sulfamethoxypyridazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2515 80-35-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfamethoxypyridazine
  • spofadazine
  • sulfalex
  • sulfapiridazin
  • sulfapyridazine
  • sulfdurazin
  • sulphamethoxypyridazine
A sulfanilamide antibacterial agent.
  • Molecular weight: 280.30
  • Formula: C11H12N4O3S
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 107.20
  • ALOGS: -2.94
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 47
kinase-selectivity-class ACVR2A,AURKA,AXL,CDK9,DDR1,DYRK1B,ERBB2,GRK2,JAK1,MAP2K3,MAP2K6,MAP4K1,MAPK7,MARK4,PDK4,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 23
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1960 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:50502 EC 2.5.1.15 (dihydropteroate synthase) inhibitor
CHEBI has role CHEBI:88188 drug allergen

Related Drugs by ATC class:

J01ED Long-acting sulfonamides 8 drugs
sulfadimethoxinesulfalenesulfamazonesulfamerazinesulfametersulfametomidinesulfaperinsulfaphenazole

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.27 acidic
pKa2 2.21 Basic
pKa3 1.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000166869 NUI
D02439 KEGG_DRUG
C0038693 UMLSCUI
CHEBI:102516 CHEBI
CHEMBL268869 ChEMBL_ID
DB13773 DRUGBANK_ID
D013421 MESH_DESCRIPTOR_UI
5330 PUBCHEM_CID
12686 IUPHAR_LIGAND_ID
780 INN_ID
T034E4NS2Z UNII
10181 RXNORM
002824 NDDF
420382009 SNOMEDCT_US
421353001 SNOMEDCT_US

Pharmaceutical products:

None