artemisinin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antimalarial agents, artemisinin related compounds 3871 63968-64-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • artemisinin
  • (+)-Artemisinin
  • arteannuin
  • artemef
  • artemisine
  • artemisinine
antimalarial from Chinese medicinal herb Artemisia annua
  • Molecular weight: 282.34
  • Formula: C15H22O5
  • CLOGP: 2.72
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 53.99
  • ALOGS: -2.35
  • ROTB: 0

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BE01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, plain
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:76924 plant metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Falciparum malaria indication 62676009 DOID:14067

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 1A2 Enzyme IC50 5.70 DRUG MATRIX

External reference:

IDSource
9RMU91N5K2 UNII
D02481 KEGG_DRUG
C0052430 UMLSCUI
CHEBI:223316 CHEBI
CHEMBL567597 ChEMBL_ID
68827 PUBCHEM_CID
DB13132 DRUGBANK_ID
5954 INN_ID
C031327 MESH_SUPPLEMENTAL_RECORD_UI
9954 IUPHAR_LIGAND_ID
2367409 RXNORM
895350006 SNOMEDCT_US
96106001 SNOMEDCT_US

Pharmaceutical products:

None