teicoplanin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
glycopeptide antibacterials (Actinoplanes strains)	2998	61036-62-2

Description:

Molecule	Description
Synonyms: teicoplanin Antibiotic 8327A Antibiotic MDL 507 targocid targosid teichomycin	Lipoglycopeptide antibiotic from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety. Molecular weight: Formula: None CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

teicoplanin
Antibiotic 8327A
Antibiotic MDL 507
targocid
targosid
teichomycin

Lipoglycopeptide antibiotic from Actinoplanes teichomyceticus active against gram-positive bacteria. It consists of five major components each with a different fatty acid moiety.

Molecular weight:
Formula: None
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.40	g	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms	221.99	32.99	84	4196	33752	63450990
Thrombocytopenia	87.41	32.99	76	4204	151081	63333661
Acinetobacter infection	84.82	32.99	20	4260	1563	63483179
Stenotrophomonas infection	74.94	32.99	19	4261	2008	63482734
Pyrexia	72.32	32.99	120	4160	470358	63014384
Septic shock	65.71	32.99	46	4234	66583	63418159
Multiple organ dysfunction syndrome	62.62	32.99	42	4238	56710	63428032
Anaphylactic reaction	61.40	32.99	44	4236	66056	63418686
Drug resistance	54.73	32.99	28	4252	22905	63461837
Enterococcal infection	53.22	32.99	20	4260	7828	63476914
Neutropenia	52.97	32.99	62	4218	174943	63309799
Rash maculo-papular	51.31	32.99	30	4250	31866	63452876
Mental status changes postoperative	49.56	32.99	9	4271	191	63484551
Confusion postoperative	47.70	32.99	9	4271	237	63484505
Haemodynamic instability	46.70	32.99	19	4261	9171	63475571
Acute generalised exanthematous pustulosis	46.51	32.99	20	4260	11079	63473663
Cross sensitivity reaction	45.55	32.99	13	4267	2149	63482593
Morganella infection	44.04	32.99	10	4270	661	63484081
Eosinophilia	43.60	32.99	24	4256	22732	63462010
Pathogen resistance	42.28	32.99	16	4264	6382	63478360
Haemostasis	41.33	32.99	8	4272	242	63484500
Klebsiella infection	41.11	32.99	17	4263	8549	63476193
Bronchopulmonary aspergillosis	40.98	32.99	17	4263	8618	63476124
Pancytopenia	40.97	32.99	41	4239	96892	63387850
Febrile neutropenia	40.96	32.99	45	4235	118404	63366338
Renal impairment	38.50	32.99	38	4242	88317	63396425
Sepsis	36.26	32.99	48	4232	153075	63331667

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms	147.17	24.23	82	5622	32930	34918297
Pyrexia	116.85	24.23	200	5504	332813	34618414
Cross sensitivity reaction	88.04	24.23	24	5680	1373	34949854
Multiple organ dysfunction syndrome	79.58	24.23	79	5625	76487	34874740
Venoocclusive disease	71.02	24.23	24	5680	2843	34948384
Foetal cardiac arrest	65.91	24.23	10	5694	21	34951206
Neutropenia	65.17	24.23	102	5602	156676	34794551
Anal inflammation	62.18	24.23	18	5686	1282	34949945
Thrombocytopenia	61.28	24.23	99	5605	156148	34795079
Rash maculo-papular	59.73	24.23	44	5660	28407	34922820
SARS-CoV-2 test negative	52.70	24.23	15	5689	1005	34950222
Systemic mycosis	50.40	24.23	16	5688	1557	34949670
Eosinophilia	47.19	24.23	37	5667	26185	34925042
Hyphaema	46.08	24.23	12	5692	575	34950652
Fatigue	45.90	24.23	4	5700	370649	34580578
Systemic candida	43.62	24.23	18	5686	3708	34947519
Septic shock	40.37	24.23	54	5650	71780	34879447
Febrile neutropenia	39.67	24.23	76	5628	136773	34814454
Accident	38.37	24.23	18	5686	5029	34946198
Cytomegalovirus infection	36.83	24.23	32	5672	26103	34925124
Stevens-Johnson syndrome	35.05	24.23	27	5677	18612	34932615
Geotrichum infection	33.35	24.23	9	5695	495	34950732
Drug resistance	33.06	24.23	30	5674	25897	34925330
Acute kidney injury	32.32	24.23	116	5588	304872	34646355
Thrombotic microangiopathy	30.66	24.23	20	5684	10610	34940617
Haemophagocytic lymphohistiocytosis	29.34	24.23	21	5683	12952	34938275
Renal impairment	29.23	24.23	54	5650	94459	34856768
Coagulation time prolonged	28.74	24.23	10	5694	1292	34949935
Cellulitis	28.50	24.23	39	5665	52912	34898315
Body temperature increased	28.03	24.23	23	5681	17345	34933882
Brain abscess	26.42	24.23	12	5692	3113	34948114
COVID-19 pneumonia	26.40	24.23	22	5682	16945	34934282
C-reactive protein increased	26.37	24.23	38	5666	54060	34897167
Death	25.37	24.23	17	5687	398032	34553195
Mast cell degranulation present	25.21	24.23	5	5699	68	34951159
Respiratory gas exchange disorder	24.65	24.23	7	5697	465	34950762
Flavobacterium infection	24.40	24.23	5	5699	81	34951146

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms	339.58	22.95	164	9830	64080	79670314
Pyrexia	185.15	22.95	315	9679	678394	79056000
Thrombocytopenia	146.58	22.95	173	9821	265086	79469308
Multiple organ dysfunction syndrome	132.24	22.95	114	9880	120132	79614262
Cross sensitivity reaction	125.45	22.95	37	9957	3675	79730719
Neutropenia	119.78	22.95	163	9831	287547	79446847
Rash maculo-papular	107.46	22.95	74	9920	56004	79678390
Acinetobacter infection	104.09	22.95	30	9964	2747	79731647
Septic shock	101.02	22.95	99	9895	122702	79611692
Eosinophilia	89.62	22.95	61	9933	45284	79689110
Anaphylactic reaction	81.23	22.95	74	9920	83669	79650725
Stenotrophomonas infection	78.69	22.95	26	9968	3747	79730647
Febrile neutropenia	74.34	22.95	116	9878	230883	79503511
Drug resistance	72.24	22.95	52	9942	42161	79692233
Venoocclusive disease	69.99	22.95	25	9969	4548	79729846
Fatigue	65.39	22.95	18	9976	929709	78804685
Systemic mycosis	62.19	22.95	20	9974	2646	79731748
Enterococcal infection	62.15	22.95	33	9961	15627	79718767
Anal inflammation	60.58	22.95	17	9977	1413	79732981
Geotrichum infection	52.42	22.95	14	9980	967	79733427
Sepsis	51.61	22.95	108	9886	269320	79465074
Pancytopenia	51.56	22.95	82	9912	165663	79568731
Acute kidney injury	51.27	22.95	162	9832	519242	79215152
Renal impairment	50.37	22.95	79	9915	157704	79576690
SARS-CoV-2 test negative	47.79	22.95	14	9980	1357	79733037
Systemic candida	44.25	22.95	20	9974	6686	79727708
Hyphaema	44.07	22.95	12	9982	892	79733502
Stevens-Johnson syndrome	42.70	22.95	37	9957	39129	79695265
Toxic skin eruption	41.68	22.95	29	9965	22264	79712130
Fall	41.34	22.95	6	9988	487623	79246771
Dizziness	41.27	22.95	8	9986	526433	79207961
Fungaemia	41.15	22.95	17	9977	4574	79729820
Haemodynamic instability	40.67	22.95	26	9968	17356	79717038
C-reactive protein increased	40.33	22.95	64	9930	128963	79605431
Off label use	40.16	22.95	221	9773	906994	78827400
Haemophagocytic lymphohistiocytosis	39.88	22.95	28	9966	21809	79712585
Mental status changes postoperative	38.78	22.95	8	9986	177	79734217
Cytomegalovirus infection	38.06	22.95	36	9958	42608	79691786
Klebsiella infection	37.99	22.95	24	9970	15696	79718698
Confusion postoperative	37.32	22.95	8	9986	214	79734180
Acute generalised exanthematous pustulosis	35.95	22.95	24	9970	17230	79717164
Toxic epidermal necrolysis	34.85	22.95	35	9959	44546	79689848
Dyspnoea	34.57	22.95	34	9960	856991	78877403
Cholestasis	33.75	22.95	37	9957	52072	79682322
Weight decreased	33.51	22.95	3	9991	355195	79379199
Drug ineffective	33.28	22.95	240	9754	1080673	78653721
Morganella infection	32.75	22.95	10	9984	1117	79733277
Haemostasis	32.59	22.95	8	9986	394	79734000
Headache	32.53	22.95	21	9973	653751	79080643
Pathogen resistance	32.44	22.95	21	9973	14321	79720073
Accident	30.56	22.95	17	9977	8814	79725580
Thrombotic microangiopathy	30.34	22.95	23	9971	20146	79714248
Fungal infection	29.42	22.95	31	9963	41717	79692677
Staphylococcal infection	28.76	22.95	36	9958	58259	79676135
Cellulitis	28.58	22.95	50	9944	109010	79625384
Disseminated mucormycosis	27.67	22.95	8	9986	740	79733654
Mast cell degranulation present	26.53	22.95	5	9989	68	79734326
Hyperbilirubinaemia	26.39	22.95	23	9971	24495	79709899
Asthenia	26.03	22.95	16	9978	511673	79222721
Coagulation time prolonged	24.97	22.95	10	9984	2485	79731909
Flavobacterium infection	24.81	22.95	5	9989	98	79734296
Fusarium infection	24.25	22.95	9	9985	1823	79732571
Brain abscess	24.21	22.95	12	9982	4924	79729470
Bronchopulmonary aspergillosis	24.17	22.95	21	9973	22273	79712121
Platelet count decreased	24.17	22.95	66	9928	194598	79539796
Pain in extremity	23.82	22.95	8	9986	364530	79369864
Dermatitis bullous	23.11	22.95	17	9977	14228	79720166

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01XA02	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Glycopeptide antibacterials
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:36047	antibacterial drugs
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Staphylococcal infectious disease	indication	56038003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4025272	VUID
N0000171799	NUI
D02142	KEGG_DRUG
4025272	VANDF
C0145106	UMLSCUI
CHEBI:29687	CHEBI
CHEMBL4297166	ChEMBL_ID
CHEMBL2367892	ChEMBL_ID
D017334	MESH_DESCRIPTOR_UI
DB06149	DRUGBANK_ID
10924	IUPHAR_LIGAND_ID
5155	INN_ID
4U3D3YY81M	UNII
133065662	PUBCHEM_CID
196469	RXNORM
003765	NDDF
387529008	SNOMEDCT_US
96014005	SNOMEDCT_US

Pharmaceutical products:

None