artenimol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antimalarial agents, artemisinin related compounds 4194 71939-50-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dihydroartemisinin
  • dihydroartemisinine
  • dihydroqinghaosu
  • alaxin
  • cotecxin
  • cotexin
  • beta-Dihydroartemisinin
  • artenimol
Artenimol is able to reach high concentrations within the parasitized erythrocytes. Its endoperoxide bridge is thought to be essential for its antimalarial activity, causing free-radical damage to parasite membrane systems.
  • Molecular weight: 284.35
  • Formula: C15H24O5
  • CLOGP: 2.45
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 57.15
  • ALOGS: -1.95
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.28 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 27, 2011 EMA Sigma-Tau Industrie Farmaceutiche Riunite S.p.A

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemolytic anaemia 79.08 71.64 12 23 9830 46676197

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC P01BE05 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, plain
ATC P01BF05 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Malaria indication 61462000 DOID:12365

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.52 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
6A9O50735X UNII
D07362 KEGG_DRUG
C2828299 UMLSCUI
CHEBI:135921 CHEBI
CHEMBL252518 ChEMBL_ID
DB11638 DRUGBANK_ID
456410 PUBCHEM_CID
7777 INN_ID
C039060 MESH_SUPPLEMENTAL_RECORD_UI
9957 IUPHAR_LIGAND_ID
014244 NDDF
713474002 SNOMEDCT_US

Pharmaceutical products:

None