sulfameter ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2511 651-06-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfamethoxydiazine
  • methoxypyrimal
  • sulfameter
  • sulfamethoxine
  • sulfamethoxydin
  • sulfamethoxypyrimidine
  • sulfametin
  • sulfametorine
  • sulfametoxydiazine
  • sulphamethoxydiazine
Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections.
  • Molecular weight: 280.30
  • Formula: C11H12N4O3S
  • CLOGP: 0.65
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 107.20
  • ALOGS: -2.95
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 76.45 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
July 1, 1966 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D007917 Leprostatic Agents
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35816 leprostatic drugs
CHEBI has role CHEBI:35846 renal agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.04 acidic
pKa2 2.22 Basic
pKa3 1.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D02517 KEGG_DRUG
CHEBI:53727 CHEBI
CHEMBL1200359 ChEMBL_ID
1335 INN_ID
DB06821 DRUGBANK_ID
3L179F09D6 UNII
5326 PUBCHEM_CID
002831 NDDF
16106007 SNOMEDCT_US
D013417 MESH_DESCRIPTOR_UI
C0038685 UMLSCUI

Pharmaceutical products:

None