vancomycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2807 1404-90-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vancomycin
  • diatracin
  • vancocin
  • vancocine
  • vancoled
  • vancomycin hydrochloride
  • vancomycin HCl
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
  • Molecular weight: 1449.27
  • Formula: C66H75Cl2N9O24
  • CLOGP: -2.23
  • LIPINSKI: 3
  • HAC: 33
  • HDO: 19
  • TPSA: 530.49
  • ALOGS: -3.81
  • ROTB: 13

Drug dosage:

DoseUnitRoute
2 g O
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 79 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 22.44 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.54 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 1978.59 11.72 913 74936 32923 63380250
Acute kidney injury 1529.22 11.72 1720 74129 261695 63151478
Linear IgA disease 746.88 11.72 199 75650 1252 63411921
Multiple organ dysfunction syndrome 700.25 11.72 564 75285 56188 63356985
Septic shock 540.59 11.72 522 75327 66107 63347066
Renal tubular necrosis 528.24 11.72 266 75583 11612 63401561
Eosinophilia 514.11 11.72 327 75522 22429 63390744
Acute generalised exanthematous pustulosis 454.18 11.72 235 75614 10864 63402309
Toxic epidermal necrolysis 423.48 11.72 302 75547 25032 63388141
Nephropathy toxic 400.26 11.72 205 75644 9274 63403899
Fatigue 393.54 11.72 294 75555 887734 62525439
Clostridium difficile infection 368.02 11.72 297 75552 29625 63383548
Sepsis 345.82 11.72 640 75209 152483 63260690
Drug hypersensitivity 319.05 11.72 953 74896 309734 63103439
Retinal vasculitis 306.92 11.72 91 75758 883 63412290
Pathogen resistance 304.29 11.72 150 75699 6248 63406925
Pyrexia 296.73 11.72 1228 74621 469250 62943923
Arthralgia 277.92 11.72 169 75680 569541 62843632
Renal failure 259.52 11.72 487 75362 117165 63296008
Antibiotic level above therapeutic 254.20 11.72 64 75785 310 63412863
Arthropathy 248.16 11.72 7 75842 234785 63178388
Drug level increased 236.71 11.72 205 75644 22531 63390642
Rash maculo-papular 232.70 11.72 236 75613 31660 63381513
Clostridium difficile colitis 231.61 11.72 194 75655 20375 63392798
Alopecia 229.71 11.72 60 75789 337476 63075697
Joint swelling 229.27 11.72 55 75794 327611 63085562
Contraindicated product administered 224.59 11.72 8 75841 217640 63195533
Drug resistance 209.41 11.72 192 75657 22741 63390432
Abdominal discomfort 209.09 11.72 62 75787 320823 63092350
Respiratory failure 205.41 11.72 406 75443 101452 63311721
Headache 203.76 11.72 276 75573 632965 62780208
Thrombocytopenia 193.54 11.72 503 75346 150654 63262519
Enterococcal infection 192.83 11.72 119 75730 7729 63405444
Glossodynia 186.55 11.72 6 75843 178870 63234303
Synovitis 185.71 11.72 9 75840 186909 63226264
Tubulointerstitial nephritis 184.39 11.72 168 75681 19735 63393438
Pain 181.10 11.72 385 75464 740243 62672930
Rheumatoid arthritis 176.69 11.72 43 75806 253776 63159397
Encephalopathy 176.27 11.72 224 75625 38396 63374777
Toxic skin eruption 175.79 11.72 136 75713 12749 63400424
Haemophagocytic lymphohistiocytosis 171.37 11.72 124 75725 10503 63402670
Blood creatinine increased 167.35 11.72 342 75507 87502 63325671
Renal impairment 167.15 11.72 343 75506 88012 63325161
Stevens-Johnson syndrome 166.48 11.72 176 75673 24774 63388399
Pancytopenia 165.65 11.72 361 75488 96572 63316601
Dizziness 164.36 11.72 163 75686 429762 62983411
Staphylococcal infection 161.60 11.72 222 75627 41034 63372139
Systemic lupus erythematosus 158.49 11.72 29 75820 208889 63204284
Renal injury 145.10 11.72 107 75742 9332 63403841
Therapeutic product effect decreased 141.91 11.72 29 75820 193158 63220015
Bacteraemia 140.67 11.72 136 75713 17212 63395961
Disseminated intravascular coagulation 137.18 11.72 140 75709 18911 63394262
Febrile neutropenia 136.26 11.72 379 75470 118070 63295103
Drug intolerance 133.58 11.72 104 75745 308557 63104616
Fall 133.11 11.72 164 75685 392170 63021003
Swelling 130.71 11.72 84 75765 275294 63137879
Pseudomembranous colitis 130.48 11.72 67 75782 3045 63410128
Shock 129.73 11.72 150 75699 23313 63389860
Product dose omission issue 126.30 11.72 61 75788 234252 63178921
Peripheral swelling 125.02 11.72 82 75767 265860 63147313
Drug ineffective for unapproved indication 119.63 11.72 174 75675 33889 63379284
Nasopharyngitis 118.69 11.72 79 75770 254178 63158995
Cholestasis 117.69 11.72 160 75689 29274 63383899
Systemic candida 116.55 11.72 63 75786 3182 63409991
Pain in extremity 115.11 11.72 136 75713 331350 63081823
Musculoskeletal stiffness 114.21 11.72 39 75810 184579 63228594
Hypotension 113.31 11.72 632 75217 271972 63141201
Device related infection 112.01 11.72 139 75710 23253 63389920
Stenotrophomonas infection 109.91 11.72 52 75797 1975 63411198
Klebsiella infection 107.34 11.72 86 75763 8480 63404693
Insomnia 107.21 11.72 62 75787 215190 63197983
Bacterial disease carrier 107.03 11.72 45 75804 1286 63411887
Rash morbilliform 106.89 11.72 60 75789 3265 63409908
Cytokine release syndrome 104.53 11.72 106 75743 14208 63398965
Wound 103.59 11.72 33 75816 163230 63249943
Weight increased 102.85 11.72 96 75753 260696 63152477
Dermatitis exfoliative 102.68 11.72 70 75779 5389 63407784
Haemorrhagic vasculitis 101.30 11.72 23 75826 64 63413109
Agranulocytosis 101.05 11.72 137 75712 24997 63388176
Pericarditis 100.32 11.72 18 75831 131561 63281612
Cardiac arrest 99.46 11.72 289 75560 92256 63320917
Drug level above therapeutic 98.51 11.72 65 75784 4740 63408433
Malaise 97.36 11.72 221 75628 415733 62997440
Acute respiratory distress syndrome 97.24 11.72 130 75719 23404 63389769
Staphylococcal bacteraemia 97.17 11.72 68 75781 5462 63407711
Bronchopulmonary aspergillosis 96.27 11.72 81 75768 8554 63404619
Leukocytosis 93.28 11.72 134 75715 25801 63387372
Superinfection 91.93 11.72 50 75799 2557 63410616
Dysbiosis 91.25 11.72 36 75813 870 63412303
Sinusitis 91.06 11.72 82 75767 226571 63186602
Discomfort 91.03 11.72 43 75806 167331 63245842
Anaphylactic reaction 90.75 11.72 226 75623 65874 63347299
Hypoxia 89.10 11.72 211 75638 59581 63353592
Neurotoxicity 87.91 11.72 105 75744 16885 63396288
Nausea 86.80 11.72 632 75217 853839 62559334
Psoriatic arthropathy 85.99 11.72 6 75843 91514 63321659
Leukopenia 85.59 11.72 244 75605 77046 63336127
Fungaemia 84.49 11.72 46 75803 2357 63410816
Acinetobacter infection 83.97 11.72 40 75809 1543 63411630
Injection site pain 82.75 11.72 26 75823 129774 63283399
Constipation 79.40 11.72 91 75758 224852 63188321
Arthritis 77.97 11.72 21 75828 115900 63297273
Metabolic acidosis 77.10 11.72 168 75681 44901 63368272
Crystal nephropathy 76.45 11.72 32 75817 904 63412269
Neutropenia 76.14 11.72 411 75438 174594 63238579
Haemodynamic instability 74.41 11.72 72 75777 9118 63404055
Haemodialysis 74.15 11.72 71 75778 8876 63404297
Erythema 73.27 11.72 408 75441 175343 63237830
Bronchial secretion retention 73.13 11.72 44 75805 2729 63410444
Bronchospasm 72.23 11.72 96 75753 17184 63395989
Rash erythematous 72.19 11.72 158 75691 42352 63370821
Contusion 72.18 11.72 45 75804 149999 63263174
Muscle spasms 72.17 11.72 49 75800 156101 63257072
Mucormycosis 71.71 11.72 44 75805 2827 63410346
Abdominal pain upper 71.26 11.72 85 75764 206359 63206814
Drug eruption 71.05 11.72 125 75724 28569 63384604
Noninfectious peritonitis 70.82 11.72 19 75830 123 63413050
Drug abuse 70.38 11.72 4 75845 72514 63340659
Respiratory distress 70.38 11.72 137 75712 33814 63379359
Gait disturbance 70.35 11.72 69 75780 183109 63230064
Hypoaesthesia 69.94 11.72 59 75790 168334 63244839
Memory impairment 69.90 11.72 19 75830 104239 63308934
Candida infection 68.26 11.72 122 75727 28229 63384944
Toxic anterior segment syndrome 68.15 11.72 36 75813 1735 63411438
Dermatitis bullous 67.66 11.72 66 75783 8442 63404731
Systemic inflammatory response syndrome 67.39 11.72 55 75794 5566 63407607
Blood cholesterol increased 67.20 11.72 15 75834 94017 63319156
Sleep disorder 67.06 11.72 9 75840 81557 63331616
Type IV hypersensitivity reaction 66.29 11.72 42 75807 2856 63410317
Haemorrhagic occlusive retinal vasculitis 66.10 11.72 12 75837 3 63413170
Mobility decreased 66.06 11.72 31 75818 121128 63292045
Feeling abnormal 65.38 11.72 49 75800 148343 63264830
Tachycardia 65.24 11.72 297 75552 117859 63295314
Endophthalmitis 65.06 11.72 45 75804 3547 63409626
Pseudomonas infection 64.19 11.72 73 75776 11140 63402033
Fibromyalgia 63.50 11.72 10 75839 80410 63332763
Face oedema 63.46 11.72 98 75751 20114 63393059
Transaminases increased 63.11 11.72 125 75724 31242 63381931
Atelectasis 61.71 11.72 100 75749 21383 63391790
Erythema multiforme 61.29 11.72 68 75781 10101 63403072
Irritable bowel syndrome 61.25 11.72 12 75837 82400 63330773
Dry mouth 60.76 11.72 10 75839 77853 63335320
Ill-defined disorder 60.56 11.72 12 75837 81743 63331430
Endocarditis 60.14 11.72 52 75797 5698 63407475
Device related sepsis 59.77 11.72 45 75804 4049 63409124
Immune effector cell-associated neurotoxicity syndrome 59.71 11.72 36 75813 2241 63410932
Intentional overdose 59.05 11.72 9 75840 74143 63339030
Acute respiratory failure 58.35 11.72 128 75721 34357 63378816
Clostridial infection 56.96 11.72 45 75804 4347 63408826
Oliguria 56.82 11.72 62 75787 9039 63404134
Psoriasis 56.16 11.72 17 75832 86940 63326233
Mental status changes 56.03 11.72 137 75712 39462 63373711
Antibiotic level below therapeutic 55.96 11.72 12 75837 23 63413150
Graft versus host disease 54.78 11.72 53 75796 6710 63406463
Infusion related reaction 53.73 11.72 135 75714 245386 63167787
Hepatic enzyme increased 53.59 11.72 100 75749 202228 63210945
Pleural effusion 53.47 11.72 237 75612 92973 63320200
Aplastic anaemia 52.59 11.72 61 75788 9508 63403665
Aspergillus infection 52.05 11.72 56 75793 8037 63405136
Geotrichum infection 51.86 11.72 20 75829 454 63412719
Suicide attempt 51.83 11.72 6 75843 60912 63352261
Gastrooesophageal reflux disease 51.32 11.72 25 75824 95614 63317559
Suicidal ideation 51.04 11.72 7 75842 62414 63350759
Thrombotic microangiopathy 50.94 11.72 63 75786 10498 63402675
Ototoxicity 50.48 11.72 27 75822 1335 63411838
Fear 50.28 11.72 77 75772 15689 63397484
Balance disorder 50.19 11.72 19 75830 84403 63328770
Dermatitis exfoliative generalised 49.36 11.72 39 75810 3768 63409405
Bronchitis 49.18 11.72 46 75803 124889 63288284
Injection site erythema 48.98 11.72 19 75830 83155 63330018
Escherichia infection 48.97 11.72 68 75781 12686 63400487
Septic embolus 48.60 11.72 23 75826 874 63412299
Platelet count decreased 47.97 11.72 269 75580 115853 63297320
Weight decreased 47.74 11.72 170 75679 276628 63136545
Shock haemorrhagic 47.69 11.72 59 75790 9836 63403337
Anhedonia 47.46 11.72 62 75787 10912 63402261
Blood alkaline phosphatase increased 46.92 11.72 135 75714 42832 63370341
Folliculitis 46.78 11.72 13 75836 70304 63342869
Status epilepticus 46.62 11.72 73 75776 15160 63398013
Drug interaction 46.14 11.72 447 75402 228684 63184489
Retinal haemorrhage 46.12 11.72 42 75807 4927 63408246
Vascular device infection 45.98 11.72 50 75799 7262 63405911
Asthenia 45.67 11.72 270 75579 383334 63029839
Off label use 45.64 11.72 1090 74759 673372 62739801
Aplasia 45.53 11.72 39 75810 4220 63408953
Staphylococcal sepsis 44.98 11.72 52 75797 8076 63405097
Staphylococcus test positive 44.37 11.72 37 75812 3859 63409314
Blood bilirubin increased 43.80 11.72 120 75729 37020 63376153
Acidosis 43.29 11.72 60 75789 11173 63402000
Pulmonary haemorrhage 43.24 11.72 48 75801 7133 63406040
Anuria 42.44 11.72 63 75786 12488 63400685
Hip arthroplasty 42.32 11.72 4 75845 47642 63365531
Depression 42.23 11.72 109 75740 196383 63216790
Lower respiratory tract infection 41.98 11.72 58 75791 132249 63280924
Clostridium test positive 41.95 11.72 33 75816 3168 63410005
Clostridium colitis 41.95 11.72 27 75822 1887 63411286
Megacolon 41.93 11.72 27 75822 1888 63411285
Hepatic function abnormal 41.82 11.72 118 75731 37024 63376149
Rhinocerebral mucormycosis 41.72 11.72 17 75832 448 63412725
Musculoskeletal pain 41.24 11.72 30 75819 92247 63320926
Factor V deficiency 41.03 11.72 11 75838 71 63413102
Hypoalbuminaemia 40.99 11.72 60 75789 11745 63401428
Capillary leak syndrome 40.88 11.72 28 75821 2172 63411001
Symmetrical drug-related intertriginous and flexural exanthema 40.39 11.72 17 75832 487 63412686
Posterior reversible encephalopathy syndrome 39.67 11.72 73 75776 17272 63395901
Alanine aminotransferase increased 39.34 11.72 235 75614 103535 63309638
Choroiditis 39.32 11.72 13 75836 185 63412988
Candida sepsis 39.27 11.72 23 75826 1357 63411816
Impaired healing 38.91 11.72 39 75810 102503 63310670
Retinal ischaemia 38.87 11.72 15 75834 341 63412832
Osteoarthritis 38.84 11.72 34 75815 95309 63317864
Paraesthesia 38.60 11.72 81 75768 156885 63256288
Fungal sepsis 38.35 11.72 22 75827 1248 63411925
Necrotising enterocolitis neonatal 38.27 11.72 13 75836 202 63412971
Pseudomonal bacteraemia 38.26 11.72 24 75825 1604 63411569
Hypersensitivity 38.08 11.72 200 75649 292485 63120688
Trichosporon infection 38.04 11.72 14 75835 278 63412895
Hypertension 37.96 11.72 188 75661 279115 63134058
Peritonitis 37.73 11.72 71 75778 17083 63396090
Product use issue 37.63 11.72 136 75713 220384 63192789
Nonspecific reaction 37.53 11.72 27 75822 2265 63410908
Migraine 37.31 11.72 41 75808 103305 63309868
Tachypnoea 37.30 11.72 71 75778 17231 63395942
Heparin-induced thrombocytopenia 37.29 11.72 36 75813 4546 63408627
Enterococcus test positive 37.25 11.72 21 75828 1152 63412021
Gamma-glutamyltransferase increased 37.23 11.72 107 75742 33924 63379249
Anaphylactic shock 35.84 11.72 84 75765 23549 63389624
Generalised oedema 35.45 11.72 66 75783 15752 63397421
Back pain 35.20 11.72 179 75670 263966 63149207
Hypokalaemia 34.93 11.72 228 75621 103576 63309597
Sinus operation 34.63 11.72 27 75822 2559 63410614
Colitis 34.62 11.72 132 75717 48396 63364777
Cytomegalovirus infection 34.57 11.72 77 75772 20875 63392298
Knee arthroplasty 34.28 11.72 11 75838 54195 63358978
Cognitive disorder 34.12 11.72 12 75837 55803 63357370
Type 2 diabetes mellitus 33.80 11.72 17 75832 63851 63349322
Dialysis 33.35 11.72 51 75798 10376 63402797
Spinal stroke 33.21 11.72 8 75841 31 63413142
Injection site swelling 33.16 11.72 8 75841 47564 63365609
Decreased appetite 32.96 11.72 171 75678 250881 63162292
Blood culture positive 32.64 11.72 34 75815 4701 63408472
Multiple sclerosis relapse 32.18 11.72 9 75840 48469 63364704
Dyspnoea 32.03 11.72 577 75272 660736 62752437
Bone marrow failure 31.95 11.72 92 75757 29198 63383975
Muscular weakness 31.91 11.72 61 75788 122292 63290881
Meningitis bacterial 31.74 11.72 20 75829 1347 63411826
Scoliosis 31.70 11.72 43 75806 7845 63405328
Torsade de pointes 31.56 11.72 57 75792 13294 63399879
Weissella infection 31.51 11.72 7 75842 17 63413156
Aspartate aminotransferase increased 31.42 11.72 200 75649 90077 63323096
Vision blurred 30.48 11.72 39 75810 91885 63321288
Pneumonia fungal 30.36 11.72 35 75814 5420 63407753
Sepsis syndrome 30.28 11.72 17 75832 925 63412248
Dyspepsia 30.26 11.72 47 75802 102149 63311024
Upper respiratory tract infection 30.23 11.72 32 75817 82015 63331158
Retinal vascular occlusion 29.61 11.72 13 75836 414 63412759
Pulmonary trichosporonosis 29.53 11.72 8 75841 54 63413119
Prothrombin time prolonged 29.50 11.72 46 75803 9518 63403655
Intentional product use issue 28.98 11.72 69 75780 127823 63285350
Dry skin 28.84 11.72 16 75833 56871 63356302
Pneumococcal infection 28.81 11.72 13 75836 442 63412731
Sleep disorder due to a general medical condition 28.76 11.72 52 75797 12136 63401037
Leuconostoc infection 28.51 11.72 6 75843 10 63413163
Birdshot chorioretinopathy 28.35 11.72 8 75841 64 63413109
Avian influenza 28.35 11.72 8 75841 64 63413109
Intentional product misuse 28.28 11.72 19 75830 60898 63352275
Exfoliative rash 28.27 11.72 25 75824 2822 63410351
Brain abscess 28.11 11.72 22 75827 2096 63411077
Hepatosplenic candidiasis 28.11 11.72 11 75838 260 63412913
Diabetes insipidus 27.98 11.72 24 75825 2601 63410572
Hepatic failure 27.96 11.72 100 75749 35556 63377617
Sciatica 27.71 11.72 4 75845 34320 63378853
Myeloma cast nephropathy 27.69 11.72 9 75840 121 63413052
Hyperbilirubinaemia 27.63 11.72 49 75800 11265 63401908
Pneumonia klebsiella 27.60 11.72 23 75826 2396 63410777
Haemolytic anaemia 27.55 11.72 46 75803 10079 63403094
Umbilical erythema 27.51 11.72 8 75841 72 63413101
Injection site reaction 27.51 11.72 18 75831 58506 63354667
Electrocardiogram QT prolonged 27.34 11.72 142 75707 59388 63353785
Pulseless electrical activity 27.24 11.72 39 75810 7482 63405691
Sinus tachycardia 27.22 11.72 77 75772 24191 63388982
Enterobacter infection 27.14 11.72 22 75827 2205 63410968
Suspected transmission of an infectious agent via product 26.95 11.72 11 75838 291 63412882
Cough 26.94 11.72 222 75627 292521 63120652
Intensive care unit acquired weakness 26.89 11.72 15 75834 806 63412367
Chest discomfort 26.82 11.72 57 75792 109912 63303261
Abscess neck 26.81 11.72 14 75835 659 63412514
Rash pustular 26.73 11.72 38 75811 7244 63405929
Gait inability 26.69 11.72 15 75834 52944 63360229
Continuous haemodiafiltration 26.55 11.72 16 75833 995 63412178
Gastrointestinal disorder 26.53 11.72 75 75774 131164 63282009
Adverse event 26.43 11.72 25 75824 67534 63345639
Central nervous system injury 26.37 11.72 9 75840 142 63413031
Urinary tract infection pseudomonal 26.36 11.72 15 75834 838 63412335
Candida endophthalmitis 26.27 11.72 7 75842 44 63413129
Purpura 26.14 11.72 48 75801 11337 63401836
Acute myeloid leukaemia 26.06 11.72 61 75788 17086 63396087
Blood urea increased 26.06 11.72 80 75769 26299 63386874
Skin exfoliation 25.77 11.72 111 75738 42991 63370182
Enterococcal bacteraemia 25.77 11.72 18 75831 1441 63411732
Hypernatraemia 25.45 11.72 38 75811 7571 63405602
Escherichia bacteraemia 25.20 11.72 27 75822 3856 63409317
Subperiosteal abscess 25.20 11.72 5 75844 5 63413168
Drug level below therapeutic 25.05 11.72 30 75819 4836 63408337
Bacterial infection 25.01 11.72 65 75784 19434 63393739
Cataract 24.91 11.72 19 75830 57034 63356139
Hyperaemia 24.79 11.72 21 75828 2238 63410935
Bacterial sepsis 24.77 11.72 27 75822 3931 63409242
Incorrect drug administration rate 24.75 11.72 27 75822 3935 63409238
Bursitis 24.35 11.72 7 75842 37034 63376139
Infusion site necrosis 24.08 11.72 7 75842 63 63413110
Abscess 23.93 11.72 58 75791 16610 63396563
Enterococcal sepsis 23.90 11.72 17 75832 1401 63411772
Cardiac valve vegetation 23.87 11.72 10 75839 283 63412890
Femur fracture 23.82 11.72 10 75839 41746 63371427
Necrosis 23.73 11.72 31 75818 5456 63407717
Chest pain 23.59 11.72 156 75693 215803 63197370
Acantholysis 23.52 11.72 5 75844 9 63413164
C-reactive protein abnormal 23.31 11.72 13 75836 46083 63367090
Pulmonary oedema 23.23 11.72 128 75721 54745 63358428
Basal cell carcinoma 23.21 11.72 3 75846 27988 63385185
Uterine fistula 23.17 11.72 5 75844 10 63413163
Excessive eye blinking 23.10 11.72 16 75833 1264 63411909
Splenic injury 23.07 11.72 9 75840 211 63412962
Night sweats 22.96 11.72 15 75834 48799 63364374
Vessel puncture site inflammation 22.92 11.72 4 75845 0 63413173
Abortion spontaneous 22.89 11.72 14 75835 47181 63365992
Neutropenic colitis 22.74 11.72 23 75826 3072 63410101
Breast cancer 22.58 11.72 15 75834 48368 63364805
Lung infiltration 22.58 11.72 52 75797 14411 63398762
Cardio-respiratory arrest 22.21 11.72 135 75714 59824 63353349
Atrial fibrillation 22.20 11.72 225 75624 116411 63296762
Eye excision 22.09 11.72 6 75843 41 63413132
Ventricular tachycardia 22.03 11.72 63 75786 19916 63393257
Unmasking of previously unidentified disease 21.96 11.72 14 75835 962 63412211
Drug ineffective 21.90 11.72 1487 74362 1043278 62369895
Coagulopathy 21.89 11.72 64 75785 20480 63392693
Generalised onset non-motor seizure 21.74 11.72 5 75844 15 63413158
Hypervolaemia 21.69 11.72 79 75770 28334 63384839
Renal tubular disorder 21.69 11.72 21 75828 2661 63410512
Hepatocellular injury 21.64 11.72 77 75772 27304 63385869
Somnolence 21.62 11.72 125 75724 178560 63234613
Renal graft infection 21.54 11.72 9 75840 253 63412920
Osteoporosis 21.53 11.72 22 75827 57316 63355857
Meningitis 21.42 11.72 34 75815 7143 63406030
Factor V inhibition 21.32 11.72 8 75841 168 63413005
Gastric disorder 21.24 11.72 9 75840 37360 63375813
Fluid retention 21.19 11.72 24 75825 59662 63353511
Pulmonary alveolar haemorrhage 21.17 11.72 27 75822 4641 63408532
Wrong technique in product usage process 21.13 11.72 26 75823 62314 63350859
Injection site pruritus 21.04 11.72 14 75835 45102 63368071
Streptococcal infection 20.95 11.72 30 75819 5757 63407416
Blood lactate dehydrogenase increased 20.90 11.72 68 75781 23048 63390125
Stomatitis 20.82 11.72 90 75759 138635 63274538
Depressed mood 20.82 11.72 11 75838 40180 63372993
Bronchial obstruction 20.76 11.72 16 75833 1491 63411682
Lymphadenopathy 20.70 11.72 96 75753 38362 63374811
Laryngeal stenosis 20.69 11.72 14 75835 1064 63412109
Joint injury 20.56 11.72 5 75844 29567 63383606
Eosinophils urine present 20.44 11.72 5 75844 21 63413152
Underdose 20.39 11.72 4 75845 27452 63385721
Thrombotic thrombocytopenic purpura 20.32 11.72 24 75825 3812 63409361
Skin test positive 20.30 11.72 12 75837 720 63412453
Intervertebral discitis 20.17 11.72 22 75827 3206 63409967
Bronchopulmonary dysplasia 20.14 11.72 10 75839 423 63412750
Sleep apnoea syndrome 20.11 11.72 5 75844 29128 63384045
Cutaneous vasculitis 20.09 11.72 28 75821 5241 63407932
Product contamination 19.89 11.72 12 75837 748 63412425
Dysgeusia 19.83 11.72 16 75833 46694 63366479
Henoch-Schonlein purpura 19.73 11.72 14 75835 1149 63412024
Anti factor Xa activity decreased 19.69 11.72 4 75845 5 63413168
Pulmonary mucormycosis 19.47 11.72 9 75840 324 63412849
Hyperhidrosis 19.39 11.72 65 75784 107771 63305402
Periphlebitis 19.27 11.72 4 75845 6 63413167
Anaphylactoid reaction 19.24 11.72 23 75826 3700 63409473
Vertigo 19.24 11.72 26 75823 59861 63353312
Lower limb fracture 19.14 11.72 3 75846 24218 63388955
Generalised tonic-clonic seizure 19.13 11.72 77 75772 28939 63384234
Blood glucose increased 19.12 11.72 45 75804 83711 63329462
Urine output decreased 19.00 11.72 42 75807 11328 63401845
Syncope 18.96 11.72 74 75775 117311 63295862
Antimicrobial susceptibility test resistant 18.82 11.72 5 75844 31 63413142
Foot deformity 18.80 11.72 5 75844 27848 63385325
Myocardial infarction 18.80 11.72 59 75790 99834 63313339
Rash macular 18.72 11.72 66 75783 23298 63389875
Blood creatine phosphokinase increased 18.68 11.72 79 75770 30351 63382822
Epidermal necrosis 18.65 11.72 13 75836 1037 63412136
Red cell distribution width abnormal 18.61 11.72 7 75842 148 63413025
Morganella infection 18.61 11.72 11 75838 660 63412513
Malnutrition 18.60 11.72 50 75799 15248 63397925
Haemostasis 18.60 11.72 8 75841 242 63412931
Therapy naive 18.55 11.72 5 75844 33 63413140
Rash 18.55 11.72 833 75016 560038 62853135
Intentional self-injury 18.54 11.72 4 75845 25683 63387490
Infusion site streaking 18.32 11.72 10 75839 515 63412658
Blood pressure fluctuation 18.28 11.72 17 75832 46300 63366873
Lip oedema 18.27 11.72 23 75826 3901 63409272
Injection site bruising 18.24 11.72 14 75835 41896 63371277
Pancreatitis haemorrhagic 18.18 11.72 10 75839 523 63412650
Electrocardiogram repolarisation abnormality 18.18 11.72 14 75835 1303 63411870
Antithrombin III 18.10 11.72 7 75842 160 63413013
Cystic fibrosis 18.09 11.72 21 75828 3275 63409898
Puerperal pyrexia 18.06 11.72 5 75844 37 63413136
Serum ferritin increased 18.05 11.72 29 75820 6153 63407020
Post procedural complication 18.01 11.72 53 75796 17021 63396152
Visual impairment 18.00 11.72 47 75802 84399 63328774
Retinal exudates 17.95 11.72 11 75838 705 63412468
Overgrowth fungal 17.80 11.72 6 75843 91 63413082
Intestinal ischaemia 17.80 11.72 32 75817 7436 63405737
Vomiting 17.78 11.72 521 75328 559096 62854077
Pregnancy 17.76 11.72 11 75838 36825 63376348
Hypopyon 17.73 11.72 11 75838 721 63412452
Endocarditis candida 17.72 11.72 5 75844 40 63413133
Neck pain 17.69 11.72 35 75814 69283 63343890
Endometrial disorder 17.63 11.72 11 75838 728 63412445
Cross sensitivity reaction 17.62 11.72 17 75832 2145 63411028
Dyspnoea exertional 17.59 11.72 28 75821 60274 63352899
Corneal opacity 17.58 11.72 11 75838 732 63412441
Neurodevelopmental disorder 17.56 11.72 7 75842 174 63412999
Electrocardiogram QRS complex prolonged 17.54 11.72 28 75821 5910 63407263
Nephropathy 17.51 11.72 29 75820 6312 63406861
Procalcitonin increased 17.50 11.72 13 75836 1146 63412027
Leukaemoid reaction 17.48 11.72 7 75842 176 63412997
Lactic acidosis 17.35 11.72 91 75758 38196 63374977
Neonatal disorder 17.34 11.72 10 75839 573 63412600
Hyperchloraemia 17.31 11.72 11 75838 752 63412421
Eosinophilic pneumonia 17.30 11.72 17 75832 2194 63410979
Allergic eosinophilia 17.19 11.72 3 75846 0 63413173
Encephalitis Japanese B 17.10 11.72 5 75844 46 63413127
Lemierre syndrome 17.06 11.72 6 75843 104 63413069
Dysphonia 17.06 11.72 19 75830 47595 63365578
Immune reconstitution inflammatory syndrome 17.03 11.72 28 75821 6056 63407117
Activated partial thromboplastin time prolonged 17.02 11.72 30 75819 6863 63406310
Death 17.02 11.72 330 75519 374051 63039122
IgA nephropathy 17.00 11.72 10 75839 595 63412578
Hip fracture 16.91 11.72 7 75842 29467 63383706
Nosocomial infection 16.87 11.72 15 75834 1706 63411467
Enterocolitis haemorrhagic 16.85 11.72 14 75835 1452 63411721
Compartment syndrome 16.83 11.72 17 75832 2267 63410906
Ischaemic enteritis 16.82 11.72 5 75844 49 63413124
Neonatal anuria 16.82 11.72 5 75844 49 63413124
Pulse absent 16.79 11.72 26 75823 5348 63407825
Toxic encephalopathy 16.72 11.72 29 75820 6550 63406623
Drug clearance decreased 16.70 11.72 14 75835 1470 63411703
Hot flush 16.65 11.72 22 75827 51137 63362036
Enterocolitis 16.63 11.72 32 75817 7826 63405347
Metabolic encephalopathy 16.62 11.72 27 75822 5782 63407391
Drug monitoring procedure incorrectly performed 16.62 11.72 7 75842 201 63412972
Chronic obstructive pulmonary disease 16.56 11.72 31 75818 62655 63350518
Peripheral sensorimotor neuropathy 16.55 11.72 14 75835 1489 63411684
Petechiae 16.48 11.72 45 75804 13852 63399321
Lactobacillus infection 16.46 11.72 5 75844 53 63413120
Drug level decreased 16.46 11.72 32 75817 7887 63405286
Unresponsive to stimuli 16.46 11.72 82 75767 33734 63379439
Chorioretinopathy 16.35 11.72 11 75838 828 63412345
CNS ventriculitis 16.22 11.72 6 75843 121 63413052
Multiple-drug resistance 16.13 11.72 25 75824 5145 63408028
Acute graft versus host disease 16.09 11.72 23 75826 4405 63408768
Hypercholesterolaemia 16.07 11.72 3 75846 21331 63391842
Hypochromasia 15.99 11.72 8 75841 344 63412829
Limbal swelling 15.95 11.72 4 75845 19 63413154
Transient ischaemic attack 15.94 11.72 13 75836 37740 63375433
Altered state of consciousness 15.88 11.72 66 75783 25164 63388009
Differentiation syndrome 15.83 11.72 12 75837 1091 63412082
Lung abscess 15.81 11.72 15 75834 1853 63411320
Myasthenia gravis crisis 15.81 11.72 9 75840 503 63412670
Obesity 15.80 11.72 8 75841 29944 63383229
Pulmonary necrosis 15.73 11.72 6 75843 132 63413041
Hepatitis fulminant 15.65 11.72 20 75829 3444 63409729
Anal skin tags 15.63 11.72 9 75840 514 63412659
Fibrosis 15.57 11.72 22 75827 4170 63409003
Myoclonus 15.56 11.72 48 75801 15820 63397353
Burkholderia test positive 15.52 11.72 7 75842 238 63412935
Wound haemorrhage 15.46 11.72 17 75832 2499 63410674
Biliary sepsis 15.32 11.72 11 75838 920 63412253
Nervousness 15.29 11.72 9 75840 30970 63382203
Inappropriate schedule of product administration 15.26 11.72 68 75781 103897 63309276
Pulmonary fibrosis 15.26 11.72 15 75834 39794 63373379
Vanishing bile duct syndrome 15.24 11.72 10 75839 722 63412451
Pruritus 15.21 11.72 551 75298 360902 63052271
Adenovirus infection 15.17 11.72 20 75829 3551 63409622
SJS-TEN overlap 15.15 11.72 8 75841 385 63412788
Citrobacter sepsis 15.12 11.72 3 75846 3 63413170
Neonatal respiratory distress 15.12 11.72 8 75841 387 63412786
Central nervous system vasculitis 15.08 11.72 11 75838 943 63412230
Respiratory gas exchange disorder 15.06 11.72 8 75841 390 63412783
Enterocolitis bacterial 15.02 11.72 7 75842 257 63412916
Psychotic disorder 14.92 11.72 6 75843 25706 63387467
Human herpesvirus 6 infection 14.84 11.72 18 75831 2939 63410234
Procedural anxiety 14.71 11.72 10 75839 766 63412407
Renal disorder 14.69 11.72 78 75771 32896 63380277
Empyema 14.64 11.72 15 75834 2034 63411139
Thrombosis 14.61 11.72 35 75814 64720 63348453
Eosinophil count increased 14.60 11.72 37 75812 10891 63402282
Renal abscess 14.55 11.72 10 75839 780 63412393
Eosinophilic pneumonia acute 14.55 11.72 8 75841 418 63412755
Hepatitis cholestatic 14.55 11.72 28 75821 6850 63406323
Haemorrhage intracranial 14.49 11.72 42 75807 13377 63399796
Escherichia test positive 14.46 11.72 16 75833 2368 63410805
Premature delivery 14.44 11.72 73 75776 30208 63382965
Nasal congestion 14.42 11.72 36 75813 65624 63347549
Bronchial anastomosis complication 14.40 11.72 4 75845 30 63413143
Influenza like illness 14.39 11.72 37 75812 66787 63346386
Circulatory collapse 14.29 11.72 58 75791 21880 63391293
Lung neoplasm malignant 14.29 11.72 3 75846 19630 63393543
Holmes-Adie pupil 14.29 11.72 4 75845 31 63413142
Implant site hypersensitivity 14.29 11.72 4 75845 31 63413142
Abdominal abscess 14.28 11.72 22 75827 4504 63408669
Lung consolidation 14.28 11.72 21 75828 4127 63409046
Asymptomatic bacteriuria 14.25 11.72 7 75842 289 63412884
Supraventricular tachyarrhythmia 14.25 11.72 5 75844 86 63413087
Red blood cell sedimentation rate increased 14.23 11.72 19 75830 43963 63369210
Rash pruritic 14.22 11.72 121 75728 59678 63353495
Nervous system disorder 14.17 11.72 52 75797 18714 63394459
Epstein-Barr virus test positive 14.15 11.72 9 75840 616 63412557
Meningococcal infection 14.09 11.72 5 75844 89 63413084
Vaginal abscess 14.06 11.72 8 75841 447 63412726
Pneumonia necrotising 14.02 11.72 8 75841 449 63412724
Serratia sepsis 13.99 11.72 5 75844 91 63413082
Abdominal sepsis 13.94 11.72 12 75837 1307 63411866
Complications of transplanted kidney 13.92 11.72 16 75833 2470 63410703
Road traffic accident 13.81 11.72 14 75835 36618 63376555
Respiratory acidosis 13.79 11.72 27 75822 6688 63406485
Drug dependence 13.75 11.72 6 75843 24477 63388696
Osteonecrosis of jaw 13.73 11.72 13 75836 35110 63378063
Liver abscess 13.72 11.72 17 75832 2837 63410336
Lower respiratory tract infection bacterial 13.72 11.72 8 75841 468 63412705
Serum sickness 13.70 11.72 17 75832 2843 63410330
Electrocardiogram ST segment elevation 13.69 11.72 20 75829 3907 63409266
Adverse drug reaction 13.69 11.72 49 75800 79665 63333508
Uterine necrosis 13.59 11.72 3 75846 7 63413166
Carpal tunnel syndrome 13.56 11.72 4 75845 20813 63392360
Confusional state 13.44 11.72 200 75649 236180 63176993
Pharyngeal inflammation 13.43 11.72 9 75840 673 63412500
Injection site rash 13.43 11.72 3 75846 18806 63394367
Candida test positive 13.42 11.72 10 75839 886 63412287
Ear pain 13.40 11.72 14 75835 36104 63377069
Endotracheal intubation 13.39 11.72 16 75833 2572 63410601
Vulvovaginitis 13.39 11.72 7 75842 330 63412843
Amnesia 13.39 11.72 29 75820 55556 63357617
Bandaemia 13.38 11.72 4 75845 40 63413133
Device related bacteraemia 13.38 11.72 6 75843 201 63412972
Device dislocation 13.36 11.72 7 75842 25698 63387475
Rib fracture 13.36 11.72 58 75791 22539 63390634
Enterocutaneous fistula 13.34 11.72 12 75837 1385 63411788
Neutrophil count decreased 13.34 11.72 114 75735 56292 63356881
Panic attack 13.31 11.72 5 75844 22326 63390847
Pulmonary hypertensive crisis 13.26 11.72 7 75842 337 63412836
Chemical peritonitis 13.24 11.72 5 75844 107 63413066
Electrocardiogram T wave alternans 13.21 11.72 4 75845 42 63413131
Venoocclusive liver disease 13.20 11.72 22 75827 4813 63408360
Emotional distress 13.16 11.72 75 75774 32474 63380699
Dehiscence 13.11 11.72 5 75844 110 63413063
Device issue 13.08 11.72 6 75843 23775 63389398
Glutamate dehydrogenase level abnormal 13.05 11.72 3 75846 9 63413164
Deafness bilateral 13.02 11.72 12 75837 1430 63411743
Hydrocephalus 13.00 11.72 23 75826 5277 63407896
Abscess limb 12.99 11.72 22 75827 4876 63408297
Renal infarct 12.98 11.72 12 75837 1435 63411738
Blood pressure systolic increased 12.91 11.72 23 75826 47374 63365799
Bacterial endophthalmitis 12.90 11.72 5 75844 115 63413058
Bronchopleural fistula 12.90 11.72 6 75843 219 63412954
Systemic mycosis 12.87 11.72 11 75838 1186 63411987
Premature baby 12.86 11.72 54 75795 20681 63392492
Mood swings 12.85 11.72 3 75846 18245 63394928
Extravasation 12.83 11.72 15 75834 2357 63410816
Mucosal inflammation 12.81 11.72 98 75751 46830 63366343
Levator syndrome 12.81 11.72 3 75846 10 63413163
Deafness permanent 12.81 11.72 3 75846 10 63413163
Incision site swelling 12.75 11.72 6 75843 225 63412948
Diabetes mellitus 12.73 11.72 30 75819 55780 63357393
Pseudomonal sepsis 12.68 11.72 15 75834 2386 63410787
Joint range of motion decreased 12.68 11.72 12 75837 32416 63380757
Acne 12.63 11.72 6 75843 23287 63389886
Myalgia 12.62 11.72 113 75736 146416 63266757
Pneumonia bacterial 12.60 11.72 32 75817 9433 63403740
Histology abnormal 12.59 11.72 5 75844 123 63413050
Haemolytic transfusion reaction 12.59 11.72 3 75846 11 63413162
Transverse sinus thrombosis 12.55 11.72 8 75841 550 63412623
Hepatitis 12.53 11.72 86 75763 39702 63373471
Fibromuscular dysplasia 12.49 11.72 6 75843 236 63412937
Gas gangrene 12.44 11.72 5 75844 127 63413046
Heavy menstrual bleeding 12.36 11.72 3 75846 17770 63395403
Granulomatous liver disease 12.36 11.72 9 75840 769 63412404
Amniotic cavity infection 12.36 11.72 11 75838 1252 63411921
Osteomyelitis acute 12.35 11.72 6 75843 242 63412931
Erythrosis 12.29 11.72 4 75845 54 63413119
Blood pressure increased 12.26 11.72 129 75720 161933 63251240
Hyperthermia 12.23 11.72 31 75818 9125 63404048
Superior sagittal sinus thrombosis 12.23 11.72 9 75840 782 63412391
Febrile bone marrow aplasia 12.17 11.72 27 75822 7298 63405875
Rhinorrhoea 12.15 11.72 39 75810 65538 63347635
Haemothorax 12.13 11.72 14 75835 2171 63411002
Blister 12.12 11.72 98 75751 129716 63283457
Cardiac tamponade 12.07 11.72 21 75828 4754 63408419
Laryngeal inflammation 12.05 11.72 5 75844 138 63413035
Manipulation 12.03 11.72 4 75845 58 63413115
Viral myositis 12.01 11.72 3 75846 14 63413159
Seasonal allergy 11.98 11.72 5 75844 20945 63392228
Systolic dysfunction 11.96 11.72 12 75837 1587 63411586
Cerebral aspergillosis 11.92 11.72 7 75842 415 63412758
Idiosyncratic drug reaction 11.86 11.72 9 75840 819 63412354
Disturbance in attention 11.85 11.72 17 75832 38172 63375001
Cardiac disorder 11.84 11.72 27 75822 50789 63362384
Adenovirus reactivation 11.79 11.72 5 75844 146 63413027
Brain herniation 11.78 11.72 18 75831 3659 63409514
Culture urine positive 11.74 11.72 18 75831 3669 63409504
Disseminated cryptococcosis 11.72 11.72 7 75842 428 63412745

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 2091.63 11.73 1188 84509 31824 34839410
Acute kidney injury 1128.65 11.73 2371 83326 302617 34568617
Linear IgA disease 1066.02 11.73 315 85382 1311 34869923
Renal tubular necrosis 564.45 11.73 395 85302 15285 34855949
Multiple organ dysfunction syndrome 466.00 11.73 741 84956 75825 34795409
Eosinophilia 427.71 11.73 417 85280 25805 34845429
Rash maculo-papular 395.55 11.73 415 85282 28036 34843198
Septic shock 384.16 11.73 656 85041 71178 34800056
Toxic epidermal necrolysis 371.41 11.73 354 85343 21292 34849942
Fatigue 366.76 11.73 229 85468 370424 34500810
Tubulointerstitial nephritis 357.25 11.73 342 85355 20682 34850552
Pathogen resistance 320.65 11.73 230 85467 9252 34861982
Drug ineffective 313.38 11.73 2048 83649 454703 34416531
Nephropathy toxic 293.72 11.73 245 85452 12343 34858891
Drug resistance 266.04 11.73 323 85374 25604 34845630
Pyrexia 254.92 11.73 1537 84160 331476 34539758
Acute generalised exanthematous pustulosis 249.13 11.73 173 85524 6603 34864631
Antibiotic level above therapeutic 247.89 11.73 67 85630 184 34871050
Dizziness 221.17 11.73 131 85566 218390 34652844
Drug abuse 218.85 11.73 5 85692 99091 34772143
Staphylococcal infection 214.20 11.73 328 85369 32432 34838802
Fall 210.46 11.73 118 85579 202767 34668467
Rash morbilliform 208.28 11.73 116 85581 2971 34868263
Antimicrobial susceptibility test resistant 204.43 11.73 63 85634 311 34870923
Renal failure 203.85 11.73 743 84954 129814 34741420
Renal impairment 202.43 11.73 599 85098 93914 34777320
Respiratory failure 189.37 11.73 641 85056 107931 34763303
Product dose omission issue 184.44 11.73 35 85662 119676 34751558
Death 183.06 11.73 445 85252 397604 34473630
Sepsis 178.26 11.73 844 84853 165717 34705517
Enterococcal infection 162.99 11.73 154 85543 9152 34862082
Nausea 162.53 11.73 372 85325 339536 34531698
Blood creatinine increased 162.29 11.73 557 85140 94419 34776815
Drug hypersensitivity 160.74 11.73 498 85199 80031 34791203
Drug ineffective for unapproved indication 148.77 11.73 233 85464 23482 34847752
Clostridium difficile infection 146.36 11.73 205 85492 18693 34852541
Stevens-Johnson syndrome 136.69 11.73 197 85500 18442 34852792
Thrombocytopenia 133.75 11.73 744 84953 155503 34715731
Arthralgia 132.39 11.73 133 85564 169908 34701326
Rash 130.98 11.73 964 84733 221788 34649446
Toxic skin eruption 126.89 11.73 148 85549 11237 34859997
Drug level increased 126.16 11.73 208 85489 21888 34849346
Acute respiratory distress syndrome 121.62 11.73 224 85473 25745 34845489
Asthenia 119.80 11.73 265 85432 244986 34626248
Weight decreased 119.74 11.73 154 85543 176147 34695087
Candida infection 116.63 11.73 178 85519 17537 34853697
Clostridium difficile colitis 116.43 11.73 167 85530 15563 34855671
Haemophagocytic lymphohistiocytosis 114.55 11.73 150 85547 12823 34858411
Choroiditis 114.24 11.73 57 85640 1158 34870076
Renal injury 114.02 11.73 139 85558 11056 34860178
Constipation 113.79 11.73 101 85596 136881 34734353
Decreased appetite 113.34 11.73 145 85552 166247 34704987
Aplastic anaemia 107.77 11.73 126 85571 9590 34861644
Systemic candida 107.13 11.73 82 85615 3644 34867590
Headache 107.05 11.73 206 85491 200429 34670805
Retinal vasculitis 106.87 11.73 40 85657 386 34870848
Disseminated intravascular coagulation 104.45 11.73 190 85507 21626 34849608
Endocarditis 99.50 11.73 100 85597 6411 34864823
Insomnia 98.46 11.73 67 85630 103840 34767394
Muscle spasms 97.82 11.73 31 85666 74970 34796264
Fungaemia 97.76 11.73 67 85630 2501 34868733
Staphylococcal bacteraemia 97.76 11.73 112 85585 8340 34862894
Pseudomembranous colitis 95.02 11.73 68 85629 2723 34868511
Haemodynamic instability 94.97 11.73 117 85580 9406 34861828
Haemodialysis 93.38 11.73 122 85575 10404 34860830
Nasopharyngitis 92.90 11.73 28 85669 69940 34801294
Aspergillus infection 92.02 11.73 131 85566 12123 34859111
Bacteraemia 90.96 11.73 169 85528 19548 34851686
Pain in extremity 90.59 11.73 106 85591 126407 34744827
Immune thrombocytopenia 85.77 11.73 109 85588 9043 34862191
Rash erythematous 85.35 11.73 189 85508 24788 34846446
Pancytopenia 84.56 11.73 458 85239 94699 34776535
Device related sepsis 84.41 11.73 66 85631 3027 34868207
Fear 83.13 11.73 115 85582 10361 34860873
Kounis syndrome 82.64 11.73 60 85637 2458 34868776
Klebsiella infection 82.17 11.73 103 85594 8428 34862806
Peripheral swelling 81.41 11.73 43 85654 76498 34794736
Back pain 80.96 11.73 108 85589 121681 34749553
Feeling abnormal 80.93 11.73 27 85670 63208 34808026
Pseudomonas infection 78.12 11.73 122 85575 12260 34858974
Myocardial infarction 77.85 11.73 110 85587 120975 34750259
Rheumatoid arthritis 77.17 11.73 4 85693 38234 34833000
Shock 77.09 11.73 178 85519 24001 34847233
Anaphylactic reaction 77.05 11.73 213 85484 32088 34839146
Gait disturbance 76.58 11.73 58 85639 85082 34786152
Drug eruption 75.37 11.73 157 85540 19741 34851493
Ototoxicity 75.32 11.73 51 85646 1866 34869368
Leukocytosis 72.19 11.73 173 85524 23892 34847342
Minimum inhibitory concentration 72.09 11.73 24 85673 158 34871076
Prostate cancer 71.83 11.73 7 85690 39642 34831592
Weight increased 69.80 11.73 75 85622 92958 34778276
Drug dispensed to wrong patient 68.98 11.73 31 85666 493 34870741
Depression 68.79 11.73 82 85615 97016 34774218
Coronary artery disease 68.48 11.73 17 85680 48288 34822946
Syncope 68.30 11.73 74 85623 91377 34779857
Agranulocytosis 67.99 11.73 168 85529 23653 34847581
Abdominal discomfort 67.58 11.73 31 85666 59804 34811430
Intentional overdose 66.71 11.73 13 85684 43661 34827573
Anhedonia 65.87 11.73 87 85610 7498 34863736
Suicide attempt 65.64 11.73 9 85688 39107 34832127
Injury 65.62 11.73 152 85545 20535 34850699
Diarrhoea 65.54 11.73 626 85071 389286 34481948
Leukopenia 65.19 11.73 316 85381 62540 34808694
Oliguria 65.01 11.73 91 85606 8289 34862945
Dyspnoea 65.00 11.73 601 85096 376181 34495053
Dehydration 63.68 11.73 140 85557 129829 34741405
Joint swelling 63.16 11.73 34 85663 59856 34811378
Nephropathy 62.75 11.73 75 85622 5842 34865392
Hypoxia 62.27 11.73 284 85413 54811 34816423
Hospitalisation 61.94 11.73 31 85666 56871 34814363
Trichosporon infection 61.91 11.73 32 85665 702 34870532
Blood pressure increased 60.72 11.73 76 85621 88026 34783208
Cardiac failure congestive 60.40 11.73 69 85628 83201 34788033
Abdominal pain upper 60.17 11.73 52 85645 71438 34799796
Musculoskeletal stiffness 59.60 11.73 20 85677 46660 34824574
Hypotension 58.79 11.73 814 84883 220835 34650399
Injection site pain 58.76 11.73 12 85685 38993 34832241
Device related infection 58.39 11.73 130 85567 17107 34854127
Treatment failure 58.30 11.73 248 85449 46449 34824785
Cardiac valve vegetation 58.19 11.73 27 85670 464 34870770
Nephritis 57.76 11.73 48 85649 2403 34868831
Henoch-Schonlein purpura 57.75 11.73 41 85656 1621 34869613
Mucormycosis 57.64 11.73 72 85625 5870 34865364
Myalgia 57.50 11.73 73 85624 84037 34787197
Myeloma cast nephropathy 57.43 11.73 16 85681 51 34871183
Therapeutic response delayed 57.25 11.73 29 85668 609 34870625
Malaise 57 11.73 248 85449 185577 34685657
Drug intolerance 56.95 11.73 38 85659 59532 34811702
Cross sensitivity reaction 56.88 11.73 38 85659 1359 34869875
Neurotoxicity 56.76 11.73 132 85565 17878 34853356
Venoocclusive liver disease 56.65 11.73 83 85614 7883 34863351
Blood culture positive 56.36 11.73 64 85633 4719 34866515
Vomiting 56.20 11.73 366 85331 247255 34623979
Neuropathy peripheral 56.16 11.73 73 85624 83190 34788044
Emotional distress 55.09 11.73 117 85580 14909 34856325
Encephalopathy 54.94 11.73 201 85496 35118 34836116
Herpes simplex oesophagitis 54.76 11.73 20 85677 179 34871055
Psoriasis 54.36 11.73 14 85683 38798 34832436
Dialysis 54.13 11.73 98 85599 11110 34860124
Enterococcal bacteraemia 52.90 11.73 41 85656 1856 34869378
Memory impairment 52.85 11.73 20 85677 43298 34827936
Purpura 52.16 11.73 92 85605 10219 34861015
Geotrichum infection 51.42 11.73 25 85672 479 34870755
Cough 51.30 11.73 192 85505 149948 34721286
Dysbiosis 50.50 11.73 25 85672 499 34870735
Dry mouth 50.47 11.73 7 85690 30158 34841076
Eosinophilic pneumonia 50.27 11.73 52 85645 3449 34867785
Megacolon 50.21 11.73 39 85658 1771 34869463
Erythema 49.02 11.73 379 85318 88401 34782833
Myeloid maturation arrest 48.60 11.73 11 85686 9 34871225
Dermatitis exfoliative 48.41 11.73 70 85627 6569 34864665
Loss of personal independence in daily activities 48.36 11.73 11 85686 33168 34838066
Neutropenia 48.32 11.73 592 85105 156186 34715048
Chest pain 48.08 11.73 155 85542 126607 34744627
Transaminases increased 48.08 11.73 160 85537 26663 34844571
Dyspnoea exertional 47.98 11.73 23 85674 43256 34827978
Hepatocellular injury 47.65 11.73 141 85556 22070 34849164
Transient ischaemic attack 47.18 11.73 6 85691 27607 34843627
Antibiotic level below therapeutic 47.03 11.73 14 85683 60 34871174
Blood glucose increased 46.54 11.73 57 85640 66661 34804573
Dyspepsia 46.44 11.73 16 85681 36716 34834518
Skin necrosis 46.06 11.73 64 85633 5789 34865445
Septic embolus 45.79 11.73 32 85665 1233 34870001
Pneumonia staphylococcal 45.39 11.73 46 85651 2978 34868256
Muscular weakness 45.07 11.73 68 85629 72829 34798405
Staphylococcal sepsis 44.92 11.73 84 85613 9760 34861474
Graft versus host disease 44.31 11.73 87 85610 10482 34860752
Condition aggravated 43.90 11.73 688 85009 191508 34679726
Gastrooesophageal reflux disease 43.83 11.73 19 85678 37905 34833329
Asthma 43.83 11.73 25 85672 42631 34828603
Face oedema 43.76 11.73 91 85606 11425 34859809
Fungal peritonitis 43.68 11.73 26 85671 757 34870477
Suicidal ideation 42.47 11.73 23 85674 40365 34830869
Acinetobacter infection 42.45 11.73 30 85667 1177 34870057
Therapeutic product effect decreased 42.45 11.73 16 85681 34727 34836507
Brain abscess 42.34 11.73 45 85652 3080 34868154
Off label use 41.75 11.73 1333 84364 418191 34453043
Wrong technique in product usage process 41.64 11.73 18 85679 35968 34835266
Staphylococcus test positive 41.62 11.73 45 85652 3141 34868093
Balance disorder 41.53 11.73 24 85673 40630 34830604
Malignant neoplasm progression 41.34 11.73 97 85600 87949 34783285
Hypoaesthesia 41.29 11.73 54 85643 61390 34809844
Pain 40.79 11.73 314 85383 204361 34666873
Cholestasis 40.76 11.73 152 85545 26796 34844438
Cardiac disorder 40.56 11.73 28 85669 43098 34828136
Nephrolithiasis 40.50 11.73 12 85685 30321 34840913
Product contamination 40.34 11.73 24 85673 698 34870536
Therapy non-responder 39.99 11.73 196 85501 38950 34832284
Fungal infection 39.91 11.73 107 85590 15828 34855406
Therapeutic product effect incomplete 39.86 11.73 39 85658 50502 34820732
Endophthalmitis 39.75 11.73 46 85651 3462 34867772
Respiratory distress 39.65 11.73 183 85514 35482 34835752
Cerebrovascular accident 39.37 11.73 94 85603 84717 34786517
Heparin-induced thrombocytopenia 39.36 11.73 58 85639 5537 34865697
Tachycardia 39.34 11.73 348 85349 84424 34786810
Dermatitis exfoliative generalised 39.33 11.73 47 85650 3660 34867574
Arthropathy 39.06 11.73 9 85688 26898 34844336
Blood cholesterol increased 38.91 11.73 3 85694 20540 34850694
Cytokine release syndrome 38.83 11.73 134 85563 22743 34848491
Fungal sepsis 38.83 11.73 25 85672 839 34870395
Enterococcus test positive 38.60 11.73 27 85670 1042 34870192
Mental status changes 38.42 11.73 190 85507 37893 34833341
Sleep apnoea syndrome 38.40 11.73 3 85694 20318 34850916
Febrile neutropenia 38.02 11.73 507 85190 136342 34734892
Dermatitis bullous 37.94 11.73 64 85633 6858 34864376
Inappropriate schedule of product administration 37.66 11.73 59 85638 62237 34808997
Immune effector cell-associated neurotoxicity syndrome 37.64 11.73 46 85651 3667 34867567
Drug dependence 37.42 11.73 7 85690 24210 34847024
Bronchopulmonary aspergillosis 37.28 11.73 99 85598 14560 34856674
Intentional product misuse 36.20 11.73 35 85662 45576 34825658
Depressed mood 36.09 11.73 3 85694 19314 34851920
Intraocular pressure increased 35.29 11.73 54 85643 5329 34865905
Stenotrophomonas infection 35.20 11.73 34 85663 2076 34869158
Drug-induced liver injury 35.11 11.73 152 85545 28680 34842554
Mobility decreased 34.97 11.73 15 85682 30113 34841121
Escherichia infection 34.72 11.73 68 85629 8177 34863057
Thrombosis 34.25 11.73 44 85653 50414 34820820
Erectile dysfunction 34.03 11.73 5 85692 20632 34850602
Generalised oedema 33.82 11.73 86 85611 12322 34858912
Cataract 33.81 11.73 11 85686 26175 34845059
Endocarditis candida 33.77 11.73 11 85686 67 34871167
Human herpesvirus 6 infection 33.72 11.73 33 85664 2048 34869186
Organ failure 33.58 11.73 33 85664 2058 34869176
Meningitis candida 33.36 11.73 11 85686 70 34871164
Gout 33.34 11.73 4 85693 19249 34851985
Cytomegalovirus enterocolitis 33.34 11.73 24 85673 970 34870264
Clostridium test positive 33.22 11.73 41 85656 3301 34867933
Venoocclusive disease 33.16 11.73 38 85659 2829 34868405
Alveolar lung disease 33.05 11.73 17 85680 369 34870865
Influenza 33.01 11.73 44 85653 49622 34821612
Petechiae 32.99 11.73 72 85625 9346 34861888
Eosinophil count increased 32.88 11.73 68 85629 8504 34862730
Loss of consciousness 32.80 11.73 99 85598 82568 34788666
Hypertension 32.78 11.73 198 85499 136245 34734989
Epidermolysis bullosa 32.41 11.73 12 85685 112 34871122
Somnolence 32.40 11.73 151 85546 110965 34760269
Bronchitis 32.38 11.73 33 85664 41930 34829304
Nervous system disorder 31.84 11.73 93 85604 14450 34856784
Chest discomfort 31.69 11.73 53 85644 54477 34816757
Palpitations 31.36 11.73 31 85666 39955 34831279
Overdose 31.36 11.73 116 85581 90943 34780291
Vision blurred 31.28 11.73 40 85657 45923 34825311
Contusion 31.13 11.73 26 85671 36338 34834896
Pulmonary interstitial emphysema syndrome 30.81 11.73 18 85679 506 34870728
Hot flush 30.68 11.73 4 85693 18062 34853172
Diabetes mellitus 30.67 11.73 42 85655 46831 34824403
Foetal exposure during pregnancy 30.51 11.73 29 85668 38072 34833162
Vascular device infection 30.33 11.73 44 85653 4141 34867093
Hypoglycaemia 30.03 11.73 55 85642 54585 34816649
Pleocytosis 29.94 11.73 18 85679 534 34870700
Dry skin 29.84 11.73 20 85677 31267 34839967
Pollakiuria 29.74 11.73 6 85691 19668 34851566
Aggression 29.66 11.73 31 85666 38933 34832301
Pyelonephritis fungal 29.27 11.73 10 85687 72 34871162
COVID-19 29.26 11.73 95 85602 77455 34793779
Bladder cancer 29.15 11.73 3 85694 16275 34854959
Systemic inflammatory response syndrome 29.07 11.73 56 85641 6653 34864581
Chronic obstructive pulmonary disease 28.93 11.73 47 85650 48871 34822363
Hyperammonaemia 28.64 11.73 54 85643 6313 34864921
Aminoaciduria 28.44 11.73 14 85683 276 34870958
Osteoarthritis 27.86 11.73 8 85689 20634 34850600
Enterobacter infection 27.76 11.73 32 85665 2398 34868836
Pulmonary haemorrhage 27.65 11.73 71 85626 10233 34861001
Eosinophilic pneumonia acute 27.61 11.73 17 85680 527 34870707
Nosocomial infection 27.39 11.73 23 85674 1168 34870066
Anuria 27.29 11.73 71 85626 10314 34860920
Fluid retention 27.28 11.73 16 85681 26871 34844363
Sinusitis 27.18 11.73 37 85660 41365 34829869
Osteomyelitis 26.94 11.73 94 85603 16042 34855192
Inflammatory marker increased 26.91 11.73 46 85651 4982 34866252
Crystalluria 26.91 11.73 16 85681 465 34870769
Drug level above therapeutic 26.89 11.73 42 85655 4219 34867015
Liver injury 26.88 11.73 89 85608 14789 34856445
Hepatic function abnormal 26.50 11.73 193 85504 44170 34827064
Presyncope 26.44 11.73 7 85690 19052 34852182
Urinary retention 26.37 11.73 30 85667 36258 34834976
Disseminated cryptococcosis 26.32 11.73 24 85673 1362 34869872
Gait inability 26.31 11.73 9 85688 20749 34850485
Hyperbilirubinaemia 26.30 11.73 96 85601 16747 34854487
Mediastinitis 26.12 11.73 18 85679 678 34870556
Device related bacteraemia 26.02 11.73 15 85682 411 34870823
Nasal congestion 25.94 11.73 12 85685 23045 34848189
Neck pain 25.84 11.73 15 85682 25334 34845900
Uveitis 25.71 11.73 57 85640 7478 34863756
Diffuse alveolar damage 25.64 11.73 30 85667 2284 34868950
Type IV hypersensitivity reaction 25.62 11.73 24 85673 1410 34869824
Muscle abscess 25.57 11.73 17 85680 603 34870631
Prostatic specific antigen increased 25.54 11.73 3 85694 14677 34856557
Sleep disorder 25.51 11.73 24 85673 31664 34839570
Hypoperfusion 25.48 11.73 22 85675 1161 34870073
Coagulopathy 25.38 11.73 106 85591 19683 34851551
Cognitive disorder 25.20 11.73 20 85677 28673 34842561
Procalcitonin increased 25.13 11.73 26 85671 1725 34869509
Migraine 25.06 11.73 6 85691 17472 34853762
Dysuria 25.04 11.73 18 85679 27134 34844100
Rhinorrhoea 25.03 11.73 16 85681 25652 34845582
Hypoalbuminaemia 24.90 11.73 76 85621 12098 34859136
Nightmare 24.89 11.73 3 85694 14388 34856846
Aortoenteric fistula 24.86 11.73 10 85687 119 34871115
Lactobacillus infection 24.83 11.73 13 85684 293 34870941
Eye pain 24.74 11.73 81 85616 13381 34857853
Influenza like illness 24.60 11.73 19 85678 27615 34843619
Noninfectious peritonitis 24.56 11.73 10 85687 123 34871111
Metabolic acidosis 24.38 11.73 187 85510 43493 34827741
Blood urea increased 24.18 11.73 142 85555 30222 34841012
Psychotic disorder 24.18 11.73 15 85682 24437 34846797
Cutaneous vasculitis 24.14 11.73 40 85657 4223 34867011
Candida test positive 24.14 11.73 14 85683 388 34870846
Cryptococcal meningoencephalitis 24.13 11.73 10 85687 129 34871105
Basal cell carcinoma 24.10 11.73 9 85688 19649 34851585
Hypersensitivity vasculitis 24.08 11.73 35 85662 3300 34867934
Alopecia 24.00 11.73 15 85682 24340 34846894
Wrong patient received product 23.91 11.73 31 85666 2623 34868611
Hyper IgE syndrome 23.73 11.73 8 85689 55 34871179
Cell death 23.56 11.73 29 85668 2328 34868906
Rash macular 23.36 11.73 77 85620 12765 34858469
Clostridial infection 23.24 11.73 36 85661 3591 34867643
Blood bilirubin increased 23.10 11.73 167 85530 38129 34833105
Serum sickness-like reaction 23.08 11.73 10 85687 145 34871089
Acidosis 23.01 11.73 69 85628 10876 34860358
Aeromonas infection 22.86 11.73 12 85685 272 34870962
CNS ventriculitis 22.70 11.73 12 85685 276 34870958
Productive cough 22.67 11.73 36 85661 37777 34833457
Unevaluable event 22.55 11.73 147 85550 32443 34838791
Necrotising fasciitis 22.54 11.73 36 85661 3686 34867548
Flatulence 22.39 11.73 12 85685 21186 34850048
Fungal test positive 22.29 11.73 15 85682 543 34870691
Fungal endocarditis 22.20 11.73 13 85684 367 34870867
Botulism 22.14 11.73 10 85687 161 34871073
Full blood count abnormal 22.14 11.73 9 85688 18659 34852575
Procalcitonin abnormal 22.14 11.73 13 85684 369 34870865
Differentiation syndrome 21.81 11.73 22 85675 1416 34869818
Pulmonary embolism 21.66 11.73 130 85567 89616 34781618
Renal tubular disorder 21.66 11.73 40 85657 4603 34866631
Hyperthermia 21.60 11.73 66 85631 10511 34860723
Wheezing 21.59 11.73 43 85654 41359 34829875
Erythema multiforme 21.58 11.73 58 85639 8591 34862643
Hepatosplenic candidiasis 21.54 11.73 11 85686 235 34870999
Cerebral cyst 21.52 11.73 12 85685 308 34870926
Neoplasm malignant 21.42 11.73 11 85686 19894 34851340
Dysgeusia 21.41 11.73 20 85677 26477 34844757
Clostridium bacteraemia 21.28 11.73 10 85687 177 34871057
Osteomyelitis fungal 21.25 11.73 11 85686 242 34870992
Hypernatraemia 21.25 11.73 57 85640 8433 34862801
Pneumonia fungal 21.24 11.73 51 85646 7049 34864185
Infective aneurysm 21.19 11.73 15 85682 590 34870644
Cardiac valve abscess 21.11 11.73 6 85691 21 34871213
Acute respiratory failure 21.09 11.73 139 85558 30789 34840445
Full blood count decreased 21.00 11.73 9 85688 18079 34853155
Haemorrhagic pneumonia 20.99 11.73 9 85688 127 34871107
Enterococcal sepsis 20.77 11.73 23 85674 1649 34869585
Urinary tract infection 20.71 11.73 121 85576 83960 34787274
Vestibular disorder 20.69 11.73 19 85678 1088 34870146
Gastrointestinal disorder 20.65 11.73 32 85665 33916 34837318
Encephalomalacia 20.63 11.73 17 85680 841 34870393
Multiple-drug resistance 20.61 11.73 42 85655 5197 34866037
Serotonin syndrome 20.49 11.73 100 85597 19833 34851401
Hepatitis 20.48 11.73 114 85583 23790 34847444
Hepatomegaly 20.42 11.73 64 85633 10332 34860902
Metastases to bone marrow 20.39 11.73 14 85683 524 34870710
Endocarditis staphylococcal 20.28 11.73 13 85684 433 34870801
Tachypnoea 20.27 11.73 94 85603 18258 34852976
Posterior reversible encephalopathy syndrome 20.22 11.73 62 85635 9892 34861342
Allergy test positive 20.21 11.73 8 85689 91 34871143
Skin test positive 20.20 11.73 12 85685 348 34870886
Intentional product use issue 20.07 11.73 77 85620 59739 34811495
Vanishing bile duct syndrome 20.06 11.73 18 85679 1000 34870234
Drug trough level 20.05 11.73 4 85693 0 34871234
Bone pain 20.02 11.73 13 85684 20673 34850561
Abnormal behaviour 19.99 11.73 19 85678 24950 34846284
Liver disorder 19.96 11.73 144 85553 32853 34838381
Cryptococcosis 19.86 11.73 27 85670 2392 34868842
Abdominal pain 19.84 11.73 282 85415 163336 34707898
Vertigo 19.79 11.73 20 85677 25516 34845718
Myoclonus 19.77 11.73 80 85617 14645 34856589
Skin exfoliation 19.76 11.73 125 85572 27307 34843927
Drug level below therapeutic 19.75 11.73 43 85654 5572 34865662
Lung neoplasm malignant 19.65 11.73 9 85688 17386 34853848
Bacterial sepsis 19.38 11.73 41 85656 5209 34866025
General physical health deterioration 19.33 11.73 211 85486 128058 34743176
Upper respiratory tract infection 19.32 11.73 32 85665 33027 34838207
Brain herniation 19.29 11.73 35 85662 3973 34867261
Product preparation error 19.23 11.73 26 85671 2291 34868943
Jarisch-Herxheimer reaction 19.21 11.73 14 85683 577 34870657
Bacterial pericarditis 18.94 11.73 7 85690 65 34871169
Benign prostatic hyperplasia 18.87 11.73 6 85691 14489 34856745
Contraindicated product administered 18.83 11.73 15 85682 21466 34849768
Paraesthesia 18.81 11.73 87 85610 64085 34807149
Angina unstable 18.81 11.73 3 85694 11650 34859584
Intervertebral discitis 18.78 11.73 25 85672 2170 34869064
Fixed eruption 18.77 11.73 22 85675 1678 34869556
Endocarditis bacterial 18.74 11.73 17 85680 958 34870276
Metastases to muscle 18.73 11.73 10 85687 235 34870999
Angina pectoris 18.67 11.73 30 85667 31333 34839901
Cardiovascular somatic symptom disorder 18.64 11.73 6 85691 35 34871199
Musculoskeletal pain 18.62 11.73 31 85666 31932 34839302
Renal tubular injury 18.62 11.73 17 85680 966 34870268
Corynebacterium infection 18.51 11.73 14 85683 611 34870623
Pseudomonas test positive 18.47 11.73 18 85679 1111 34870123
Febrile bone marrow aplasia 18.45 11.73 53 85644 8156 34863078
Irritability 18.39 11.73 20 85677 24670 34846564
Clostridium colitis 18.37 11.73 19 85678 1260 34869974
Metastases to retroperitoneum 18.31 11.73 10 85687 246 34870988
Heart rate decreased 18.30 11.73 31 85666 31714 34839520
Large intestinal ulcer haemorrhage 18.28 11.73 8 85689 119 34871115
Blood pressure fluctuation 18.21 11.73 21 85676 25228 34846006
Glycosylated haemoglobin increased 18.17 11.73 3 85694 11357 34859877
Fusarium infection 18.06 11.73 18 85679 1142 34870092
Disseminated mucormycosis 18.02 11.73 13 85684 527 34870707
Vascular purpura 17.98 11.73 22 85675 1756 34869478
Janeway lesion 17.93 11.73 5 85692 16 34871218
Multiple sclerosis relapse 17.89 11.73 5 85692 13128 34858106
Glomerular filtration rate decreased 17.87 11.73 71 85626 12890 34858344
Toxic shock syndrome staphylococcal 17.82 11.73 4 85693 3 34871231
Wrong rate 17.82 11.73 4 85693 3 34871231
Vitamin K deficiency 17.82 11.73 10 85687 260 34870974
Blood pressure systolic increased 17.76 11.73 18 85679 22934 34848300
Product prescribing error 17.72 11.73 18 85679 22909 34848325
Osteonecrosis of jaw 17.65 11.73 11 85686 17878 34853356
Strongyloidiasis 17.50 11.73 27 85670 2684 34868550
Urinary tract infection fungal 17.48 11.73 12 85685 449 34870785
Meningitis eosinophilic 17.48 11.73 5 85692 18 34871216
Platelet dysfunction 17.41 11.73 10 85687 272 34870962
Intentional self-injury 17.40 11.73 6 85691 13765 34857469
Coronary artery occlusion 17.30 11.73 3 85694 10959 34860275
Gastritis fungal 17.27 11.73 7 85690 85 34871149
Disseminated sporotrichosis 17.27 11.73 5 85692 19 34871215
Alanine aminotransferase increased 17.16 11.73 286 85411 80529 34790705
Nocardiosis 17.14 11.73 33 85664 3918 34867316
Diplopia 17.12 11.73 10 85687 16833 34854401
Antinuclear antibody negative 17.07 11.73 5 85692 20 34871214
Acinetobacter test positive 17.06 11.73 8 85689 141 34871093
ADAMTS13 activity decreased 17.06 11.73 7 85690 88 34871146
Palmar-plantar erythrodysaesthesia syndrome 17.03 11.73 10 85687 16785 34854449
Pruritus 16.97 11.73 462 85235 141519 34729715
Sudden death 16.96 11.73 8 85689 15193 34856041
Extravasation 16.91 11.73 22 85675 1868 34869366
Road traffic accident 16.85 11.73 11 85686 17439 34853795
Arthritis 16.82 11.73 32 85665 31314 34839920
Head injury 16.79 11.73 12 85685 18148 34853086
Liver transplant failure 16.78 11.73 7 85690 92 34871142
Tremor 16.74 11.73 126 85571 82461 34788773
Hepatic failure 16.65 11.73 143 85554 34388 34836846
Intestinal obstruction 16.44 11.73 19 85678 22803 34848431
Hypersomnia 16.39 11.73 5 85692 12402 34858832
Toxic shock syndrome 16.38 11.73 11 85686 397 34870837
Liver abscess 16.25 11.73 32 85665 3863 34867371
Orthostatic hypotension 16.18 11.73 24 85673 25895 34845339
Symptom masked 16.11 11.73 13 85684 624 34870610
Obstructive airways disorder 16.03 11.73 9 85688 15485 34855749
Rash pruritic 15.96 11.73 117 85580 26824 34844410
Red blood cell sedimentation rate decreased 15.84 11.73 6 85691 60 34871174
Oedema peripheral 15.78 11.73 203 85494 119609 34751625
Incorrect dose administered 15.72 11.73 49 85648 40466 34830768
Pneumonia mycoplasmal 15.71 11.73 13 85684 647 34870587
Bone marrow failure 15.63 11.73 124 85573 29129 34842105
Soft tissue necrosis 15.63 11.73 10 85687 332 34870902
Wrong product administered 15.62 11.73 38 85659 5296 34865938
Nutritional condition abnormal 15.51 11.73 11 85686 434 34870800
Blood alkaline phosphatase increased 15.50 11.73 130 85567 31045 34840189
Infective thrombosis 15.50 11.73 6 85691 64 34871170
Rib fracture 15.43 11.73 8 85689 14392 34856842
Unresponsive to stimuli 15.36 11.73 118 85579 27451 34843783
Anger 15.33 11.73 5 85692 11879 34859355
Diabetic ketoacidosis 15.30 11.73 13 85684 18019 34853215
Dysphonia 15.24 11.73 21 85676 23362 34847872
Oropharyngeal pain 15.16 11.73 41 85656 35444 34835790
Mucosal inflammation 15.13 11.73 153 85544 38469 34832765
Diverticulitis 15.13 11.73 16 85681 19988 34851246
Neoplasm progression 15.11 11.73 21 85676 23279 34847955
Arthrofibrosis 15.10 11.73 6 85691 69 34871165
Hyperhidrosis 15.09 11.73 116 85581 75576 34795658
Asthma late onset 15.04 11.73 3 85694 0 34871234
Haemorrhagic vasculitis 15.04 11.73 3 85694 0 34871234
Mycobacterial peritonitis 15.04 11.73 3 85694 0 34871234
Prothrombin time prolonged 15.02 11.73 54 85643 9352 34861882
Respiratory gas exchange disorder 14.93 11.73 11 85686 461 34870773
Osteonecrosis 14.91 11.73 9 85688 14881 34856353
Rectal perforation 14.76 11.73 11 85686 469 34870765
Continuous haemodiafiltration 14.72 11.73 15 85682 977 34870257
Injection site haemorrhage 14.72 11.73 3 85694 9765 34861469
Meningitis 14.70 11.73 35 85662 4812 34866422
Expired product administered 14.61 11.73 28 85669 3313 34867921
Pulse absent 14.56 11.73 39 85658 5764 34865470
Sputum purulent 14.44 11.73 11 85686 485 34870749
Amnesia 14.36 11.73 27 85670 26536 34844698
Streptococcal bacteraemia 14.33 11.73 21 85676 1994 34869240
Injection site reaction 14.33 11.73 7 85690 13026 34858208
Interleukin-2 receptor increased 14.31 11.73 7 85690 136 34871098
Dry eye 14.30 11.73 3 85694 9572 34861662
Target skin lesion 14.30 11.73 4 85693 13 34871221
Hyperlipidaemia 14.24 11.73 9 85688 14520 34856714
Abscess 14.15 11.73 62 85635 11755 34859479
Citrobacter infection 14.11 11.73 11 85686 502 34870732
Adverse drug reaction 14.02 11.73 32 85665 29310 34841924
Abdominal distension 13.96 11.73 85 85612 58407 34812827
Swelling 13.91 11.73 55 85642 42311 34828923
Bacterial toxaemia 13.86 11.73 7 85690 146 34871088
Periostosis 13.86 11.73 4 85693 15 34871219
Visual acuity reduced 13.82 11.73 77 85620 16072 34855162
Herpes zoster 13.77 11.73 41 85656 34358 34836876
Neonatal cholestasis 13.76 11.73 5 85692 44 34871190
Ear infection 13.74 11.73 4 85693 10227 34861007
Deafness neurosensory 13.73 11.73 25 85672 2846 34868388
Oesophageal carcinoma 13.73 11.73 3 85694 9301 34861933
Nocturia 13.70 11.73 4 85693 10206 34861028
Pneumonia klebsiella 13.63 11.73 27 85670 3273 34867961
Gastric ulcer 13.63 11.73 11 85686 15639 34855595
Wound dehiscence 13.57 11.73 27 85670 3284 34867950
Leukoerythroblastosis 13.57 11.73 5 85692 46 34871188
Aortic pseudoaneurysm 13.57 11.73 5 85692 46 34871188
Interstitial lung disease 13.51 11.73 99 85598 65183 34806051
Pericarditis fungal 13.48 11.73 7 85690 155 34871079
Hypothyroidism 13.40 11.73 19 85678 20883 34850351
Acute myocardial infarction 13.39 11.73 77 85620 53642 34817592
Urticaria 13.33 11.73 221 85476 62156 34809078
Red blood cell schistocytes present 13.32 11.73 8 85689 237 34870997
Tooth disorder 13.31 11.73 5 85692 10877 34860357
Hyponatraemia 13.27 11.73 134 85563 82557 34788677
Pneumonia bacterial 13.25 11.73 61 85636 11811 34859423
Activated partial thromboplastin time prolonged 13.11 11.73 49 85648 8646 34862588
Intra-abdominal fluid collection 13.09 11.73 16 85681 1275 34869959
Palpable purpura 13.09 11.73 7 85690 165 34871069
Type 2 diabetes mellitus 13.07 11.73 12 85685 16020 34855214
Enterocolitis haemorrhagic 13.04 11.73 14 85683 969 34870265
Aspartate aminotransferase increased 12.99 11.73 236 85461 67547 34803687
Anaphylactic shock 12.98 11.73 75 85622 15866 34855368
Ependymitis 12.97 11.73 3 85694 3 34871231
Meningitis bacterial 12.94 11.73 16 85681 1291 34869943
Plasma cell myeloma 12.91 11.73 56 85641 41981 34829253
Suspected transmission of an infectious agent via product 12.91 11.73 13 85684 835 34870399
Pancreatic carcinoma 12.87 11.73 3 85694 8898 34862336
Complication of device removal 12.86 11.73 5 85692 54 34871180
Bronchiectasis 12.86 11.73 4 85693 9797 34861437
Therapeutic product effect prolonged 12.85 11.73 8 85689 253 34870981
Empyema 12.80 11.73 26 85671 3210 34868024
Progressive multifocal leukoencephalopathy 12.78 11.73 4 85693 9760 34861474
Metastases to spleen 12.78 11.73 10 85687 459 34870775
Gastrointestinal fungal infection 12.75 11.73 7 85690 174 34871060
Heart rate irregular 12.69 11.73 12 85685 15795 34855439
Meningitis fungal 12.63 11.73 6 85691 109 34871125
Type I hypersensitivity 12.63 11.73 16 85681 1323 34869911
Haematemesis 12.62 11.73 31 85666 27680 34843554
Obesity 12.59 11.73 8 85689 12870 34858364
Abscess bacterial 12.58 11.73 7 85690 179 34871055
Hypogonadism 12.56 11.73 21 85676 2234 34869000
Macule 12.56 11.73 17 85680 1500 34869734
Arthritis bacterial 12.49 11.73 34 85663 5072 34866162
Mediastinal abscess 12.47 11.73 5 85692 59 34871175
Acute coronary syndrome 12.46 11.73 9 85688 13536 34857698
Hernia 12.41 11.73 4 85693 9579 34861655
Pemphigoid 12.37 11.73 3 85694 8663 34862571
Brain death 12.37 11.73 23 85674 2660 34868574
Periorbital oedema 12.32 11.73 28 85669 3734 34867500
Ischaemic stroke 12.29 11.73 16 85681 18234 34853000
Colon cancer 12.28 11.73 3 85694 8618 34862616
Mania 12.27 11.73 4 85693 9507 34861727
Gastrointestinal mucormycosis 12.27 11.73 7 85690 188 34871046
Tetanus 12.24 11.73 5 85692 62 34871172
Cutaneous mucormycosis 12.23 11.73 7 85690 189 34871045
Osteoporosis 12.21 11.73 8 85689 12660 34858574
Hallucination 12.21 11.73 75 85622 51423 34819811
Delusion 12.15 11.73 8 85689 12627 34858607
Anaphylactoid reaction 12.09 11.73 21 85676 2304 34868930
Acne 12.08 11.73 6 85691 11060 34860174
Visual impairment 12.06 11.73 46 85651 35756 34835478
White blood cell count increased 12.04 11.73 154 85543 40997 34830237
Potentiating drug interaction 12.04 11.73 33 85664 4944 34866290
Pulseless electrical activity 12.03 11.73 42 85655 7169 34864065
Pleural effusion 12.01 11.73 273 85424 81273 34789961
Myocardial ischaemia 12.00 11.73 15 85682 17393 34853841
Necrosis 11.96 11.73 36 85661 5687 34865547
Mast cell degranulation present 11.83 11.73 5 85692 68 34871166
Limb injury 11.79 11.73 7 85690 11682 34859552
Meningism 11.78 11.73 7 85690 203 34871031
Corynebacterium sepsis 11.76 11.73 3 85694 6 34871228
Product substitution issue 11.75 11.73 5 85692 10090 34861144

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 3907.40 11.18 2039 144012 62205 79536132
Acute kidney injury 2558.32 11.18 3882 142169 515522 79082815
Linear IgA disease 1771.82 11.18 507 145544 2625 79595712
Renal tubular necrosis 1112.57 11.18 647 145404 24392 79573945
Multiple organ dysfunction syndrome 1015.73 11.18 1175 144876 119071 79479266
Eosinophilia 936.87 11.18 728 145323 44617 79553720
Septic shock 846.69 11.18 1083 144968 121718 79476619
Nephropathy toxic 692.52 11.18 444 145607 19975 79578362
Fatigue 690.76 11.18 427 145624 929300 78669037
Toxic epidermal necrolysis 679.27 11.18 600 145451 43981 79554356
Rash maculo-papular 609.13 11.18 626 145425 55452 79542885
Pathogen resistance 598.59 11.18 356 145695 13986 79584351
Acute generalised exanthematous pustulosis 587.14 11.18 376 145675 16878 79581459
Tubulointerstitial nephritis 541.75 11.18 494 145557 37741 79560596
Pyrexia 506.70 11.18 2516 143535 676193 78922144
Drug resistance 489.01 11.18 488 145563 41725 79556612
Sepsis 467.72 11.18 1313 144738 268115 79330222
Renal failure 446.98 11.18 1075 144976 199893 79398444
Arthralgia 434.18 11.18 255 145796 571548 79026789
Antibiotic level above therapeutic 432.91 11.18 123 145928 617 79597720
Clostridium difficile infection 404.06 11.18 443 145608 42242 79556095
Renal impairment 387.89 11.18 878 145173 156905 79441432
Retinal vasculitis 387.34 11.18 130 145921 1223 79597114
Drug ineffective 374.61 11.18 3305 142746 1077608 78520729
Respiratory failure 372.79 11.18 940 145111 179971 79418366
Dizziness 366.44 11.18 259 145792 526182 79072155
Staphylococcal infection 359.34 11.18 487 145564 57808 79540529
Enterococcal infection 346.44 11.18 262 145789 15398 79582939
Headache 344.75 11.18 415 145636 653357 78944980
Fall 341.83 11.18 238 145813 487391 79110946
Joint swelling 330.26 11.18 64 145987 288582 79309755
Blood creatinine increased 330.24 11.18 816 145235 154241 79444096
Drug level increased 328.47 11.18 384 145667 39267 79559070
Rash morbilliform 289.27 11.18 165 145886 5985 79592352
Toxic skin eruption 281.05 11.18 270 145781 22023 79576314
Clostridium difficile colitis 279.73 11.18 320 145731 31963 79566374
Thrombocytopenia 276.28 11.18 1088 144963 264171 79334166
Arthropathy 269.89 11.18 13 146038 177098 79421239
Rheumatoid arthritis 265.99 11.18 34 146017 208436 79389901
Nausea 265.76 11.18 885 145166 956311 78642026
Stevens-Johnson syndrome 265.71 11.18 343 145708 38823 79559514
Drug ineffective for unapproved indication 262.57 11.18 392 145659 50846 79547491
Drug abuse 257.76 11.18 9 146042 162682 79435655
Product dose omission issue 256.86 11.18 68 145983 247469 79350868
Renal injury 256.07 11.18 227 145824 16700 79581637
Haemophagocytic lymphohistiocytosis 250.16 11.18 251 145800 21586 79576751
Alopecia 243.01 11.18 62 145989 231293 79367044
Abdominal discomfort 239.90 11.18 80 145971 250647 79347690
Synovitis 236.50 11.18 9 146042 150725 79447612
Pain 231.83 11.18 600 145451 703202 78895135
Pain in extremity 224.90 11.18 202 145849 364336 79234001
Pancytopenia 223.61 11.18 740 145311 165005 79433332
Nasopharyngitis 217.99 11.18 96 145955 253785 79344552
Peripheral swelling 216.13 11.18 112 145939 269505 79328832
Antimicrobial susceptibility test resistant 211.33 11.18 61 145990 327 79598010
Contraindicated product administered 210.15 11.18 22 146029 157516 79440821
Drug hypersensitivity 209.79 11.18 1091 144960 297825 79300512
Acute respiratory distress syndrome 205.85 11.18 323 145728 43744 79554593
Disseminated intravascular coagulation 202.20 11.18 287 145764 35555 79562782
Insomnia 191.86 11.18 105 145946 245065 79353272
Bacteraemia 189.86 11.18 266 145785 32558 79565779
Staphylococcal bacteraemia 185.11 11.18 164 145887 12054 79586283
Pseudomembranous colitis 184.99 11.18 118 145933 5256 79593081
Drug intolerance 184.66 11.18 129 145922 263990 79334347
Encephalopathy 183.50 11.18 391 145660 67006 79531331
Klebsiella infection 182.47 11.18 182 145869 15538 79582799
Therapeutic product effect decreased 177.73 11.18 41 146010 163822 79434515
Shock 174.72 11.18 298 145753 43250 79555087
Constipation 174.31 11.18 157 145894 282893 79315444
Candida infection 174.20 11.18 277 145774 37937 79560400
Malaise 171.69 11.18 404 145647 489465 79108872
Musculoskeletal stiffness 170.60 11.18 54 145997 174954 79423383
Swelling 169.27 11.18 93 145958 216618 79381719
Weight increased 168.27 11.18 156 145895 277230 79321107
Endocarditis 164.05 11.18 144 145907 10453 79587884
Glossodynia 159.29 11.18 7 146044 103330 79495007
Gait disturbance 159.25 11.18 91 145960 207415 79390922
Haemodialysis 158.91 11.18 181 145870 17987 79580350
Leukocytosis 158.29 11.18 285 145766 43170 79555167
Choroiditis 155.09 11.18 67 145984 1314 79597023
Muscle spasms 153.23 11.18 64 145987 174666 79423671
Injection site pain 152.21 11.18 27 146024 129811 79468526
Systemic candida 150.09 11.18 113 145938 6593 79591744
Asthenia 149.88 11.18 461 145590 511228 79087109
Aplastic anaemia 149.24 11.18 174 145877 17731 79580606
Agranulocytosis 144.86 11.18 280 145771 44750 79553587
Leukopenia 144.57 11.18 506 145545 116007 79482330
Anaphylactic reaction 143.80 11.18 407 145644 83336 79515001
Weight decreased 143.61 11.18 270 145781 354928 79243409
Febrile neutropenia 142.95 11.18 815 145236 230184 79368153
Abdominal pain upper 141.57 11.18 121 145930 223698 79374639
Hypotension 139.28 11.18 1323 144728 438994 79159343
Sinusitis 138.58 11.18 94 145957 195407 79402930
Feeling abnormal 138.49 11.18 59 145992 159140 79439197
Haemodynamic instability 138.38 11.18 165 145886 17217 79581120
Fungaemia 136.55 11.18 92 145959 4499 79593838
Rash erythematous 134.62 11.18 315 145736 57454 79540883
Drug eruption 133.83 11.18 267 145784 43668 79554669
Pseudomonas infection 132.36 11.18 177 145874 20726 79577611
Dermatitis exfoliative 130.55 11.18 128 145923 10701 79587636
Hypoxia 130.36 11.18 451 145600 102792 79495545
Device related infection 130.14 11.18 229 145822 34065 79564272
Decreased appetite 130.03 11.18 270 145781 342148 79256189
Neurotoxicity 129.74 11.18 222 145829 32296 79566041
Intentional overdose 128.72 11.18 20 146031 105940 79492397
Cytokine release syndrome 128.44 11.18 234 145817 35764 79562573
Cholestasis 127.88 11.18 290 145761 51819 79546518
Aspergillus infection 125.56 11.18 165 145886 18996 79579341
Acinetobacter infection 123.91 11.18 72 145979 2705 79595632
Hypoaesthesia 122.16 11.18 90 145961 179262 79419075
Device related sepsis 121.90 11.18 97 145954 6143 79592194
Mucormycosis 121.03 11.18 110 145941 8359 79589978
Ototoxicity 117.97 11.18 74 145977 3200 79595137
Psoriatic arthropathy 117.90 11.18 6 146045 77993 79520344
Contusion 115.92 11.18 64 145987 148712 79449625
Rash 115.22 11.18 1588 144463 576770 79021567
Fear 115.17 11.18 170 145881 21816 79576521
Back pain 114.50 11.18 241 145810 303939 79294398
Bronchopulmonary aspergillosis 113.37 11.18 170 145881 22124 79576213
Memory impairment 113.37 11.18 32 146019 111702 79486635
Mobility decreased 111.61 11.18 42 146009 122133 79476204
Dry mouth 110.66 11.18 15 146036 88004 79510333
Discomfort 110.14 11.18 46 146005 125571 79472766
Systemic lupus erythematosus 110.09 11.18 42 146009 121107 79477230
Suicide attempt 109.50 11.18 12 146039 82920 79515417
Anhedonia 108.18 11.18 135 145916 14763 79583574
Drug level above therapeutic 106.83 11.18 104 145947 8619 79589718
Antibiotic level below therapeutic 106.63 11.18 26 146025 61 79598276
Dyspnoea 105.87 11.18 1032 145019 855993 78742344
Transaminases increased 105.47 11.18 268 145783 51475 79546862
Neutropenia 105.46 11.18 893 145158 286817 79311520
Helicobacter infection 103.37 11.18 6 146045 69698 79528639
Endophthalmitis 102.83 11.18 89 145962 6339 79591998
Off label use 102.41 11.18 2274 143777 904941 78693396
Geotrichum infection 101.74 11.18 45 146006 936 79597401
Oliguria 101.58 11.18 137 145914 16172 79582165
Dysbiosis 101.51 11.18 48 146003 1171 79597166
Wound 101.12 11.18 43 146008 116136 79482201
Haemorrhagic vasculitis 101.04 11.18 26 146025 82 79598255
Arthritis 100.82 11.18 42 146009 114838 79483499
Blood cholesterol increased 99.01 11.18 17 146034 83703 79514634
Respiratory distress 97.67 11.18 281 145770 58058 79540279
Mental status changes 97.47 11.18 307 145744 66652 79531685
Depression 95.51 11.18 156 145895 216634 79381703
Face oedema 95.48 11.18 179 145872 27957 79570380
Erythema 95.42 11.18 718 145333 222572 79375765
Gastrooesophageal reflux disease 94.95 11.18 36 146015 104210 79494127
Trichosporon infection 94.22 11.18 43 146008 965 79597372
Bronchitis 93.65 11.18 62 145989 130582 79467755
Immune effector cell-associated neurotoxicity syndrome 93.61 11.18 81 145970 5767 79592570
Stenotrophomonas infection 92.13 11.18 67 145984 3706 79594631
Psoriasis 92.11 11.18 25 146026 89562 79508775
Nephropathy 91.99 11.18 101 145950 9637 79588700
Septic embolus 88.41 11.18 52 145999 1999 79596338
Immune thrombocytopenia 88.02 11.18 134 145917 17671 79580666
Megacolon 87.47 11.18 63 145988 3432 79594905
Systemic inflammatory response syndrome 86.64 11.18 106 145945 11359 79586978
Dermatitis exfoliative generalised 86.19 11.18 85 145966 7156 79591181
Dialysis 85.75 11.18 135 145916 18327 79580010
Fibromyalgia 85.73 11.18 9 146042 64331 79534006
Tachycardia 85.39 11.18 588 145463 177180 79421157
Myeloma cast nephropathy 85.10 11.18 25 146026 144 79598193
Bacterial disease carrier 85.08 11.18 46 146005 1500 79596837
Vomiting 84.96 11.18 795 145256 665033 78933304
Dermatitis bullous 84.69 11.18 117 145934 14128 79584209
Death 83.17 11.18 652 145399 565862 79032475
Graft versus host disease 82.79 11.18 119 145932 14907 79583430
Henoch-Schonlein purpura 82.26 11.18 55 145996 2655 79595682
Balance disorder 82.25 11.18 39 146012 98818 79499519
Cough 79.63 11.18 373 145678 366416 79231921
Minimum inhibitory concentration 79.24 11.18 24 146027 156 79598181
Cardiac valve vegetation 79.03 11.18 37 146014 882 79597455
Blood culture positive 78.89 11.18 87 145964 8342 79589995
Type IV hypersensitivity reaction 78.78 11.18 63 145988 4018 79594319
Enterococcal bacteraemia 78.38 11.18 56 145995 3012 79595325
Musculoskeletal pain 78.32 11.18 45 146006 102309 79496028
Sleep disorder 77.34 11.18 30 146021 85647 79512690
Dyspepsia 77.33 11.18 52 145999 108635 79489702
Cardiac arrest 77.26 11.18 560 145491 171536 79426801
Muscular weakness 77.20 11.18 109 145942 160620 79437717
Kounis syndrome 76.12 11.18 63 145988 4219 79594118
Metabolic acidosis 75.06 11.18 325 145726 82204 79516133
Osteoarthritis 74.88 11.18 33 146018 87276 79511061
Noninfectious peritonitis 74.78 11.18 25 146026 232 79598105
Pericarditis 73.99 11.18 50 146001 104186 79494151
Hypertension 73.37 11.18 334 145717 330658 79267679
Irritable bowel syndrome 72.80 11.18 13 146038 62228 79536109
Erythema multiforme 72.38 11.18 122 145929 17529 79580808
Heparin-induced thrombocytopenia 72.33 11.18 89 145962 9593 79588744
Purpura 72.29 11.18 129 145922 19398 79578939
Syncope 71.90 11.18 137 145914 179312 79419025
Clostridium test positive 71.74 11.18 73 145978 6381 79591956
Staphylococcal sepsis 71.63 11.18 110 145941 14616 79583721
Staphylococcus test positive 69.67 11.18 72 145979 6409 79591928
Enterococcus test positive 69.46 11.18 45 146006 2059 79596278
Superinfection 68.74 11.18 63 145988 4839 79593498
Migraine 67.61 11.18 38 146013 87455 79510882
Chest pain 67.36 11.18 277 145774 282027 79316310
Blood pressure increased 67.14 11.18 183 145868 211177 79387160
Chest discomfort 66.90 11.18 93 145958 137951 79460386
Suicidal ideation 66.83 11.18 28 146023 76312 79522025
Injection site erythema 66.37 11.18 30 146021 78167 79520170
Myocardial infarction 65.83 11.18 150 145901 183979 79414358
Drug dispensed to wrong patient 65.62 11.18 30 146021 676 79597661
Escherichia infection 65.38 11.18 118 145933 17899 79580438
Cross sensitivity reaction 64.71 11.18 54 145997 3658 79594679
Injection site reaction 62.88 11.18 12 146039 54773 79543564
Brain abscess 62.61 11.18 60 145991 4876 79593461
Fungal sepsis 62.53 11.18 40 146011 1790 79596547
Diarrhoea 62.51 11.18 1187 144864 879302 78719035
Product contamination 62.48 11.18 35 146016 1225 79597112
Vascular device infection 61.99 11.18 85 145966 10191 79588146
Intentional product misuse 61.91 11.18 50 146001 95115 79503222
Hepatocellular injury 61.87 11.18 210 145841 47383 79550954
Injection site swelling 61.76 11.18 7 146044 47125 79551212
Generalised oedema 61.58 11.18 135 145916 23574 79574763
Haemorrhagic occlusive retinal vasculitis 60.98 11.18 12 146039 3 79598334
Pulmonary haemorrhage 60.72 11.18 102 145949 14615 79583722
Bronchospasm 60.59 11.18 138 145913 24721 79573616
Gait inability 59.52 11.18 17 146034 58900 79539437
Vision blurred 59.05 11.18 64 145987 105834 79492503
Eosinophilic pneumonia 58.91 11.18 60 145991 5250 79593087
Paraesthesia 58.79 11.18 149 145902 176174 79422163
Venoocclusive liver disease 58.76 11.18 89 145962 11682 79586655
Anuria 58.63 11.18 123 145928 20840 79577497
Upper respiratory tract infection 57.95 11.18 49 146002 91119 79507218
Crystal nephropathy 57.80 11.18 35 146016 1420 79596917
Hepatic function abnormal 57.61 11.18 276 145775 72831 79525506
Dyspnoea exertional 57.58 11.18 45 146006 87028 79511309
Cognitive disorder 57.53 11.18 28 146023 69898 79528439
Transient ischaemic attack 57.47 11.18 13 146038 52682 79545655
Toxic anterior segment syndrome 56.21 11.18 44 146007 2720 79595617
Acute respiratory failure 56.08 11.18 237 145814 59304 79539033
Blood bilirubin increased 55.82 11.18 255 145796 65977 79532360
Gastrointestinal disorder 54.67 11.18 87 145964 122118 79476219
Hypoalbuminaemia 53.88 11.18 120 145931 21177 79577160
Clostridial infection 53.51 11.18 59 145992 5655 79592682
Fungal peritonitis 53.04 11.18 30 146021 1070 79597267
Nephritis 53.03 11.18 51 146000 4163 79594174
Nervous system disorder 52.55 11.18 137 145914 26719 79571618
Folliculitis 52.33 11.18 18 146033 55362 79542975
Bronchial secretion retention 52.27 11.18 50 146001 4054 79594283
Blood urea increased 52.16 11.18 202 145849 48588 79549749
Ill-defined disorder 51.78 11.18 28 146023 65847 79532490
Herpes simplex oesophagitis 51.41 11.18 21 146030 356 79597981
Depressed mood 50.83 11.18 13 146038 48467 79549870
C-reactive protein abnormal 50.66 11.18 13 146038 48354 79549983
Somnolence 50.66 11.18 245 145806 238736 79359601
Osteonecrosis of jaw 50.62 11.18 9 146042 43217 79555120
Pleural effusion 50.58 11.18 446 145605 144816 79453521
Wrong technique in product usage process 50.36 11.18 37 146014 73838 79524499
Hyperbilirubinaemia 49.96 11.18 127 145924 24391 79573946
Emotional distress 49.89 11.18 174 145877 39795 79558542
Unevaluable event 49.85 11.18 218 145833 55367 79542970
Neck pain 49.84 11.18 39 146012 75378 79522959
Cutaneous vasculitis 49.39 11.18 68 145983 8184 79590153
Skin exfoliation 49.34 11.18 216 145835 54884 79543453
Blood alkaline phosphatase increased 49.19 11.18 239 145812 63425 79534912
Fluid retention 48.85 11.18 34 146017 69775 79528562
Blood glucose increased 48.52 11.18 85 145966 114890 79483447
Cataract 47.96 11.18 27 146024 62093 79536244
Multiple sclerosis relapse 47.80 11.18 13 146038 46520 79551817
Dry skin 47.74 11.18 33 146018 67962 79530375
Hip arthroplasty 47.64 11.18 5 146046 35751 79562586
Nasal congestion 47.61 11.18 42 146009 76510 79521827
Myalgia 47.55 11.18 177 145874 185464 79412873
Posterior reversible encephalopathy syndrome 47.32 11.18 130 145921 26151 79572186
Rash macular 47.20 11.18 138 145913 28761 79569576
Pneumonia staphylococcal 46.82 11.18 51 146000 4823 79593514
Therapeutic response delayed 46.73 11.18 28 146023 1114 79597223
Hot flush 46.65 11.18 21 146030 54856 79543481
Sleep apnoea syndrome 46.36 11.18 6 146045 36472 79561865
Drug level below therapeutic 46.14 11.18 72 145979 9698 79588639
Enterobacter infection 46.04 11.18 49 146002 4513 79593824
Multiple-drug resistance 45.97 11.18 68 145983 8740 79589597
Rhinorrhoea 45.81 11.18 43 146008 76031 79522306
Alanine aminotransferase increased 45.66 11.18 477 145574 162093 79436244
Pneumonia fungal 45.33 11.18 77 145974 11133 79587204
Vertigo 45.30 11.18 36 146015 69046 79529291
Coagulopathy 45.16 11.18 157 145894 35849 79562488
Drug dependence 44.58 11.18 10 146041 40759 79557578
Knee arthroplasty 44.58 11.18 12 146039 43236 79555101
Petechiae 44.51 11.18 109 145942 20456 79577881
Acidosis 44.11 11.18 106 145945 19656 79578681
Eosinophil count increased 43.97 11.18 97 145954 17008 79581329
Incorrect drug administration rate 43.77 11.18 45 146006 3981 79594356
Intentional product use issue 43.72 11.18 138 145913 151974 79446363
Impaired healing 43.53 11.18 58 145993 87597 79510740
Asthma 42.86 11.18 117 145934 134978 79463359
Blood pressure fluctuation 42.78 11.18 36 146015 67109 79531228
Hepatosplenic candidiasis 42.46 11.18 21 146030 567 79597770
Type 2 diabetes mellitus 42.44 11.18 26 146025 57096 79541241
Loss of personal independence in daily activities 42.24 11.18 77 145974 102503 79495834
Coronary artery disease 41.84 11.18 35 146016 65439 79532898
Inappropriate schedule of product administration 41.45 11.18 117 145934 133511 79464826
Prothrombin time prolonged 41.39 11.18 94 145957 16805 79581532
Influenza 41.30 11.18 112 145939 129494 79468843
Disseminated cryptococcosis 41.26 11.18 31 146020 1803 79596534
Tachypnoea 41.25 11.18 141 145910 31922 79566415
Prostate cancer 41.03 11.18 6 146045 33262 79565075
Procalcitonin increased 40.92 11.18 38 146013 2968 79595369
Venoocclusive disease 40.73 11.18 46 146005 4527 79593810
Thrombotic microangiopathy 40.61 11.18 104 145947 20065 79578272
Blood pressure systolic increased 40.17 11.18 38 146013 66948 79531389
Eosinophilic pneumonia acute 40.02 11.18 25 146026 1073 79597264
Osteoporosis 39.69 11.18 25 146026 54087 79544250
Platelet count decreased 39.59 11.18 537 145514 194127 79404210
Human herpesvirus 6 infection 39.53 11.18 49 146002 5321 79593016
Hypernatraemia 39.49 11.18 84 145967 14367 79583970
Anaphylactic shock 39.27 11.18 150 145901 35846 79562491
Basal cell carcinoma 39.23 11.18 10 146041 37365 79560972
Haemolytic anaemia 39.15 11.18 95 145956 17725 79580612
Device related bacteraemia 38.95 11.18 21 146030 681 79597656
Nosocomial infection 38.94 11.18 36 146015 2796 79595541
Factor V deficiency 38.86 11.18 12 146039 84 79598253
Bursitis 38.78 11.18 9 146042 35835 79562502
Sciatica 38.72 11.18 7 146044 33215 79565122
Neuropathy peripheral 38.66 11.18 131 145920 141174 79457163
Hyperthermia 38.40 11.18 95 145956 17942 79580395
Organ failure 38.39 11.18 42 146009 3991 79594346
Renal tubular disorder 38.15 11.18 53 145998 6433 79591904
Retinal haemorrhage 38.04 11.18 60 145991 8157 79590180
Lower respiratory tract infection 38.00 11.18 116 145935 129104 79469233
Myeloid maturation arrest 37.85 11.18 10 146041 36 79598301
Injection site pruritus 37.83 11.18 15 146036 42268 79556069
Serotonin syndrome 37.67 11.18 173 145878 44854 79553483
Cardiac failure congestive 37.63 11.18 134 145917 142268 79456069
Injection site bruising 37.59 11.18 14 146037 40988 79557349
Bone marrow failure 37.44 11.18 189 145862 50918 79547419
Hepatic failure 37.15 11.18 215 145836 60997 79537340
Chronic obstructive pulmonary disease 37.09 11.18 62 145989 85357 79512980
Stomatitis 36.87 11.18 141 145910 146616 79451721
Endocarditis candida 36.62 11.18 12 146039 104 79598233
Dysgeusia 36.00 11.18 31 146020 57146 79541191
Cerebrovascular accident 36.00 11.18 154 145897 155138 79443199
Myoclonus 35.90 11.18 122 145929 27538 79570799
Suspected transmission of an infectious agent via product 35.83 11.18 24 146027 1162 79597175
Aspartate aminotransferase increased 35.77 11.18 400 145651 138241 79460096
Pulmonary interstitial emphysema syndrome 35.76 11.18 18 146033 505 79597832
Dysphonia 35.61 11.18 31 146020 56841 79541496
Vanishing bile duct syndrome 35.50 11.18 28 146023 1750 79596587
Pneumonia klebsiella 35.42 11.18 45 146006 5009 79593328
Infusion related reaction 35.08 11.18 262 145789 229975 79368362
Meningitis 35.08 11.18 63 145988 9519 79588818
Pulseless electrical activity 34.94 11.18 79 145972 14081 79584256
Sepsis syndrome 34.92 11.18 26 146025 1491 79596846
Palpitations 34.89 11.18 117 145934 126493 79471844
Urinary tract infection 34.78 11.18 328 145723 274184 79324153
Dehydration 34.76 11.18 289 145762 247898 79350439
Therapeutic product effect incomplete 34.37 11.18 138 145913 141507 79456830
Enterococcal sepsis 34.32 11.18 33 146018 2693 79595644
Lactobacillus infection 34.30 11.18 16 146035 378 79597959
Necrosis 34.22 11.18 62 145989 9431 79588906
Alveolar lung disease 34.09 11.18 18 146033 559 79597778
Hypersensitivity vasculitis 33.96 11.18 52 145999 6891 79591446
Rhinocerebral mucormycosis 33.39 11.18 22 146029 1036 79597301
Aplasia 33.33 11.18 55 145996 7765 79590572
Atelectasis 33.22 11.18 132 145919 32125 79566212
Influenza like illness 33.07 11.18 50 146001 71657 79526680
Foot deformity 33.03 11.18 3 146048 24071 79574266
Crystalluria 33.03 11.18 21 146030 930 79597407
Cytomegalovirus enterocolitis 32.91 11.18 26 146025 1629 79596708
Adverse event 32.89 11.18 37 146014 60177 79538160
Hepatitis 32.69 11.18 194 145857 55533 79542804
CNS ventriculitis 32.69 11.18 16 146035 422 79597915
Hospitalisation 32.67 11.18 78 145973 94158 79504179
Differentiation syndrome 32.62 11.18 31 146020 2493 79595844
Femur fracture 32.53 11.18 15 146036 38637 79559700
Injury 32.37 11.18 248 145803 77248 79521089
Mediastinitis 32.32 11.18 20 146031 844 79597493
Hyperammonaemia 32.09 11.18 66 145985 11027 79587310
Psychotic disorder 31.95 11.18 18 146033 41384 79556953
Infective aneurysm 31.91 11.18 21 146030 987 79597350
Overdose 31.83 11.18 202 145849 184004 79414333
Intentional self-injury 31.57 11.18 10 146041 32409 79565928
Anaphylactoid reaction 31.43 11.18 44 146007 5378 79592959
Febrile bone marrow aplasia 31.42 11.18 72 145979 12948 79585389
Activated partial thromboplastin time prolonged 31.42 11.18 76 145975 14152 79584185
Skin test positive 31.31 11.18 22 146029 1152 79597185
Thrombosis 31.28 11.18 67 145984 84033 79514304
Aminoaciduria 31.24 11.18 15 146036 379 79597958
Brain herniation 31.15 11.18 52 145999 7411 79590926
Cardiac disorder 31.15 11.18 45 146006 65712 79532625
Nightmare 31.13 11.18 5 146046 25856 79572481
Shock haemorrhagic 31.06 11.18 94 145957 19966 79578371
Streptococcal infection 30.98 11.18 57 145994 8773 79589564
Device issue 30.98 11.18 6 146045 27102 79571235
Pseudomonal bacteraemia 30.92 11.18 33 146018 3049 79595288
Candida sepsis 30.84 11.18 30 146021 2483 79595854
Sopor 30.72 11.18 11 146040 32999 79565338
Haemorrhagic pneumonia 30.68 11.18 11 146040 128 79598209
Gamma-glutamyltransferase increased 30.58 11.18 188 145863 54492 79543845
Meningitis bacterial 30.54 11.18 31 146020 2701 79595636
Liver abscess 30.54 11.18 46 146005 6008 79592329
Retinal vascular occlusion 30.48 11.18 17 146034 590 79597747
Pulse absent 30.28 11.18 61 145990 10042 79588295
Bacterial sepsis 30.14 11.18 54 145997 8144 79590193
Candida test positive 30.14 11.18 21 146030 1085 79597252
Cell death 30.07 11.18 40 146011 4659 79593678
Nocardiosis 29.87 11.18 44 146007 5635 79592702
Spinal stroke 29.82 11.18 8 146043 31 79598306
Exfoliative rash 29.68 11.18 36 146015 3823 79594514
Road traffic accident 29.59 11.18 22 146029 43642 79554695
Diabetes mellitus 29.53 11.18 62 145989 78328 79520009
Pulmonary trichosporonosis 29.52 11.18 9 146042 60 79598277
Torsade de pointes 29.44 11.18 90 145961 19222 79579115
Symmetrical drug-related intertriginous and flexural exanthema 29.37 11.18 19 146032 867 79597470
Intervertebral discitis 29.22 11.18 40 146011 4788 79593549
Hepatic enzyme increased 29.16 11.18 205 145846 182405 79415932
Orthostatic hypotension 29.08 11.18 36 146015 56128 79542209
Acne 29.07 11.18 7 146044 27183 79571154
Bacterial infection 29.05 11.18 124 145927 31156 79567181
Amnesia 29.05 11.18 44 146007 63013 79535324
Subperiosteal abscess 29.05 11.18 8 146043 35 79598302
Prescribed underdose 28.93 11.18 9 146042 29505 79568832
Extravasation 28.87 11.18 35 146016 3715 79594622
Lung infiltration 28.81 11.18 100 145951 22812 79575525
Heart rate decreased 28.75 11.18 53 145998 70263 79528074
Epidermolysis bullosa 28.72 11.18 12 146039 216 79598121
Abscess 28.71 11.18 100 145951 22851 79575486
Factor V inhibition 28.68 11.18 14 146037 367 79597970
Bone pain 28.58 11.18 36 146015 55706 79542631
Weissella infection 28.54 11.18 7 146044 17 79598320
Night sweats 28.47 11.18 32 146019 52063 79546274
Enterocolitis haemorrhagic 28.46 11.18 27 146024 2167 79596170
Diffuse alveolar damage 28.34 11.18 34 146017 3570 79594767
Empyema 28.29 11.18 37 146014 4239 79594098
Unresponsive to stimuli 28.23 11.18 187 145864 55601 79542736
Status epilepticus 27.85 11.18 105 145946 24936 79573401
Serum ferritin increased 27.79 11.18 58 145993 9789 79588548
Inflammatory marker increased 27.71 11.18 61 145990 10679 79587658
Underdose 27.69 11.18 13 146038 33138 79565199
Fungal endocarditis 27.61 11.18 16 146035 598 79597739
Respiratory gas exchange disorder 27.60 11.18 18 146033 833 79597504
Obesity 27.50 11.18 15 146036 35110 79563227
Pleocytosis 27.32 11.18 22 146029 1417 79596920
Breast cancer 27.07 11.18 14 146037 33767 79564570
Pregnancy 26.66 11.18 8 146043 26843 79571494
Diplopia 26.63 11.18 14 146037 33452 79564885
Meningitis candida 26.62 11.18 10 146041 134 79598203
Joint injury 26.62 11.18 12 146039 31323 79567014
Therapy non-responder 26.45 11.18 272 145779 92033 79506304
Injection site haemorrhage 26.43 11.18 9 146042 27861 79570476
Retinal ischaemia 26.37 11.18 17 146034 771 79597566
Hyperhidrosis 26.23 11.18 166 145885 151326 79447011
Visual impairment 26.17 11.18 84 145967 92047 79506290
COVID-19 26.17 11.18 175 145876 157499 79440838
Presyncope 26.16 11.18 22 146029 41032 79557305
Loss of consciousness 26.11 11.18 190 145861 167753 79430584
Aortoenteric fistula 26.03 11.18 10 146041 143 79598194
Angina pectoris 25.92 11.18 34 146017 51698 79546639
Aeromonas infection 25.88 11.18 13 146038 363 79597974
Dry eye 25.82 11.18 18 146033 36913 79561424
Hip fracture 25.79 11.18 12 146039 30749 79567588
Mucosal inflammation 25.75 11.18 231 145820 75349 79522988
Abdominal pain lower 25.73 11.18 13 146038 31769 79566568
Hypothyroidism 25.67 11.18 35 146016 52357 79545980
Herpes zoster 25.66 11.18 86 145965 92997 79505340
Abortion spontaneous 25.54 11.18 11 146040 29496 79568841
Abdominal pain 25.45 11.18 532 145519 389037 79209300
Full blood count abnormal 25.41 11.18 22 146029 40452 79557885
Bladder cancer 25.33 11.18 3 146048 19523 79578814
Diabetes insipidus 25.30 11.18 39 146012 5198 79593139
Sinus operation 25.27 11.18 27 146024 2498 79595839
Nonspecific reaction 25.21 11.18 27 146024 2505 79595832
Gastric disorder 25.19 11.18 19 146032 37414 79560923
Malignant neoplasm progression 25.12 11.18 146 145905 135844 79462493
Product prescribing error 25.07 11.18 27 146024 44786 79553551
Cystitis 25.07 11.18 36 146015 52696 79545641
Necrotising fasciitis 25.05 11.18 42 146009 6008 79592329
Pollakiuria 25.03 11.18 19 146032 37298 79561039
Dysuria 25.00 11.18 34 146017 50917 79547420
Oropharyngeal pain 25.00 11.18 109 145942 109244 79489093
Endocarditis staphylococcal 24.93 11.18 16 146035 720 79597617
Birdshot chorioretinopathy 24.87 11.18 8 146043 65 79598272
White blood cell count increased 24.86 11.18 227 145824 74406 79523931
Arthrofibrosis 24.78 11.18 9 146042 109 79598228
Cytomegalovirus infection 24.72 11.18 148 145903 42496 79555841
Joint stiffness 24.67 11.18 23 146028 40807 79557530
Strongyloidiasis 24.66 11.18 33 146018 3865 79594472
Lung neoplasm malignant 24.63 11.18 10 146041 27782 79570555
Continuous haemodiafiltration 24.62 11.18 24 146027 1992 79596345
Intraocular pressure increased 24.57 11.18 53 145998 9152 79589185
Bacterial pericarditis 24.45 11.18 8 146043 69 79598268
Nodule 24.43 11.18 6 146045 22988 79575349
Pseudomonas test positive 24.42 11.18 23 146028 1829 79596508
Ear pain 24.36 11.18 15 146036 32854 79565483
Clostridium colitis 24.34 11.18 28 146023 2811 79595526
Cryptococcosis 24.32 11.18 31 146020 3462 79594875
Hypoperfusion 24.28 11.18 27 146024 2612 79595725
Cerebral cyst 24.27 11.18 13 146038 416 79597921
Renal tubular injury 24.23 11.18 21 146030 1498 79596839
Pulmonary fibrosis 24.21 11.18 27 146024 44085 79554252
Toxic shock syndrome staphylococcal 24.18 11.18 5 146046 3 79598334
Neutropenic colitis 24.14 11.18 40 146011 5667 79592670
Toxic encephalopathy 24.08 11.18 60 145991 11380 79586957
Limb injury 24.02 11.18 12 146039 29516 79568821
Cryptococcal meningoencephalitis 24.02 11.18 11 146040 249 79598088
Vascular purpura 23.99 11.18 29 146022 3069 79595268
Tooth disorder 23.98 11.18 9 146042 26224 79572113
Head injury 23.84 11.18 20 146031 37349 79560988
Nephrolithiasis 23.77 11.18 38 146013 53253 79545084
Haemolysis 23.69 11.18 64 145987 12748 79585589
Throat irritation 23.66 11.18 24 146027 40922 79557415
Muscle abscess 23.61 11.18 18 146033 1070 79597267
Drug-induced liver injury 23.52 11.18 204 145847 65913 79532424
Immune reconstitution inflammatory syndrome 23.48 11.18 67 145984 13774 79584563
Gout 23.46 11.18 8 146043 24741 79573596
Leuconostoc infection 23.30 11.18 6 146045 19 79598318
Peritoneal effluent leukocyte count increased 23.30 11.18 6 146045 19 79598318
Impaired work ability 23.26 11.18 4 146047 19677 79578660
Citrobacter infection 23.17 11.18 17 146034 953 79597384
Abdominal distension 22.89 11.18 127 145924 119523 79478814
Avian influenza 22.80 11.18 8 146043 87 79598250
Skin necrosis 22.79 11.18 79 145972 18008 79580329
Productive cough 22.74 11.18 84 145967 88247 79510090
Injection site rash 22.70 11.18 3 146048 17951 79580386
Osteomyelitis fungal 22.58 11.18 11 146040 287 79598050
Escherichia bacteraemia 22.57 11.18 42 146009 6520 79591817
Procalcitonin abnormal 22.57 11.18 12 146039 378 79597959
Hepatomegaly 22.55 11.18 81 145970 18793 79579544
Botulism 22.54 11.18 12 146039 379 79597958
Rash pruritic 22.42 11.18 215 145836 71414 79526923
Clostridium bacteraemia 22.34 11.18 12 146039 386 79597951
Disseminated mucormycosis 22.27 11.18 15 146036 733 79597604
Overgrowth fungal 22.24 11.18 8 146043 94 79598243
Blood lactate dehydrogenase increased 22.11 11.18 135 145916 39035 79559302
Abscess neck 22.09 11.18 18 146033 1179 79597158
Central nervous system injury 21.95 11.18 9 146042 154 79598183
Fungal infection 21.76 11.18 141 145910 41607 79556730
Pyelonephritis fungal 21.73 11.18 10 146041 229 79598108
Hypogonadism 21.58 11.18 21 146030 1739 79596598
Hypervolaemia 21.54 11.18 143 145908 42547 79555790
Encephalomalacia 21.52 11.18 18 146033 1223 79597114
Acute graft versus host disease in skin 21.49 11.18 45 146006 7613 79590724
Mood swings 21.49 11.18 5 146046 19875 79578462
Musculoskeletal discomfort 21.42 11.18 5 146046 19830 79578507
Arthritis bacterial 21.36 11.18 50 146001 9116 79589221
Drug interaction 21.34 11.18 947 145104 414236 79184101
Fungal test positive 21.33 11.18 17 146034 1079 79597258
Candida endophthalmitis 21.29 11.18 9 146042 167 79598170
Hypersensitivity 21.21 11.18 345 145706 261894 79336443
Scoliosis 21.11 11.18 44 146007 7420 79590917
Glomerular filtration rate decreased 21.09 11.18 90 145961 22612 79575725
Ankle fracture 21.07 11.18 3 146048 16966 79581371
Uterine fistula 21.05 11.18 5 146046 10 79598327
Joint range of motion decreased 21.01 11.18 18 146033 33264 79565073
Carpal tunnel syndrome 20.93 11.18 5 146046 19523 79578814
Pruritus 20.91 11.18 903 145148 393745 79204592
Grip strength decreased 20.85 11.18 7 146044 21862 79576475
Movement disorder 20.82 11.18 12 146039 27247 79571090
Acinetobacter test positive 20.81 11.18 10 146041 253 79598084
Uveitis 20.77 11.18 73 145978 16757 79581580
Wrong rate 20.75 11.18 7 146044 67 79598270
Infusion site necrosis 20.75 11.18 7 146044 67 79598270
Electrocardiogram QT prolonged 20.74 11.18 255 145796 90131 79508206
Leukaemoid reaction 20.73 11.18 11 146040 345 79597992
Hyperlipidaemia 20.64 11.18 11 146040 26082 79572255
Streptococcal bacteraemia 20.51 11.18 29 146022 3577 79594760
Maternal exposure during pregnancy 20.49 11.18 156 145895 136382 79461955
Parkinsonism 20.43 11.18 3 146048 16581 79581756
Rash pustular 20.41 11.18 56 145995 11255 79587082
Lymphadenopathy 20.37 11.18 167 145884 53080 79545257
Corynebacterium infection 20.35 11.18 18 146033 1320 79597017
Allergy test positive 20.25 11.18 14 146037 714 79597623
Pneumothorax 20.22 11.18 104 145947 28219 79570118
Cardiovascular somatic symptom disorder 20.22 11.18 6 146045 36 79598301
Neoplasm progression 20.21 11.18 40 146011 51642 79546695
Blood test abnormal 20.07 11.18 4 146047 17706 79580631
Nervousness 19.98 11.18 19 146032 33396 79564941
Restless legs syndrome 19.92 11.18 6 146045 20086 79578251
Prescribed overdose 19.91 11.18 24 146027 37859 79560478
Toothache 19.73 11.18 6 146045 19964 79578373
Osteomyelitis 19.65 11.18 115 145936 32750 79565587
Meningitis eosinophilic 19.62 11.18 5 146046 15 79598322
Serum sickness-like reaction 19.55 11.18 13 146038 622 79597715
Deafness bilateral 19.50 11.18 22 146029 2163 79596174
Poisoning 19.48 11.18 11 146040 25261 79573076
Panic attack 19.46 11.18 10 146041 24206 79574131
Janeway lesion 19.38 11.18 5 146046 16 79598321
Peripheral venous disease 19.32 11.18 3 146048 15906 79582431
Renal abscess 19.26 11.18 16 146035 1077 79597260
Palpable purpura 19.22 11.18 10 146041 301 79598036
Toxicity to various agents 19.15 11.18 607 145444 420933 79177404
Fusarium infection 19.06 11.18 20 146031 1812 79596525
Pneumonia bacterial 19.02 11.18 78 145973 19253 79579084
Vessel puncture site inflammation 18.99 11.18 4 146047 3 79598334
Jarisch-Herxheimer reaction 18.96 11.18 15 146036 942 79597395
Wound dehiscence 18.79 11.18 39 146012 6556 79591781
Intra-abdominal fluid collection 18.78 11.18 26 146025 3146 79595191
Urinary retention 18.75 11.18 48 146003 56582 79541755
Metastases to bone marrow 18.73 11.18 14 146037 808 79597529
Glycosylated haemoglobin increased 18.65 11.18 6 146045 19254 79579083
Disseminated sporotrichosis 18.62 11.18 6 146045 49 79598288
Graft versus host disease in gastrointestinal tract 18.60 11.18 38 146013 6318 79592019
Antinuclear antibody negative 18.51 11.18 5 146046 20 79598317
Platelet dysfunction 18.51 11.18 11 146040 431 79597906
Pulmonary mucormycosis 18.37 11.18 16 146035 1149 79597188
Injection site mass 18.32 11.18 7 146044 20177 79578160
Autoimmune disorder 18.31 11.18 4 146047 16608 79581729
Bone erosion 18.30 11.18 5 146046 17842 79580495
Endocarditis bacterial 18.29 11.18 18 146033 1511 79596826
Interleukin-2 receptor increased 18.26 11.18 9 146042 241 79598096
Abnormal behaviour 18.18 11.18 24 146027 36397 79561940
Acute coronary syndrome 18.10 11.18 8 146043 21125 79577212
Pulmonary alveolar haemorrhage 18.03 11.18 54 145997 11403 79586934
Seasonal allergy 17.98 11.18 4 146047 16402 79581935
Vitamin K deficiency 17.94 11.18 13 146038 715 79597622
Metastases to muscle 17.85 11.18 10 146041 350 79597987
Bacterial endophthalmitis 17.84 11.18 8 146043 172 79598165
Foot fracture 17.78 11.18 9 146042 21972 79576365
Colitis 17.77 11.18 209 145842 73098 79525239
Wrong patient received product 17.73 11.18 31 146020 4587 79593750
Pneumonia necrotising 17.65 11.18 16 146035 1211 79597126
Lung abscess 17.63 11.18 29 146022 4083 79594254
Urinary tract infection pseudomonal 17.59 11.18 19 146032 1779 79596558
Lip oedema 17.59 11.18 37 146014 6279 79592058
Red blood cell sedimentation rate increased 17.59 11.18 36 146015 45906 79552431
Splenic injury 17.55 11.18 9 146042 263 79598074
Dysstasia 17.52 11.18 15 146036 27731 79570606
Gastroenteritis viral 17.49 11.18 12 146039 24819 79573518
Eating disorder 17.46 11.18 8 146043 20689 79577648
Middle insomnia 17.45 11.18 4 146047 16065 79582272
Malignant melanoma 17.41 11.18 3 146048 14738 79583599
Peritonitis 17.35 11.18 99 145952 27937 79570400
Encephalitis 17.34 11.18 63 145988 14697 79583640
Progressive multifocal leukoencephalopathy 17.32 11.18 8 146043 20592 79577745
Erectile dysfunction 17.28 11.18 3 146048 14661 79583676
Laryngeal stenosis 17.27 11.18 15 146036 1073 79597264
Capillary leak syndrome 17.26 11.18 28 146023 3897 79594440
Metabolic encephalopathy 17.22 11.18 46 146005 9101 79589236
Delusion 17.07 11.18 8 146043 20415 79577922
Liver transplant failure 17.06 11.18 7 146044 120 79598217
Taste disorder 17.06 11.18 4 146047 15819 79582518
Malnutrition 17.03 11.18 84 145967 22418 79575919
Head discomfort 17.02 11.18 3 146048 14499 79583838
Cavernous sinus thrombosis 16.92 11.18 10 146041 388 79597949
Bronchiectasis 16.89 11.18 10 146041 22376 79575961
Neoplasm malignant 16.88 11.18 20 146031 31790 79566547
Tremor 16.82 11.18 215 145836 169868 79428469
Metastases to retroperitoneum 16.78 11.18 10 146041 394 79597943
Exostosis 16.78 11.18 5 146046 16853 79581484
Abdominal abscess 16.74 11.18 39 146012 7088 79591249
Interstitial lung disease 16.73 11.18 129 145922 112471 79485866
Chemical peritonitis 16.69 11.18 9 146042 292 79598045
Eosinophils urine present 16.65 11.18 6 146045 71 79598266
Oedema peripheral 16.61 11.18 344 145707 251944 79346393
Mood altered 16.52 11.18 6 146045 17841 79580496
Hypercholesterolaemia 16.49 11.18 11 146040 23084 79575253
Hypersomnia 16.47 11.18 11 146040 23075 79575262
Intensive care unit acquired weakness 16.47 11.18 19 146032 1914 79596423
Blood iron decreased 16.45 11.18 4 146047 15430 79582907
Adenovirus infection 16.43 11.18 43 146008 8404 79589933
Feeling cold 16.41 11.18 17 146034 28712 79569625
Thyroid disorder 16.33 11.18 3 146048 14076 79584261
Puerperal pyrexia 16.31 11.18 5 146046 34 79598303
Angina unstable 16.27 11.18 5 146046 16522 79581815
Hypoglycaemia 16.24 11.18 114 145937 101480 79496857
Body temperature decreased 16.23 11.18 21 146030 32124 79566213
Hyperaemia 16.22 11.18 24 146027 3086 79595251
Cardiac valve abscess 16.19 11.18 5 146046 35 79598302
Manipulation 16.14 11.18 6 146045 78 79598259
Fracture 16.09 11.18 10 146041 21791 79576546
Splenomegaly 16.09 11.18 78 145973 20676 79577661
Product use in unapproved indication 16.08 11.18 585 145466 249774 79348563
Drug trough level 16.07 11.18 5 146046 36 79598301
Corneal opacity 16.07 11.18 14 146037 1006 79597331
Systemic mycosis 16.00 11.18 22 146029 2644 79595693
Poor quality sleep 15.98 11.18 11 146040 22711 79575626
Circulatory collapse 15.98 11.18 121 145930 37547 79560790
Haemangioma congenital 15.91 11.18 3 146048 0 79598337
Ear infection 15.88 11.18 24 146027 34408 79563929
Respiratory tract infection fungal 15.87 11.18 15 146036 1198 79597139
Distributive shock 15.87 11.18 22 146029 2665 79595672
Wheezing 15.80 11.18 137 145914 116527 79481810
Fixed eruption 15.70 11.18 23 146028 2931 79595406
Nocturia 15.69 11.18 3 146048 13678 79584659
Urinary tract infection fungal 15.68 11.18 14 146037 1039 79597298
Retinal exudates 15.64 11.18 15 146036 1220 79597117
Muscle spasticity 15.64 11.18 10 146041 21465 79576872
Red blood cell schistocytes present 15.62 11.18 11 146040 578 79597759
Musculoskeletal disorder 15.60 11.18 10 146041 21438 79576899
Endocarditis enterococcal 15.59 11.18 7 146044 151 79598186
Chills 15.57 11.18 394 145657 159840 79438497
Laryngitis 15.52 11.18 5 146046 16034 79582303
Obstructive airways disorder 15.43 11.18 21 146030 31438 79566899
Bacterial toxaemia 15.38 11.18 7 146044 156 79598181
Peripheral sensorimotor neuropathy 15.37 11.18 23 146028 2987 79595350
Hernia 15.35 11.18 6 146045 17053 79581284
Respiratory alkalosis 15.34 11.18 28 146023 4283 79594054
Abscess fungal 15.18 11.18 9 146042 351 79597986
Endometrial disorder 15.16 11.18 11 146040 606 79597731
Lung disorder 15.13 11.18 86 145965 80471 79517866
Hepatosplenomegaly 15.13 11.18 34 146017 6035 79592302
Infective thrombosis 15.12 11.18 6 146045 94 79598243
Respiratory acidosis 15.07 11.18 50 146001 11150 79587187
Periostosis 15.01 11.18 4 146047 15 79598322
Aortic pseudoaneurysm 15.00 11.18 5 146046 46 79598291
Surgery 14.96 11.18 23 146028 32743 79565594
HIV viraemia 14.95 11.18 6 146045 97 79598240
Flavobacterium infection 14.95 11.18 6 146045 97 79598240
Therapeutic response unexpected 14.93 11.18 9 146042 19937 79578400
Drug level decreased 14.88 11.18 59 145992 14343 79583994
Sinus congestion 14.86 11.18 9 146042 19887 79578450
Extradural abscess 14.83 11.18 16 146035 1496 79596841
Osmotic demyelination syndrome 14.83 11.18 16 146035 1497 79596840
Pulmonary embolism 14.82 11.18 223 145828 171431 79426906
Liver disorder 14.80 11.18 200 145851 72217 79526120
Sinus tachycardia 14.79 11.18 117 145934 36791 79561546
Epidermal necrosis 14.79 11.18 16 146035 1501 79596836
Pneumococcal infection 14.79 11.18 13 146038 945 79597392
Lymphocyte morphology abnormal 14.79 11.18 13 146038 945 79597392
Stenotrophomonas test positive 14.71 11.18 9 146042 372 79597965
Hypopyon 14.71 11.18 14 146037 1128 79597209
Neuralgia 14.70 11.18 24 146027 33360 79564977
Wrong product administered 14.68 11.18 43 146008 8969 79589368
Acute hepatic failure 14.67 11.18 100 145951 30013 79568324
Chronic sinusitis 14.64 11.18 3 146048 13023 79585314
Immunosuppressant drug level increased 14.64 11.18 43 146008 8984 79589353
Anti factor Xa activity decreased 14.62 11.18 4 146047 17 79598320
Sneezing 14.56 11.18 9 146042 19674 79578663
Spinal pain 14.54 11.18 5 146046 15387 79582950
Gas gangrene 14.52 11.18 8 146043 271 79598066
Thirst 14.50 11.18 8 146043 18611 79579726
Visual acuity reduced 14.44 11.18 98 145953 29371 79568966
Pericarditis fungal 14.43 11.18 7 146044 181 79598156
Coronary artery occlusion 14.43 11.18 5 146046 15310 79583027
Eye pruritus 14.41 11.18 10 146041 20560 79577777
Rotator cuff syndrome 14.36 11.18 4 146047 14091 79584246
Vestibular disorder 14.35 11.18 20 146031 2435 79595902
Metastases to central nervous system 14.34 11.18 6 146045 16369 79581968
Infusion site streaking 14.33 11.18 10 146041 518 79597819
Pancreatitis haemorrhagic 14.31 11.18 12 146039 818 79597519
Flatulence 14.31 11.18 36 146015 42688 79555649
ADAMTS13 activity decreased 14.29 11.18 7 146044 185 79598152
Haemostasis 14.27 11.18 9 146042 393 79597944
Sedation 14.26 11.18 48 146003 51847 79546490
Cerebral aspergillosis 14.21 11.18 17 146034 1779 79596558
Limbal swelling 14.09 11.18 4 146047 20 79598317
Meningitis fungal 14.09 11.18 7 146044 191 79598146
Gastritis fungal 14.09 11.18 7 146044 191 79598146
Post procedural complication 14.00 11.18 83 145968 23746 79574591
Product substitution issue 13.99 11.18 10 146041 20246 79578091
Pharyngeal inflammation 13.98 11.18 13 146038 1017 79597320
Azotaemia 13.98 11.18 40 146011 8236 79590101
Drug chemical incompatibility 13.97 11.18 6 146045 116 79598221
Klebsiella bacteraemia 13.96 11.18 22 146029 2988 79595349
Hyperpyrexia 13.94 11.18 33 146018 6059 79592278
Pneumatosis intestinalis 13.94 11.18 34 146017 6363 79591974
Hypokalaemia 13.94 11.18 354 145697 143686 79454651
Uterine necrosis 13.84 11.18 3 146048 3 79598334
Tumour lysis syndrome 13.82 11.18 83 145968 23856 79574481
Bone disorder 13.78 11.18 9 146042 19104 79579233
Ureaplasma infection 13.77 11.18 13 146038 1037 79597300
Spinal fracture 13.72 11.18 8 146043 18046 79580291
Blood creatine phosphokinase increased 13.70 11.18 183 145868 65907 79532430
Blastomycosis 13.67 11.18 11 146040 708 79597629
Tetanus 13.66 11.18 5 146046 62 79598275
Toxic shock syndrome streptococcal 13.64 11.18 6 146045 123 79598214
Dementia 13.63 11.18 15 146036 24644 79573693
Periphlebitis 13.62 11.18 4 146047 23 79598314
Joint dislocation 13.60 11.18 7 146044 16932 79581405
Periorbital oedema 13.60 11.18 40 146011 8362 79589975
Platelet transfusion 13.57 11.18 19 146032 2323 79596014
Cystic fibrosis 13.56 11.18 25 146026 3855 79594482
Acute myeloid leukaemia 13.55 11.18 100 145951 30785 79567552
Skin laceration 13.54 11.18 20 146031 28942 79569395
Nephritis allergic 13.52 11.18 11 146040 719 79597618
Irritability 13.52 11.18 35 146016 41109 79557228
Ischaemic stroke 13.52 11.18 25 146026 33106 79565231
Peripheral ischaemia 13.42 11.18 43 146008 9414 79588923
Rectal perforation 13.41 11.18 12 146039 893 79597444
Wound infection bacterial 13.41 11.18 12 146039 893 79597444
Respiratory tract infection 13.40 11.18 45 146006 48644 79549693
Poor quality product administered 13.39 11.18 24 146027 3621 79594716
Metastases to bone 13.35 11.18 15 146036 24412 79573925
Ileus 13.34 11.18 88 145963 26123 79572214
Splenic infarction 13.30 11.18 24 146027 3640 79594697
Excessive eye blinking 13.30 11.18 16 146035 1685 79596652
Urinary incontinence 13.29 11.18 35 146016 40874 79557463
Brain death 13.26 11.18 31 146020 5646 79592691
Mycobacterial peritonitis 13.24 11.18 5 146046 68 79598269
Mast cell degranulation present 13.24 11.18 5 146046 68 79598269
Therapy naive 13.24 11.18 5 146046 68 79598269
Bone density decreased 13.21 11.18 4 146047 13343 79584994
Acantholysis 13.21 11.18 4 146047 26 79598311
Bacteroides test positive 13.21 11.18 4 146047 26 79598311
Lacrimation increased 13.18 11.18 13 146038 22464 79575873
Large intestinal ulcer haemorrhage 13.18 11.18 8 146043 326 79598011
Encephalitis Japanese B 13.18 11.18 5 146046 69 79598268
Postoperative renal failure 13.13 11.18 6 146045 135 79598202
Hydrocephalus 13.12 11.18 41 146010 8859 79589478
Escherichia test positive 13.09 11.18 22 146029 3153 79595184
Holmes-Adie pupil 13.08 11.18 4 146047 27 79598310
Device dislocation 13.08 11.18 17 146034 25953 79572384
Full blood count decreased 13.05 11.18 18 146033 26801 79571536
Red cell distribution width abnormal 13.01 11.18 7 146044 226 79598111
Complications of transplanted kidney 12.99 11.18 33 146018 6333 79592004
Dystonia 12.99 11.18 12 146039 21387 79576950
Morganella infection 12.99 11.18 13 146038 1114 79597223
Wernicke's encephalopathy 12.95 11.18 4 146047 28 79598309
Ischaemic enteritis 12.93 11.18 6 146045 140 79598197
Hepatitis cholestatic 12.93 11.18 55 145996 13797 79584540
Clostridial sepsis 12.91 11.18 12 146039 938 79597399
Macule 12.88 11.18 21 146030 2936 79595401
Anal skin tags 12.87 11.18 9 146042 468 79597869
Implant site hypersensitivity 12.83 11.18 4 146047 29 79598308
Thrombophlebitis septic 12.79 11.18 8 146043 344 79597993
Needle issue 12.78 11.18 4 146047 13064 79585273
Urine output decreased 12.74 11.18 66 145985 17956 79580381
Ventricular tachycardia 12.69 11.18 125 145926 41810 79556527
Generalised onset non-motor seizure 12.68 11.18 5 146046 77 79598260
Apathy 12.64 11.18 4 146047 12973 79585364
Mania 12.63 11.18 9 146042 18251 79580086
Allergic eosinophilia 12.63 11.18 3 146048 6 79598331
Gastric ulcer 12.61 11.18 27 146024 33878 79564459
Protein C decreased 12.56 11.18 5 146046 79 79598258
Metastases to spleen 12.56 11.18 10 146041 634 79597703
Renal disorder 12.50 11.18 125 145926 41980 79556357
Disseminated trichosporonosis 12.48 11.18 6 146045 152 79598185
Pneumonia pseudomonal 12.44 11.18 31 146020 5880 79592457
Unmasking of previously unidentified disease 12.38 11.18 17 146034 2040 79596297
Intestinal obstruction 12.37 11.18 39 146012 42981 79555356
Pancreatic pseudocyst 12.35 11.18 14 146037 1383 79596954
Lemierre syndrome 12.34 11.18 6 146045 156 79598181
Rash vesicular 12.33 11.18 31 146020 5914 79592423
Psychological trauma 12.28 11.18 14 146037 1392 79596945
Organising pneumonia 12.27 11.18 46 146005 10893 79587444
Epistaxis 12.15 11.18 138 145913 111377 79486960
Ovarian cyst 12.15 11.18 4 146047 12651 79585686
Product use issue 12.12 11.18 292 145759 209530 79388807
Eye excision 12.07 11.18 5 146046 88 79598249
Diabetic ketoacidosis 12.02 11.18 28 146023 34094 79564243
Hiatus hernia 12.01 11.18 15 146036 23297 79575040
Alpha haemolytic streptococcal infection 12.00 11.18 18 146033 2342 79595995
Speech disorder 12.00 11.18 55 145996 54390 79543947
Spinal stenosis 11.99 11.18 7 146044 15784 79582553
Coeliac disease 11.98 11.18 3 146048 11348 79586989
Cytokine storm 11.93 11.18 12 146039 1034 79597303
Wound infection staphylococcal 11.93 11.18 21 146030 3123 79595214
Abscess limb 11.90 11.18 34 146017 6993 79591344
Macular degeneration 11.90 11.18 3 146048 11293 79587044
Multiple sclerosis 11.83 11.18 14 146037 22268 79576069
Palmar-plantar erythrodysaesthesia syndrome 11.82 11.18 27 146024 33107 79565230
Skin irritation 11.81 11.18 3 146048 11237 79587100
Ageusia 11.77 11.18 8 146043 16624 79581713
Hepatic steatosis 11.73 11.18 33 146018 37705 79560632
Renal graft infection 11.72 11.18 9 146042 541 79597796
Crying 11.69 11.18 15 146036 23028 79575309
Viral infection 11.68 11.18 40 146011 42976 79555361
Respiratory moniliasis 11.65 11.18 7 146044 280 79598057
Vaginal abscess 11.64 11.18 8 146043 404 79597933
Therapy interrupted 11.63 11.18 25 146026 31316 79567021
Diverticulitis 11.62 11.18 44 146007 45892 79552445
Acute graft versus host disease 11.61 11.18 43 146008 10124 79588213
Bandaemia 11.56 11.18 8 146043 409 79597928
Limb discomfort 11.54 11.18 27 146024 32823 79565514
Sputum culture positive 11.53 11.18 23 146028 3758 79594579
Potentiating drug interaction 11.53 11.18 39 146012 8780 79589557
Deafness permanent 11.53 11.18 3 146048 10 79598327
Ependymitis 11.53 11.18 3 146048 10 79598327
Photosensitivity reaction 11.52 11.18 13 146038 21114 79577223
Gastritis 11.48 11.18 47 146004 47946 79550391
Pelvic fracture 11.47 11.18 4 146047 12200 79586137
Polyarthritis 11.47 11.18 4 146047 12198 79586139
Product compounding quality issue 11.44 11.18 4 146047 43 79598294
Cardiovascular insufficiency 11.43 11.18 20 146031 2961 79595376
Akathisia 11.38 11.18 5 146046 13254 79585083
Coordination abnormal 11.38 11.18 9 146042 17303 79581034
Type I hypersensitivity 11.37 11.18 25 146026 4373 79593964
Adverse drug reaction 11.36 11.18 73 145978 66319 79532018
Choking 11.32 11.18 4 146047 12097 79586240
Blast cell proliferation 11.31 11.18 3 146048 11 79598326
Blood pressure diastolic decreased 11.29 11.18 24 146027 30192 79568145
Vaginal haemorrhage 11.28 11.18 14 146037 21803 79576534
Nutritional condition abnormal 11.28 11.18 12 146039 1105 79597232
Oral pain 11.27 11.18 26 146025 31772 79566565
Hyponatraemia 11.26 11.18 244 145807 177604 79420733
Vulvovaginitis 11.26 11.18 7 146044 298 79598039
Meningitis aseptic 11.23 11.18 33 146018 6895 79591442
Culture urine positive 11.23 11.18 25 146026 4410 79593927
Burkholderia test positive 11.23 11.18 9 146042 576 79597761
Hepatitis fulminant 11.21 11.18 34 146017 7228 79591109
Tooth abscess 11.20 11.18 8 146043 16202 79582135
Pulmonary valve disease 11.19 11.18 7 146044 301 79598036
Gastroenteritis staphylococcal 11.19 11.18 7 146044 301 79598036

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 50.52 26.56 41 401 1011 88339
Foetal exposure during pregnancy 49.78 26.56 5 437 12836 76514
Systemic candida 32.55 26.56 11 431 33 89317

Pharmacologic Action:

SourceCodeDescription
ATC A07AA09 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC J01XA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Glycopeptide antibacterials
ATC S01AA28 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antibiotics
FDA CS M0009481 Glycopeptides
FDA EPC N0000175491 Glycopeptide Antibacterial
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bacterial septicemia indication 10001005 DOID:0040085
Staphylococcal pneumonia indication 22754005
Staphylococcal enterocolitis indication 32527003
Lower respiratory tract infection indication 50417007
Staphylococcal infectious disease indication 56038003
Staphylococcal endocarditis indication 73028002
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Sepsis of the newborn indication 206376005
Neonatal pneumonia indication 233619008
Infective endocarditis indication 233850007
Bacterial endocarditis indication 301183007
Infectious disorder of joint indication 363162000
Pseudomembranous enterocolitis indication 397683000
Infection due to Staphylococcus aureus indication 406602003
Osteomyelitis due to Staphylococcus aureus indication 428783003
Streptococcal Endocarditis indication
Prosthetic Heart Valve Endocarditis indication
Staphylococcus Epidermidis Skin and Skin Structure Infection indication
Neonatal Group B Streptococcal Septicemia indication
Staphylococcal Prosthetic Heart Valve Endocarditis indication
Diphtheroid Prosthetic Heart Valve Endocarditis indication
Clostridium difficile diarrhea indication
Streptococcal meningitis off-label use 4510004 DOID:11574
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Staphylococcal meningitis off-label use 12166008
Diphtheritic myocarditis off-label use 26117009
Erysipelas off-label use 44653001 DOID:11330
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Neonatal meningitis off-label use 276674008
Anthrax off-label use 409498004 DOID:7427
Abscess of brain off-label use 441806004
Perioperative Infection off-label use
Listeria Monocytogenes Septicemia off-label use
Prevention of Perioperative Infection off-label use
Diabetic Foot Infection Due to Gram-Positive Bacteria off-label use
Acute nephropathy contraindication 58574008
Kidney disease contraindication 90708001 DOID:557
Hearing disorder contraindication 128540005
Vancomycin poisoning contraindication 291518001
Neutropenic disorder contraindication 303011007 DOID:1227




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.55 acidic
pKa2 7.69 acidic
pKa3 10.72 acidic
pKa4 11.48 acidic
pKa5 11.49 acidic
pKa6 12.17 acidic
pKa7 12.41 acidic
pKa8 12.78 acidic
pKa9 13.04 acidic
pKa10 13.2 acidic
pKa11 13.59 acidic
pKa12 8.96 Basic
pKa13 8.3 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 25MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959947 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959948 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF C. DIFFICILE-ASSOCIATED DIARRHEA
EQ 50MG BASE/ML FIRVANQ KIT AZURITY N208910 Jan. 26, 2018 RX FOR SOLUTION ORAL 10959949 March 13, 2035 TREATMENT OF STAPHYLOCOCCAL ENTEROCOLITIS
EQ 1.25GM BASE/250ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.25GM BASE/250ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.25GM BASE/250ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.5GM BASE/300ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.75GM BASE/350ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.75GM BASE/350ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1.75GM BASE/350ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 1GM BASE/200ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 2GM BASE/400ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 500MG BASE/100ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 Feb. 15, 2019 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 750MG BASE/150ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 750MG BASE/150ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
EQ 750MG BASE/150ML (EQ 5MG BASE/ML) VANCOMYCIN HYDROCHLORIDE XELLIA PHARMS APS N211962 May 13, 2020 RX SOLUTION INTRAVENOUS 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
5GM/100ML (50MG/ML) VANCOMYCIN XELLIA PHARMS APS N213895 Aug. 26, 2021 RX SOLUTION INTRAVENOUS, ORAL 10039804 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
5GM/100ML (50MG/ML) VANCOMYCIN XELLIA PHARMS APS N213895 Aug. 26, 2021 RX SOLUTION INTRAVENOUS, ORAL 10188697 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS
5GM/100ML (50MG/ML) VANCOMYCIN XELLIA PHARMS APS N213895 Aug. 26, 2021 RX SOLUTION INTRAVENOUS, ORAL 11517609 Nov. 6, 2035 METHOD OF TREATING BACTERIAL INFECTIONS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 250MG BASE/5ML VANCOMYCIN HYDROCHLORIDE AMNEAL A215338 June 23, 2023 RX FOR SOLUTION ORAL Dec. 20, 2023 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 7.30 CHEMBL
D-alanyl-D-alanine dipeptidase Enzyme Ki 4.21 CHEMBL
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Enzyme IC50 5 CHEMBL

External reference:

IDSource
4019967 VUID
N0000148052 NUI
D00212 KEGG_DRUG
1404-93-9 SECONDARY_CAS_RN
4017454 VANDF
4019967 VANDF
C0042313 UMLSCUI
CHEBI:28001 CHEBI
CHEMBL262777 ChEMBL_ID
CHEMBL1200628 ChEMBL_ID
D014640 MESH_DESCRIPTOR_UI
DB00512 DRUGBANK_ID
10932 IUPHAR_LIGAND_ID
680 INN_ID
6Q205EH1VU UNII
14969 PUBCHEM_CID
11124 RXNORM
253520 MMSL
30222 MMSL
3125 MMSL
38014 MMSL
41853 MMSL
4652 MMSL
5664 MMSL
7306 MMSL
d00125 MMSL
002791 NDDF
004866 NDDF
372735009 SNOMEDCT_US
42082003 SNOMEDCT_US
66509009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0867 CAPSULE 125 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0867 CAPSULE 125 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0867 CAPSULE 125 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0867 CAPSULE 125 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0890 CAPSULE 250 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0890 CAPSULE 250 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0890 CAPSULE 250 mg ORAL ANDA 26 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0121-0890 CAPSULE 250 mg ORAL ANDA 26 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9152 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.25 g INTRAVENOUS ANDA 29 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9153 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1.50 g INTRAVENOUS ANDA 29 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9161 INJECTION, POWDER, FOR SOLUTION 513 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9162 INJECTION, POWDER, FOR SOLUTION 1025 mg INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9163 INJECTION, POWDER, FOR SOLUTION 5.13 g INTRAVENOUS NDA 30 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0143-9164 INJECTION, POWDER, FOR SOLUTION 10.25 g INTRAVENOUS NDA 30 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9355 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 750 mg INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9355 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 750 mg INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9356 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9357 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9358 INJECTION, POWDER, FOR SOLUTION 5 g INTRAVENOUS ANDA 22 sections
Vancomycin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9359 INJECTION, POWDER, FOR SOLUTION 10 g INTRAVENOUS ANDA 22 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3551 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3551 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3552 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3552 INJECTION, SOLUTION 1 g INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3580 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3580 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3581 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3581 INJECTION, SOLUTION 500 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3582 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 23 sections
VANCOMYCIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0338-3582 INJECTION, SOLUTION 750 mg INTRAVENOUS NDA 23 sections