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sulfadimethoxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-infectives, sulfonamides | 2501 | 122-11-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sulfanilamide that is used as an anti-infective agent.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 59.10 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK | 46 | |||
| kinase-selectivity-class | ACVR2A,AURKA,AXL,CDK16,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,JAK1,MAP2K3,MAP2K6,MAP3K21,MAP4K1,MAPK7,MARK4,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 25 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01ED01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Long-acting sulfonamides |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:88188 | drug allergen |
Related Drugs by ATC class:
J01ED Long-acting sulfonamides 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Respiratory genitourinary tract infections caused by Streptococci | Indication |
| Cats | Respiratory genitourinary tract infections caused by Staphylococci | Indication |
| Cats | Respiratory genitourinary tract infections caused by Escherichia | Indication |
| Cats | Respiratory genitourinary tract infections caused by Salmonella | Indication |
| Cats | Respiratory genitourinary tract infections caused by Klebsiella | Indication |
| Cats | Respiratory genitourinary tract infections caused by Proteus | Indication |
| Cats | Respiratory genitourinary tract infections caused by Shigella | Indication |
| Cats | Enteric infections caused by Streptococci | Indication |
| Cats | Enteric infections caused by Staphylococci | Indication |
| Cats | Enteric infections caused by Escherichia | Indication |
| Cats | Enteric infections caused by Salmonella | Indication |
| Cats | Enteric infections caused by Klebsiella | Indication |
| Cats | Enteric infections caused by Proteus | Indication |
| Cats | Enteric infections caused by Shigella | Indication |
| Cats | Soft tissue infections infections caused by Streptococci | Indication |
| Cats | Soft tissue infections infections caused by Staphylococci | Indication |
| Cats | Soft tissue infections infections caused by Escherichia | Indication |
| Cats | Soft tissue infections infections caused by Salmonella | Indication |
| Cats | Soft tissue infections infections caused by Klebsiella | Indication |
| Cats | Soft tissue infections infections caused by Proteus | Indication |
| Cats | Soft tissue infections infections caused by Shigella | Indication |
| Cats | Bacterial enteritis associated with coccidiosis | Indication |
| Cats | Bacterial enteritis associated with Salmonellosis | Indication |
| Cattle | Shipping fever complex | Indication |
| Cattle | Bacterial pneumonia associated with Pasteurella spp | Indication |
| Cattle | Diphtheria | Indication |
| Cattle | Necrotic pododermatitis (foot rot) caused by Fusobacterium necrophorum | Indication |
| Chickens | Coccidiosis | Indication |
| Chickens | Cholera | Indication |
| Chickens | Coryza | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Streptococci | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Staphylococci | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Escherichia | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Salmonella | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Klebsiella | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Proteus | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Shigella | Indication |
| Dogs | Enteric infections caused by Streptococci | Indication |
| Dogs | Enteric infections caused by Staphylococci | Indication |
| Dogs | Enteric infections caused by Escherichia | Indication |
| Dogs | Enteric infections caused by Salmonella | Indication |
| Dogs | Enteric infections caused by Klebsiella | Indication |
| Dogs | Enteric infections caused by Proteus | Indication |
| Dogs | Enteric infections caused by Shigella | Indication |
| Dogs | Soft tissue infections infections caused by Streptococci | Indication |
| Dogs | Soft tissue infections infections caused by Staphylococci | Indication |
| Dogs | Soft tissue infections infections caused by Escherichia | Indication |
| Dogs | Soft tissue infections infections caused by Salmonella | Indication |
| Dogs | Soft tissue infections infections caused by Klebsiella | Indication |
| Dogs | Soft tissue infections infections caused by Proteus | Indication |
| Dogs | Soft tissue infections infections caused by Shigella | Indication |
| Dogs | Bacterial enteritis associated with coccidiosis | Indication |
| Dogs | Bacterial enteritis associated with Salmonellosis | Indication |
| Horses | Respiratory disease caused by Streptococcus equi (strangles) | Indication |
| Turkeys | Coccidiosis | Indication |
| Turkeys | Cholera | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Bactrovet Tablets 250 mg | Intervet Inc. | 1 |
| Albon Tablets | Zoetis Inc. | 1 |
| AGRIBON Concentrated Solution 12.5%, ALBON Concentrated Solution 12.5% | Zoetis Inc. | 1 |
| Albon, Agribon Boluses - 2.5, Agribon Boluses - 5.0, Agribon Boluses - 15.0 | Zoetis Inc. | 1 |
| Bactrovet Oral Suspension 12.5% | Intervet Inc. | 1 |
| Rofenaid 40 | Zoetis Inc. | 2 |
| Agribon Injection 40%, Albon | Zoetis Inc. | 1 |
| Albon Oral Suspension 5% | Zoetis Inc. | 1 |
| Albon | Zoetis Inc. | 1 |
| Albon S.R. (Sustained Release) | Zoetis Inc. | 1 |
| Medacide-SDM Injection 10% | Cronus Pharma Specialities India Private Limited | 1 |
| Primor Tablets | Zoetis Inc. | 2 |
| Romet-30 | Pharmaq AS | 2 |
| DI-METHOX | Huvepharma EOOD | 1 |
| DI-METHOX | Huvepharma EOOD | 1 |
| Di-Methox Injection 40%, Sulfadimethoxine Injection 40% | Huvepharma EOOD | 1 |
| Sulfadimethoxine Concentrated Solution 12.5% | Cronus Pharma Specialities India Private Limited | 1 |
| Sulfadimethoxine Injection 40% | Huvepharma EOOD | 1 |
| Sulfadimethoxine 12.5% Oral Solution | Huvepharma EOOD | 1 |
| Sulfasol Soluble Powder | Med-Pharmex Inc. | 1 |
| Sulforal | Med-Pharmex Inc. | 1 |
| Sulfadimethoxine Soluble Powder | Phibro Animal Health Corp. | 1 |
| Sulfamed-G | Bimeda Animal Health Limited | 1 |
| Sulfadimethoxine Soluble Powder | First Priority Inc. | 1 |
| SulfaMed | Bimeda Animal Health Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.93 | acidic |
| pKa2 | 1.99 | Basic |
| pKa3 | 0.4 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.21 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| N0000166864 | NUI |
| D01142 | KEGG_DRUG |
| C0038676 | UMLSCUI |
| CHEBI:32161 | CHEBI |
| CHEMBL62193 | ChEMBL_ID |
| DB06150 | DRUGBANK_ID |
| D013412 | MESH_DESCRIPTOR_UI |
| 5323 | PUBCHEM_CID |
| 12638 | IUPHAR_LIGAND_ID |
| 840 | INN_ID |
| 30CPC5LDEX | UNII |
| 10172 | RXNORM |
| 002825 | NDDF |
| 387279005 | SNOMEDCT_US |
| 51013009 | SNOMEDCT_US |
Pharmaceutical products:
None