artemisinin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antimalarial agents, artemisinin related compounds 3871 63968-64-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • artemisinin
  • (+)-Artemisinin
  • arteannuin
  • artemef
  • artemisine
  • artemisinine
antimalarial from Chinese medicinal herb Artemisia annua
  • Molecular weight: 282.34
  • Formula: C15H22O5
  • CLOGP: 2.34
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 53.99
  • ALOGS: -2.35
  • ROTB: 0

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

PropertyValueReference
S (Water solubility) 0.05 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BE01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, plain
ATC P01BF07 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
ATC P01BF08 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Falciparum malaria indication 62676009 DOID:14067




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 1A2 Enzyme IC50 5.70 DRUG MATRIX

External reference:

IDSource
D02481 KEGG_DRUG
C0052430 UMLSCUI
CHEBI:223316 CHEBI
CHEMBL567597 ChEMBL_ID
DB13132 DRUGBANK_ID
C031327 MESH_SUPPLEMENTAL_RECORD_UI
68827 PUBCHEM_CID
9954 IUPHAR_LIGAND_ID
5954 INN_ID
9RMU91N5K2 UNII
2367409 RXNORM
019140 NDDF
895350006 SNOMEDCT_US
96106001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ArtemiC Rescue HUMAN OTC DRUG LABEL 4 83278-001 SPRAY, SUSPENSION 0.60 g ORAL unapproved drug other 11 sections