sulfaphenazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2523 526-08-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfaphenazole
  • sulfabid
  • sulfaphenazol
  • sulfaphenazon
  • sulfaphenylpyrazole
  • sulphaphenazole
  • sulfafenazol
A sulfonilamide anti-infective agent.
  • Molecular weight: 314.36
  • Formula: C15H14N4O2S
  • CLOGP: 2.07
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 90.01
  • ALOGS: -3.05
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 2, 1974 FDA PURDUE FREDERICK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
ATC S01AB05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Sulfonamides
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50183 cytochrome P450 inhibitor
CHEBI has role CHEBI:77781 13-deoxydaunorubicin hydroxylase inhibitor
CHEBI has role CHEBI:77783 quinine 3-monooxygenase (EC 1.14.13.67) inhibitor

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.61 acidic
pKa2 1.87 Basic
pKa3 0.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 6.70 DRUG MATRIX
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D01954 KEGG_DRUG
C0038706 UMLSCUI
CHEBI:77780 CHEBI
CHEMBL1109 ChEMBL_ID
DB06729 DRUGBANK_ID
D013426 MESH_DESCRIPTOR_UI
5335 PUBCHEM_CID
11352 IUPHAR_LIGAND_ID
912 INN_ID
0J8L4V3F81 UNII
002828 NDDF
51569009 SNOMEDCT_US

Pharmaceutical products:

None