artesunate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antimalarial agents, artemisinin related compounds 247 88495-63-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • artesunate
  • arinate
  • arsuamoon
  • arsumax
  • artesunic acid
  • cosunate
  • dihydroqinghasu hemsuccinate
  • artesunate amivas
A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities. Artesunate (AS) contains an endoperoxide bridge that is activated by heme iron, resulting in the generation of free radicals that alkylate parasite proteins and ultimately lead to cell death. Dihydroartemisinin (DHA, also known as artenimol), the active metabolite of artesunate, was found to specifically increase oxidative stress in P. falciparum-infected erythrocytes but not uninfected cells, by reduction of antioxidants.
  • Molecular weight: 384.43
  • Formula: C19H28O8
  • CLOGP: 2.93
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 100.52
  • ALOGS: -2.75
  • ROTB: 5
  • Status: ONP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.28 g O
0.28 g P
0.28 g R

ADMET properties:

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

None

External reference:

Pharmaceutical products:

None

artesunate