sulfaphenazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2523 526-08-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfaphenazole
  • sulfabid
  • sulfaphenazol
  • sulfaphenazon
  • sulfaphenylpyrazole
  • sulphaphenazole
  • sulfafenazol
A sulfonilamide anti-infective agent.
  • Molecular weight: 314.36
  • Formula: C15H14N4O2S
  • CLOGP: 2.07
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 90.01
  • ALOGS: -3.05
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

PropertyValueReference
S (Water solubility) 1.50 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
April 2, 1974 FDA PURDUE FREDERICK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
ATC S01AB05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Sulfonamides
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50183 P450 inhibitors
CHEBI has role CHEBI:77781 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) inhibitor
CHEBI has role CHEBI:77783 quinine 3-monooxygenase inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.61 acidic
pKa2 1.87 Basic
pKa3 0.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 6.70 DRUG MATRIX
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D01954 KEGG_DRUG
C0038706 UMLSCUI
CHEBI:77780 CHEBI
CHEMBL1109 ChEMBL_ID
DB06729 DRUGBANK_ID
D013426 MESH_DESCRIPTOR_UI
5335 PUBCHEM_CID
11352 IUPHAR_LIGAND_ID
912 INN_ID
0J8L4V3F81 UNII
002828 NDDF
51569009 SNOMEDCT_US

Pharmaceutical products:

None