24 104692 25195 42491424
Suspected transmission of an infectious agent via product 15.19 12.05 15 104701 939 42515680
Continuous haemodiafiltration 15.19 12.05 15 104701 939 42515680
Asthma late onset 15.03 12.05 3 104713 0 42516619
Cardiac failure 15.01 12.05 179 104537 106677 42409942
Hallucination, auditory 14.92 12.05 9 104707 14855 42501764
Bone marrow failure 14.77 12.05 135 104581 32958 42483661
Bacterial sepsis 14.66 12.05 42 104674 6440 42510179
Oesophageal carcinoma 14.61 12.05 3 104713 9693 42506926
Joint injury 14.57 12.05 9 104707 14667 42501952
Therapy interrupted 14.56 12.05 20 104696 22230 42494389
Mania 14.44 12.05 4 104712 10543 42506076
Septic pulmonary embolism 14.44 12.05 7 104709 133 42516486
Liver disorder 14.43 12.05 155 104561 39489 42477130
Hypersensitivity 14.42 12.05 254 104462 72116 42444503
Double stranded DNA antibody positive 14.41 12.05 8 104708 203 42516416
Heart rate irregular 14.39 12.05 11 104705 16039 42500580
Plasma cell myeloma 14.36 12.05 64 104652 47514 42469105
Frequent bowel movements 14.26 12.05 19 104697 21388 42495231
Infective thrombosis 14.22 12.05 6 104710 81 42516538
Pancreatic carcinoma 14.20 12.05 3 104713 9503 42507116
Shock haemorrhagic 14.19 12.05 78 104638 16164 42500455
Product substitution issue 14.17 12.05 5 104711 11285 42505334
Alanine aminotransferase increased 14.12 12.05 300 104416 88106 42428513
Bacterial toxaemia 14.11 12.05 7 104709 140 42516479
Osteonecrosis 14.07 12.05 11 104705 15854 42500765
Poor quality sleep 14.06 12.05 3 104713 9437 42507182
Rib fracture 14.06 12.05 12 104704 16559 42500060
Metastases to central nervous system 14.04 12.05 4 104712 10351 42506268
White blood cell count increased 14.04 12.05 171 104545 44916 42471703
Abscess bacterial 14.03 12.05 8 104708 214 42516405
Platelet transfusion 14.01 12.05 19 104697 1675 42514944
Injection site pruritus 13.98 12.05 3 104713 9402 42507217
Pseudoendophthalmitis 13.96 12.05 6 104710 85 42516534
Hyperthyroidism 13.95 12.05 9 104707 14332 42502287
Glomerular filtration rate decreased 13.93 12.05 78 104638 16273 42500346
ADAMTS13 activity decreased 13.89 12.05 7 104709 145 42516474
Periostosis 13.85 12.05 4 104712 15 42516604
Corynebacterium sepsis 13.85 12.05 7 104709 146 42516473
Jaundice cholestatic 13.84 12.05 36 104680 5217 42511402
Speech disorder 13.81 12.05 32 104684 29089 42487530
Herpes dermatitis 13.80 12.05 7 104709 147 42516472
Wrong product administered 13.75 12.05 40 104676 6186 42510433
Taste disorder 13.74 12.05 4 104712 10203 42506416
Localised infection 13.65 12.05 18 104698 20355 42496264
Hallucination 13.63 12.05 84 104632 57423 42459196
Mycotic endophthalmitis 13.58 12.05 8 104708 228 42516391
Mucosal inflammation 13.57 12.05 183 104533 49191 42467428
Lung disorder 13.55 12.05 66 104650 47857 42468762
Spinal fracture 13.53 12.05 3 104713 9187 42507432
Deafness neurosensory 13.49 12.05 29 104687 3717 42512902
Metastases to bone 13.47 12.05 10 104706 14799 42501820
Rash pruritic 13.47 12.05 134 104582 33469 42483150
Withdrawal syndrome 13.41 12.05 10 104706 14765 42501854
Liquid product physical issue 13.40 12.05 13 104703 796 42515823
Rectal perforation 13.38 12.05 11 104705 541 42516078
Pneumonia pseudomonal 13.30 12.05 34 104682 4875 42511744
Stenotrophomonas test positive 13.28 12.05 9 104707 329 42516290
Movement disorder 13.27 12.05 10 104706 14688 42501931
Anxiety 13.27 12.05 208 104508 118352 42398267
Respiratory tract infection 13.24 12.05 28 104688 26294 42490325
Abscess fungal 13.13 12.05 9 104707 335 42516284
Leukoerythroblastosis 13.10 12.05 5 104711 51 42516568
Necrosis 13.06 12.05 41 104675 6610 42510009
Underdose 13.04 12.05 13 104703 16653 42499966
Heart rate increased 13.03 12.05 77 104639 53178 42463441
Arteriospasm coronary 13.03 12.05 33 104683 4705 42511914
Joint stiffness 13.03 12.05 7 104709 12315 42504304
Haemorrhagic vasculitis 12.96 12.05 3 104713 3 42516616
Sputum purulent 12.86 12.05 12 104704 700 42515919
Aortic pseudoaneurysm 12.85 12.05 5 104711 54 42516565
Interleukin-2 receptor increased 12.81 12.05 7 104709 172 42516447
Intraventricular haemorrhage 12.78 12.05 29 104687 3855 42512764
Hepatic vein occlusion 12.75 12.05 8 104708 256 42516363
Urinary incontinence 12.71 12.05 21 104695 21647 42494972
Colon cancer 12.66 12.05 4 104712 9677 42506942
Vanishing bile duct syndrome 12.56 12.05 19 104697 1852 42514767
Diabetes insipidus 12.53 12.05 28 104688 3685 42512934
Meningitis 12.52 12.05 37 104679 5772 42510847
Pulmonary resection 12.52 12.05 6 104710 111 42516508
Akathisia 12.50 12.05 5 104711 10446 42506173
Symptom masked 12.47 12.05 13 104703 868 42515751
Pulmonary pneumatocele 12.46 12.05 4 104712 23 42516596
Encephalitis 12.43 12.05 50 104666 9108 42507511
Subcutaneous emphysema 12.40 12.05 18 104698 1691 42514928
Gastric ulcer 12.37 12.05 16 104700 18246 42498373
Acute coronary syndrome 12.33 12.05 11 104705 14854 42501765
Angiopathy 12.31 12.05 35 104681 5342 42511277
Blood uric acid increased 12.31 12.05 12 104704 15535 42501084
Septic encephalopathy 12.29 12.05 7 104709 187 42516432
Pasteurella infection 12.28 12.05 6 104710 116 42516503
Distributive shock 12.24 12.05 22 104694 2474 42514145
Tetanus 12.23 12.05 5 104711 62 42516557
Pneumonia klebsiella 12.20 12.05 30 104686 4199 42512420
Cardiovascular disorder 12.19 12.05 9 104707 13356 42503263
Poor quality product administered 12.17 12.05 21 104695 2287 42514332
Gastrointestinal mucormycosis 12.10 12.05 9 104707 382 42516237
Complication of device removal 12.09 12.05 5 104711 64 42516555
Eczema 12.09 12.05 43 104673 34043 42482576
Panic attack 12.08 12.05 6 104710 11039 42505580
Malignant melanoma 12.08 12.05 4 104712 9396 42507223

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 5096.71 11.47 2545 178045 79550 110329159
Acute kidney injury 3606.06 11.47 4785 175805 630645 109778064
Linear IgA disease 2117.88 11.47 612 179978 3777 110404932
Drug ineffective 1542.12 11.47 5692 174898 1514848 108893861
Multiple organ dysfunction syndrome 1413.75 11.47 1478 179112 150232 110258477
Renal tubular necrosis 1341.13 11.47 752 179838 29723 110378986
Eosinophilia 1196.79 11.47 888 179702 57048 110351661
Septic shock 1155.32 11.47 1354 179236 156174 110252535
Nephropathy toxic 921.94 11.47 569 180021 26909 110381800
Toxic epidermal necrolysis 805.31 11.47 698 179892 56029 110352680
Rash maculo-papular 790.90 11.47 778 179812 73444 110335265
Pathogen resistance 782.61 11.47 438 180152 17234 110391475
Tubulointerstitial nephritis 758.59 11.47 662 179928 53622 110355087
Fatigue 752.26 11.47 537 180053 1215421 109193288
Acute generalised exanthematous pustulosis 684.84 11.47 432 180158 21232 110387477
Drug resistance 634.45 11.47 609 179981 55765 110352944
Renal failure 632.95 11.47 1241 179349 225333 110183376
Sepsis 631.12 11.47 1544 179046 325802 110082907
Drug ineffective for unapproved indication 586.84 11.47 780 179810 102058 110306651
Arthralgia 567.28 11.47 283 180307 779349 109629360
Antibiotic level above therapeutic 565.57 11.47 159 180431 874 110407835
Respiratory failure 557.77 11.47 1143 179447 214189 110194520
Clostridium difficile infection 532.25 11.47 534 180056 51595 110357114
Pyrexia 529.37 11.47 2871 177719 895394 109513315
Renal impairment 525.95 11.47 1032 179558 187413 110221296
Drug level increased 504.14 11.47 498 180092 47221 110361488
Joint swelling 488.55 11.47 71 180519 442774 109965935
Staphylococcal infection 469.16 11.47 575 180015 69369 110339340
Headache 448.12 11.47 469 180121 881908 109526801
Dizziness 437.56 11.47 303 180287 697890 109710819
Enterococcal infection 435.72 11.47 319 180271 20047 110388662
Synovitis 400.11 11.47 10 180580 274082 110134627
Arthropathy 396.67 11.47 17 180573 287505 110121204
Blood creatinine increased 390.25 11.47 898 179692 181991 110226718
Clostridium difficile colitis 383.18 11.47 413 180177 43365 110365344
Alopecia 380.84 11.47 68 180522 364685 110044024
Abdominal discomfort 367.31 11.47 95 180495 393763 110014946
Stevens-Johnson syndrome 366.58 11.47 417 180173 46484 110362225
Retinal vasculitis 360.18 11.47 133 180457 1916 110406793
Rheumatoid arthritis 352.18 11.47 39 180551 299574 110109135
Fall 345.78 11.47 287 180303 603195 109805514
Acute respiratory distress syndrome 336.95 11.47 425 180165 52773 110355936
Haemophagocytic lymphohistiocytosis 336.36 11.47 331 180259 31228 110377481
Rash morbilliform 335.59 11.47 191 180399 7760 110400949
Glossodynia 332.27 11.47 6 180584 221998 110186711
Pancytopenia 327.88 11.47 915 179675 208698 110200011
Toxic skin eruption 326.17 11.47 306 180284 27209 110381500
Pain 321.39 11.47 675 179915 954280 109454429
Thrombocytopenia 320.76 11.47 1272 179318 347613 110061096
Nasopharyngitis 314.81 11.47 125 180465 394236 110014473
Renal injury 312.48 11.47 253 180337 18460 110390249
Disseminated intravascular coagulation 309.04 11.47 359 180231 40927 110367782
Encephalopathy 306.64 11.47 507 180083 80548 110328161
Candida infection 303.19 11.47 383 180207 47626 110361083
Peripheral swelling 297.34 11.47 144 180446 403890 110004819
Contraindicated product administered 292.55 11.47 32 180558 248235 110160474
Swelling 285.57 11.47 108 180482 350933 110057776
Musculoskeletal stiffness 283.83 11.47 56 180534 279766 110128943
Psoriatic arthropathy 280.40 11.47 9 180581 196752 110211957
Insomnia 280.17 11.47 119 180471 360471 110048238
Product dose omission issue 278.96 11.47 89 180501 321693 110087016
Systemic lupus erythematosus 275.20 11.47 43 180547 254295 110154414
Pain in extremity 273.56 11.47 236 180354 486882 109921827
Shock 271.65 11.47 384 180206 53204 110355505
Nausea 269.67 11.47 1073 179517 1234617 109174092
Helicobacter infection 264 11.47 7 180583 181870 110226839
Weight increased 252.22 11.47 190 180400 419454 109989255
Hypotension 251.92 11.47 1589 179001 522260 109886449
Muscle spasms 251.86 11.47 71 180519 278086 110130623
Drug intolerance 249.56 11.47 180 180410 406332 110002377
Hypoaesthesia 248.43 11.47 101 180489 314122 110094587
Aplastic anaemia 248.04 11.47 249 180341 24059 110384650
Therapeutic product effect decreased 247.55 11.47 49 180541 244267 110164442
Dry mouth 240.12 11.47 24 180566 199924 110208785
Fibromyalgia 239.38 11.47 9 180581 170900 110237809
Wound 237.56 11.47 47 180543 234390 110174319
Staphylococcal bacteraemia 234.00 11.47 204 180386 16484 110392225
Malaise 233.18 11.47 466 180124 671353 109737356
Duodenal ulcer perforation 230.95 11.47 15 180575 177685 110231024
Abdominal pain upper 228.45 11.47 144 180446 348967 110059742
Drug abuse 227.58 11.47 16 180574 177395 110231314
Mobility decreased 225.60 11.47 55 180535 237367 110171342
Blood cholesterol increased 225.00 11.47 21 180569 184764 110223945
Pseudomembranous colitis 223.64 11.47 136 180454 6255 110402454
Fungaemia 219.39 11.47 132 180458 5954 110402755
Haemodynamic instability 218.17 11.47 226 180364 22662 110386047
Bacteraemia 216.69 11.47 305 180285 42085 110366624
Leukocytosis 213.45 11.47 344 180246 53484 110355225
Systemic candida 212.82 11.47 156 180434 9818 110398891
Anaphylactic reaction 212.20 11.47 532 180058 113768 110294941
Antimicrobial susceptibility test resistant 211.49 11.47 61 180529 373 110408336
Off label use 210.35 11.47 3524 177066 1496661 108912048
Irritable bowel syndrome 210.08 11.47 15 180575 164200 110244509
Sleep disorder 207.28 11.47 37 180553 198607 110210102
Memory impairment 207.00 11.47 36 180554 196908 110211801
Folliculitis 206.96 11.47 18 180572 167635 110241074
Asthenia 203.25 11.47 522 180068 688477 109720232
Pericarditis 201.95 11.47 54 180536 219060 110189649
Drug eruption 199.38 11.47 333 180257 53326 110355383
Gait disturbance 195.84 11.47 105 180485 278103 110130606
Klebsiella infection 195.10 11.47 200 180390 19809 110388900
Haemodialysis 192.83 11.47 188 180402 17531 110391178
Leukopenia 191.18 11.47 606 179984 148185 110260524
Injection site pain 190.36 11.47 31 180559 177891 110230818
Discomfort 190.30 11.47 57 180533 214650 110194059
Constipation 189.27 11.47 183 180407 357603 110051106
Endocarditis 188.58 11.47 164 180426 13207 110395502
Sinusitis 187.80 11.47 127 180463 296561 110112148
Osteoarthritis 186.30 11.47 36 180554 182587 110226122
Aspergillus infection 183.81 11.47 218 180372 25398 110383311
Pseudomonas infection 181.89 11.47 226 180364 27627 110381082
Neutropenia 178.40 11.47 1134 179456 373486 110035223
Endophthalmitis 176.83 11.47 129 180461 8058 110400651
Cholestasis 175.73 11.47 350 180240 64168 110344541
Agranulocytosis 175.43 11.47 341 180249 61419 110347290
Bursitis 174.83 11.47 9 180581 129909 110278800
Febrile neutropenia 174.47 11.47 996 179594 315771 110092938
Ototoxicity 173.70 11.47 99 180491 4032 110404677
Musculoskeletal pain 172.69 11.47 43 180547 182980 110225729
Hypoxia 170.52 11.47 532 180058 128983 110279726
Device related infection 169.75 11.47 262 180328 39257 110369452
Bronchopulmonary aspergillosis 169.43 11.47 226 180364 29637 110379072
Decreased appetite 169.32 11.47 325 180265 475521 109933188
Choroiditis 168.75 11.47 72 180518 1543 110407166
Mucormycosis 167.60 11.47 139 180451 10489 110398220
Type 2 diabetes mellitus 166.52 11.47 42 180548 177190 110231519
Contusion 165.81 11.47 87 180503 233274 110175435
Gastrooesophageal reflux disease 162.76 11.47 46 180544 179930 110228779
Kounis syndrome 162.26 11.47 108 180482 5817 110402892
Gait inability 162.08 11.47 17 180573 136359 110272350
Depression 161.31 11.47 168 180422 317167 110091542
Face oedema 159.60 11.47 233 180357 33236 110375473
C-reactive protein abnormal 157.18 11.47 15 180575 129680 110279029
Drug level above therapeutic 157.14 11.47 139 180451 11449 110397260
Acinetobacter infection 156.64 11.47 88 180502 3485 110405224
Ill-defined disorder 153.62 11.47 34 180556 156819 110251890
Dyspepsia 151.49 11.47 61 180529 190904 110217805
Hypertension 150.62 11.47 386 180204 509698 109899011
Weight decreased 150.22 11.47 339 180251 467718 109940991
Migraine 149.53 11.47 47 180543 171605 110237104
Neurotoxicity 148.94 11.47 256 180334 41951 110366758
Immune thrombocytopenia 147.66 11.47 183 180407 22311 110386398
Cardiac arrest 146.99 11.47 674 179916 196079 110212630
Impaired healing 144.75 11.47 70 180520 196647 110212062
Drug hypersensitivity 144.46 11.47 1249 179341 452841 109955868
Oliguria 142.57 11.47 164 180426 18493 110390216
Mental status changes 140.93 11.47 354 180236 75768 110332941
Arthritis 140.52 11.47 49 180541 167537 110241172
Dermatitis exfoliative 139.88 11.47 129 180461 11218 110397491
Acute respiratory failure 139.34 11.47 350 180240 74910 110333799
Psoriasis 137.79 11.47 30 180560 139963 110268746
Rash erythematous 136.55 11.47 366 180224 81466 110327243
Dysbiosis 134.63 11.47 67 180523 2065 110406644
Megacolon 133.91 11.47 85 180505 4220 110404489
Joint range of motion decreased 130.82 11.47 21 180569 121811 110286898
Bacterial disease carrier 130.68 11.47 67 180523 2202 110406507
Muscular weakness 130.29 11.47 128 180462 248340 110160369
Intentional overdose 129.19 11.47 29 180561 132472 110276237
Type IV hypersensitivity reaction 127.90 11.47 94 180496 5939 110402770
Obesity 127.59 11.47 17 180573 113334 110295375
Tachycardia 127.58 11.47 717 179873 225928 110182781
Feeling abnormal 127.43 11.47 68 180522 180643 110228066
Respiratory distress 127.19 11.47 320 180270 68554 110340155
Geotrichum infection 126.53 11.47 54 180536 1158 110407551
Dermatitis bullous 125.47 11.47 149 180441 17380 110391329
Lower respiratory tract infection 125.45 11.47 127 180463 242979 110165730
Fear 124.69 11.47 171 180419 23022 110385687
Transaminases increased 122.84 11.47 300 180290 63090 110345619
Erythema 122.81 11.47 856 179734 290591 110118118
Paraesthesia 122.70 11.47 163 180427 276358 110132351
Suicide attempt 122.58 11.47 13 180577 103381 110305328
Anhedonia 121.92 11.47 138 180452 15290 110393419
Gastrointestinal disorder 121.91 11.47 129 180461 241823 110166886
Night sweats 119.74 11.47 35 180555 133948 110274761
Sciatica 119.45 11.47 8 180582 92391 110316318
Peripheral venous disease 119.27 11.47 4 180586 84113 110324596
Device related sepsis 118.48 11.47 99 180491 7548 110401161
Systemic inflammatory response syndrome 117.54 11.47 125 180465 12918 110395791
Antibiotic level below therapeutic 117.35 11.47 28 180562 68 110408641
Vomiting 116.30 11.47 941 179649 909734 109498975
Septic embolus 114.95 11.47 62 180528 2264 110406445
Dialysis 113.64 11.47 150 180440 19469 110389240
Stenotrophomonas infection 112.45 11.47 86 180504 5772 110402937
Stomatitis 111.26 11.47 168 180422 270074 110138635
Pleural effusion 107.93 11.47 574 180016 177135 110231574
Cutaneous vasculitis 107.71 11.47 118 180472 12611 110396098
Dyspnoea 107.70 11.47 1223 179367 1105649 109303060
Superinfection 107.12 11.47 83 180507 5680 110403029
Trichosporon infection 106.94 11.47 49 180541 1251 110407458
Cytokine release syndrome 106.93 11.47 304 180286 70002 110338707
Metabolic acidosis 106.63 11.47 382 180208 99362 110309347
Hypercholesterolaemia 106.21 11.47 12 180578 90825 110317884
Infusion related reaction 105.97 11.47 297 180293 380865 110027844
Asthma 104.58 11.47 154 180436 250137 110158572
Road traffic accident 103.71 11.47 24 180566 107374 110301335
Intentional product use issue 101.19 11.47 155 180435 247751 110160958
Rash 100.92 11.47 1891 178699 819073 109589636
Grip strength decreased 100.60 11.47 8 180582 80166 110328543
Dermatitis exfoliative generalised 100.37 11.47 106 180484 10866 110397843
Injection site reaction 98.73 11.47 14 180576 89056 110319653
Haemorrhagic vasculitis 98.63 11.47 26 180564 107 110408602
Chest pain 98.29 11.47 302 180288 376073 110032636
Erythema multiforme 97.88 11.47 145 180445 20952 110387757
Graft versus host disease 97.12 11.47 136 180454 18670 110390039
Bronchitis 96.95 11.47 69 180521 156963 110251746
Anaphylactic shock 96.75 11.47 241 180349 51305 110357404
Eosinophilic pneumonia 96.62 11.47 86 180504 7141 110401568
Venoocclusive liver disease 95.48 11.47 121 180469 15086 110393623
Coagulopathy 95.10 11.47 208 180382 40703 110368006
Immune effector cell-associated neurotoxicity syndrome 95.01 11.47 119 180471 14663 110394046
Henoch-Schonlein purpura 93.78 11.47 64 180526 3593 110405116
Disseminated mucormycosis 92.77 11.47 52 180538 2050 110406659
Bronchial secretion retention 92.60 11.47 72 180518 4952 110403757
Clostridium test positive 92.20 11.47 101 180489 10792 110397917
Hepatocellular injury 91.11 11.47 233 180357 50409 110358300
Heparin-induced thrombocytopenia 89.96 11.47 102 180488 11322 110397387
Autoimmune disorder 89.82 11.47 4 180586 65479 110343230
Hepatic enzyme increased 89.21 11.47 250 180340 320642 110088067
Nephropathy 89.09 11.47 110 180480 13357 110395352
Back pain 89.04 11.47 309 180281 370687 110038022
Neck pain 88.77 11.47 45 180545 123085 110285624
Bronchospasm 88.35 11.47 169 180421 30070 110378639
Staphylococcal sepsis 88.32 11.47 125 180465 17329 110391380
Cardiac valve vegetation 88.07 11.47 40 180550 1000 110407709
Symmetrical drug-related intertriginous and flexural exanthema 86.65 11.47 48 180542 1849 110406860
Anuria 86.35 11.47 148 180442 24193 110384516
Blood culture positive 86.20 11.47 89 180501 8887 110399822
Lung disorder 84.13 11.47 102 180488 179945 110228764
Hepatic function abnormal 83.81 11.47 328 180262 88967 110319742
Escherichia infection 83.43 11.47 144 180446 23672 110385037
Minimum inhibitory concentration 82.90 11.47 24 180566 149 110408560
Multiple-drug resistance 82.60 11.47 105 180485 13130 110395579
Purpura 82.23 11.47 145 180445 24243 110384466
Fungal sepsis 81.88 11.47 49 180541 2188 110406521
Staphylococcus test positive 81.70 11.47 79 180511 7291 110401418
Pneumonia fungal 81.16 11.47 110 180480 14644 110394065
Renal tubular injury 81.14 11.47 55 180535 3053 110405656
Wheezing 80.86 11.47 186 180404 255044 110153665
Noninfectious peritonitis 80.79 11.47 27 180563 284 110408425
Hyperbilirubinaemia 80.65 11.47 164 180426 30507 110378202
Myeloma cast nephropathy 80.16 11.47 26 180564 247 110408462
Adverse event 78.09 11.47 40 180550 108769 110299940
Balance disorder 77.66 11.47 47 180543 116513 110292196
Pulmonary fibrosis 77.07 11.47 35 180555 102007 110306702
Upper respiratory tract infection 76.83 11.47 61 180529 131267 110277442
Hypoalbuminaemia 76.27 11.47 155 180435 28819 110379890
Brain abscess 75.82 11.47 73 180517 6701 110402008
Taste disorder 75.54 11.47 9 180581 65378 110343331
Pulmonary haemorrhage 74.76 11.47 112 180478 16344 110392365
Condition aggravated 74.75 11.47 1646 178944 733190 109675519
Cough 74.55 11.47 445 180145 461196 109947513
Enterococcal bacteraemia 73.81 11.47 60 180530 4401 110404308
Intentional product misuse 73.73 11.47 65 180525 132839 110275870
Dry skin 73.72 11.47 42 180548 107611 110301098
Blood bilirubin increased 73.69 11.47 282 180308 75690 110333019
Injection site erythema 73.18 11.47 31 180559 94145 110314564
Prescribed underdose 72.81 11.47 10 180580 65164 110343545
Injection site swelling 72.65 11.47 8 180582 61782 110346927
Death 72.26 11.47 761 179829 698108 109710601
Generalised oedema 71.24 11.47 156 180434 30548 110378161
Rhinocerebral mucormycosis 70.98 11.47 39 180551 1478 110407231
Drug-induced liver injury 70.96 11.47 385 180205 119682 110289027
Chest discomfort 70.64 11.47 109 180481 173739 110234970
Fungal endocarditis 70.31 11.47 32 180558 804 110407905
Jarisch-Herxheimer reaction 70.27 11.47 36 180554 1181 110407528
Eosinophilic pneumonia acute 70.27 11.47 40 180550 1625 110407084
Enterococcus test positive 70.18 11.47 49 180541 2855 110405854
Wound infection 69.92 11.47 35 180555 96430 110312279
Suicidal ideation 69.73 11.47 33 180557 93904 110314805
Prescribed overdose 69.39 11.47 28 180562 87553 110321156
Nervous system disorder 68.92 11.47 157 180433 31564 110377145
Vascular device infection 68.85 11.47 108 180482 16404 110392305
Hip arthroplasty 68.84 11.47 6 180584 55807 110352902
Drug dispensed to wrong patient 67.22 11.47 30 180560 719 110407990
Live birth 66.15 11.47 16 180574 69468 110339241
Knee arthroplasty 65.80 11.47 13 180577 64935 110343774
Blood alkaline phosphatase increased 65.30 11.47 259 180331 70676 110338033
Amnesia 64.16 11.47 47 180543 105361 110303348
Drug level below therapeutic 64.16 11.47 87 180503 11586 110397123
Osteoporosis 64.11 11.47 31 180559 87121 110321588
Clostridial infection 63.27 11.47 64 180526 6238 110402471
Alanine aminotransferase increased 62.82 11.47 514 180076 183259 110225450
Maternal exposure during pregnancy 62.68 11.47 210 180380 254673 110154036
Cross sensitivity reaction 62.32 11.47 60 180530 5507 110403202
Fungal peritonitis 61.82 11.47 34 180556 1291 110407418
Pneumonia staphylococcal 61.41 11.47 62 180528 6029 110402680
Pulseless electrical activity 60.91 11.47 103 180487 16654 110392055
Foot deformity 60.37 11.47 5 180585 48475 110360234
Hepatic failure 60.10 11.47 247 180343 68492 110340217
Platelet count decreased 59.68 11.47 607 179983 229836 110178873
Shock haemorrhagic 59.36 11.47 135 180455 27112 110381597
Loss of personal independence in daily activities 59.11 11.47 96 180494 149924 110258785
Crystal nephropathy 58.61 11.47 37 180553 1819 110406890
Blood urea increased 58.32 11.47 210 180380 54747 110353962
Coeliac disease 58.06 11.47 3 180587 43184 110365525
Cytomegalovirus infection 57.74 11.47 208 180382 54236 110354473
Acidosis 57.50 11.47 119 180471 22412 110386297
Cognitive disorder 57.30 11.47 36 180554 87475 110321234
Diarrhoea 57.17 11.47 1421 179169 1138084 109270625
Inappropriate schedule of product administration 57.04 11.47 158 180432 203479 110205230
Immune reconstitution inflammatory syndrome 56.69 11.47 98 180492 16128 110392581
Pregnancy 56.65 11.47 8 180582 51059 110357650
Vision blurred 56.23 11.47 77 180513 128945 110279764
Atelectasis 56.07 11.47 159 180431 36553 110372156
Emotional distress 56.04 11.47 181 180409 44666 110364043
Unevaluable event 55.93 11.47 218 180372 59009 110349700
Diabetes insipidus 55.75 11.47 61 180529 6509 110402200
Liver abscess 55.74 11.47 66 180524 7673 110401036
Procalcitonin increased 55.69 11.47 49 180541 4007 110404702
Dyspnoea exertional 55.22 11.47 53 180537 104007 110304702
Accidental exposure to product 55.09 11.47 8 180582 50000 110358709
Pneumonia necrotising 55.09 11.47 35 180555 1740 110406969
Pneumothorax 55.04 11.47 154 180436 35131 110373578
Drug interaction 54.83 11.47 1133 179457 499050 109909659
Prothrombin time prolonged 54.83 11.47 100 180490 17161 110391548
Meningitis candida 54.75 11.47 19 180571 226 110408483
Mucosal inflammation 54.60 11.47 305 180285 95836 110312873
Bone erosion 54.52 11.47 6 180584 46365 110362344
Cataract 54.43 11.47 31 180559 79454 110329255
Somnolence 54.41 11.47 275 180315 297174 110111535
Depressed mood 54.11 11.47 16 180574 60793 110347916
Exostosis 53.90 11.47 6 180584 45950 110362759
Fungal infection 53.79 11.47 194 180396 50612 110358097
Meningitis bacterial 53.59 11.47 43 180547 3096 110405613
Hospitalisation 53.54 11.47 94 180496 142399 110266310
Syncope 53.19 11.47 162 180428 202374 110206335
Crystalluria 53.05 11.47 31 180559 1324 110407385
Herpes simplex oesophagitis 52.87 11.47 22 180568 442 110408267
Haemolytic anaemia 52.81 11.47 110 180480 20810 110387899
Haemorrhagic occlusive retinal vasculitis 52.67 11.47 15 180575 87 110408622
Underdose 52.54 11.47 19 180571 63535 110345174
Fluid retention 52.45 11.47 46 180544 94261 110314448
Product contamination 52.40 11.47 35 180555 1896 110406813
Haemothorax 52.37 11.47 61 180529 6970 110401739
Organ failure 52.20 11.47 51 180539 4766 110403943
Toxic anterior segment syndrome 52.03 11.47 44 180546 3410 110405299
Hypernatraemia 51.28 11.47 99 180491 17734 110390975
Eosinophil count increased 51.15 11.47 109 180481 20949 110387760
Laryngitis 51.13 11.47 5 180585 42406 110366303
Posterior reversible encephalopathy syndrome 51.07 11.47 146 180444 33715 110374994
Tachypnoea 51.05 11.47 161 180429 39234 110369475
Mechanical ventilation complication 50.97 11.47 25 180565 746 110407963
Nocardiosis 50.90 11.47 62 180528 7424 110401285
Drug dependence 50.69 11.47 10 180580 50010 110358699
Bone marrow failure 50.68 11.47 208 180382 57640 110351069
Venoocclusive disease 50.51 11.47 57 180533 6293 110402416
Petechiae 50.21 11.47 115 180475 23202 110385507
Brain herniation 50.15 11.47 67 180523 8796 110399913
Systemic mycosis 50.07 11.47 45 180545 3784 110404925
Transient ischaemic attack 49.81 11.47 21 180569 63961 110344748
Fusarium infection 49.53 11.47 39 180551 2732 110405977
Enterococcal sepsis 49.50 11.47 42 180548 3270 110405439
Joint stiffness 49.33 11.47 24 180566 67219 110341490
Wrong technique in product usage process 49.32 11.47 42 180548 87306 110321403
Hyperthermia 49.26 11.47 108 180482 21164 110387545
Rash macular 49.13 11.47 157 180433 38529 110370180
Lupus-like syndrome 48.68 11.47 5 180585 40787 110367922
CNS ventriculitis 48.64 11.47 23 180567 632 110408077
Inflammation 48.33 11.47 158 180432 193080 110215629
Hepatosplenic candidiasis 48.28 11.47 23 180567 643 110408066
Incorrect drug administration rate 48.24 11.47 52 180538 5456 110403253
Hot flush 47.79 11.47 24 180566 66012 110342697
Enterobacter infection 47.66 11.47 53 180537 5758 110402951
Vertigo 47.56 11.47 43 180547 86827 110321882
Histoplasmosis disseminated 47.43 11.47 44 180546 3855 110404854
Bacterial sepsis 47.42 11.47 71 180519 10355 110398354
Myocardial infarction 47.39 11.47 158 180432 191925 110216784
Rhinorrhoea 47.07 11.47 59 180531 102607 110306102
Nasal congestion 46.62 11.47 55 180535 98227 110310482
Nonspecific reaction 45.98 11.47 39 180551 3035 110405674
Abscess 45.95 11.47 123 180467 27346 110381363
Sepsis syndrome 45.91 11.47 30 180560 1566 110407143
Osteonecrosis of jaw 45.82 11.47 11 180579 48006 110360703
Hypersensitivity 45.81 11.47 430 180160 403568 110005141
Nephritis 45.38 11.47 53 180537 6073 110402636
Necrosis 45.35 11.47 73 180517 11333 110397376
Strongyloidiasis 45.31 11.47 48 180542 4938 110403771
Osteomyelitis 45.09 11.47 147 180443 36453 110372256
Renal tubular disorder 44.89 11.47 58 180532 7371 110401338
Chronic obstructive pulmonary disease 44.76 11.47 68 180522 109090 110299619
Aspartate aminotransferase increased 44.66 11.47 428 180162 159508 110249201
Therapeutic response delayed 44.62 11.47 28 180562 1362 110407347
Blister 44.61 11.47 205 180385 227171 110181538
Basal cell carcinoma 43.93 11.47 10 180580 45260 110363449
Necrotising fasciitis 43.90 11.47 58 180532 7533 110401176
Pneumonia klebsiella 43.60 11.47 54 180536 6578 110402131
Blood pressure fluctuation 43.45 11.47 35 180555 74789 110333920
Scoliosis 43.38 11.47 62 180528 8671 110400038
Confusional state 43.38 11.47 523 180067 468157 109940552
Multiple sclerosis relapse 43.30 11.47 14 180576 50226 110358483
Hypersensitivity vasculitis 43.24 11.47 55 180535 6882 110401827
Injection site pruritus 42.93 11.47 15 180575 51243 110357466
Myoclonus 42.89 11.47 135 180455 32863 110375846
Empyema 42.62 11.47 49 180541 5521 110403188
Red blood cell sedimentation rate increased 42.58 11.47 39 180551 78263 110330446
Visual impairment 42.53 11.47 98 180492 134330 110274379
Human herpesvirus 6 infection 42.32 11.47 53 180537 6528 110402181
Ear pain 42.19 11.47 17 180573 53209 110355500
Myalgia 42.15 11.47 203 180387 222178 110186531
Pulmonary interstitial emphysema syndrome 42.11 11.47 20 180570 555 110408154
Endocarditis candida 42.05 11.47 13 180577 104 110408605
Pseudomonas test positive 41.80 11.47 33 180557 2321 110406388
Subperiosteal abscess 41.65 11.47 12 180578 73 110408636
Thrombotic microangiopathy 41.39 11.47 123 180467 29026 110379683
Gamma-glutamyltransferase increased 41.35 11.47 204 180386 61105 110347604
Injection site bruising 41.25 11.47 16 180574 51247 110357462
Nightmare 41.04 11.47 7 180583 38856 110369853
Lactobacillus infection 40.90 11.47 19 180571 501 110408208
Retinal haemorrhage 40.81 11.47 63 180527 9438 110399271
Sinus operation 40.80 11.47 36 180554 2955 110405754
Nosocomial infection 40.66 11.47 37 180553 3162 110405547
Diffuse alveolar damage 40.45 11.47 41 180549 4006 110404703
Rash pustular 40.34 11.47 74 180516 12755 110395954
Factor V deficiency 40.21 11.47 12 180578 84 110408625
Leukaemoid reaction 40.16 11.47 18 180572 436 110408273
Blood glucose increased 40.00 11.47 99 180491 132397 110276312
Myeloid maturation arrest 39.99 11.47 11 180579 55 110408654
Coronary artery disease 39.83 11.47 35 180555 71655 110337054
Autoimmune haemolytic anaemia 39.80 11.47 66 180524 10501 110398208
Pseudomonal bacteraemia 39.58 11.47 42 180548 4329 110404380
Suspected transmission of an infectious agent via product 39.50 11.47 26 180564 1374 110407335
Serotonin syndrome 39.31 11.47 196 180394 58957 110349752
Influenza like illness 39.30 11.47 52 180538 88360 110320349
Prostate cancer 39.27 11.47 7 180583 37634 110371075
Sleep apnoea syndrome 39.12 11.47 9 180581 40438 110368271
Dysgeusia 39.08 11.47 34 180556 69951 110338758
Blood pressure systolic increased 38.77 11.47 47 180543 82944 110325765
Muscle abscess 38.36 11.47 26 180564 1443 110407266
Intervertebral discitis 38.27 11.47 52 180538 6938 110401771
Neutropenic colitis 38.23 11.47 56 180534 8009 110400700
Blood pressure increased 38.09 11.47 256 180334 258117 110150592
Unresponsive to stimuli 37.98 11.47 205 180385 63585 110345124
Abdominal distension 37.94 11.47 152 180438 174951 110233758
Alveolar lung disease 37.88 11.47 20 180570 699 110408010
Graft versus host disease in gastrointestinal tract 37.87 11.47 59 180531 8909 110399800
Therapy non-responder 37.71 11.47 408 180182 156899 110251810
Therapeutic product effect incomplete 37.54 11.47 213 180377 223592 110185117
Status epilepticus 37.28 11.47 125 180465 31446 110377263
Influenza 37.14 11.47 146 180444 168955 110239754
Lung infiltration 36.96 11.47 106 180484 24522 110384187
Serum ferritin increased 36.83 11.47 68 180522 11779 110396930
Retinal ischaemia 36.71 11.47 22 180568 985 110407724
Pulse absent 36.61 11.47 66 180524 11226 110397483
Dysphonia 36.54 11.47 42 180548 75887 110332822
Inflammatory marker increased 36.43 11.47 76 180514 14393 110394316
Onychomycosis 36.43 11.47 9 180581 38522 110370187
Mycobacterial peritonitis 36.28 11.47 14 180576 229 110408480
Disseminated cryptococcosis 36.28 11.47 32 180558 2625 110406084
Meningitis 36.17 11.47 67 180523 11635 110397074
Psychotic disorder 36.14 11.47 19 180571 50918 110357791
Streptococcal infection 35.75 11.47 64 180526 10826 110397883
Infective aneurysm 35.65 11.47 25 180565 1467 110407242
Diffuse cutaneous mastocytosis 35.62 11.47 9 180581 30 110408679
Skin exfoliation 35.43 11.47 255 180335 87396 110321313
Candida test positive 35.43 11.47 24 180566 1331 110407378
Thrombosis 35.36 11.47 78 180512 108584 110300125
Hepatic cirrhosis 35.23 11.47 35 180555 67591 110341118
Hypokalaemia 34.82 11.47 453 180137 181995 110226714
Extravasation 34.37 11.47 41 180549 4804 110403905
Scedosporium infection 34.36 11.47 30 180560 2428 110406281
Aeromonas infection 34.28 11.47 17 180573 520 110408189
Splenic abscess 34.27 11.47 21 180569 979 110407730
Cytomegalovirus enterocolitis 34.24 11.47 29 180561 2252 110406457
Full blood count abnormal 34.10 11.47 25 180565 56027 110352682
COVID-19 34.06 11.47 247 180343 244813 110163896
Toxic encephalopathy 33.83 11.47 76 180514 15138 110393571
Dry eye 33.79 11.47 25 180565 55768 110352941
Torsade de pointes 33.65 11.47 97 180493 22503 110386206
Haemolysis 33.53 11.47 77 180513 15562 110393147
Aplasia 33.53 11.47 52 180538 7821 110400888
Acne 33.35 11.47 7 180583 33513 110375196
Anaphylactoid reaction 33.23 11.47 48 180542 6778 110401931
Hypoperfusion 33.21 11.47 33 180557 3148 110405561
Encephalitis 33.18 11.47 86 180504 18753 110389956
Product use issue 33.11 11.47 337 180253 311358 110097351
Intentional self-injury 33.03 11.47 10 180580 37419 110371290
Exfoliative rash 32.93 11.47 39 180551 4535 110404174
Cerebrovascular accident 32.91 11.47 168 180422 181116 110227593
SJS-TEN overlap 32.69 11.47 26 180564 1848 110406861
Differentiation syndrome 32.56 11.47 32 180558 3012 110405697
Cryptococcosis 32.54 11.47 39 180551 4592 110404117
Metabolic encephalopathy 32.54 11.47 62 180528 10998 110397711
Joint dislocation 32.30 11.47 8 180582 34182 110374527
Hypervolaemia 32.24 11.47 163 180427 49297 110359412
Malignant neoplasm progression 32.13 11.47 161 180429 174406 110234303
Circulatory collapse 31.85 11.47 147 180443 42846 110365863
Haemorrhagic pneumonia 31.81 11.47 12 180578 184 110408525
Meningitis fungal 31.78 11.47 14 180576 325 110408384
Retinal vascular occlusion 31.76 11.47 17 180573 611 110408098
Skin test positive 31.67 11.47 23 180567 1426 110407283
Neuropathy peripheral 31.50 11.47 168 180422 179109 110229600
Drug tolerance decreased 31.30 11.47 4 180586 27536 110381173
Corynebacterium infection 31.21 11.47 26 180564 1974 110406735
Drug trough level 31.21 11.47 9 180581 55 110408654
Respiratory gas exchange disorder 31.14 11.47 19 180571 879 110407830
Hyperammonaemia 30.98 11.47 69 180521 13663 110395046
Abdominal pain 30.95 11.47 621 179969 512368 109896341
Femur fracture 30.94 11.47 17 180573 44452 110364257
Peritonitis 30.77 11.47 120 180470 32487 110376222
Aortoenteric fistula 30.47 11.47 11 180579 148 110408561
Orthostatic hypotension 30.44 11.47 38 180552 66211 110342498
Overgrowth fungal 30.34 11.47 11 180579 150 110408559
Hypothyroidism 30.28 11.47 45 180545 72854 110335855
Clostridium colitis 30.28 11.47 32 180558 3283 110405426
Pulmonary trichosporonosis 30.16 11.47 9 180581 63 110408646
Chronic sinusitis 30.12 11.47 3 180587 25081 110383628
Cell death 30.08 11.47 42 180548 5749 110402960
General physical health deterioration 29.98 11.47 501 180089 424794 109983915
Palpitations 29.78 11.47 146 180444 159066 110249643
Joint injury 29.76 11.47 14 180576 39980 110368729
Impaired work ability 29.63 11.47 4 180586 26415 110382294
Clostridium bacteraemia 29.54 11.47 15 180575 483 110408226
Factor V inhibition 29.53 11.47 14 180576 387 110408322
Bronchial anastomosis complication 29.52 11.47 10 180580 110 110408599
Overdose 29.51 11.47 242 180348 233552 110175157
Mycobacterium fortuitum infection 29.48 11.47 15 180575 485 110408224
Weissella infection 29.34 11.47 7 180583 17 110408692
Muscle spasticity 29.24 11.47 11 180579 35904 110372805
Diplopia 29.17 11.47 16 180574 41878 110366831
Fibromuscular dysplasia 29.11 11.47 13 180577 312 110408397
Device issue 29.10 11.47 10 180580 34525 110374184
Enterocolitis haemorrhagic 29.03 11.47 28 180562 2576 110406133
Febrile bone marrow aplasia 29.00 11.47 78 180512 17387 110391322
Cardiac disorder 28.94 11.47 50 180540 76230 110332479
Injection site haemorrhage 28.83 11.47 9 180581 33019 110375690
Mesangioproliferative glomerulonephritis 28.52 11.47 12 180578 248 110408461
Bacterial endophthalmitis 28.48 11.47 13 180577 329 110408380
Gout 28.46 11.47 12 180578 36554 110372155
Leuconostoc infection 28.45 11.47 8 180582 44 110408665
Sopor 28.44 11.47 12 180578 36534 110372175
Aspergillus test positive 28.42 11.47 19 180571 1031 110407678
Dermatitis atopic 28.33 11.47 4 180586 25537 110383172
Nodule 28.29 11.47 9 180581 32622 110376087
Disseminated aspergillosis 28.28 11.47 27 180563 2453 110406256
Pseudopolyp 28.24 11.47 16 180574 644 110408065
Pleocytosis 28.13 11.47 23 180567 1701 110407008
Blood lactate dehydrogenase increased 28.13 11.47 145 180445 44189 110364520
Birdshot chorioretinopathy 28.08 11.47 9 180581 82 110408627
Peritoneal effluent leukocyte count increased 28.02 11.47 7 180583 22 110408687
Drug level decreased 28.00 11.47 80 180510 18468 110390241
Adenovirus infection 27.97 11.47 58 180532 10936 110397773
Endocarditis staphylococcal 27.93 11.47 19 180571 1061 110407648
Breast cancer 27.90 11.47 14 180576 38528 110370181
Continuous haemodiafiltration 27.82 11.47 24 180566 1911 110406798
Candida sepsis 27.79 11.47 29 180561 2932 110405777
Hyper IgE syndrome 27.78 11.47 16 180574 665 110408044
Mediastinitis 27.75 11.47 21 180569 1387 110407322
Product dose omission in error 27.75 11.47 3 180587 23509 110385200
Electrocardiogram QT prolonged 27.70 11.47 286 180304 108674 110300035
Bacterial infection 27.44 11.47 148 180442 45888 110362821
Aminoaciduria 27.30 11.47 13 180577 363 110408346
Hepatomegaly 27.27 11.47 87 180503 21327 110387382
Heart rate decreased 27.26 11.47 59 180531 82697 110326012
Intraocular pressure increased 27.23 11.47 57 180533 10819 110397890
Endocarditis bacterial 27.20 11.47 23 180567 1782 110406927
Cystitis 27.20 11.47 41 180549 65995 110342714
Pneumomediastinum 26.87 11.47 37 180553 4999 110403710
Cardiac failure congestive 26.80 11.47 141 180449 150859 110257850
Ear infection 26.77 11.47 38 180552 62694 110346015
Movement disorder 26.69 11.47 13 180577 36391 110372318
Acute hepatic failure 26.51 11.47 124 180466 36344 110372365
Pericarditis fungal 26.35 11.47 12 180578 302 110408407
Spinal stroke 26.33 11.47 8 180582 60 110408649
Colitis 26.21 11.47 269 180321 102054 110306655
Arthrofibrosis 26.17 11.47 9 180581 104 110408605
Vanishing bile duct syndrome 26.17 11.47 29 180561 3139 110405570
Skin necrosis 26.13 11.47 86 180504 21426 110387283
Oropharyngeal pain 25.91 11.47 123 180467 135153 110273556
Eating disorder 25.89 11.47 9 180581 30849 110377860
Gastritis fungal 25.78 11.47 12 180578 318 110408391
Parkinsonism 25.76 11.47 3 180587 22184 110386525
Vitamin K deficiency 25.73 11.47 17 180573 904 110407805
Pulmonary mucormycosis 25.71 11.47 24 180566 2119 110406590
Sneezing 25.70 11.47 10 180580 31974 110376735
Rash pruritic 25.69 11.47 259 180331 97810 110310899
Toxic shock syndrome staphylococcal 25.62 11.47 6 180584 13 110408696
Lung abscess 25.51 11.47 36 180554 4976 110403733
Chills 25.39 11.47 445 180145 190135 110218574
Sinus congestion 25.36 11.47 9 180581 30450 110378259
Visual acuity reduced 25.33 11.47 112 180478 32061 110376648
Bronchiectasis 25.32 11.47 14 180576 36479 110372230
Vascular purpura 25.26 11.47 31 180559 3740 110404969
Injection site rash 25.22 11.47 4 180586 23415 110385294
Platelet transfusion 25.16 11.47 27 180563 2819 110405890
Hip fracture 25.10 11.47 13 180577 35138 110373571
Skin haemorrhage 25.08 11.47 5 180585 24822 110383887
Periorbital oedema 25.04 11.47 53 180537 10139 110398570
Diabetes mellitus 25.02 11.47 81 180509 99300 110309409
Macular degeneration 24.97 11.47 3 180587 21656 110387053
Lung neoplasm malignant 24.94 11.47 12 180578 33830 110374879
Blastomycosis 24.77 11.47 18 180572 1117 110407592
Rectal haemorrhage 24.72 11.47 106 180484 119727 110288982
Presyncope 24.67 11.47 26 180564 48861 110359848
Poor quality product administered 24.62 11.47 34 180556 4607 110404102
Pyroglutamic acidosis 24.50 11.47 23 180567 2045 110406664
Hepatosplenomegaly 24.45 11.47 42 180548 6877 110401832
Jaundice 24.32 11.47 173 180417 59063 110349646
Productive cough 24.27 11.47 100 180490 114205 110294504
Lymphadenopathy 24.25 11.47 183 180407 63652 110345057
Respiratory acidosis 24.23 11.47 63 180527 13763 110394946
Cutaneous mucormycosis 24.18 11.47 15 180575 715 110407994
Product label confusion 24.13 11.47 4 180586 22673 110386036
Meningitis eosinophilic 23.98 11.47 6 180584 19 110408690
Product quality issue 23.92 11.47 57 180533 77242 110331467
Abscess neck 23.91 11.47 19 180571 1349 110407360
Candida endophthalmitis 23.89 11.47 10 180580 204 110408505
Cryptococcal meningoencephalitis 23.87 11.47 12 180578 378 110408331
Back disorder 23.87 11.47 3 180587 20919 110387790
Epidermolysis bullosa 23.84 11.47 12 180578 379 110408330
Distributive shock 23.76 11.47 38 180552 5866 110402843
Glomerular filtration rate decreased 23.71 11.47 102 180488 28854 110379855
Cutaneous T-cell lymphoma stage I 23.62 11.47 9 180581 142 110408567
Necrotising colitis 23.59 11.47 21 180569 1744 110406965
Infusion site necrosis 23.54 11.47 8 180582 89 110408620
Oedema peripheral 23.54 11.47 386 180204 328274 110080435
Pneumonia bacterial 23.45 11.47 95 180495 26166 110382543
Procalcitonin abnormal 23.33 11.47 12 180578 397 110408312
Angiopathy 23.33 11.47 47 180543 8683 110400026
Allergy test positive 23.31 11.47 16 180574 907 110407802
Dysuria 23.29 11.47 39 180551 60192 110348517
Adverse drug reaction 23.26 11.47 91 180499 105468 110303241
Immunosuppressant drug level increased 23.25 11.47 56 180534 11668 110397041
Acute graft versus host disease in skin 23.16 11.47 53 180537 10687 110398022
Oedema 23.13 11.47 225 180365 209751 110198958
Gastroenteritis viral 23.12 11.47 11 180579 31215 110377494
Cardio-respiratory arrest 23.10 11.47 290 180300 115546 110293163
Pneumonia pseudomonal 23.07 11.47 43 180547 7503 110401206
Hypopyon 23.05 11.47 19 180571 1421 110407288
Arthritis bacterial 22.89 11.47 53 180537 10767 110397942
Paraspinal abscess 22.87 11.47 12 180578 414 110408295
Central nervous system injury 22.85 11.47 9 180581 156 110408553
Dehydration 22.85 11.47 320 180270 279191 110129518
Pyelonephritis fungal 22.84 11.47 11 180579 315 110408394
Respiratory tract infection 22.82 11.47 52 180538 71565 110337144
Injection site mass 22.78 11.47 6 180584 24607 110384102
Sedation 22.69 11.47 50 180540 69633 110339076
Fungal test positive 22.64 11.47 17 180573 1110 110407599
Limb injury 22.62 11.47 17 180573 37619 110371090
Septic pulmonary embolism 22.44 11.47 11 180579 328 110408381
Acute myeloid leukaemia 22.37 11.47 122 180468 37988 110370721
Thrombotic thrombocytopenic purpura 22.34 11.47 41 180549 7070 110401639
Exposure to allergen 22.31 11.47 13 180577 552 110408157
Throat irritation 22.30 11.47 33 180557 53519 110355190
Herpes zoster 22.28 11.47 96 180494 108283 110300426
Hyperhidrosis 22.23 11.47 197 180393 187101 110221608
Mood swings 22.21 11.47 5 180585 22807 110385902
Abdominal pain lower 22.20 11.47 17 180573 37266 110371443
Bacterial pericarditis 22.14 11.47 8 180582 108 110408601
Blood creatine phosphokinase increased 22.12 11.47 199 180391 72878 110335831
Hyperaemia 22.08 11.47 29 180561 3744 110404965
Brain death 22.05 11.47 39 180551 6534 110402175
Product prescribing error 21.99 11.47 31 180559 51300 110357409
Urine output decreased 21.98 11.47 77 180513 19799 110388910
Intensive care unit acquired weakness 21.95 11.47 23 180567 2336 110406373
Human ehrlichiosis 21.95 11.47 14 180576 701 110408008
Carpal tunnel syndrome 21.93 11.47 5 180585 22605 110386104
Ulcer haemorrhage 21.87 11.47 5 180585 22566 110386143
Inspiratory capacity decreased 21.86 11.47 24 180566 2571 110406138
Intra-abdominal fluid collection 21.84 11.47 29 180561 3785 110404924
Avian influenza 21.81 11.47 8 180582 113 110408596
Walking aid user 21.59 11.47 7 180583 25068 110383641
Head injury 21.57 11.47 23 180567 42994 110365715
Lactic acidosis 21.44 11.47 239 180351 92572 110316137
Splenic injury 21.41 11.47 10 180580 267 110408442
Glycosylated haemoglobin increased 21.41 11.47 6 180584 23613 110385096
Hypogonadism 21.40 11.47 21 180569 1973 110406736
Proteus test positive 21.37 11.47 14 180576 734 110407975
Device related bacteraemia 21.32 11.47 17 180573 1213 110407496
Clostridial sepsis 21.30 11.47 16 180574 1045 110407664
Musculoskeletal discomfort 21.30 11.47 6 180584 23532 110385177
Cerebral cyst 21.20 11.47 12 180578 482 110408227
Nephritis allergic 21.06 11.47 16 180574 1063 110407646
Neuralgia 21.05 11.47 29 180561 48449 110360260
Tooth disorder 20.94 11.47 11 180579 29498 110379211
Cardiovascular somatic symptom disorder 20.90 11.47 6 180584 36 110408673
Acinetobacter test positive 20.88 11.47 10 180580 283 110408426
Bladder cancer 20.68 11.47 4 180586 20288 110388421
Abscess limb 20.66 11.47 44 180546 8453 110400256
Foot fracture 20.51 11.47 8 180582 25538 110383171
White blood cell count increased 20.42 11.47 245 180345 96597 110312112
Lip oedema 20.41 11.47 41 180549 7559 110401150
Hepatitis 20.40 11.47 231 180359 89823 110318886
Erectile dysfunction 20.37 11.47 3 180587 18553 110390156
Graft versus host disease in skin 20.37 11.47 43 180547 8211 110400498
Encephalomalacia 20.33 11.47 18 180572 1484 110407225
Metastases to central nervous system 20.31 11.47 6 180584 22811 110385898
Botulism 20.27 11.47 12 180578 525 110408184
Panic attack 20.23 11.47 11 180579 28929 110379780
Stenotrophomonas test positive 20.19 11.47 11 180579 410 110408299
Bone pain 20.18 11.47 48 180542 65085 110343624
Upper airway necrosis 20.11 11.47 6 180584 42 110408667
Osteomyelitis fungal 20.09 11.47 11 180579 414 110408295
Central nervous system infection 20.02 11.47 19 180571 1713 110406996
Abortion spontaneous 19.95 11.47 16 180574 34266 110374443
Janeway lesion 19.95 11.47 5 180585 16 110408693
Endometrial disorder 19.89 11.47 13 180577 679 110408030
Ureaplasma infection 19.88 11.47 18 180572 1528 110407181
Hyperpyrexia 19.87 11.47 42 180548 8027 110400682
Complications of transplanted kidney 19.81 11.47 40 180550 7402 110401307
Citrobacter infection 19.80 11.47 17 180573 1345 110407364
Glomerulonephritis membranoproliferative 19.75 11.47 14 180576 836 110407873
Blood test abnormal 19.74 11.47 11 180579 28543 110380166
Loss of consciousness 19.71 11.47 215 180375 196091 110212618
Neoplasm progression 19.70 11.47 48 180542 64547 110344162
Second primary malignancy 19.65 11.47 3 180587 18065 110390644
Neoplasm malignant 19.60 11.47 19 180571 37124 110371585
Nephrolithiasis 19.57 11.47 50 180540 66162 110342547
Toothache 19.57 11.47 7 180583 23568 110385141
Meningitis staphylococcal 19.56 11.47 9 180581 232 110408477
Peritonitis bacterial 19.50 11.47 49 180541 10484 110398225
Urinary tract infection pseudomonal 19.50 11.47 21 180569 2201 110406508
Minimum inhibitory concentration increased 19.44 11.47 4 180586 3 110408706
Deafness bilateral 19.38 11.47 23 180567 2681 110406028
Abscess fungal 19.37 11.47 11 180579 445 110408264
Needle issue 19.32 11.47 3 180587 17837 110390872
Restless legs syndrome 19.30 11.47 8 180582 24618 110384091
Acute myeloid leukaemia recurrent 19.23 11.47 32 180558 5107 110403602
Splenomegaly 19.07 11.47 85 180505 24413 110384296
Infectious pleural effusion 19.03 11.47 31 180559 4860 110403849
Acute graft versus host disease 18.90 11.47 55 180535 12826 110395883
Uterine fistula 18.89 11.47 5 180585 21 110408688
Disseminated strongyloidiasis 18.88 11.47 12 180578 597 110408112
Renal disorder 18.88 11.47 142 180448 49337 110359372
Polyarthritis 18.78 11.47 4 180586 18959 110389750
Streptococcal bacteraemia 18.72 11.47 30 180560 4639 110404070
Injection site warmth 18.68 11.47 3 180587 17402 110391307
Red blood cell schistocytes present 18.61 11.47 13 180577 758 110407951
Wrong rate 18.60 11.47 8 180582 175 110408534
Subcutaneous emphysema 18.55 11.47 22 180568 2562 110406147
Urinary tract infection fungal 18.49 11.47 16 180574 1279 110407430
Urinary tract infection 18.47 11.47 399 180191 325883 110082826
Serum sickness-like reaction 18.35 11.47 13 180577 775 110407934
Tumour lysis syndrome 18.34 11.47 99 180491 30702 110378007
Mood altered 18.34 11.47 6 180584 21369 110387340
Affect lability 18.32 11.47 4 180586 18633 110390076
Atrial fibrillation 18.31 11.47 498 180092 229144 110179565
Sinus tachycardia 18.30 11.47 130 180460 44363 110364346
Metastases to muscle 18.30 11.47 10 180580 375 110408334
Toxic shock syndrome 18.19 11.47 17 180573 1503 110407206
Respiratory tract infection fungal 18.19 11.47 16 180574 1308 110407401
Uveitis 18.18 11.47 77 180513 21633 110387076
Delusion 18.16 11.47 8 180582 23747 110384962
Progressive multifocal leukoencephalopathy 18.16 11.47 9 180581 24947 110383762
Nervousness 18.15 11.47 20 180570 36831 110371878
Gastrointestinal haemorrhage 18.11 11.47 375 180215 165143 110243566
Urinary retention 18.10 11.47 56 180534 69627 110339082
Nocturia 18.07 11.47 3 180587 16987 110391722
Platelet dysfunction 18.05 11.47 11 180579 508 110408201
Thyroid disorder 18.04 11.47 3 180587 16966 110391743
Gingivitis ulcerative 18.03 11.47 11 180579 509 110408200
Wound dehiscence 17.96 11.47 40 180550 7922 110400787
Ascites 17.93 11.47 231 180359 92577 110316132
Cellulitis 17.78 11.47 297 180293 125719 110282990
Hypersomnia 17.75 11.47 12 180578 28049 110380660
Disseminated sporotrichosis 17.71 11.47 6 180584 66 110408643
Activated partial thromboplastin time prolonged 17.71 11.47 78 180512 22290 110386419
Therapy interrupted 17.70 11.47 34 180556 49788 110358921
Gastric disorder 17.68 11.47 17 180573 33340 110375369
Pollakiuria 17.66 11.47 28 180562 44167 110364542
Vessel puncture site inflammation 17.64 11.47 4 180586 7 110408702
Hernia 17.59 11.47 5 180585 19495 110389214
Eosinophils urine present 17.55 11.47 6 180584 68 110408641
Chemical peritonitis 17.55 11.47 9 180581 296 110408413
Metastases to bone marrow 17.54 11.47 14 180576 1000 110407709
Product use in unapproved indication 17.54 11.47 896 179694 446481 109962228
Extradural abscess 17.46 11.47 19 180571 2015 110406694
Frequent bowel movements 17.41 11.47 59 180531 71331 110337378
Therapy naive 17.32 11.47 6 180584 71 110408638
Metastases to retroperitoneum 17.31 11.47 10 180580 418 110408291
Gastrointestinal oedema 17.25 11.47 24 180566 3274 110405435
Feeling cold 17.24 11.47 18 180572 33969 110374740
Skin maceration 17.22 11.47 8 180582 211 110408498
Malnutrition 17.15 11.47 89 180501 27190 110381519
Ileus 17.12 11.47 97 180493 30632 110378077
Hyperlipidaemia 17.06 11.47 20 180570 35828 110372881
Serratia bacteraemia 17.02 11.47 6 180584 75 110408634
Mycotic endophthalmitis 16.93 11.47 10 180580 436 110408273
Head discomfort 16.90 11.47 5 180585 18995 110389714
Puerperal pyrexia 16.88 11.47 5 180585 34 110408675
Masked fever 16.88 11.47 5 180585 34 110408675
Drug chemical incompatibility 16.85 11.47 7 180583 140 110408569
Cardiac valve abscess 16.85 11.47 7 180583 140 110408569
Interleukin-2 receptor increased 16.83 11.47 9 180581 323 110408386
Manipulation 16.81 11.47 6 180584 78 110408631
Fibrosis 16.80 11.47 38 180552 7604 110401105
Hypovolaemia 16.72 11.47 75 180515 21599 110387110
Unmasking of previously unidentified disease 16.72 11.47 22 180568 2846 110405863
Fixed eruption 16.71 11.47 27 180563 4205 110404504
Disease progression 16.66 11.47 519 180071 243515 110165194
Therapeutic response decreased 16.63 11.47 91 180499 96408 110312301
Ventricular tachycardia 16.60 11.47 139 180451 49870 110358839
Blood albumin decreased 16.55 11.47 89 180501 27563 110381146
Meningoencephalitis herpetic 16.50 11.47 20 180570 2382 110406327
Escherichia bacteraemia 16.48 11.47 45 180545 10119 110398590
Cavernous sinus thrombosis 16.42 11.47 10 180580 461 110408248
Pseudoendophthalmitis 16.40 11.47 6 180584 84 110408625
Liver transplant failure 16.28 11.47 7 180583 153 110408556
Haemangioma congenital 16.26 11.47 3 180587 0 110408709
Klebsiella test positive 16.21 11.47 20 180570 2426 110406283
Generalised onset non-motor seizure 16.21 11.47 6 180584 87 110408622
Dysstasia 16.14 11.47 18 180572 32968 110375741
Body temperature decreased 16.13 11.47 22 180568 36913 110371796
Ankylosing spondylitis 16.08 11.47 3 180587 15609 110393100
Hepatitis cholestatic 16.05 11.47 64 180526 17502 110391207
Disseminated coccidioidomycosis 16.03 11.47 8 180582 248 110408461
Corynebacterium sepsis 16.03 11.47 8 180582 248 110408461
Renal abscess 15.98 11.47 16 180574 1540 110407169
Bullous haemorrhagic dermatosis 15.98 11.47 9 180581 358 110408351
Herpes simplex test positive 15.94 11.47 11 180579 629 110408080
Hepatotoxicity 15.91 11.47 166 180424 63234 110345475
Lemierre syndrome 15.91 11.47 7 180583 162 110408547
Pasteurella infection 15.91 11.47 7 180583 162 110408547
Eye pruritus 15.91 11.47 18 180572 32757 110375952
Quadriparesis 15.89 11.47 28 180562 4679 110404030
Drug clearance decreased 15.87 11.47 26 180564 4096 110404613
Malignant melanoma 15.86 11.47 4 180586 16887 110391822
Device dislocation 15.84 11.47 17 180573 31687 110377022
Dementia 15.81 11.47 17 180573 31656 110377053
Therapeutic response shortened 15.77 11.47 15 180575 29568 110379141
Procedural pain 15.72 11.47 21 180569 35544 110373165
Renal tubular atrophy 15.72 11.47 19 180571 2257 110406452
Bacterial toxaemia 15.71 11.47 7 180583 167 110408542
Anxiety 15.70 11.47 436 180154 344642 110064067
Laboratory test interference 15.66 11.47 15 180575 1368 110407341
Palpable purpura 15.64 11.47 10 180580 503 110408206
Radiculopathy 15.61 11.47 6 180584 19330 110389379
Micturition urgency 15.59 11.47 6 180584 19314 110389395
Thrombophlebitis septic 15.56 11.47 10 180580 507 110408202
Periphlebitis 15.56 11.47 5 180585 46 110408663
Cerebral aspergillosis 15.55 11.47 19 180571 2283 110406426
Laryngeal stenosis 15.52 11.47 15 180575 1383 110407326
Bronchial obstruction 15.50 11.47 22 180568 3057 110405652
Metastases to bone 15.48 11.47 17 180573 31355 110377354
Periostosis 15.47 11.47 4 180586 15 110408694
Blood iron decreased 15.45 11.47 6 180584 19208 110389501
Drug tolerance 15.43 11.47 4 180586 16581 110392128
Rhinitis allergic 15.43 11.47 5 180585 17917 110390792
Lymphocyte morphology abnormal 15.43 11.47 13 180577 1002 110407707
Post procedural complication 15.42 11.47 85 180505 26573 110382136
Wound infection bacterial 15.40 11.47 13 180577 1005 110407704
Peripheral sensorimotor neuropathy 15.35 11.47 25 180565 3918 110404791
Brain oedema 15.29 11.47 95 180495 31003 110377706
Abdominal abscess 15.27 11.47 40 180550 8779 110399930
Spinal fracture 15.25 11.47 9 180581 22624 110386085
Poor quality sleep 15.24 11.47 14 180576 28063 110380646
Spinal stenosis 15.24 11.47 6 180584 19050 110389659
Balamuthia infection 15.23 11.47 6 180584 104 110408605
Shunt infection 15.22 11.47 8 180582 277 110408432
Livedo reticularis 15.14 11.47 30 180560 5476 110403233
Respiratory symptom 15.12 11.47 3 180587 14942 110393767
Septic encephalopathy 15.12 11.47 9 180581 398 110408311
Vestibular disorder 15.05 11.47 20 180570 2612 110406097
Capillary leak syndrome 15.04 11.47 28 180562 4880 110403829
Infective thrombosis 15.02 11.47 6 180584 108 110408601
Corneal opacity 14.99 11.47 14 180576 1237 110407472
Intentional dose omission 14.98 11.47 7 180583 20073 110388636
Pulmonary embolism 14.98 11.47 253 180337 214221 110194488
Eye allergy 14.95 11.47 13 180577 1046 110407663
Apathy 14.95 11.47 4 180586 16235 110392474
Hydrocephalus 14.94 11.47 44 180546 10331 110398378
Anti factor Xa activity decreased 14.89 11.47 4 180586 18 110408691
Blood creatine increased 14.85 11.47 47 180543 11474 110397235
Surgery 14.82 11.47 28 180562 41255 110367454
Azotaemia 14.74 11.47 43 180547 10042 110398667
Infective keratitis 14.73 11.47 6 180584 114 110408595
Bone density decreased 14.68 11.47 4 180586 16038 110392671
Ankle fracture 14.65 11.47 7 180583 19812 110388897
Pulmonary cavitation 14.64 11.47 18 180572 2176 110406533
Papule 14.61 11.47 43 180547 10090 110398619
Limbal swelling 14.54 11.47 4 180586 20 110408689
Pulmonary pneumatocele 14.54 11.47 4 180586 20 110408689
BK polyomavirus test positive 14.54 11.47 8 180582 304 110408405
HIV viraemia 14.54 11.47 6 180584 118 110408591
Toxic shock syndrome streptococcal 14.52 11.47 8 180582 305 110408404
Graft versus host disease in liver 14.51 11.47 19 180571 2446 110406263
Acute coronary syndrome 14.46 11.47 10 180580 23102 110385607
Abnormal behaviour 14.44 11.47 26 180564 39013 110369696
Transfusion-related acute lung injury 14.38 11.47 9 180581 436 110408273
Gastroenteritis staphylococcal 14.37 11.47 8 180582 311 110408398
Infusion site streaking 14.36 11.47 10 180580 580 110408129
Akathisia 14.34 11.47 5 180585 17108 110391601
Respiratory alkalosis 14.34 11.47 30 180560 5691 110403018
Hepatic steatosis 14.33 11.47 37 180553 48794 110359915
Obstructive airways disorder 14.30 11.47 34 180556 46115 110362594
Cytomegalovirus colitis 14.30 11.47 34 180556 7027 110401682
Nutritional condition abnormal 14.29 11.47 14 180576 1313 110407396
Immunodeficiency 14.24 11.47 26 180564 38812 110369897
Hepatic vein occlusion 14.24 11.47 8 180582 317 110408392
Tetanus 14.22 11.47 5 180585 62 110408647
Epidermal necrosis 14.20 11.47 21 180569 3029 110405680
Uterine necrosis 14.18 11.47 3 180587 3 110408706
Benign prostatic hyperplasia 14.17 11.47 6 180584 18228 110390481
Peripheral ischaemia 14.15 11.47 45 180545 11013 110397696
Legionella infection 14.04 11.47 12 180578 944 110407765
Middle insomnia 14.03 11.47 8 180582 20494 110388215
Flavobacterium infection 14.00 11.47 6 180584 130 110408579
Jaundice cholestatic 13.98 11.47 54 180536 14554 110394155
Electrolyte imbalance 13.98 11.47 106 180484 36922 110371787
Lacrimation increased 13.96 11.47 18 180572 30932 110377777
Blood beta-D-glucan increased 13.95 11.47 11 180579 772 110407937
Musculoskeletal disorder 13.93 11.47 10 180580 22654 110386055
Rotator cuff syndrome 13.92 11.47 5 180585 16789 110391920
Dystonia 13.85 11.47 13 180577 25792 110382917
Morganella infection 13.83 11.47 14 180576 1365 110407344
Sensory loss 13.81 11.47 9 180581 21448 110387261
Mast cell degranulation present 13.80 11.47 5 180585 68 110408641
Propofol infusion syndrome 13.78 11.47 19 180571 2570 110406139
Encephalitis Japanese B 13.74 11.47 5 180585 69 110408640
Intracranial infection 13.73 11.47 8 180582 340 110408369
Gas gangrene 13.73 11.47 8 180582 340 110408369
Bacillus infection 13.72 11.47 15 180575 1599 110407110
Large intestinal ulcer haemorrhage 13.70 11.47 8 180582 341 110408368
Acute febrile neutrophilic dermatosis 13.70 11.47 27 180563 4909 110403800
Infective corneal ulcer 13.66 11.47 4 180586 26 110408683
Ischaemic hepatitis 13.60 11.47 26 180564 4622 110404087
Urinary tract candidiasis 13.57 11.47 13 180577 1186 110407523
Limb discomfort 13.56 11.47 29 180561 40825 110367884
Excessive eye blinking 13.55 11.47 16 180574 1854 110406855
Holmes-Adie pupil 13.53 11.47 4 180586 27 110408682
Wrong product administered 13.48 11.47 44 180546 10916 110397793
Angina unstable 13.43 11.47 5 180585 16427 110392282
Bullous erysipelas 13.40 11.47 4 180586 28 110408681
Wernicke's encephalopathy 13.40 11.47 4 180586 28 110408681
Choking 13.40 11.47 4 180586 15106 110393603
Symptom masked 13.38 11.47 16 180574 1879 110406830
Urinary incontinence 13.37 11.47 38 180552 48549 110360160
Eye excision 13.29 11.47 5 180585 76 110408633
Intravascular haemolysis 13.29 11.47 12 180578 1015 110407694
Glomerulonephritis 13.28 11.47 26 180564 4704 110404005
Skin irritation 13.28 11.47 5 180585 16314 110392395
Implant site hypersensitivity 13.28 11.47 4 180586 29 110408680
Cystic fibrosis 13.28 11.47 26 180564 4705 110404004
Psychological trauma 13.28 11.47 15 180575 1658 110407051
Metastases to spleen 13.23 11.47 11 180579 833 110407876
Hyperthyroidism 13.22 11.47 17 180573 29244 110379465
Haemoperitoneum 13.21 11.47 28 180562 5360 110403349
Vulvovaginitis 13.21 11.47 8 180582 365 110408344
Rectal perforation 13.19 11.47 12 180578 1025 110407684
Endocarditis enterococcal 13.13 11.47 8 180582 369 110408340
Eczema 13.11 11.47 67 180523 72226 110336483
Epstein-Barr virus infection 13.10 11.47 63 180527 18675 110390034
Feeling hot 13.05 11.47 91 180499 91015 110317694
Tremor 13.03 11.47 242 180348 201990 110206719
Mania 13.01 11.47 9 180581 20787 110387922
Large intestine infection 12.99 11.47 25 180565 4467 110404242
Escherichia test positive 12.99 11.47 22 180568 3562 110405147
Restrictive cardiomyopathy 12.96 11.47 12 180578 1049 110407660
Sputum culture positive 12.95 11.47 23 180567 3866 110404843
Protein C decreased 12.95 11.47 5 180585 82 110408627
Cytokine storm 12.93 11.47 14 180576 1476 110407233
Skin laceration 12.92 11.47 22 180568 33731 110374978
Endotracheal intubation 12.89 11.47 30 180560 6114 110402595
Infective aortitis 12.84 11.47 5 180585 84 110408625
Therapeutic response unexpected 12.81 11.47 12 180578 23831 110384878
Klebsiella bacteraemia 12.76 11.47 26 180564 4843 110403866
Blood pressure diastolic abnormal 12.73 11.47 14 180576 25801 110382908
Fracture 12.72 11.47 13 180577 24775 110383934
Dizziness postural 12.71 11.47 4 180586 14605 110394104
Transplant rejection 12.68 11.47 76 180514 24491 110384218
Pulmonary oedema 12.68 11.47 233 180357 100426 110308283
Pseudomonal sepsis 12.68 11.47 38 180552 9008 110399701
Diabetic gastroparesis 12.68 11.47 8 180582 393 110408316
Parosmia 12.61 11.47 3 180587 13177 110395532
Seronegative arthritis 12.61 11.47 3 180587 13174 110395535
Coronary artery occlusion 12.56 11.47 5 180585 15767 110392942
Haemostasis 12.55 11.47 9 180581 547 110408162
Lymphocytic infiltration 12.53 11.47 16 180574 2009 110406700
Aortic pseudoaneurysm 12.52 11.47 5 180585 90 110408619
Epilepsy 12.51 11.47 104 180486 100105 110308604
Herpes simplex 12.50 11.47 55 180535 15709 110393000
Meningitis aseptic 12.48 11.47 40 180550 9830 110398879
Epstein-Barr virus test positive 12.47 11.47 13 180577 1313 110407396
Product administered to patient of inappropriate age 12.46 11.47 35 180555 8001 110400708
Anal skin tags 12.42 11.47 9 180581 556 110408153
Red cell distribution width abnormal 12.42 11.47 7 180583 279 110408430
Macule 12.42 11.47 22 180568 3691 110405018
Incorrect route of product administration 12.41 11.47 58 180532 64003 110344706
Bacteroides test positive 12.33 11.47 4 180586 38 110408671
Necrotising fasciitis fungal 12.33 11.47 4 180586 38 110408671
Gastrointestinal mucormycosis 12.33 11.47 10 180580 731 110407978
Wrong patient received product 12.31 11.47 31 180559 6643 110402066
Osmotic demyelination syndrome 12.30 11.47 16 180574 2047 110406662
Neutrophilia 12.29 11.47 41 180549 10288 110398421
Blood fibrinogen increased 12.27 11.47 16 180574 2052 110406657
Pneumococcal infection 12.26 11.47 15 180575 1804 110406905
Diabetic ketoacidosis 12.25 11.47 32 180558 42026 110366683
Promyelocyte count increased 12.24 11.47 4 180586 39 110408670
Hepato-lenticular degeneration 12.24 11.47 4 180586 39 110408670
Splenic infarction 12.23 11.47 24 180566 4350 110404359
Abscess bacterial 12.23 11.47 11 180579 926 110407783
Electrocardiogram repolarisation abnormality 12.23 11.47 17 180573 2318 110406391
Disability 12.22 11.47 19 180571 30204 110378505
Bone disorder 12.19 11.47 10 180580 21182 110387527
Exposure during pregnancy 12.18 11.47 196 180394 167228 110241481
Transfusion reaction 12.16 11.47 16 180574 2069 110406640
Dehiscence 12.13 11.47 10 180580 748 110407961
Coordination abnormal 12.09 11.47 14 180576 25214 110383495
Disturbance in attention 12.08 11.47 56 180534 61939 110346770
Treatment failure 12.06 11.47 561 180029 276673 110132036
Dental caries 12.04 11.47 3 180587 12770 110395939
Postoperative renal failure 12.02 11.47 6 180584 186 110408523
Keratitis fungal 12.02 11.47 8 180582 431 110408278
Irritability 12.01 11.47 39 180551 47770 110360939
Facial pain 11.99 11.47 5 180585 15334 110393375
Bandaemia 11.98 11.47 8 180582 433 110408276
Pneumonia toxoplasmal 11.98 11.47 4 180586 42 110408667
Traumatic haemothorax 11.97 11.47 10 180580 762 110407947
Arteriosclerosis coronary artery 11.97 11.47 14 180576 25104 110383605
Blood pressure diastolic increased 11.95 11.47 8 180582 18799 110389910
Paraesthesia oral 11.94 11.47 23 180567 33648 110375061
Vaginal haemorrhage 11.92 11.47 14 180576 25060 110383649
Product compounding quality issue 11.89 11.47 4 180586 43 110408666
Anticonvulsant drug level decreased 11.86 11.47 16 180574 2120 110406589
Culture urine positive 11.85 11.47 25 180565 4771 110403938
Metastases to liver 11.84 11.47 25 180565 35361 110373348
Altered state of consciousness 11.80 11.47 145 180445 57481 110351228
Ovarian cyst 11.80 11.47 4 180586 13926 110394783
Pulmonary resection 11.79 11.47 6 180584 194 110408515
Pseudomonas aeruginosa meningitis 11.77 11.47 5 180585 106 110408603
Intestinal ischaemia 11.75 11.47 55 180535 16124 110392585
Central nervous system vasculitis 11.74 11.47 14 180576 1640 110407069
Angina pectoris 11.72 11.47 57 180533 62238 110346471
Pancreatic pseudocyst 11.71 11.47 14 180576 1644 110407065
Iron deficiency anaemia 11.69 11.47 21 180569 31538 110377171
Acid-base balance disorder mixed 11.68 11.47 5 180585 108 110408601
Intraventricular haemorrhage 11.68 11.47 27 180563 5480 110403229
Prostatic specific antigen increased 11.68 11.47 3 180587 12508 110396201
Cardiovascular insufficiency 11.67 11.47 20 180570 3268 110405441
Blast cell proliferation 11.65 11.47 3 180587 11 110408698
Ependymitis 11.65 11.47 3 180587 11 110408698
Alpha haemolytic streptococcal infection 11.65 11.47 21 180569 3572 110405137
Ageusia 11.64 11.47 9 180581 19636 110389073
Burkholderia test positive 11.63 11.47 9 180581 615 110408094
Anosmia 11.62 11.47 3 180587 12469 110396240
Thirst 11.58 11.47 11 180579 21696 110387013
Abdominal compartment syndrome 11.57 11.47 15 180575 1912 110406797
Deafness 11.55 11.47 79 180511 26630 110382079
Hyperamylasaemia 11.53 11.47 12 180578 1209 110407500
Gastrointestinal wall thickening 11.52 11.47 21 180569 3602 110405107
ADAMTS13 activity decreased 11.51 11.47 7 180583 322 110408387
Pulmonary alveolar haemorrhage 11.49 11.47 64 180526 20086 110388623
Hepatic cytolysis 11.48 11.47 139 180451 54914 110353795

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 73.31 27.03 62 520 1571 111800
Foetal exposure during pregnancy 54.47 27.03 10 572 15768 97603
Systemic candida 32.12 27.03 11 571 33 113338
Nephropathy toxic 31.78 27.03 8 574 3 113368
Renal impairment 27.15 27.03 11 571 59 113312

Pharmacologic Action:

SourceCodeDescription
ATC A07AA09 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Glycopeptide antibacterials
ATC S01AA28 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA CS M0009481 Glycopeptides
FDA EPC N0000175491 Glycopeptide Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:76969 bacterial metabolite

Related Drugs by ATC class:

A07AA Antibiotics 12 drugs
amphotericin BcolistinfidaxomicinkanamycinnatamycinneomycinnystatinparomomycinPolymyxin Brifamycinrifaximinstreptomycin
J01XA Glycopeptide antibacterials 4 drugs
dalbavancinoritavancinteicoplanintelavancin
S01AA Antibiotics 27 drugs
amikacinampicillinazidamfenicolazithromycinbacitracinbenzylpenicillincefmenoximecefuroximechloramphenicolchlortetracyclinedibekacindihydrostreptomycin show all 27 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal pneumonia indication 22754005
Staphylococcal enterocolitis indication 32527003
Lower respiratory tract infection indication 50417007
Staphylococcal infectious disease indication 56038003
Staphylococcal endocarditis indication 73028002
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Sepsis of the newborn indication 206376005
Neonatal pneumonia indication 233619008
Infective endocarditis indication 233850007
Bacterial endocarditis indication 301183007
Infectious disorder of joint indication 363162000
Pseudomembranous enterocolitis indication 397683000
Infection due to Staphylococcus aureus indication 406602003
Osteomyelitis due to Staphylococcus aureus indication 428783003
Streptococcal Endocarditis indication
Prosthetic Heart Valve Endocarditis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Neonatal Group B Streptococcal Septicemia indication
Staphylococcal Prosthetic Heart Valve Endocarditis indication
Diphtheroid Prosthetic Heart Valve Endocarditis indication
Clostridium difficile diarrhea indication
Streptococcal meningitis off-label use 4510004 DOID:11574
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Staphylococcal meningitis off-label use 12166008
Diphtheritic myocarditis off-label use 26117009
Erysipelas off-label use 44653001 DOID:11330
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Neonatal meningitis off-label use 276674008
Anthrax off-label use 409498004 DOID:7427
Abscess of brain off-label use 441806004
Perioperative Infection off-label use
Listeria Monocytogenes Septicemia off-label use
Prevention of Perioperative Infection off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Acute nephropathy contraindication 58574008
Kidney disease contraindication 90708001 DOID:557
Hearing disorder contraindication 128540005
Vancomycin poisoning contraindication 291518001
Neutropenic disorder contraindication 303011007 DOID:1227




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.55 acidic
pKa2 7.69 acidic
pKa3 10.72 acidic
pKa4 11.48 acidic
pKa5 11.49 acidic
pKa6 12.17 acidic
pKa7 12.41 acidic
pKa8 12.78 acidic
pKa9 13.04 acidic
pKa10 13.2 acidic
pKa11 13.59 acidic
pKa12 8.96 Basic
pKa13 8.3 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 1.25GM BASE/250ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.25GM BASE/250ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.25GM BASE/250ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.75GM BASE/350ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.75GM BASE/350ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.75GM BASE/350ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 750MG BASE/150ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 750MG BASE/150ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 750MG BASE/150ML (EQ 5MG BASE/ML) TYZAVAN HIKMA N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
5GM/100ML (50MG/ML) VANCOMYCIN HIKMA N213895 Aug. 26, 2021 DISCN SOLUTION INTRAVENOUS, ORAL 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
5GM/100ML (50MG/ML) VANCOMYCIN HIKMA N213895 Aug. 26, 2021 DISCN SOLUTION INTRAVENOUS, ORAL 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
5GM/100ML (50MG/ML) VANCOMYCIN HIKMA N213895 Aug. 26, 2021 DISCN SOLUTION INTRAVENOUS, ORAL 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 7.30 CHEMBL
D-alanyl-D-alanine dipeptidase Enzyme Ki 4.21 CHEMBL
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Enzyme IC50 5 CHEMBL

External reference:

IDSource
4019967 VUID
N0000148052 NUI
D00212 KEGG_DRUG
1404-93-9 SECONDARY_CAS_RN
4017454 VANDF
4019967 VANDF
C0042313 UMLSCUI
CHEBI:28001 CHEBI
CHEMBL262777 ChEMBL_ID
CHEMBL1200628 ChEMBL_ID
D014640 MESH_DESCRIPTOR_UI
DB00512 DRUGBANK_ID
10932 IUPHAR_LIGAND_ID
680 INN_ID
6Q205EH1VU UNII
14969 PUBCHEM_CID
11124 RXNORM
253520 MMSL
30222 MMSL
3125 MMSL
38014 MMSL
41853 MMSL
4652 MMSL
5664 MMSL
7306 MMSL
d00125 MMSL
002791 NDDF
004866 NDDF
372735009 SNOMEDCT_US
42082003 SNOMEDCT_US
66509009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-1032 CAPSULE 125 mg ORAL ANDA 25 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-1033 CAPSULE 250 mg ORAL ANDA 25 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9152 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.25 g INTRAVENOUS ANDA 29 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9153 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.50 g INTRAVENOUS ANDA 29 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9161 INJECTION, POWDER, FOR SOLUTION 513 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9162 INJECTION, POWDER, FOR SOLUTION 1025 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9163 INJECTION, POWDER, FOR SOLUTION 5.13 g INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9164 INJECTION, POWDER, FOR SOLUTION 10.25 g INTRAVENOUS NDA 30 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9355 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 750 mg INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9356 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9357 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9358 INJECTION, POWDER, FOR SOLUTION 5 g INTRAVENOUS ANDA 22 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9359 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 22 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9466 INJECTION, SOLUTION 1.25 g INTRAVENOUS NDA 31 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9467 INJECTION, SOLUTION 1.75 g INTRAVENOUS NDA 31 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9468 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 31 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9469 INJECTION, SOLUTION 1.50 g INTRAVENOUS NDA 31 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9470 INJECTION, SOLUTION 2 g INTRAVENOUS NDA 31 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9471 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 31 sections
TYZAVAN HUMAN PRESCRIPTION DRUG LABEL 1 0143-9472 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 31 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9473 INJECTION, POWDER, FOR SOLUTION 769 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9474 INJECTION, POWDER, FOR SOLUTION 1280 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9475 INJECTION, POWDER, FOR SOLUTION 1540 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0122 INJECTION, SOLUTION 1.25 g INTRAVITREAL NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0124 INJECTION, SOLUTION 1.50 g INTRAVITREAL NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3551 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3552 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3580 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3581 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3582 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 30 sections