prednisone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2253 53-03-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednisone anhydrous
  • prednisone
  • 1,2-dehydrocortisone
  • dehydrocortisone
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
  • Molecular weight: 358.43
  • Formula: C21H26O5
  • CLOGP: 1.66
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 91.67
  • ALOGS: -3.51
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.12 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.97 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.57 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.27 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.90 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.322 Moderate 0.68
caco2-efflux Caco-2 efflux ratio (BA/AB) 11.614 Moderate 0.68
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 21.928 10^-6 cm/s Moderate 0.68
dh-clint Dog hepatocyte intrinsic clearance 9.120 uL/min/10^6 cells Moderate 0.68
dppb Dog plasma protein binding (% unbound) 39.780 % Moderate 0.68
fcs-ppb Fetal calf serum protein binding (% unbound) 58.720 % Moderate 0.68
herg hERG pIC50 4.355 pIC50 Moderate 0.68
hh-clint Human hepatocyte intrinsic clearance 12.972 uL/min/10^6 cells Moderate 0.68
hlm-clint Human liver microsomal intrinsic clearance 15.205 uL/min/mg protein Moderate 0.68
hppb Human plasma protein binding (% unbound) 29.710 % Moderate 0.68
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,TEK 21
kinase-selectivity-class AXL,GRK2,MAP2K6,MAP3K14 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 4.285 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 14.454 Moderate 0.68
mh-clint Mouse hepatocyte intrinsic clearance 46.666 Moderate 0.68
mppb Mouse plasma protein binding (% unbound) 39.560 Moderate 0.68
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 30.130 Moderate 0.68
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.68
pppb Pig plasma protein binding (% unbound) 55.790 % Moderate 0.68
rat-kpuu-brain Rat brain Kpuu 0.056 % High 1
rh-clint Rat hepatocyte intrinsic clearance 55.719 uL/min/10^6 cells Moderate 0.68
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.090 % Moderate 0.68
rppb Rat plasma protein binding (% unbound) 28.240 % Moderate 0.68
solubility-dd Solubility at pH 7.4 in DMSO 584.790 uM Moderate 0.68

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 1955 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1766.45 10.66 27761 1220454 1356537 88023695
Rheumatoid arthritis 1547.48 10.66 9401 1238814 353213 89027019
Completed suicide 1519.55 10.66 128 1248087 144930 89235302
Toxicity to various agents 1038.57 10.66 1470 1246745 286376 89093856
Death 936.39 10.66 3191 1245024 453360 88926872
Intentional overdose 859.76 10.66 132 1248083 93702 89286530
Off label use 709.16 10.66 20018 1228197 1082234 88297998
Overdose 706.77 10.66 677 1247538 157032 89223200
Post transplant lymphoproliferative disorder 698.70 10.66 654 1247561 6295 89373937
Drug abuse 659.23 10.66 161 1248054 82186 89298046
Constipation 642.40 10.66 1863 1246352 278532 89101700
Joint swelling 625.15 10.66 10067 1238148 493233 88886999
Drug interaction 573.06 10.66 1922 1246293 274531 89105701
Contraindicated product administered 561.80 10.66 6810 1241405 313329 89066903
Depressed level of consciousness 545.47 10.66 162 1248053 72622 89307610
Electrocardiogram QT prolonged 536.25 10.66 165 1248050 72291 89307941
Condition aggravated 529.76 10.66 11310 1236905 584235 88795997
Suicide attempt 529.45 10.66 188 1248027 75211 89305021
Treatment failure 519.28 10.66 6433 1241782 297495 89082737
Systemic lupus erythematosus 516.58 10.66 7414 1240801 354482 89025750
Arthralgia 512.74 10.66 14188 1234027 764334 88615898
Hyponatraemia 510.58 10.66 653 1247562 132885 89247347
Asthma 504.17 10.66 5327 1242888 236833 89143399
Colitis ulcerative 501.48 10.66 1897 1246318 58369 89321863
Bradycardia 452.08 10.66 299 1247916 83548 89296684
Hypotension 443.25 10.66 2645 1245570 322752 89057480
Therapeutic product effect incomplete 431.40 10.66 4324 1243891 189572 89190660
Device expulsion 425.49 10.66 37 1248178 40849 89339383
Malignant neoplasm progression 415.40 10.66 516 1247699 106354 89273878
Nausea 412.81 10.66 11898 1236317 1098418 88281814
Pemphigus 408.88 10.66 6548 1241667 320316 89059916
Acute kidney injury 406.01 10.66 2663 1245552 317724 89062508
Arthropathy 403.85 10.66 7188 1241027 359054 89021178
Histoplasmosis disseminated 398.85 10.66 297 1247918 2008 89378224
Pain 394.98 10.66 17123 1231092 979218 88401014
Fall 393.38 10.66 4491 1243724 477319 88902913
Therapeutic product effect decreased 390.04 10.66 5672 1242543 271899 89108333
Loss of personal independence in daily activities 384.41 10.66 3196 1245019 132909 89247323
Swelling 369.59 10.66 7951 1240264 411107 88969125
Seizure 367.92 10.66 989 1247226 151640 89228592
Dizziness 348.91 10.66 5862 1242353 583422 88796810
Somnolence 344.20 10.66 1593 1246622 207491 89172741
White blood cell count decreased 338.45 10.66 1173 1247042 165936 89214296
Obstructive airways disorder 332.24 10.66 944 1247271 24925 89355307
Drug intolerance 328.57 10.66 8278 1239937 439313 88940919
Drug effective for unapproved indication 315.55 10.66 463 1247752 7455 89372777
Cognitive disorder 314.27 10.66 295 1247920 69112 89311120
Anaemia 309.90 10.66 3233 1244982 349569 89030663
Sedation 308.88 10.66 138 1248077 48033 89332199
Wheezing 308.32 10.66 4798 1243417 233282 89146950
Nocardiosis 303.90 10.66 265 1247950 2305 89377927
Hypoglycaemia 301.12 10.66 310 1247905 69538 89310694
Glossodynia 298.66 10.66 6152 1242063 315627 89064605
Epstein-Barr virus infection 298.37 10.66 522 1247693 9822 89370410
Cardiac arrest 291.59 10.66 631 1247584 104304 89275928
Transplant rejection 283.63 10.66 576 1247639 12182 89368050
Disease recurrence 280.64 10.66 1145 1247070 36508 89343724
Intentional self-injury 278.62 10.66 37 1248178 29297 89350935
Rhabdomyolysis 277.35 10.66 182 1248033 51074 89329158
Pneumocystis jirovecii pneumonia 275.85 10.66 787 1247428 20829 89359403
Dehydration 273.38 10.66 1564 1246651 192883 89187349
Hand deformity 272.01 10.66 5657 1242558 290705 89089527
Serotonin syndrome 271.96 10.66 91 1248124 37796 89342436
Intentional product misuse 271.87 10.66 512 1247703 89092 89291140
Synovitis 269.14 10.66 6189 1242026 323563 89056669
Cytomegalovirus infection 268.18 10.66 892 1247323 25710 89354522
Cardio-respiratory arrest 264.60 10.66 287 1247928 62853 89317379
Neutrophil count decreased 263.94 10.66 359 1247856 71173 89309059
Orthostatic hypotension 263.24 10.66 123 1248092 41704 89338528
Suicidal ideation 251.56 10.66 392 1247823 73463 89306769
Full blood count abnormal 250.25 10.66 1084 1247131 35513 89344719
Rebound effect 249.47 10.66 457 1247758 8927 89371305
Aspergillus infection 249.40 10.66 496 1247719 10327 89369905
Abdominal discomfort 246.94 10.66 8451 1239764 468877 88911355
Vomiting 242.12 10.66 8655 1239560 779638 88600594
Loss of consciousness 233.97 10.66 1063 1247152 139175 89241057
Smooth muscle cell neoplasm 233.31 10.66 175 1248040 1198 89379034
Polyomavirus-associated nephropathy 232.56 10.66 225 1247990 2265 89377967
Hallucination 229.55 10.66 345 1247870 65614 89314618
Cytomegalovirus viraemia 224.26 10.66 387 1247828 7199 89373033
Decreased appetite 224.00 10.66 3741 1244474 372799 89007433
Hypokalaemia 222.85 10.66 987 1247228 130129 89250103
Musculoskeletal stiffness 222.56 10.66 5502 1242713 291030 89089202
Alopecia 220.71 10.66 8620 1239595 486451 88893781
Metabolic acidosis 220.35 10.66 265 1247950 55411 89324821
Hepatic function abnormal 220.03 10.66 188 1248027 46100 89334132
Tremor 218.53 10.66 1226 1246989 151947 89228285
Intentional product use issue 216.20 10.66 4192 1244023 212700 89167532
Hyperkalaemia 214.48 10.66 352 1247863 64612 89315620
Hyperhidrosis 213.44 10.66 1057 1247158 135248 89244984
Balance disorder 210.59 10.66 661 1247554 96419 89283813
Strongyloidiasis 207.40 10.66 174 1248041 1428 89378804
Blood pressure systolic increased 207.24 10.66 1446 1246769 56899 89323333
Lactic acidosis 206.37 10.66 234 1247981 50229 89330003
Blood pressure fluctuation 203.54 10.66 1328 1246887 51085 89329147
Neutropenia 202.65 10.66 2048 1246167 222856 89157376
Product dose omission issue 201.40 10.66 2816 1245399 288871 89091361
Agitation 198.66 10.66 389 1247826 66709 89313523
Kidney transplant rejection 197.89 10.66 287 1247928 4570 89375662
Drug withdrawal syndrome 197.59 10.66 74 1248141 28649 89351583
Diarrhoea 197.16 10.66 10754 1237461 928436 88451796
Palmar-plantar erythrodysaesthesia syndrome 194.79 10.66 71 1248144 27952 89352280
Weight increased 193.33 10.66 7307 1240908 410620 88969612
Wrong technique in product usage process 192.57 10.66 438 1247777 71133 89309099
Syncope 189.14 10.66 1062 1247153 131601 89248631
Cushingoid 185.00 10.66 429 1247786 9966 89370266
Haemophagocytic lymphohistiocytosis 183.03 10.66 548 1247667 14911 89365321
Diffuse large B-cell lymphoma recurrent 182.53 10.66 234 1247981 3292 89376940
Histoplasmosis 179.73 10.66 185 1248030 2019 89378213
Trichodysplasia spinulosa 176.65 10.66 114 1248101 590 89379642
Dyskinesia 176.58 10.66 146 1248069 36388 89343844
Platelet count decreased 176.05 10.66 1133 1247082 135836 89244396
Creatinine renal clearance decreased 174.42 10.66 26 1248189 18873 89361359
Sputum discoloured 173.85 10.66 647 1247568 19744 89360488
Wound 171.03 10.66 5421 1242794 297559 89082673
Blood calcium decreased 170.43 10.66 102 1248113 30080 89350152
Multiple sclerosis relapse 170.26 10.66 286 1247929 52019 89328213
Respiratory arrest 170.00 10.66 126 1248089 33185 89347047
Dry skin 169.76 10.66 631 1247584 87442 89292790
Temperature regulation disorder 167.03 10.66 8 1248207 14571 89365661
Poisoning deliberate 166.01 10.66 17 1248198 16469 89363763
Sopor 165.37 10.66 66 1248149 24578 89355654
Unresponsive to stimuli 163.38 10.66 170 1248045 37951 89342281
Device dislocation 163.38 10.66 117 1248098 31365 89348867
Neuroleptic malignant syndrome 158.89 10.66 13 1248202 15083 89365149
Forced expiratory volume decreased 158.39 10.66 286 1247929 5522 89374710
Infusion related reaction 156.65 10.66 7129 1241086 409651 88970581
Productive cough 155.34 10.66 1685 1246530 75378 89304854
Sinusitis 153.45 10.66 5977 1242238 337111 89043121
Lethargy 152.93 10.66 408 1247807 62731 89317501
Tachycardia 152.46 10.66 1411 1246804 156262 89223970
Discomfort 151.55 10.66 4896 1243319 269439 89110793
Altered state of consciousness 151.18 10.66 127 1248088 31405 89348827
Disturbance in attention 151.12 10.66 260 1247955 46849 89333383
Blood pressure diastolic abnormal 150.07 10.66 607 1247608 19274 89360958
Metastases to liver 148.26 10.66 108 1248107 28699 89351533
Peripheral swelling 148.12 10.66 7033 1241182 406073 88974159
Gastrointestinal haemorrhage 147.57 10.66 689 1247526 89559 89290673
Faecal calprotectin increased 147.26 10.66 225 1247990 3762 89376470
Pericarditis 145.53 10.66 4807 1243408 265344 89114888
Circulatory collapse 142.26 10.66 83 1248132 24821 89355411
Accidental exposure to product 140.36 10.66 229 1247986 42137 89338095
International normalised ratio increased 139.47 10.66 275 1247940 47041 89333191
Infection 135.01 10.66 6189 1242026 355905 89024327
Nasal polyps 134.83 10.66 392 1247823 10488 89369744
Lower respiratory tract infection 133.93 10.66 4456 1243759 246203 89134029
Thrombocytopenia 133.91 10.66 2044 1246171 206681 89173551
Cytomegalovirus colitis 133.49 10.66 197 1248018 3189 89377043
Metastases to bone 133.39 10.66 94 1248121 25411 89354821
Phaeohyphomycosis 133.14 10.66 83 1248132 400 89379832
Cerebrovascular accident 132.99 10.66 1075 1247140 122458 89257774
Coma 132.50 10.66 532 1247683 72100 89308132
Cough 132.13 10.66 6281 1241934 362681 89017551
Anti-cyclic citrullinated peptide antibody positive 131.70 10.66 4224 1243991 232209 89148023
Varicella zoster virus infection 130.97 10.66 210 1248005 3667 89376565
Neuropathy peripheral 130.58 10.66 1230 1246985 135740 89244492
Arthritis 130.06 10.66 3120 1245095 164195 89216037
Product substitution issue 129.69 10.66 43 1248172 17965 89362267
Cardiac failure 129.61 10.66 928 1247287 108568 89271664
Depression 127.92 10.66 3156 1245059 297445 89082787
Poisoning 127.27 10.66 27 1248188 15190 89365042
Device difficult to use 125.94 10.66 42 1248173 17483 89362749
Hypomagnesaemia 124.93 10.66 185 1248030 35403 89344829
Dysgeusia 122.54 10.66 346 1247869 52214 89328018
Cryptococcosis 120.91 10.66 124 1248091 1347 89378885
Mucous stools 119.58 10.66 240 1247975 5031 89375201
Nasopharyngitis 117.22 10.66 6789 1241426 400315 88979917
Epidermodysplasia verruciformis 117.20 10.66 54 1248161 118 89380114
Steroid diabetes 117.07 10.66 158 1248057 2344 89377888
Urinary retention 116.84 10.66 213 1248002 37531 89342701
Blood pressure systolic abnormal 116.78 10.66 555 1247660 18923 89361309
Gastrointestinal disorder 116.63 10.66 4480 1243735 252207 89128025
Meningitis cryptococcal 116.59 10.66 135 1248080 1698 89378534
Steroid dependence 116.55 10.66 150 1248065 2119 89378113
Haematemesis 115.80 10.66 178 1248037 33548 89346684
Red blood cell sedimentation rate abnormal 111.49 10.66 641 1247574 23563 89356669
Dystonia 111.30 10.66 46 1248169 16773 89363459
Respiratory depression 110.76 10.66 38 1248177 15537 89364695
Product use issue 109.86 10.66 5577 1242638 324342 89055890
Melaena 109.84 10.66 194 1248021 34603 89345629
Ill-defined disorder 109.76 10.66 3329 1244886 181562 89198670
Transient ischaemic attack 108.39 10.66 274 1247941 42902 89337330
Osteoporosis 108.38 10.66 1901 1246314 94630 89285602
Inflammation 108.29 10.66 3224 1244991 175368 89204864
Tardive dyskinesia 108.19 10.66 12 1248203 10918 89369314
Parkinsonism 107.77 10.66 30 1248185 14035 89366197
Cardiac failure congestive 107.54 10.66 856 1247359 97838 89282394
Therapy partial responder 106.31 10.66 591 1247624 21452 89358780
Hepatitis B reactivation 106.23 10.66 194 1248021 3780 89376452
Akathisia 106.16 10.66 14 1248201 11145 89369087
Aggression 105.45 10.66 127 1248088 26541 89353691
Epistaxis 104.90 10.66 713 1247502 84412 89295820
Muscle spasms 102.96 10.66 2660 1245555 249223 89131009
Septic shock 102.73 10.66 1680 1246535 82480 89297752
Epstein-Barr virus associated lymphoproliferative disorder 102.04 10.66 153 1248062 2514 89377718
Pulmonary nocardiosis 101.92 10.66 86 1248129 712 89379520
Renal transplant failure 101.44 10.66 100 1248115 1032 89379200
Renal failure 101.25 10.66 1235 1246980 129772 89250460
Cerebral haemorrhage 99.73 10.66 203 1248012 34319 89345913
Blood pressure diastolic decreased 98.89 10.66 671 1247544 26155 89354077
Brain abscess 98.69 10.66 155 1248060 2657 89377575
Foetal exposure during pregnancy 98.64 10.66 285 1247930 42690 89337542
Drug ineffective for unapproved indication 98.26 10.66 1374 1246841 65270 89314962
Full blood count decreased 97.86 10.66 161 1248054 29528 89350704
Hypersensitivity 97.47 10.66 7396 1240819 447281 88932951
Palpitations 97.13 10.66 1312 1246903 135416 89244816
Therapeutic reaction time decreased 97.05 10.66 178 1248037 3480 89376752
Withdrawal syndrome 97.03 10.66 100 1248115 22424 89357808
Drug level below therapeutic 97.02 10.66 234 1247981 5580 89374652
Generalised tonic-clonic seizure 96.83 10.66 210 1248005 34693 89345539
Mydriasis 96.24 10.66 43 1248172 14969 89365263
Polyomavirus viraemia 95.76 10.66 104 1248111 1213 89379019
Inappropriate antidiuretic hormone secretion 95.44 10.66 77 1248138 19428 89360804
Myelosuppression 94.95 10.66 397 1247818 53194 89327038
Fluid retention 94.61 10.66 767 1247448 87324 89292908
Rhinitis allergic 93.98 10.66 469 1247746 16316 89363916
Rash erythematous 93.95 10.66 519 1247696 64585 89315647
Suspected suicide 93.47 10.66 11 1248204 9557 89370675
Product administration error 93.10 10.66 137 1248078 26286 89353946
Rheumatoid nodule 92.84 10.66 534 1247681 19632 89360600
Metastases to central nervous system 92.60 10.66 64 1248151 17478 89362754
Diffuse large B-cell lymphoma 91.73 10.66 295 1247920 8350 89371882
Red blood cell sedimentation rate increased 91.45 10.66 1623 1246592 80972 89299260
Plasma cell myeloma 91.36 10.66 274 1247941 40554 89339678
West Nile viral infection 90.94 10.66 68 1248147 463 89379769
Anxiety 90.88 10.66 3418 1244797 306354 89073878
Vaccination failure 90.32 10.66 97 1248118 1116 89379116
Flushing 89.40 10.66 783 1247432 87708 89292524
Arrhythmia 89.15 10.66 292 1247923 42040 89338192
Breath sounds abnormal 89.06 10.66 434 1247781 14952 89365280
Memory impairment 88.78 10.66 2053 1246162 195191 89185041
Atrial fibrillation 88.56 10.66 1300 1246915 132311 89247921
Labelled drug-drug interaction medication error 88.53 10.66 45 1248170 14537 89365695
Dysarthria 88.44 10.66 417 1247798 54065 89326167
Eye infection toxoplasmal 88.22 10.66 61 1248154 361 89379871
Epstein-Barr viraemia 88.08 10.66 105 1248110 1365 89378867
Complications of transplanted kidney 87.94 10.66 149 1248066 2729 89377503
Disorientation 87.67 10.66 312 1247903 43802 89336430
Haematochezia 87.08 10.66 1417 1246798 69496 89310736
Central nervous system lymphoma 87.03 10.66 124 1248091 1941 89378291
Pulmonary function test abnormal 86.62 10.66 144 1248071 2595 89377637
Restlessness 86.36 10.66 231 1247984 35489 89344743
Exposure to toxic agent 86.30 10.66 6 1248209 7961 89372271
Subdural haematoma 86.19 10.66 62 1248153 16583 89363649
Polymyalgia rheumatica 85.95 10.66 203 1248012 4774 89375458
Blood immunoglobulin E increased 85.86 10.66 189 1248026 4236 89375996
Eosinophilic bronchitis 85.65 10.66 71 1248144 572 89379660
Maternal exposure during pregnancy 85.15 10.66 5904 1242311 354159 89026073
Torsade de pointes 84.75 10.66 52 1248163 15130 89365102
Ascites 84.37 10.66 354 1247861 47386 89332846
Complication of device insertion 84.30 10.66 20 1248195 10416 89369816
Defaecation urgency 84.29 10.66 232 1247983 6010 89374222
Immunosuppressant drug level increased 84.22 10.66 194 1248021 4486 89375746
Muscle rigidity 84.16 10.66 46 1248169 14263 89365969
Blood creatine phosphokinase increased 83.80 10.66 218 1247997 33805 89346427
Therapy non-responder 83.71 10.66 2471 1245744 134233 89245999
Vaginal haemorrhage 83.60 10.66 192 1248023 31079 89349153
Paraesthesia 83.55 10.66 2718 1245497 247608 89132624
Sleep disorder due to a general medical condition 83.23 10.66 963 1247252 43775 89336457
Bronchiectasis 83.18 10.66 560 1247655 21770 89358462
Multiple drug therapy 83.12 10.66 3 1248212 7006 89373226
Vision blurred 82.87 10.66 1046 1247169 109247 89270985
Blood alkaline phosphatase increased 82.82 10.66 360 1247855 47719 89332513
Impaired quality of life 82.41 10.66 574 1247641 22570 89357662
Mycobacterial infection 82.02 10.66 125 1248090 2085 89378147
Heart rate increased 81.93 10.66 2086 1246129 110816 89269416
Accidental overdose 81.89 10.66 166 1248049 28107 89352125
Aspartate aminotransferase increased 81.60 10.66 965 1247250 101972 89278260
Product use in unapproved indication 81.38 10.66 5524 1242691 330712 89049520
Dementia 80.91 10.66 127 1248088 23734 89356498
Delayed graft function 80.84 10.66 99 1248116 1326 89378906
Gamma-glutamyltransferase increased 80.47 10.66 261 1247954 37691 89342541
Neutropenic sepsis 79.80 10.66 79 1248136 18051 89362181
Blood pressure diastolic increased 79.75 10.66 371 1247844 12535 89367697
Stevens-Johnson syndrome 79.64 10.66 179 1248036 29197 89351035
Ventricular tachycardia 79.58 10.66 136 1248079 24572 89355660
Humoral immune defect 79.37 10.66 56 1248159 344 89379888
Oedema peripheral 79.18 10.66 2830 1245385 255085 89125147
Hallucination, visual 79.16 10.66 122 1248093 22970 89357262
Limb deformity 79.05 10.66 176 1248039 3976 89376256
Hepatic cytolysis 78.53 10.66 195 1248020 30721 89349511
Hallucination, auditory 78.24 10.66 63 1248152 15912 89364320
Bronchopulmonary aspergillosis 78.21 10.66 338 1247877 11060 89369172
Alanine aminotransferase increased 77.87 10.66 1153 1247062 117185 89263047
Myocardial infarction 77.77 10.66 1010 1247205 104962 89275270
Hypothermia 76.82 10.66 61 1248154 15514 89364718
Amnesia 76.40 10.66 1043 1247172 107462 89272770
Respiratory tract congestion 75.37 10.66 640 1247575 26770 89353462
Uveitis 75.11 10.66 424 1247791 15479 89364753
Skin ulcer 74.46 10.66 1034 1247181 49041 89331191
Sensitivity to weather change 74.46 10.66 281 1247934 8633 89371599
Sensitisation 73.96 10.66 172 1248043 4003 89376229
Blood glucose increased 73.92 10.66 897 1247318 94349 89285883
Mycobacterium avium complex infection 73.89 10.66 170 1248045 3928 89376304
Deformity 73.85 10.66 348 1247867 11822 89368410
Poor venous access 73.52 10.66 491 1247724 19036 89361196
Epilepsy 73.38 10.66 750 1247465 81456 89298776
Sinus bradycardia 73.32 10.66 75 1248140 16877 89363355
Neoplasm progression 73.09 10.66 339 1247876 44147 89336085
Rheumatoid factor positive 73.04 10.66 2975 1245240 168675 89211557
BK virus infection 72.88 10.66 179 1248036 4319 89375913
Disseminated cryptococcosis 72.79 10.66 70 1248145 699 89379533
Complication associated with device 72.35 10.66 97 1248118 19352 89360880
Adrenal insufficiency 72.19 10.66 679 1247536 29242 89350990
Renal graft infection 71.90 10.66 52 1248163 334 89379898
Ventricular fibrillation 71.82 10.66 53 1248162 13991 89366241
Device issue 71.42 10.66 191 1248024 29346 89350886
Bronchial wall thickening 71.40 10.66 115 1248100 2016 89378216
Restless legs syndrome 71.17 10.66 125 1248090 22345 89357887
Ear pruritus 71.15 10.66 231 1247984 6572 89373660
Delusion 71.08 10.66 52 1248163 13788 89366444
Dissociation 70.08 10.66 6 1248209 6709 89373523
Product quality issue 69.87 10.66 726 1247489 78599 89301633
Anal fissure 69.62 10.66 197 1248018 5188 89375044
Hepatic enzyme increased 69.28 10.66 5819 1242396 354917 89025315
Posterior reversible encephalopathy syndrome 69.23 10.66 536 1247679 21803 89358429
Vasculitis 68.94 10.66 542 1247673 22151 89358081
Impaired healing 68.92 10.66 3914 1244301 230285 89149947
Herpes zoster 68.47 10.66 1748 1246467 92896 89287336
Sarcoidosis 68.32 10.66 310 1247905 10363 89369869
Haematoma 68.10 10.66 291 1247924 38757 89341475
Body temperature increased 68.02 10.66 927 1247288 43783 89336449
Jaundice 67.99 10.66 225 1247990 32292 89347940
Chronic allograft nephropathy 67.96 10.66 69 1248146 740 89379492
Breast cancer metastatic 67.69 10.66 65 1248150 15067 89365165
Atrioventricular block first degree 67.40 10.66 17 1248198 8494 89371738
Klebsiella infection 67.35 10.66 301 1247914 9996 89370236
Joint injury 67.10 10.66 717 1247498 31947 89348285
Pallor 66.99 10.66 243 1247972 33922 89346310
Cerebral infarction 66.59 10.66 169 1248046 26427 89353805
Frequent bowel movements 65.97 10.66 1127 1247088 55808 89324424
Bacillary angiomatosis 65.96 10.66 34 1248181 104 89380128
Blood pressure increased 65.82 10.66 3335 1244880 193882 89186350
Hepatic failure 65.71 10.66 302 1247913 39426 89340806
Nasal oedema 65.67 10.66 220 1247995 6364 89373868
Cataract 65.62 10.66 1375 1246840 70717 89309515
Renal impairment 65.32 10.66 1039 1247176 104382 89275850
Extrapyramidal disorder 65.14 10.66 77 1248138 16226 89364006
Unintended pregnancy 65.01 10.66 13 1248202 7624 89372608
Salivary hypersecretion 64.97 10.66 22 1248193 9070 89371162
Device adhesion issue 64.61 10.66 8 1248207 6683 89373549
Abnormal behaviour 64.56 10.66 134 1248081 22494 89357738
Obliterative bronchiolitis 64.36 10.66 125 1248090 2556 89377676
Product prescribing error 64.13 10.66 207 1248008 29938 89350294
Infection reactivation 64.06 10.66 104 1248111 1836 89378396
Cytomegalovirus gastrointestinal infection 63.84 10.66 50 1248165 368 89379864
Blastomycosis 63.70 10.66 52 1248163 409 89379823
Breast cancer 63.43 10.66 456 1247759 53305 89326927
Anaphylactic shock 63.24 10.66 223 1247992 31394 89348838
Coccidioidomycosis 63.06 10.66 80 1248135 1113 89379119
Osteoporotic fracture 62.94 10.66 175 1248040 4561 89375671
Listeriosis 62.46 10.66 97 1248118 1646 89378586
Panniculitis 62.14 10.66 376 1247839 14082 89366150
Device use error 62.08 10.66 12 1248203 7209 89373023
Depressed mood 61.70 10.66 421 1247794 49801 89330431
Myalgia 61.66 10.66 1888 1246327 173237 89206995
Foetal death 61.45 10.66 120 1248095 20603 89359629
Food allergy 61.42 10.66 165 1248050 25313 89354919
Skin exfoliation 61.27 10.66 618 1247597 67295 89312937
Ketoacidosis 61.23 10.66 4 1248211 5591 89374641
Dust allergy 61.22 10.66 66 1248149 763 89379469
Chest X-ray abnormal 60.97 10.66 181 1248034 4901 89375331
Genital haemorrhage 60.56 10.66 22 1248193 8680 89371552
Metastases to lung 60.25 10.66 79 1248136 15912 89364320
Urinary incontinence 60.11 10.66 289 1247926 37277 89342955
Medication error 59.85 10.66 813 1247402 83839 89296393
Blood bilirubin increased 59.77 10.66 352 1247863 43118 89337114
Unintentional medical device removal 59.77 10.66 12 1248203 7018 89373214
Necrotising retinitis 59.72 10.66 54 1248161 495 89379737
Drug level decreased 59.61 10.66 279 1247936 9451 89370781
Drug reaction with eosinophilia and systemic symptoms 59.45 10.66 345 1247870 42413 89337819
Toxoplasmosis 59.36 10.66 96 1248119 1689 89378543
Muscle injury 58.68 10.66 2986 1245229 173668 89206564
Acute myocardial infarction 58.43 10.66 264 1247951 34626 89345606
Nightmare 58.39 10.66 133 1248082 21592 89358640
Upper gastrointestinal haemorrhage 58.30 10.66 145 1248070 22831 89357401
Subarachnoid haemorrhage 58.17 10.66 98 1248117 17806 89362426
Therapeutic response shortened 58.13 10.66 525 1247690 22354 89357878
Human herpesvirus 8 infection 58.06 10.66 46 1248169 345 89379887
Malacoplakia 57.94 10.66 43 1248172 289 89379943
Skin fissures 57.89 10.66 125 1248090 20684 89359548
Blood pressure decreased 57.87 10.66 706 1247509 74189 89306043
Ulcer 57.72 10.66 700 1247515 32182 89348050
Breast cancer female 57.69 10.66 72 1248143 14814 89365418
Alternaria infection 57.48 10.66 45 1248170 331 89379901
Blood urea increased 57.22 10.66 220 1247995 30193 89350039
Contrast media allergy 56.87 10.66 129 1248086 2952 89377280
Complication of device removal 56.82 10.66 9 1248206 6246 89373986
Polyarthritis 56.70 10.66 440 1247775 17910 89362322
Upper-airway cough syndrome 56.64 10.66 380 1247835 14755 89365477
Drug specific antibody 56.54 10.66 114 1248101 2398 89377834
Miosis 56.49 10.66 30 1248185 9454 89370778
Therapy interrupted 56.26 10.66 431 1247784 49677 89330555
Therapeutic response decreased 56.03 10.66 1626 1246589 88103 89292129
Acanthamoeba infection 55.69 10.66 25 1248190 50 89380182
Impaired work ability 55.67 10.66 456 1247759 18870 89361362
Mental status changes 55.65 10.66 373 1247842 44306 89335926
Focal segmental glomerulosclerosis 55.46 10.66 95 1248120 1756 89378476
Angioedema 55.42 10.66 598 1247617 64278 89315954
Liver function test abnormal 55.37 10.66 441 1247774 50404 89329828
Coronary artery disease 55.36 10.66 256 1247959 33367 89346865
Breast cancer stage I 55.08 10.66 32 1248183 9592 89370640
Hypogammaglobulinaemia 54.72 10.66 291 1247924 10383 89369849
Toxic epidermal necrolysis 54.55 10.66 246 1247969 32282 89347950
Duodenal ulcer perforation 54.46 10.66 3641 1244574 217647 89162585
Abnormal dreams 54.38 10.66 45 1248170 11212 89369020
Pseudomonas infection 54.30 10.66 371 1247844 14494 89365738
Ileostomy 54.28 10.66 97 1248118 1857 89378375
Candida infection 54.23 10.66 712 1247503 33345 89346887
American trypanosomiasis 54.17 10.66 37 1248178 214 89380018
Hypocalcaemia 54.14 10.66 351 1247864 42017 89338215
Respiratory disorder 54.13 10.66 1221 1246994 63595 89316637
Parvovirus B19 infection 54.03 10.66 68 1248147 938 89379294
Sexual dysfunction 53.89 10.66 3 1248212 4801 89375431
Diabetes mellitus 53.83 10.66 1221 1246994 63654 89316578
Lung transplant rejection 53.75 10.66 69 1248146 972 89379260
Sleep disorder due to general medical condition, insomnia type 53.70 10.66 2226 1245989 126468 89253764
Eosinophil count increased 53.58 10.66 336 1247879 12745 89367487
Tenosynovitis 53.47 10.66 364 1247851 14203 89366029
Myoclonus 53.44 10.66 115 1248100 19053 89361179
Heart transplant rejection 53.42 10.66 62 1248153 782 89379450
Product preparation error 53.42 10.66 38 1248177 10223 89370009
Confusional state 53.39 10.66 4585 1243630 381620 88998612
Substance abuse 53.35 10.66 6 1248209 5400 89374832
Biopsy lung abnormal 53.34 10.66 31 1248184 128 89380104
Device breakage 53.31 10.66 69 1248146 13975 89366257
Lupus nephritis 53.20 10.66 167 1248048 4665 89375567
C-reactive protein abnormal 53.15 10.66 2204 1246011 125225 89255007
Asthenia 52.97 10.66 6489 1241726 527262 88852970
Human polyomavirus infection 52.94 10.66 46 1248169 398 89379834
Clonus 52.86 10.66 8 1248207 5742 89374490
Status epilepticus 52.82 10.66 113 1248102 18761 89361471
Psoriatic arthropathy 52.69 10.66 3737 1244478 224598 89155634
Hypophagia 52.66 10.66 285 1247930 35652 89344580
Schizoaffective disorder 52.63 10.66 5 1248210 5142 89375090
Product adhesion issue 52.57 10.66 5 1248210 5137 89375095
COVID-19 pneumonia 52.42 10.66 429 1247786 17748 89362484
Respiratory tract infection 52.22 10.66 1122 1247093 57956 89322276
Feeling abnormal 52.21 10.66 1831 1246384 165404 89214828
Herpes simplex hepatitis 52.06 10.66 52 1248163 546 89379686
New onset diabetes after transplantation 51.68 10.66 32 1248183 152 89380080
Tumour marker increased 51.32 10.66 9 1248206 5798 89374434
Uterine perforation 51.06 10.66 20 1248195 7534 89372698
Liver transplant rejection 50.88 10.66 88 1248127 1640 89378592
Epidural lipomatosis 50.79 10.66 36 1248179 223 89380009
Hot flush 50.54 10.66 549 1247666 58939 89321293
Clostridium difficile infection 50.52 10.66 740 1247475 35505 89344727
Electrocardiogram QRS complex prolonged 50.43 10.66 19 1248196 7329 89372903
Joint effusion 49.93 10.66 452 1247763 19258 89360974
Euglycaemic diabetic ketoacidosis 49.86 10.66 12 1248203 6189 89374043
Osteonecrosis 49.77 10.66 567 1247648 25674 89354558
Animal scratch 49.76 10.66 90 1248125 1740 89378492
Blood creatinine increased 49.69 10.66 1041 1247174 100345 89279887
Secondary immunodeficiency 49.67 10.66 98 1248117 2028 89378204
Body height below normal 49.52 10.66 99 1248116 2069 89378163
Colectomy 49.35 10.66 129 1248086 3238 89376994
Herpes simplex 49.11 10.66 273 1247942 9908 89370324
Muscle twitching 48.87 10.66 170 1248045 24032 89356200
Pruritus allergic 48.85 10.66 87 1248128 1661 89378571
Injection site pain 48.82 10.66 1926 1246289 171773 89208459
Granuloma 48.41 10.66 191 1248024 5994 89374238
Herpes simplex oesophagitis 48.37 10.66 32 1248183 174 89380058
Lip swelling 48.25 10.66 322 1247893 38288 89341944
Immunosuppression 48.10 10.66 308 1247907 11769 89368463
Osteonecrosis of jaw 47.93 10.66 328 1247887 38775 89341457
Rash maculo-papular 47.90 10.66 348 1247867 40585 89339647
Eosinophilic granulomatosis with polyangiitis 47.89 10.66 107 1248108 2423 89377809
Cytomegalovirus chorioretinitis 47.71 10.66 104 1248111 2315 89377917
Sinus tachycardia 47.60 10.66 216 1247999 28297 89351935
Human antichimeric antibody positive 47.50 10.66 87 1248128 1699 89378533
Irritable bowel syndrome 47.49 10.66 3393 1244822 204055 89176177
Loss of therapeutic response 47.43 10.66 86 1248129 1666 89378566
Crohn's disease 47.42 10.66 161 1248054 4690 89375542
Helicobacter infection 47.33 10.66 3683 1244532 223167 89157065
JC virus infection 47.06 10.66 111 1248104 2608 89377624
Folliculitis 46.71 10.66 3342 1244873 201011 89179221
Mucormycosis 46.71 10.66 137 1248078 3684 89376548
Granuloma skin 46.70 10.66 279 1247936 10401 89369831
Aphthous ulcer 46.67 10.66 402 1247813 16885 89363347
Therapy cessation 46.58 10.66 301 1247914 36060 89344172
Galactorrhoea 46.57 10.66 5 1248210 4667 89375565
Acquired haemophilia 46.25 10.66 65 1248150 1004 89379228
Mycobacterium chelonae infection 46.24 10.66 51 1248164 606 89379626
Ejection fraction decreased 46.18 10.66 195 1248020 26058 89354174
Blood parathyroid hormone decreased 45.89 10.66 307 1247908 11909 89368323
Ovarian hyperstimulation syndrome 45.86 10.66 12 1248203 5850 89374382
Atrial tachycardia 45.48 10.66 13 1248202 5977 89374255
Cyanosis 45.40 10.66 128 1248087 19327 89360905
Cat scratch disease 45.39 10.66 35 1248180 251 89379981
Device malfunction 45.35 10.66 143 1248072 20834 89359398
Haemoglobin decreased 45.25 10.66 1797 1246418 160159 89220073
Cholestasis 45.23 10.66 303 1247912 35996 89344236
Disseminated aspergillosis 44.94 10.66 44 1248171 450 89379782
Hyperprolactinaemia 44.70 10.66 10 1248205 5423 89374809
Perinephric abscess 44.62 10.66 36 1248179 278 89379954
Femoral neck fracture 44.57 10.66 45 1248170 10188 89370044
Myopathy 44.50 10.66 329 1247886 13189 89367043
Dysphagia 44.44 10.66 1191 1247024 111087 89269145
Mental impairment 44.42 10.66 103 1248112 16617 89363615
Diabetic ketoacidosis 44.36 10.66 179 1248036 24228 89356004
Intestinal anastomosis 44.33 10.66 59 1248156 863 89379369
Bloody discharge 44.30 10.66 97 1248118 2166 89378066
Delirium 44.23 10.66 1096 1247119 103263 89276969
Carotid artery occlusion 44.19 10.66 16 1248199 6326 89373906
Faecaloma 44.15 10.66 47 1248168 10384 89369848
Calciphylaxis 44.13 10.66 124 1248091 3252 89376980
Pre-existing disease 44.12 10.66 30 1248185 172 89380060
Heart rate decreased 44.08 10.66 1006 1247209 52499 89327733
Application site erythema 44.05 10.66 9 1248206 5199 89375033
Blood sodium decreased 43.85 10.66 213 1248002 27400 89352832
Disseminated cytomegaloviral infection 43.81 10.66 35 1248180 266 89379966
Apnoea 43.81 10.66 39 1248176 9375 89370857
Vasogenic cerebral oedema 43.75 10.66 70 1248145 1220 89379012
Disseminated blastomycosis 43.71 10.66 22 1248193 63 89380169
Microsporidia infection 43.60 10.66 37 1248178 309 89379923
Hypotonia 43.51 10.66 56 1248159 11370 89368862
Drug dose omission by device 43.42 10.66 46 1248169 10185 89370047
Hypertonia 43.41 10.66 9 1248206 5146 89375086
Sensory disturbance 43.36 10.66 92 1248123 15321 89364911
Vertigo 43.25 10.66 688 1247527 69123 89311109
Nasal congestion 43.24 10.66 1478 1246737 81936 89298296
Bronchial disorder 43.13 10.66 77 1248138 1473 89378759
Arthritis bacterial 43.09 10.66 210 1248005 7235 89372997
Scedosporium infection 43.05 10.66 55 1248160 771 89379461
Systemic lupus erythematosus rash 42.96 10.66 99 1248116 2290 89377942
Hypoxia 42.71 10.66 720 1247495 71679 89308553
Pleural effusion 42.50 10.66 1195 1247020 110796 89269436
Personality change 42.38 10.66 24 1248191 7297 89372935
Sickle cell anaemia with crisis 42.13 10.66 24 1248191 7273 89372959
Vascular device infection 42.08 10.66 62 1248153 11890 89368342
Lymphocyte count decreased 41.98 10.66 296 1247919 34754 89345478
Product administration interrupted 41.87 10.66 67 1248148 12425 89367807
Visceral leishmaniasis 41.62 10.66 48 1248167 601 89379631
Sleep terror 41.52 10.66 6 1248209 4458 89375774
COVID-19 41.51 10.66 2778 1245437 166065 89214167
Gastritis 41.48 10.66 371 1247844 41382 89338850
Pseudohyponatraemia 41.39 10.66 19 1248196 41 89380191
Ear pain 41.22 10.66 1064 1247151 56638 89323594
Treatment noncompliance 40.95 10.66 485 1247730 51242 89328990
Scleritis 40.90 10.66 161 1248054 5047 89375185
Mobility decreased 40.83 10.66 3997 1244218 246737 89133495
Musculoskeletal disorder 40.67 10.66 469 1247746 21300 89358932
Urinary tract candidiasis 40.66 10.66 51 1248164 701 89379531
Antipsychotic drug level increased 40.49 10.66 3 1248212 3776 89376456
Pregnancy with contraceptive device 40.35 10.66 10 1248205 5056 89375176
Schizophrenia 40.33 10.66 91 1248124 14823 89365409
Polyp 40.29 10.66 210 1248005 7434 89372798
Vital capacity decreased 40.28 10.66 82 1248133 1737 89378495
Pregnancy with implant contraceptive 40.25 10.66 3 1248212 3758 89376474
Speech disorder 40.22 10.66 417 1247798 45168 89335064
Visual impairment 40.22 10.66 1454 1246761 130911 89249321
Device occlusion 40.22 10.66 41 1248174 9241 89370991
Incorrect product administration duration 40.19 10.66 134 1248081 19188 89361044
Tension headache 40.16 10.66 27 1248188 7482 89372750
Drug specific antibody present 39.76 10.66 166 1248049 5348 89374884
Back pain 39.67 10.66 3794 1244421 313381 89066851
Coma scale abnormal 39.53 10.66 14 1248201 5612 89374620
Oropharyngeal pain 39.47 10.66 1953 1246262 113234 89266998
Device leakage 39.06 10.66 48 1248167 9943 89370289
Bone pain 39.02 10.66 609 1247606 61374 89318858
Toxic skin eruption 38.90 10.66 101 1248114 15673 89364559
Mucocutaneous leishmaniasis 38.90 10.66 37 1248178 364 89379868
Granulomatosis with polyangiitis 38.88 10.66 100 1248115 2485 89377747
Influenza 38.75 10.66 2316 1245899 136948 89243284
Serum sickness 38.61 10.66 122 1248093 3420 89376812
Intermenstrual bleeding 38.55 10.66 42 1248173 9181 89371051
Dermatomyositis 38.52 10.66 118 1248097 3252 89376980
Knee arthroplasty 38.48 10.66 1455 1246760 81727 89298505
Human ehrlichiosis 38.46 10.66 28 1248187 182 89380050
Epstein-Barr virus associated lymphoma 38.26 10.66 48 1248167 660 89379572
Cytopenia 38.19 10.66 388 1247827 17061 89363171
Laboratory test abnormal 38.11 10.66 380 1247835 41474 89338758
Sporotrichosis 38.00 10.66 18 1248197 43 89380189
Erythema multiforme 38.00 10.66 69 1248146 12177 89368055
Interstitial lung disease 37.91 10.66 1347 1246868 75058 89305174
Caesarean section 37.84 10.66 130 1248085 18447 89361785
Diplopia 37.65 10.66 236 1247979 28478 89351754
Ataxia 37.61 10.66 125 1248090 17917 89362315
Irritability 37.60 10.66 312 1247903 35350 89344882
Sputum purulent 37.41 10.66 67 1248148 1285 89378947
Urinary tract discomfort 37.32 10.66 54 1248161 858 89379374
Wrist surgery 37.28 10.66 55 1248160 890 89379342
Glomerulonephritis membranoproliferative 37.16 10.66 34 1248181 317 89379915
Blister 37.10 10.66 4034 1244181 250964 89129268
Ventricular septal defect 37.07 10.66 14 1248201 5393 89374839
Multiple sclerosis 36.93 10.66 228 1247987 27612 89352620
Fear 36.87 10.66 112 1248103 16510 89363722
Hypernatraemia 36.80 10.66 45 1248170 9342 89370890
Tuberculin test positive 36.74 10.66 124 1248091 3601 89376631
Right ventricular failure 36.73 10.66 138 1248077 19067 89361165
Secretion discharge 36.50 10.66 357 1247858 15539 89364693
Cardiogenic shock 36.43 10.66 193 1248022 24275 89355957
Long QT syndrome 36.24 10.66 6 1248209 4031 89376201
Maternal exposure during delivery 36.17 10.66 5 1248210 3841 89376391
Aphasia 36.01 10.66 396 1247819 42416 89337816
Mycotic allergy 35.96 10.66 58 1248157 1018 89379214
Ejection fraction 35.89 10.66 107 1248108 2904 89377328
Pneumonia cytomegaloviral 35.62 10.66 109 1248106 3002 89377230
Bradypnoea 35.57 10.66 10 1248205 4648 89375584
Cholecystitis chronic 35.55 10.66 50 1248165 9776 89370456
Total lung capacity increased 35.30 10.66 150 1248065 4871 89375361
Psychomotor retardation 35.26 10.66 11 1248204 4778 89375454
Kidney fibrosis 35.24 10.66 88 1248127 2146 89378086
Somnambulism 35.23 10.66 21 1248194 6207 89374025
Acute generalised exanthematous pustulosis 35.14 10.66 86 1248129 13617 89366615
Erythema 35.10 10.66 2699 1245516 226547 89153685
Chorioretinitis 35.08 10.66 50 1248165 783 89379449
Cholelithiasis 35.08 10.66 510 1247705 51996 89328236
Pyoderma gangrenosum 35.06 10.66 138 1248077 4326 89375906
Atrial septal defect 34.97 10.66 37 1248178 8197 89372035
Pulmonary embolism 34.94 10.66 1459 1246756 129361 89250871
Arthrodesis 34.93 10.66 106 1248109 2906 89377326
Device deployment issue 34.87 10.66 12 1248203 4897 89375335
Graft loss 34.70 10.66 37 1248178 422 89379810
Therapy responder 34.67 10.66 32 1248183 302 89379930
Renal function test abnormal 34.42 10.66 29 1248186 7162 89373070
Metastases to lymph nodes 34.39 10.66 68 1248147 11621 89368611
Pneumonia aspiration 34.31 10.66 379 1247836 40561 89339671
Rhinorrhoea 34.24 10.66 1516 1246699 86800 89293432
Bone swelling 34.21 10.66 75 1248140 1676 89378556
Creatinine renal clearance increased 34.05 10.66 3 1248212 3278 89376954
Donor specific antibody present 34.02 10.66 27 1248188 203 89380029
Respiratory acidosis 33.90 10.66 37 1248178 8082 89372150
Blood calcium increased 33.90 10.66 72 1248143 11986 89368246
Peak expiratory flow rate decreased 33.85 10.66 43 1248172 599 89379633
Nodule 33.78 10.66 536 1247679 26150 89354082
Bradyphrenia 33.70 10.66 33 1248182 7579 89372653
Necrotising herpetic retinopathy 33.63 10.66 22 1248193 117 89380115
Pulmonary hypertension 33.55 10.66 399 1247816 42124 89338108
Enterococcal infection 33.37 10.66 244 1247971 9747 89370485
Escherichia bacteraemia 33.36 10.66 162 1248053 5573 89374659
Stress cardiomyopathy 33.33 10.66 85 1248130 13270 89366962
Ureaplasma infection 33.32 10.66 51 1248164 854 89379378
Ventricular extrasystoles 33.32 10.66 84 1248131 13166 89367066
Hospitalisation 33.30 10.66 1433 1246782 126667 89253565
International normalised ratio fluctuation 33.23 10.66 106 1248109 2987 89377245
Lennox-Gastaut syndrome 33.18 10.66 30 1248185 275 89379957
Escherichia infection 33.16 10.66 350 1247865 15545 89364687
Body temperature decreased 33.10 10.66 486 1247729 23330 89356902
Respiratory symptom 33.03 10.66 131 1248084 4121 89376111
Thrombotic microangiopathy 33.00 10.66 347 1247868 15396 89364836
Bone density decreased 32.99 10.66 375 1247840 16970 89363262
Electrocardiogram abnormal 32.88 10.66 57 1248158 10241 89369991
Drug screen positive 32.82 10.66 6 1248209 3751 89376481
Infective scleritis 32.75 10.66 16 1248199 42 89380190
Aplastic anaemia 32.69 10.66 85 1248130 13184 89367048
Abscess 32.65 10.66 401 1247814 18490 89361742
SARS-CoV-2 RNA increased 32.64 10.66 21 1248194 108 89380124
Pruritus genital 32.62 10.66 11 1248204 4547 89375685
Bronchopleural fistula 32.52 10.66 28 1248187 239 89379993
Sudden death 32.50 10.66 63 1248152 10846 89369386
Pre-engraftment immune reaction 32.43 10.66 28 1248187 240 89379992
Chest pain 32.41 10.66 3880 1244335 315765 89064467
Polycystic ovaries 32.38 10.66 159 1248056 5495 89374737
Ileal stenosis 32.38 10.66 91 1248124 2387 89377845
B-cell lymphoma recurrent 32.34 10.66 38 1248177 486 89379746
Cytomegalovirus oesophagitis 32.28 10.66 34 1248181 382 89379850
Mood altered 32.26 10.66 124 1248091 17020 89363212
Heavy menstrual bleeding 32.23 10.66 159 1248056 20371 89359861
Mycoplasma infection 32.21 10.66 50 1248165 848 89379384
Alveolar osteitis 32.15 10.66 58 1248157 1119 89379113
Mouth ulceration 32.12 10.66 749 1247466 39225 89341007
Periostitis 32.12 10.66 36 1248179 436 89379796
Drug level increased 32.01 10.66 237 1247978 27525 89352707
Loose body in joint 32 10.66 64 1248151 1338 89378894
Acidosis 31.83 10.66 81 1248134 12655 89367577
Cutaneous leishmaniasis 31.67 10.66 20 1248195 99 89380133
Scleroderma renal crisis 31.66 10.66 35 1248180 417 89379815
Rheumatoid lung 31.55 10.66 126 1248089 3977 89376255
Fistula 31.53 10.66 279 1247936 11810 89368422
Hypertensive crisis 31.34 10.66 132 1248083 17652 89362580
Bronchial polyp 31.22 10.66 18 1248197 73 89380159
Multifocal micronodular pneumocyte hyperplasia 31.22 10.66 18 1248197 73 89380159
Neuroendocrine carcinoma of the skin 31.10 10.66 48 1248167 810 89379422
Enterobacter infection 30.99 10.66 92 1248123 2491 89377741
Giant cell arteritis 30.91 10.66 102 1248113 2927 89377305
Tuberculosis 30.89 10.66 286 1247929 12263 89367969
Disseminated strongyloidiasis 30.80 10.66 16 1248199 50 89380182
Electrolyte imbalance 30.70 10.66 196 1248019 23549 89356683
Cryptococcal fungaemia 30.57 10.66 19 1248196 91 89380141
Bradykinesia 30.55 10.66 29 1248186 6759 89373473
Immobile 30.49 10.66 171 1248044 6227 89374005
Episcleritis 30.44 10.66 57 1248158 1133 89379099
Taste disorder 30.43 10.66 631 1247584 60915 89319317
Lung hernia 30.41 10.66 10 1248205 3 89380229
Hypoglycaemic coma 30.32 10.66 3 1248212 2987 89377245
Glycosylated haemoglobin increased 30.30 10.66 111 1248104 15451 89364781
Nephrectomy 30.17 10.66 77 1248138 1904 89378328
Pleural mesothelioma malignant 30.13 10.66 16 1248199 53 89380179
Asphyxia 30.07 10.66 32 1248183 7071 89373161
Oesophageal ulcer 30.06 10.66 145 1248070 4974 89375258
Hip arthroplasty 29.95 10.66 1310 1246905 74898 89305334
Complications of transplanted lung 29.93 10.66 31 1248184 341 89379891
Product complaint 29.92 10.66 91 1248124 13409 89366823
Visual acuity reduced 29.88 10.66 194 1248021 23216 89357016
Abdominal pain upper 29.83 10.66 4070 1244145 328604 89051628
Atrioventricular block 29.81 10.66 47 1248168 8768 89371464
Ageusia 29.79 10.66 117 1248098 15959 89364273
Hepatocellular injury 29.79 10.66 255 1247960 28703 89351529
Amylase increased 29.78 10.66 32 1248183 7040 89373192
Sinus pain 29.76 10.66 150 1248065 5239 89374993
Tinnitus 29.73 10.66 416 1247799 42686 89337546
Perfume sensitivity 29.73 10.66 51 1248164 944 89379288
Abortion incomplete 29.73 10.66 4 1248211 3136 89377096
Feeling hot 29.69 10.66 832 1247383 77176 89303056
Prothrombin time prolonged 29.49 10.66 56 1248159 9716 89370516
Wheelchair user 29.46 10.66 196 1248019 7589 89372643
Lung diffusion test decreased 29.44 10.66 46 1248169 785 89379447
Mycobacterium abscessus infection 29.40 10.66 53 1248162 1022 89379210
Psychomotor hyperactivity 29.38 10.66 85 1248130 12728 89367504
Urine output decreased 29.35 10.66 83 1248132 12520 89367712
Erythema nodosum 29.31 10.66 156 1248059 5568 89374664
Renal tubular atrophy 29.17 10.66 49 1248166 891 89379341
Embedded device 29.12 10.66 11 1248204 4237 89375995
Petit mal epilepsy 29.07 10.66 16 1248199 4942 89375290
Headache 29.06 10.66 11065 1237150 851681 88528551
Babesiosis 28.99 10.66 27 1248188 258 89379974
Left ventricular dysfunction 28.98 10.66 104 1248111 14565 89365667
Urticaria 28.92 10.66 4815 1243400 307919 89072313
Oxygen saturation decreased 28.87 10.66 1782 1246433 105701 89274531
Presyncope 28.86 10.66 289 1247926 31516 89348716
Mental disorder 28.77 10.66 295 1247920 32023 89348209
Hepatitis B 28.73 10.66 131 1248084 4388 89375844
Chronic kidney disease 28.68 10.66 502 1247713 49689 89330543
Psychotic disorder 28.66 10.66 283 1247932 30947 89349285
Hypoaesthesia 28.66 10.66 3840 1244375 310370 89069862
Retching 28.59 10.66 151 1248064 19008 89361224
Faeces discoloured 28.59 10.66 174 1248041 21146 89359086
Pulmonary mass 28.58 10.66 556 1247659 28216 89352016
Contusion 28.53 10.66 3913 1244302 247303 89132929
Diffuse large B-cell lymphoma refractory 28.50 10.66 71 1248144 1729 89378503
Dry mouth 28.48 10.66 2165 1246050 181894 89198338
Head injury 28.47 10.66 283 1247932 30905 89349327
Transfusion 28.29 10.66 134 1248081 17354 89362878
Central nervous system vasculitis 28.21 10.66 53 1248162 1056 89379176
Temporal lobe epilepsy 28.21 10.66 32 1248183 393 89379839
Lower respiratory tract congestion 28.20 10.66 106 1248109 3250 89376982
Pneumocystis jirovecii infection 28.20 10.66 74 1248141 1862 89378370
Small for dates baby 28.16 10.66 17 1248198 4990 89375242
Pneumonia legionella 28.13 10.66 73 1248142 1824 89378408
Impaired gastric emptying 27.92 10.66 87 1248128 12722 89367510
Quality of life decreased 27.79 10.66 268 1247947 11621 89368611
Swollen tongue 27.77 10.66 455 1247760 45501 89334731
Oesophageal candidiasis 27.72 10.66 175 1248040 6654 89373578
Glomerulosclerosis 27.69 10.66 35 1248180 485 89379747
Human herpesvirus 6 infection 27.69 10.66 107 1248108 3325 89376907
Wound secretion 27.63 10.66 139 1248076 4851 89375381
Sinusitis fungal 27.52 10.66 74 1248141 1890 89378342
Application site pruritus 27.49 10.66 12 1248203 4235 89375997
Wrong patient received product 27.43 10.66 7 1248208 3470 89376762
Polyuria 27.36 10.66 61 1248154 9979 89370253
Pulmonary fibrosis 27.35 10.66 1774 1246441 105729 89274503
Cryptococcal meningoencephalitis 27.30 10.66 21 1248194 150 89380082
Disability assessment scale score increased 27.30 10.66 117 1248098 3814 89376418
Ileus 27.23 10.66 126 1248089 16420 89363812
Urinary tract infection 27.18 10.66 3741 1244474 301891 89078341
C-reactive protein increased 27.14 10.66 2875 1245340 178514 89201718
Human bocavirus infection 27.11 10.66 33 1248182 439 89379793
Systemic mycosis 27.07 10.66 63 1248152 1467 89378765
Angiocentric lymphoma 27.07 10.66 41 1248174 680 89379552
Paranasal sinus discomfort 27.01 10.66 162 1248053 6048 89374184
Proteinuria 26.96 10.66 461 1247754 22830 89357402
Metastatic squamous cell carcinoma 26.93 10.66 26 1248189 261 89379971
Progressive multifocal leukoencephalopathy 26.93 10.66 332 1247883 15323 89364909
Skin necrosis 26.90 10.66 354 1247861 16587 89363645
Product physical issue 26.88 10.66 23 1248192 5637 89374595
Multiple-drug resistance 26.73 10.66 41 1248174 7735 89372497
Ischaemic stroke 26.64 10.66 187 1248028 21979 89358253
Epstein-Barr virus test positive 26.51 10.66 40 1248175 661 89379571
Cerebral aspergillosis 26.43 10.66 36 1248179 539 89379693
Patent ductus arteriosus 26.42 10.66 15 1248200 4554 89375678
Atrioventricular block complete 26.42 10.66 60 1248155 9751 89370481
Cerebral haematoma 26.39 10.66 13 1248202 4276 89375956
Infective tenosynovitis 26.35 10.66 30 1248185 370 89379862
Panic attack 26.31 10.66 234 1247981 26131 89354101
Blood thyroid stimulating hormone increased 26.30 10.66 54 1248161 9101 89371131
Thirst 26.28 10.66 125 1248090 16170 89364062
Hepatic cyst 26.26 10.66 31 1248184 6537 89373695
Symptom masked 26.23 10.66 49 1248166 972 89379260
Steroid withdrawal syndrome 26.18 10.66 39 1248176 637 89379595
Legionella infection 26.17 10.66 34 1248181 485 89379747
Reversible airways obstruction 26.08 10.66 73 1248142 1910 89378322
Disseminated tuberculosis 25.92 10.66 102 1248113 3197 89377035
Philadelphia positive chronic myeloid leukaemia 25.88 10.66 13 1248202 37 89380195
Febrile neutropenia 25.87 10.66 1854 1246361 156495 89223737
Sputum culture positive 25.86 10.66 79 1248136 2174 89378058
Blood test abnormal 25.84 10.66 419 1247796 20533 89359699
Hepatosplenic T-cell lymphoma 25.83 10.66 39 1248176 645 89379587
Prescribed overdose 25.81 10.66 1090 1247125 96535 89283697
Adenovirus infection 25.77 10.66 129 1248086 4493 89375739
Obsessive-compulsive disorder 25.74 10.66 15 1248200 4489 89375743
Acarodermatitis 25.55 10.66 58 1248157 1328 89378904
Implant site pain 25.52 10.66 3 1248212 2609 89377623
Pulmonary toxicity 25.52 10.66 257 1247958 11274 89368958
Pneumonia cryptococcal 25.51 10.66 54 1248161 1177 89379055
Pancreatitis acute 25.47 10.66 301 1247914 31814 89348418
Blood potassium increased 25.45 10.66 174 1248041 20575 89359657
Anhedonia 25.37 10.66 77 1248138 11354 89368878
Substance-induced psychotic disorder 25.33 10.66 93 1248122 2819 89377413
Myocardial ischaemia 25.30 10.66 101 1248114 13713 89366519
Encephalitis viral 25.30 10.66 70 1248145 1819 89378413
Smoke sensitivity 25.29 10.66 33 1248182 473 89379759
Cryopyrin associated periodic syndrome 25.26 10.66 35 1248180 533 89379699
Ammonia increased 25.26 10.66 19 1248196 4967 89375265
Isosporiasis 25.24 10.66 12 1248203 29 89380203
Cutaneous malacoplakia 25.17 10.66 11 1248204 20 89380212
Shock 25.08 10.66 264 1247951 28514 89351718
Abortion spontaneous 25.04 10.66 560 1247655 53496 89326736
Cerebral toxoplasmosis 25.02 10.66 58 1248157 1347 89378885
Paronychia 24.94 10.66 45 1248170 7961 89372271
Arthritis infective 24.90 10.66 192 1248023 7800 89372432
Hypervolaemia 24.84 10.66 310 1247905 32447 89347785
Pulse absent 24.84 10.66 28 1248187 6027 89374205
Complement factor C3 decreased 24.83 10.66 26 1248189 290 89379942
Endocarditis bacterial 24.67 10.66 37 1248178 608 89379624
Thinking abnormal 24.65 10.66 81 1248134 11651 89368581
Systemic candida 24.61 10.66 134 1248081 4825 89375407
Extrasystoles 24.50 10.66 25 1248190 5632 89374600
Transplant failure 24.45 10.66 71 1248144 1898 89378334
Tractional retinal detachment 24.42 10.66 14 1248201 56 89380176
Eructation 24.37 10.66 73 1248142 10809 89369423
Disseminated mycobacterium avium complex infection 24.32 10.66 24 1248191 248 89379984
Pain in extremity 24.32 10.66 6761 1241454 443768 88936464
Product dispensing error 24.25 10.66 87 1248128 12186 89368046
Encephalopathy 24.21 10.66 472 1247743 45972 89334260
Penicillium infection 24.21 10.66 25 1248190 274 89379958
Flatulence 24.20 10.66 412 1247803 40955 89339277
Breast cancer recurrent 24.20 10.66 24 1248191 5479 89374753
Orf 24.19 10.66 11 1248204 23 89380209
Glomerulonephritis 24.16 10.66 82 1248133 2388 89377844
Pulmonary arterial hypertension 24.16 10.66 237 1247978 25950 89354282
Rhonchi 24.15 10.66 93 1248122 2885 89377347
Face oedema 24.13 10.66 205 1248010 23113 89357119
Incontinence 24.12 10.66 99 1248116 13336 89366896
Inappropriate schedule of product administration 24.08 10.66 2388 1245827 147545 89232687
Herpes simplex colitis 24.04 10.66 16 1248199 88 89380144
Pain in jaw 24.01 10.66 491 1247724 47494 89332738
Blood prolactin increased 23.98 10.66 10 1248205 3627 89376605
T-cell lymphoma 23.97 10.66 41 1248174 757 89379475
Hyperreflexia 23.96 10.66 34 1248181 6623 89373609
Sarcoma of skin 23.93 10.66 12 1248203 34 89380198
Bronchial secretion retention 23.89 10.66 106 1248109 3509 89376723
Emphysematous pyelonephritis 23.84 10.66 27 1248188 331 89379901
Herpes simplex reactivation 23.84 10.66 47 1248168 972 89379260
Campylobacter infection 23.78 10.66 52 1248163 1160 89379072
Product storage error 23.72 10.66 172 1248043 20069 89360163
Abortion induced 23.67 10.66 84 1248131 11804 89368428
Pancreatic carcinoma 23.57 10.66 50 1248165 8327 89371905
Heparin-induced thrombocytopenia 23.55 10.66 23 1248192 5289 89374943
Cutaneous calcification 23.44 10.66 21 1248194 190 89380042
Dyspepsia 23.41 10.66 2380 1245835 195780 89184452
Drug hypersensitivity 23.39 10.66 6938 1241277 456671 88923561
Latent tuberculosis 23.37 10.66 92 1248123 2884 89377348
Acute pulmonary histoplasmosis 23.36 10.66 18 1248197 129 89380103
Hypothyroidism 23.31 10.66 555 1247660 52572 89327660
Elbow deformity 23.29 10.66 59 1248156 1452 89378780
Pulmonary oedema 23.15 10.66 664 1247551 61416 89318816
Rash 23.12 10.66 11681 1236534 784419 88595813
Bursitis 23.07 10.66 1532 1246683 130122 89250110
Pyelonephritis fungal 23.02 10.66 21 1248194 195 89380037
Respiratory tract inflammation 22.91 10.66 35 1248180 585 89379647
Blood glucose decreased 22.91 10.66 209 1248006 23220 89357012
Chronic graft versus host disease in liver 22.88 10.66 26 1248189 320 89379912
Glomerulonephritis membranous 22.85 10.66 38 1248177 685 89379547
Pneumonia 22.79 10.66 9426 1238789 628633 88751599
Emphysema 22.76 10.66 262 1247953 11893 89368339
Coeliac disease 22.75 10.66 455 1247760 44155 89336077
Segmental diverticular colitis 22.74 10.66 19 1248196 155 89380077
Hepatic encephalopathy 22.59 10.66 105 1248110 13667 89366565
Immunosuppressant drug level decreased 22.56 10.66 50 1248165 1126 89379106
Pre-eclampsia 22.45 10.66 242 1247973 10806 89369426
Infected neoplasm 22.42 10.66 27 1248188 355 89379877
Genital herpes simplex 22.41 10.66 29 1248186 412 89379820
Needle issue 22.40 10.66 107 1248108 13827 89366405
Red blood cell count decreased 22.39 10.66 477 1247738 45874 89334358
Eye irritation 22.36 10.66 331 1247884 33647 89346585
On and off phenomenon 22.35 10.66 4 1248211 2539 89377693
Urate nephropathy 22.31 10.66 18 1248197 139 89380093
Disseminated sporotrichosis 22.28 10.66 10 1248205 20 89380212
Faecal volume decreased 22.21 10.66 23 1248192 253 89379979
Wrist deformity 22.20 10.66 96 1248119 3142 89377090
Drooling 22.17 10.66 18 1248197 4528 89375704
Fungal infection 22.13 10.66 756 1247459 41905 89338327
Joint laxity 22.08 10.66 83 1248132 2545 89377687
Injection site mass 22.06 10.66 196 1248019 21894 89358338
Multiple organ dysfunction syndrome 22.04 10.66 1152 1247063 67184 89313048
Rales 22.00 10.66 323 1247892 15504 89364728
Histoplasmosis cutaneous 21.96 10.66 10 1248205 21 89380211
Bedridden 21.93 10.66 260 1247955 11888 89368344
Kidney infection 21.88 10.66 489 1247726 25427 89354805
Infection parasitic 21.86 10.66 32 1248183 514 89379718
Squamous cell carcinoma 21.82 10.66 224 1247991 9877 89370355
Application site rash 21.79 10.66 5 1248210 2664 89377568
Glomerular filtration rate decreased 21.77 10.66 140 1248075 16792 89363440
Platelet count increased 21.72 10.66 406 1247809 20453 89359779
Carpal tunnel syndrome 21.65 10.66 456 1247759 23472 89356760
Large intestinal ulcer 21.61 10.66 109 1248106 3808 89376424
Multiple fractures 21.59 10.66 214 1248001 9348 89370884
Herpes zoster meningoencephalitis 21.57 10.66 28 1248187 399 89379833
Carbohydrate antigen 125 increased 21.50 10.66 9 1248206 3257 89376975
Skin plaque 21.45 10.66 221 1247994 9754 89370478
Haemolytic uraemic syndrome 21.35 10.66 86 1248129 2725 89377507
Exposure during pregnancy 21.33 10.66 2917 1245298 235493 89144739
Diabetic neuropathy 21.22 10.66 19 1248196 4555 89375677
Torus fracture 21.15 10.66 18 1248197 151 89380081
Bronchial neoplasm 21.13 10.66 31 1248184 499 89379733
Cholangitis sclerosing 21.09 10.66 73 1248142 2148 89378084
Myringotomy 21.08 10.66 10 1248205 24 89380208
Skin fragility 21.07 10.66 42 1248173 876 89379356
Eye movement disorder 21.00 10.66 33 1248182 6165 89374067
Maternal drugs affecting foetus 20.97 10.66 24 1248191 5131 89375101
Purulent pericarditis 20.96 10.66 13 1248202 62 89380170
Activated partial thromboplastin time prolonged 20.95 10.66 48 1248167 7777 89372455
Incorrect dose administered by device 20.95 10.66 29 1248186 5708 89374524
Underdose 20.84 10.66 575 1247640 53442 89326790
Diabetes mellitus inadequate control 20.83 10.66 161 1248054 18523 89361709
Cancer pain 20.83 10.66 15 1248200 4010 89376222
Injection site induration 20.82 10.66 74 1248141 10394 89369838
No adverse event 20.82 10.66 746 1247469 67236 89312996
Limb mass 20.77 10.66 100 1248115 3428 89376804
Colon injury 20.76 10.66 22 1248193 249 89379983
Amenorrhoea 20.66 10.66 87 1248128 11635 89368597
Middle insomnia 20.66 10.66 335 1247880 16416 89363816
Abdominal wall infection 20.62 10.66 16 1248199 116 89380116
Ear congestion 20.58 10.66 98 1248117 3344 89376888
Aspiration 20.56 10.66 129 1248086 15564 89364668
Viraemia 20.55 10.66 60 1248155 1609 89378623
B-cell lymphoma 20.50 10.66 102 1248113 3544 89376688
Herpes zoster cutaneous disseminated 20.47 10.66 20 1248195 204 89380028
Psychomotor skills impaired 20.43 10.66 7 1248208 2865 89377367
Soft tissue sarcoma 20.43 10.66 18 1248197 159 89380073
Kounis syndrome 20.41 10.66 5 1248210 2548 89377684
Skin lesion 20.36 10.66 666 1247549 36699 89343533
Unevaluable event 20.36 10.66 587 1247628 54261 89325971
Haematotoxicity 20.35 10.66 263 1247952 12272 89367960
Polydipsia 20.33 10.66 17 1248198 4214 89376018
Ileocaecal resection 20.17 10.66 31 1248184 521 89379711
Renal transplant 20.14 10.66 60 1248155 1628 89378604
Lung disorder 20.13 10.66 2359 1245856 147524 89232708
Respiratory rate increased 20.11 10.66 321 1247894 15680 89364552
Tachyarrhythmia 20.07 10.66 27 1248188 5379 89374853
Cutaneous coccidioidomycosis 20.05 10.66 9 1248206 18 89380214
Prosthesis user 20.04 10.66 13 1248202 68 89380164
Hypophosphataemia 20.04 10.66 121 1248094 14733 89365499
Metabolic alkalosis 20.03 10.66 12 1248203 3537 89376695
Papilloma viral infection 20.00 10.66 62 1248153 1720 89378512
Eosinophilic pneumonia chronic 19.95 10.66 20 1248195 211 89380021
Anticipatory anxiety 19.91 10.66 49 1248166 1184 89379048
Angina unstable 19.79 10.66 43 1248172 7100 89373132
Vasoplegia syndrome 19.78 10.66 7 1248208 2807 89377425
Low density lipoprotein increased 19.76 10.66 52 1248163 8033 89372199
Pyomyositis 19.74 10.66 27 1248188 406 89379826
Intestinal fibrosis 19.73 10.66 20 1248195 214 89380018
Rash papular 19.72 10.66 182 1248033 20173 89360059
Lyme disease 19.71 10.66 113 1248102 4149 89376083
Product residue present 19.70 10.66 18 1248197 4273 89375959
Lymphocele 19.70 10.66 38 1248177 773 89379459
Nystagmus 19.62 10.66 44 1248171 7183 89373049
Mucosal inflammation 19.60 10.66 624 1247591 57001 89323231
Metastases to peritoneum 19.59 10.66 17 1248198 4138 89376094
Mycoplasma test positive 19.59 10.66 16 1248199 126 89380106
Upper respiratory fungal infection 19.58 10.66 19 1248196 192 89380040
Fat embolism syndrome 19.57 10.66 11 1248204 42 89380190
Dermatitis acneiform 19.54 10.66 36 1248179 6318 89373914
Erythropoiesis abnormal 19.53 10.66 23 1248192 295 89379937
Joint warmth 19.49 10.66 61 1248154 1701 89378531
Frustration tolerance decreased 19.46 10.66 180 1248035 7716 89372516
Anger 19.45 10.66 110 1248105 13610 89366622
Oral herpes 19.44 10.66 602 1247613 32922 89347310
Apathy 19.42 10.66 82 1248133 10958 89369274
Injection site erythema 19.38 10.66 1134 1247081 97368 89282864
Blood pressure inadequately controlled 19.37 10.66 35 1248180 6189 89374043
Swollen joint count increased 19.31 10.66 1781 1246434 109425 89270807
Hypertrophic osteoarthropathy 19.31 10.66 10 1248205 31 89380201
Blood loss anaemia 19.30 10.66 73 1248142 10067 89370165
Hyperthermia 19.29 10.66 75 1248140 10260 89369972
Soft tissue injury 19.20 10.66 68 1248147 2024 89378208
Infusion site erythema 19.16 10.66 110 1248105 13560 89366672
Leiomyosarcoma metastatic 19.14 10.66 9 1248206 21 89380211
Tooth infection 19.11 10.66 387 1247828 19783 89360449
Skin graft rejection 19.08 10.66 10 1248205 32 89380200
Initial insomnia 19.07 10.66 65 1248150 9245 89370987
Hospice care 19.04 10.66 69 1248146 9635 89370597
Abscess limb 19.00 10.66 144 1248071 5818 89374414
Oral pain 18.96 10.66 326 1247889 32357 89347875
Paraesthesia oral 18.95 10.66 314 1247901 31345 89348887
Gastrointestinal procedural complication 18.94 10.66 28 1248187 454 89379778
Asthma-chronic obstructive pulmonary disease overlap syndrome 18.94 10.66 124 1248091 4775 89375457
Atrioventricular block second degree 18.91 10.66 20 1248195 4432 89375800
Endometrial ablation 18.90 10.66 43 1248172 986 89379246
Splenomegaly 18.86 10.66 266 1247949 12658 89367574
Dialysis 18.80 10.66 86 1248129 11243 89368989
Tachypnoea 18.77 10.66 195 1248020 21114 89359118
Complement factor C4 decreased 18.75 10.66 22 1248193 281 89379951
Complications of transplant surgery 18.70 10.66 18 1248197 180 89380052
Lung abscess 18.68 10.66 70 1248145 2143 89378089
Neurosarcoidosis 18.56 10.66 23 1248192 312 89379920
Bone disorder 18.51 10.66 433 1247782 22687 89357545
Bundle branch block right 18.51 10.66 29 1248186 5424 89374808
Glomerulonephritis rapidly progressive 18.48 10.66 49 1248166 1241 89378991
Fear of injection 18.47 10.66 189 1248026 8326 89371906
Enterocolitis 18.40 10.66 78 1248137 10412 89369820
Breast cancer stage IV 18.36 10.66 3 1248212 2035 89378197
Salmonellosis 18.36 10.66 49 1248166 1246 89378986
Adrenal suppression 18.35 10.66 42 1248173 967 89379265
Deep vein thrombosis 18.35 10.66 1053 1247162 90567 89289665
Oesophageal dilatation 18.35 10.66 29 1248186 500 89379732
Paracoccidioides infection 18.34 10.66 7 1248208 7 89380225
Meningitis coccidioides 18.33 10.66 9 1248206 24 89380208
Faecal calprotectin abnormal 18.32 10.66 18 1248197 185 89380047
Laryngeal stenosis 18.31 10.66 50 1248165 1289 89378943
Peptostreptococcus infection 18.31 10.66 14 1248201 99 89380133
Skin burning sensation 18.30 10.66 177 1248038 19434 89360798
Pulmonary cavitation 18.29 10.66 43 1248172 1008 89379224
Metabolic disorder 18.29 10.66 48 1248167 7422 89372810
Nose deformity 18.27 10.66 19 1248196 210 89380022
Oedematous kidney 18.27 10.66 16 1248199 140 89380092
Coagulopathy 18.19 10.66 219 1247996 23070 89357162
Forced vital capacity decreased 18.16 10.66 46 1248169 1132 89379100
Angina pectoris 18.05 10.66 406 1247809 38754 89341478
Perinephric collection 17.98 10.66 15 1248200 122 89380110
Clostridial sepsis 17.95 10.66 30 1248185 543 89379689
Nodular rash 17.95 10.66 18 1248197 190 89380042
Myasthenia gravis crisis 17.94 10.66 43 1248172 1021 89379211
Dermatitis bullous 17.91 10.66 77 1248138 10239 89369993
Rhegmatogenous retinal detachment 17.89 10.66 15 1248200 123 89380109
Bacterial infection 17.84 10.66 436 1247779 23008 89357224
Pneumonia necrotising 17.82 10.66 32 1248183 615 89379617
Cytomegalovirus mucocutaneous ulcer 17.81 10.66 11 1248204 52 89380180
Antibody test positive 17.79 10.66 85 1248130 2904 89377328
Joint stiffness 17.76 10.66 1276 1246939 76766 89303466
Eye abscess 17.75 10.66 16 1248199 146 89380086
Device use issue 17.74 10.66 15 1248200 3698 89376534
Sinus congestion 17.68 10.66 499 1247716 26925 89353307
Abdominal abscess 17.67 10.66 131 1248084 5256 89374976
Ecthyma 17.65 10.66 25 1248190 389 89379843
Toxic encephalopathy 17.64 10.66 61 1248154 8638 89371594
Joint destruction 17.63 10.66 269 1247946 13018 89367214
Bronchial haemorrhage 17.61 10.66 32 1248183 621 89379611
Mite allergy 17.59 10.66 37 1248178 803 89379429
Muscle spasticity 17.59 10.66 623 1247592 34699 89345533
Haemophilus infection 17.57 10.66 51 1248164 1363 89378869
Musculoskeletal pain 17.57 10.66 2652 1245563 168599 89211633
Autoinflammatory disease 17.56 10.66 21 1248194 274 89379958
Chromaturia 17.55 10.66 174 1248041 19013 89361219
Anaesthetic complication 17.55 10.66 6 1248209 2459 89377773
Pulmonary function test decreased 17.52 10.66 114 1248101 4380 89375852
Bronchopulmonary aspergillosis allergic 17.52 10.66 100 1248115 3666 89376566
Renal injury 17.45 10.66 77 1248138 10166 89370066
Chronic disease 17.45 10.66 18 1248197 197 89380035
Folate deficiency 17.45 10.66 11 1248204 3154 89377078
Ankle deformity 17.35 10.66 27 1248188 459 89379773
Breast pain 17.34 10.66 79 1248136 10339 89369893
Lymph node calcification 17.30 10.66 24 1248191 366 89379866
Oesophageal stenosis 17.28 10.66 101 1248114 3735 89376497
Nicotine dependence 17.24 10.66 42 1248173 1008 89379224
Human chorionic gonadotropin increased 17.23 10.66 3 1248212 1943 89378289
Angioimmunoblastic T-cell lymphoma 17.21 10.66 19 1248196 226 89380006
Haemorrhage subcutaneous 17.13 10.66 13 1248202 3383 89376849
Abscess intestinal 17.13 10.66 62 1248153 1866 89378366
Tunnel vision 17.11 10.66 57 1248158 1644 89378588
Herpes virus infection 16.99 10.66 148 1248067 6236 89373996
Premature labour 16.99 10.66 111 1248104 13265 89366967
Mean cell haemoglobin concentration abnormal 16.98 10.66 15 1248200 133 89380099
Adenomatous polyposis coli 16.98 10.66 15 1248200 133 89380099
Colitis ischaemic 16.96 10.66 100 1248115 12246 89367986
Coronary artery stenosis 16.95 10.66 29 1248186 5237 89374995
Diabetic retinopathy 16.92 10.66 8 1248207 2694 89377538
Hyperkinesia 16.90 10.66 3 1248212 1916 89378316
Pneumonia pseudomonal 16.88 10.66 88 1248127 3115 89377117
Intestinal ischaemia 16.88 10.66 64 1248151 8819 89371413
Disseminated varicella zoster virus infection 16.88 10.66 26 1248189 438 89379794
Abdominal pain lower 16.87 10.66 303 1247912 29874 89350358
Pseudomembranous colitis 16.86 10.66 17 1248198 3851 89376381
Pedal pulse abnormal 16.83 10.66 18 1248197 206 89380026
Pre-existing condition improved 16.82 10.66 67 1248148 9102 89371130
Bowel movement irregularity 16.82 10.66 150 1248065 6364 89373868
Disseminated coccidioidomycosis 16.80 10.66 15 1248200 135 89380097
Respiratory failure 16.74 10.66 1870 1246345 116548 89263684
Autoimmune thyroiditis 16.73 10.66 35 1248180 5858 89374374
Inadequate analgesia 16.70 10.66 12 1248203 3212 89377020
Menstruation irregular 16.69 10.66 56 1248159 8004 89372228
Type 2 diabetes mellitus 16.68 10.66 3110 1245105 200134 89180098
Organising pneumonia 16.66 10.66 169 1248046 7428 89372804
Catheter site erythema 16.64 10.66 26 1248189 4868 89375364
Porokeratosis 16.63 10.66 15 1248200 137 89380095
Cardiovascular disorder 16.62 10.66 113 1248102 13379 89366853
Hypersomnia 16.61 10.66 203 1248012 21328 89358904
Asthmatic crisis 16.61 10.66 61 1248154 1849 89378383
Inflammatory bowel disease 16.54 10.66 125 1248090 5046 89375186
Eczema 16.45 10.66 579 1247636 52291 89327941
Neutrophilic dermatosis 16.44 10.66 20 1248195 266 89379966
Synovial cyst 16.40 10.66 240 1247975 11512 89368720
Immune recovery uveitis 16.39 10.66 10 1248205 46 89380186
Accidental death 16.39 10.66 4 1248211 2044 89378188
Mycobacterium fortuitum infection 16.36 10.66 12 1248203 79 89380153
Exposure to SARS-CoV-2 16.28 10.66 72 1248143 2380 89377852
Pleomorphism 16.27 10.66 7 1248208 12 89380220
Pulmonary aplasia 16.27 10.66 7 1248208 12 89380220
Skin toxicity 16.26 10.66 44 1248171 6735 89373497
Occupational asthma 16.24 10.66 16 1248199 165 89380067
Aeromonas infection 16.24 10.66 16 1248199 165 89380067
Acanthoma 16.23 10.66 6 1248209 5 89380227
Peliosis hepatis 16.21 10.66 14 1248201 120 89380112
Juvenile idiopathic arthritis 16.19 10.66 102 1248113 3875 89376357
Cardiac failure acute 16.18 10.66 97 1248118 11832 89368400
Renal cyst 16.18 10.66 108 1248107 12842 89367390
Metastasis 16.15 10.66 38 1248177 6099 89374133
Bone density abnormal 16.13 10.66 105 1248110 4035 89376197
Viral mutation identified 16.12 10.66 4 1248211 2021 89378211
Application site pain 16.12 10.66 25 1248190 4695 89375537
Urine protein/creatinine ratio increased 16.11 10.66 40 1248175 972 89379260
Diffuse alveolar damage 16.10 10.66 42 1248173 1053 89379179
Enuresis 16.06 10.66 14 1248201 3400 89376832
Hypochloraemia 16.06 10.66 8 1248207 2614 89377618
Upper respiratory tract infection bacterial 15.97 10.66 15 1248200 145 89380087
Cerebral venous sinus thrombosis 15.95 10.66 70 1248145 2306 89377926
Injection site nodule 15.95 10.66 23 1248192 4450 89375782
Meningoradiculitis 15.95 10.66 14 1248201 123 89380109
Blood chloride decreased 15.94 10.66 40 1248175 6279 89373953
Meningitis pneumococcal 15.94 10.66 26 1248189 461 89379771
Cardiac valve abscess 15.90 10.66 12 1248203 83 89380149
Hypoalbuminaemia 15.90 10.66 141 1248074 15756 89364476
Pelvic pain 15.90 10.66 135 1248080 15222 89365010
Cardiomyopathy acute 15.89 10.66 20 1248195 276 89379956
Neovascularisation 15.85 10.66 54 1248161 1576 89378656
Kaposi's sarcoma 15.74 10.66 15 1248200 148 89380084
Lacunar infarction 15.70 10.66 14 1248201 3363 89376869
Eosinophil count abnormal 15.70 10.66 36 1248179 830 89379402
Ophthalmic herpes zoster 15.68 10.66 78 1248137 2710 89377522
Periorbital oedema 15.67 10.66 45 1248170 6754 89373478
Blood bicarbonate decreased 15.65 10.66 12 1248203 3107 89377125
Cross sensitivity reaction 15.65 10.66 10 1248205 2847 89377385
Pruritus 15.64 10.66 6982 1241233 534543 88845689
Cardiac failure chronic 15.64 10.66 34 1248181 5612 89374620
General physical health deterioration 15.62 10.66 4506 1243709 350609 89029623
Bronchial obstruction 15.59 10.66 55 1248160 1634 89378598
Drug tolerance decreased 15.58 10.66 565 1247650 31565 89348667
Rheumatic fever 15.56 10.66 2370 1245845 150751 89229481
Pericardial effusion 15.55 10.66 387 1247828 36446 89343786
Blood thyroid stimulating hormone decreased 15.54 10.66 35 1248180 5705 89374527
Colectomy total 15.52 10.66 16 1248199 175 89380057
Urticaria thermal 15.51 10.66 27 1248188 506 89379726
Dysphoria 15.49 10.66 39 1248176 6115 89374117
Rhinitis 15.48 10.66 268 1247947 13304 89366928
Sinus node dysfunction 15.48 10.66 32 1248183 5380 89374852
Nail bed inflammation 15.47 10.66 3 1248212 1798 89378434
Parvovirus infection 15.47 10.66 26 1248189 473 89379759
Tendon rupture 15.46 10.66 195 1248020 9048 89371184
Cervix disorder 15.44 10.66 31 1248184 650 89379582
Chest discomfort 15.42 10.66 2153 1246062 136212 89244020
Lupus vasculitis 15.40 10.66 29 1248186 579 89379653
Wrong product administered 15.37 10.66 54 1248161 7611 89372621
Drug-induced liver injury 15.32 10.66 1054 1247161 89264 89290968
Granulocytopenia 15.31 10.66 42 1248173 6399 89373833
Agranulocytosis 15.26 10.66 366 1247849 34636 89345596
Gastroenteritis norovirus 15.20 10.66 69 1248146 2307 89377925
Basal cell carcinoma 15.19 10.66 583 1247632 32806 89347426
Nerve injury 15.18 10.66 226 1247989 10880 89369352
Wound complication 15.16 10.66 115 1248100 4648 89375584
Therapy change 15.15 10.66 61 1248154 8261 89371971
Somatic symptom disorder 15.14 10.66 15 1248200 3426 89376806
Salpingo-oophorectomy unilateral 15.13 10.66 38 1248177 930 89379302
Pancreas transplant rejection 15.13 10.66 15 1248200 156 89380076
Catheter site pain 15.12 10.66 34 1248181 5545 89374687
Dysaesthesia 15.09 10.66 31 1248184 5224 89375008
Neck deformity 15.09 10.66 65 1248150 2124 89378108
Tumour haemorrhage 15.08 10.66 5 1248210 2089 89378143
Hallucinations, mixed 15.07 10.66 37 1248178 5852 89374380
Immunoglobulins decreased 15.05 10.66 53 1248162 1573 89378659
Major depression 15.03 10.66 79 1248136 9956 89370276
Bladder pain 14.99 10.66 76 1248139 2661 89377571
Anovulatory cycle 14.98 10.66 15 1248200 158 89380074
Paranoia 14.98 10.66 110 1248105 12798 89367434
Genitourinary tract infection 14.93 10.66 18 1248197 237 89379995
Foot deformity 14.92 10.66 983 1247232 58668 89321564
Language disorder 14.92 10.66 9 1248206 2643 89377589
Arteriosclerosis 14.86 10.66 88 1248127 10765 89369467
Encephalitis brain stem 14.86 10.66 14 1248201 136 89380096
Colon cancer 14.84 10.66 89 1248126 10855 89369377
Hepatotoxicity 14.82 10.66 773 1247442 45069 89335163
Meningitis histoplasma 14.82 10.66 6 1248209 8 89380224
Cutaneous nocardiosis 14.81 10.66 11 1248204 74 89380158
Microangiopathic haemolytic anaemia 14.79 10.66 34 1248181 785 89379447
Tic 14.78 10.66 4 1248211 1907 89378325
Cerebellar syndrome 14.72 10.66 19 1248196 3853 89376379
CD8 lymphocytes increased 14.70 10.66 7 1248208 17 89380215
Angiosarcoma metastatic 14.70 10.66 11 1248204 75 89380157
Haemorrhage 14.67 10.66 793 1247422 68576 89311656
Stoma closure 14.64 10.66 16 1248199 188 89380044
Ovarian cyst 14.64 10.66 160 1248055 17158 89363074
Mycobacterium tuberculosis complex test positive 14.63 10.66 73 1248142 2539 89377693
Acute coronary syndrome 14.63 10.66 88 1248127 10725 89369507
Rectal prolapse 14.62 10.66 66 1248149 2201 89378031
Selective eating disorder 14.61 10.66 5 1248210 2048 89378184
Exposure via skin contact 14.55 10.66 87 1248128 10618 89369614
Dysuria 14.54 10.66 422 1247793 38979 89341253
Brain oedema 14.54 10.66 161 1248054 17224 89363008
Rhodococcus infection 14.54 10.66 14 1248201 140 89380092
Glomerulonephritis proliferative 14.54 10.66 18 1248197 244 89379988
Hyperaesthesia 14.53 10.66 87 1248128 10615 89369617
Renal tubular injury 14.53 10.66 44 1248171 1205 89379027
Metastases to pleura 14.51 10.66 5 1248210 2039 89378193
Eyelid oedema 14.51 10.66 96 1248119 11438 89368794
Pericarditis fungal 14.49 10.66 10 1248205 59 89380173
Emphysematous cystitis 14.32 10.66 20 1248195 307 89379925
Chronic graft versus host disease oral 14.32 10.66 17 1248198 220 89380012
Immune system disorder 14.28 10.66 237 1247978 11668 89368564
Opportunistic infection 14.26 10.66 64 1248151 2129 89378103
Oligohydramnios 14.26 10.66 51 1248164 7150 89373082
Ophthalmic herpes simplex 14.26 10.66 29 1248186 614 89379618
Tetany 14.22 10.66 9 1248206 2575 89377657
Hyperbilirubinaemia 14.21 10.66 123 1248092 13813 89366419
Injection site swelling 14.20 10.66 676 1247539 59163 89321069
Atypical mycobacterial infection 14.20 10.66 52 1248163 1574 89378658
Psychogenic seizure 14.19 10.66 5 1248210 2011 89378221
Pneumonia serratia 14.17 10.66 7 1248208 19 89380213
Neoplasm recurrence 14.16 10.66 85 1248130 3174 89377058
Infusion site pain 14.15 10.66 189 1248026 19549 89360683
Squamous cell carcinoma of skin 14.15 10.66 161 1248054 7288 89372944
Nephrotic syndrome 14.11 10.66 159 1248056 7180 89373052
Oropharyngitis fungal 14.10 10.66 10 1248205 62 89380170
Intestinal ulcer 14.08 10.66 53 1248162 1626 89378606
Superior sagittal sinus thrombosis 14.05 10.66 33 1248182 773 89379459
Right ventricular diastolic collapse 14.05 10.66 6 1248209 10 89380222
Acute respiratory distress syndrome 14.05 10.66 505 1247710 28181 89352051
Cold sweat 14.04 10.66 125 1248090 13956 89366276
Mycobacterium haemophilum infection 14.01 10.66 16 1248199 198 89380034
Hepatitis acute 14.01 10.66 90 1248125 10797 89369435
Anal abscess 14.00 10.66 130 1248085 5578 89374654
Injury associated with device 13.99 10.66 25 1248190 4439 89375793
Segmented hyalinising vasculitis 13.98 10.66 10 1248205 63 89380169
Nephrolithiasis 13.97 10.66 818 1247397 48267 89331965
Aortic valve stenosis 13.97 10.66 23 1248192 4217 89376015
Drug abuser 13.95 10.66 10 1248205 2680 89377552
Q fever 13.94 10.66 14 1248201 148 89380084
Anosmia 13.94 10.66 79 1248136 9769 89370463
Porocarcinoma 13.92 10.66 7 1248208 20 89380212
Poor quality product administered 13.91 10.66 21 1248194 3987 89376245
Tearfulness 13.90 10.66 28 1248187 4752 89375480
Papilloedema 13.89 10.66 110 1248105 4505 89375727
Meningoencephalitis herpetic 13.89 10.66 48 1248167 1411 89378821
Urine ketone body present 13.89 10.66 9 1248206 2543 89377689
Complications of bone marrow transplant 13.89 10.66 24 1248191 447 89379785
Systemic infection 13.86 10.66 28 1248187 4747 89375485
Subdural haemorrhage 13.86 10.66 16 1248199 3407 89376825
Tongue biting 13.85 10.66 6 1248209 2127 89378105
Toothache 13.79 10.66 219 1247996 22011 89358221
Broncholithiasis 13.78 10.66 19 1248196 288 89379944
Infusion site reaction 13.76 10.66 182 1248033 18857 89361375
Device related infection 13.76 10.66 261 1247954 25525 89354707
Glaucoma 13.76 10.66 379 1247836 20376 89359856
Primary immunodeficiency syndrome 13.74 10.66 9 1248206 48 89380184
Vesicoureteric reflux 13.73 10.66 19 1248196 289 89379943
Paralysis 13.71 10.66 97 1248118 11381 89368851
Forced expiratory flow decreased 13.71 10.66 12 1248203 105 89380127
Loss of employment 13.69 10.66 79 1248136 2908 89377324
Neck mass 13.66 10.66 96 1248119 3786 89376446
Pneumothorax spontaneous 13.64 10.66 36 1248179 909 89379323
Papillary renal cell carcinoma 13.61 10.66 5 1248210 4 89380228
Extranodal marginal zone B-cell lymphoma (MALT type) stage IV 13.61 10.66 5 1248210 4 89380228
Arterial fibrosis 13.61 10.66 5 1248210 4 89380228
Infective keratitis 13.60 10.66 9 1248206 49 89380183
Arterial haemorrhage 13.59 10.66 9 1248206 2514 89377718
Haemodialysis 13.58 10.66 68 1248147 8679 89371553
Feeding disorder 13.55 10.66 165 1248050 17347 89362885
Cholecystitis acute 13.55 10.66 75 1248140 9329 89370903
Cytomegalovirus gastritis 13.54 10.66 20 1248195 324 89379908
Cogwheel rigidity 13.51 10.66 6 1248209 2096 89378136
Sneezing 13.46 10.66 521 1247694 29348 89350884
Hepatitis toxic 13.43 10.66 19 1248196 3706 89376526
Factor XIII deficiency 13.43 10.66 11 1248204 87 89380145
Cholecystitis 13.40 10.66 160 1248055 16880 89363352
Myoclonic epilepsy 13.38 10.66 3 1248212 1624 89378608
Fanconi syndrome 13.37 10.66 5 1248210 1938 89378294
Tumour lysis syndrome 13.37 10.66 222 1247993 10930 89369302
Joint dislocation reduction 13.37 10.66 6 1248209 12 89380220
B-cell lymphoma stage IV 13.37 10.66 6 1248209 12 89380220
Conjunctival irritation 13.37 10.66 6 1248209 12 89380220
Antineutrophil cytoplasmic antibody positive 13.32 10.66 31 1248184 722 89379510
Thyroid neoplasm 13.31 10.66 98 1248117 3923 89376309
Chronic graft versus host disease in eye 13.31 10.66 16 1248199 210 89380022
Palindromic rheumatism 13.30 10.66 15 1248200 183 89380049
Anogenital warts 13.29 10.66 27 1248188 571 89379661
Lymphoma 13.28 10.66 262 1247953 13329 89366903
Slow speech 13.26 10.66 5 1248210 1928 89378304
Ocular hypertension 13.25 10.66 52 1248163 1628 89378604
Hepatitis B core antibody positive 13.23 10.66 20 1248195 331 89379901
Cystitis bacterial 13.23 10.66 20 1248195 331 89379901
Anal fistula 13.22 10.66 103 1248112 4198 89376034
Enzyme level abnormal 13.22 10.66 19 1248196 300 89379932
Nasal turbinate hypertrophy 13.21 10.66 35 1248180 886 89379346
Emotional distress 13.20 10.66 394 1247821 36268 89343964
Ocular ischaemic syndrome 13.20 10.66 4 1248211 0 89380232
Incarcerated parastomal hernia 13.20 10.66 4 1248211 0 89380232
Bacterial myositis 13.20 10.66 4 1248211 0 89380232
Mantle cell lymphoma 13.17 10.66 29 1248186 650 89379582
Acute lymphocytic leukaemia recurrent 13.15 10.66 73 1248142 2648 89377584
Libido decreased 13.12 10.66 13 1248202 2969 89377263
Ankylosing spondylitis 13.12 10.66 254 1247961 12879 89367353
Phaeohyphomycotic brain abscess 13.10 10.66 5 1248210 5 89380227
Viral acanthoma 13.10 10.66 5 1248210 5 89380227
Prophylaxis against transplant rejection 13.08 10.66 8 1248207 37 89380195
Post procedural discharge 13.08 10.66 25 1248190 505 89379727
Arteriosclerosis coronary artery 13.07 10.66 78 1248137 9525 89370707
Expired product administered 13.07 10.66 50 1248165 6872 89373360
Lymphoproliferative disorder 13.06 10.66 102 1248113 4160 89376072
Type III immune complex mediated reaction 13.06 10.66 22 1248193 401 89379831
Disseminated varicella 13.06 10.66 6 1248209 13 89380219
Coxsackie virus test positive 13.06 10.66 6 1248209 13 89380219
Bladder cyst 13.06 10.66 6 1248209 13 89380219
Chronic obstructive pulmonary disease 13.06 10.66 1184 1247031 72645 89307587
Body temperature fluctuation 13.04 10.66 64 1248151 2211 89378021
Primary mediastinal large B-cell lymphoma recurrent 13.04 10.66 11 1248204 91 89380141
Electrocardiogram ST segment elevation 13.03 10.66 22 1248193 3994 89376238
Suicidal behaviour 12.97 10.66 12 1248203 2832 89377400
Bradyarrhythmia 12.96 10.66 9 1248206 2452 89377780
Mania 12.96 10.66 128 1248087 13996 89366236
Brain natriuretic peptide increased 12.94 10.66 41 1248174 5964 89374268
Ovarian cancer recurrent 12.94 10.66 3 1248212 1587 89378645
Follicular lymphoma 12.92 10.66 21 1248194 371 89379861
C3 glomerulopathy 12.91 10.66 14 1248201 163 89380069
Muscular weakness 12.90 10.66 2580 1245635 204086 89176146
Allergy to animal 12.88 10.66 51 1248164 1603 89378629
Chronic graft versus host disease in skin 12.87 10.66 42 1248173 1198 89379034
Low birth weight baby 12.83 10.66 77 1248138 9390 89370842
Ejection fraction abnormal 12.83 10.66 68 1248147 2423 89377809
Blood potassium decreased 12.80 10.66 532 1247683 47195 89333037
Breast cancer stage III 12.79 10.66 995 1247220 83452 89296780
Electrocardiogram ST segment depression 12.77 10.66 16 1248199 3287 89376945
Herpes zoster reactivation 12.76 10.66 15 1248200 192 89380040
Intestinal stenosis 12.73 10.66 83 1248132 3191 89377041
Antisynthetase syndrome 12.70 10.66 12 1248203 117 89380115
Metabolic syndrome 12.69 10.66 5 1248210 1877 89378355
Stillbirth 12.65 10.66 56 1248159 7387 89372845
Wound infection pseudomonas 12.65 10.66 6 1248209 2017 89378215
Herpes zoster meningoradiculitis 12.63 10.66 5 1248210 6 89380226
Pericardial haemorrhage 12.63 10.66 5 1248210 1871 89378361
Metastases to spine 12.62 10.66 20 1248195 3723 89376509
Aplasia pure red cell 12.59 10.66 118 1248097 5076 89375156
Rash macular 12.56 10.66 319 1247896 29961 89350271
Disseminated large cell lymphoma 12.54 10.66 9 1248206 57 89380175
Cytomegalovirus duodenitis 12.54 10.66 9 1248206 57 89380175
Avian influenza 12.52 10.66 10 1248205 76 89380156
Extradural abscess 12.50 10.66 43 1248172 1261 89378971
Social problem 12.50 10.66 42 1248173 1217 89379015
Myoglobin blood increased 12.49 10.66 3 1248212 1549 89378683
Acute hepatitis B 12.48 10.66 20 1248195 349 89379883
Prothrombin time shortened 12.44 10.66 8 1248207 2270 89377962
Graft versus host disease in lung 12.43 10.66 25 1248190 525 89379707
Cell-mediated immune deficiency 12.42 10.66 10 1248205 77 89380155
Neutrophilia 12.42 10.66 128 1248087 5650 89374582
Gastrointestinal inflammation 12.39 10.66 144 1248071 6552 89373680
Anion gap increased 12.36 10.66 8 1248207 2262 89377970
Double stranded DNA antibody positive 12.35 10.66 22 1248193 420 89379812
Viral infection 12.33 10.66 693 1247522 40721 89339511
Acute hepatitis C 12.32 10.66 10 1248205 78 89380154
Inflammatory myofibroblastic tumour 12.32 10.66 10 1248205 78 89380154
Mastitis bacterial 12.30 10.66 9 1248206 59 89380173
Cerebral venous thrombosis 12.30 10.66 64 1248151 2264 89377968
Iritis 12.30 10.66 90 1248125 3596 89376636
Peripheral coldness 12.29 10.66 127 1248088 13765 89366467
Enthesophyte 12.28 10.66 13 1248202 147 89380085
Symptom recurrence 12.27 10.66 95 1248120 3864 89376368
Hereditary angioedema 12.26 10.66 77 1248138 9288 89370944
Thrombosis 12.23 10.66 856 1247359 72395 89307837
Bladder cancer 12.22 10.66 40 1248175 5761 89374471
Ectopic pregnancy 12.22 10.66 16 1248199 3225 89377007
Photodermatosis 12.21 10.66 26 1248189 569 89379663
Incisional hernia repair 12.21 10.66 5 1248210 7 89380225
Nephropathy toxic 12.20 10.66 244 1247971 12444 89367788
Fryns syndrome 12.18 10.66 9 1248206 60 89380172
Investigation abnormal 12.17 10.66 63 1248152 2224 89378008
Primary amyloidosis 12.15 10.66 11 1248204 101 89380131
Gastroenteritis rotavirus 12.12 10.66 16 1248199 232 89380000
Birdshot chorioretinopathy 12.12 10.66 10 1248205 80 89380152
Lymphadenopathy 12.12 10.66 758 1247457 45017 89335215
Application site vesicles 12.07 10.66 3 1248212 1514 89378718
Ovarian cancer 12.07 10.66 50 1248165 6717 89373515
Colitis microscopic 12.05 10.66 97 1248118 11062 89369170
Perihepatic abscess 12.03 10.66 7 1248208 29 89380203
Pneumonia klebsiella 12.02 10.66 78 1248137 2994 89377238
Colorectal cancer 12.02 10.66 22 1248193 3871 89376361
Cyst 12.01 10.66 306 1247909 16255 89363977
Extrapulmonary tuberculosis 12.01 10.66 21 1248194 395 89379837
Osteomyelitis bacterial 11.97 10.66 16 1248199 235 89379997
Malignant anorectal neoplasm 11.97 10.66 6 1248209 17 89380215
Systemic bacterial infection 11.97 10.66 6 1248209 17 89380215
Behaviour disorder 11.96 10.66 29 1248186 4606 89375626
Nodular regenerative hyperplasia 11.95 10.66 28 1248187 655 89379577
Immunoglobulin G4 related disease 11.94 10.66 12 1248203 127 89380105
Complement factor decreased 11.93 10.66 10 1248205 82 89380150
Pulseless electrical activity 11.92 10.66 73 1248142 8859 89371373
Volume blood decreased 11.91 10.66 15 1248200 207 89380025
Localised infection 11.90 10.66 571 1247644 32991 89347241
Intervertebral disc compression 11.89 10.66 41 1248174 1204 89379028
Tracheo-oesophageal fistula 11.88 10.66 29 1248186 697 89379535
Intestinal resection 11.87 10.66 75 1248140 2852 89377380
Rheumatoid factor increased 11.86 10.66 65 1248150 2346 89377886
Joint fluid drainage 11.86 10.66 14 1248201 180 89380052
Cerebellar microhaemorrhage 11.85 10.66 7 1248208 30 89380202
Renal cancer 11.84 10.66 42 1248173 5903 89374329
Cerebellar haemorrhage 11.81 10.66 4 1248211 1649 89378583
Bipolar I disorder 11.80 10.66 7 1248208 2075 89378157
Hemianopia 11.80 10.66 7 1248208 2075 89378157
Oesophageal varices haemorrhage 11.78 10.66 3 1248212 1489 89378743
Herpes simplex encephalitis 11.75 10.66 21 1248194 402 89379830
Dacryocystitis 11.75 10.66 8 1248207 46 89380186
Clear cell renal cell carcinoma 11.73 10.66 48 1248167 1532 89378700
Social avoidant behaviour 11.73 10.66 18 1248197 3395 89376837
Pancreas transplant 11.72 10.66 6 1248209 18 89380214
Post procedural infection 11.69 10.66 216 1247999 10858 89369374
Cellulitis gangrenous 11.66 10.66 11 1248204 107 89380125
Cranial nerve palsies multiple 11.65 10.66 10 1248205 85 89380147
Mass 11.64 10.66 289 1247926 15288 89364944
Malacoplakia vesicae 11.62 10.66 9 1248206 65 89380167
Atypical haemolytic uraemic syndrome 11.61 10.66 35 1248180 956 89379276
Peptic ulcer haemorrhage 11.61 10.66 38 1248177 1086 89379146
Androgenetic alopecia 11.57 10.66 14 1248201 185 89380047
Growth retardation 11.57 10.66 52 1248163 1731 89378501
Urinary tract infection bacterial 11.56 10.66 135 1248080 6150 89374082
Hangover 11.54 10.66 8 1248207 2181 89378051
Type I hypersensitivity 11.52 10.66 25 1248190 4130 89376102
Hypoaldosteronism 11.52 10.66 19 1248196 340 89379892
Sinus polyp degeneration 11.52 10.66 9 1248206 66 89380166
Body height decreased 11.51 10.66 107 1248108 11842 89368390
Bunion operation 11.50 10.66 43 1248172 1315 89378917
Radius fracture 11.49 10.66 24 1248191 4020 89376212
Squamous cell carcinoma of the vagina 11.49 10.66 6 1248209 19 89380213
Abdominal distension 11.43 10.66 1600 1246615 129001 89251231
Myasthenia gravis 11.42 10.66 144 1248071 6681 89373551
Large intestinal stenosis 11.41 10.66 66 1248149 2431 89377801
Tongue necrosis 11.41 10.66 9 1248206 67 89380165
Blood urea decreased 11.41 10.66 12 1248203 2666 89377566
Mitral valve incompetence 11.41 10.66 230 1247985 22294 89357938
Disability 11.40 10.66 678 1247537 40067 89340165
Disease progression 11.36 10.66 2382 1245833 154233 89225999
Chorioretinal scar 11.36 10.66 8 1248207 49 89380183
Blood magnesium decreased 11.35 10.66 150 1248065 15543 89364689
Blepharospasm 11.32 10.66 636 1247579 54809 89325423
Body tinea 11.31 10.66 59 1248156 2089 89378143
Ectopic pregnancy with contraceptive device 11.31 10.66 3 1248212 1449 89378783
Haematocrit decreased 11.28 10.66 466 1247749 41366 89338866
T-lymphocyte count abnormal 11.27 10.66 6 1248209 20 89380212
Device placement issue 11.27 10.66 7 1248208 2023 89378209
Increased bronchial secretion 11.24 10.66 59 1248156 2094 89378138
Drug level above therapeutic 11.23 10.66 126 1248089 5683 89374549
Vitamin D deficiency 11.22 10.66 172 1248043 17384 89362848
Abnormal loss of weight 11.20 10.66 52 1248163 6771 89373461
Pericarditis lupus 11.19 10.66 7 1248208 34 89380198
Calcium ionised decreased 11.18 10.66 19 1248196 349 89379883
Syringe issue 11.17 10.66 24 1248191 3978 89376254
Pseudopolyp 11.15 10.66 20 1248195 384 89379848
Cavernous sinus thrombosis 11.14 10.66 15 1248200 222 89380010
Borderline leprosy 11.14 10.66 5 1248210 10 89380222
Vasodilatation 11.12 10.66 14 1248201 2870 89377362
Wrong technique in device usage process 11.11 10.66 42 1248173 5793 89374439
Breast cyst excision 11.10 10.66 9 1248206 70 89380162
Haemarthrosis 11.10 10.66 24 1248191 3970 89376262
Akinesia 11.09 10.66 5 1248210 1731 89378501
Groin pain 11.07 10.66 111 1248104 12102 89368130
Ventricular remodelling 11.06 10.66 6 1248209 21 89380211
Bone marrow granuloma 11.06 10.66 6 1248209 21 89380211
Hypotonia neonatal 11.05 10.66 3 1248212 1427 89378805
Enterobiasis 11.05 10.66 11 1248204 115 89380117
Insurance issue 11.05 10.66 97 1248118 10861 89369371
Developmental hip dysplasia 11.04 10.66 4 1248211 1581 89378651
Rhinitis perennial 11.03 10.66 7 1248208 35 89380197
Liver transplant failure 11.03 10.66 7 1248208 35 89380197
Chronic spontaneous urticaria 11.01 10.66 52 1248163 1768 89378464
Mantle cell lymphoma recurrent 11.01 10.66 20 1248195 388 89379844
Bronchitis 11.01 10.66 2325 1245890 150602 89229630
Medical device discomfort 11.00 10.66 8 1248207 2128 89378104
Microsporum infection 11.00 10.66 4 1248211 3 89380229
Actinomycotic pulmonary infection 11.00 10.66 4 1248211 3 89380229
Pleural fibrosis 10.99 10.66 86 1248129 3510 89376722
Forced expiratory volume abnormal 10.98 10.66 11 1248204 116 89380116
Skin irritation 10.98 10.66 127 1248088 13476 89366756
Haemorrhagic stroke 10.97 10.66 49 1248166 6447 89373785
Cardioactive drug level increased 10.95 10.66 10 1248205 2374 89377858
Pneumatosis intestinalis 10.95 10.66 83 1248132 3354 89376878
Psychotic symptom 10.92 10.66 9 1248206 2247 89377985
Gastrosplenic fistula 10.91 10.66 9 1248206 72 89380160
Septal panniculitis 10.91 10.66 9 1248206 72 89380160
Crepitations 10.91 10.66 177 1248038 8675 89371557
Varicella zoster pneumonia 10.90 10.66 11 1248204 117 89380115
Blood triglycerides increased 10.90 10.66 129 1248086 13632 89366600
Embolic stroke 10.89 10.66 25 1248190 4047 89376185
Laryngeal mass 10.88 10.66 7 1248208 36 89380196
Bacteroides bacteraemia 10.87 10.66 8 1248207 53 89380179
Myocardial necrosis 10.87 10.66 14 1248201 198 89380034
Meningitis fungal 10.87 10.66 10 1248205 94 89380138
Myocardiac abscess 10.85 10.66 6 1248209 22 89380210
Spirometry abnormal 10.84 10.66 16 1248199 259 89379973
Cerebrospinal fluid leakage 10.84 10.66 4 1248211 1563 89378669
Bacterial pericarditis 10.83 10.66 5 1248210 11 89380221
Vascular rupture 10.82 10.66 52 1248163 1781 89378451
Respiratory tract infection fungal 10.82 10.66 23 1248192 503 89379729
Ileectomy 10.80 10.66 17 1248198 292 89379940
Eye disorder 10.80 10.66 471 1247744 26919 89353313
International normalised ratio abnormal 10.78 10.66 23 1248192 3822 89376410
Adrenocortical insufficiency acute 10.77 10.66 67 1248148 2534 89377698
Anal fistula infection 10.73 10.66 7 1248208 37 89380195
Hyperlipidaemia 10.73 10.66 237 1247978 22679 89357553
Oligoarthritis 10.73 10.66 24 1248191 544 89379688
Cervicitis 10.73 10.66 24 1248191 544 89379688
Injection site warmth 10.72 10.66 173 1248042 17342 89362890
Genital lesion 10.71 10.66 16 1248199 262 89379970
Anticonvulsant drug level decreased 10.70 10.66 3 1248212 1397 89378835
Nocturia 10.68 10.66 90 1248125 10165 89370067
Staphylococcal infection 10.68 10.66 790 1247425 47649 89332583
Medical device pain 10.67 10.66 4 1248211 1548 89378684
Gastroenteritis viral 10.67 10.66 516 1247699 29839 89350393

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1307.17 12.22 12660 506830 625675 41476170
Colitis ulcerative 1119.09 12.22 1485 518005 24690 42077155
Drug ineffective 1113.82 12.22 12132 507358 618065 41483780
Drug abuse 896.17 12.22 111 519379 104660 41997185
Asthma 684.87 12.22 1987 517503 60327 42041518
Nocardiosis 681.42 12.22 540 518950 4650 42097195
Completed suicide 676.05 12.22 171 519319 96294 42005551
Transplant rejection 673.79 12.22 830 518660 12758 42089087
Condition aggravated 631.08 12.22 5373 514117 255381 41846464
Post transplant lymphoproliferative disorder 563.93 12.22 624 518866 8496 42093349
Polyomavirus-associated nephropathy 509.98 12.22 473 519017 5142 42096703
Overdose 499.03 12.22 335 519155 104929 41996916
Wheezing 493.37 12.22 1630 517860 53151 42048694
Therapeutic product effect incomplete 486.26 12.22 1931 517559 69008 42032837
Disease recurrence 455.91 12.22 1073 518417 28605 42073240
Pneumocystis jirovecii pneumonia 451.23 12.22 968 518522 24213 42077632
Rheumatoid arthritis 442.01 12.22 1328 518162 41112 42060733
Toxicity to various agents 435.56 12.22 1389 518101 227747 41874098
Cytomegalovirus infection 423.27 12.22 1099 518391 31207 42070638
Disease progression 422.42 12.22 3098 516392 140558 41961287
Intentional overdose 419.70 12.22 63 519427 51393 42050452
Death 419.48 12.22 3702 515788 467483 41634362
Aspergillus infection 411.92 12.22 713 518777 15124 42086721
Rebound effect 387.38 12.22 464 519026 6915 42094930
Kidney transplant rejection 387.03 12.22 503 518987 8180 42093665
Somnolence 385.35 12.22 707 518783 140398 41961447
Intentional product use issue 384.53 12.22 1815 517675 70018 42031827
Bradycardia 379.02 12.22 292 519198 85192 42016653
Malacoplakia 366.65 12.22 193 519297 731 42101114
Histoplasmosis disseminated 364.76 12.22 258 519232 1833 42100012
Cryptococcosis 328.01 12.22 289 519201 2922 42098923
Fall 326.90 12.22 1608 517882 232912 41868933
Loss of personal independence in daily activities 323.69 12.22 1334 518156 48482 42053363
Drug effective for unapproved indication 322.11 12.22 401 519089 6232 42095613
Obstructive airways disorder 314.84 12.22 833 518657 23926 42077919
Strongyloidiasis 313.47 12.22 290 519200 3141 42098704
Frequent bowel movements 304.10 12.22 751 518739 20656 42081189
Cytomegalovirus viraemia 301.58 12.22 491 518999 9886 42091959
Diffuse large B-cell lymphoma recurrent 299.81 12.22 333 519157 4553 42097292
Phaeohyphomycosis 298.84 12.22 184 519306 1000 42100845
Hypotension 294.67 12.22 1885 517605 255746 41846099
Dizziness 279.80 12.22 1834 517656 247420 41854425
Full blood count abnormal 279.69 12.22 901 518589 28975 42072870
Productive cough 259.32 12.22 1280 518210 50287 42051558
Sleep disorder due to a general medical condition 258.25 12.22 622 518868 16831 42085014
Product use in unapproved indication 253.37 12.22 3394 516096 181062 41920783
Seizure 247.97 12.22 704 518786 119857 41981988
Blastomycosis 245.62 12.22 135 519355 569 42101276
Treatment failure 244.82 12.22 1451 518039 61173 42040672
Nausea 244.18 12.22 3389 516101 393410 41708435
Suicide attempt 240.32 12.22 131 519359 45969 42055876
Mucormycosis 235.31 12.22 358 519132 6785 42095060
Hypoglycaemia 233.12 12.22 231 519259 59623 42042222
Intentional product misuse 228.58 12.22 250 519240 61650 42040195
Epstein-Barr virus infection 227.64 12.22 418 519072 9300 42092545
Loss of consciousness 226.84 12.22 492 518998 91862 42009983
Confusional state 226.52 12.22 1161 518329 166436 41935409
Sedation 225.33 12.22 48 519442 30427 42071418
COVID-19 224.95 12.22 2281 517209 113667 41988178
Pulmonary nocardiosis 217.66 12.22 179 519311 1633 42100212
Hyponatraemia 211.93 12.22 588 518902 100874 42000971
Vomiting 210.35 12.22 2388 517102 287335 41814510
Constipation 209.96 12.22 1141 518349 161150 41940695
Electrocardiogram QT prolonged 207.12 12.22 168 519322 47777 42054068
Therapy partial responder 204.15 12.22 622 518868 19399 42082446
Coma 203.64 12.22 211 519279 53343 42048502
Blood pressure fluctuation 202.66 12.22 755 518735 26153 42075692
Human herpesvirus 8 infection 201.33 12.22 158 519332 1339 42100506
Histoplasmosis 199.06 12.22 169 519321 1618 42100227
Cardio-respiratory arrest 195.04 12.22 257 519233 58379 42043466
Agitation 195.01 12.22 301 519189 64013 42037832
Aggression 194.22 12.22 152 519338 44011 42057834
Brain abscess 192.21 12.22 249 519241 4035 42097810
General physical health deterioration 190.88 12.22 1072 518418 150174 41951671
Drug level below therapeutic 189.26 12.22 309 519181 6236 42095609
Rhabdomyolysis 188.81 12.22 419 519071 77600 42024245
Complications of transplanted kidney 187.47 12.22 276 519214 5074 42096771
Cytomegalovirus colitis 187.45 12.22 237 519253 3744 42098101
Progressive multifocal leukoencephalopathy 186.90 12.22 426 519064 11110 42090735
Myocardial infarction 186.83 12.22 826 518664 123183 41978662
Meningitis cryptococcal 186.54 12.22 215 519275 3068 42098777
Arthralgia 185.85 12.22 3523 515967 201715 41900130
Hallucination 185.26 12.22 258 519232 57249 42044596
Serotonin syndrome 184.47 12.22 44 519446 25801 42076044
Hepatic function abnormal 184.13 12.22 214 519276 51353 42050492
Blood creatine phosphokinase increased 183.17 12.22 191 519299 48147 42053698
West Nile viral infection 180.79 12.22 122 519368 795 42101050
Depressed level of consciousness 179.03 12.22 192 519298 47778 42054067
Disseminated cryptococcosis 178.37 12.22 164 519326 1761 42100084
Bronchopulmonary aspergillosis 176.47 12.22 580 518910 18849 42082996
Suicidal ideation 175.07 12.22 197 519293 47964 42053881
Drug level decreased 173.50 12.22 379 519111 9598 42092247
Neuroleptic malignant syndrome 173.44 12.22 27 519463 21445 42080400
Osteoporosis 172.99 12.22 485 519005 14421 42087424
Transplant dysfunction 171.85 12.22 208 519282 3135 42098710
Weight increased 164.56 12.22 2026 517464 105957 41995888
Bronchiectasis 161.95 12.22 536 518954 17483 42084362
Escherichia infection 159.94 12.22 398 519092 10998 42090847
Alternaria infection 159.88 12.22 97 519393 511 42101334
Syncope 158.39 12.22 648 518842 98758 42003087
Immunosuppressant drug level increased 155.82 12.22 312 519178 7419 42094426
BK virus infection 155.39 12.22 336 519154 8448 42093397
Pseudomonas infection 153.37 12.22 485 519005 15438 42086407
Focal segmental glomerulosclerosis 151.78 12.22 171 519319 2377 42099468
Extrapyramidal disorder 151.54 12.22 13 519477 16399 42085446
Steroid diabetes 147.50 12.22 178 519312 2674 42099171
Respiratory depression 147.34 12.22 26 519464 18842 42083003
Hepatitis B reactivation 145.95 12.22 226 519264 4352 42097493
Joint swelling 144.93 12.22 1365 518125 66657 42035188
Drug ineffective for unapproved indication 144.32 12.22 1011 518479 45152 42056693
Disseminated blastomycosis 143.50 12.22 78 519412 320 42101525
Restlessness 142.68 12.22 90 519400 29159 42072686
Defaecation urgency 141.78 12.22 199 519291 3495 42098350
Angioedema 139.39 12.22 188 519302 42289 42059556
Rash 139.33 12.22 2456 517034 274498 41827347
Sputum discoloured 137.11 12.22 349 519141 9783 42092062
Delirium 136.32 12.22 271 519219 52248 42049597
Ventricular fibrillation 134.58 12.22 102 519388 30021 42071824
Renal transplant failure 133.23 12.22 125 519365 1380 42100465
Polyomavirus viraemia 133.14 12.22 146 519344 1966 42099879
JC virus infection 132.28 12.22 173 519317 2831 42099014
Acute kidney injury 130.94 12.22 3443 516047 363894 41737951
Cardiac arrest 130.29 12.22 789 518701 108531 41993314
Altered state of consciousness 129.54 12.22 100 519390 29159 42072686
Drug interaction 129.14 12.22 2384 517106 264615 41837230
Therapeutic product effect decreased 128.05 12.22 867 518623 38283 42063562
Cough 126.79 12.22 2952 516538 175151 41926694
Faecal calprotectin increased 126.75 12.22 172 519318 2922 42098923
Pneumonia cryptococcal 125.42 12.22 121 519369 1387 42100458
International normalised ratio increased 124.63 12.22 249 519241 47919 42053926
Mycobacterium avium complex infection 123.58 12.22 168 519322 2859 42098986
Pneumonia aspiration 123.56 12.22 266 519224 49812 42052033
Infection reactivation 123.51 12.22 143 519347 2051 42099794
White blood cell count decreased 123.22 12.22 813 518677 109583 41992262
Tachycardia 120.24 12.22 730 518760 100357 42001488
Lymphadenopathy 120.16 12.22 757 518733 32608 42069237
Haemophagocytic lymphohistiocytosis 119.90 12.22 490 519000 17732 42084113
Inappropriate schedule of product administration 119.83 12.22 1736 517754 94166 42007679
Miosis 117.96 12.22 13 519477 13433 42088412
Therapeutic reaction time decreased 117.92 12.22 136 519354 1942 42099903
Chronic allograft nephropathy 117.68 12.22 120 519370 1478 42100367
Cardiac failure 117.21 12.22 791 518699 106065 41995780
Varicella zoster virus infection 116.41 12.22 151 519339 2450 42099395
Haematochezia 116.28 12.22 1156 518334 57280 42044565
Candida infection 114.76 12.22 545 518945 21065 42080780
Lung transplant rejection 114.55 12.22 98 519392 949 42100896
Therapy non-responder 113.77 12.22 1071 518419 52288 42049557
Septic shock 111.61 12.22 1652 517838 90020 42011825
Lactic acidosis 108.71 12.22 244 519246 45017 42056828
Acute respiratory distress syndrome 108.36 12.22 683 518807 29425 42072420
Incorrect route of product administration 107.68 12.22 83 519407 24222 42077623
Platelet count decreased 106.78 12.22 1126 518364 137455 41964390
Trichodysplasia spinulosa 106.70 12.22 64 519426 329 42101516
Abnormal behaviour 106.56 12.22 99 519391 26352 42075493
Circulatory collapse 105.63 12.22 80 519410 23556 42078289
Intentional self-injury 104.40 12.22 28 519462 15174 42086671
Dehydration 103.99 12.22 1165 518325 140602 41961243
Weight decreased 103.89 12.22 3292 516198 204656 41897189
Decreased appetite 103.73 12.22 1692 517798 191445 41910400
Cryptosporidiosis infection 103.55 12.22 82 519408 705 42101140
Kidney fibrosis 103.52 12.22 146 519344 2576 42099269
Respiratory arrest 102.49 12.22 117 519373 28307 42073538
Epistaxis 102.46 12.22 442 519048 66384 42035461
Bacillary angiomatosis 101.90 12.22 51 519439 169 42101676
Mycobacterium haemophilum infection 100.93 12.22 65 519425 387 42101458
Palmar-plantar erythrodysaesthesia syndrome 100.85 12.22 63 519427 20519 42081326
Disseminated tuberculosis 100.85 12.22 147 519343 2677 42099168
Anaphylactic shock 100.81 12.22 83 519407 23434 42078411
Dysarthria 99.40 12.22 210 519280 39597 42062248
Poisoning 99.21 12.22 28 519462 14671 42087174
Clostridium difficile infection 99.00 12.22 541 518949 22118 42079727
Monkeypox 98.58 12.22 62 519428 352 42101493
Vaccination failure 98.47 12.22 105 519385 1367 42100478
Colitis 98.39 12.22 933 518557 45639 42056206
Schizophrenia 98.39 12.22 8 519482 10542 42091303
Cerebral infarction 98.22 12.22 142 519348 31027 42070818
Disturbance in attention 98.17 12.22 132 519358 29734 42072111
Neutrophil count decreased 98.11 12.22 418 519072 62997 42038848
Heart rate decreased 97.11 12.22 770 518720 35762 42066083
Scedosporium infection 96.99 12.22 107 519383 1451 42100394
Fungal infection 96.58 12.22 486 519004 19236 42082609
Dyskinesia 96.54 12.22 100 519390 25290 42076555
Epstein-Barr viraemia 96.44 12.22 129 519361 2160 42099685
Cat scratch disease 96.42 12.22 58 519432 300 42101545
Forced expiratory volume decreased 96.25 12.22 256 519234 7374 42094471
Hyperhidrosis 95.80 12.22 677 518813 89835 42012010
Substance abuse 94.78 12.22 3 519487 8902 42092943
Product prescribing error 94.67 12.22 107 519383 26005 42075840
Posterior reversible encephalopathy syndrome 94.25 12.22 357 519133 12464 42089381
Renal tubular atrophy 94.19 12.22 102 519388 1353 42100492
Human ehrlichiosis 94.02 12.22 65 519425 443 42101402
Mycobacterial infection 94.00 12.22 138 519352 2530 42099315
Diffuse large B-cell lymphoma 93.84 12.22 291 519199 9163 42092682
Disorientation 93.37 12.22 189 519301 36200 42065645
Nasal congestion 93.31 12.22 648 518842 28853 42072992
Wrong technique in product usage process 92.79 12.22 242 519248 42393 42059452
American trypanosomiasis 91.57 12.22 56 519434 300 42101545
Osteonecrosis 91.55 12.22 410 519080 15455 42086390
Orthostatic hypotension 90.80 12.22 145 519345 30425 42071420
Cognitive disorder 90.69 12.22 174 519316 33998 42067847
Pulmonary mass 90.62 12.22 416 519074 15849 42085996
Dry mouth 89.38 12.22 223 519267 39656 42062189
Ascites 89.28 12.22 371 519119 56307 42045538
Graft loss 88.79 12.22 80 519410 835 42101010
Unresponsive to stimuli 88.60 12.22 154 519336 31249 42070596
Mucous stools 87.50 12.22 130 519360 2410 42099435
Enterococcal infection 87.49 12.22 334 519156 11705 42090140
Humoral immune defect 87.07 12.22 55 519435 315 42101530
Hypogammaglobulinaemia 86.50 12.22 330 519160 11561 42090284
Adenovirus infection 85.43 12.22 228 519262 6581 42095264
Blood immunoglobulin E increased 84.99 12.22 156 519334 3469 42098376
Cerebrovascular accident 84.24 12.22 767 518723 96393 42005452
Hyperkalaemia 84.07 12.22 604 518886 79854 42021991
Memory impairment 84.01 12.22 321 519169 49901 42051944
Hallucination, auditory 83.84 12.22 38 519452 14826 42087019
Tremor 83.25 12.22 767 518723 96162 42005683
Eosinophilic granulomatosis with polyangiitis 83.08 12.22 263 519227 8375 42093470
Immunosuppression 82.80 12.22 259 519231 8194 42093651
Herpes zoster 82.69 12.22 780 518710 38097 42063748
Therapeutic response shortened 82.56 12.22 356 519134 13198 42088647
Mycobacterium chelonae infection 82.31 12.22 86 519404 1092 42100753
Aspartate aminotransferase increased 81.72 12.22 577 518913 76586 42025259
Fungal skin infection 81.15 12.22 146 519344 3195 42098650
Cushingoid 79.90 12.22 147 519343 3275 42098570
Parvovirus B19 infection 79.69 12.22 102 519388 1632 42100213
Cerebral haemorrhage 79.68 12.22 228 519262 38738 42063107
Pneumonia cytomegaloviral 78.98 12.22 163 519327 3963 42097882
Ureaplasma infection 78.86 12.22 64 519426 572 42101273
Impaired quality of life 78.54 12.22 362 519128 13815 42088030
Legionella infection 78.30 12.22 62 519428 533 42101312
Pseudoaneurysm infection 77.70 12.22 42 519448 170 42101675
Coronary artery disease 77.13 12.22 364 519126 53356 42048489
Stevens-Johnson syndrome 77.05 12.22 94 519396 22084 42079761
Cardiogenic shock 77.02 12.22 203 519287 35437 42066408
Drug use disorder 76.94 12.22 16 519474 10317 42091528
Pruritus 76.70 12.22 1734 517756 187037 41914808
Heart transplant rejection 76.51 12.22 94 519396 1440 42100405
Akathisia 76.16 12.22 17 519473 10434 42091411
Infection 76.14 12.22 1846 517644 110222 41991623
Paranoia 75.83 12.22 38 519452 13988 42087857
Diffuse large B-cell lymphoma refractory 75.78 12.22 107 519383 1890 42099955
Product dose omission issue 75.21 12.22 1376 518114 152989 41948856
Pulmonary function test decreased 75.04 12.22 195 519295 5537 42096308
Herpes simplex 74.74 12.22 223 519267 6872 42094973
Nasal polyps 74.74 12.22 153 519337 3698 42098147
Pneumocystis jirovecii infection 74.66 12.22 129 519361 2731 42099114
Drug withdrawal syndrome 74.17 12.22 92 519398 21457 42080388
Erectile dysfunction 74.15 12.22 118 519372 24795 42077050
Depression 73.63 12.22 936 518554 110427 41991418
Steroid dependence 73.41 12.22 214 519276 6508 42095337
Dystonia 73.24 12.22 32 519458 12758 42089087
Visceral leishmaniasis 73.13 12.22 80 519410 1074 42100771
Haematotoxicity 72.74 12.22 296 519194 10689 42091156
Muscle rigidity 72.57 12.22 28 519462 12031 42089814
Abscess 72.52 12.22 355 519135 13893 42087952
Balance disorder 72.49 12.22 316 519174 47329 42054516
Hepatitis E 72.38 12.22 134 519356 3000 42098845
Nightmare 72.08 12.22 121 519369 24891 42076954
Lymphopenia 71.98 12.22 480 519010 21083 42080762
Liver disorder 71.86 12.22 245 519245 39399 42062446
Night sweats 71.85 12.22 453 519037 19516 42082329
Cerebral aspergillosis 71.60 12.22 98 519392 1679 42100166
Uveitis 71.56 12.22 262 519228 8996 42092849
Arthropathy 71.23 12.22 610 518880 28987 42072858
Diarrhoea 71.22 12.22 4751 514739 456098 41645747
Poisoning deliberate 70.86 12.22 18 519472 10116 42091729
Activated partial thromboplastin time prolonged 70.84 12.22 54 519436 15849 42085996
Haematemesis 70.73 12.22 165 519325 30034 42071811
Foetal exposure during pregnancy 70.64 12.22 316 519174 46995 42054850
Disseminated mucormycosis 70.61 12.22 86 519404 1305 42100540
Irritability 70.55 12.22 148 519342 27980 42073865
Asthma-chronic obstructive pulmonary disease overlap syndrome 70.54 12.22 91 519399 1468 42100377
Hypomagnesaemia 70.53 12.22 151 519339 28337 42073508
Respiratory failure 70.20 12.22 2052 517438 126080 41975765
Philadelphia positive chronic myeloid leukaemia 69.49 12.22 35 519455 118 42101727
Pulmonary mucormycosis 69.11 12.22 87 519403 1368 42100477
Encephalitis viral 68.84 12.22 89 519401 1439 42100406
Babesiosis 68.81 12.22 40 519450 192 42101653
Lymphoma 68.78 12.22 351 519139 13970 42087875
Mydriasis 68.66 12.22 12 519478 8758 42093087
Psychotic disorder 68.08 12.22 160 519330 29048 42072797
Hepatitis B 67.94 12.22 208 519282 6503 42095342
Intercepted product preparation error 67.82 12.22 6 519484 7383 42094462
Osteopenia 67.73 12.22 199 519291 6079 42095766
Vascular pseudoaneurysm ruptured 67.17 12.22 52 519438 431 42101414
Arthritis bacterial 67.17 12.22 190 519300 5678 42096167
Pneumoperitoneum 67.04 12.22 111 519379 2267 42099578
Febrile neutropenia 66.85 12.22 2834 516656 182869 41918976
Acute myocardial infarction 66.56 12.22 425 519065 57740 42044105
Cryptococcal cutaneous infection 66.21 12.22 35 519455 134 42101711
Appendicitis 65.84 12.22 93 519397 20520 42081325
Sinus bradycardia 65.44 12.22 51 519439 14802 42087043
Rhodococcus infection 65.29 12.22 45 519445 305 42101540
Anaemia 64.94 12.22 2774 516716 277504 41824341
Necrotising oesophagitis 64.49 12.22 69 519421 902 42100943
Klebsiella infection 64.00 12.22 291 519199 11041 42090804
Coccidioidomycosis 63.97 12.22 65 519425 797 42101048
Sinus pain 63.44 12.22 67 519423 862 42100983
Squamous cell carcinoma of skin 63.29 12.22 315 519175 12411 42089434
Melaena 63.29 12.22 250 519240 38496 42063349
Eosinophil count abnormal 63.25 12.22 45 519445 323 42101522
Blood phosphorus increased 63.23 12.22 37 519453 12488 42089357
Renal graft infection 63.16 12.22 46 519444 344 42101501
Fistula 62.93 12.22 226 519264 7686 42094159
Prostatic specific antigen increased 62.80 12.22 387 519103 16538 42085307
Loss of therapeutic response 62.60 12.22 78 519412 1213 42100632
Arthritis 62.60 12.22 786 518704 41279 42060566
Bronchial wall thickening 62.50 12.22 80 519410 1280 42100565
Malignant fibrous histiocytoma 62.00 12.22 40 519450 239 42101606
Blood pressure increased 61.88 12.22 1654 517836 100274 42001571
Pulmonary oedema 61.59 12.22 388 519102 52884 42048961
Poor venous access 60.99 12.22 211 519279 7041 42094804
Drug eruption 60.79 12.22 118 519372 22957 42078888
Myoclonus 60.70 12.22 71 519419 16994 42084851
Gastroenteritis norovirus 60.53 12.22 89 519401 1634 42100211
COVID-19 pneumonia 60.45 12.22 461 519029 21152 42080693
Toxic epidermal necrolysis 60.39 12.22 149 519341 26601 42075244
B-cell lymphoma recurrent 60.35 12.22 63 519427 799 42101046
Parkinsonism 60.16 12.22 27 519463 10596 42091249
Accidental overdose 59.97 12.22 163 519327 28167 42073678
Withdrawal syndrome 59.87 12.22 55 519435 14720 42087125
Cardiac failure congestive 59.78 12.22 711 518779 84891 42016954
Gamma-glutamyltransferase increased 59.46 12.22 200 519290 32297 42069548
Disseminated strongyloidiasis 59.03 12.22 50 519440 477 42101368
Alanine aminotransferase increased 58.82 12.22 742 518748 87664 42014181
Inflammation 58.56 12.22 651 518839 33196 42068649
Sensitivity to weather change 58.45 12.22 96 519394 1947 42099898
Amnesia 58.43 12.22 166 519324 28271 42073574
Epstein-Barr virus associated lymphoproliferative disorder 58.37 12.22 106 519384 2337 42099508
Epilepsy 58.13 12.22 147 519343 26024 42075821
Epidermodysplasia verruciformis 57.93 12.22 39 519451 253 42101592
Drug reaction with eosinophilia and systemic symptoms 57.56 12.22 290 519200 41785 42060060
Labelled drug-drug interaction medication error 57.42 12.22 63 519427 15519 42086326
Drug specific antibody present 57.36 12.22 141 519349 3865 42097980
Salivary hypersecretion 57.15 12.22 31 519459 10912 42090933
Subdural haematoma 56.98 12.22 123 519367 23015 42078830
Hyperphosphataemia 56.85 12.22 45 519445 12959 42088886
Bladder cancer 56.37 12.22 75 519415 16972 42084873
Blood bilirubin increased 56.23 12.22 294 519196 41958 42059887
Pulmonary function test abnormal 55.83 12.22 110 519380 2584 42099261
Gastrointestinal haemorrhage 55.80 12.22 846 518644 96880 42004965
Empyema 55.54 12.22 143 519347 4037 42097808
Central nervous system lymphoma 55.23 12.22 76 519414 1309 42100536
Central nervous system infection 54.97 12.22 61 519429 833 42101012
Hallucination, visual 54.93 12.22 108 519382 20912 42080933
Musculoskeletal stiffness 54.68 12.22 999 518491 56766 42045079
Enterovirus infection 54.67 12.22 73 519417 1220 42100625
Hypophosphataemia 54.40 12.22 108 519382 20837 42081008
Asphyxia 54.12 12.22 17 519473 8309 42093536
Obstruction 54.09 12.22 118 519372 2985 42098860
Generalised tonic-clonic seizure 53.45 12.22 155 519335 26224 42075621
Graft versus host disease in lung 52.97 12.22 55 519435 693 42101152
Syringe issue 52.94 12.22 19 519471 8537 42093308
Delusion 52.73 12.22 61 519429 14673 42087172
Oedema peripheral 52.69 12.22 1259 518231 134817 41967028
Delayed graft function 52.69 12.22 106 519384 2529 42099316
Crohn's disease 52.62 12.22 114 519376 2870 42098975
Product administration error 52.61 12.22 89 519401 18254 42083591
Muscle spasms 52.56 12.22 735 518755 85309 42016536
Cytomegalovirus infection reactivation 52.31 12.22 272 519218 10906 42090939
Toxic skin eruption 52.28 12.22 54 519436 13676 42088169
Hepatic cytolysis 52.05 12.22 161 519329 26683 42075162
Myocardial ischaemia 52.04 12.22 85 519405 17677 42084168
Product substitution issue 52.02 12.22 37 519453 11253 42090592
Leukopenia 51.88 12.22 1235 518255 73511 42028334
Bronchial obstruction 51.85 12.22 83 519407 1646 42100199
Blood pressure diastolic increased 51.83 12.22 184 519306 6221 42095624
Staphylococcal infection 51.65 12.22 693 518797 36950 42064895
Osteomyelitis fungal 51.27 12.22 39 519451 314 42101531
Arrhythmia 51.18 12.22 285 519205 40032 42061813
Obsessive-compulsive disorder 51.13 12.22 10 519480 6733 42095112
Device leakage 51.05 12.22 31 519459 10254 42091591
Disseminated varicella zoster virus infection 50.99 12.22 55 519435 726 42101119
Euglycaemic diabetic ketoacidosis 50.87 12.22 5 519485 5655 42096190
Urinary retention 50.60 12.22 304 519186 41910 42059935
Cytomegalovirus chorioretinitis 50.55 12.22 147 519343 4464 42097381
Stenotrophomonas infection 50.55 12.22 128 519362 3576 42098269
Dry skin 50.41 12.22 363 519127 47975 42053870
Mycoplasma infection 50.37 12.22 50 519440 595 42101250
Drug level above therapeutic 49.81 12.22 172 519318 5734 42096111
Pneumonia pseudomonal 49.55 12.22 152 519338 4757 42097088
Palpitations 49.40 12.22 389 519101 50408 42051437
Therapeutic response decreased 49.40 12.22 678 518812 36334 42065511
Colectomy 49.36 12.22 96 519394 2233 42099612
Disseminated coccidioidomycosis 49.27 12.22 25 519465 86 42101759
Blood immunoglobulin A decreased 48.78 12.22 51 519439 648 42101197
Anaphylactic reaction 48.03 12.22 314 519176 42429 42059416
Sopor 47.96 12.22 54 519436 13148 42088697
Chest pain 47.61 12.22 1315 518175 138215 41963630
Skin mass 47.57 12.22 148 519342 4668 42097177
Tuberculosis 47.44 12.22 246 519244 9853 42091992
Suspected suicide 47.41 12.22 9 519481 6190 42095655
Medication error 47.38 12.22 225 519265 32929 42068916
Body temperature decreased 47.00 12.22 319 519171 14094 42087751
Joint stiffness 46.50 12.22 283 519207 12039 42089806
Epstein-Barr virus associated lymphoma 46.33 12.22 61 519429 1005 42100840
Skin lesion 46.26 12.22 521 518969 26653 42075192
Complications of transplanted lung 46.25 12.22 36 519454 301 42101544
Speech disorder 45.61 12.22 191 519299 28930 42072915
Allergy to animal 45.49 12.22 44 519446 506 42101339
Acanthamoeba infection 45.46 12.22 43 519447 480 42101365
Tardive dyskinesia 45.25 12.22 14 519476 6910 42094935
Muscle twitching 45.23 12.22 46 519444 11734 42090111
Blood uric acid increased 44.99 12.22 75 519415 15472 42086373
Cerebral fungal infection 44.95 12.22 37 519453 338 42101507
Cutaneous mucormycosis 44.91 12.22 47 519443 598 42101247
Myopathy 44.53 12.22 304 519186 13457 42088388
Liver transplant rejection 44.30 12.22 96 519394 2417 42099428
Accidental exposure to product 44.17 12.22 116 519374 20277 42081568
Acquired apparent mineralocorticoid excess 44.16 12.22 22 519468 72 42101773
Second primary malignancy 44.12 12.22 232 519258 9343 42092502
Chronic sinusitis 44.00 12.22 115 519375 3277 42098568
Human polyomavirus infection 43.90 12.22 66 519424 1237 42100608
Granulomatosis with polyangiitis 43.90 12.22 71 519419 1421 42100424
Dust allergy 43.86 12.22 154 519336 5178 42096667
Pneumonia fungal 43.80 12.22 224 519266 8922 42092923
Dysphagia 43.76 12.22 623 518867 72096 42029749
Nephropathy toxic 43.70 12.22 353 519137 16485 42085360
Coombs positive haemolytic anaemia 43.68 12.22 64 519426 1171 42100674
Upper gastrointestinal haemorrhage 43.66 12.22 205 519285 30094 42071751
Priapism 43.62 12.22 12 519478 6395 42095450
Heart rate irregular 43.58 12.22 340 519150 15710 42086135
Blood pressure systolic increased 43.51 12.22 527 518963 27441 42074404
Ventricular tachycardia 43.50 12.22 204 519286 29956 42071889
Rheumatoid factor positive 43.45 12.22 52 519438 774 42101071
Product quality issue 43.26 12.22 96 519394 17786 42084059
Pneumonia necrotising 43.24 12.22 60 519430 1042 42100803
Multiple sclerosis relapse 42.98 12.22 67 519423 14197 42087648
Cutaneous nocardiosis 42.97 12.22 29 519461 189 42101656
Dermatophytosis 42.97 12.22 33 519457 270 42101575
Myelodysplastic syndrome 42.85 12.22 445 519045 22300 42079545
Mycobacterium marinum infection 42.75 12.22 42 519448 493 42101352
Squamous cell carcinoma 42.73 12.22 288 519202 12694 42089151
Listeriosis 42.68 12.22 68 519422 1343 42100502
Trichophytosis 42.55 12.22 37 519453 367 42101478
New onset diabetes after transplantation 42.37 12.22 29 519461 194 42101651
Lymphadenitis 42.09 12.22 94 519396 2417 42099428
Sexual dysfunction 42.00 12.22 15 519475 6760 42095085
Vascular hyalinosis 41.97 12.22 24 519466 111 42101734
Abdominal abscess 41.81 12.22 147 519343 4946 42096899
Mycobacterium fortuitum infection 41.53 12.22 37 519453 380 42101465
Impaired work ability 41.47 12.22 271 519219 11820 42090025
Sinusitis 41.36 12.22 808 518682 46484 42055361
Abnormal dreams 40.96 12.22 25 519465 8246 42093599
Electrocardiogram abnormal 40.82 12.22 38 519452 10107 42091738
Aphthous ulcer 40.66 12.22 161 519329 5740 42096105
Cataract 40.59 12.22 560 518930 30044 42071801
Acute respiratory failure 40.34 12.22 682 518808 38176 42063669
Medial tibial stress syndrome 40.11 12.22 18 519472 43 42101802
Aspiration 40.08 12.22 100 519390 17786 42084059
Psychiatric decompensation 39.94 12.22 3 519487 4219 42097626
Lethargy 39.82 12.22 372 519118 46518 42055327
Blood alkaline phosphatase increased 39.71 12.22 243 519247 33354 42068491
Disseminated mycobacterium avium complex infection 39.70 12.22 29 519461 218 42101627
Nodular regenerative hyperplasia 39.54 12.22 56 519434 992 42100853
Head injury 39.51 12.22 124 519366 20458 42081387
Small for dates baby 39.50 12.22 8 519482 5255 42096590
Smooth muscle cell neoplasm 39.47 12.22 31 519459 263 42101582
Insomnia 39.43 12.22 1118 518372 117135 41984710
Haematuria 39.22 12.22 483 519007 57316 42044529
Injection site pain 39.22 12.22 483 519007 57315 42044530
Bradypnoea 39.17 12.22 4 519486 4389 42097456
Muscle spasticity 39.17 12.22 17 519473 6805 42095040
Status epilepticus 39.03 12.22 82 519408 15496 42086349
Pancreatic carcinoma 38.97 12.22 35 519455 9471 42092374
Superinfection bacterial 38.86 12.22 65 519425 1339 42100506
Hiccups 38.78 12.22 55 519435 12116 42089729
Tuberculosis gastrointestinal 38.77 12.22 29 519461 227 42101618
Sporotrichosis 38.63 12.22 19 519471 60 42101785
Psychomotor hyperactivity 38.54 12.22 46 519444 10912 42090933
Right atrial hypertrophy 38.12 12.22 46 519444 691 42101154
Steroid withdrawal syndrome 38.11 12.22 31 519459 278 42101567
Gastrointestinal inflammation 38.09 12.22 133 519357 4459 42097386
Metabolic acidosis 38.03 12.22 426 519064 51432 42050413
Hypofibrinogenaemia 38.00 12.22 78 519412 1889 42099956
Full blood count decreased 37.98 12.22 126 519364 20434 42081411
Foot deformity 37.98 12.22 142 519348 4926 42096919
Cerebral toxoplasmosis 37.97 12.22 81 519409 2017 42099828
Hyperthermia 37.95 12.22 59 519431 12515 42089330
Bordetella infection 37.90 12.22 25 519465 156 42101689
Prescribed overdose 37.74 12.22 62 519428 12865 42088980
Listeria encephalitis 37.74 12.22 18 519472 52 42101793
Mass 37.73 12.22 208 519282 8531 42093314
Mantle cell lymphoma recurrent 37.62 12.22 54 519436 969 42100876
Body temperature fluctuation 37.51 12.22 70 519420 1577 42100268
Osteomyelitis 37.45 12.22 363 519127 17860 42083985
Graft versus host disease in skin 37.38 12.22 144 519346 5068 42096777
Necrotising retinitis 37.34 12.22 54 519436 976 42100869
Nasopharyngitis 37.30 12.22 1312 518178 82684 42019161
Endophthalmitis 37.30 12.22 129 519361 4304 42097541
Hydronephrosis 37.14 12.22 260 519230 11605 42090240
Mental impairment 36.97 12.22 58 519432 12259 42089586
Transplant failure 36.96 12.22 121 519369 3923 42097922
Atrial fibrillation 36.92 12.22 1360 518130 138233 41963612
Psychomotor skills impaired 36.86 12.22 9 519481 5195 42096650
Acute myeloid leukaemia 36.66 12.22 424 519066 21832 42080013
Meningitis listeria 36.50 12.22 43 519447 629 42101216
Sudden death 36.47 12.22 94 519396 16535 42085310
Pericarditis fungal 36.44 12.22 27 519463 208 42101637
Plasma cell myeloma 36.42 12.22 387 519103 47191 42054654
Inflammatory bowel disease 36.31 12.22 110 519380 3419 42098426
Renal tubular injury 36.10 12.22 72 519418 1707 42100138
Blood cholesterol 35.93 12.22 27 519463 213 42101632
Blood immunoglobulin G decreased 35.88 12.22 84 519406 2230 42099615
Cardiomegaly 35.84 12.22 96 519394 16670 42085175
Myalgia 35.79 12.22 894 518596 95186 42006659
Prostate cancer metastatic 35.78 12.22 168 519322 6461 42095384
Chromoblastomycosis 35.62 12.22 21 519469 104 42101741
Euphoric mood 35.62 12.22 17 519473 6436 42095409
Bradyphrenia 35.56 12.22 10 519480 5252 42096593
Meningitis enterococcal 35.44 12.22 23 519467 139 42101706
Behaviour disorder 35.38 12.22 21 519469 7033 42094812
Malacoplakia gastrointestinal 35.37 12.22 24 519466 158 42101687
Tendon rupture 35.31 12.22 193 519297 7890 42093955
Solar lentigo 35.15 12.22 41 519449 593 42101252
Plasmablastic lymphoma 35.10 12.22 41 519449 594 42101251
Oropharyngeal pain 35.07 12.22 720 518770 41790 42060055
Hyperlipidaemia 35.02 12.22 139 519351 21377 42080468
Wrong product administered 34.98 12.22 16 519474 6210 42095635
Corynebacterium infection 34.53 12.22 48 519442 835 42101010
Pulmonary fibrosis 34.48 12.22 486 519004 26195 42075650
Troponin increased 34.40 12.22 118 519372 18944 42082901
Skin squamous cell carcinoma recurrent 34.40 12.22 20 519470 96 42101749
Lip swelling 34.35 12.22 118 519372 18935 42082910
Blood urea increased 34.32 12.22 246 519244 32547 42069298
Nodule 34.30 12.22 266 519224 12268 42089577
Vasculitis 34.23 12.22 359 519131 18035 42083810
Upper-airway cough syndrome 34.12 12.22 124 519366 4242 42097603
Unevaluable event 34.07 12.22 261 519229 34027 42067818
Blood cholesterol increased 33.96 12.22 189 519301 26552 42075293
Lymphoproliferative disorder 33.95 12.22 103 519387 3204 42098641
Angina pectoris 33.83 12.22 248 519242 32648 42069197
Mycobacterium abscessus infection 33.82 12.22 44 519446 716 42101129
Blood immunoglobulin M decreased 33.75 12.22 47 519443 819 42101026
Exposure to SARS-CoV-2 33.70 12.22 39 519451 559 42101286
Stomatitis 33.61 12.22 422 519068 49907 42051938
Lung hyperinflation 33.52 12.22 54 519436 1077 42100768
Apparent mineralocorticoid excess 33.39 12.22 17 519473 59 42101786
Breath sounds abnormal 33.29 12.22 257 519233 11836 42090009
Exposure during pregnancy 33.25 12.22 33 519457 8515 42093330
Enterobacter infection 33.15 12.22 96 519394 2908 42098937
Cryptococcal fungaemia 33.13 12.22 23 519467 158 42101687
Ventricular extrasystoles 33.12 12.22 71 519419 13319 42088526
Hypothermia 32.96 12.22 64 519426 12451 42089394
Exposure to toxic agent 32.91 12.22 10 519480 4994 42096851
T-cell lymphoma 32.75 12.22 54 519436 1099 42100746
Nasal obstruction 32.73 12.22 50 519440 951 42100894
Skin squamous cell carcinoma metastatic 32.72 12.22 18 519472 76 42101769
Epstein-Barr virus test positive 32.65 12.22 41 519449 643 42101202
Scleroderma 32.58 12.22 69 519421 1709 42100136
Fear 32.57 12.22 52 519438 10913 42090932
Respiratory disorder 32.56 12.22 412 519078 21673 42080172
Hyperglycaemia 32.51 12.22 760 518730 45099 42056746
Ataxia 32.49 12.22 95 519395 16030 42085815
Blood calcium increased 32.47 12.22 33 519457 8421 42093424
Papilloma viral infection 32.44 12.22 42 519448 680 42101165
Clear cell renal cell carcinoma 32.43 12.22 57 519433 1224 42100621
Tendon disorder 32.42 12.22 103 519387 3286 42098559
Pemphigus 32.40 12.22 74 519416 1932 42099913
Cutaneous sporotrichosis 32.29 12.22 15 519475 40 42101805
Blood pressure diastolic abnormal 32.13 12.22 154 519336 5974 42095871
Rash maculo-papular 32.07 12.22 297 519193 37206 42064639
Obliterative bronchiolitis 31.92 12.22 61 519429 1400 42100445
Lung disorder 31.79 12.22 787 518703 47136 42054709
Trench fever 31.78 12.22 15 519475 42 42101803
Upper respiratory fungal infection 31.69 12.22 23 519467 171 42101674
Drug screen positive 31.59 12.22 6 519484 4125 42097720
Neuroendocrine carcinoma of the skin 31.57 12.22 48 519442 909 42100936
Eosinophil count increased 31.47 12.22 232 519258 10531 42091314
Polymyalgia rheumatica 31.41 12.22 80 519410 2243 42099602
Influenza 31.40 12.22 986 518504 61189 42040656
Bronchial secretion retention 31.37 12.22 64 519426 1543 42100302
Vital capacity decreased 31.31 12.22 35 519455 482 42101363
Blood potassium increased 31.29 12.22 118 519372 18418 42083427
Gastroenteritis cryptosporidial 31.29 12.22 26 519464 241 42101604
Lipodystrophy acquired 31.13 12.22 3 519487 3447 42098398
Dementia 31.13 12.22 100 519390 16380 42085465
Tuberculosis of genitourinary system 31.05 12.22 17 519473 71 42101774
Blood pressure decreased 30.92 12.22 512 518978 57820 42044025
Choroiditis 30.77 12.22 58 519432 1317 42100528
Blood creatinine increased 30.61 12.22 1065 518425 108938 41992907
Type 2 lepra reaction 30.50 12.22 29 519461 326 42101519
Apnoea 30.50 12.22 30 519460 7773 42094072
Abdominal distension 30.49 12.22 654 518836 71081 42030764
Pneumonia klebsiella 30.46 12.22 117 519373 4112 42097733
Depressed mood 30.39 12.22 164 519326 23220 42078625
Atrial septal defect 30.32 12.22 31 519459 7888 42093957
Immunosuppressant drug level decreased 30.26 12.22 68 519422 1756 42100089
Product use issue 30.25 12.22 1183 518307 75568 42026277
Symptom masked 30.22 12.22 45 519445 836 42101009
Wrong patient received product 30.11 12.22 4 519486 3579 42098266
Restrictive pulmonary disease 29.89 12.22 57 519433 1306 42100539
Hypokalaemia 29.87 12.22 656 518834 71065 42030780
Immune reconstitution inflammatory syndrome 29.86 12.22 219 519271 9924 42091921
Bacterial pyelonephritis 29.85 12.22 28 519462 309 42101536
Infusion related reaction 29.84 12.22 961 518529 59845 42042000
Atypical mycobacterial infection 29.80 12.22 57 519433 1309 42100536
Renal impairment 29.79 12.22 1071 518419 109157 41992688
Electrocardiogram QRS complex prolonged 29.68 12.22 17 519473 5806 42096039
Dysgeusia 29.56 12.22 270 519220 33919 42067926
Hypernatraemia 29.40 12.22 48 519442 9984 42091861
Ill-defined disorder 29.37 12.22 316 519174 15980 42085865
Dysplastic naevus 29.33 12.22 39 519451 649 42101196
Torsade de pointes 29.25 12.22 37 519453 8557 42093288
Lactobacillus infection 29.22 12.22 29 519461 345 42101500
Malignant melanoma in situ 29.17 12.22 87 519403 2680 42099165
Presyncope 29.10 12.22 157 519333 22230 42079615
Aphasia 29.08 12.22 173 519317 23910 42077935
Chronic graft versus host disease in skin 29.06 12.22 62 519428 1544 42100301
Ventricular remodelling 29.02 12.22 17 519473 83 42101762
Periostitis 28.88 12.22 28 519462 323 42101522
On and off phenomenon 28.83 12.22 4 519486 3463 42098382
Microsporidia infection 28.82 12.22 51 519439 1101 42100744
Bronchial hyperreactivity 28.80 12.22 69 519421 1860 42099985
Metastatic squamous cell carcinoma 28.73 12.22 38 519452 629 42101216
Myasthenia gravis crisis 28.71 12.22 43 519447 803 42101042
Cytopenia 28.67 12.22 333 519157 17164 42084681
Cytomegalovirus gastrointestinal infection 28.61 12.22 28 519462 327 42101518
Ventricular septal defect 28.56 12.22 9 519481 4390 42097455
Anxiety 28.52 12.22 1168 518322 117392 41984453
Secondary immunodeficiency 28.33 12.22 43 519447 813 42101032
Glomerulonephritis 28.32 12.22 82 519408 2484 42099361
Granulocytopenia 28.21 12.22 27 519463 7087 42094758
Hepatic encephalopathy 28.19 12.22 104 519386 16338 42085507
Disseminated aspergillosis 28.15 12.22 64 519426 1666 42100179
Eosinophilic bronchitis 28.08 12.22 24 519466 232 42101613
Chondropathy 27.97 12.22 52 519438 1168 42100677
Aspergilloma 27.90 12.22 31 519459 424 42101421
Cytology abnormal 27.83 12.22 29 519461 367 42101478
Photodermatosis 27.78 12.22 40 519450 720 42101125
Bronchial disorder 27.67 12.22 56 519434 1342 42100503
Prescribed underdose 27.59 12.22 52 519438 10230 42091615
Yersinia infection 27.51 12.22 15 519475 62 42101783
Infectious thyroiditis 27.45 12.22 18 519472 111 42101734
Sarcoidosis 27.45 12.22 103 519387 3579 42098266
Pancreas transplant rejection 27.43 12.22 22 519468 193 42101652
Cholestasis 27.42 12.22 262 519228 32617 42069228
Aortic stenosis 27.39 12.22 40 519450 8705 42093140
Granulomatous dermatitis 27.29 12.22 26 519464 293 42101552
Cold sweat 27.26 12.22 61 519429 11269 42090576
Drug hypersensitivity 27.24 12.22 964 518526 98425 42003420
Cyanosis 27.16 12.22 93 519397 14938 42086907
Sinusitis bacterial 27.04 12.22 34 519456 534 42101311
Tachypnoea 27.02 12.22 154 519336 21508 42080337
Lung consolidation 26.90 12.22 156 519334 6521 42095324
Blood glucose increased 26.84 12.22 688 518802 73011 42028834
Donor specific antibody present 26.80 12.22 20 519470 156 42101689
Ketoacidosis 26.75 12.22 16 519474 5336 42096509
Red blood cell sedimentation rate abnormal 26.71 12.22 105 519385 3731 42098114
Acne 26.68 12.22 269 519221 13375 42088470
Hypocalcaemia 26.65 12.22 237 519253 29936 42071909
Hepatitis viral 26.53 12.22 41 519449 788 42101057
Acute pulmonary histoplasmosis 26.48 12.22 21 519469 181 42101664
Tuberculosis of central nervous system 26.47 12.22 22 519468 204 42101641
Central nervous system abscess 26.44 12.22 13 519477 41 42101804
Mycotic allergy 26.44 12.22 124 519366 4767 42097078
Vascular stent thrombosis 26.36 12.22 4 519486 3238 42098607
Diabetes mellitus 26.29 12.22 937 518553 59150 42042695
Faeces soft 26.16 12.22 124 519366 4788 42097057
Opportunistic infection 26.12 12.22 68 519422 1933 42099912
Intestinal perforation 26.10 12.22 224 519266 10650 42091195
Viral infection 26.10 12.22 402 519088 22081 42079764
Somnambulism 26.03 12.22 5 519485 3410 42098435
Human herpes virus 8 test positive 25.83 12.22 12 519478 32 42101813
Salmonellosis 25.70 12.22 52 519438 1246 42100599
Toxoplasmosis 25.65 12.22 59 519431 1548 42100297
Lupus nephritis 25.62 12.22 32 519458 499 42101346
Shock 25.60 12.22 229 519261 28892 42072953
Chromaturia 25.58 12.22 104 519386 15885 42085960
Device difficult to use 25.53 12.22 12 519478 4584 42097261
Blood pressure systolic abnormal 25.51 12.22 134 519356 5394 42096451
Thrombotic microangiopathy 25.42 12.22 284 519206 14498 42087347
Malignant transformation 25.38 12.22 44 519446 934 42100911
Cardiac failure chronic 25.37 12.22 49 519441 9552 42092293
Allergic fungal rhinosinusitis 25.35 12.22 13 519477 46 42101799
Primary effusion lymphoma 25.32 12.22 12 519478 34 42101811
Spirometry abnormal 25.32 12.22 127 519363 5019 42096826
Middle insomnia 25.32 12.22 173 519317 7660 42094185
Atrioventricular block first degree 25.32 12.22 25 519465 6466 42095379
Kidney infection 25.24 12.22 155 519335 6615 42095230
Psychomotor retardation 25.20 12.22 11 519479 4388 42097457
Infectious pleural effusion 25.18 12.22 91 519399 3104 42098741
Terminal ileitis 25.12 12.22 34 519456 576 42101269
Nasal oedema 25.07 12.22 26 519464 327 42101518
Kaposi's sarcoma 25.00 12.22 39 519451 756 42101089
Lymphadenopathy mediastinal 24.92 12.22 91 519399 3120 42098725
Abdominal wall abscess 24.92 12.22 36 519454 650 42101195
Q fever 24.89 12.22 18 519472 133 42101712
Capnocytophaga infection 24.89 12.22 18 519472 133 42101712
Campylobacter infection 24.88 12.22 54 519436 1361 42100484
Encephalitis 24.86 12.22 194 519296 8964 42092881
Blood thyroid stimulating hormone increased 24.84 12.22 17 519473 5275 42096570
Peripheral arterial occlusive disease 24.81 12.22 28 519462 6810 42095035
Cholangitis 24.80 12.22 59 519431 10668 42091177
Disseminated varicella zoster vaccine virus infection 24.77 12.22 14 519476 63 42101782
Hyperlactacidaemia 24.77 12.22 12 519478 4504 42097341
Immunodeficiency 24.76 12.22 163 519327 7127 42094718
Gynaecomastia 24.62 12.22 75 519415 12492 42089353
Ammonia increased 24.62 12.22 13 519477 4646 42097199
Antineutrophil cytoplasmic antibody positive 24.58 12.22 112 519378 4253 42097592
Endocarditis bacterial 24.57 12.22 50 519440 1203 42100642
Complications of transplanted heart 24.57 12.22 25 519465 307 42101538
Pneumonia legionella 24.57 12.22 72 519418 2196 42099649
Electrolyte imbalance 24.46 12.22 116 519374 16985 42084860
Prothrombin time prolonged 24.44 12.22 49 519441 9420 42092425
Renal vein thrombosis 24.30 12.22 30 519460 462 42101383
Nipple swelling 24.26 12.22 27 519463 370 42101475
Pain 24.18 12.22 3371 516119 241477 41860368
Systemic mycosis 24.18 12.22 74 519416 2313 42099532
Tumour lysis syndrome 24.11 12.22 393 519097 21838 42080007
Ankylosing spondylitis 24.11 12.22 158 519332 6898 42094947
Renal failure 24.07 12.22 1470 518020 142256 41959589
Synovitis 24.07 12.22 293 519197 15274 42086571
Ileal ulcer 23.89 12.22 42 519448 902 42100943
Underdose 23.87 12.22 113 519377 16553 42085292
Blood potassium decreased 23.79 12.22 148 519342 20236 42081609
Diabetic ketoacidosis 23.79 12.22 167 519323 22200 42079645
Diabetic cardiomyopathy 23.78 12.22 10 519480 19 42101826
Erythema multiforme 23.77 12.22 54 519436 9923 42091922
Necrotising fasciitis fungal 23.77 12.22 11 519479 29 42101816
Nocardia sepsis 23.77 12.22 11 519479 29 42101816
Angiocentric lymphoma 23.76 12.22 31 519459 506 42101339
Coma scale abnormal 23.74 12.22 13 519477 4552 42097293
Granuloma 23.74 12.22 105 519385 3936 42097909
Neuropathy peripheral 23.73 12.22 1007 518483 100846 42000999
Emotional distress 23.71 12.22 108 519382 15985 42085860
Gait disturbance 23.66 12.22 965 518525 97035 42004810
Diarrhoea haemorrhagic 23.61 12.22 168 519322 7539 42094306
Hypertonia 23.56 12.22 16 519474 4985 42096860
Tracheal stenosis 23.51 12.22 24 519466 296 42101549
Red blood cell count decreased 23.49 12.22 270 519220 32445 42069400
Social avoidant behaviour 23.47 12.22 6 519484 3358 42098487
Synovial cyst 23.44 12.22 78 519412 2551 42099294
Terminal insomnia 23.40 12.22 41 519449 878 42100967
Glycosylated haemoglobin increased 23.33 12.22 80 519410 12844 42089001
B-cell lymphoma 23.30 12.22 120 519370 4793 42097052
Graft versus host disease in gastrointestinal tract 23.28 12.22 124 519366 5019 42096826
Penicillium infection 23.26 12.22 24 519466 300 42101545
Blood sodium decreased 23.26 12.22 128 519362 18034 42083811
Carotid artery occlusion 23.22 12.22 11 519479 4183 42097662
Alveolar proteinosis 23.22 12.22 36 519454 694 42101151
Injury 23.06 12.22 168 519322 22148 42079697
Prescription drug used without a prescription 23.06 12.22 3 519487 2727 42099118
Vocal cord dysfunction 23.03 12.22 20 519470 198 42101647
Disseminated Bacillus Calmette-Guerin infection 23.02 12.22 23 519467 276 42101569
Tearfulness 23.01 12.22 7 519483 3493 42098352
Orbital apex syndrome 23.01 12.22 11 519479 32 42101813
Orchitis 23.00 12.22 70 519420 2181 42099664
Central nervous system fungal infection 22.98 12.22 28 519462 425 42101420
Herpes zoster cutaneous disseminated 22.95 12.22 20 519470 199 42101646
Sedation complication 22.84 12.22 4 519486 2915 42098930
Physical disability 22.78 12.22 62 519428 1811 42100034
Intracranial pressure increased 22.75 12.22 115 519375 4559 42097286
Obstructive nephropathy 22.69 12.22 12 519478 46 42101799
Retinitis 22.66 12.22 29 519461 464 42101381
Bacillus infection 22.63 12.22 36 519454 710 42101135
Subarachnoid haemorrhage 22.61 12.22 95 519395 14377 42087468
Cell-mediated immune deficiency 22.61 12.22 14 519476 77 42101768
Metastatic malignant melanoma 22.59 12.22 72 519418 2301 42099544
Ileal stenosis 22.55 12.22 62 519428 1822 42100023
Skin graft rejection 22.53 12.22 11 519479 34 42101811
Organising pneumonia 22.39 12.22 163 519327 7369 42094476
Trichosporon infection 22.36 12.22 41 519449 911 42100934
Soft tissue infection 22.34 12.22 78 519412 2615 42099230
Erythema nodosum 22.30 12.22 61 519429 1787 42100058
Abscess intestinal 22.18 12.22 60 519430 1746 42100099
Lymph node calcification 22.14 12.22 17 519473 139 42101706
Haemorrhage intracranial 22.11 12.22 121 519369 17071 42084774
Cutaneous blastomycosis 22.08 12.22 11 519479 36 42101809
Transitional cell carcinoma 22.06 12.22 77 519413 2581 42099264
Acinetobacter infection 22.04 12.22 54 519436 1477 42100368
Neuralgia 21.97 12.22 203 519287 25444 42076401
Viraemia 21.93 12.22 59 519431 1711 42100134
Conjunctivitis allergic 21.83 12.22 135 519355 5776 42096069
Pulmonary tuberculosis 21.82 12.22 128 519362 5373 42096472
Eye abscess 21.82 12.22 18 519472 165 42101680
Abdominal infection 21.80 12.22 74 519416 2445 42099400
Pneumatosis intestinalis 21.80 12.22 115 519375 4637 42097208
Acute generalised exanthematous pustulosis 21.74 12.22 45 519445 8550 42093295
Mite allergy 21.72 12.22 120 519370 4926 42096919
Infection in an immunocompromised host 21.71 12.22 43 519447 1014 42100831
Escherichia urinary tract infection 21.70 12.22 108 519382 4255 42097590
Meningitis candida 21.67 12.22 17 519473 144 42101701
Zoonotic bacterial infection 21.65 12.22 13 519477 67 42101778
Bacteraemia 21.61 12.22 427 519063 24613 42077232
Rectal tenesmus 21.56 12.22 45 519445 1103 42100742
Abscess limb 21.51 12.22 103 519387 3994 42097851
Homicidal ideation 21.49 12.22 4 519486 2790 42099055
Drug dose omission by device 21.46 12.22 24 519466 5862 42095983
Histoplasmosis cutaneous 21.43 12.22 11 519479 39 42101806
Sleep disorder due to general medical condition, insomnia type 21.35 12.22 52 519438 1417 42100428
Faecaloma 21.33 12.22 27 519463 6243 42095602
Graft infection 21.33 12.22 27 519463 427 42101418
Pulmonary alveolar haemorrhage 21.25 12.22 275 519215 14541 42087304
Mycetoma mycotic 21.22 12.22 24 519466 335 42101510
Cytomegalovirus nephritis 21.22 12.22 16 519474 127 42101718
Endocarditis 21.20 12.22 171 519319 7981 42093864
Faecal calprotectin abnormal 21.18 12.22 23 519467 306 42101539
Retroperitoneal lymphadenopathy 21.16 12.22 42 519448 992 42100853
Thirst 21.14 12.22 50 519440 9058 42092787
Petit mal epilepsy 21.11 12.22 9 519481 3641 42098204
Drug tolerance decreased 21.02 12.22 70 519420 2290 42099555
Neutrophilic dermatosis 20.96 12.22 23 519467 310 42101535
Acquired haemophilia 20.92 12.22 56 519434 1619 42100226
Pleural thickening 20.92 12.22 28 519462 469 42101376
Dermatitis acneiform 20.89 12.22 39 519451 7700 42094145
Chronic kidney disease 20.86 12.22 428 519062 46813 42055032
Mobility decreased 20.85 12.22 571 518919 34735 42067110
Sleep terror 20.84 12.22 5 519485 2921 42098924
Coagulation factor deficiency 20.76 12.22 21 519469 256 42101589
Mouth ulceration 20.74 12.22 276 519214 14687 42087158
Device occlusion 20.74 12.22 45 519445 8405 42093440
Malignant melanoma 20.68 12.22 190 519300 9210 42092635
Sinus tachycardia 20.62 12.22 157 519333 20496 42081349
Panniculitis 20.60 12.22 66 519424 2115 42099730
Atrioventricular block 20.59 12.22 55 519435 9560 42092285
Norovirus infection 20.55 12.22 35 519455 732 42101113
Myasthenia gravis 20.52 12.22 114 519376 16023 42085822
Lower respiratory tract congestion 20.50 12.22 54 519436 1546 42100299
Giant cell myocarditis 20.49 12.22 9 519481 20 42101825
Depression suicidal 20.43 12.22 7 519483 3238 42098607
Fungaemia 20.37 12.22 84 519406 3052 42098793
Dislocation of vertebra 20.36 12.22 26 519464 415 42101430
Eosinophil count 20.35 12.22 18 519472 183 42101662
Haematocrit decreased 20.32 12.22 301 519189 34607 42067238
Iron deficiency 20.28 12.22 68 519422 10993 42090852
Postoperative thoracic procedure complication 20.26 12.22 11 519479 45 42101800
Large intestinal ulcer 20.14 12.22 71 519419 2392 42099453
Spinal cord abscess 20.13 12.22 26 519464 420 42101425
Complications of transplant surgery 20.10 12.22 28 519462 488 42101357
Hyperthyroidism 20.09 12.22 98 519392 14243 42087602
Ileostomy 20.04 12.22 43 519447 1075 42100770
Polyp 20.04 12.22 110 519380 4504 42097341
Anger 20.00 12.22 86 519404 12932 42088913
Arteriospasm coronary 19.96 12.22 17 519473 4721 42097124
Vasogenic cerebral oedema 19.91 12.22 41 519449 995 42100850
Unintentional medical device removal 19.89 12.22 7 519483 3184 42098661
Diverticulitis 19.87 12.22 389 519101 22384 42079461
Meningoencephalitis amoebic 19.82 12.22 19 519471 216 42101629
C-reactive protein abnormal 19.78 12.22 186 519304 9075 42092770
Coordination abnormal 19.65 12.22 43 519447 8007 42093838
Glomerulonephritis proliferative 19.63 12.22 20 519470 246 42101599
Transient ischaemic attack 19.61 12.22 291 519199 33448 42068397
Logorrhoea 19.60 12.22 5 519485 2802 42099043
Parathyroid gland enlargement 19.60 12.22 17 519473 168 42101677
Feeling abnormal 19.55 12.22 675 518815 69111 42032734
Urinoma 19.51 12.22 20 519470 248 42101597
Right ventricular hypertrophy 19.50 12.22 52 519438 1500 42100345
Hypovolaemia 19.46 12.22 73 519417 11412 42090433
Biliary hamartoma 19.43 12.22 8 519482 14 42101831
Device adhesion issue 19.41 12.22 10 519480 3624 42098221
Proctitis 19.39 12.22 79 519411 2854 42098991
Hepatic artery aneurysm 19.38 12.22 11 519479 50 42101795
Face oedema 19.37 12.22 93 519397 13573 42088272
Optic neuropathy 19.34 12.22 71 519419 2441 42099404
Blood lactate dehydrogenase increased 19.34 12.22 435 519055 25646 42076199
Gastric cancer 19.33 12.22 34 519456 6869 42094976
Lung abscess 19.33 12.22 85 519405 3178 42098667
Psoriatic arthropathy 19.33 12.22 419 519071 24548 42077297
Neurotoxicity 19.31 12.22 400 519090 23251 42078594
Wrist deformity 19.29 12.22 23 519467 341 42101504
Urinary incontinence 19.22 12.22 170 519320 21498 42080347
Haemolysis 19.20 12.22 190 519300 9399 42092446
Gastroenteritis listeria 19.17 12.22 7 519483 7 42101838
Eye infection syphilitic 19.17 12.22 7 519483 7 42101838
Ophthalmic herpes zoster 19.11 12.22 42 519448 1068 42100777
Therapeutic product effect variable 19.07 12.22 7 519483 3102 42098743
Bacillus bacteraemia 19.05 12.22 17 519473 175 42101670
Joint lock 19.04 12.22 48 519442 1337 42100508
Hepatosplenic T-cell lymphoma 19.04 12.22 27 519463 479 42101366
Drug dependence 19.03 12.22 245 519245 28849 42072996
Sinus congestion 19.02 12.22 148 519342 6832 42095013
Alcohol abuse 19.01 12.22 13 519477 4036 42097809
HCoV-HKU1 infection 18.97 12.22 10 519480 38 42101807
Chorioretinopathy 18.94 12.22 51 519439 1480 42100365
Cutaneous malacoplakia 18.94 12.22 15 519475 129 42101716
Heparin-induced thrombocytopenia 18.93 12.22 32 519458 6565 42095280
Post-acute COVID-19 syndrome 18.89 12.22 25 519465 414 42101431
Orf 18.87 12.22 9 519481 26 42101819
Drug resistance 18.86 12.22 549 518941 33699 42068146
Asthenia 18.82 12.22 3071 516419 277722 41824123
Decubitus ulcer 18.81 12.22 65 519425 10412 42091433
Skin exfoliation 18.78 12.22 375 519115 41178 42060667
Herpes oesophagitis 18.70 12.22 16 519474 155 42101690
Loss of libido 18.69 12.22 7 519483 3063 42098782
Pancreatitis acute 18.65 12.22 292 519198 33272 42068573
Scleritis 18.65 12.22 34 519456 752 42101093
Angiosarcoma metastatic 18.64 12.22 13 519477 90 42101755
Drooling 18.64 12.22 15 519475 4284 42097561
Nystagmus 18.61 12.22 23 519467 5373 42096472
Angina unstable 18.60 12.22 74 519416 11374 42090471
Lymphocele 18.60 12.22 51 519439 1496 42100349
Fluoride increased 18.58 12.22 11 519479 55 42101790
Chest discomfort 18.57 12.22 951 518539 62665 42039180
Cardiac perforation 18.56 12.22 12 519478 72 42101773
Device issue 18.53 12.22 93 519397 13416 42088429
Dialysis 18.53 12.22 79 519411 11907 42089938
Mediastinitis 18.51 12.22 40 519450 1005 42100840
Immune-mediated hepatic disorder 18.50 12.22 4 519486 2510 42099335
Cutaneous T-cell lymphoma 18.46 12.22 60 519430 1938 42099907
Drug abuser 18.44 12.22 10 519480 3521 42098324
Oral herpes 18.42 12.22 156 519334 7388 42094457
Myoglobin blood increased 18.41 12.22 11 519479 3671 42098174
Pleomorphic malignant fibrous histiocytoma 18.39 12.22 9 519481 28 42101817
Drug level fluctuating 18.38 12.22 31 519459 643 42101202
Anal fissure 18.32 12.22 118 519372 5121 42096724
Blood prolactin increased 18.31 12.22 3 519487 2295 42099550
Metapneumovirus pneumonia 18.30 12.22 12 519478 74 42101771
Nasal disorder 18.26 12.22 60 519430 1949 42099896
Osteomyelitis acute 18.20 12.22 20 519470 270 42101575
Rhinorrhoea 18.16 12.22 512 518978 31282 42070563
Odynophagia 18.15 12.22 143 519347 6627 42095218
Demodicidosis 18.14 12.22 18 519472 214 42101631
Systemic infection 18.14 12.22 22 519468 5183 42096662
Post transplant distal limb syndrome 18.11 12.22 25 519465 432 42101413
Skin striae 18.10 12.22 33 519457 730 42101115
Splenic lesion 18.05 12.22 22 519468 334 42101511
Herpes dermatitis 18.05 12.22 15 519475 139 42101706
Hypoaesthesia 18.04 12.22 700 518790 70763 42031082
Escherichia sepsis 18.03 12.22 126 519364 5621 42096224
Flushing 18.02 12.22 330 519160 36698 42065147
Gingival hypertrophy 17.99 12.22 68 519422 2371 42099474
Emphysema 17.97 12.22 222 519268 11613 42090232
Dysmorphism 17.90 12.22 9 519481 3307 42098538
Sudden cardiac death 17.89 12.22 13 519477 3911 42097934
Needle issue 17.88 12.22 51 519439 8676 42093169
Jaundice 17.87 12.22 305 519185 34284 42067561
Hand deformity 17.85 12.22 92 519398 3676 42098169
Pseudomonal bacteraemia 17.84 12.22 67 519423 2329 42099516
Streptococcal endocarditis 17.83 12.22 11 519479 60 42101785
Marginal zone lymphoma recurrent 17.83 12.22 11 519479 60 42101785
Cholelithiasis 17.82 12.22 190 519300 23156 42078689
Erythema 17.80 12.22 1115 518375 107678 41994167
Bartonellosis 17.73 12.22 9 519481 31 42101814
Cardiac pseudoaneurysm 17.73 12.22 9 519481 31 42101814
Cardiac infection 17.72 12.22 19 519471 249 42101596
Neuromyelitis optica spectrum disorder 17.72 12.22 19 519471 249 42101596
Gastric haemorrhage 17.71 12.22 67 519423 10448 42091397
Colostomy 17.70 12.22 29 519461 587 42101258
Anhedonia 17.68 12.22 42 519448 7598 42094247
Affect lability 17.67 12.22 14 519476 4030 42097815
Anal fistula 17.64 12.22 133 519357 6080 42095765
Coagulation factor V level abnormal 17.63 12.22 15 519475 144 42101701
Mitochondrial toxicity 17.61 12.22 5 519485 2610 42099235
Epstein-Barr virus infection reactivation 17.56 12.22 71 519419 2556 42099289
Abdominal pain upper 17.55 12.22 825 518665 81784 42020061
Clostridium difficile colitis 17.54 12.22 360 519130 20892 42080953
Bone density decreased 17.53 12.22 63 519427 2143 42099702
Diaphragmatic hernia 17.53 12.22 21 519469 313 42101532
Viral vasculitis 17.46 12.22 13 519477 101 42101744
Acute hepatitis C 17.44 12.22 14 519476 123 42101722
Urinary tract infection bacterial 17.42 12.22 66 519424 2304 42099541
Atypical mycobacterial pneumonia 17.38 12.22 18 519472 226 42101619
Intestinal stenosis 17.35 12.22 74 519416 2730 42099115
Hypertrophic cardiomyopathy 17.32 12.22 48 519442 1417 42100428
Drug intolerance 17.32 12.22 1170 518320 79254 42022591
Emphysematous pyelonephritis 17.31 12.22 16 519474 173 42101672
Eccrine carcinoma 17.31 12.22 8 519482 21 42101824
Hidradenocarcinoma 17.31 12.22 8 519482 21 42101824
Biphasic mesothelioma 17.28 12.22 11 519479 64 42101781
Sebaceous carcinoma 17.22 12.22 12 519478 83 42101762
Hypertensive crisis 17.21 12.22 65 519425 10141 42091704
Enuresis 17.18 12.22 6 519484 2742 42099103
Acarodermatitis 17.14 12.22 32 519458 721 42101124
Oxalosis 17.11 12.22 9 519481 34 42101811
Application site erythema 17.11 12.22 5 519485 2561 42099284
Rheumatoid lung 17.10 12.22 36 519454 888 42100957
Diaphragm muscle weakness 17.07 12.22 15 519475 151 42101694
Mineral metabolism disorder 17.07 12.22 23 519467 388 42101457
Throat irritation 17.06 12.22 238 519252 12798 42089047
Hepatic cancer 17.05 12.22 50 519440 8430 42093415
Malignant neoplasm progression 17.05 12.22 1115 518375 107285 41994560
Post procedural discharge 17.03 12.22 21 519469 323 42101522
Anal stenosis 16.98 12.22 21 519469 324 42101521
Rheumatoid nodule 16.98 12.22 77 519413 2918 42098927
Anal abscess 16.93 12.22 158 519332 7692 42094153
Kounis syndrome 16.93 12.22 10 519480 3358 42098487
Graft versus host disease 16.93 12.22 236 519254 12689 42089156
Candida osteomyelitis 16.92 12.22 9 519481 35 42101810
Escherichia pyelonephritis 16.91 12.22 14 519476 129 42101716
Prophylaxis against transplant rejection 16.89 12.22 10 519480 50 42101795
Inadequate analgesia 16.78 12.22 9 519481 3188 42098657
Subdural haemorrhage 16.76 12.22 11 519479 3490 42098355
Graft complication 16.71 12.22 31 519459 695 42101150
Supraventricular tachycardia 16.69 12.22 86 519404 12322 42089523
Ileectomy 16.69 12.22 15 519475 156 42101689
Pasteurella infection 16.67 12.22 13 519477 109 42101736
Forced vital capacity decreased 16.67 12.22 36 519454 904 42100941
Neurosarcoidosis 16.63 12.22 17 519473 210 42101635
Lepromatous leprosy 16.63 12.22 11 519479 69 42101776
Fat embolism syndrome 16.63 12.22 11 519479 69 42101776
Subacute endocarditis 16.63 12.22 11 519479 69 42101776
Hepatic fibrosis 16.59 12.22 109 519381 4763 42097082
T-cell prolymphocytic leukaemia 16.58 12.22 10 519480 52 42101793
Taste disorder 16.57 12.22 66 519424 10141 42091704
SARS-CoV-2 viraemia 16.56 12.22 12 519478 89 42101756
Graft ischaemia 16.54 12.22 9 519481 37 42101808
Ankle deformity 16.51 12.22 17 519473 212 42101633
Atrioventricular block second degree 16.48 12.22 16 519474 4171 42097674
Enteritis 16.47 12.22 203 519287 10613 42091232
Neuritis 16.46 12.22 131 519359 6089 42095756
Vertigo 16.43 12.22 307 519183 34040 42067805
Adrenal insufficiency 16.43 12.22 323 519167 18601 42083244
Large intestinal stenosis 16.41 12.22 57 519433 1906 42099939
Exposure via ingestion 16.40 12.22 3 519487 2119 42099726
Colectomy total 16.36 12.22 21 519469 337 42101508
Gastrooesophageal reflux disease 16.35 12.22 688 518802 44335 42057510
Hot flush 16.32 12.22 372 519118 21979 42079866
Forced expiratory volume 16.30 12.22 13 519477 113 42101732
Myocarditis infectious 16.29 12.22 10 519480 54 42101791
Disability 16.28 12.22 126 519364 5807 42096038
Aeromonas infection 16.27 12.22 21 519469 339 42101506
Product storage error 16.27 12.22 75 519415 11065 42090780
Morganella infection 16.26 12.22 28 519462 591 42101254
Disorder of orbit 16.24 12.22 12 519478 92 42101753
Anaplastic large cell lymphoma T- and null-cell types 16.17 12.22 14 519476 138 42101707
Chronic papillomatous dermatitis 16.15 12.22 10 519480 55 42101790
Osteomyelitis blastomyces 16.10 12.22 7 519483 15 42101830
Meningitis histoplasma 16.10 12.22 7 519483 15 42101830
Inspiratory capacity decreased 16.10 12.22 8 519482 2959 42098886
Musculoskeletal disorder 16.07 12.22 137 519353 6501 42095344
Herpes virus infection 16.02 12.22 88 519402 3604 42098241
Depressive symptom 16.02 12.22 14 519476 3839 42098006
Blood stem cell transplant failure 16.00 12.22 24 519466 449 42101396
Infective uveitis 15.96 12.22 6 519484 7 42101838
Bradykinesia 15.94 12.22 26 519464 5410 42096435
Rheumatoid factor negative 15.93 12.22 37 519453 977 42100868
Maternal drugs affecting foetus 15.90 12.22 14 519476 3825 42098020
Eczema 15.90 12.22 306 519184 33780 42068065
Sputum purulent 15.89 12.22 30 519460 682 42101163
Hip arthroplasty 15.88 12.22 115 519375 5190 42096655
Acute lung injury 15.85 12.22 49 519441 1540 42100305
Colorectal cancer 15.82 12.22 23 519467 5015 42096830
Thrombosis 15.82 12.22 678 518812 67833 42034012
Atlantoaxial instability 15.81 12.22 23 519467 418 42101427
Lung infiltration 15.80 12.22 249 519241 13740 42088105
Transverse sinus thrombosis 15.79 12.22 11 519479 76 42101769
Atopy 15.79 12.22 36 519454 939 42100906
Orbital myositis 15.78 12.22 14 519476 143 42101702
Ventricular arrhythmia 15.77 12.22 33 519457 6246 42095599
Intervertebral disc degeneration 15.75 12.22 148 519342 7219 42094626
Mood altered 15.75 12.22 72 519418 10646 42091199
Transitional cell carcinoma metastatic 15.74 12.22 12 519478 97 42101748
Atrioventricular block complete 15.72 12.22 78 519412 11286 42090559
Joint range of motion decreased 15.71 12.22 154 519336 7599 42094246
Cardiac sarcoidosis 15.70 12.22 14 519476 144 42101701
Blood glucose decreased 15.70 12.22 105 519385 14114 42087731
Sickle cell anaemia with crisis 15.68 12.22 22 519468 4868 42096977
Skin ulcer 15.67 12.22 416 519074 25185 42076660
Pneumonia escherichia 15.67 12.22 29 519461 649 42101196
Infective myositis 15.64 12.22 12 519478 98 42101747
Chronic myelomonocytic leukaemia 15.62 12.22 31 519459 732 42101113
Coronavirus infection 15.59 12.22 113 519377 5101 42096744
Rash pruritic 15.57 12.22 302 519188 33301 42068544
Autoinflammatory disease 15.57 12.22 11 519479 78 42101767
Varicella virus test positive 15.55 12.22 17 519473 228 42101617
Skeletal injury 15.52 12.22 27 519463 575 42101270
Small intestinal stenosis 15.51 12.22 34 519456 863 42100982
Pyelonephritis acute 15.48 12.22 66 519424 2434 42099411
Inappropriate antidiuretic hormone secretion 15.46 12.22 128 519362 16413 42085432
Calciphylaxis 15.45 12.22 40 519450 1133 42100712
Muscle abscess 15.44 12.22 35 519455 909 42100936
Ileocaecal resection 15.44 12.22 22 519468 392 42101453
Hepatotoxicity 15.42 12.22 409 519081 24758 42077087
Intestinal obstruction 15.41 12.22 437 519053 26721 42075124
Sinusitis fungal 15.40 12.22 31 519459 740 42101105
Cerebral haematoma 15.38 12.22 28 519462 5582 42096263
Plasmodium falciparum infection 15.35 12.22 11 519479 80 42101765
Blood triglycerides increased 15.32 12.22 122 519368 15774 42086071
Heart rate increased 15.31 12.22 795 518695 52460 42049385
Pyomyositis 15.29 12.22 18 519472 263 42101582
Product administration interrupted 15.27 12.22 23 519467 4943 42096902
Tic 15.25 12.22 5 519485 2378 42099467
Emphysematous cystitis 15.14 12.22 18 519472 266 42101579
Bacteroides test positive 15.13 12.22 6 519484 9 42101836
Rabies 15.13 12.22 6 519484 9 42101836
Urinary tract infection neonatal 15.13 12.22 6 519484 9 42101836
Skin necrosis 15.12 12.22 130 519360 6184 42095661
Long QT syndrome 15.10 12.22 10 519480 3157 42098688
Restless legs syndrome 15.09 12.22 63 519427 9551 42092294
Dural arteriovenous fistula 15.08 12.22 10 519480 63 42101782
Systemic lupus erythematosus 15.07 12.22 177 519313 9147 42092698
Purulent pericarditis 15.06 12.22 8 519482 31 42101814
Disseminated intravascular coagulation 15.05 12.22 212 519278 24582 42077263
Liver function test abnormal 15.04 12.22 291 519199 32100 42069745
Blindness 14.99 12.22 305 519185 17673 42084172
Gastric ulcer haemorrhage, obstructive 14.98 12.22 7 519483 19 42101826
Stupor 14.97 12.22 10 519480 3143 42098702
Cytomegalovirus enteritis 14.94 12.22 28 519462 633 42101212
Muscle swelling 14.92 12.22 23 519467 441 42101404
Gastrointestinal mucormycosis 14.91 12.22 21 519469 370 42101475
Subperiosteal abscess 14.82 12.22 11 519479 85 42101760
Pleocytosis 14.82 12.22 28 519462 637 42101208
Respiratory disorder neonatal 14.77 12.22 3 519487 1967 42099878
Cytomegalovirus oesophagitis 14.77 12.22 26 519464 559 42101286
Sinus arrest 14.75 12.22 4 519486 2152 42099693
Carotid arteriosclerosis 14.74 12.22 5 519485 2327 42099518
Enterocolitis fungal 14.73 12.22 7 519483 20 42101825
Infection protozoal 14.73 12.22 7 519483 20 42101825
Colour blindness acquired 14.72 12.22 12 519478 108 42101737
Toxic encephalopathy 14.72 12.22 40 519450 6913 42094932
Haemoglobin decreased 14.70 12.22 1402 518088 131069 41970776
Incorrect product administration duration 14.69 12.22 31 519459 5849 42095996
Bone erosion 14.68 12.22 98 519392 4305 42097540
Device malfunction 14.65 12.22 89 519401 12238 42089607
Mycobacterial peritonitis 14.61 12.22 14 519476 159 42101686
Grip strength decreased 14.56 12.22 84 519406 3504 42098341
Diverticulitis intestinal perforated 14.54 12.22 18 519472 278 42101567
Herpes simplex oesophagitis 14.52 12.22 17 519473 247 42101598
Ileus 14.51 12.22 156 519334 18983 42082862
Rectal abscess 14.51 12.22 50 519440 1665 42100180
Pallor 14.51 12.22 256 519234 28630 42073215
Pruritus genital 14.49 12.22 7 519483 2632 42099213
Postoperative wound infection 14.48 12.22 118 519372 5524 42096321
Language disorder 14.48 12.22 6 519484 2469 42099376
Hypotonia 14.44 12.22 63 519427 9436 42092409
Central nervous system mass 14.42 12.22 32 519458 819 42101026
Passenger lymphocyte syndrome 14.42 12.22 11 519479 89 42101756
Hypothyroidism 14.37 12.22 290 519200 31794 42070051
Fibrosis 14.36 12.22 74 519416 2956 42098889
Headache 14.33 12.22 2634 516856 236735 41865110
Wall motion score index abnormal 14.32 12.22 32 519458 823 42101022
Eosinophilic myocarditis 14.32 12.22 43 519447 1330 42100515
Acute febrile neutrophilic dermatosis 14.29 12.22 53 519437 1831 42100014
Mucocutaneous leishmaniasis 14.29 12.22 12 519478 113 42101732
Exophthalmos 14.25 12.22 32 519458 826 42101019
Dysuria 14.24 12.22 280 519210 30816 42071029
Renal transplant 14.24 12.22 63 519427 2362 42099483
International normalised ratio decreased 14.23 12.22 21 519469 4551 42097294
Hypoxic-ischaemic encephalopathy 14.23 12.22 26 519464 5176 42096669
Factor V Leiden mutation 14.22 12.22 16 519474 222 42101623
Glomerulonephritis minimal lesion 14.20 12.22 28 519462 658 42101187
Reversible airways obstruction 14.20 12.22 26 519464 577 42101268
Swollen tongue 14.18 12.22 178 519312 21053 42080792
Carotid artery stenosis 14.14 12.22 28 519462 5408 42096437
Adrenocortical insufficiency acute 14.12 12.22 59 519431 2156 42099689
Peripheral T-cell lymphoma unspecified 14.11 12.22 26 519464 580 42101265
Ocular hypertension 14.11 12.22 38 519452 1103 42100742
Product physical issue 14.07 12.22 11 519479 3188 42098657
Hepatitis C RNA increased 14.06 12.22 18 519472 288 42101557
Device use error 14.05 12.22 11 519479 3186 42098659
Anaplastic large cell lymphoma T- and null-cell types recurrent 14.05 12.22 9 519481 53 42101792
Phaeohyphomycotic brain abscess 14.05 12.22 9 519481 53 42101792
Infective scleritis 14.05 12.22 9 519481 53 42101792
Pulmonary arterial hypertension 14.05 12.22 70 519420 10117 42091728
Hepatic failure 14.04 12.22 355 519135 37745 42064100
Alpha haemolytic streptococcal infection 14.01 12.22 53 519437 1849 42099996
Oesophageal candidiasis 14.01 12.22 117 519373 5518 42096327
Renal-limited thrombotic microangiopathy 14.01 12.22 17 519473 257 42101588
Endocarditis staphylococcal 14.00 12.22 29 519461 707 42101138
Proteus infection 13.99 12.22 43 519447 1347 42100498
Malignant neoplasm of conjunctiva 13.99 12.22 8 519482 37 42101808
Sleep disorder 13.98 12.22 463 519027 47632 42054213
Choriomeningitis lymphocytic 13.96 12.22 13 519477 142 42101703
Normochromic anaemia 13.96 12.22 12 519478 117 42101728
Follicular lymphoma 13.94 12.22 22 519468 431 42101414
Coronary artery stenosis 13.93 12.22 72 519418 10307 42091538
Vascular injury 13.92 12.22 18 519472 291 42101554
Lower respiratory tract infection 13.86 12.22 389 519101 40817 42061028
Migraine with aura 13.86 12.22 33 519457 886 42100959
Infective tenosynovitis 13.85 12.22 11 519479 95 42101750
Infective aneurysm 13.83 12.22 36 519454 1023 42100822
Injection site swelling 13.83 12.22 136 519354 16837 42085008
Sebaceous adenoma 13.83 12.22 8 519482 38 42101807
Meningoencephalitis viral 13.82 12.22 14 519476 171 42101674
Meningitis streptococcal 13.81 12.22 10 519480 74 42101771
Paraesthesia 13.79 12.22 743 518747 72716 42029129
Paronychia 13.78 12.22 19 519471 4236 42097609
Prostatic abscess 13.78 12.22 29 519461 715 42101130
Diverticulum intestinal haemorrhagic 13.77 12.22 10 519480 3009 42098836
Hantaviral infection 13.76 12.22 6 519484 13 42101832
Kaposi sarcoma inflammatory cytokine syndrome 13.75 12.22 13 519477 145 42101700
Bacterial sepsis 13.75 12.22 130 519360 6352 42095493
Pulmonary cavitation 13.75 12.22 41 519449 1263 42100582
Small intestinal obstruction 13.75 12.22 288 519202 16773 42085072
Oesophageal carcinoma 13.73 12.22 66 519424 9630 42092215
Herpes simplex encephalitis 13.73 12.22 20 519470 364 42101481
Drug specific antibody absent 13.71 12.22 10 519480 75 42101770
Diabetic neuropathy 13.70 12.22 21 519469 4481 42097364
Total lung capacity abnormal 13.70 12.22 97 519393 4346 42097499
Membranous-like glomerulopathy with masked IgG-kappa deposits 13.69 12.22 5 519485 5 42101840
Submaxillary gland enlargement 13.68 12.22 4 519486 0 42101845
Thermohyperaesthesia 13.68 12.22 4 519486 0 42101845
Limb deformity 13.68 12.22 25 519465 554 42101291
Salivary duct obstruction 13.68 12.22 4 519486 0 42101845
Metastases to pituitary gland 13.68 12.22 4 519486 0 42101845
Miliary pneumonia 13.68 12.22 4 519486 0 42101845
Erysipelothrix infection 13.68 12.22 4 519486 0 42101845
Bartonella test positive 13.68 12.22 4 519486 0 42101845
Eructation 13.64 12.22 29 519461 5457 42096388
Localised infection 13.63 12.22 335 519155 20038 42081807
Muscular weakness 13.61 12.22 856 518634 82642 42019203
Pulmonary eosinophilia 13.61 12.22 17 519473 265 42101580
Fatigue 13.54 12.22 4937 514553 430704 41671141
Keloid scar 13.54 12.22 9 519481 57 42101788
Metastases to muscle 13.53 12.22 16 519474 235 42101610
Chronic hepatitis 13.52 12.22 29 519461 725 42101120
Inspiratory capacity abnormal 13.49 12.22 11 519479 99 42101746
Mitral valve incompetence 13.49 12.22 132 519358 16357 42085488
Nephritis haemorrhagic 13.46 12.22 6 519484 14 42101831
Pulmonary vasculitis 13.46 12.22 126 519364 6140 42095705
Weight fluctuation 13.46 12.22 121 519369 5830 42096015
Gastrointestinal scarring 13.45 12.22 14 519476 177 42101668
Perforation 13.44 12.22 23 519467 483 42101362
Sputum abnormal 13.40 12.22 25 519465 563 42101282
Posture abnormal 13.37 12.22 7 519483 2514 42099331
Perirectal abscess 13.36 12.22 51 519439 1787 42100058
Small airways disease 13.36 12.22 8 519482 41 42101804
Bone marrow reticulin fibrosis 13.34 12.22 13 519477 151 42101694
Chronic myeloid leukaemia 13.34 12.22 63 519427 2429 42099416
Atrial flutter 13.33 12.22 140 519350 17111 42084734
Tricuspid valve incompetence 13.33 12.22 80 519410 11033 42090812
Red blood cell sedimentation rate increased 13.32 12.22 182 519308 9742 42092103
Tooth fracture 13.28 12.22 92 519398 4092 42097753
Increased viscosity of bronchial secretion 13.28 12.22 16 519474 240 42101605
Central nervous system vasculitis 13.27 12.22 26 519464 608 42101237
Hernia 13.24 12.22 199 519291 10874 42090971
Airway remodelling 13.23 12.22 32 519458 868 42100977
Dental plaque 13.23 12.22 5 519485 6 42101839
Paradoxical drug reaction 13.21 12.22 101 519389 4637 42097208
Sinus node dysfunction 13.21 12.22 24 519466 4788 42097057
Laryngeal mass 13.20 12.22 7 519483 27 42101818
Faecal calprotectin decreased 13.20 12.22 7 519483 27 42101818
Cholangitis sclerosing 13.19 12.22 52 519438 1850 42099995
Laparoscopic surgery 13.18 12.22 6 519484 15 42101830
Diverticular perforation 13.18 12.22 84 519406 3632 42098213
Respiratory tract infection 13.17 12.22 417 519073 25905 42075940
Actinic keratosis 13.15 12.22 108 519382 5068 42096777
Gastroenteritis Escherichia coli 13.12 12.22 33 519457 918 42100927
Treatment noncompliance 13.10 12.22 354 519136 37318 42064527
Colonic abscess 13.09 12.22 27 519463 656 42101189
Enterocolitis viral 13.09 12.22 22 519468 455 42101390
Tender joint count increased 13.09 12.22 14 519476 183 42101662
Tumour haemorrhage 13.08 12.22 15 519475 3623 42098222
Laboratory test abnormal 13.07 12.22 199 519291 22779 42079066
Phospholipidosis 13.06 12.22 9 519481 61 42101784
Burkholderia cepacia complex infection 13.04 12.22 18 519472 311 42101534
Major depression 13.04 12.22 29 519461 5369 42096476
Atypical haemolytic uraemic syndrome 13.03 12.22 24 519466 535 42101310
Radiation pneumonitis 13.01 12.22 10 519480 2923 42098922
Fungal abscess central nervous system 13.01 12.22 13 519477 156 42101689
Alopecia 12.99 12.22 265 519225 29011 42072834
Hilar lymphadenopathy 12.97 12.22 39 519451 1207 42100638
Staphylococcal bacteraemia 12.96 12.22 199 519291 10922 42090923
Myelitis transverse 12.94 12.22 41 519449 1306 42100539
Arrhythmogenic right ventricular dysplasia 12.92 12.22 8 519482 44 42101801
Gastrinoma 12.92 12.22 8 519482 44 42101801
Dermatitis bullous 12.91 12.22 56 519434 8400 42093445
Refractory cytopenia with unilineage dysplasia 12.89 12.22 23 519467 500 42101345
Oral candidiasis 12.89 12.22 247 519243 14158 42087687
Prostate cancer stage III 12.89 12.22 3 519487 1789 42100056
Immunoglobulin G4 related disease 12.88 12.22 16 519474 248 42101597
Prostate cancer stage I 12.87 12.22 8 519482 2613 42099232
Emotional disorder 12.86 12.22 37 519453 6277 42095568
Mental disorder 12.86 12.22 149 519341 17880 42083965
Mycobacterium kansasii infection 12.84 12.22 19 519471 351 42101494
Klebsiella sepsis 12.83 12.22 66 519424 2635 42099210
Splenic marginal zone lymphoma 12.83 12.22 7 519483 29 42101816
Complications of transplanted pancreas 12.83 12.22 7 519483 29 42101816
Choroidal osteoma 12.83 12.22 7 519483 29 42101816
Skin induration 12.82 12.22 52 519438 1875 42099970
Bundle branch block right 12.79 12.22 53 519437 8053 42093792
Hyperaesthesia 12.78 12.22 34 519456 5918 42095927
Glomerulosclerosis 12.77 12.22 31 519459 843 42101002
Rhinovirus infection 12.75 12.22 129 519361 6419 42095426
Osteoporotic fracture 12.74 12.22 44 519446 1467 42100378
Skin bacterial infection 12.74 12.22 16 519474 251 42101594
Lip oedema 12.72 12.22 12 519478 3172 42098673
Subcapsular renal haematoma 12.70 12.22 24 519466 546 42101299
Chronic graft versus host disease oral 12.70 12.22 20 519470 391 42101454
Bone marrow oedema 12.70 12.22 31 519459 846 42100999
Pyogenic granuloma 12.69 12.22 17 519473 285 42101560
Varices oesophageal 12.68 12.22 21 519469 4344 42097501
Periorbital cellulitis 12.68 12.22 19 519471 355 42101490
Basal cell carcinoma 12.68 12.22 365 519125 22368 42079477
Diffuse idiopathic skeletal hyperostosis 12.64 12.22 8 519482 46 42101799
Metastatic lymphoma 12.63 12.22 20 519470 393 42101452
Device failure 12.62 12.22 9 519481 2734 42099111
Dermatitis atopic 12.61 12.22 217 519273 12187 42089658
BK polyomavirus test positive 12.61 12.22 9 519481 65 42101780
Knee arthroplasty 12.60 12.22 163 519327 8618 42093227
Coagulopathy 12.58 12.22 192 519298 21970 42079875
Haemorrhagic stroke 12.57 12.22 47 519443 7355 42094490
Enterococcal bacteraemia 12.55 12.22 65 519425 2602 42099243
Azoospermia 12.54 12.22 23 519467 511 42101334
Lip scab 12.53 12.22 10 519480 87 42101758
Stomach mass 12.53 12.22 10 519480 87 42101758
Respiratory rate increased 12.53 12.22 197 519293 10865 42090980
Incontinence 12.52 12.22 42 519448 6788 42095057
Central obesity 12.51 12.22 28 519462 721 42101124
Ossicle disorder 12.47 12.22 7 519483 31 42101814
Skin hyperplasia 12.47 12.22 7 519483 31 42101814
Thinking abnormal 12.47 12.22 45 519445 7116 42094729
Lymphocyte count 12.45 12.22 15 519475 225 42101620
Pneumonia proteus 12.42 12.22 5 519485 8 42101837
Removal of internal fixation 12.42 12.22 5 519485 8 42101837
Meningitis haemophilus 12.42 12.22 5 519485 8 42101837
Drug specific antibody 12.41 12.22 20 519470 399 42101446
Hepatic artery thrombosis 12.41 12.22 16 519474 258 42101587
Pericarditis infective 12.39 12.22 9 519481 67 42101778
Pulmonary sarcoidosis 12.36 12.22 29 519461 771 42101074
Intestinal pseudo-obstruction 12.35 12.22 6 519484 2249 42099596
Pneumothorax spontaneous 12.35 12.22 30 519460 816 42101029
Rhonchi 12.35 12.22 55 519435 2068 42099777
Intestinal fistula 12.31 12.22 37 519453 1145 42100700
Scrotal ulcer 12.30 12.22 22 519468 479 42101366
Traumatic lung injury 12.30 12.22 40 519450 1292 42100553
Venous angioma of brain 12.30 12.22 7 519483 32 42101813
Visual impairment 12.30 12.22 416 519074 42697 42059148
T-cell type acute leukaemia 12.24 12.22 14 519476 198 42101647

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 2443.74 11.17 31044 1450676 1489496 107618083
Completed suicide 2243.06 11.17 297 1481423 242084 108865495
Off label use 1975.53 11.17 29569 1452151 1470616 107636963
Drug abuse 1549.84 11.17 257 1481463 177154 108930425
Toxicity to various agents 1437.40 11.17 2654 1479066 477901 108629678
Rheumatoid arthritis 1295.32 11.17 7640 1474080 291973 108815606
Post transplant lymphoproliferative disorder 1212.05 11.17 1260 1480460 14353 109093226
Condition aggravated 1163.22 11.17 14984 1466736 719852 108387727
Intentional overdose 1150.44 11.17 195 1481525 132306 108975273
Colitis ulcerative 1147.16 11.17 2925 1478795 74438 109033141
Death 1061.51 11.17 5285 1476435 693584 108413995
Overdose 930.79 11.17 1055 1480665 232739 108874840
Nocardiosis 924.44 11.17 782 1480938 6704 109100875
Asthma 879.93 11.17 6057 1475663 244234 108863345
Transplant rejection 849.73 11.17 1325 1480395 23242 109084337
Bradycardia 837.17 11.17 524 1481196 154993 108952586
Histoplasmosis disseminated 759.62 11.17 534 1481186 3365 109104214
Pneumocystis jirovecii pneumonia 753.72 11.17 1728 1479992 41007 109066572
Hyponatraemia 717.87 11.17 1128 1480592 216525 108891054
Hypotension 707.81 11.17 4118 1477602 519731 108587848
Disease recurrence 689.98 11.17 2085 1479635 58699 109048880
Depressed level of consciousness 669.66 11.17 333 1481387 111945 108995634
Electrocardiogram QT prolonged 668.43 11.17 311 1481409 108649 108998930
Polyomavirus-associated nephropathy 663.96 11.17 677 1481043 7524 109100055
Therapeutic product effect incomplete 658.48 11.17 5192 1476528 218613 108888966
Cytomegalovirus infection 652.63 11.17 1904 1479816 52540 109055039
Suicide attempt 651.67 11.17 284 1481436 103110 109004469
Constipation 649.86 11.17 2528 1479192 355258 108752321
Aspergillus infection 648.04 11.17 1202 1480518 24414 109083165
Drug effective for unapproved indication 615.77 11.17 851 1480869 13316 109094263
Arthralgia 607.49 11.17 14190 1467530 765442 108342137
Somnolence 605.65 11.17 2003 1479717 295446 108812133
Treatment failure 602.05 11.17 6018 1475702 271216 108836363
Joint swelling 585.47 11.17 8751 1472969 434094 108673485
Drug interaction 577.09 11.17 4125 1477595 496058 108611521
Fall 574.15 11.17 5243 1476477 598239 108509340
Acute kidney injury 562.74 11.17 5619 1476101 629811 108477768
Wheezing 545.28 11.17 5522 1476198 249708 108857871
Rebound effect 543.62 11.17 821 1480899 13985 109093594
Hypoglycaemia 537.99 11.17 458 1481262 115646 108991933
Kidney transplant rejection 537.51 11.17 731 1480989 11256 109096323
Intentional product use issue 528.37 11.17 5361 1476359 242545 108865034
Cardio-respiratory arrest 515.01 11.17 475 1481245 115361 108992218
Obstructive airways disorder 506.93 11.17 1565 1480155 44584 109062995
Cytomegalovirus viraemia 504.93 11.17 877 1480843 16887 109090692
Loss of personal independence in daily activities 496.13 11.17 3578 1478142 146442 108961137
Strongyloidiasis 488.63 11.17 457 1481263 4529 109103050
Seizure 485.01 11.17 1440 1480280 219745 108887834
Epstein-Barr virus infection 473.66 11.17 879 1480841 17859 109089720
Sedation 470.88 11.17 172 1481548 69511 109038068
Full blood count abnormal 465.78 11.17 1731 1479989 54321 109053258
Rhabdomyolysis 453.69 11.17 567 1481153 119834 108987745
Nausea 453.22 11.17 12855 1468865 1222835 107884744
Dizziness 450.23 11.17 6614 1475106 691579 108416000
Intentional product misuse 449.39 11.17 677 1481043 132227 108975352
Serotonin syndrome 429.51 11.17 129 1481591 59024 109048555
Loss of consciousness 428.95 11.17 1280 1480440 195026 108912553
Cryptococcosis 424.38 11.17 409 1481311 4222 109103357
Cardiac arrest 421.99 11.17 1294 1480426 195459 108912120
Blood pressure fluctuation 420.02 11.17 2051 1479669 72773 109034806
Phaeohyphomycosis 411.01 11.17 267 1481453 1447 109106132
Hepatic function abnormal 407.91 11.17 357 1481363 88938 109018641
Malacoplakia 402.12 11.17 235 1481485 1017 109106562
Weight increased 401.40 11.17 7872 1473848 411772 108695807
White blood cell count decreased 375.76 11.17 1686 1480034 227704 108879875
Therapeutic product effect decreased 366.07 11.17 4937 1476783 239379 108868200
Productive cough 364.57 11.17 2703 1479017 111602 108995977
Anaemia 361.32 11.17 5157 1476563 541929 108565650
Histoplasmosis 359.55 11.17 306 1481414 2647 109104932
Vomiting 358.81 11.17 9375 1472345 901300 108206279
Dehydration 354.53 11.17 2240 1479480 277271 108830308
Hallucination 344.53 11.17 515 1481205 100917 109006662
Neutrophil count decreased 343.34 11.17 688 1481032 120253 108987326
Coma 341.97 11.17 662 1481058 117207 108990372
Syncope 340.57 11.17 1474 1480246 201062 108906517
Orthostatic hypotension 337.82 11.17 237 1481483 66012 109041567
Agitation 334.94 11.17 627 1481093 112424 108995155
Lactic acidosis 332.28 11.17 454 1481266 92357 109015222
Suicidal ideation 331.81 11.17 464 1481256 93473 109014106
Cognitive disorder 327.71 11.17 414 1481306 87097 109020482
Arthropathy 327.16 11.17 5543 1476177 281979 108825600
Neuroleptic malignant syndrome 323.94 11.17 38 1481682 34021 109073558
Intentional self-injury 318.44 11.17 58 1481662 37371 109070208
Respiratory arrest 310.11 11.17 199 1481521 58100 109049479
Diffuse large B-cell lymphoma recurrent 305.25 11.17 399 1481321 5900 109101679
Drug level below therapeutic 299.34 11.17 551 1481169 11122 109096457
Device expulsion 297.48 11.17 33 1481687 30858 109076721
Hyperkalaemia 294.77 11.17 888 1480832 134908 108972671
Cytomegalovirus colitis 294.72 11.17 416 1481304 6645 109100934
Cough 293.67 11.17 8182 1473538 453459 108654120
Blastomycosis 292.46 11.17 185 1481535 950 109106629
Pulmonary nocardiosis 290.98 11.17 258 1481462 2371 109105208
Meningitis cryptococcal 287.69 11.17 337 1481383 4425 109103154
Haemophagocytic lymphohistiocytosis 287.17 11.17 1004 1480716 30555 109077024
Altered state of consciousness 282.33 11.17 215 1481505 57411 109050168
COVID-19 280.77 11.17 4730 1476990 240330 108867249
Product use in unapproved indication 278.35 11.17 7907 1473813 439470 108668109
Tachycardia 274.32 11.17 1842 1479878 224803 108882776
Malignant neoplasm progression 272.83 11.17 1305 1480415 173262 108934317
Platelet count decreased 272.40 11.17 1886 1479834 228557 108879022
Palmar-plantar erythrodysaesthesia syndrome 270.92 11.17 105 1481615 40920 109066659
Brain abscess 270.84 11.17 391 1481329 6383 109101196
Sputum discoloured 269.12 11.17 906 1480814 27039 109080540
Decreased appetite 265.71 11.17 4629 1477091 471217 108636362
Aggression 265.29 11.17 241 1481479 58969 109048610
Trichodysplasia spinulosa 262.72 11.17 168 1481552 882 109106697
Hypokalaemia 260.67 11.17 1407 1480313 181041 108926538
Faecal calprotectin increased 258.73 11.17 381 1481339 6338 109101241
Blood creatine phosphokinase increased 258.05 11.17 361 1481359 72716 109034863
Drug intolerance 257.92 11.17 7203 1474517 399309 108708270
Unresponsive to stimuli 255.70 11.17 286 1481434 63504 109044075
International normalised ratio increased 255.49 11.17 483 1481237 86289 109021290
Respiratory depression 254.78 11.17 58 1481662 31943 109075636
Bronchopulmonary aspergillosis 253.76 11.17 929 1480791 28934 109078645
Blood pressure systolic increased 251.94 11.17 1940 1479780 81051 109026528
Sedation complication 245.26 11.17 4 1481716 19851 109087728
Hyperhidrosis 244.67 11.17 1487 1480233 185811 108921768
Disseminated cryptococcosis 244.12 11.17 235 1481485 2422 109105157
Varicella zoster virus infection 242.19 11.17 359 1481361 6009 109101570
Pain 241.33 11.17 15347 1466373 939608 108167971
Circulatory collapse 240.91 11.17 138 1481582 42855 109064724
Poisoning deliberate 239.28 11.17 34 1481686 26297 109081282
Myocardial infarction 238.54 11.17 1549 1480171 190534 108917045
Mucormycosis 238.46 11.17 474 1481246 10154 109097425
Synovitis 238.44 11.17 5071 1476649 269021 108838558
Balance disorder 237.64 11.17 784 1480936 115776 108991803
Smooth muscle cell neoplasm 237.14 11.17 177 1481543 1240 109106339
Cardiac failure 236.08 11.17 1507 1480213 186119 108921460
Poisoning 235.25 11.17 51 1481669 29054 109078525
Confusional state 233.45 11.17 4650 1477070 464030 108643549
Complications of transplanted kidney 232.16 11.17 383 1481337 7059 109100520
Drug level decreased 227.39 11.17 654 1481066 17894 109089685
West Nile viral infection 227.21 11.17 168 1481552 1158 109106421
Metabolic acidosis 224.62 11.17 641 1481079 99103 109008476
Drug ineffective for unapproved indication 223.71 11.17 2234 1479486 100604 109006975
Tremor 222.62 11.17 1689 1480031 200543 108907036
Immunosuppressant drug level increased 222.29 11.17 488 1481232 11236 109096343
Renal transplant failure 222.00 11.17 224 1481496 2456 109105123
Cushingoid 221.49 11.17 487 1481233 11225 109096354
Osteoporosis 220.95 11.17 1956 1479764 85196 109022383
Therapy partial responder 220.35 11.17 1033 1480687 36028 109071551
Human herpesvirus 8 infection 219.91 11.17 190 1481530 1681 109105898
Contraindicated product administered 219.42 11.17 4604 1477116 243663 108863916
Dyskinesia 218.12 11.17 220 1481500 51226 109056353
Forced expiratory volume decreased 217.25 11.17 519 1481201 12657 109094922
Inappropriate schedule of product administration 217.19 11.17 3886 1477834 199751 108907828
Arthritis 216.41 11.17 3300 1478420 164286 108943293
Ventricular fibrillation 213.01 11.17 146 1481574 41167 109066412
Steroid diabetes 212.60 11.17 305 1481415 4949 109102630
Systemic lupus erythematosus 212.38 11.17 4678 1477042 249660 108857919
Gastrointestinal haemorrhage 207.94 11.17 1330 1480390 164188 108943391
Frequent bowel movements 207.41 11.17 1652 1480068 69738 109037841
Sopor 206.65 11.17 116 1481604 36430 109071149
Epstein-Barr viraemia 205.84 11.17 247 1481473 3332 109104247
Alternaria infection 202.74 11.17 141 1481579 871 109106708
Hypomagnesaemia 200.68 11.17 311 1481409 60059 109047520
Infection 200.37 11.17 6310 1475410 355890 108751689
Sinusitis 199.97 11.17 5299 1476421 291389 108816190
Defaecation urgency 199.74 11.17 393 1481327 8354 109099225
Mycobacterium avium complex infection 199.09 11.17 314 1481406 5563 109102016
Nasopharyngitis 197.03 11.17 6788 1474932 387573 108720006
Polyomavirus viraemia 196.93 11.17 238 1481482 3236 109104343
Septic shock 196.53 11.17 3084 1478636 154444 108953135
Haematemesis 196.01 11.17 305 1481415 58803 109048776
BK virus infection 195.71 11.17 497 1481223 12609 109094970
Focal segmental glomerulosclerosis 195.36 11.17 259 1481461 3886 109103693
Drug withdrawal syndrome 192.87 11.17 137 1481583 37917 109069662
Pseudomonas infection 192.52 11.17 812 1480908 27041 109080538
Epistaxis 192.00 11.17 995 1480725 129377 108978202
Bronchiectasis 191.12 11.17 981 1480739 35512 109072067
Cardiac failure congestive 188.32 11.17 1216 1480504 149784 108957795
Wrong technique in product usage process 186.10 11.17 576 1481144 86772 109020807
Therapeutic reaction time decreased 185.72 11.17 287 1481433 4992 109102587
Disturbance in attention 185.23 11.17 342 1481378 61653 109045926
Vaccination failure 185.15 11.17 197 1481523 2309 109105270
Restlessness 183.05 11.17 294 1481426 55965 109051614
Angioedema 182.41 11.17 690 1481030 97810 109009769
Therapeutic response shortened 181.36 11.17 832 1480888 28751 109078828
Extrapyramidal disorder 180.74 11.17 80 1481640 28787 109078792
Hepatitis B reactivation 180.36 11.17 344 1481376 7140 109100439
JC virus infection 179.70 11.17 283 1481437 5007 109102572
Chronic allograft nephropathy 178.50 11.17 179 1481541 1947 109105632
Musculoskeletal stiffness 178.11 11.17 4961 1476759 274861 108832718
Blood pressure diastolic abnormal 177.97 11.17 752 1480968 25063 109082516
Ascites 177.85 11.17 641 1481079 92167 109015412
Disseminated blastomycosis 177.14 11.17 99 1481621 386 109107193
Blood pressure increased 175.33 11.17 4619 1477101 253754 108853825
Therapy non-responder 174.89 11.17 3022 1478698 154285 108953294
Herpes zoster 173.41 11.17 2217 1479503 106162 109001417
Parkinsonism 173.10 11.17 42 1481678 22145 109085434
Melaena 173.00 11.17 418 1481302 68339 109039240
Miosis 172.71 11.17 41 1481679 21942 109085637
Infection reactivation 172.66 11.17 242 1481478 3839 109103740
Swelling 169.74 11.17 6020 1475700 345021 108762558
Cerebrovascular accident 169.30 11.17 1581 1480139 179703 108927876
Dystonia 168.82 11.17 67 1481653 25738 109081841
Nasal polyps 168.22 11.17 472 1481248 12728 109094851
Mucous stools 166.58 11.17 316 1481404 6531 109101048
Dysarthria 165.88 11.17 574 1481146 83547 109024032
Dry skin 165.13 11.17 810 1480910 106843 109000736
Aspartate aminotransferase increased 163.38 11.17 1363 1480357 158573 108949006
Sleep disorder due to a general medical condition 162.53 11.17 1226 1480494 50886 109056693
Mycobacterial infection 162.26 11.17 245 1481475 4172 109103407
Diarrhoea 162.08 11.17 13108 1468612 1126397 107981182
Mydriasis 161.43 11.17 48 1481672 22109 109085470
Multiple sclerosis relapse 161.15 11.17 265 1481455 49975 109057604
Epidermodysplasia verruciformis 161.09 11.17 91 1481629 364 109107215
Urinary retention 160.46 11.17 443 1481277 69240 109038339
Bacillary angiomatosis 160.22 11.17 85 1481635 291 109107288
Disorientation 159.97 11.17 453 1481267 70218 109037361
Anaphylactic shock 159.72 11.17 278 1481442 51268 109056311
Progressive multifocal leukoencephalopathy 159.06 11.17 710 1481010 24246 109083333
Escherichia infection 158.96 11.17 687 1481033 23129 109084450
Cerebral infarction 157.52 11.17 283 1481437 51555 109056024
Hand deformity 156.33 11.17 3934 1477786 214572 108893007
Epstein-Barr virus associated lymphoproliferative disorder 153.67 11.17 250 1481470 4552 109103027
Infusion related reaction 153.33 11.17 6406 1475314 374756 108732823
Candida infection 151.72 11.17 1133 1480587 46876 109060703
Mycobacterium chelonae infection 151.66 11.17 196 1481524 2864 109104715
General physical health deterioration 151.24 11.17 4439 1477281 420856 108686723
Humoral immune defect 151.06 11.17 105 1481615 648 109106931
Cerebral haemorrhage 149.61 11.17 413 1481307 64555 109043024
Pneumonia aspiration 149.15 11.17 571 1481149 80662 109026917
Product prescribing error 149.11 11.17 288 1481432 51043 109056536
Blood calcium decreased 148.88 11.17 156 1481564 35689 109071890
Heart rate decreased 148.51 11.17 1730 1479990 81026 109026553
Lung transplant rejection 148.37 11.17 155 1481565 1776 109105803
Muscle rigidity 148.26 11.17 68 1481652 23963 109083616
Posterior reversible encephalopathy syndrome 148.24 11.17 867 1480853 32994 109074585
Lethargy 147.06 11.17 698 1481022 92878 109014701
Delirium 146.06 11.17 1133 1480587 133892 108973687
Acute myocardial infarction 145.50 11.17 602 1481118 83175 109024404
Stevens-Johnson syndrome 145.27 11.17 253 1481467 46648 109060931
Diffuse large B-cell lymphoma 143.11 11.17 504 1481216 15394 109092185
Pemphigus 142.97 11.17 3827 1477893 210743 108896836
Labelled drug-drug interaction medication error 142.67 11.17 110 1481610 29192 109078387
Blood immunoglobulin E increased 142.50 11.17 312 1481408 7170 109100409
Disease progression 141.93 11.17 4278 1477442 239756 108867823
Poor venous access 141.04 11.17 677 1481043 23845 109083734
Creatinine renal clearance decreased 140.50 11.17 58 1481662 21757 109085822
American trypanosomiasis 140.46 11.17 94 1481626 540 109107039
Akathisia 140.34 11.17 29 1481691 17084 109090495
Accidental overdose 140.22 11.17 303 1481417 51531 109056048
Blood pressure systolic abnormal 140.01 11.17 682 1481038 24168 109083411
Sinus bradycardia 139.38 11.17 114 1481606 29369 109078210
Pneumonia cryptococcal 138.99 11.17 171 1481549 2371 109105208
Cataract 138.82 11.17 1653 1480067 77832 109029747
Myelosuppression 138.33 11.17 721 1480999 93619 109013960
Inflammation 138.19 11.17 3479 1478241 189759 108917820
Hallucination, auditory 137.81 11.17 92 1481628 26305 109081274
Suspected suicide 137.24 11.17 20 1481700 15179 109092400
Subdural haematoma 136.94 11.17 172 1481548 36282 109071297
Uveitis 136.37 11.17 615 1481105 21095 109086484
Pulmonary function test abnormal 135.82 11.17 242 1481478 4758 109102821
Weight decreased 135.67 11.17 7617 1474103 460440 108647139
Device difficult to use 134.73 11.17 42 1481678 18763 109088816
Substance abuse 134.69 11.17 8 1481712 12455 109095124
Haematochezia 134.47 11.17 2236 1479484 113288 108994291
Product substitution issue 133.59 11.17 71 1481649 22990 109084589
Generalised tonic-clonic seizure 133.21 11.17 338 1481382 54342 109053237
Secondary immunodeficiency 133.08 11.17 231 1481489 4445 109103134
Clostridium difficile infection 132.13 11.17 1170 1480550 50959 109056620
Withdrawal syndrome 132.11 11.17 135 1481585 31245 109076334
Cat scratch disease 131.95 11.17 92 1481628 571 109107008
Hepatic cytolysis 131.28 11.17 344 1481376 54709 109052870
Alanine aminotransferase increased 130.84 11.17 1705 1480015 182068 108925511
Product administration error 130.25 11.17 185 1481535 37032 109070547
Drug reaction with eosinophilia and systemic symptoms 129.81 11.17 611 1481109 81484 109026095
Coronary artery disease 129.64 11.17 507 1481213 71183 109036396
Scedosporium infection 129.02 11.17 162 1481558 2296 109105283
Peripheral swelling 128.59 11.17 6633 1475087 397401 108710178
Exposure to toxic agent 128.32 11.17 12 1481708 12846 109094733
Blood pressure diastolic increased 128.21 11.17 546 1481174 18261 109089318
Fungal infection 128.10 11.17 1139 1480581 49667 109057912
Cardiogenic shock 127.97 11.17 370 1481350 56968 109050611
Accidental exposure to product 127.41 11.17 302 1481418 49706 109057873
Osteonecrosis 126.41 11.17 830 1480890 32911 109074668
Nasal congestion 126.32 11.17 1934 1479786 96348 109011231
Arrhythmia 125.84 11.17 492 1481228 69083 109038496
Hypogammaglobulinaemia 125.57 11.17 568 1481152 19508 109088071
Gamma-glutamyltransferase increased 125.20 11.17 412 1481308 60897 109046682
Tardive dyskinesia 124.65 11.17 17 1481703 13562 109094017
Product dose omission issue 123.43 11.17 3323 1478397 318459 108789120
Klebsiella infection 122.84 11.17 563 1481157 19446 109088133
Toxic epidermal necrolysis 122.31 11.17 372 1481348 56355 109051224
Hallucination, visual 121.44 11.17 215 1481505 39390 109068189
Human ehrlichiosis 121.20 11.17 90 1481630 625 109106954
Graft loss 121.15 11.17 117 1481603 1211 109106368
Dysgeusia 120.85 11.17 504 1481216 69481 109038098
Oedema peripheral 120.41 11.17 3416 1478304 325244 108782335
Temperature regulation disorder 120.28 11.17 15 1481705 12811 109094768
Red blood cell sedimentation rate abnormal 120.19 11.17 647 1481073 23862 109083717
Steroid dependence 120.11 11.17 315 1481405 8154 109099425
Abnormal behaviour 119.63 11.17 212 1481508 38827 109068752
Delayed graft function 119.46 11.17 209 1481511 4048 109103531
Parvovirus B19 infection 119.16 11.17 169 1481551 2712 109104867
Atrial fibrillation 118.84 11.17 2263 1479457 227379 108880200
Blood alkaline phosphatase increased 118.70 11.17 517 1481203 70418 109037161
Blood bilirubin increased 118.61 11.17 568 1481152 75404 109032175
Neutropenia 118.38 11.17 3971 1477749 370649 108736930
Disseminated tuberculosis 117.25 11.17 231 1481489 4915 109102664
Thrombocytopenia 116.96 11.17 3670 1478050 345215 108762364
Renal graft infection 116.50 11.17 91 1481629 688 109106891
Mycobacterium haemophilum infection 116.30 11.17 88 1481632 631 109106948
Ventricular tachycardia 115.83 11.17 317 1481403 49692 109057887
Heart rate increased 115.72 11.17 2632 1479088 141202 108966377
Depression 115.56 11.17 3301 1478419 314034 108793545
Device dislocation 114.56 11.17 154 1481566 31550 109076029
Immunosuppression 114.50 11.17 507 1481213 17252 109090327
Coccidioidomycosis 114.48 11.17 125 1481595 1512 109106067
Salivary hypersecretion 114.35 11.17 45 1481675 17376 109090203
Palpitations 114.12 11.17 1475 1480245 157737 108949842
COVID-19 pneumonia 113.11 11.17 869 1480851 36274 109071305
Cytomegalovirus chorioretinitis 112.42 11.17 276 1481444 6852 109100727
Torsade de pointes 112.40 11.17 83 1481637 22517 109085062
Fistula 112.01 11.17 454 1481266 14845 109092734
Listeriosis 111.88 11.17 162 1481558 2652 109104927
Blood pressure diastolic decreased 111.76 11.17 844 1480876 35041 109072538
Upper gastrointestinal haemorrhage 111.27 11.17 324 1481396 49772 109057807
Anal fissure 111.21 11.17 338 1481382 9543 109098036
Hypothermia 110.90 11.17 113 1481607 26189 109081390
Red blood cell sedimentation rate increased 110.51 11.17 1566 1480154 76736 109030843
Therapeutic response decreased 110.19 11.17 1862 1479858 94637 109012942
Breath sounds abnormal 108.33 11.17 646 1481074 24758 109082821
Transplant dysfunction 108.30 11.17 300 1481420 8028 109099551
Nightmare 107.78 11.17 224 1481496 38639 109068940
Herpes simplex 107.73 11.17 458 1481262 15306 109092273
Dissociation 107.33 11.17 6 1481714 9836 109097743
Kidney fibrosis 107.23 11.17 203 1481517 4189 109103390
Central nervous system lymphoma 106.40 11.17 165 1481555 2879 109104700
Enterococcal infection 106.31 11.17 547 1481173 19819 109087760
Acute respiratory distress syndrome 105.40 11.17 1134 1480586 52064 109055515
Myoclonus 104.96 11.17 175 1481545 32823 109074756
Polymyalgia rheumatica 104.33 11.17 252 1481468 6190 109101389
Visceral leishmaniasis 103.97 11.17 123 1481597 1633 109105946
Pneumonia cytomegaloviral 103.10 11.17 263 1481457 6691 109100888
Ureaplasma infection 102.84 11.17 115 1481605 1431 109106148
Epilepsy 102.77 11.17 853 1480867 99356 109008223
Impaired quality of life 102.09 11.17 721 1480999 29296 109078283
Product monitoring error 102.02 11.17 4 1481716 8923 109098656
Abscess 101.87 11.17 674 1481046 26795 109080784
Activated partial thromboplastin time prolonged 101.44 11.17 90 1481630 22278 109085301
Influenza 101.42 11.17 2976 1478744 166125 108941454
Euglycaemic diabetic ketoacidosis 101.08 11.17 17 1481703 11606 109095973
Heart transplant rejection 101.03 11.17 130 1481590 1891 109105688
Renal tubular atrophy 100.84 11.17 138 1481582 2138 109105441
Gastrointestinal disorder 100.78 11.17 4082 1477638 237870 108869709
Rhinitis allergic 100.35 11.17 491 1481229 17431 109090148
Aphthous ulcer 100.31 11.17 553 1481167 20583 109086996
Legionella infection 100.24 11.17 91 1481629 865 109106714
Inappropriate antidiuretic hormone secretion 100.01 11.17 188 1481532 33663 109073916
Sensitivity to weather change 100.01 11.17 329 1481391 9699 109097880
Bronchial wall thickening 99.98 11.17 165 1481555 3042 109104537
Lymphadenopathy 99.22 11.17 1299 1480421 62536 109045043
Arthritis bacterial 98.24 11.17 344 1481376 10476 109097103
Transient ischaemic attack 97.77 11.17 482 1481238 63500 109044079
Adenovirus infection 97.64 11.17 347 1481373 10647 109096932
Respiratory tract congestion 96.24 11.17 726 1480994 30131 109077448
Pericarditis 96.23 11.17 3718 1478002 215396 108892183
Loss of therapeutic response 96.17 11.17 142 1481578 2368 109105211
Pulmonary mass 95.98 11.17 840 1480880 36461 109071118
Glossodynia 95.14 11.17 3757 1477963 218247 108889332
Blood phosphorus increased 95.10 11.17 50 1481670 16290 109091289
New onset diabetes after transplantation 94.67 11.17 63 1481657 358 109107221
Vasculitis 94.47 11.17 812 1480908 35061 109072518
Obliterative bronchiolitis 93.28 11.17 174 1481546 3549 109104030
Medication error 93.22 11.17 931 1480789 104435 109003144
Atrioventricular block first degree 92.95 11.17 37 1481683 14188 109093391
Schizophrenia 92.90 11.17 93 1481627 21733 109085846
Renal failure 92.63 11.17 2318 1479402 224256 108883323
Delusion 92.49 11.17 109 1481611 23646 109083933
Rash maculo-papular 92.36 11.17 598 1481122 73624 109033955
Upper-airway cough syndrome 92.08 11.17 439 1481281 15418 109092161
Dementia 91.74 11.17 178 1481542 31495 109076084
Drug specific antibody present 91.66 11.17 285 1481435 8149 109099430
Hepatitis B 91.11 11.17 310 1481410 9302 109098277
Oropharyngeal pain 91.00 11.17 2416 1479304 132860 108974719
Philadelphia positive chronic myeloid leukaemia 90.31 11.17 47 1481673 153 109107426
Multiple drug therapy 90.22 11.17 4 1481716 8010 109099569
Cryptosporidiosis infection 90.07 11.17 93 1481627 1050 109106529
Rheumatoid nodule 89.70 11.17 521 1481199 19775 109087804
Metastases to liver 89.11 11.17 215 1481505 35171 109072408
Pneumocystis jirovecii infection 88.98 11.17 188 1481532 4212 109103367
Haematotoxicity 88.56 11.17 534 1481186 20548 109087031
Hypocalcaemia 88.46 11.17 513 1481207 64853 109042726
Cerebral aspergillosis 87.87 11.17 130 1481590 2172 109105407
Sexual dysfunction 87.74 11.17 7 1481713 8523 109099056
Toxic skin eruption 87.44 11.17 146 1481574 27369 109080210
Renal impairment 87.35 11.17 1891 1479829 186554 108921025
Electrocardiogram abnormal 86.40 11.17 74 1481646 18635 109088944
Sarcoidosis 86.37 11.17 366 1481354 12213 109095366
Amnesia 86.08 11.17 949 1480771 104459 109003120
Status epilepticus 85.85 11.17 184 1481536 31387 109076192
Blood creatinine increased 85.71 11.17 1832 1479888 181057 108926522
Babesiosis 85.46 11.17 63 1481657 432 109107147
Memory impairment 85.40 11.17 1997 1479723 194947 108912632
Asphyxia 84.97 11.17 42 1481678 14173 109093406
Discomfort 84.76 11.17 3602 1478118 211105 108896474
Liver transplant rejection 84.63 11.17 172 1481548 3746 109103833
Eosinophilic granulomatosis with polyangiitis 84.61 11.17 325 1481395 10361 109097218
Mycoplasma infection 84.56 11.17 99 1481621 1299 109106280
Anti-cyclic citrullinated peptide antibody positive 84.45 11.17 3107 1478613 178877 108928702
Drug therapy 84.24 11.17 3 1481717 7288 109100291
Nasal oedema 83.69 11.17 241 1481479 6598 109100981
Lip swelling 83.13 11.17 372 1481348 50295 109057284
Product use issue 83.05 11.17 5035 1476685 306660 108800919
Acanthamoeba infection 82.98 11.17 68 1481652 555 109107024
Ketoacidosis 82.91 11.17 17 1481703 10070 109097509
Hypophosphataemia 82.47 11.17 203 1481517 32979 109074600
Blood urea increased 82.26 11.17 417 1481303 54540 109053039
Electrocardiogram QRS complex prolonged 81.65 11.17 36 1481684 12985 109094594
Ill-defined disorder 81.51 11.17 2713 1479007 154140 108953439
Eye infection toxoplasmal 80.98 11.17 73 1481647 687 109106892
Tuberculosis 80.35 11.17 459 1481261 17315 109090264
Necrotising retinitis 80.31 11.17 103 1481617 1493 109106086
Disseminated strongyloidiasis 80.13 11.17 66 1481654 543 109107036
Bladder cancer 79.12 11.17 93 1481627 20199 109087380
Jaundice 79.04 11.17 467 1481253 58769 109048810
Cholestasis 78.67 11.17 523 1481197 63995 109043584
Neuropathy peripheral 78.53 11.17 1815 1479905 177462 108930117
Enterobacter infection 78.22 11.17 212 1481508 5599 109101980
Cytomegalovirus gastrointestinal infection 78.04 11.17 70 1481650 654 109106925
Human polyomavirus infection 77.94 11.17 108 1481612 1694 109105885
Muscle spasms 77.93 11.17 2992 1478728 275165 108832414
Lupus nephritis 77.70 11.17 184 1481536 4461 109103118
Therapy interrupted 77.47 11.17 373 1481347 49449 109058130
Flushing 77.39 11.17 964 1480756 103772 109003807
Myalgia 77.23 11.17 2328 1479392 220053 108887526
Full blood count decreased 76.20 11.17 201 1481519 31898 109075681
Osteoporotic fracture 76.19 11.17 199 1481521 5138 109102441
Pseudoaneurysm infection 75.93 11.17 43 1481677 173 109107406
Device adhesion issue 75.89 11.17 16 1481704 9294 109098285
Ear pruritus 75.84 11.17 242 1481478 7018 109100561
Fluid retention 75.84 11.17 852 1480868 93455 109014124
Toxoplasmosis 75.75 11.17 147 1481573 3092 109104487
Pulmonary oedema 75.31 11.17 924 1480796 99735 109007844
Diabetes mellitus 75.13 11.17 1803 1479917 97578 109010001
Encephalitis viral 74.67 11.17 140 1481580 2867 109104712
Respiratory failure 74.41 11.17 3564 1478156 211768 108895811
Antipsychotic drug level increased 74.32 11.17 5 1481715 7010 109100569
Restless legs syndrome 74.32 11.17 135 1481585 24491 109083088
Blood pressure decreased 73.96 11.17 1090 1480630 114001 108993578
Sudden death 73.38 11.17 134 1481586 24261 109083318
Pulmonary mucormycosis 73.29 11.17 115 1481605 2028 109105551
Body temperature decreased 72.55 11.17 786 1480934 36149 109071430
Erectile dysfunction 72.40 11.17 85 1481635 18471 109089108
Rhinorrhoea 72.36 11.17 1845 1479875 100821 109006758
Bradypnoea 72.30 11.17 14 1481706 8635 109098944
Respiratory tract infection 72.20 11.17 1355 1480365 70262 109037317
Panniculitis 72.15 11.17 405 1481315 15177 109092402
Colectomy 71.69 11.17 172 1481548 4206 109103373
Subarachnoid haemorrhage 71.27 11.17 185 1481535 29517 109078062
Pallor 71.26 11.17 453 1481267 56014 109051565
Rhodococcus infection 71.14 11.17 57 1481663 449 109107130
Psychotic disorder 70.96 11.17 396 1481324 50541 109057038
Plasma cell myeloma 70.93 11.17 522 1481198 62414 109045165
Pulmonary function test decreased 70.86 11.17 267 1481453 8433 109099146
Myocardial ischaemia 70.51 11.17 158 1481562 26526 109081053
Paraesthesia 70.47 11.17 3007 1478713 273514 108834065
Complication of device insertion 70.39 11.17 16 1481704 8822 109098757
Liver function test abnormal 70.21 11.17 588 1481132 68362 109039217
Hepatic failure 70.08 11.17 586 1481134 68153 109039426
Device leakage 69.90 11.17 67 1481653 15981 109091598
Erythema multiforme 69.81 11.17 109 1481611 20988 109086591
Wound 69.73 11.17 3825 1477895 230612 108876967
Sporotrichosis 69.54 11.17 35 1481685 104 109107475
Granulomatosis with polyangiitis 69.29 11.17 148 1481572 3342 109104237
Cyanosis 69.27 11.17 188 1481532 29553 109078026
Abdominal discomfort 69.24 11.17 6153 1475567 387705 108719874
Epstein-Barr virus associated lymphoma 69.12 11.17 98 1481622 1572 109106007
Intercepted product preparation error 69.04 11.17 6 1481714 6814 109100765
Sensitisation 68.97 11.17 164 1481556 3987 109103592
Blood glucose increased 68.72 11.17 1305 1480415 131191 108976388
Sinus tachycardia 68.66 11.17 334 1481386 44159 109063420
Myopathy 68.38 11.17 570 1481150 24390 109083189
Cerebral toxoplasmosis 67.94 11.17 138 1481582 3004 109104575
Unintentional medical device removal 67.48 11.17 18 1481702 8905 109098674
Fungal skin infection 67.14 11.17 232 1481488 7017 109100562
Viraemia 67.01 11.17 161 1481559 3941 109103638
Oral herpes 66.40 11.17 758 1480962 35322 109072257
Skin lesion 66.33 11.17 1016 1480704 50615 109056964
Drug dose omission by device 66.32 11.17 58 1481662 14458 109093121
Hypernatraemia 66.09 11.17 85 1481635 17748 109089831
Respiratory disorder 66.02 11.17 1333 1480387 70049 109037530
Gastroenteritis norovirus 65.86 11.17 148 1481572 3463 109104116
Carotid artery occlusion 65.65 11.17 23 1481697 9542 109098037
Dysphagia 65.61 11.17 1561 1480159 152039 108955540
Metastases to central nervous system 65.42 11.17 129 1481591 22688 109084891
Dust allergy 65.42 11.17 203 1481517 5798 109101781
Anaphylactic reaction 64.89 11.17 1108 1480612 113192 108994387
Blood calcium increased 64.80 11.17 88 1481632 17952 109089627
Complications of transplanted lung 64.70 11.17 62 1481658 635 109106944
Cryptococcal fungaemia 64.65 11.17 44 1481676 261 109107318
Aspiration 64.56 11.17 202 1481518 30331 109077248
Limb deformity 64.42 11.17 150 1481570 3596 109103983
Coma scale abnormal 64.04 11.17 25 1481695 9701 109097878
Muscle twitching 64.04 11.17 197 1481523 29738 109077841
Impaired work ability 63.90 11.17 587 1481133 25832 109081747
Hyperthermia 63.85 11.17 117 1481603 21155 109086424
Monkeypox 63.33 11.17 47 1481673 326 109107253
Ataxia 63.09 11.17 200 1481520 29908 109077671
Blood sodium decreased 63.07 11.17 281 1481439 38038 109069541
Asthenia 63.04 11.17 8177 1473543 680822 108426757
Hyperphosphataemia 62.89 11.17 76 1481644 16305 109091274
Acute generalised exanthematous pustulosis 62.53 11.17 122 1481598 21542 109086037
Bronchial disorder 62.51 11.17 124 1481596 2652 109104927
Bradyphrenia 62.41 11.17 40 1481680 11688 109095891
Mental impairment 62.35 11.17 131 1481589 22508 109085071
Musculoskeletal disorder 62.32 11.17 518 1481202 22146 109085433
Disseminated aspergillosis 62.25 11.17 116 1481604 2364 109105215
Depressed mood 62.17 11.17 518 1481202 60291 109047288
Nodule 62.07 11.17 690 1481030 31941 109075638
Skin ulcer 62.05 11.17 1198 1480522 62447 109045132
Squamous cell carcinoma of skin 61.92 11.17 419 1481301 16784 109090795
Microsporidia infection 61.87 11.17 86 1481634 1353 109106226
Disseminated varicella zoster virus infection 61.85 11.17 81 1481639 1200 109106379
Disseminated mycobacterium avium complex infection 61.69 11.17 53 1481667 465 109107114
Disseminated coccidioidomycosis 61.68 11.17 40 1481680 216 109107363
Hypoglycaemic coma 61.51 11.17 3 1481717 5530 109102049
Pneumoperitoneum 61.49 11.17 153 1481567 3831 109103748
Chest X-ray abnormal 61.46 11.17 251 1481469 8236 109099343
Asthma-chronic obstructive pulmonary disease overlap syndrome 61.36 11.17 206 1481514 6138 109101441
Device issue 61.31 11.17 246 1481474 34289 109073290
Paranoia 61.17 11.17 130 1481590 22244 109085335
Vasogenic cerebral oedema 60.97 11.17 109 1481611 2149 109105430
Drug specific antibody 60.91 11.17 124 1481596 2704 109104875
Faecaloma 60.66 11.17 66 1481654 14842 109092737
Apnoea 60.51 11.17 56 1481664 13583 109093996
Pancreatic carcinoma 60.34 11.17 66 1481654 14806 109092773
Human bocavirus infection 60.26 11.17 75 1481645 1053 109106526
Shock 60.14 11.17 445 1481275 53143 109054436
Joint injury 60.14 11.17 809 1480911 39185 109068394
Eosinophilic bronchitis 59.92 11.17 55 1481665 531 109107048
Granuloma 59.73 11.17 269 1481451 9221 109098358
Complication associated with device 59.72 11.17 111 1481609 19962 109087617
Vision blurred 59.69 11.17 1295 1480425 127727 108979852
Anticoagulant therapy 59.30 11.17 3 1481717 5358 109102221
Skin exfoliation 59.17 11.17 822 1480898 86829 109020750
Malignant fibrous histiocytoma 59.07 11.17 40 1481680 235 109107344
Ventricular extrasystoles 59.06 11.17 135 1481585 22506 109085073
Drug level above therapeutic 58.93 11.17 309 1481411 11279 109096300
Foetal death 58.93 11.17 77 1481643 15968 109091611
Device use error 58.80 11.17 24 1481696 9065 109098514
Vascular pseudoaneurysm ruptured 58.78 11.17 54 1481666 522 109107057
Device occlusion 58.77 11.17 70 1481650 15115 109092464
Presyncope 58.75 11.17 398 1481322 48489 109059090
Pneumonia pseudomonal 58.52 11.17 228 1481492 7318 109100261
Staphylococcal infection 58.47 11.17 1287 1480433 68657 109038922
Biopsy lung abnormal 58.42 11.17 33 1481687 132 109107447
Lower respiratory tract infection 58.32 11.17 3892 1477828 239214 108868365
Diabetic ketoacidosis 58.02 11.17 328 1481392 41730 109065849
Hepatic enzyme increased 57.91 11.17 5023 1476697 315869 108791710
Aphasia 57.89 11.17 508 1481212 58489 109049090
Sinus pain 57.84 11.17 192 1481528 5687 109101892
Ileostomy 57.71 11.17 110 1481610 2282 109105297
Donor specific antibody present 57.65 11.17 46 1481674 360 109107219
Head injury 57.46 11.17 339 1481381 42678 109064901
B-cell lymphoma recurrent 57.12 11.17 74 1481646 1084 109106495
Haematoma 56.72 11.17 505 1481215 57971 109049608
Urinary incontinence 56.69 11.17 399 1481321 48188 109059391
Eosinophil count increased 56.68 11.17 479 1481241 20579 109087000
Calciphylaxis 56.61 11.17 153 1481567 4034 109103545
Blood uric acid increased 56.46 11.17 128 1481592 21401 109086178
Rheumatoid factor positive 56.42 11.17 2228 1479492 129412 108978167
Herpes simplex oesophagitis 56.33 11.17 48 1481672 416 109107163
Pruritus 56.24 11.17 6877 1474843 574683 108532896
Psychomotor hyperactivity 56.12 11.17 117 1481603 20160 109087419
Middle insomnia 56.06 11.17 468 1481252 20034 109087545
Neuroendocrine carcinoma of the skin 56.05 11.17 91 1481629 1654 109105925
Fear 56.00 11.17 144 1481576 23049 109084530
Breast cancer stage I 55.67 11.17 15 1481705 7372 109100207
Hypersensitivity 55.67 11.17 6206 1475514 397792 108709787
Viral infection 55.51 11.17 1011 1480709 52128 109055451
Prothrombin time prolonged 55.40 11.17 91 1481629 17170 109090409
Wrong patient received product 55.37 11.17 11 1481709 6663 109100916
Human herpesvirus 6 infection 55.29 11.17 204 1481516 6377 109101202
Kidney infection 55.11 11.17 555 1481165 25044 109082535
Irritability 55.10 11.17 394 1481326 47415 109060164
Bronchial obstruction 54.83 11.17 125 1481595 2954 109104625
Hypertonia 54.70 11.17 22 1481698 8384 109099195
Mass 54.70 11.17 450 1481270 19180 109088399
Sleep terror 54.62 11.17 11 1481709 6599 109100980
Impaired healing 54.50 11.17 3189 1478531 193528 108914051
Hepatitis E 54.44 11.17 157 1481563 4302 109103277
Joint effusion 54.42 11.17 472 1481248 20433 109087146
Graft versus host disease in lung 54.39 11.17 76 1481644 1202 109106377
Periostitis 54.37 11.17 61 1481659 762 109106817
Thrombotic microangiopathy 54.36 11.17 614 1481106 28535 109079044
Hyperprolactinaemia 54.21 11.17 11 1481709 6564 109101015
Obsessive-compulsive disorder 54.02 11.17 15 1481705 7226 109100353
Chest pain 53.88 11.17 4325 1477395 372050 108735529
Mental status changes 53.87 11.17 707 1481013 75415 109032164
Cutaneous nocardiosis 53.84 11.17 40 1481680 278 109107301
Psychomotor skills impaired 53.83 11.17 14 1481706 7044 109100535
Sleep disorder due to general medical condition, insomnia type 53.79 11.17 1823 1479897 103820 109003759
Alopecia 53.71 11.17 5628 1476092 359125 108748454
Epstein-Barr virus test positive 53.69 11.17 77 1481643 1249 109106330
Vaginal haemorrhage 53.64 11.17 165 1481555 24909 109082670
Opportunistic infection 53.57 11.17 135 1481585 3408 109104171
Clonus 53.25 11.17 25 1481695 8691 109098888
Electrolyte imbalance 53.15 11.17 285 1481435 36743 109070836
Skin fissures 53.00 11.17 160 1481560 24298 109083281
Joint stiffness 52.98 11.17 1227 1480493 66016 109041563
Femoral neck fracture 52.97 11.17 54 1481666 12513 109095066
Rash erythematous 52.92 11.17 774 1480946 81058 109026521
Oesophageal candidiasis 52.89 11.17 299 1481421 11235 109096344
Systemic mycosis 52.86 11.17 141 1481579 3688 109103891
Speech disorder 52.81 11.17 548 1481172 61021 109046558
Mucocutaneous leishmaniasis 52.67 11.17 49 1481671 482 109107097
Secretion discharge 52.66 11.17 457 1481263 19787 109087792
Long QT syndrome 52.63 11.17 15 1481705 7103 109100476
Cryptococcal cutaneous infection 52.39 11.17 39 1481681 272 109107307
Disseminated mucormycosis 52.37 11.17 98 1481622 2004 109105575
Drug screen positive 52.28 11.17 11 1481709 6399 109101180
Hepatic encephalopathy 52.26 11.17 198 1481522 28058 109079521
Atrial tachycardia 52.08 11.17 29 1481691 9149 109098430
Polyp 52.05 11.17 268 1481452 9712 109097867
Animal scratch 51.82 11.17 91 1481629 1768 109105811
Appendicitis 51.65 11.17 201 1481519 28263 109079316
Anxiety 51.62 11.17 3951 1477769 341127 108766452
Angina unstable 51.47 11.17 88 1481632 16344 109091235
Atrioventricular block 51.40 11.17 92 1481628 16785 109090794
Herpes simplex hepatitis 51.31 11.17 58 1481662 731 109106848
Tachypnoea 51.28 11.17 313 1481407 39082 109068497
Mycobacterium fortuitum infection 51.26 11.17 47 1481673 453 109107126
Papilloma viral infection 51.18 11.17 98 1481622 2040 109105539
Pneumonia necrotising 50.92 11.17 88 1481632 1687 109105892
Polyarthritis 50.86 11.17 431 1481289 18532 109089047
Pancreatitis acute 50.67 11.17 539 1481181 59735 109047844
Incorrect route of product administration 50.62 11.17 581 1481139 63480 109044099
Atrioventricular block complete 50.58 11.17 122 1481598 19960 109087619
Exposure via ingestion 50.46 11.17 4 1481716 4896 109102683
Abnormal dreams 50.45 11.17 58 1481662 12722 109094857
Hypertensive crisis 50.30 11.17 163 1481557 24209 109083370
Metastatic squamous cell carcinoma 50.19 11.17 56 1481664 695 109106884
Dry mouth 50.16 11.17 2178 1479542 197770 108909809
Thirst 49.97 11.17 138 1481582 21569 109086010
Psychomotor retardation 49.73 11.17 21 1481699 7771 109099808
Pruritus genital 49.62 11.17 13 1481707 6509 109101070
Vital capacity decreased 49.60 11.17 95 1481625 1978 109105601
Angiocentric lymphoma 49.45 11.17 72 1481648 1185 109106394
Bronchial secretion retention 49.36 11.17 164 1481556 4860 109102719
Blood potassium increased 49.36 11.17 253 1481467 32996 109074583
Haematuria 49.29 11.17 798 1480922 82207 109025372
Troponin increased 49.15 11.17 218 1481502 29548 109078031
Hiccups 49.09 11.17 60 1481660 12809 109094770
Cardiac failure chronic 48.98 11.17 68 1481652 13743 109093836
Cytopenia 48.97 11.17 618 1481102 29498 109078081
Heart rate irregular 48.97 11.17 687 1481033 33587 109073992
Cytomegalovirus syndrome 48.89 11.17 38 1481682 285 109107294
Pneumonia legionella 48.84 11.17 131 1481589 3438 109104141
Glycosylated haemoglobin increased 48.72 11.17 158 1481562 23461 109084118
Mouth ulceration 48.60 11.17 911 1480809 47227 109060352
Transplant failure 48.46 11.17 176 1481544 5459 109102120
Mycobacterium abscessus infection 48.19 11.17 84 1481636 1622 109105957
Necrotising oesophagitis 48.11 11.17 81 1481639 1519 109106060
Adrenal insufficiency 48.03 11.17 817 1480903 41573 109066006
Body height below normal 48.03 11.17 94 1481626 1990 109105589
Product quality issue 47.97 11.17 737 1480983 76562 109031017
Hepatocellular injury 47.96 11.17 440 1481280 50202 109057377
Priapism 47.92 11.17 10 1481710 5851 109101728
T-cell lymphoma 47.68 11.17 80 1481640 1496 109106083
Acarodermatitis 47.67 11.17 91 1481629 1890 109105689
Immune-mediated hepatic disorder 47.66 11.17 3 1481717 4447 109103132
Pericarditis fungal 47.65 11.17 37 1481683 277 109107302
Osteomyelitis fungal 47.62 11.17 42 1481678 383 109107196
Dermatitis acneiform 47.58 11.17 60 1481660 12635 109094944
Syringe issue 47.34 11.17 35 1481685 9490 109098089
Heparin-induced thrombocytopenia 47.13 11.17 50 1481670 11374 109096205
Petit mal epilepsy 47.11 11.17 21 1481699 7526 109100053
Squamous cell carcinoma 47.10 11.17 415 1481305 18048 109089531
Salmonellosis 47.08 11.17 97 1481623 2134 109105445
Human antichimeric antibody positive 46.92 11.17 84 1481636 1658 109105921
Psoriatic arthropathy 46.82 11.17 3148 1478572 193613 108913966
Upper respiratory tract inflammation 46.65 11.17 3 1481717 4368 109103211
Breast cancer female 46.65 11.17 59 1481661 12409 109095170
Accidental death 46.63 11.17 6 1481714 5003 109102576
Palmoplantar keratoderma 46.58 11.17 8 1481712 5379 109102200
C-reactive protein abnormal 46.57 11.17 2155 1479565 127540 108980039
Somnambulism 46.43 11.17 14 1481706 6391 109101188
Scleritis 46.37 11.17 169 1481551 5251 109102328
Cutaneous mucormycosis 46.34 11.17 53 1481667 677 109106902
Mycotic allergy 46.25 11.17 180 1481540 5774 109101805
Drug use disorder 46.16 11.17 109 1481611 17965 109089614
Eosinophil count abnormal 45.90 11.17 64 1481656 1010 109106569
Pneumatosis intestinalis 45.86 11.17 231 1481489 8298 109099281
Immunosuppressant drug level decreased 45.52 11.17 109 1481611 2662 109104917
Anticholinergic syndrome 45.50 11.17 3 1481717 4277 109103302
Ammonia increased 45.48 11.17 27 1481693 8223 109099356
Upper respiratory fungal infection 45.47 11.17 41 1481679 386 109107193
Bloody discharge 45.43 11.17 108 1481612 2625 109104954
Angina pectoris 45.40 11.17 575 1481145 61720 109045859
Osteopenia 45.19 11.17 476 1481244 21733 109085846
Cytomegalovirus infection reactivation 45.18 11.17 409 1481311 17924 109089655
Acute pulmonary histoplasmosis 45.08 11.17 35 1481685 262 109107317
Amylase increased 45.04 11.17 61 1481659 12458 109095121
Application site erythema 45.00 11.17 10 1481710 5600 109101979
Mobility decreased 44.95 11.17 3730 1477990 233692 108873887
Breast cancer metastatic 44.94 11.17 50 1481670 11131 109096448
Meningitis listeria 44.91 11.17 70 1481650 1227 109106352
Endocarditis bacterial 44.78 11.17 84 1481636 1721 109105858
Infective scleritis 44.63 11.17 25 1481695 98 109107481
Diffuse large B-cell lymphoma refractory 44.51 11.17 102 1481618 2419 109105160
Renal tubular injury 44.48 11.17 116 1481604 2992 109104587
Steroid withdrawal syndrome 44.46 11.17 59 1481661 886 109106693
Personality change 44.44 11.17 49 1481671 10953 109096626
Nodular regenerative hyperplasia 44.38 11.17 79 1481641 1552 109106027
Deformity 44.38 11.17 260 1481460 9900 109097679
Penicillium infection 44.29 11.17 49 1481671 602 109106977
Sputum purulent 44.22 11.17 86 1481634 1812 109105767
Lower respiratory tract congestion 43.99 11.17 153 1481567 4643 109102936
Haemoglobin decreased 43.90 11.17 2807 1478913 245920 108861659
Empyema 43.77 11.17 169 1481551 5401 109102178
Bone density decreased 43.76 11.17 366 1481354 15676 109091903
Pneumonia 43.62 11.17 12769 1468951 863945 108243634
Necrotising herpetic retinopathy 43.41 11.17 29 1481691 166 109107413
Symptom masked 43.10 11.17 85 1481635 1810 109105769
Peak expiratory flow rate decreased 43.06 11.17 50 1481670 650 109106929
Hepatosplenic T-cell lymphoma 43.03 11.17 60 1481660 947 109106632
Large intestinal ulcer 43.01 11.17 172 1481548 5589 109101990
Transfusion 43.01 11.17 185 1481535 25287 109082292
Face oedema 43.00 11.17 267 1481453 33202 109074377
Right ventricular failure 42.91 11.17 190 1481530 25764 109081815
Uterine perforation 42.75 11.17 19 1481701 6821 109100758
Mycobacterium marinum infection 42.70 11.17 52 1481668 713 109106866
Sickle cell anaemia with crisis 42.57 11.17 39 1481681 9506 109098073
Genital haemorrhage 42.49 11.17 22 1481698 7230 109100349
Body temperature fluctuation 42.40 11.17 129 1481591 3644 109103935
Enterovirus infection 42.36 11.17 106 1481614 2664 109104915
Diplopia 42.32 11.17 358 1481362 41536 109066043
Bowel movement irregularity 42.27 11.17 209 1481511 7451 109100128
Cerebral haematoma 42.20 11.17 40 1481680 9592 109097987
Erythema nodosum 42.19 11.17 189 1481531 6464 109101115
Orf 42.14 11.17 20 1481700 50 109107529
Atrioventricular block second degree 42.06 11.17 29 1481691 8152 109099427
On and off phenomenon 41.91 11.17 5 1481715 4419 109103160
Pulmonary fibrosis 41.86 11.17 1719 1480001 100323 109007256
Rheumatoid lung 41.84 11.17 140 1481580 4164 109103415
Inflammatory bowel disease 41.81 11.17 200 1481520 7034 109100545
Neutropenic sepsis 41.76 11.17 241 1481479 30505 109077074
Glomerulonephritis 41.76 11.17 149 1481571 4581 109102998
Pseudohyponatraemia 41.72 11.17 29 1481691 179 109107400
Skin plaque 41.42 11.17 301 1481419 12344 109095235
Abdominal abscess 41.35 11.17 230 1481490 8589 109098990
Histoplasmosis cutaneous 41.34 11.17 21 1481699 64 109107515
Granuloma skin 41.32 11.17 276 1481444 11007 109096572
Vertigo 41.32 11.17 868 1480852 86002 109021577
Kaposi's sarcoma 41.28 11.17 49 1481671 653 109106926
Galactorrhoea 41.14 11.17 4 1481716 4151 109103428
Kounis syndrome 41.09 11.17 14 1481706 5911 109101668
Cytomegalovirus oesophagitis 41.02 11.17 58 1481662 928 109106651
Chronic kidney disease 40.93 11.17 747 1480973 75544 109032035
Blood parathyroid hormone decreased 40.84 11.17 308 1481412 12781 109094798
Granulocytopenia 40.84 11.17 67 1481653 12648 109094931
Skin mass 40.83 11.17 248 1481472 9568 109098011
Exposure to SARS-CoV-2 40.81 11.17 108 1481612 2811 109104768
Photodermatosis 40.77 11.17 61 1481659 1030 109106549
Respiratory acidosis 40.65 11.17 77 1481643 13749 109093830
Pulmonary hypertension 40.51 11.17 509 1481211 54711 109052868
Ovarian hyperstimulation syndrome 40.18 11.17 11 1481709 5349 109102230
Tenosynovitis 39.99 11.17 363 1481357 15920 109091659
Colitis 39.99 11.17 1715 1480005 100608 109006971
Dialysis 39.94 11.17 132 1481588 19487 109088092
Polyuria 39.92 11.17 114 1481606 17624 109089955
Bezoar 39.88 11.17 4 1481716 4050 109103529
Bone disorder 39.80 11.17 447 1481273 20745 109086834
Tension headache 39.78 11.17 42 1481678 9576 109098003
Renal cancer 39.74 11.17 71 1481649 12963 109094616
Unintended pregnancy 39.73 11.17 8 1481712 4800 109102779
Perinephric abscess 39.67 11.17 38 1481682 389 109107190
Chromoblastomycosis 39.59 11.17 26 1481694 144 109107435
Cholelithiasis 39.59 11.17 604 1481116 62818 109044761
Injection site pain 39.42 11.17 1964 1479756 175958 108931621
Bradykinesia 39.38 11.17 52 1481668 10736 109096843
Blood thyroid stimulating hormone increased 39.34 11.17 65 1481655 12236 109095343
Total lung capacity increased 39.27 11.17 154 1481566 4958 109102621
Trichophytosis 39.26 11.17 40 1481680 444 109107135
Hypophagia 39.01 11.17 484 1481236 52142 109055437
Immune system disorder 38.97 11.17 312 1481408 13189 109094390
Disseminated cytomegaloviral infection 38.87 11.17 45 1481675 583 109106996
Norovirus test positive 38.80 11.17 56 1481664 914 109106665
Pulse absent 38.66 11.17 57 1481663 11235 109096344
Cutaneous malacoplakia 38.63 11.17 26 1481694 151 109107428
Central nervous system vasculitis 38.60 11.17 75 1481645 1579 109106000
Skin graft rejection 38.53 11.17 21 1481699 77 109107502
Atypical mycobacterial infection 38.45 11.17 101 1481619 2617 109104962
Metastases to bone 38.40 11.17 254 1481466 31118 109076461
Malacoplakia gastrointestinal 38.18 11.17 30 1481690 229 109107350
Mood altered 38.11 11.17 152 1481568 21223 109086356
Scleroderma renal crisis 37.96 11.17 54 1481666 869 109106710
Tuberculosis gastrointestinal 37.89 11.17 44 1481676 572 109107007
Pancreas transplant rejection 37.88 11.17 35 1481685 341 109107238
Anhedonia 37.86 11.17 95 1481625 15333 109092246
Chromaturia 37.84 11.17 234 1481486 29126 109078453
Cold sweat 37.82 11.17 159 1481561 21872 109085707
Cutaneous blastomycosis 37.80 11.17 20 1481700 68 109107511
Device malfunction 37.64 11.17 195 1481525 25363 109082216
Clear cell renal cell carcinoma 37.55 11.17 101 1481619 2655 109104924
Stress cardiomyopathy 37.50 11.17 99 1481621 15707 109091872
Lymphopenia 37.43 11.17 751 1480969 39419 109068160
Sinusitis fungal 37.39 11.17 100 1481620 2620 109104959
Erythema 37.36 11.17 3378 1478342 288069 108819510
Eructation 37.33 11.17 83 1481637 13974 109093605
Hyperlipidaemia 37.27 11.17 304 1481416 35544 109072035
Plasmablastic lymphoma 37.23 11.17 50 1481670 760 109106819
Systemic infection 37.22 11.17 46 1481674 9773 109097806
Ileus 37.01 11.17 250 1481470 30479 109077100
Paronychia 36.90 11.17 57 1481663 11024 109096555
Superinfection bacterial 36.84 11.17 92 1481628 2309 109105270
Ankylosing spondylitis 36.81 11.17 345 1481375 15267 109092312
Alveolar osteitis 36.79 11.17 58 1481662 1027 109106552
Behaviour disorder 36.78 11.17 45 1481675 9602 109097977
Vascular hyalinosis 36.77 11.17 25 1481695 148 109107431
Emphysematous pyelonephritis 36.76 11.17 42 1481678 536 109107043
Body temperature increased 36.73 11.17 977 1480743 53736 109053843
Systemic lupus erythematosus rash 36.66 11.17 83 1481637 1952 109105627
Nephropathy toxic 36.57 11.17 544 1481176 26934 109080645
Skin necrosis 36.51 11.17 445 1481275 21067 109086512
Polycystic ovaries 36.45 11.17 144 1481576 4652 109102927
Lymphoma 36.32 11.17 422 1481298 19749 109087830
Toxic encephalopathy 36.32 11.17 95 1481625 15119 109092460
Ejection fraction decreased 36.24 11.17 361 1481359 40519 109067060
Eye abscess 35.96 11.17 34 1481686 342 109107237
Infective tenosynovitis 35.95 11.17 39 1481681 468 109107111
Swollen tongue 35.94 11.17 580 1481140 59782 109047797
B-cell lymphoma 35.86 11.17 190 1481530 6964 109100615
Thinking abnormal 35.79 11.17 95 1481625 15045 109092534
Abdominal pain upper 35.76 11.17 4112 1477608 344999 108762580
Lymphoproliferative disorder 35.70 11.17 191 1481529 7027 109100552
Ventricular remodelling 35.64 11.17 23 1481697 123 109107456
Sinus congestion 35.59 11.17 590 1481130 29869 109077710
Blood loss anaemia 35.52 11.17 123 1481597 17902 109089677
Aplastic anaemia 35.50 11.17 186 1481534 24122 109083457
Reversible airways obstruction 35.49 11.17 93 1481627 2406 109105173
Diabetes mellitus inadequate control 35.48 11.17 243 1481477 29532 109078047
Subdural haemorrhage 35.40 11.17 22 1481698 6536 109101043
Tuberculin test positive 35.38 11.17 119 1481601 3549 109104030
Hypothyroidism 35.38 11.17 726 1480994 72173 109035406
Gastric cancer 35.36 11.17 58 1481662 10950 109096629
Glomerulonephritis membranoproliferative 35.36 11.17 50 1481670 800 109106779
Nystagmus 35.35 11.17 63 1481657 11514 109096065
Meningitis enterococcal 35.30 11.17 26 1481694 178 109107401
Lymphocyte count decreased 35.10 11.17 547 1481173 56696 109050883
Toxic anterior segment syndrome 35.07 11.17 3 1481717 3451 109104128
Tumour marker increased 35.02 11.17 12 1481708 5048 109102531
Wrong product administered 34.97 11.17 58 1481662 10902 109096677
Dermatophytosis 34.96 11.17 41 1481679 539 109107040
Lymph node calcification 34.88 11.17 37 1481683 432 109107147
Organising pneumonia 34.72 11.17 317 1481403 13926 109093653
Foot deformity 34.67 11.17 873 1480847 47607 109059972
Illness 34.56 11.17 1388 1480332 80783 109026796
Lung abscess 34.54 11.17 146 1481574 4866 109102713
Incorrect product administration duration 34.53 11.17 149 1481571 20349 109087230
Helicobacter infection 34.52 11.17 2858 1478862 179019 108928560
Arthrodesis 34.45 11.17 97 1481623 2621 109104958
Herpes zoster cutaneous disseminated 34.35 11.17 39 1481681 494 109107085
Sensory disturbance 34.30 11.17 119 1481601 17310 109090269
Colorectal cancer 34.23 11.17 43 1481677 9071 109098508
Solar lentigo 34.23 11.17 68 1481652 1456 109106123
Treatment noncompliance 34.22 11.17 731 1480989 72259 109035320
Complications of transplant surgery 34.16 11.17 47 1481673 732 109106847
Chest discomfort 34.15 11.17 2739 1478981 171109 108936470
Hypotonia 34.12 11.17 103 1481617 15642 109091937
Chorioretinitis 34.05 11.17 65 1481655 1350 109106229
Synovial cyst 34.01 11.17 266 1481454 11164 109096415
Disability assessment scale score increased 33.92 11.17 130 1481590 4140 109103439
Prostatic specific antigen increased 33.90 11.17 285 1481435 12226 109095353
Herpes virus infection 33.90 11.17 215 1481505 8423 109099156
Loose body in joint 33.89 11.17 65 1481655 1355 109106224
Stenotrophomonas infection 33.88 11.17 162 1481558 5696 109101883
Myasthenia gravis crisis 33.82 11.17 75 1481645 1739 109105840
Rhinovirus infection 33.79 11.17 272 1481448 11517 109096062
Herpes simplex colitis 33.78 11.17 21 1481699 104 109107475
Pulmonary embolism 33.75 11.17 2445 1479275 212029 108895550
SARS-CoV-2 RNA increased 33.73 11.17 25 1481695 173 109107406
Bordetella infection 33.67 11.17 27 1481693 213 109107366
Prescribed overdose 33.64 11.17 904 1480816 86677 109020902
Purulent pericarditis 33.63 11.17 21 1481699 105 109107474
Bone swelling 33.62 11.17 75 1481645 1746 109105833
Hypertrophic cardiomyopathy 33.56 11.17 106 1481614 3057 109104522
Coagulopathy 33.52 11.17 368 1481352 40543 109067036
Cholecystitis chronic 33.46 11.17 47 1481673 9453 109098126
Lymphadenitis 33.30 11.17 154 1481566 5339 109102240
Pneumonia fungal 33.28 11.17 323 1481397 14431 109093148
Tearfulness 33.24 11.17 30 1481690 7365 109100214
Blood immunoglobulin M decreased 33.22 11.17 80 1481640 1961 109105618
Obstruction 33.22 11.17 159 1481561 5593 109101986
Cystitis bacterial 33.21 11.17 60 1481660 1193 109106386
Latent tuberculosis 33.18 11.17 123 1481597 3854 109103725
Interstitial lung disease 33.10 11.17 2229 1479491 137105 108970474
Pleural effusion 33.01 11.17 1996 1479724 175713 108931866
Faeces discoloured 33.00 11.17 293 1481427 33655 109073924
Bronchial polyp 32.90 11.17 19 1481701 80 109107499
Frustration tolerance decreased 32.84 11.17 215 1481505 8516 109099063
Cerebral fungal infection 32.66 11.17 44 1481676 671 109106908
Trench fever 32.66 11.17 16 1481704 44 109107535
Coombs positive haemolytic anaemia 32.61 11.17 68 1481652 1509 109106070
Pulmonary arterial hypertension 32.58 11.17 279 1481441 32289 109075290
Lung disorder 32.55 11.17 2819 1478901 177228 108930351
Fat embolism syndrome 32.52 11.17 22 1481698 129 109107450
Incontinence 32.46 11.17 114 1481606 16521 109091058
Cross sensitivity reaction 32.45 11.17 17 1481703 5550 109102029
Red blood cell count decreased 32.44 11.17 655 1481065 65268 109042311
Basal cell carcinoma 32.32 11.17 815 1480905 44455 109063124
Right atrial hypertrophy 32.29 11.17 43 1481677 648 109106931
Mitral valve incompetence 32.25 11.17 288 1481432 33041 109074538
Duodenal ulcer perforation 32.25 11.17 2783 1478937 174917 108932662
Campylobacter infection 32.23 11.17 87 1481633 2292 109105287
Rhonchi 32.23 11.17 133 1481587 4385 109103194
Contrast media allergy 32.10 11.17 110 1481610 3313 109104266
Pyomyositis 32.05 11.17 45 1481675 715 109106864
Drooling 32.04 11.17 29 1481691 7110 109100469
Osteomyelitis 32.04 11.17 678 1481042 35922 109071657
Pre-engraftment immune reaction 32.01 11.17 35 1481685 424 109107155
Faecal calprotectin abnormal 31.94 11.17 31 1481689 323 109107256
Abscess limb 31.81 11.17 209 1481511 8288 109099291
Pneumonia klebsiella 31.79 11.17 174 1481546 6458 109101121
Oesophageal ulcer 31.73 11.17 199 1481521 7765 109099814
Multifocal micronodular pneumocyte hyperplasia 31.68 11.17 18 1481702 73 109107506
Dermatomyositis 31.66 11.17 130 1481590 4276 109103303
Serum sickness 31.66 11.17 130 1481590 4276 109103303
Product preparation error 31.63 11.17 61 1481659 10818 109096761
Cutaneous sporotrichosis 31.49 11.17 18 1481702 74 109107505
Haemorrhagic stroke 31.49 11.17 88 1481632 13701 109093878
Multiple sclerosis 31.48 11.17 208 1481512 25490 109082089
Maternal exposure during delivery 31.48 11.17 5 1481715 3560 109104019
Oesophageal stenosis 31.46 11.17 145 1481575 5020 109102559
Gastrointestinal inflammation 31.36 11.17 226 1481494 9243 109098336
Pyoderma gangrenosum 31.36 11.17 151 1481569 5325 109102254
Urinary tract discomfort 31.33 11.17 51 1481669 929 109106650
Wrist deformity 31.24 11.17 104 1481616 3085 109104494
Respiratory rate increased 31.23 11.17 491 1481229 24592 109082987
Lymphocele 31.17 11.17 74 1481646 1797 109105782
Ischaemic stroke 31.15 11.17 378 1481342 40885 109066694
Central nervous system fungal infection 31.13 11.17 40 1481680 581 109106998
Visual impairment 31.13 11.17 1477 1480243 132951 108974628
Ankle deformity 31.10 11.17 43 1481677 673 109106906
Apparent mineralocorticoid excess 31.06 11.17 17 1481703 63 109107516
Cryopyrin associated periodic syndrome 30.92 11.17 40 1481680 585 109106994
Neurosarcoidosis 30.91 11.17 35 1481685 442 109107137
Taste disorder 30.90 11.17 654 1481066 64733 109042846
Ear pain 30.88 11.17 933 1480787 52293 109055286
Chronic graft versus host disease in skin 30.81 11.17 91 1481629 2528 109105051
Forced vital capacity decreased 30.77 11.17 76 1481644 1894 109105685
Human herpes virus 8 test positive 30.76 11.17 16 1481704 52 109107527
Sinus node dysfunction 30.65 11.17 46 1481674 9001 109098578
Antineutrophil cytoplasmic antibody positive 30.55 11.17 142 1481578 4934 109102645
Coronary artery stenosis 30.54 11.17 89 1481631 13669 109093910
Akinesia 30.52 11.17 6 1481714 3661 109103918
Central nervous system infection 30.49 11.17 70 1481650 1662 109105917
Blood prolactin increased 30.45 11.17 12 1481708 4630 109102949
Hyperreflexia 30.45 11.17 50 1481670 9435 109098144
Tractional retinal detachment 30.42 11.17 20 1481700 111 109107468
Ejection fraction 30.41 11.17 98 1481622 2857 109104722
Social avoidant behaviour 30.41 11.17 17 1481703 5352 109102227
Trichosporon infection 30.40 11.17 59 1481661 1241 109106338
Infectious pleural effusion 30.31 11.17 138 1481582 4753 109102826
Tinnitus 30.25 11.17 600 1481120 59940 109047639
Complication of device removal 30.21 11.17 12 1481708 4608 109102971
Hyperlactacidaemia 30.19 11.17 40 1481680 8246 109099333
Haematocrit decreased 30.17 11.17 665 1481055 65452 109042127
Arthritis infective 30.10 11.17 241 1481479 10188 109097391
Cytomegalovirus nephritis 30.06 11.17 22 1481698 149 109107430
Glaucoma 30.05 11.17 446 1481274 22071 109085508
Creatinine renal clearance increased 30.02 11.17 6 1481714 3619 109103960
Tooth infection 30.02 11.17 441 1481279 21775 109085804
Ophthalmic herpes zoster 30.02 11.17 107 1481613 3288 109104291
Night sweats 30.00 11.17 2133 1479587 131850 108975729
Lyme disease 29.96 11.17 126 1481594 4190 109103389
Substance-induced psychotic disorder 29.94 11.17 148 1481572 5276 109102303
Disseminated sporotrichosis 29.90 11.17 16 1481704 56 109107523
Sinusitis bacterial 29.79 11.17 86 1481634 2358 109105221
Dermatitis bullous 29.78 11.17 127 1481593 17402 109090177
Ileal stenosis 29.72 11.17 104 1481616 3166 109104413
Angiosarcoma metastatic 29.64 11.17 23 1481697 172 109107407
Meningitis histoplasma 29.63 11.17 13 1481707 25 109107554
Bronchitis 29.54 11.17 2466 1479254 154566 108953013
Nephrectomy 29.42 11.17 90 1481630 2550 109105029
Cryptococcal meningoencephalitis 29.42 11.17 31 1481689 359 109107220
Hyperaesthesia 29.36 11.17 100 1481620 14627 109092952
Glomerulonephritis proliferative 29.34 11.17 35 1481685 469 109107110
Diabetic retinopathy 29.31 11.17 6 1481714 3558 109104021
Liver disorder 29.25 11.17 1582 1480138 140661 108966918
Choroiditis 29.24 11.17 66 1481654 1549 109106030
Hypoxia 29.20 11.17 1427 1480293 128088 108979491
Intestinal perforation 29.19 11.17 418 1481302 20526 109087053
Chorioretinopathy 29.18 11.17 82 1481638 2213 109105366
Device breakage 29.18 11.17 91 1481629 13678 109093901
Bundle branch block right 29.15 11.17 77 1481643 12214 109095365
Encephalitis 29.12 11.17 383 1481337 18456 109089123
Gastroenteritis cryptosporidial 29.04 11.17 30 1481690 339 109107240
Abscess bacterial 28.93 11.17 48 1481672 889 109106690
Product administration interrupted 28.92 11.17 68 1481652 11224 109096355
Muscle injury 28.89 11.17 2226 1479494 138581 108968998
Blood glucose decreased 28.89 11.17 254 1481466 29234 109078345
Herpes simplex reactivation 28.85 11.17 62 1481658 1406 109106173
Eye movement disorder 28.76 11.17 54 1481666 9674 109097905
Oxalosis 28.70 11.17 20 1481700 124 109107455
Ulcer 28.68 11.17 769 1480951 42347 109065232
Product dispensing error 28.66 11.17 117 1481603 16228 109091351
Perfume sensitivity 28.61 11.17 52 1481668 1039 109106540
Pulmonary cavitation 28.50 11.17 79 1481641 2115 109105464
Tic 28.48 11.17 6 1481714 3487 109104092
Vascular device infection 28.45 11.17 119 1481601 16393 109091186
Limb mass 28.44 11.17 117 1481603 3852 109103727
Cholangitis sclerosing 28.41 11.17 109 1481611 3473 109104106
Abdominal distension 28.39 11.17 1991 1479729 173112 108934467
Wrist surgery 28.37 11.17 46 1481674 835 109106744
Vasoplegia syndrome 28.33 11.17 19 1481701 5420 109102159
Medial tibial stress syndrome 28.33 11.17 23 1481697 185 109107394
Mite allergy 28.32 11.17 153 1481567 5650 109101929
Hyperthyroidism 28.24 11.17 253 1481467 29008 109078571
Irritable bowel syndrome 28.13 11.17 2561 1479159 161654 108945925
Metastatic malignant melanoma 28.08 11.17 105 1481615 3304 109104275
Periorbital oedema 28.05 11.17 59 1481661 10133 109097446
Giant cell arteritis 28.04 11.17 112 1481608 3637 109103942
Drug abuser 28.04 11.17 19 1481701 5390 109102189
Transitional cell carcinoma 28.01 11.17 100 1481620 3075 109104504
Haemorrhage subcutaneous 27.99 11.17 20 1481700 5519 109102060
Cholangitis 27.97 11.17 118 1481602 16217 109091362
Skin squamous cell carcinoma recurrent 27.93 11.17 18 1481702 96 109107483
Anal fistula 27.93 11.17 202 1481518 8271 109099308
Q fever 27.92 11.17 27 1481693 280 109107299
Abortion incomplete 27.84 11.17 4 1481716 3068 109104511
Anaesthetic complication 27.79 11.17 7 1481713 3599 109103980
Renal transplant 27.73 11.17 101 1481619 3137 109104442
Cell-mediated immune deficiency 27.72 11.17 24 1481696 213 109107366
Elbow deformity 27.67 11.17 62 1481658 1448 109106131
Lipodystrophy acquired 27.60 11.17 13 1481707 4511 109103068
Colitis ischaemic 27.53 11.17 133 1481587 17617 109089962
Pregnancy with contraceptive device 27.50 11.17 9 1481711 3898 109103681
Central nervous system abscess 27.49 11.17 14 1481706 43 109107536
Maternal exposure during pregnancy 27.39 11.17 3856 1477864 251027 108856552
Diabetic neuropathy 27.37 11.17 32 1481688 6967 109100612
Left ventricular dysfunction 27.37 11.17 193 1481527 23300 109084279
Acute coronary syndrome 27.35 11.17 189 1481531 22923 109084656
Cutaneous leishmaniasis 27.34 11.17 30 1481690 365 109107214
Ventricular arrhythmia 27.25 11.17 59 1481661 10028 109097551
Post procedural haemorrhage 27.22 11.17 111 1481609 15401 109092178
Carpal tunnel syndrome 27.17 11.17 440 1481280 22170 109085409
C3 glomerulopathy 27.17 11.17 21 1481699 156 109107423
Embedded device 27.17 11.17 10 1481710 4023 109103556
Pain in extremity 26.93 11.17 7127 1474593 479991 108627588
Dysuria 26.86 11.17 608 1481112 59623 109047956
Mental disorder 26.82 11.17 362 1481358 38429 109069150
Skin squamous cell carcinoma metastatic 26.77 11.17 17 1481703 88 109107491
Bacteraemia 26.77 11.17 751 1480969 41639 109065940
Ocular hypertension 26.75 11.17 82 1481638 2326 109105253
Metastases to lung 26.61 11.17 190 1481530 22873 109084706
Giant cell myocarditis 26.59 11.17 14 1481706 47 109107532
Abscess intestinal 26.58 11.17 101 1481619 3203 109104376
Sarcoma of skin 26.57 11.17 16 1481704 74 109107505
Skin burning sensation 26.56 11.17 177 1481543 21648 109085931
Feeling abnormal 26.54 11.17 2072 1479648 178639 108928940
Respiratory tract inflammation 26.45 11.17 49 1481671 994 109106585
Malignant melanoma 26.36 11.17 344 1481376 16547 109091032
Urine output decreased 26.35 11.17 157 1481563 19719 109087860
Needle issue 26.34 11.17 136 1481584 17704 109089875
Pseudomembranous colitis 26.33 11.17 28 1481692 6363 109101216
Acidosis 26.30 11.17 185 1481535 22346 109085233
Logorrhoea 26.25 11.17 17 1481703 4940 109102639
Emphysema 26.24 11.17 391 1481329 19365 109088214
Pruritus allergic 26.24 11.17 65 1481655 1623 109105956
Respiratory symptom 26.17 11.17 311 1481409 14634 109092945
Disseminated varicella zoster vaccine virus infection 26.15 11.17 20 1481700 146 109107433
Malignant transformation 26.15 11.17 61 1481659 1464 109106115
Inadequate analgesia 26.09 11.17 18 1481702 5059 109102520
Aeromonas infection 26.00 11.17 34 1481686 503 109107076
Tuberculosis of central nervous system 26.00 11.17 34 1481686 503 109107076
Gastritis 25.99 11.17 535 1481185 53164 109054415
Eye infection syphilitic 25.99 11.17 10 1481710 11 109107568
Oesophageal carcinoma 25.98 11.17 74 1481646 11450 109096129
Glomerular filtration rate decreased 25.96 11.17 255 1481465 28701 109078878
Hallucinations, mixed 25.92 11.17 48 1481672 8645 109098934
Cardiomegaly 25.92 11.17 257 1481463 28873 109078706
Allergy to animal 25.89 11.17 70 1481650 1846 109105733
Viral vasculitis 25.89 11.17 23 1481697 212 109107367
Sepsis 25.86 11.17 3919 1477801 323427 108784152
Yersinia infection 25.78 11.17 18 1481702 112 109107467
Intermenstrual bleeding 25.75 11.17 33 1481687 6901 109100678
Endophthalmitis 25.74 11.17 193 1481527 7994 109099585
Graft ischaemia 25.69 11.17 19 1481701 131 109107448
Product physical issue 25.69 11.17 18 1481702 5018 109102561
Haemorrhage intracranial 25.60 11.17 256 1481464 28713 109078866
Rectal abscess 25.60 11.17 87 1481633 2609 109104970
Spirometry abnormal 25.53 11.17 143 1481577 5354 109102225
Oxygen saturation decreased 25.51 11.17 2439 1479281 154543 108953036
Tumour lysis syndrome 25.50 11.17 566 1481154 30235 109077344
Immune-mediated hypothyroidism 25.46 11.17 4 1481716 2871 109104708
Post procedural discharge 25.42 11.17 41 1481679 741 109106838
Hip arthroplasty 25.41 11.17 951 1480769 54862 109052717
Haemophilus infection 25.40 11.17 89 1481631 2711 109104868
Therapy cessation 25.40 11.17 435 1481285 44422 109063157
Blood immunoglobulin A decreased 25.40 11.17 77 1481643 2171 109105408
Ecthyma 25.34 11.17 48 1481672 991 109106588
Application site pruritus 25.31 11.17 12 1481708 4148 109103431
Smoke sensitivity 25.25 11.17 39 1481681 678 109106901
Infection parasitic 25.23 11.17 44 1481676 850 109106729
Polydipsia 25.17 11.17 40 1481680 7648 109099931
Primary effusion lymphoma 25.16 11.17 14 1481706 54 109107525
Nasal disorder 25.15 11.17 118 1481602 4116 109103463
Tumour haemorrhage 25.14 11.17 20 1481700 5225 109102354
Mycoplasma test positive 25.03 11.17 24 1481696 246 109107333
Granulomatous dermatitis 24.99 11.17 33 1481687 493 109107086
Drug eruption 24.98 11.17 538 1481182 53121 109054458
Remission not achieved 24.95 11.17 33 1481687 494 109107085
Optic neuropathy 24.93 11.17 126 1481594 4532 109103047
Lung hyperinflation 24.85 11.17 76 1481644 2153 109105426
Localised infection 24.81 11.17 754 1480966 42294 109065285
Sinus disorder 24.80 11.17 594 1481126 32134 109075445
Eczema 24.78 11.17 758 1480962 71535 109036044
Haemolytic uraemic syndrome 24.72 11.17 132 1481588 4853 109102726
Sinus arrest 24.66 11.17 13 1481707 4229 109103350
Alcohol abuse 24.64 11.17 18 1481702 4911 109102668
Complications of transplanted heart 24.60 11.17 31 1481689 441 109107138
Disability 24.59 11.17 554 1481166 29669 109077910
Ageusia 24.58 11.17 158 1481562 19487 109088092
Myoglobin blood increased 24.56 11.17 13 1481707 4219 109103360
C-reactive protein increased 24.54 11.17 3306 1478414 214613 108892966
Rheumatoid factor negative 24.52 11.17 54 1481666 1246 109106333
Neoplasm progression 24.48 11.17 668 1481052 63927 109043652
Type 2 lepra reaction 24.46 11.17 29 1481691 386 109107193
HCoV-HKU1 infection 24.42 11.17 14 1481706 58 109107521
Propofol infusion syndrome 24.35 11.17 3 1481717 2586 109104993
Disinhibition 24.32 11.17 6 1481714 3128 109104451
Acquired apparent mineralocorticoid excess 24.31 11.17 16 1481704 89 109107490
Post transplant distal limb syndrome 24.29 11.17 43 1481677 841 109106738
Anion gap increased 24.26 11.17 14 1481706 4330 109103249
Blood immunoglobulin G decreased 24.11 11.17 139 1481581 5261 109102318
Cyst 24.11 11.17 332 1481388 16164 109091415
Herpes zoster meningoencephalitis 24.09 11.17 48 1481672 1030 109106549
Restrictive pulmonary disease 24.09 11.17 97 1481623 3162 109104417
Bartonellosis 24.00 11.17 12 1481708 35 109107544
Allergic fungal rhinosinusitis 23.99 11.17 13 1481707 47 109107532
Urinary tract candidiasis 23.98 11.17 51 1481669 1148 109106431
Cardioactive drug level increased 23.92 11.17 11 1481709 3871 109103708
Knee arthroplasty 23.92 11.17 1082 1480638 63866 109043713
Joint laxity 23.89 11.17 81 1481639 2426 109105153
Extrasystoles 23.87 11.17 47 1481673 8271 109099308
Renal vein thrombosis 23.84 11.17 49 1481671 1076 109106503
Drug-induced liver injury 23.83 11.17 1340 1480380 118727 108988852
Folliculitis 23.82 11.17 2581 1479139 165072 108942507
Brain natriuretic peptide increased 23.81 11.17 74 1481646 11135 109096444
Sneezing 23.78 11.17 579 1481141 31405 109076174
Neuralgia 23.76 11.17 482 1481238 47996 109059583
Encephalopathy 23.75 11.17 867 1480853 80188 109027391
Alveolar proteinosis 23.72 11.17 59 1481661 1477 109106102
Anger 23.71 11.17 153 1481567 18854 109088725
Neutrophilic dermatosis 23.69 11.17 40 1481680 752 109106827
Pasteurella infection 23.68 11.17 19 1481701 150 109107429
Peripheral arterial occlusive disease 23.67 11.17 56 1481664 9224 109098355
Multiple-drug resistance 23.67 11.17 94 1481626 13141 109094438
Tricuspid valve incompetence 23.67 11.17 205 1481515 23668 109083911
Paranasal sinus discomfort 23.65 11.17 157 1481563 6248 109101331
Virologic failure 23.59 11.17 19 1481701 4933 109102646
Injection site induration 23.58 11.17 76 1481644 11307 109096272
Blood cholesterol decreased 23.56 11.17 4 1481716 2712 109104867
Phaeohyphomycotic brain abscess 23.54 11.17 14 1481706 63 109107516
Epidural lipomatosis 23.54 11.17 71 1481649 1996 109105583
Oesophageal varices haemorrhage 23.52 11.17 19 1481701 4926 109102653
Prophylaxis against transplant rejection 23.50 11.17 16 1481704 95 109107484
Intestinal stenosis 23.48 11.17 125 1481595 4590 109102989
Acute myeloid leukaemia 23.46 11.17 673 1481047 37437 109070142
Hospitalisation 23.46 11.17 1618 1480102 140875 108966704
Hepatic cancer 23.45 11.17 74 1481646 11082 109096497
Hepatitis acute 23.44 11.17 151 1481569 18615 109088964
Erysipelothrix infection 23.42 11.17 8 1481712 4 109107575
Pleural thickening 23.42 11.17 99 1481621 3300 109104279
Capnocytophaga infection 23.41 11.17 20 1481700 174 109107405
Breast cancer 23.39 11.17 369 1481351 38173 109069406
Device deployment issue 23.33 11.17 14 1481706 4239 109103340
Hernia 23.26 11.17 379 1481341 19121 109088458
Episcleritis 23.22 11.17 52 1481668 1214 109106365
Cardiovascular disorder 23.21 11.17 194 1481526 22566 109085013
Segmental diverticular colitis 23.19 11.17 19 1481701 155 109107424
Antibody test positive 23.17 11.17 93 1481627 3027 109104552
Emotional distress 23.16 11.17 442 1481278 44405 109063174
Primary mediastinal large B-cell lymphoma recurrent 23.13 11.17 17 1481703 116 109107463
Fear of injection 23.09 11.17 201 1481519 8710 109098869
Myelodysplastic syndrome 23.09 11.17 662 1481058 36822 109070757
Herpes simplex encephalitis 23.08 11.17 41 1481679 804 109106775
Corynebacterium infection 23.06 11.17 69 1481651 1931 109105648
Acute hepatitis C 23.04 11.17 24 1481696 274 109107305
Diverticulum intestinal haemorrhagic 23.04 11.17 18 1481702 4745 109102834
International normalised ratio fluctuation 23 11.17 112 1481608 3968 109103611
Cutaneous calcification 22.94 11.17 21 1481699 202 109107377
Heavy menstrual bleeding 22.91 11.17 127 1481593 16238 109091341
Sudden cardiac death 22.89 11.17 25 1481695 5612 109101967
Hyperbilirubinaemia 22.76 11.17 282 1481438 30389 109077190
Symptom recurrence 22.74 11.17 125 1481595 4647 109102932
Multiple allergies 22.73 11.17 258 1481462 12005 109095574
Back pain 22.71 11.17 4504 1477216 366492 108741087
Bronchopleural fistula 22.71 11.17 42 1481678 851 109106728
Hypertrophic osteoarthropathy 22.68 11.17 17 1481703 120 109107459
Lung diffusion test decreased 22.67 11.17 61 1481659 1604 109105975
Meningitis pneumococcal 22.67 11.17 38 1481682 710 109106869
Thyroid neoplasm 22.63 11.17 96 1481624 3205 109104374
Traumatic lung injury 22.60 11.17 81 1481639 2496 109105083
Meningoencephalitis viral 22.59 11.17 32 1481688 513 109107066
Wheelchair user 22.51 11.17 181 1481539 7661 109099918
Graft complication 22.47 11.17 48 1481672 1084 109106495
Platelet count increased 22.46 11.17 486 1481234 25848 109081731
Tumour pain 22.41 11.17 6 1481714 2961 109104618
Morganella infection 22.39 11.17 54 1481666 1325 109106254
Retching 22.38 11.17 195 1481525 22487 109085092
Tracheal stenosis 22.35 11.17 35 1481685 616 109106963
Musculoskeletal pain 22.30 11.17 2790 1478930 180233 108927346
Emphysematous cystitis 22.27 11.17 35 1481685 618 109106961
Necrotising fasciitis fungal 22.26 11.17 11 1481709 31 109107548
Aplasia pure red cell 22.25 11.17 211 1481509 9367 109098212
BRASH syndrome 22.25 11.17 11 1481709 3712 109103867
Lactobacillus infection 22.24 11.17 31 1481689 489 109107090
Listeria encephalitis 22.24 11.17 25 1481695 313 109107266
Lacunar infarction 22.24 11.17 31 1481689 6255 109101324
Terminal ileitis 22.23 11.17 61 1481659 1623 109105956
Escherichia bacteraemia 22.19 11.17 221 1481499 9943 109097636
Nipple swelling 22.18 11.17 27 1481693 370 109107209
Skin toxicity 22.16 11.17 82 1481638 11701 109095878
Aspergilloma 22.13 11.17 39 1481681 760 109106819
Catheter site erythema 22.06 11.17 29 1481691 5999 109101580
Diverticulitis intestinal perforated 22.05 11.17 32 1481688 525 109107054
Hypoalbuminaemia 22.03 11.17 265 1481455 28709 109078870
Blood pressure inadequately controlled 22.02 11.17 43 1481677 7590 109099989
Urinary tract infection bacterial 21.98 11.17 184 1481536 7883 109099696
Laboratory test abnormal 21.98 11.17 437 1481283 43642 109063937
Laryngeal mass 21.97 11.17 14 1481706 73 109107506
Language disorder 21.96 11.17 12 1481708 3826 109103753
Vesicoureteric reflux 21.96 11.17 20 1481700 191 109107388
Small intestinal stenosis 21.95 11.17 52 1481668 1261 109106318
Extrapulmonary tuberculosis 21.87 11.17 32 1481688 529 109107050
Colon injury 21.86 11.17 27 1481693 376 109107203
Obstructive nephropathy 21.82 11.17 14 1481706 74 109107505
Device related infection 21.81 11.17 385 1481335 39134 109068445
Enuresis 21.76 11.17 14 1481706 4082 109103497
Pregnancy with implant contraceptive 21.70 11.17 3 1481717 2369 109105210
Genital herpes simplex 21.70 11.17 31 1481689 501 109107078
Urinoma 21.68 11.17 22 1481698 243 109107336
Ear congestion 21.67 11.17 102 1481618 3563 109104016
Decubitus ulcer 21.64 11.17 149 1481571 18087 109089492
Fulminant type 1 diabetes mellitus 21.59 11.17 3 1481717 2360 109105219
Pancreatitis 21.58 11.17 1028 1480692 92505 109015074
Atypical haemolytic uraemic syndrome 21.55 11.17 57 1481663 1483 109106096
Bronchial neoplasm 21.52 11.17 31 1481689 505 109107074
Panic attack 21.51 11.17 266 1481454 28674 109078905
Product complaint 21.49 11.17 105 1481615 13867 109093712
Colectomy total 21.49 11.17 30 1481690 474 109107105
Second primary malignancy 21.49 11.17 351 1481369 17717 109089862
Pemphigoid 21.47 11.17 165 1481555 19542 109088037
Cancer pain 21.46 11.17 36 1481684 6736 109100843
Complement factor C3 decreased 21.43 11.17 26 1481694 355 109107224
Osteomyelitis bacterial 21.36 11.17 32 1481688 541 109107038
Myringotomy 21.34 11.17 10 1481710 24 109107555
Combined immunodeficiency 21.31 11.17 19 1481701 176 109107403
CSF white blood cell count increased 21.31 11.17 17 1481703 133 109107446
Gastrosplenic fistula 21.31 11.17 17 1481703 133 109107446
Mycobacterium tuberculosis complex test positive 21.30 11.17 94 1481626 3194 109104385
Electrocardiogram ST segment elevation 21.26 11.17 58 1481662 9102 109098477
Tendon rupture 21.26 11.17 285 1481435 13793 109093786
Renal function test abnormal 21.25 11.17 56 1481664 8890 109098689
Bacterial pyelonephritis 21.23 11.17 39 1481681 786 109106793
Thrombosis in device 21.22 11.17 24 1481696 5303 109102276
Colon cancer 21.21 11.17 131 1481589 16312 109091267
Blood potassium decreased 21.19 11.17 557 1481163 53557 109054022
Anal abscess 21.19 11.17 244 1481476 11394 109096185
Type I hypersensitivity 21.18 11.17 33 1481687 6360 109101219
Folate deficiency 21.18 11.17 17 1481703 4421 109103158
Fungaemia 21.17 11.17 147 1481573 5939 109101640
Acute pulmonary oedema 21.11 11.17 137 1481583 16859 109090720
Joint destruction 21.09 11.17 232 1481488 10711 109096868
Initial insomnia 21.08 11.17 70 1481650 10319 109097260
Pulmonary tuberculosis 21.07 11.17 201 1481519 8938 109098641
Tendon disorder 21.06 11.17 187 1481533 8150 109099429
Product adhesion issue 21.03 11.17 7 1481713 2999 109104580
Immunoglobulin G4 related disease 20.97 11.17 27 1481693 393 109107186
Retroperitoneal lymphadenopathy 20.97 11.17 54 1481666 1382 109106197
Autonomic nervous system imbalance 20.96 11.17 28 1481692 5752 109101827
Blood chloride decreased 20.94 11.17 58 1481662 9057 109098522
Blood pH decreased 20.92 11.17 19 1481701 4650 109102929
International normalised ratio abnormal 20.88 11.17 33 1481687 6324 109101255
Epstein-Barr virus infection reactivation 20.84 11.17 109 1481611 3975 109103604
Abdominal wall infection 20.82 11.17 17 1481703 138 109107441
Eccrine carcinoma 20.80 11.17 10 1481710 26 109107553
Peripheral coldness 20.78 11.17 154 1481566 18386 109089193
International normalised ratio decreased 20.77 11.17 50 1481670 8186 109099393
Sebaceous carcinoma 20.77 11.17 18 1481702 160 109107419
Dyspepsia 20.75 11.17 2240 1479480 188725 108918854
Schizoaffective disorder 20.75 11.17 8 1481712 3128 109104451
Papilloedema 20.73 11.17 170 1481550 7239 109100340
Loss of libido 20.72 11.17 8 1481712 3125 109104454
Tongue necrosis 20.69 11.17 16 1481704 119 109107460
Apathy 20.63 11.17 130 1481590 16109 109091470
Cerebellar haemorrhage 20.58 11.17 9 1481711 3262 109104317
Infectious thyroiditis 20.57 11.17 19 1481701 185 109107394
Haemarthrosis 20.53 11.17 42 1481678 7287 109100292
Forced expiratory flow decreased 20.52 11.17 23 1481697 287 109107292
Bone density abnormal 20.49 11.17 105 1481615 3798 109103781
Hypofibrinogenaemia 20.47 11.17 77 1481643 2430 109105149
Crohn's disease 20.45 11.17 67 1481653 1971 109105608
Disseminated Bacillus Calmette-Guerin infection 20.44 11.17 24 1481696 316 109107263
Bursitis 20.44 11.17 1481 1480239 128437 108979142
Gastric haemorrhage 20.43 11.17 127 1481593 15788 109091791
Pleural mesothelioma malignant 20.42 11.17 18 1481702 164 109107415
Chronic myeloid leukaemia 20.41 11.17 112 1481608 4161 109103418
Faeces soft 20.40 11.17 235 1481485 10975 109096604
Endocarditis 20.32 11.17 271 1481449 13100 109094479
Gastrointestinal procedural complication 20.31 11.17 28 1481692 437 109107142
Cutaneous coccidioidomycosis 20.29 11.17 9 1481711 18 109107561
Diabetic cardiomyopathy 20.29 11.17 10 1481710 28 109107551
Asthmatic crisis 20.23 11.17 69 1481651 2073 109105506
Low density lipoprotein increased 20.21 11.17 74 1481646 10592 109096987
Anticipatory anxiety 20.20 11.17 49 1481671 1207 109106372
Dural arteriovenous fistula 20.19 11.17 14 1481706 86 109107493
Coronary arterial stent insertion 20.11 11.17 30 1481690 5885 109101694
Blood bicarbonate decreased 20.10 11.17 29 1481691 5768 109101811
Cytology abnormal 20.10 11.17 24 1481696 322 109107257
Coronavirus infection 20.10 11.17 206 1481514 9339 109098240
Antisynthetase syndrome 20.09 11.17 22 1481698 267 109107312
Lip oedema 20.08 11.17 45 1481675 7555 109100024
Large intestinal stenosis 20.06 11.17 102 1481618 3678 109103901
Product storage error 20.05 11.17 190 1481530 21538 109086041
Hepatitis C RNA increased 20.03 11.17 27 1481693 412 109107167
Factor V Leiden mutation 20.03 11.17 22 1481698 268 109107311
Immune reconstitution inflammatory syndrome 19.96 11.17 317 1481403 15909 109091670
Conjunctivitis allergic 19.91 11.17 160 1481560 6771 109100808
Bacillus infection 19.87 11.17 57 1481663 1557 109106022
Rhinitis 19.85 11.17 418 1481302 22127 109085452
Abdominal wall abscess 19.82 11.17 56 1481664 1516 109106063
Pleomorphic malignant fibrous histiocytoma 19.80 11.17 10 1481710 30 109107549
Diarrhoea haemorrhagic 19.80 11.17 307 1481413 15332 109092247
Disorder of orbit 19.78 11.17 16 1481704 128 109107451
Meningitis bacterial 19.77 11.17 89 1481631 3050 109104529
Perinephric collection 19.76 11.17 26 1481694 387 109107192
Glomerulonephritis rapidly progressive 19.75 11.17 70 1481650 2145 109105434
Proteinuria 19.72 11.17 688 1481032 39330 109068249
Cholecystitis acute 19.71 11.17 127 1481593 15655 109091924
Blood triglycerides increased 19.69 11.17 215 1481505 23711 109083868
Acute lymphocytic leukaemia recurrent 19.68 11.17 139 1481581 5648 109101931
Glomerulosclerosis 19.67 11.17 49 1481671 1228 109106351
Crepitations 19.65 11.17 227 1481493 10608 109096971
Superior sagittal sinus thrombosis 19.64 11.17 46 1481674 1107 109106472
Hypoaesthesia 19.60 11.17 3811 1477909 310412 108797167
Ophthalmic herpes simplex 19.59 11.17 40 1481680 874 109106705
Tetany 19.58 11.17 12 1481708 3592 109103987
Atrial flutter 19.58 11.17 219 1481501 24043 109083536
Acute myeloid leukaemia recurrent 19.56 11.17 24 1481696 5115 109102464
Blood iron decreased 19.52 11.17 364 1481356 18850 109088729
Skin fragility 19.51 11.17 46 1481674 1112 109106467
Soft tissue injury 19.50 11.17 71 1481649 2205 109105374
Poor quality product administered 19.50 11.17 20 1481700 4621 109102958
Throat irritation 19.47 11.17 891 1480829 52661 109054918
Intestinal resection 19.45 11.17 104 1481616 3825 109103754
Graft thrombosis 19.41 11.17 29 1481691 489 109107090
Pneumothorax spontaneous 19.38 11.17 61 1481659 1756 109105823
Demodicidosis 19.36 11.17 20 1481700 226 109107353
Spinal cord abscess 19.34 11.17 33 1481687 626 109106953
Myoclonic epilepsy 19.30 11.17 6 1481714 2685 109104894
Dysplastic naevus 19.24 11.17 38 1481682 810 109106769
Orbital apex syndrome 19.22 11.17 14 1481706 94 109107485
Pedal pulse abnormal 19.22 11.17 20 1481700 228 109107351
Nocardia sepsis 19.22 11.17 12 1481708 60 109107519
Pulmonary alveolar haemorrhage 19.20 11.17 378 1481342 19772 109087807
Peliosis hepatis 19.20 11.17 18 1481702 179 109107400
Gastritis erosive 19.15 11.17 89 1481631 11911 109095668
Incorrect dose administered by device 19.13 11.17 39 1481681 6775 109100804
Zoonotic bacterial infection 19.12 11.17 13 1481707 77 109107502
Cytomegalovirus mucocutaneous ulcer 19.11 11.17 16 1481704 135 109107444
Supraventricular tachycardia 19.10 11.17 222 1481498 24200 109083379
Hepatitis viral 19.05 11.17 53 1481667 1422 109106157
Mycetoma mycotic 19.04 11.17 26 1481694 402 109107177
Eyelid oedema 18.97 11.17 123 1481597 15139 109092440
Caesarean section 18.93 11.17 108 1481612 13709 109093870
Urate nephropathy 18.92 11.17 19 1481701 207 109107372
Disseminated intravascular coagulation 18.91 11.17 415 1481305 40871 109066708
Rectal tenesmus 18.91 11.17 70 1481650 2192 109105387
Psychiatric decompensation 18.87 11.17 30 1481690 5735 109101844
Unevaluable event 18.86 11.17 627 1481093 58600 109048979
Sleep apnoea syndrome 18.85 11.17 691 1481029 39756 109067823
Prostate cancer stage IV 18.85 11.17 5 1481715 2483 109105096
Cardiac failure acute 18.78 11.17 219 1481501 23859 109083720
Extradural abscess 18.75 11.17 65 1481655 1969 109105610
Rash papular 18.72 11.17 259 1481461 27380 109080199
BK polyomavirus test positive 18.72 11.17 22 1481698 290 109107289
Enterocolitis 18.66 11.17 163 1481557 18786 109088793
Chronic spontaneous urticaria 18.65 11.17 64 1481656 1929 109105650
Actinic keratosis 18.60 11.17 159 1481561 6854 109100725
Incoherent 18.60 11.17 54 1481666 8304 109099275
Paraesthesia oral 18.59 11.17 328 1481392 33343 109074236
Endometrial ablation 18.59 11.17 40 1481680 908 109106671
Gynaecomastia 18.54 11.17 65 1481655 9425 109098154
Clostridium difficile colitis 18.53 11.17 740 1480980 43038 109064541
Gastroenteritis listeria 18.52 11.17 7 1481713 7 109107572
Eye disorder 18.50 11.17 513 1481207 28393 109079186
Seasonal allergy 18.47 11.17 369 1481351 19353 109088226
Homicidal ideation 18.46 11.17 13 1481707 3614 109103965
Proteus infection 18.43 11.17 81 1481639 2747 109104832
Paradoxical drug reaction 18.40 11.17 207 1481513 9610 109097969
Fibromyalgia 18.40 11.17 2586 1479134 168323 108939256
Malignant melanoma in situ 18.39 11.17 95 1481625 3447 109104132
Pericardial effusion 18.39 11.17 605 1481115 56612 109050967
Freezing phenomenon 18.38 11.17 6 1481714 2603 109104976
Muscular weakness 18.36 11.17 2986 1478734 245482 108862097
Acute hepatic failure 18.35 11.17 361 1481359 36107 109071472
Hepatitis toxic 18.28 11.17 32 1481688 5889 109101690
Complications of transplanted liver 18.24 11.17 28 1481692 484 109107095
Psychotic symptom 18.22 11.17 15 1481705 3852 109103727
Lipase increased 18.22 11.17 161 1481559 18511 109089068
Angioimmunoblastic T-cell lymphoma 18.21 11.17 32 1481688 622 109106957
Pericardial haemorrhage 18.19 11.17 26 1481694 5191 109102388
Infusion site extravasation 18.18 11.17 237 1481483 11397 109096182
CNS ventriculitis 18.18 11.17 32 1481688 623 109106956
Cerebral venous sinus thrombosis 18.17 11.17 82 1481638 2813 109104766
Nasal turbinate hypertrophy 18.17 11.17 37 1481683 807 109106772
Lymphomatoid papulosis 18.14 11.17 25 1481695 390 109107189
Choriomeningitis lymphocytic 18.13 11.17 17 1481703 169 109107410
Infection in an immunocompromised host 18.13 11.17 62 1481658 1865 109105714
Haemorrhagic transformation stroke 18.11 11.17 9 1481711 3028 109104551
Diffuse mesangial sclerosis 18.06 11.17 12 1481708 68 109107511
Meningitis haemophilus 18.03 11.17 8 1481712 16 109107563
Chronic sinusitis 18.03 11.17 452 1481268 24632 109082947
Major depression 18.02 11.17 77 1481643 10544 109097035
Arteriospasm coronary 18.00 11.17 62 1481658 9038 109098541
Graft versus host disease 17.99 11.17 353 1481367 18453 109089126
Pyelonephritis fungal 17.94 11.17 22 1481698 304 109107275
Peripheral T-cell lymphoma unspecified 17.94 11.17 38 1481682 853 109106726
Tachyarrhythmia 17.93 11.17 54 1481666 8207 109099372
Aortic stenosis 17.93 11.17 102 1481618 12957 109094622
Segmented hyalinising vasculitis 17.88 11.17 13 1481707 87 109107492
Dysphoria 17.87 11.17 37 1481683 6391 109101188
Immune-mediated enterocolitis 17.80 11.17 73 1481647 10112 109097467
Prosthesis user 17.79 11.17 12 1481708 70 109107509
Nodal rhythm 17.77 11.17 12 1481708 3411 109104168
Escherichia urinary tract infection 17.77 11.17 310 1481410 15852 109091727
Herpes dermatitis 17.75 11.17 23 1481697 337 109107242
Adrenocortical insufficiency acute 17.73 11.17 111 1481609 4329 109103250
Biliary hamartoma 17.72 11.17 8 1481712 17 109107562
Meningoencephalitis amoebic 17.71 11.17 19 1481701 225 109107354
High density lipoprotein decreased 17.69 11.17 31 1481689 5702 109101877
Delayed recovery from anaesthesia 17.66 11.17 4 1481716 2211 109105368
Renal cyst 17.59 11.17 157 1481563 18015 109089564
Mantle cell lymphoma recurrent 17.55 11.17 41 1481679 985 109106594
Impaired gastric emptying 17.53 11.17 105 1481615 13170 109094409
Acute respiratory failure 17.52 11.17 1202 1480518 74058 109033521
Drug level fluctuating 17.50 11.17 40 1481680 947 109106632
Skin striae 17.47 11.17 67 1481653 2134 109105445
Urinary hesitation 17.47 11.17 22 1481698 4636 109102943
Leukopenia 17.46 11.17 2263 1479457 146528 108961051
Herpes zoster reactivation 17.45 11.17 25 1481695 405 109107174
Eosinophilic pneumonia chronic 17.44 11.17 29 1481691 538 109107041
Pain in jaw 17.44 11.17 537 1481183 50640 109056939
Blood thyroid stimulating hormone decreased 17.43 11.17 45 1481675 7194 109100385
Discoloured vomit 17.43 11.17 3 1481717 2014 109105565
Vascular stent thrombosis 17.40 11.17 18 1481702 4143 109103436
Parvovirus infection 17.37 11.17 39 1481681 912 109106667
Catatonia 17.33 11.17 85 1481635 11215 109096364
Vascular purpura 17.31 11.17 15 1481705 3756 109103823
Cytomegalovirus enteritis 17.28 11.17 42 1481678 1036 109106543
Oral pain 17.26 11.17 376 1481344 37068 109070511
Meningitis fungal 17.25 11.17 22 1481698 317 109107262
Substance use 17.24 11.17 6 1481714 2500 109105079
Escherichia sepsis 17.22 11.17 212 1481508 10060 109097519
Contusion 17.21 11.17 3460 1478260 229901 108877678
Tongue oedema 17.19 11.17 55 1481665 8201 109099378
Brain oedema 17.15 11.17 303 1481417 30795 109076784
Chronic obstructive pulmonary disease 17.14 11.17 1692 1480028 107466 109000113
Sinus arrhythmia 17.14 11.17 4 1481716 2166 109105413
Intestinal pseudo-obstruction 17.11 11.17 12 1481708 3344 109104235
Lymphadenopathy mediastinal 17.09 11.17 129 1481591 5355 109102224
Cardiomyopathy acute 17.06 11.17 24 1481696 382 109107197
Tonic convulsion 17.03 11.17 10 1481710 3064 109104515
Biphasic mesothelioma 17.02 11.17 11 1481709 59 109107520
Pyogenic granuloma 17.01 11.17 28 1481692 515 109107064
Injection site swelling 16.98 11.17 666 1481054 61124 109046455
Gastroenteritis sapovirus 16.98 11.17 18 1481702 210 109107369
Pre-eclampsia 16.95 11.17 184 1481536 8466 109099113
Acute polyneuropathy 16.93 11.17 34 1481686 734 109106845
Candida osteomyelitis 16.93 11.17 9 1481711 31 109107548
Food allergy 16.92 11.17 178 1481542 19770 109087809
Lupus vasculitis 16.90 11.17 30 1481690 588 109106991
Cardiac pseudoaneurysm 16.90 11.17 12 1481708 77 109107502
Renal cell carcinoma stage I 16.90 11.17 12 1481708 77 109107502
Cholestatic liver injury 16.90 11.17 47 1481673 7329 109100250
Laryngeal stenosis 16.85 11.17 49 1481671 1349 109106230
Diverticulitis 16.84 11.17 878 1480842 52644 109054935
Disseminated varicella 16.82 11.17 10 1481710 45 109107534
Orthostatic intolerance 16.81 11.17 4 1481716 2137 109105442
Systemic candida 16.79 11.17 206 1481514 9768 109097811
Haemodialysis 16.75 11.17 154 1481566 17565 109090014
Anticonvulsant drug level decreased 16.75 11.17 4 1481716 2132 109105447
Application site pain 16.72 11.17 30 1481690 5469 109102110
Slow speech 16.71 11.17 13 1481707 3435 109104144
Gastroenteritis viral 16.70 11.17 542 1481178 30684 109076895
Ileal ulcer 16.70 11.17 58 1481662 1759 109105820
Therapeutic product effect delayed 16.67 11.17 110 1481610 4369 109103210
Pseudomonal bacteraemia 16.66 11.17 108 1481612 4263 109103316
Acinetobacter infection 16.63 11.17 93 1481627 3480 109104099
Application site rash 16.63 11.17 6 1481714 2444 109105135
Fanconi syndrome acquired 16.63 11.17 10 1481710 3024 109104555
Drug withdrawal convulsions 16.62 11.17 6 1481714 2443 109105136
Posture abnormal 16.61 11.17 21 1481699 4417 109103162
Hidradenocarcinoma 16.59 11.17 8 1481712 21 109107558
Skin papilloma 16.56 11.17 153 1481567 6743 109100836
Bronchospasm 16.56 11.17 295 1481425 29944 109077635
Hypersensitivity myocarditis 16.55 11.17 22 1481698 331 109107248
Dizziness postural 16.54 11.17 121 1481599 14488 109093091
Enterocolonic fistula 16.54 11.17 16 1481704 166 109107413
Intestinal anastomosis 16.53 11.17 38 1481682 903 109106676
Tender joint count increased 16.53 11.17 24 1481696 394 109107185
Enterocolitis fungal 16.51 11.17 9 1481711 33 109107546
Blood iron abnormal 16.51 11.17 51 1481669 1453 109106126
Pleomorphism 16.45 11.17 7 1481713 12 109107567
Cardiac sarcoidosis 16.45 11.17 22 1481698 333 109107246
Abnormal loss of weight 16.41 11.17 76 1481644 10181 109097398
Peptostreptococcus infection 16.39 11.17 16 1481704 168 109107411
Prostate cancer metastatic 16.38 11.17 118 1481602 4825 109102754
Cutaneous T-cell lymphoma 16.37 11.17 89 1481631 3295 109104284
Liver transplant failure 16.33 11.17 15 1481705 145 109107434
Post procedural infection 16.32 11.17 268 1481452 13541 109094038
Splenic marginal zone lymphoma 16.31 11.17 12 1481708 82 109107497
Anticonvulsant drug level increased 16.26 11.17 9 1481711 2849 109104730
Joint warmth 16.22 11.17 63 1481657 2019 109105560
Enterobiasis 16.20 11.17 11 1481709 65 109107514
Germ cell cancer 16.19 11.17 17 1481703 196 109107383
Blood test abnormal 16.15 11.17 499 1481221 28055 109079524
Fanconi syndrome 16.15 11.17 14 1481706 3505 109104074
Prothrombin time shortened 16.14 11.17 15 1481705 3631 109103948
Follicular lymphoma 16.14 11.17 33 1481687 722 109106857
Acquired haemophilia 16.13 11.17 74 1481646 2557 109105022
Urticaria thermal 16.12 11.17 27 1481693 504 109107075
Acute promyelocytic leukaemia 16.12 11.17 59 1481661 1837 109105742
Jaundice cholestatic 16.06 11.17 122 1481598 14486 109093093
Diffuse alveolar damage 16.05 11.17 101 1481619 3946 109103633
Coagulation factor deficiency 16.04 11.17 21 1481699 311 109107268
Enzyme level abnormal 16.04 11.17 18 1481702 225 109107354
Refusal of treatment by patient 16.00 11.17 69 1481651 9425 109098154
Erythropoiesis abnormal 15.98 11.17 30 1481690 615 109106964
Alcohol use 15.96 11.17 19 1481701 4103 109103476
Electroencephalogram abnormal 15.95 11.17 37 1481683 6136 109101443
Suicidal behaviour 15.94 11.17 14 1481706 3483 109104096
Anaplastic large cell lymphoma T- and null-cell types 15.93 11.17 17 1481703 200 109107379
Meningitis candida 15.91 11.17 18 1481702 227 109107352
Bone loss 15.91 11.17 82 1481638 2973 109104606
Rhegmatogenous retinal detachment 15.91 11.17 19 1481701 255 109107324
Furuncle 15.90 11.17 182 1481538 8486 109099093
Depression suicidal 15.89 11.17 25 1481695 4799 109102780
Eosinophil count 15.89 11.17 16 1481704 175 109107404
Anovulatory cycle 15.85 11.17 14 1481706 128 109107451
Aortic dissection 15.84 11.17 26 1481694 4907 109102672
Pleocytosis 15.81 11.17 55 1481665 1669 109105910
Hypovolaemia 15.81 11.17 200 1481520 21474 109086105
Meningoencephalitis herpetic 15.81 11.17 69 1481651 2333 109105246
Prostatic abscess 15.80 11.17 29 1481691 584 109106995
Varices oesophageal 15.78 11.17 47 1481673 7168 109100411
Varicella virus test positive 15.77 11.17 23 1481697 379 109107200
Coeliac disease 15.75 11.17 449 1481271 42738 109064841
Nose deformity 15.74 11.17 19 1481701 258 109107321
Parathyroid gland enlargement 15.74 11.17 17 1481703 203 109107376
Borderline leprosy 15.71 11.17 10 1481710 52 109107527
Neoplasm recurrence 15.70 11.17 122 1481598 5110 109102469
Urine ketone body present 15.68 11.17 17 1481703 3829 109103750
Isosporiasis 15.68 11.17 16 1481704 178 109107401
Bronchial hyperreactivity 15.68 11.17 91 1481629 3453 109104126
Venoocclusive disease 15.66 11.17 39 1481681 6311 109101268
Unmasking of previously unidentified disease 15.65 11.17 78 1481642 2790 109104789
Hepatic artery aneurysm 15.65 11.17 12 1481708 88 109107491
Multiple fractures 15.64 11.17 186 1481534 8754 109098825
Compartment syndrome 15.61 11.17 35 1481685 5875 109101704
Cockroach allergy 15.59 11.17 13 1481707 109 109107470
Neovascularisation 15.58 11.17 55 1481665 1682 109105897
Respiratory tract infection fungal 15.57 11.17 46 1481674 1278 109106301
N-terminal prohormone brain natriuretic peptide increased 15.56 11.17 37 1481683 6084 109101495
Brain injury 15.56 11.17 111 1481609 13365 109094214
Pleural fibrosis 15.55 11.17 105 1481615 4203 109103376
Impulse-control disorder 15.54 11.17 5 1481715 2189 109105390
Urticaria 15.53 11.17 4641 1477079 314216 108793363
Gambling disorder 15.51 11.17 5 1481715 2186 109105393
Intervertebral disc degeneration 15.50 11.17 334 1481386 17751 109089828
Pseudopolyp 15.49 11.17 30 1481690 630 109106949
Genitourinary tract infection 15.49 11.17 20 1481700 292 109107287
Adrenal suppression 15.47 11.17 54 1481666 1642 109105937
Neck deformity 15.46 11.17 58 1481662 1828 109105751
Pneumopericardium 15.44 11.17 18 1481702 235 109107344
Mycobacterium kansasii infection 15.43 11.17 23 1481697 387 109107192
Osteomyelitis blastomyces 15.41 11.17 6 1481714 7 109107572
Polychondritis 15.39 11.17 37 1481683 906 109106673
Primary amyloidosis 15.39 11.17 20 1481700 294 109107285
Double stranded DNA antibody positive 15.36 11.17 27 1481693 525 109107054
Pathogen resistance 15.35 11.17 327 1481393 17345 109090234
Thrombosis 15.31 11.17 1250 1480470 107412 109000167
Cerebellar syndrome 15.31 11.17 39 1481681 6263 109101316
Bacterial sepsis 15.30 11.17 210 1481510 10216 109097363
Fungal abscess central nervous system 15.30 11.17 17 1481703 210 109107369
Prostate cancer stage I 15.29 11.17 8 1481712 2614 109104965
Systemic bacterial infection 15.28 11.17 10 1481710 55 109107524
Pancreatic carcinoma metastatic 15.27 11.17 20 1481700 4144 109103435
Autoinflammatory disease 15.24 11.17 22 1481698 359 109107220
Drug tolerance decreased 15.24 11.17 480 1481240 27060 109080519
Hypophysitis 15.19 11.17 31 1481689 5384 109102195
Pyoderma 15.18 11.17 27 1481693 530 109107049
Infective myositis 15.17 11.17 17 1481703 212 109107367
Brain stem haemorrhage 15.17 11.17 3 1481717 1823 109105756
Endocarditis staphylococcal 15.14 11.17 40 1481680 1040 109106539
Mouth haemorrhage 15.13 11.17 112 1481608 13376 109094203
Colitis microscopic 15.13 11.17 111 1481609 13283 109094296
Therapeutic response delayed 15.13 11.17 47 1481673 1343 109106236
Otorrhoea 15.12 11.17 65 1481655 2183 109105396
Haemolysis 15.11 11.17 294 1481426 15345 109092234
Nephrotic syndrome 15.10 11.17 265 1481455 13566 109094013
Salpingo-oophorectomy unilateral 15.09 11.17 34 1481686 797 109106782
Encephalitis brain stem 15.08 11.17 21 1481699 331 109107248
Splenic lesion 15.07 11.17 29 1481691 606 109106973
Meningitis coccidioides 15.05 11.17 9 1481711 41 109107538
Bacteroides bacteraemia 15.05 11.17 13 1481707 115 109107464
Inspiratory capacity decreased 15.02 11.17 8 1481712 2587 109104992
Device alarm issue 14.97 11.17 7 1481713 2439 109105140
Bundle branch block left 14.95 11.17 106 1481614 12782 109094797
Chronic hepatitis 14.95 11.17 55 1481665 1717 109105862
Pulmonary sarcoidosis 14.95 11.17 55 1481665 1717 109105862
Broncholithiasis 14.94 11.17 19 1481701 273 109107306
Haemorrhage 14.93 11.17 1228 1480492 105464 109002115
Osteomyelitis chronic 14.91 11.17 33 1481687 764 109106815
Kaposi sarcoma inflammatory cytokine syndrome 14.90 11.17 15 1481705 164 109107415
Kyphosis 14.87 11.17 83 1481637 3104 109104475
Chronic graft versus host disease in liver 14.86 11.17 36 1481684 886 109106693
Primary immunodeficiency syndrome 14.86 11.17 11 1481709 76 109107503
Pneumonia escherichia 14.85 11.17 43 1481677 1181 109106398
Pulseless electrical activity 14.84 11.17 148 1481572 16609 109090970
Differential white blood cell count abnormal 14.83 11.17 6 1481714 2278 109105301
Neck mass 14.79 11.17 113 1481607 4708 109102871
Leiomyosarcoma metastatic 14.75 11.17 8 1481712 29 109107550
Limb injury 14.74 11.17 631 1481089 37005 109070574
Hypochloraemia 14.74 11.17 16 1481704 3602 109103977
Forced expiratory volume 14.74 11.17 12 1481708 97 109107482
Cutaneous tuberculosis 14.68 11.17 19 1481701 278 109107301
Supraventricular extrasystoles 14.65 11.17 57 1481663 8016 109099563
Malacoplakia vesicae 14.63 11.17 11 1481709 78 109107501
Immune-mediated adrenal insuficiency 14.63 11.17 3 1481717 1777 109105802
Squamous cell carcinoma of the vagina 14.58 11.17 6 1481714 9 109107570
Bronchiolitis obliterans syndrome 14.56 11.17 30 1481690 660 109106919
Pseudomonas aeruginosa meningitis 14.54 11.17 12 1481708 99 109107480
Moraxella infection 14.54 11.17 32 1481688 738 109106841
Carbohydrate antigen 125 increased 14.52 11.17 8 1481712 2539 109105040
Atypical mycobacterial pneumonia 14.51 11.17 20 1481700 312 109107267
Peritoneal dialysis complication 14.51 11.17 8 1481712 2538 109105041
Enterococcal bacteraemia 14.50 11.17 106 1481614 4355 109103224
Urinary tract infection 14.50 11.17 4021 1477699 322261 108785318
Metabolic disorder 14.48 11.17 82 1481638 10428 109097151
Injection site necrosis 14.47 11.17 3 1481717 1763 109105816
Viral mutation identified 14.46 11.17 23 1481697 4396 109103183
Protein total decreased 14.45 11.17 86 1481634 10804 109096775
Injection site nodule 14.44 11.17 25 1481695 4621 109102958
Birdshot chorioretinopathy 14.42 11.17 11 1481709 80 109107499
Vitritis infective 14.41 11.17 9 1481711 45 109107534
Glomerulonephropathy 14.41 11.17 21 1481699 346 109107233
Platelet count abnormal 14.40 11.17 138 1481582 6144 109101435
Food intolerance 14.39 11.17 107 1481613 4420 109103159
Spinal disorder 14.38 11.17 229 1481491 11499 109096080
Vitamin D deficiency 14.37 11.17 169 1481551 18383 109089196
Euphoric mood 14.36 11.17 65 1481655 8762 109098817
Gastric ulcer haemorrhage, obstructive 14.35 11.17 7 1481713 19 109107560
Forced expiratory volume abnormal 14.34 11.17 14 1481706 147 109107432
Partial seizures 14.34 11.17 91 1481629 11258 109096321
Metabolic encephalopathy 14.33 11.17 88 1481632 10972 109096607
Skin bacterial infection 14.33 11.17 35 1481685 866 109106713
Nocardia test positive 14.32 11.17 5 1481715 3 109107576
Hilar lymphadenopathy 14.30 11.17 65 1481655 2237 109105342
Chemical peritonitis 14.29 11.17 19 1481701 286 109107293
Atlantoaxial instability 14.29 11.17 19 1481701 286 109107293
Hypervolaemia 14.28 11.17 530 1481190 48930 109058649
Acne 14.28 11.17 567 1481153 32953 109074626
Anosmia 14.27 11.17 103 1481617 12369 109095210
Myocardial oedema 14.24 11.17 28 1481692 595 109106984
Carotid arteriosclerosis 14.23 11.17 12 1481708 3045 109104534
Gastrointestinal mucormycosis 14.23 11.17 31 1481689 710 109106869
Septic vasculitis 14.21 11.17 6 1481714 10 109107569
Hepatocellular carcinoma 14.20 11.17 76 1481644 9804 109097775
Fluoride increased 14.20 11.17 11 1481709 82 109107497
Epstein Barr virus positive mucocutaneous ulcer 14.16 11.17 41 1481679 1126 109106453
Increased viscosity of bronchial secretion 14.14 11.17 28 1481692 598 109106981
Infusion site reaction 14.11 11.17 160 1481560 17522 109090057
Catheter site pain 14.09 11.17 42 1481678 6404 109101175
Ovarian cyst 14.09 11.17 119 1481601 13811 109093768
Bacterial pericarditis 14.08 11.17 12 1481708 104 109107475
Hepatitis G 14.08 11.17 12 1481708 104 109107475
Hangover 14.06 11.17 8 1481712 2494 109105085
Device use issue 14.06 11.17 18 1481702 3766 109103813
Hypersomnia 14.05 11.17 278 1481442 27783 109079796
Spinal instability 14 11.17 24 1481696 457 109107122
Coagulation factor V level abnormal 13.98 11.17 14 1481706 152 109107427
Vestibular disorder 13.97 11.17 9 1481711 2623 109104956
Abnormal faeces 13.96 11.17 187 1481533 9049 109098530
Molluscum contagiosum 13.95 11.17 28 1481692 604 109106975
Hepatitis fulminant 13.95 11.17 63 1481657 8497 109099082
Hepatosplenomegaly 13.94 11.17 148 1481572 6771 109100808
Cerebral venous thrombosis 13.94 11.17 83 1481637 3179 109104400
Photopsia 13.94 11.17 40 1481680 6174 109101405
Thymus hypoplasia 13.93 11.17 52 1481668 1635 109105944
Gastrointestinal scarring 13.93 11.17 24 1481696 459 109107120
Basal ganglia haemorrhage 13.92 11.17 4 1481716 1884 109105695
Central nervous system mass 13.91 11.17 33 1481687 801 109106778
Infected neoplasm 13.91 11.17 27 1481693 568 109107011
Polyarteritis nodosa 13.86 11.17 28 1481692 607 109106972
Epstein-Barr virus test negative 13.86 11.17 6 1481714 11 109107568
Parathyroid disorder 13.84 11.17 29 1481691 646 109106933
Acanthoma 13.82 11.17 9 1481711 49 109107530
Eczema herpeticum 13.82 11.17 24 1481696 462 109107117
Bacteroides test positive 13.80 11.17 8 1481712 34 109107545
Pneumomediastinum 13.79 11.17 115 1481605 4921 109102658
Underdose 13.79 11.17 703 1481017 62851 109044728
Acid fast bacilli infection 13.78 11.17 16 1481704 208 109107371
Meningoradiculitis 13.78 11.17 16 1481704 208 109107371
Alcohol poisoning 13.75 11.17 68 1481652 8952 109098627
Blood stem cell transplant failure 13.74 11.17 30 1481690 688 109106891
Nail bed inflammation 13.73 11.17 5 1481715 2025 109105554
Mixed liver injury 13.70 11.17 100 1481620 11979 109095600
Factor XIII deficiency 13.69 11.17 11 1481709 87 109107492
Joint ankylosis 13.69 11.17 68 1481652 2429 109105150
Herpes oesophagitis 13.66 11.17 22 1481698 397 109107182
Wound secretion 13.62 11.17 147 1481573 6754 109100825
Foetal exposure during pregnancy 13.61 11.17 53 1481667 7452 109100127
Blood urea decreased 13.60 11.17 16 1481704 3474 109104105
Muscle abscess 13.59 11.17 47 1481673 1422 109106157
Fracture delayed union 13.56 11.17 62 1481658 2139 109105440
Acute erythroid leukaemia 13.56 11.17 21 1481699 366 109107213
Blood sodium increased 13.56 11.17 34 1481686 5489 109102090
Pancreas transplant 13.54 11.17 9 1481711 51 109107528
Renal pseudoaneurysm 13.53 11.17 6 1481714 12 109107567
Endocarditis Q fever 13.53 11.17 6 1481714 12 109107567
Lung hernia 13.52 11.17 10 1481710 69 109107510
Apoptosis 13.52 11.17 30 1481690 696 109106883
Cardiac valve abscess 13.50 11.17 13 1481707 134 109107445
Premature labour 13.50 11.17 70 1481650 9102 109098477
Palatal ulcer 13.48 11.17 17 1481703 242 109107337
Atopy 13.48 11.17 40 1481680 1114 109106465
Lepromatous leprosy 13.47 11.17 12 1481708 111 109107468
Hirsutism 13.45 11.17 53 1481667 1710 109105869
Anal squamous cell carcinoma 13.45 11.17 33 1481687 819 109106760
Sputum abnormal 13.40 11.17 45 1481675 1341 109106238
Alcoholism 13.40 11.17 18 1481702 3689 109103890
Product residue present 13.39 11.17 20 1481700 3921 109103658
Chronic disease 13.38 11.17 16 1481704 215 109107364
Colonic abscess 13.38 11.17 55 1481665 1810 109105769
Porokeratosis 13.34 11.17 18 1481702 275 109107304
Genital lesion 13.33 11.17 25 1481695 512 109107067
Antithrombin III increased 13.30 11.17 4 1481716 0 109107579
Testicular embryonal carcinoma 13.30 11.17 4 1481716 0 109107579
Autoimmune thyroiditis 13.30 11.17 43 1481677 6391 109101188
Injury associated with device 13.30 11.17 24 1481696 4365 109103214
Solid organ transplant rejection 13.28 11.17 9 1481711 53 109107526
Diaphragm muscle weakness 13.27 11.17 15 1481705 189 109107390
Coronary artery occlusion 13.27 11.17 141 1481579 15631 109091948
Blood cholesterol 13.25 11.17 34 1481686 868 109106711
Breast pain 13.25 11.17 79 1481641 9921 109097658
Intestinal ulcer 13.24 11.17 66 1481654 2361 109105218
Membranous-like glomerulopathy with masked IgG-kappa deposits 13.23 11.17 5 1481715 5 109107574
Thyroid gland abscess 13.21 11.17 11 1481709 92 109107487
Coxsackie virus test positive 13.21 11.17 6 1481714 13 109107566
Hantaviral infection 13.21 11.17 6 1481714 13 109107566
Bone tuberculosis 13.18 11.17 30 1481690 708 109106871
Infective aneurysm 13.17 11.17 47 1481673 1445 109106134
Eye inflammation 13.17 11.17 184 1481536 8987 109098592
Complement factor C4 decreased 13.14 11.17 20 1481700 343 109107236
Tuberculosis liver 13.12 11.17 11 1481709 93 109107486
Prinzmetal angina 13.12 11.17 7 1481713 2262 109105317
Tongue biting 13.12 11.17 12 1481708 2927 109104652
Perirectal abscess 13.08 11.17 62 1481658 2172 109105407
Bladder pain 13.05 11.17 73 1481647 2732 109104847
Eosinophilic myocarditis 13.05 11.17 59 1481661 2026 109105553
Ureteritis 13.02 11.17 17 1481703 251 109107328
Cerebral atrophy 13.00 11.17 70 1481650 9015 109098564
Peripheral sensorimotor neuropathy 13.00 11.17 94 1481626 3849 109103730
Loss of employment 12.98 11.17 83 1481637 3261 109104318
Postoperative thoracic procedure complication 12.97 11.17 10 1481710 74 109107505
Sebaceous adenoma 12.97 11.17 8 1481712 39 109107540
Physical deconditioning 12.96 11.17 17 1481703 3520 109104059
Graft infection 12.95 11.17 31 1481689 757 109106822
Gastroenteritis Escherichia coli 12.95 11.17 43 1481677 1274 109106305
Oedematous kidney 12.92 11.17 17 1481703 253 109107326
Nephritis haemorrhagic 12.92 11.17 6 1481714 14 109107565
Bartonella test positive 12.92 11.17 6 1481714 14 109107565
Anogenital warts 12.92 11.17 39 1481681 1097 109106482
Soft tissue sarcoma 12.91 11.17 18 1481702 284 109107295
Renal aneurysm 12.91 11.17 18 1481702 284 109107295
Bone pain 12.91 11.17 727 1480993 64406 109043173
Quality of life decreased 12.90 11.17 264 1481456 13905 109093674
Hepatic fibrosis 12.89 11.17 165 1481555 7901 109099678
Rheumatoid factor increased 12.88 11.17 67 1481653 2438 109105141
Cytomegalovirus duodenitis 12.85 11.17 13 1481707 143 109107436
Arterial fibrosis 12.78 11.17 7 1481713 26 109107553
Infective uveitis 12.78 11.17 7 1481713 26 109107553
Pulmonary function test increased 12.77 11.17 5 1481715 6 109107573
Herpes zoster meningoradiculitis 12.77 11.17 5 1481715 6 109107573
Neuromyelitis optica spectrum disorder 12.76 11.17 47 1481673 1468 109106111
Premature ageing 12.76 11.17 11 1481709 97 109107482
Hypoxic-ischaemic encephalopathy 12.75 11.17 68 1481652 8779 109098800
Bone marrow oedema 12.75 11.17 60 1481660 2096 109105483
Immune-mediated lung disease 12.74 11.17 33 1481687 5270 109102309
Escherichia pyelonephritis 12.74 11.17 35 1481685 932 109106647
Libido decreased 12.74 11.17 39 1481681 5896 109101683
Enterocolitis viral 12.73 11.17 33 1481687 848 109106731
Craniocerebral injury 12.73 11.17 39 1481681 5895 109101684
Amenorrhoea 12.73 11.17 72 1481648 9159 109098420
Therapy change 12.71 11.17 80 1481640 9917 109097662
Cardiac infection 12.69 11.17 28 1481692 647 109106932
Nicotine dependence 12.68 11.17 43 1481677 1288 109106291
Epstein-Barr virus antigen positive 12.67 11.17 11 1481709 98 109107481
Psychogenic seizure 12.67 11.17 8 1481712 2356 109105223
Mycotic endophthalmitis 12.65 11.17 22 1481698 424 109107155
Tunnel vision 12.59 11.17 57 1481663 1958 109105621
Duodenal ulcer haemorrhage 12.59 11.17 60 1481660 7977 109099602
Implant site pain 12.57 11.17 7 1481713 2208 109105371
Growth retardation 12.55 11.17 68 1481652 2514 109105065
Pupil fixed 12.54 11.17 20 1481700 3818 109103761
Subacute endocarditis 12.53 11.17 14 1481706 174 109107405
Weight fluctuation 12.53 11.17 387 1481333 21758 109085821
Mastitis bacterial 12.52 11.17 9 1481711 59 109107520
Chills 12.52 11.17 2305 1479415 188275 108919304
Scrotal ulcer 12.51 11.17 22 1481698 428 109107151
Chylothorax 12.50 11.17 39 1481681 1117 109106462
Shoulder arthroplasty 12.48 11.17 87 1481633 3520 109104059
Orbital infection 12.47 11.17 14 1481706 175 109107404
Chronic papillomatous dermatitis 12.46 11.17 10 1481710 79 109107500
Osteonecrosis of jaw 12.46 11.17 521 1481199 47496 109060083
Orbital myositis 12.42 11.17 16 1481704 233 109107346
Oral lichenoid reaction 12.41 11.17 14 1481706 176 109107403
Hippocampal sclerosis 12.41 11.17 15 1481705 204 109107375
Anaplastic large cell lymphoma T- and null-cell types recurrent 12.41 11.17 9 1481711 60 109107519
Refractory cytopenia with unilineage dysplasia 12.40 11.17 33 1481687 862 109106717
Acidosis hyperchloraemic 12.38 11.17 3 1481717 1583 109105996
Arteriovenous fistula aneurysm 12.38 11.17 6 1481714 16 109107563
Skin infection 12.37 11.17 392 1481328 22117 109085462
Enthesophyte 12.37 11.17 13 1481707 150 109107429
Intestinal fistula 12.35 11.17 51 1481669 1682 109105897
Inspiratory capacity abnormal 12.33 11.17 11 1481709 102 109107477
Diffuse alopecia 12.32 11.17 43 1481677 1307 109106272
Airway remodelling 12.32 11.17 34 1481686 908 109106671
Skin reaction 12.31 11.17 204 1481516 20940 109086639
Troponin I increased 12.30 11.17 35 1481685 5417 109102162
Central obesity 12.28 11.17 57 1481663 1979 109105600
Incision site pain 12.28 11.17 78 1481642 3057 109104522
T-cell type acute leukaemia 12.27 11.17 19 1481701 331 109107248
Hepatic cyst 12.26 11.17 58 1481662 7725 109099854
Cervicitis 12.24 11.17 18 1481702 299 109107280
Pulmonary toxicity 12.23 11.17 318 1481402 17428 109090151
Cardiotoxicity 12.23 11.17 156 1481564 16725 109090854
Depersonalisation/derealisation disorder 12.22 11.17 7 1481713 2174 109105405
Anticoagulation drug level below therapeutic 12.20 11.17 4 1481716 1730 109105849
Pancreatitis chronic 12.16 11.17 26 1481694 4439 109103140
Bone infarction 12.15 11.17 26 1481694 588 109106991
Transverse sinus thrombosis 12.14 11.17 30 1481690 748 109106831
Thymoma 12.14 11.17 21 1481699 403 109107176
Oesophageal infection 12.14 11.17 30 1481690 748 109106831
Mediastinitis 12.13 11.17 44 1481676 1364 109106215
Intervertebral disc space narrowing 12.13 11.17 54 1481666 1842 109105737
Rectal prolapse 12.12 11.17 67 1481653 2496 109105083
Hepatic enzyme abnormal 12.11 11.17 191 1481529 9572 109098007
Acute lung injury 12.10 11.17 78 1481642 3073 109104506
Ear infection 12.09 11.17 987 1480733 61745 109045834
Hepatic angiosarcoma 12.08 11.17 11 1481709 105 109107474
Pericarditis infective 12.07 11.17 16 1481704 240 109107339
Acne fulminans 12.07 11.17 17 1481703 271 109107308
Oligoarthritis 12.06 11.17 30 1481690 751 109106828
Endotracheal intubation 12.06 11.17 42 1481678 6102 109101477
Foot fracture 12.05 11.17 437 1481283 25109 109082470
SJS-TEN overlap 12.04 11.17 5 1481715 1869 109105710
Derealisation 11.99 11.17 7 1481713 2151 109105428
Venoocclusive liver disease 11.98 11.17 138 1481582 15069 109092510
Glomerulonephritis minimal lesion 11.98 11.17 37 1481683 1054 109106525
Myocardiac abscess 11.98 11.17 10 1481710 84 109107495
Herpes zoster meningitis 11.97 11.17 16 1481704 242 109107337
T-cell prolymphocytic leukaemia 11.95 11.17 9 1481711 64 109107515
Electrocardiogram T wave abnormal 11.95 11.17 24 1481696 4193 109103386
Gait spastic 11.95 11.17 3 1481717 1546 109106033
Depressive symptom 11.94 11.17 65 1481655 8349 109099230
Neurogenic bladder 11.91 11.17 32 1481688 5047 109102532
Lung consolidation 11.90 11.17 202 1481518 10274 109097305
Orchitis 11.88 11.17 53 1481667 1809 109105770
Removal of internal fixation 11.88 11.17 6 1481714 18 109107561
Lymphoid tissue hypoplasia 11.87 11.17 49 1481671 1616 109105963
Ossicle disorder 11.86 11.17 7 1481713 31 109107548
Palatal oedema 11.82 11.17 4 1481716 1696 109105883
Feeling hot 11.80 11.17 1055 1480665 90051 109017528
Right ventricular hypertrophy 11.79 11.17 50 1481670 1669 109105910
Disturbance in social behaviour 11.76 11.17 32 1481688 5026 109102553
Post-acute COVID-19 syndrome 11.74 11.17 47 1481673 1528 109106051
Breast cancer stage II 11.74 11.17 278 1481442 27097 109080482
Transient acantholytic dermatosis 11.73 11.17 18 1481702 311 109107268
Wrong technique in device usage process 11.72 11.17 50 1481670 6851 109100728
Coordination abnormal 11.72 11.17 253 1481467 24975 109082604
Electrocardiogram PR prolongation 11.71 11.17 5 1481715 1838 109105741
Xanthogranuloma 11.71 11.17 10 1481710 87 109107492
Pulmonary vasculitis 11.70 11.17 137 1481583 6423 109101156
Adenomatous polyposis coli 11.69 11.17 18 1481702 312 109107267
Breast cancer recurrent 11.68 11.17 21 1481699 3825 109103754
Clostridial sepsis 11.67 11.17 36 1481684 1025 109106554
Pharyngeal paraesthesia 11.66 11.17 95 1481625 4037 109103542
Blood creatine phosphokinase MB increased 11.65 11.17 13 1481707 2890 109104689
Actinomycosis 11.65 11.17 42 1481678 1298 109106281
Multiple injuries 11.65 11.17 19 1481701 3595 109103984
Wall motion score index abnormal 11.64 11.17 31 1481689 810 109106769
Bacillus bacteraemia 11.64 11.17 16 1481704 249 109107330
Fluid intake reduced 11.63 11.17 51 1481669 6935 109100644
Sinus polyp degeneration 11.63 11.17 9 1481711 67 109107512
Ileectomy 11.62 11.17 17 1481703 281 109107298
Rhinitis perennial 11.62 11.17 15 1481705 219 109107360
Acute biphenotypic leukaemia 11.61 11.17 13 1481707 162 109107417
Actinomycotic skin infection 11.60 11.17 5 1481715 9 109107570
Sputum increased 11.58 11.17 123 1481597 5628 109101951
Nosocomial infection 11.56 11.17 78 1481642 3121 109104458
Plasmodium falciparum infection 11.55 11.17 13 1481707 163 109107416
Mediastinum neoplasm 11.53 11.17 11 1481709 112 109107467
Areflexia 11.53 11.17 49 1481671 6720 109100859
Pigment nephropathy 11.53 11.17 9 1481711 68 109107511
Hypertensive heart disease 11.51 11.17 28 1481692 4568 109103011
Device defective 11.49 11.17 21 1481699 3801 109103778
Acute myelomonocytic leukaemia 11.47 11.17 21 1481699 422 109107157
Nodular rash 11.45 11.17 18 1481702 318 109107261
Discouragement 11.45 11.17 59 1481661 2139 109105440
Blood 1,25-dihydroxycholecalciferol increased 11.44 11.17 10 1481710 90 109107489
Actinomycotic pulmonary infection 11.43 11.17 8 1481712 50 109107529
Disseminated large cell lymphoma 11.42 11.17 9 1481711 69 109107510
Procedural haemorrhage 11.41 11.17 36 1481684 5391 109102188
Dysaesthesia 11.39 11.17 50 1481670 6797 109100782
Injection site mass 11.39 11.17 247 1481473 24366 109083213
Acute lymphocytic leukaemia refractory 11.39 11.17 14 1481706 194 109107385
Vascular rupture 11.37 11.17 52 1481668 1794 109105785
Hepatitis C 11.36 11.17 234 1481486 12339 109095240
Paracoccidioides infection 11.35 11.17 10 1481710 91 109107488
Tooth abscess 11.34 11.17 331 1481389 18458 109089121
Hemianopia 11.34 11.17 13 1481707 2855 109104724
Transitional cell carcinoma metastatic 11.32 11.17 12 1481708 140 109107439
Prolonged expiration 11.32 11.17 46 1481674 1506 109106073
Self-medication 11.31 11.17 44 1481676 6188 109101391
Lip scab 11.31 11.17 11 1481709 115 109107464
Glomerulonephritis membranous 11.30 11.17 55 1481665 1948 109105631
Palindromic rheumatism 11.30 11.17 20 1481700 391 109107188
Lung infiltration 11.30 11.17 420 1481300 24208 109083371
Viral upper respiratory tract infection 11.29 11.17 196 1481524 10012 109097567
Infusion site erythema 11.28 11.17 104 1481616 11855 109095724
Transitional cell cancer of renal pelvis and ureter metastatic 11.27 11.17 5 1481715 10 109107569
Light chain analysis increased 11.26 11.17 9 1481711 2346 109105233
Cartilage injury 11.26 11.17 48 1481672 1606 109105973
SARS-CoV-2 viraemia 11.26 11.17 12 1481708 141 109107438
Intraventricular haemorrhage 11.25 11.17 37 1481683 5470 109102109
Dermatitis allergic 11.25 11.17 214 1481506 21510 109086069
Hypovolaemic shock 11.23 11.17 133 1481587 14450 109093129
Metastases to lymph nodes 11.23 11.17 138 1481582 14894 109092685
Skin atrophy 11.23 11.17 136 1481584 6428 109101151
Elbow operation 11.23 11.17 22 1481698 466 109107113
Allodynia 11.23 11.17 7 1481713 2076 109105503
Hyperferritinaemia 11.22 11.17 36 1481684 1047 109106532
Relapsing-remitting multiple sclerosis 11.22 11.17 7 1481713 2075 109105504
Bacterial test negative 11.21 11.17 6 1481714 21 109107558
Small cell lung cancer recurrent 11.21 11.17 7 1481713 35 109107544
Bedridden 11.21 11.17 247 1481473 13178 109094401
Intracranial pressure increased 11.20 11.17 201 1481519 10334 109097245
Burkholderia cepacia complex infection 11.20 11.17 22 1481698 467 109107112
Varicella zoster pneumonia 11.20 11.17 20 1481700 394 109107185
Blister 11.19 11.17 3311 1478409 224065 108883514
Vascular shunt 11.19 11.17 8 1481712 52 109107527
Antibody test negative 11.19 11.17 8 1481712 52 109107527
Gastrinoma 11.19 11.17 8 1481712 52 109107527
Inflammatory pseudotumour 11.19 11.17 10 1481710 93 109107486
Device failure 11.18 11.17 54 1481666 7153 109100426

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphopenia 28.93 26.46 9 252 51 113641

Pharmacologic Action:

SourceCodeDescription
ATC A07EA03 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC H02AB07 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018931 Antineoplastic Agents, Hormonal
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35472 anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37962 adrenergic agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76595 nephroprotective agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

A07EA Corticosteroids acting locally 6 drugs
beclometasone dipropionatebetamethasonebudesonidehydrocortisoneprednisolonetixocortol
H02AB Glucocorticoids 15 drugs
betamethasonecloprednolcortivazoldeflazacortdexamethasonefluocortolonehydrocortisonemeprednisonemethylprednisoloneparamethasone acetateprednisoloneprednylidene show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Acute lymphoid leukemia indication 91857003 DOID:9952
Chronic lymphoid leukemia, disease indication 92814006
Disorder of skin indication 95320005 DOID:37
Diffuse non-Hodgkin's lymphoma, large cell indication 109969005
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Asthma indication 195967001 DOID:2841
Transplanted organ rejection indication 213148006
Adrenogenital disorder indication 267395000 DOID:0050811
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Prevention of Transplant Rejection indication
Erythroblastic Anemia indication
Systemic Dermatomyositis indication
Diffuse Proliferative Lupus Nephritis indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Pemphigoid off-label use 86142006
Myasthenia gravis off-label use 91637004 DOID:437
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Bell's palsy off-label use 193093009 DOID:12506
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Pure Red Cell Aplasia associated with Chronic Lymphocytic Leukemia off-label use
Metastatic Prostate Carcinoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Cluster Headache Prevention off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation Indication
Dogs Inflammation Indication
Horses Inflammation Indication

🐶 Veterinary products

ProductApplicantIngredients
Meticorten Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.33 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
1MG RAYOS HORIZON N202020 July 26, 2012 DISCN TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
2MG RAYOS HORIZON N202020 July 26, 2012 DISCN TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 DISCN TABLET, DELAYED RELEASE ORAL 9504699 Aug. 3, 2027 TREATMENT OF DISEASES OR CONDITIONS BY THE USE OF A DELAYED-RELEASE 1,2, OR 5MG PREDNISONE TABLET
5MG RAYOS HORIZON N202020 July 26, 2012 DISCN TABLET, DELAYED RELEASE ORAL 8168218 Jan. 7, 2028 TREATMENT OF RHEUMATOLOGIC, ALLERGIC, PULMONARY, GASTROINTESTINAL, DERMATOLOGIC DISEASES OR CONDITIONS BY THE USE OF A DELAYED RELEASE 5MG PREDNISONE TABLET

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8 WOMBAT-PK CHEMBL
Sodium/nucleoside cotransporter 1 Transporter Ki 5.77 DRUG MATRIX
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4017876 VUID
N0000146229 NUI
D00473 KEGG_DRUG
4017876 VANDF
C0032952 UMLSCUI
CHEBI:8382 CHEBI
PDN PDB_CHEM_ID
CHEMBL635 ChEMBL_ID
DB00635 DRUGBANK_ID
D011241 MESH_DESCRIPTOR_UI
5865 PUBCHEM_CID
7096 IUPHAR_LIGAND_ID
536 INN_ID
VB0R961HZT UNII
8640 RXNORM
287 MMSL
5351 MMSL
72025 MMSL
d00350 MMSL
002164 NDDF
10312003 SNOMEDCT_US
116602009 SNOMEDCT_US
VB0R961HZT INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0017 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0018 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-0019 TABLET 50 mg ORAL ANDA 10 sections
PredniSONE Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3721 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-3722 SOLUTION 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4728 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4741 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-4742 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8724 TABLET 5 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8739 TABLET 1 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-8740 TABLET 2.50 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9817 TABLET 10 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9818 TABLET 20 mg ORAL ANDA 10 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0054-9828 TABLET 5 mg ORAL ANDA 10 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0640 TABLET 5 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0641 TABLET 10 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0378-0642 TABLET 20 mg ORAL ANDA 21 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0440-8165 TABLET 5 mg ORAL ANDA 14 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0440-8167 TABLET 20 mg ORAL ANDA 14 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0463-6141 TABLET 20 mg ORAL ANDA 20 sections
PredniSONE HUMAN PRESCRIPTION DRUG LABEL 1 0463-6155 TABLET 5 mg ORAL ANDA 20 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0591-5052 TABLET 5 mg ORAL ANDA 20 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0591-5442 TABLET 10 mg ORAL ANDA 20 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0591-5443 TABLET 20 mg ORAL ANDA 20 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0603-5335 TABLET 1 mg ORAL ANDA 23 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0603-5336 TABLET 2.50 mg ORAL ANDA 23 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0603-5337 TABLET 5 mg ORAL ANDA 23 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0603-5338 TABLET 10 mg ORAL ANDA 23 sections
Prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0603-5339 TABLET 20 mg ORAL ANDA 23 sections
prednisone HUMAN PRESCRIPTION DRUG LABEL 1 0615-8438 TABLET 1 mg ORAL ANDA 11 sections