lumefantrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1617 82186-77-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lumefantrine
  • benflumelol
  • benflumetol
Lumefantrine is an antimalarial agent. Available data suggest lumefantrine inhibits the formation of beta-hematin by forming a complex with hemin.
  • Molecular weight: 528.94
  • Formula: C30H32Cl3NO
  • CLOGP: 10.20
  • LIPINSKI: 2
  • HAC: 2
  • HDO: 1
  • TPSA: 23.47
  • ALOGS: -7.23
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.28 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 25 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CAMK2G,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FLT3,GAK,GRK2,GSK3B,INSR,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K10,MAP3K21,MAP3K7,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PRKCD,PRKCZ,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,TYRO3,ULK1,ULK2,ZAP70 82
kinase-selectivity-class AXL,EIF2AK3,EPHB4,GRK2,MAPK7,PDK4,SIK2,STK33,TTK 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1

Approvals:

DateAgencyCompanyOrphan
April 7, 2009 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BF01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
FDA EPC N0000175482 Antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:64946 anti-HIV agent

Related Drugs by ATC class:

P01BF Artemisinin and derivatives, combinations 11 drugs
amodiaquineartemetherartemisininartenimolartesunatemefloquinepiperaquinepyrimethaminepyronaridinesulfadoxinesulfalene

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Falciparum malaria indication 62676009 DOID:14067
Torsades de pointes contraindication 31722008
Hypokalemia contraindication 43339004
Bradycardia contraindication 48867003
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.94 acidic
pKa2 8.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.09 CHEMBL

External reference:

IDSource
4028722 VUID
N0000178418 NUI
D03821 KEGG_DRUG
4028722 VANDF
C0531104 UMLSCUI
CHEBI:156095 CHEBI
CHEMBL38827 ChEMBL_ID
D000078102 MESH_DESCRIPTOR_UI
DB06708 DRUGBANK_ID
9969 IUPHAR_LIGAND_ID
7610 INN_ID
F38R0JR742 UNII
6437380 PUBCHEM_CID
847728 RXNORM
18118 MMSL
d05144 MMSL
009715 NDDF
420307001 SNOMEDCT_US
421180001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COARTEM HUMAN PRESCRIPTION DRUG LABEL 2 0078-0568 TABLET 120 mg ORAL NDA 28 sections
COARTEM HUMAN PRESCRIPTION DRUG LABEL 2 76413-154 TABLET 120 mg ORAL NDA 27 sections