sulfameter Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2511 651-06-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfamethoxydiazine
  • methoxypyrimal
  • sulfameter
  • sulfamethoxine
  • sulfamethoxydin
  • sulfamethoxypyrimidine
  • sulfametin
  • sulfametorine
  • sulfametoxydiazine
  • sulphamethoxydiazine
Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections.
  • Molecular weight: 280.30
  • Formula: C11H12N4O3S
  • CLOGP: 0.65
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 107.20
  • ALOGS: -2.95
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 76.45 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D007917 Leprostatic Agents
CHEBI has role CHEBI:35441 anti-infective drugs
CHEBI has role CHEBI:35816 leprostatic
CHEBI has role CHEBI:35846 renal agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.04 acidic
pKa2 2.22 Basic
pKa3 1.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D02517 KEGG_DRUG
C0038685 UMLSCUI
CHEBI:53727 CHEBI
CHEMBL1200359 ChEMBL_ID
D013417 MESH_DESCRIPTOR_UI
1335 INN_ID
DB06821 DRUGBANK_ID
3L179F09D6 UNII
5326 PUBCHEM_CID
002831 NDDF
16106007 SNOMEDCT_US

Pharmaceutical products:

None