sulfalene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2517 152-47-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulphamethopyrazine
  • sulfamethopyrazine
  • sulfamethoxypyrazine
  • sulfametopyrazine
  • sulfapyrazinemethoxine
  • sulfapyrazinemethoxyine
  • sulfapyrazinemethoxyne
  • sulfalene
Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
  • Molecular weight: 280.30
  • Formula: C11H12N4O3S
  • CLOGP: 1.15
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 107.20
  • ALOGS: -2.84
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.808 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.791 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 15.136 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.803 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 40.010 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 37.280 % High 1
herg hERG pIC50 3.897 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.791 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.062 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 21.050 % High 1
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GRK3,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK 41
kinase-selectivity-class ACVR2A,AURKA,AXL,CDK9,DDR1,DYRK1B,ERBB2,GRK2,MAP2K3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK7,PDK4,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 23
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.438 High 1
mh-clint Mouse hepatocyte intrinsic clearance 1.469 High 1
mppb Mouse plasma protein binding (% unbound) 54.140 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.061 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 41.840 % High 1
rh-clint Rat hepatocyte intrinsic clearance 0.798 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.730 % High 1
rppb Rat plasma protein binding (% unbound) 16.410 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 926.830 uM High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
ATC P01BF04 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:38068 antimalarial

Related Drugs by ATC class:

J01ED Long-acting sulfonamides 8 drugs
sulfadimethoxinesulfamazonesulfamerazinesulfametersulfamethoxypyridazinesulfametomidinesulfaperinsulfaphenazole
P01BF Artemisinin and derivatives, combinations 11 drugs
amodiaquineartemetherartemisininartenimolartesunatelumefantrinemefloquinepiperaquinepyrimethaminepyronaridinesulfadoxine

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.4 acidic
pKa2 2.39 Basic
pKa3 1.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
N0000166861 NUI
D01216 KEGG_DRUG
C0038683 UMLSCUI
CHEBI:32162 CHEBI
CHEMBL1525826 ChEMBL_ID
DB00664 DRUGBANK_ID
10174 IUPHAR_LIGAND_ID
1209 INN_ID
T6BL4ZC15G UNII
9047 PUBCHEM_CID
10175 RXNORM
004041 NDDF
324407006 SNOMEDCT_US
395890008 SNOMEDCT_US
D013415 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None