Stem definition | Drug id | CAS RN |
---|---|---|
heparin derivatives including low molecular mass heparins | 4840 | 9041-08-1 |
Molecule | Description |
---|---|
Synonyms:
|
A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)
|
Dose | Unit | Route |
---|---|---|
3.50 | TU | P |
2.50 | TU | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 22, 1994 | FDA | PFIZER INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary embolism | 211.00 | 12.80 | 246 | 22911 | 101458 | 50480509 |
Hepatocellular injury | 144.74 | 12.80 | 109 | 23048 | 25838 | 50556129 |
Drug ineffective | 136.60 | 12.80 | 106 | 23051 | 819227 | 49762740 |
Toxic epidermal necrolysis | 123.36 | 12.80 | 91 | 23066 | 20901 | 50561066 |
Acute kidney injury | 120.91 | 12.80 | 299 | 22858 | 227759 | 50354208 |
Thrombocytopenia | 106.22 | 12.80 | 201 | 22956 | 127472 | 50454495 |
Heparin-induced thrombocytopenia | 94.97 | 12.80 | 43 | 23114 | 3922 | 50578045 |
General physical health deterioration | 83.14 | 12.80 | 194 | 22963 | 142240 | 50439727 |
Cholestasis | 78.42 | 12.80 | 76 | 23081 | 25325 | 50556642 |
Deep vein thrombosis | 73.16 | 12.80 | 125 | 23032 | 73179 | 50508788 |
Needle issue | 70.38 | 12.80 | 43 | 23114 | 7232 | 50574735 |
Anaemia | 70.19 | 12.80 | 264 | 22893 | 252192 | 50329775 |
Drug intolerance | 65.13 | 12.80 | 11 | 23146 | 219093 | 50362874 |
Arthralgia | 62.85 | 12.80 | 65 | 23092 | 438637 | 50143330 |
Rheumatoid arthritis | 58.39 | 12.80 | 11 | 23146 | 202539 | 50379428 |
Product dose omission issue | 57.43 | 12.80 | 8 | 23149 | 183830 | 50398137 |
Neutropenic sepsis | 54.68 | 12.80 | 48 | 23109 | 14099 | 50567868 |
Arthropathy | 54.00 | 12.80 | 5 | 23152 | 157901 | 50424066 |
Drug reaction with eosinophilia and systemic symptoms | 52.64 | 12.80 | 65 | 23092 | 28359 | 50553608 |
Biliary sepsis | 51.42 | 12.80 | 18 | 23139 | 832 | 50581135 |
Rash maculo-papular | 51.08 | 12.80 | 62 | 23095 | 26579 | 50555388 |
Blue toe syndrome | 51.06 | 12.80 | 15 | 23142 | 391 | 50581576 |
Blood creatine increased | 50.14 | 12.80 | 30 | 23127 | 4857 | 50577110 |
Arteriovenous fistula occlusion | 47.65 | 12.80 | 14 | 23143 | 365 | 50581602 |
Therapeutic product effect decreased | 47.35 | 12.80 | 4 | 23153 | 136046 | 50445921 |
Jaundice | 46.65 | 12.80 | 59 | 23098 | 26370 | 50555597 |
Venous pressure jugular decreased | 45.95 | 12.80 | 9 | 23148 | 35 | 50581932 |
Neutropenia | 45.49 | 12.80 | 160 | 22997 | 147805 | 50434162 |
Abdominal discomfort | 45.03 | 12.80 | 25 | 23132 | 231616 | 50350351 |
Hyperthyroidism | 44.45 | 12.80 | 40 | 23117 | 12135 | 50569832 |
Melaena | 44.32 | 12.80 | 58 | 23099 | 26806 | 50555161 |
Vessel puncture site bruise | 43.92 | 12.80 | 13 | 23144 | 348 | 50581619 |
Dermatitis exfoliative | 43.71 | 12.80 | 28 | 23129 | 5114 | 50576853 |
Sinusitis | 43.67 | 12.80 | 12 | 23145 | 170546 | 50411421 |
Febrile neutropenia | 43.34 | 12.80 | 120 | 23037 | 97547 | 50484420 |
Agranulocytosis | 42.95 | 12.80 | 51 | 23106 | 21370 | 50560597 |
Gamma-glutamyltransferase increased | 41.37 | 12.80 | 59 | 23098 | 29564 | 50552403 |
Glossodynia | 41.33 | 12.80 | 3 | 23154 | 115566 | 50466401 |
Pituitary tumour | 39.92 | 12.80 | 15 | 23142 | 850 | 50581117 |
Adrenal suppression | 39.81 | 12.80 | 15 | 23142 | 857 | 50581110 |
Headache | 39.38 | 12.80 | 111 | 23046 | 506424 | 50075543 |
Ovarian hyperstimulation syndrome | 38.81 | 12.80 | 22 | 23135 | 3222 | 50578745 |
Thrombosis | 38.08 | 12.80 | 81 | 23076 | 55752 | 50526215 |
Joint swelling | 37.77 | 12.80 | 34 | 23123 | 245252 | 50336715 |
Systemic lupus erythematosus | 37.71 | 12.80 | 9 | 23148 | 140613 | 50441354 |
Haematoma | 37.19 | 12.80 | 57 | 23100 | 30453 | 50551514 |
Haemoglobin decreased | 36.90 | 12.80 | 135 | 23022 | 127081 | 50454886 |
Alopecia | 36.51 | 12.80 | 35 | 23122 | 245012 | 50336955 |
Blood loss anaemia | 36.33 | 12.80 | 30 | 23127 | 8109 | 50573858 |
Drug hypersensitivity | 36.08 | 12.80 | 37 | 23120 | 250973 | 50330994 |
Hypothalamo-pituitary disorder | 35.71 | 12.80 | 13 | 23144 | 674 | 50581293 |
Body dysmorphic disorder | 34.25 | 12.80 | 10 | 23147 | 255 | 50581712 |
Ascites | 34.24 | 12.80 | 60 | 23097 | 35801 | 50546166 |
Activated partial thromboplastin time prolonged | 33.71 | 12.80 | 26 | 23131 | 6376 | 50575591 |
Sepsis | 33.57 | 12.80 | 135 | 23022 | 132790 | 50449177 |
Malignant neoplasm progression | 33.53 | 12.80 | 87 | 23070 | 68037 | 50513930 |
Discomfort | 33.17 | 12.80 | 5 | 23152 | 108375 | 50473592 |
Blood creatinine increased | 32.23 | 12.80 | 92 | 23065 | 76068 | 50505899 |
Pancytopenia | 32.21 | 12.80 | 98 | 23059 | 83932 | 50498035 |
Pyrexia | 31.93 | 12.80 | 289 | 22868 | 379914 | 50202053 |
Perforation | 31.43 | 12.80 | 13 | 23144 | 951 | 50581016 |
Abdominal wall haematoma | 31.41 | 12.80 | 18 | 23139 | 2690 | 50579277 |
Treatment failure | 31.14 | 12.80 | 12 | 23145 | 137625 | 50444342 |
Cytokine release syndrome | 30.79 | 12.80 | 28 | 23129 | 8606 | 50573361 |
Depression | 30.50 | 12.80 | 19 | 23138 | 165404 | 50416563 |
Abdominal wall haemorrhage | 30.41 | 12.80 | 8 | 23149 | 137 | 50581830 |
Cardiac failure | 30.39 | 12.80 | 90 | 23067 | 75950 | 50506017 |
Pneumothorax traumatic | 29.48 | 12.80 | 8 | 23149 | 155 | 50581812 |
Pain | 29.31 | 12.80 | 151 | 23006 | 578752 | 50003215 |
Fatigue | 29.26 | 12.80 | 197 | 22960 | 707404 | 49874563 |
Epistaxis | 28.77 | 12.80 | 79 | 23078 | 63875 | 50518092 |
Hyperkalaemia | 28.54 | 12.80 | 66 | 23091 | 48023 | 50533944 |
Drug interaction | 28.34 | 12.80 | 172 | 22985 | 199449 | 50382518 |
Wound | 27.91 | 12.80 | 7 | 23150 | 105787 | 50476180 |
Cardiomyopathy acute | 27.82 | 12.80 | 8 | 23149 | 193 | 50581774 |
Haematoma muscle | 27.80 | 12.80 | 11 | 23146 | 717 | 50581250 |
Joint ankylosis | 27.29 | 12.80 | 11 | 23146 | 753 | 50581214 |
Gastric antral vascular ectasia | 27.18 | 12.80 | 10 | 23147 | 534 | 50581433 |
Gastrointestinal haemorrhage | 26.70 | 12.80 | 84 | 23073 | 73237 | 50508730 |
Electrolyte imbalance | 26.67 | 12.80 | 36 | 23121 | 17133 | 50564834 |
Intra-abdominal haemorrhage | 26.41 | 12.80 | 15 | 23142 | 2205 | 50579762 |
Premature baby | 26.31 | 12.80 | 37 | 23120 | 18300 | 50563667 |
Exposure during pregnancy | 25.98 | 12.80 | 117 | 23040 | 120898 | 50461069 |
Pericarditis | 25.58 | 12.80 | 3 | 23154 | 78686 | 50503281 |
Catheter site thrombosis | 25.49 | 12.80 | 7 | 23150 | 142 | 50581825 |
Cerebral haemorrhage | 25.48 | 12.80 | 45 | 23112 | 27007 | 50554960 |
Haemorrhagic erosive gastritis | 25.15 | 12.80 | 8 | 23149 | 274 | 50581693 |
Bronchopulmonary dysplasia | 25.15 | 12.80 | 8 | 23149 | 274 | 50581693 |
Bone marrow eosinophilic leukocyte count increased | 25.03 | 12.80 | 5 | 23152 | 22 | 50581945 |
Psychiatric decompensation | 25.02 | 12.80 | 12 | 23145 | 1246 | 50580721 |
Muscle haemorrhage | 24.88 | 12.80 | 16 | 23141 | 2942 | 50579025 |
Musculoskeletal stiffness | 24.75 | 12.80 | 14 | 23143 | 128467 | 50453500 |
Disease progression | 24.70 | 12.80 | 98 | 23059 | 95768 | 50486199 |
Cholecystitis | 24.53 | 12.80 | 31 | 23126 | 13840 | 50568127 |
Neoplasm progression | 24.30 | 12.80 | 46 | 23111 | 29111 | 50552856 |
Fracture blisters | 24.20 | 12.80 | 6 | 23151 | 80 | 50581887 |
Allergic hepatitis | 24.03 | 12.80 | 5 | 23152 | 28 | 50581939 |
Feeling abnormal | 23.71 | 12.80 | 14 | 23143 | 125478 | 50456489 |
Constipation | 23.24 | 12.80 | 155 | 23002 | 185553 | 50396414 |
Renal tubular acidosis | 22.77 | 12.80 | 12 | 23145 | 1522 | 50580445 |
Contraindicated product administered | 22.49 | 12.80 | 21 | 23136 | 148937 | 50433030 |
Multiple organ dysfunction syndrome | 22.46 | 12.80 | 62 | 23095 | 50275 | 50531692 |
Pleural effusion | 22.39 | 12.80 | 85 | 23072 | 81369 | 50500598 |
Femoral neck fracture | 22.34 | 12.80 | 22 | 23135 | 7468 | 50574499 |
Hepatitis cholestatic | 22.13 | 12.80 | 20 | 23137 | 6097 | 50575870 |
Haemoptysis | 22.13 | 12.80 | 41 | 23116 | 25532 | 50556435 |
Pneumobilia | 22.07 | 12.80 | 6 | 23151 | 117 | 50581850 |
Retroperitoneal haemorrhage | 21.93 | 12.80 | 14 | 23143 | 2542 | 50579425 |
Embolism | 21.78 | 12.80 | 21 | 23136 | 6947 | 50575020 |
Erythema | 21.29 | 12.80 | 127 | 23030 | 146287 | 50435680 |
International normalised ratio increased | 21.11 | 12.80 | 55 | 23102 | 43097 | 50538870 |
Respiratory disorder | 20.97 | 12.80 | 45 | 23112 | 31142 | 50550825 |
Granulomatous liver disease | 20.83 | 12.80 | 9 | 23148 | 734 | 50581233 |
Foetal growth restriction | 20.77 | 12.80 | 20 | 23137 | 6607 | 50575360 |
Therapeutic product effect incomplete | 20.66 | 12.80 | 8 | 23149 | 91507 | 50490460 |
Thrombophlebitis | 20.55 | 12.80 | 16 | 23141 | 3977 | 50577990 |
Hyperlipasaemia | 20.33 | 12.80 | 8 | 23149 | 514 | 50581453 |
Eosinophilia | 20.17 | 12.80 | 33 | 23124 | 18619 | 50563348 |
Caesarean section | 20.16 | 12.80 | 30 | 23127 | 15609 | 50566358 |
Diarrhoea haemorrhagic | 20.07 | 12.80 | 21 | 23136 | 7654 | 50574313 |
Leukopenia | 19.84 | 12.80 | 72 | 23085 | 67456 | 50514511 |
Limbal swelling | 19.77 | 12.80 | 4 | 23153 | 19 | 50581948 |
Cholestatic liver injury | 19.68 | 12.80 | 12 | 23145 | 2009 | 50579958 |
Cardiac failure congestive | 19.68 | 12.80 | 7 | 23150 | 84375 | 50497592 |
Impaired healing | 19.64 | 12.80 | 4 | 23153 | 69782 | 50512185 |
Anaemia folate deficiency | 19.52 | 12.80 | 6 | 23151 | 183 | 50581784 |
Diarrhoea | 19.39 | 12.80 | 377 | 22780 | 588099 | 49993868 |
Phlebitis | 19.33 | 12.80 | 18 | 23139 | 5702 | 50576265 |
Cerebral infarction | 19.15 | 12.80 | 35 | 23122 | 21569 | 50560398 |
Hypersensitivity | 19.08 | 12.80 | 44 | 23113 | 215117 | 50366850 |
Gastric ulcer | 18.23 | 12.80 | 34 | 23123 | 21271 | 50560696 |
Haemangioma congenital | 18.06 | 12.80 | 7 | 23150 | 432 | 50581535 |
Protein S decreased | 17.99 | 12.80 | 4 | 23153 | 32 | 50581935 |
Alanine aminotransferase increased | 17.89 | 12.80 | 84 | 23073 | 88275 | 50493692 |
Faecaloma | 17.79 | 12.80 | 19 | 23138 | 7089 | 50574878 |
Protein C decreased | 17.67 | 12.80 | 4 | 23153 | 35 | 50581932 |
Blood alkaline phosphatase increased | 17.51 | 12.80 | 47 | 23110 | 37479 | 50544488 |
Acute generalised exanthematous pustulosis | 17.45 | 12.80 | 21 | 23136 | 8917 | 50573050 |
Subcutaneous haematoma | 17.38 | 12.80 | 10 | 23147 | 1505 | 50580462 |
Lordosis | 17.27 | 12.80 | 6 | 23151 | 271 | 50581696 |
Maternal drugs affecting foetus | 17.20 | 12.80 | 16 | 23141 | 5061 | 50576906 |
Intra-abdominal haematoma | 17.13 | 12.80 | 10 | 23147 | 1547 | 50580420 |
Premature delivery | 16.90 | 12.80 | 35 | 23122 | 23628 | 50558339 |
Chemotherapeutic drug level increased | 16.82 | 12.80 | 5 | 23152 | 136 | 50581831 |
Cerebral haematoma | 16.81 | 12.80 | 13 | 23144 | 3198 | 50578769 |
Haemolysis | 16.71 | 12.80 | 17 | 23140 | 5999 | 50575968 |
Chest X-ray abnormal | 16.67 | 12.80 | 14 | 23143 | 3871 | 50578096 |
Hypokalaemia | 16.62 | 12.80 | 82 | 23075 | 87910 | 50494057 |
Haemorrhage | 16.57 | 12.80 | 58 | 23099 | 53383 | 50528584 |
Visual acuity reduced transiently | 16.54 | 12.80 | 5 | 23152 | 144 | 50581823 |
Gastrointestinal tract adenoma | 16.32 | 12.80 | 6 | 23151 | 320 | 50581647 |
Skin warm | 16.19 | 12.80 | 15 | 23142 | 4720 | 50577247 |
Varices oesophageal | 16.17 | 12.80 | 12 | 23145 | 2777 | 50579190 |
Toxicity to various agents | 16.12 | 12.80 | 47 | 23110 | 212452 | 50369515 |
Abdominal pain | 16.07 | 12.80 | 172 | 22985 | 236056 | 50345911 |
Magnetic resonance imaging head abnormal | 15.91 | 12.80 | 10 | 23147 | 1767 | 50580200 |
Blood cholesterol increased | 15.89 | 12.80 | 3 | 23154 | 55212 | 50526755 |
Interstitial lung disease | 15.88 | 12.80 | 57 | 23100 | 53119 | 50528848 |
Infantile haemangioma | 15.82 | 12.80 | 4 | 23153 | 58 | 50581909 |
Ill-defined disorder | 15.66 | 12.80 | 3 | 23154 | 54651 | 50527316 |
Infusion related reaction | 15.58 | 12.80 | 34 | 23123 | 169523 | 50412444 |
Intracranial pressure increased | 15.58 | 12.80 | 14 | 23143 | 4238 | 50577729 |
Persecutory delusion | 15.50 | 12.80 | 11 | 23146 | 2376 | 50579591 |
Cardiac hypertrophy | 15.43 | 12.80 | 8 | 23149 | 981 | 50580986 |
Acidosis | 15.21 | 12.80 | 21 | 23136 | 10206 | 50571761 |
Normal newborn | 15.21 | 12.80 | 17 | 23140 | 6674 | 50575293 |
Gastrointestinal disorder | 14.62 | 12.80 | 13 | 23144 | 94443 | 50487524 |
Upper gastrointestinal haemorrhage | 14.24 | 12.80 | 26 | 23131 | 16009 | 50565958 |
Stevens-Johnson syndrome | 14.18 | 12.80 | 31 | 23126 | 21721 | 50560246 |
Renal pain | 14.03 | 12.80 | 15 | 23142 | 5604 | 50576363 |
Vascular occlusion | 13.92 | 12.80 | 7 | 23150 | 806 | 50581161 |
Bone marrow oedema | 13.91 | 12.80 | 7 | 23150 | 807 | 50581160 |
Hypoaesthesia | 13.89 | 12.80 | 23 | 23134 | 127234 | 50454733 |
Reticulocyte count increased | 13.88 | 12.80 | 7 | 23150 | 811 | 50581156 |
Post procedural haematoma | 13.86 | 12.80 | 8 | 23149 | 1212 | 50580755 |
Thrombosis prophylaxis | 13.84 | 12.80 | 3 | 23154 | 21 | 50581946 |
CSF white blood cell count decreased | 13.84 | 12.80 | 3 | 23154 | 21 | 50581946 |
Insomnia | 13.76 | 12.80 | 38 | 23119 | 174827 | 50407140 |
Mucosal inflammation | 13.70 | 12.80 | 45 | 23112 | 40097 | 50541870 |
Gestational diabetes | 13.70 | 12.80 | 17 | 23140 | 7448 | 50574519 |
Clostridium difficile colitis | 13.57 | 12.80 | 27 | 23130 | 17715 | 50564252 |
Foetal growth abnormality | 13.49 | 12.80 | 3 | 23154 | 24 | 50581943 |
Humerus fracture | 13.43 | 12.80 | 17 | 23140 | 7601 | 50574366 |
Red cell distribution width increased | 13.37 | 12.80 | 18 | 23139 | 8541 | 50573426 |
Cholelithiasis | 13.35 | 12.80 | 43 | 23114 | 37930 | 50544037 |
Rash | 13.32 | 12.80 | 132 | 23025 | 437339 | 50144628 |
Anxiety disorder | 13.27 | 12.80 | 12 | 23145 | 3661 | 50578306 |
Injection site erythema | 13.27 | 12.80 | 9 | 23148 | 74927 | 50507040 |
Transaminases increased | 13.14 | 12.80 | 35 | 23122 | 27789 | 50554178 |
Asthma | 13.00 | 12.80 | 13 | 23144 | 89324 | 50492643 |
HER2 positive breast cancer | 12.94 | 12.80 | 5 | 23152 | 306 | 50581661 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Appendicolith | 188.97 | 13.67 | 77 | 21336 | 3403 | 29549711 |
General physical health deterioration | 159.66 | 13.67 | 275 | 21138 | 102582 | 29450532 |
Appendicitis | 126.56 | 13.67 | 79 | 21334 | 8700 | 29544414 |
Drug ineffective | 103.88 | 13.67 | 68 | 21345 | 363102 | 29190012 |
Cardiogenic shock | 97.85 | 13.67 | 93 | 21320 | 19097 | 29534017 |
Pulmonary embolism | 96.27 | 13.67 | 187 | 21226 | 76347 | 29476767 |
Hepatocellular injury | 77.52 | 13.67 | 86 | 21327 | 21157 | 29531957 |
Toxic epidermal necrolysis | 75.93 | 13.67 | 79 | 21334 | 18074 | 29535040 |
Sepsis | 66.05 | 13.67 | 240 | 21173 | 142442 | 29410672 |
Stress | 63.39 | 13.67 | 78 | 21335 | 21412 | 29531702 |
Ascites | 60.73 | 13.67 | 101 | 21312 | 36518 | 29516596 |
Thrombocytopenia | 60.05 | 13.67 | 224 | 21189 | 134599 | 29418515 |
Heparin-induced thrombocytopenia | 59.90 | 13.67 | 40 | 21373 | 4939 | 29548175 |
Lymph node calcification | 59.04 | 13.67 | 15 | 21398 | 135 | 29552979 |
Acute kidney injury | 58.28 | 13.67 | 359 | 21054 | 264908 | 29288206 |
Multiple organ dysfunction syndrome | 54.96 | 13.67 | 133 | 21280 | 62983 | 29490131 |
Abdominal pain | 51.45 | 13.67 | 214 | 21199 | 135143 | 29417971 |
Abdominal distension | 49.13 | 13.67 | 105 | 21308 | 45806 | 29507308 |
Hyponatraemia | 49.02 | 13.67 | 133 | 21280 | 67500 | 29485614 |
Toxicity to various agents | 46.17 | 13.67 | 35 | 21378 | 173626 | 29379488 |
Drug abuse | 43.22 | 13.67 | 4 | 21409 | 79879 | 29473235 |
Haemorrhage | 37.11 | 13.67 | 93 | 21320 | 44979 | 29508135 |
Pulmonary sarcoidosis | 36.82 | 13.67 | 14 | 21399 | 513 | 29552601 |
Aplasia | 35.81 | 13.67 | 27 | 21386 | 4036 | 29549078 |
Death | 32.29 | 13.67 | 133 | 21280 | 341951 | 29211163 |
Suspected product quality issue | 31.29 | 13.67 | 9 | 21404 | 134 | 29552980 |
Neutropenia | 30.52 | 13.67 | 181 | 21232 | 131530 | 29421584 |
Hepatic haematoma | 29.44 | 13.67 | 11 | 21402 | 384 | 29552730 |
Ventricular fibrillation | 29.41 | 13.67 | 46 | 21367 | 15787 | 29537327 |
Bronchial obstruction | 29.26 | 13.67 | 16 | 21397 | 1375 | 29551739 |
Bronchial disorder | 29.07 | 13.67 | 15 | 21398 | 1146 | 29551968 |
Product dose omission issue | 28.84 | 13.67 | 17 | 21396 | 96366 | 29456748 |
Feeling abnormal | 28.72 | 13.67 | 3 | 21410 | 54442 | 29498672 |
Dizziness | 28.63 | 13.67 | 59 | 21354 | 189625 | 29363489 |
Splenic vein thrombosis | 28.50 | 13.67 | 11 | 21402 | 420 | 29552694 |
Haematemesis | 28.28 | 13.67 | 58 | 21355 | 24568 | 29528546 |
Peritoneal haematoma | 27.96 | 13.67 | 7 | 21406 | 59 | 29553055 |
Mucosal inflammation | 27.92 | 13.67 | 67 | 21346 | 31528 | 29521586 |
Febrile neutropenia | 27.13 | 13.67 | 156 | 21257 | 112084 | 29441030 |
Cholestasis | 26.64 | 13.67 | 55 | 21358 | 23407 | 29529707 |
Shock haemorrhagic | 25.50 | 13.67 | 33 | 21380 | 9518 | 29543596 |
Cardiac failure congestive | 25.13 | 13.67 | 12 | 21401 | 76569 | 29476545 |
Chondrocalcinosis | 24.85 | 13.67 | 9 | 21404 | 287 | 29552827 |
Floppy infant | 24.23 | 13.67 | 7 | 21406 | 106 | 29553008 |
Oesophagitis | 24.06 | 13.67 | 36 | 21377 | 11887 | 29541227 |
Genitalia external ambiguous | 23.75 | 13.67 | 8 | 21405 | 205 | 29552909 |
Septic shock | 22.99 | 13.67 | 98 | 21315 | 62462 | 29490652 |
Metastatic malignant melanoma | 22.84 | 13.67 | 15 | 21398 | 1800 | 29551314 |
Depression | 22.80 | 13.67 | 17 | 21396 | 85130 | 29467984 |
Portal vein thrombosis | 22.75 | 13.67 | 19 | 21394 | 3290 | 29549824 |
Mucosal disorder | 22.71 | 13.67 | 14 | 21399 | 1506 | 29551608 |
Muscle haemorrhage | 22.48 | 13.67 | 19 | 21394 | 3343 | 29549771 |
Hyperkalaemia | 22.43 | 13.67 | 96 | 21317 | 61296 | 29491818 |
Haemorrhagic disorder | 22.41 | 13.67 | 10 | 21403 | 553 | 29552561 |
Rash maculo-papular | 21.99 | 13.67 | 52 | 21361 | 24237 | 29528877 |
Embolism | 21.91 | 13.67 | 26 | 21387 | 6870 | 29546244 |
Congenital bladder anomaly | 21.80 | 13.67 | 8 | 21405 | 265 | 29552849 |
Hypertrophic osteoarthropathy | 21.61 | 13.67 | 6 | 21407 | 78 | 29553036 |
Lung cancer metastatic | 21.10 | 13.67 | 16 | 21397 | 2411 | 29550703 |
Pancytopenia | 21.01 | 13.67 | 117 | 21296 | 83051 | 29470063 |
Eosinophil percentage decreased | 20.52 | 13.67 | 6 | 21407 | 95 | 29553019 |
Haematoma | 20.26 | 13.67 | 49 | 21364 | 23163 | 29529951 |
Foetal hypokinesia | 19.28 | 13.67 | 8 | 21405 | 370 | 29552744 |
Coagulation factor VII level decreased | 19.26 | 13.67 | 6 | 21407 | 119 | 29552995 |
Klebsiella infection | 19.01 | 13.67 | 25 | 21388 | 7324 | 29545790 |
Compartment syndrome | 18.79 | 13.67 | 15 | 21398 | 2437 | 29550677 |
Jaundice cholestatic | 18.76 | 13.67 | 19 | 21394 | 4207 | 29548907 |
Prothrombin time shortened | 18.69 | 13.67 | 12 | 21401 | 1386 | 29551728 |
Neonatal respiratory depression | 18.61 | 13.67 | 8 | 21405 | 404 | 29552710 |
Thrombocytosis | 18.52 | 13.67 | 17 | 21396 | 3336 | 29549778 |
Pulmonary artery thrombosis | 18.50 | 13.67 | 9 | 21404 | 606 | 29552508 |
Respiratory disorder neonatal | 18.48 | 13.67 | 12 | 21401 | 1413 | 29551701 |
Bladder tamponade | 17.73 | 13.67 | 8 | 21405 | 454 | 29552660 |
Insomnia | 17.67 | 13.67 | 23 | 21390 | 88738 | 29464376 |
Pyrexia | 17.23 | 13.67 | 298 | 21115 | 287324 | 29265790 |
Blood pressure diastolic increased | 17.15 | 13.67 | 17 | 21396 | 3669 | 29549445 |
Haemolytic anaemia | 16.98 | 13.67 | 27 | 21386 | 9392 | 29543722 |
Neutropenic infection | 16.93 | 13.67 | 11 | 21402 | 1296 | 29551818 |
Cardiac flutter | 16.75 | 13.67 | 12 | 21401 | 1658 | 29551456 |
Butterfly rash | 16.30 | 13.67 | 5 | 21408 | 94 | 29553020 |
Wrong strength | 16.15 | 13.67 | 5 | 21408 | 97 | 29553017 |
Epistaxis | 16.00 | 13.67 | 77 | 21336 | 51627 | 29501487 |
Hypokalaemia | 15.71 | 13.67 | 75 | 21338 | 50128 | 29502986 |
Lung disorder | 15.65 | 13.67 | 53 | 21360 | 30309 | 29522805 |
Therapeutic product effect prolonged | 15.40 | 13.67 | 6 | 21407 | 235 | 29552879 |
Abdominal sepsis | 15.26 | 13.67 | 9 | 21404 | 893 | 29552221 |
Myositis | 15.24 | 13.67 | 27 | 21386 | 10256 | 29542858 |
Hepatic cytolysis | 15.15 | 13.67 | 24 | 21389 | 8323 | 29544791 |
Anxiety | 15.14 | 13.67 | 24 | 21389 | 85341 | 29467773 |
Gamma-glutamyltransferase increased | 14.97 | 13.67 | 48 | 21365 | 26689 | 29526425 |
Vomiting | 14.96 | 13.67 | 226 | 21187 | 212034 | 29341080 |
Constipation | 14.95 | 13.67 | 137 | 21276 | 114023 | 29439091 |
Myalgia | 14.92 | 13.67 | 19 | 21394 | 74000 | 29479114 |
Malignant neoplasm progression | 14.88 | 13.67 | 98 | 21315 | 73761 | 29479353 |
Product communication issue | 14.81 | 13.67 | 5 | 21408 | 129 | 29552985 |
Therapeutic product effect incomplete | 14.78 | 13.67 | 5 | 21408 | 39300 | 29513814 |
Respiratory tract infection | 14.70 | 13.67 | 34 | 21379 | 15617 | 29537497 |
Reading disorder | 14.68 | 13.67 | 7 | 21406 | 451 | 29552663 |
Cerebral haemorrhage | 14.59 | 13.67 | 53 | 21360 | 31373 | 29521741 |
Large intestine perforation | 14.54 | 13.67 | 22 | 21391 | 7334 | 29545780 |
Miosis | 14.50 | 13.67 | 23 | 21390 | 7986 | 29545128 |
Penile necrosis | 14.48 | 13.67 | 4 | 21409 | 51 | 29553063 |
Lower respiratory tract infection | 14.31 | 13.67 | 47 | 21366 | 26455 | 29526659 |
Hyperthermia | 14.28 | 13.67 | 25 | 21388 | 9405 | 29543709 |
Hepatitis cholestatic | 14.17 | 13.67 | 21 | 21392 | 6872 | 29546242 |
Haemoglobin decreased | 14.16 | 13.67 | 130 | 21283 | 108245 | 29444869 |
Leukopenia | 14.15 | 13.67 | 78 | 21335 | 55125 | 29497989 |
Soft tissue sarcoma | 14.13 | 13.67 | 4 | 21409 | 56 | 29553058 |
Lactic acidosis | 14.03 | 13.67 | 51 | 21362 | 30196 | 29522918 |
Hospitalisation | 13.90 | 13.67 | 8 | 21405 | 45980 | 29507134 |
Headache | 13.77 | 13.67 | 72 | 21341 | 173935 | 29379179 |
Agranulocytosis | 13.72 | 13.67 | 39 | 21374 | 20301 | 29532813 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pulmonary embolism | 267.59 | 11.64 | 395 | 40971 | 145961 | 64311405 |
General physical health deterioration | 234.82 | 11.64 | 448 | 40918 | 203977 | 64253389 |
Drug ineffective | 198.90 | 11.64 | 150 | 41216 | 840097 | 63617269 |
Appendicolith | 198.19 | 11.64 | 77 | 41289 | 3392 | 64453974 |
Hepatocellular injury | 196.40 | 11.64 | 190 | 41176 | 45045 | 64412321 |
Toxic epidermal necrolysis | 176.37 | 11.64 | 164 | 41202 | 37002 | 64420364 |
Acute kidney injury | 149.28 | 11.64 | 626 | 40740 | 448614 | 64008752 |
Thrombocytopenia | 145.11 | 11.64 | 391 | 40975 | 223410 | 64233956 |
Heparin-induced thrombocytopenia | 137.91 | 11.64 | 79 | 41287 | 8400 | 64448966 |
Appendicitis | 106.24 | 11.64 | 80 | 41286 | 13489 | 64443877 |
Sepsis | 96.67 | 11.64 | 346 | 41020 | 229995 | 64227371 |
Cholestasis | 94.93 | 11.64 | 130 | 41236 | 44742 | 64412624 |
Ascites | 85.10 | 11.64 | 147 | 41219 | 61854 | 64395512 |
Cardiogenic shock | 84.28 | 11.64 | 104 | 41262 | 32323 | 64425043 |
Toxicity to various agents | 81.68 | 11.64 | 68 | 41298 | 363445 | 64093921 |
Multiple organ dysfunction syndrome | 73.60 | 11.64 | 185 | 41181 | 101228 | 64356138 |
Drug intolerance | 70.40 | 11.64 | 17 | 41349 | 187975 | 64269391 |
Arthralgia | 68.87 | 11.64 | 111 | 41255 | 442149 | 64015217 |
Drug abuse | 68.76 | 11.64 | 4 | 41362 | 132370 | 64324996 |
Anaemia | 65.42 | 11.64 | 441 | 40925 | 378239 | 64079127 |
Product dose omission issue | 63.11 | 11.64 | 23 | 41343 | 194724 | 64262642 |
Rash maculo-papular | 61.28 | 11.64 | 109 | 41257 | 46917 | 64410449 |
Deep vein thrombosis | 60.38 | 11.64 | 176 | 41190 | 105006 | 64352360 |
Neutropenia | 57.33 | 11.64 | 304 | 41062 | 239320 | 64218046 |
Lymph node calcification | 53.96 | 11.64 | 16 | 41350 | 303 | 64457063 |
Arthropathy | 53.80 | 11.64 | 7 | 41359 | 120960 | 64336406 |
Therapeutic product effect decreased | 52.96 | 11.64 | 6 | 41360 | 115345 | 64342021 |
Abdominal pain | 51.64 | 11.64 | 360 | 41006 | 312015 | 64145351 |
Febrile neutropenia | 51.13 | 11.64 | 247 | 41119 | 187410 | 64269956 |
Headache | 50.92 | 11.64 | 172 | 41194 | 529295 | 63928071 |
Gamma-glutamyltransferase increased | 49.10 | 11.64 | 101 | 41265 | 48409 | 64408957 |
Haematoma | 48.84 | 11.64 | 98 | 41268 | 46152 | 64411214 |
Neutropenic sepsis | 48.57 | 11.64 | 67 | 41299 | 23205 | 64434161 |
Malignant neoplasm progression | 48.50 | 11.64 | 171 | 41195 | 112700 | 64344666 |
Hyperkalaemia | 45.87 | 11.64 | 156 | 41210 | 100973 | 64356393 |
Depression | 45.32 | 11.64 | 31 | 41335 | 183260 | 64274106 |
Embolism | 45.00 | 11.64 | 47 | 41319 | 12188 | 64445178 |
Pancytopenia | 44.47 | 11.64 | 196 | 41170 | 143113 | 64314253 |
Constipation | 44.37 | 11.64 | 275 | 41091 | 229062 | 64228304 |
Sinusitis | 44.36 | 11.64 | 19 | 41347 | 145909 | 64311457 |
Abdominal discomfort | 43.55 | 11.64 | 32 | 41334 | 182290 | 64275076 |
Drug reaction with eosinophilia and systemic symptoms | 42.60 | 11.64 | 102 | 41264 | 54115 | 64403251 |
Blood loss anaemia | 41.76 | 11.64 | 48 | 41318 | 13844 | 64443522 |
Abdominal distension | 41.72 | 11.64 | 146 | 41220 | 95848 | 64361518 |
Epistaxis | 41.58 | 11.64 | 148 | 41218 | 97983 | 64359383 |
Cardiac failure congestive | 41.32 | 11.64 | 16 | 41350 | 130564 | 64326802 |
Feeling abnormal | 41.25 | 11.64 | 17 | 41349 | 133585 | 64323781 |
Blue toe syndrome | 40.88 | 11.64 | 15 | 41351 | 563 | 64456803 |
Agranulocytosis | 40.36 | 11.64 | 81 | 41285 | 38148 | 64419218 |
Haemoglobin decreased | 40.32 | 11.64 | 238 | 41128 | 194825 | 64262541 |
Biliary sepsis | 39.53 | 11.64 | 19 | 41347 | 1409 | 64455957 |
Joint swelling | 39.50 | 11.64 | 48 | 41318 | 215334 | 64242032 |
Haemorrhage | 39.19 | 11.64 | 126 | 41240 | 79225 | 64378141 |
Rheumatoid arthritis | 39.03 | 11.64 | 29 | 41337 | 164265 | 64293101 |
Hyperthyroidism | 38.93 | 11.64 | 53 | 41313 | 18126 | 64439240 |
Jaundice | 38.90 | 11.64 | 92 | 41274 | 48420 | 64408946 |
Muscle haemorrhage | 38.68 | 11.64 | 31 | 41335 | 5722 | 64451644 |
Pyrexia | 38.58 | 11.64 | 536 | 40830 | 558108 | 63899258 |
Blood creatine increased | 38.55 | 11.64 | 36 | 41330 | 8156 | 64449210 |
Melaena | 38.11 | 11.64 | 97 | 41269 | 53451 | 64403915 |
Arteriovenous fistula occlusion | 37.92 | 11.64 | 14 | 41352 | 535 | 64456831 |
Cerebral haemorrhage | 37.88 | 11.64 | 94 | 41272 | 50996 | 64406370 |
Shock haemorrhagic | 37.56 | 11.64 | 50 | 41316 | 16741 | 64440625 |
Vessel puncture site bruise | 37.55 | 11.64 | 13 | 41353 | 411 | 64456955 |
Venous pressure jugular decreased | 36.40 | 11.64 | 9 | 41357 | 82 | 64457284 |
Hepatitis cholestatic | 34.87 | 11.64 | 41 | 41325 | 12114 | 64445252 |
Ovarian hyperstimulation syndrome | 34.60 | 11.64 | 22 | 41344 | 2823 | 64454543 |
Aplasia | 33.58 | 11.64 | 31 | 41335 | 6922 | 64450444 |
Musculoskeletal stiffness | 32.98 | 11.64 | 19 | 41347 | 123187 | 64334179 |
Discomfort | 32.95 | 11.64 | 6 | 41360 | 80872 | 64376494 |
Treatment failure | 32.75 | 11.64 | 17 | 41349 | 116799 | 64340567 |
Hyponatraemia | 32.60 | 11.64 | 184 | 41182 | 148155 | 64309211 |
Therapeutic product effect incomplete | 32.21 | 11.64 | 13 | 41353 | 103469 | 64353897 |
Pituitary tumour | 31.48 | 11.64 | 15 | 41351 | 1091 | 64456275 |
Pulmonary sarcoidosis | 31.17 | 11.64 | 15 | 41351 | 1116 | 64456250 |
Body dysmorphic disorder | 31.14 | 11.64 | 10 | 41356 | 249 | 64457117 |
Dizziness | 31.12 | 11.64 | 156 | 41210 | 430007 | 64027359 |
Mucosal inflammation | 30.56 | 11.64 | 99 | 41267 | 62485 | 64394881 |
Thrombosis | 30.31 | 11.64 | 107 | 41259 | 70535 | 64386831 |
Neoplasm progression | 29.97 | 11.64 | 75 | 41291 | 40889 | 64416477 |
Haematemesis | 29.24 | 11.64 | 81 | 41285 | 46918 | 64410448 |
Systemic lupus erythematosus | 29.07 | 11.64 | 7 | 41359 | 77605 | 64379761 |
Adrenal suppression | 28.89 | 11.64 | 15 | 41351 | 1312 | 64456054 |
Phlebitis | 28.86 | 11.64 | 30 | 41336 | 7736 | 64449630 |
Diarrhoea | 28.77 | 11.64 | 635 | 40731 | 722069 | 63735297 |
Glossodynia | 28.15 | 11.64 | 4 | 41362 | 64692 | 64392674 |
Haematoma muscle | 27.28 | 11.64 | 16 | 41350 | 1777 | 64455589 |
Fatigue | 27.07 | 11.64 | 329 | 41037 | 748401 | 63708965 |
Thrombophlebitis | 26.90 | 11.64 | 25 | 41341 | 5629 | 64451737 |
Suspected product quality issue | 26.60 | 11.64 | 9 | 41357 | 265 | 64457101 |
Dermatitis exfoliative | 26.56 | 11.64 | 33 | 41333 | 10319 | 64447047 |
Drug hypersensitivity | 26.55 | 11.64 | 72 | 41294 | 237743 | 64219623 |
Gastrointestinal haemorrhage | 26.40 | 11.64 | 160 | 41206 | 132152 | 64325214 |
Hypothalamo-pituitary disorder | 26.23 | 11.64 | 13 | 41353 | 1031 | 64456335 |
Insomnia | 25.97 | 11.64 | 55 | 41311 | 197781 | 64259585 |
Hepatic haematoma | 25.95 | 11.64 | 12 | 41354 | 816 | 64456550 |
Blood alkaline phosphatase increased | 25.67 | 11.64 | 87 | 41279 | 56192 | 64401174 |
Lung cancer metastatic | 25.66 | 11.64 | 19 | 41347 | 3121 | 64454245 |
Intra-abdominal haemorrhage | 25.58 | 11.64 | 21 | 41345 | 4010 | 64453356 |
Bronchial obstruction | 25.54 | 11.64 | 17 | 41349 | 2357 | 64455009 |
Intentional overdose | 25.34 | 11.64 | 13 | 41353 | 89931 | 64367435 |
Peritonitis | 25.20 | 11.64 | 52 | 41314 | 24971 | 64432395 |
Bronchial disorder | 24.84 | 11.64 | 16 | 41350 | 2099 | 64455267 |
Splenic vein thrombosis | 24.55 | 11.64 | 11 | 41355 | 695 | 64456671 |
Needle issue | 24.51 | 11.64 | 30 | 41336 | 9242 | 64448124 |
Alopecia | 24.41 | 11.64 | 43 | 41323 | 165647 | 64291719 |
Abdominal wall haematoma | 24.37 | 11.64 | 21 | 41345 | 4284 | 64453082 |
Retroperitoneal haemorrhage | 24.08 | 11.64 | 22 | 41344 | 4846 | 64452520 |
Infusion related reaction | 23.94 | 11.64 | 43 | 41323 | 164424 | 64292942 |
Limbal swelling | 23.93 | 11.64 | 5 | 41361 | 19 | 64457347 |
Activated partial thromboplastin time prolonged | 23.91 | 11.64 | 35 | 41331 | 12796 | 64444570 |
Pneumothorax traumatic | 23.89 | 11.64 | 8 | 41358 | 228 | 64457138 |
Hypersensitivity | 23.84 | 11.64 | 57 | 41309 | 196395 | 64260971 |
Cardiomyopathy acute | 23.70 | 11.64 | 8 | 41358 | 234 | 64457132 |
Joint ankylosis | 23.65 | 11.64 | 11 | 41355 | 758 | 64456608 |
Portal vein thrombosis | 23.61 | 11.64 | 22 | 41344 | 4969 | 64452397 |
Haemolysis | 23.36 | 11.64 | 32 | 41334 | 11007 | 64446359 |
Bone marrow eosinophilic leukocyte count increased | 23.35 | 11.64 | 5 | 41361 | 22 | 64457344 |
Clostridium difficile colitis | 23.33 | 11.64 | 53 | 41313 | 27170 | 64430196 |
Therapeutic response decreased | 23.25 | 11.64 | 3 | 41363 | 52185 | 64405181 |
Death | 23.24 | 11.64 | 198 | 41168 | 482507 | 63974859 |
Gastric antral vascular ectasia | 23.13 | 11.64 | 11 | 41355 | 797 | 64456569 |
Nasal congestion | 23.10 | 11.64 | 5 | 41361 | 59653 | 64397713 |
Oesophagitis | 23.03 | 11.64 | 46 | 41320 | 21584 | 64435782 |
Klebsiella infection | 22.99 | 11.64 | 35 | 41331 | 13246 | 64444120 |
Hepatic cytolysis | 22.89 | 11.64 | 36 | 41330 | 14013 | 64443353 |
Hypokalaemia | 22.80 | 11.64 | 145 | 41221 | 121758 | 64335608 |
Compartment syndrome | 22.66 | 11.64 | 20 | 41346 | 4212 | 64453154 |
Septic shock | 22.64 | 11.64 | 130 | 41236 | 105307 | 64352059 |
Subcutaneous haematoma | 22.51 | 11.64 | 16 | 41350 | 2467 | 64454899 |
Gait disturbance | 22.47 | 11.64 | 48 | 41318 | 172107 | 64285259 |
Perforation | 22.23 | 11.64 | 12 | 41354 | 1136 | 64456230 |
Fracture blisters | 22.19 | 11.64 | 6 | 41360 | 80 | 64457286 |
Ventricular fibrillation | 22.19 | 11.64 | 48 | 41318 | 23812 | 64433554 |
Peritoneal haematoma | 22.01 | 11.64 | 7 | 41359 | 169 | 64457197 |
Haemolytic anaemia | 21.93 | 11.64 | 38 | 41328 | 16015 | 64441351 |
Allergic hepatitis | 21.91 | 11.64 | 5 | 41361 | 31 | 64457335 |
Wound | 21.62 | 11.64 | 11 | 41355 | 76466 | 64380900 |
Hyperthermia | 21.49 | 11.64 | 37 | 41329 | 15513 | 64441853 |
Catheter site thrombosis | 21.23 | 11.64 | 7 | 41359 | 190 | 64457176 |
Leukopenia | 21.20 | 11.64 | 124 | 41242 | 101118 | 64356248 |
Asthma | 21.10 | 11.64 | 18 | 41348 | 95207 | 64362159 |
Chondrocalcinosis | 21.08 | 11.64 | 10 | 41356 | 720 | 64456646 |
Cytokine release syndrome | 20.64 | 11.64 | 43 | 41323 | 20786 | 64436580 |
Thrombocytosis | 20.30 | 11.64 | 24 | 41342 | 7132 | 64450234 |
Reading disorder | 20.06 | 11.64 | 10 | 41356 | 803 | 64456563 |
Hypertrophic osteoarthropathy | 19.88 | 11.64 | 6 | 41360 | 121 | 64457245 |
Abdominal wall haemorrhage | 19.31 | 11.64 | 8 | 41358 | 417 | 64456949 |
Upper gastrointestinal haemorrhage | 19.30 | 11.64 | 58 | 41308 | 35162 | 64422204 |
Myalgia | 19.26 | 11.64 | 46 | 41320 | 158571 | 64298795 |
Eosinophil percentage decreased | 19.07 | 11.64 | 7 | 41359 | 263 | 64457103 |
Pulmonary artery thrombosis | 18.98 | 11.64 | 11 | 41355 | 1195 | 64456171 |
Retroperitoneal haematoma | 18.96 | 11.64 | 19 | 41347 | 4692 | 64452674 |
Suicide attempt | 18.93 | 11.64 | 11 | 41355 | 70996 | 64386370 |
Livedo reticularis | 18.86 | 11.64 | 17 | 41349 | 3680 | 64453686 |
Pulmonary infarction | 18.82 | 11.64 | 16 | 41350 | 3206 | 64454160 |
Pleural effusion | 18.63 | 11.64 | 142 | 41224 | 126417 | 64330949 |
Neutropenic infection | 18.60 | 11.64 | 13 | 41353 | 1952 | 64455414 |
Ill-defined disorder | 18.53 | 11.64 | 3 | 41363 | 44049 | 64413317 |
Haemorrhagic erosive gastritis | 18.40 | 11.64 | 8 | 41358 | 470 | 64456896 |
Hospitalisation | 18.20 | 11.64 | 13 | 41353 | 75194 | 64382172 |
Pain | 18.18 | 11.64 | 248 | 41118 | 553263 | 63904103 |
Psoriatic arthropathy | 18.09 | 11.64 | 3 | 41363 | 43278 | 64414088 |
Lung disorder | 18.04 | 11.64 | 82 | 41284 | 60618 | 64396748 |
Dysgraphia | 17.79 | 11.64 | 16 | 41350 | 3455 | 64453911 |
Metastatic malignant melanoma | 17.74 | 11.64 | 14 | 41352 | 2527 | 64454839 |
Bladder tamponade | 17.65 | 11.64 | 8 | 41358 | 519 | 64456847 |
Intracranial pressure increased | 17.49 | 11.64 | 22 | 41344 | 6967 | 64450399 |
Pneumobilia | 17.44 | 11.64 | 6 | 41360 | 186 | 64457180 |
Stress | 17.42 | 11.64 | 81 | 41285 | 60453 | 64396913 |
Basilar artery occlusion | 17.17 | 11.64 | 6 | 41360 | 195 | 64457171 |
Engraftment syndrome | 17.11 | 11.64 | 10 | 41356 | 1103 | 64456263 |
Cerebral haematoma | 17.00 | 11.64 | 22 | 41344 | 7163 | 64450203 |
Coagulation factor VII level decreased | 16.94 | 11.64 | 6 | 41360 | 203 | 64457163 |
Acute polyneuropathy | 16.66 | 11.64 | 7 | 41359 | 378 | 64456988 |
Pain in jaw | 16.65 | 11.64 | 3 | 41363 | 40752 | 64416614 |
Femoral neck fracture | 16.55 | 11.64 | 24 | 41342 | 8700 | 64448666 |
Rectal haemorrhage | 16.54 | 11.64 | 81 | 41285 | 61736 | 64395630 |
Injection site pain | 16.32 | 11.64 | 29 | 41337 | 111379 | 64345987 |
Hypovolaemic shock | 16.30 | 11.64 | 26 | 41340 | 10240 | 64447126 |
Transaminases increased | 16.17 | 11.64 | 64 | 41302 | 44530 | 64412836 |
Antinuclear antibody positive | 16.16 | 11.64 | 20 | 41346 | 6230 | 64451136 |
Treatment noncompliance | 16.13 | 11.64 | 4 | 41362 | 43478 | 64413888 |
International normalised ratio increased | 15.95 | 11.64 | 96 | 41270 | 79071 | 64378295 |
Anaemia folate deficiency | 15.89 | 11.64 | 6 | 41360 | 244 | 64457122 |
Varices oesophageal | 15.88 | 11.64 | 18 | 41348 | 5112 | 64452254 |
Vomiting | 15.87 | 11.64 | 464 | 40902 | 550653 | 63906713 |
Overdose | 15.85 | 11.64 | 51 | 41315 | 159515 | 64297851 |
Febrile bone marrow aplasia | 15.84 | 11.64 | 27 | 41339 | 11228 | 64446138 |
Erysipelas | 15.81 | 11.64 | 24 | 41342 | 9057 | 64448309 |
Alanine aminotransferase increased | 15.70 | 11.64 | 147 | 41219 | 138884 | 64318482 |
Intentional product misuse | 15.61 | 11.64 | 14 | 41352 | 72281 | 64385085 |
Cardiac failure | 15.47 | 11.64 | 141 | 41225 | 132232 | 64325134 |
Adverse drug reaction | 15.35 | 11.64 | 5 | 41361 | 45459 | 64411907 |
Penile necrosis | 15.34 | 11.64 | 4 | 41362 | 46 | 64457320 |
Myositis | 15.29 | 11.64 | 33 | 41333 | 16344 | 64441022 |
Balance disorder | 15.06 | 11.64 | 19 | 41347 | 83907 | 64373459 |
Weight increased | 15.03 | 11.64 | 78 | 41288 | 213270 | 64244096 |
Haemorrhagic disorder | 15.01 | 11.64 | 10 | 41356 | 1389 | 64455977 |
Injection site erythema | 14.95 | 11.64 | 14 | 41352 | 70786 | 64386580 |
Exposure during pregnancy | 14.90 | 11.64 | 93 | 41273 | 77582 | 64379784 |
Mobility decreased | 14.82 | 11.64 | 20 | 41346 | 85820 | 64371546 |
International normalised ratio decreased | 14.81 | 11.64 | 21 | 41345 | 7457 | 64449909 |
Erythema | 14.71 | 11.64 | 184 | 41182 | 186886 | 64270480 |
Influenza like illness | 14.50 | 11.64 | 11 | 41355 | 61691 | 64395675 |
Blood cholesterol increased | 14.46 | 11.64 | 7 | 41359 | 50059 | 64407307 |
Mean cell volume increased | 14.44 | 11.64 | 17 | 41349 | 5029 | 64452337 |
Peripheral swelling | 14.44 | 11.64 | 77 | 41289 | 209076 | 64248290 |
Cholecystitis | 14.41 | 11.64 | 36 | 41330 | 19600 | 64437766 |
Lordosis | 14.30 | 11.64 | 6 | 41360 | 323 | 64457043 |
Wrong strength | 14.30 | 11.64 | 5 | 41361 | 163 | 64457203 |
Granulocyte count increased | 14.25 | 11.64 | 8 | 41358 | 818 | 64456548 |
Magnetic resonance imaging head abnormal | 14.13 | 11.64 | 12 | 41354 | 2400 | 64454966 |
Protein C decreased | 14.12 | 11.64 | 4 | 41362 | 64 | 64457302 |
Viral infection | 14.05 | 11.64 | 3 | 41363 | 36137 | 64421229 |
Psychiatric decompensation | 13.91 | 11.64 | 12 | 41354 | 2451 | 64454915 |
Chemotherapeutic drug level increased | 13.91 | 11.64 | 6 | 41360 | 346 | 64457020 |
Jaundice cholestatic | 13.82 | 11.64 | 22 | 41344 | 8648 | 64448718 |
Pain in extremity | 13.81 | 11.64 | 126 | 41240 | 302959 | 64154407 |
Migraine | 13.70 | 11.64 | 12 | 41354 | 62665 | 64394701 |
Drug interaction | 13.65 | 11.64 | 316 | 41050 | 361767 | 64095599 |
Influenza | 13.65 | 11.64 | 30 | 41336 | 106501 | 64350865 |
Drug resistance | 13.47 | 11.64 | 3 | 41363 | 35099 | 64422267 |
Loss of personal independence in daily activities | 13.42 | 11.64 | 16 | 41350 | 72438 | 64384928 |
Lactic acidosis | 13.36 | 11.64 | 76 | 41290 | 61334 | 64396032 |
Respiratory disorder | 13.23 | 11.64 | 52 | 41314 | 36059 | 64421307 |
Duodenal ulcer perforation | 13.21 | 11.64 | 3 | 41363 | 34622 | 64422744 |
Unevaluable event | 13.20 | 11.64 | 8 | 41358 | 50481 | 64406885 |
Sudden hearing loss | 13.20 | 11.64 | 10 | 41356 | 1700 | 64455666 |
Staphylococcal scalded skin syndrome | 13.17 | 11.64 | 6 | 41360 | 394 | 64456972 |
Injury | 13.13 | 11.64 | 10 | 41356 | 55982 | 64401384 |
Blood creatinine increased | 13.11 | 11.64 | 139 | 41227 | 135643 | 64321723 |
Thrombosis prophylaxis | 13.09 | 11.64 | 3 | 41363 | 19 | 64457347 |
Suicidal ideation | 13.08 | 11.64 | 14 | 41352 | 66528 | 64390838 |
Mental status changes | 13.02 | 11.64 | 12 | 41354 | 61150 | 64396216 |
Disseminated intravascular coagulation | 13.02 | 11.64 | 48 | 41318 | 32300 | 64425066 |
Respiratory distress | 12.89 | 11.64 | 67 | 41299 | 52264 | 64405102 |
Visual acuity reduced transiently | 12.87 | 11.64 | 5 | 41361 | 220 | 64457146 |
Protein S decreased | 12.84 | 11.64 | 4 | 41362 | 90 | 64457276 |
Hyperlipasaemia | 12.76 | 11.64 | 8 | 41358 | 1002 | 64456364 |
Gastrointestinal stoma output increased | 12.68 | 11.64 | 5 | 41361 | 229 | 64457137 |
Eosinophilia | 12.50 | 11.64 | 53 | 41313 | 38023 | 64419343 |
CSF white blood cell count decreased | 12.48 | 11.64 | 3 | 41363 | 24 | 64457342 |
Post procedural pulmonary embolism | 12.46 | 11.64 | 5 | 41361 | 240 | 64457126 |
Electrolyte imbalance | 12.38 | 11.64 | 40 | 41326 | 25203 | 64432163 |
Prostatitis Escherichia coli | 12.37 | 11.64 | 3 | 41363 | 25 | 64457341 |
IIIrd nerve disorder | 12.37 | 11.64 | 4 | 41362 | 102 | 64457264 |
Superior vena cava syndrome | 12.30 | 11.64 | 8 | 41358 | 1067 | 64456299 |
Injection site bruising | 12.28 | 11.64 | 4 | 41362 | 36369 | 64420997 |
Haemoptysis | 12.22 | 11.64 | 63 | 41303 | 48985 | 64408381 |
Swelling | 12.19 | 11.64 | 57 | 41309 | 160161 | 64297205 |
Gastrointestinal tract adenoma | 12.18 | 11.64 | 6 | 41360 | 470 | 64456896 |
Throat irritation | 12.15 | 11.64 | 3 | 41363 | 32708 | 64424658 |
Soft tissue sarcoma | 12.12 | 11.64 | 4 | 41362 | 109 | 64457257 |
Emotional distress | 12.10 | 11.64 | 4 | 41362 | 36034 | 64421332 |
HER2 positive breast cancer | 12.04 | 11.64 | 5 | 41361 | 262 | 64457104 |
Therapy cessation | 12.03 | 11.64 | 3 | 41363 | 32486 | 64424880 |
Nasopharyngitis | 12.02 | 11.64 | 75 | 41291 | 195998 | 64261368 |
Faecaloma | 11.97 | 11.64 | 22 | 41344 | 9706 | 64447660 |
Renal tubular acidosis | 11.96 | 11.64 | 12 | 41354 | 2967 | 64454399 |
Malnutrition | 11.93 | 11.64 | 33 | 41333 | 19092 | 64438274 |
Interstitial lung disease | 11.87 | 11.64 | 105 | 41261 | 97627 | 64359739 |
Intra-abdominal haematoma | 11.87 | 11.64 | 11 | 41355 | 2468 | 64454898 |
Fall | 11.85 | 11.64 | 192 | 41174 | 416634 | 64040732 |
Reticulocyte count increased | 11.72 | 11.64 | 8 | 41358 | 1156 | 64456210 |
Gastrointestinal disorder | 11.71 | 11.64 | 25 | 41341 | 89684 | 64367682 |
Gastrointestinal ulcer perforation | 11.71 | 11.64 | 3 | 41363 | 32 | 64457334 |
None
Source | Code | Description |
---|---|---|
ATC | B01AB10 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group |
ATC | B01AB12 | BLOOD AND BLOOD FORMING ORGANS ANTITHROMBOTIC AGENTS ANTITHROMBOTIC AGENTS Heparin group |
FDA CS | M0010191 | Heparin, Low-Molecular-Weight |
FDA EPC | N0000175586 | Low Molecular Weight Heparin |
MeSH PA | D000925 | Anticoagulants |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D005343 | Fibrinolytic Agents |
MeSH PA | D006401 | Hematologic Agents |
CHEBI has role | CHEBI:50249 | anticoagulants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pulmonary embolism | indication | 59282003 | DOID:9477 |
Deep venous thrombosis | indication | 128053003 |
None
None
None
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10,000IU/0.4ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | May 1, 2007 | DISCN | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
10,000IU/ML (10,000IU/ML) | FRAGMIN | PFIZER | N020287 | Jan. 30, 1998 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
12,500IU/0.5ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | May 1, 2007 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
15,000IU/0.6ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | May 1, 2007 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
18,000IU/0.72ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | May 1, 2007 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
2,500IU/0.2ML (12,500IU/ML) | FRAGMIN | PFIZER | N020287 | Dec. 22, 1994 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
5,000IU/0.2ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | March 18, 1996 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
7,500 IU/0.75ML | FRAGMIN | PFIZER | N020287 | April 4, 2002 | DISCN | INJECTABLE | INJECTION | May 16, 2022 | NEW PATIENT POPULATION |
7,500IU/0.3ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | April 4, 2002 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
95,000IU/3.8ML (25,000IU/ML) | FRAGMIN | PFIZER | N020287 | April 4, 2002 | RX | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
95,000IU/9.5ML (10,000IU/ML) | FRAGMIN | PFIZER | N020287 | April 4, 2002 | DISCN | INJECTABLE | SUBCUTANEOUS | May 16, 2022 | NEW PATIENT POPULATION |
None
ID | Source |
---|---|
PUE0TO3XDR | UNII |
4020894 | VANDF |
4021054 | VANDF |
4021237 | VANDF |
4024199 | VANDF |
C0916062 | UMLSCUI |
CHEBI:28304 | CHEBI |
CHEMBL3707365 | ChEMBL_ID |
772 | PUBCHEM_CID |
DB09258 | DRUGBANK_ID |
CHEMBL4650299 | ChEMBL_ID |
CHEMBL1201414 | ChEMBL_ID |
CHEMBL1201448 | ChEMBL_ID |
CHEMBL1201460 | ChEMBL_ID |
CHEMBL2108806 | ChEMBL_ID |
C411345 | MESH_SUPPLEMENTAL_RECORD_UI |
C093450 | MESH_SUPPLEMENTAL_RECORD_UI |
6846 | IUPHAR_LIGAND_ID |
9005-49-6 | SECONDARY_CAS_RN |
DB06822 | DRUGBANK_ID |
104466 | RXNORM |
15471 | MMSL |
4531 | MMSL |
d04659 | MMSL |
005078 | NDDF |
007911 | NDDF |
008338 | NDDF |
108987000 | SNOMEDCT_US |
108990006 | SNOMEDCT_US |
350469004 | SNOMEDCT_US |
395908006 | SNOMEDCT_US |
410964003 | SNOMEDCT_US |
410965002 | SNOMEDCT_US |
410967005 | SNOMEDCT_US |
412608008 | SNOMEDCT_US |
D000078222 | MESH_DESCRIPTOR_UI |
D017985 | MESH_DESCRIPTOR_UI |
6985 | INN_ID |
5688 | INN_ID |
6764 | INN_ID |
7501 | INN_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0195 | INJECTION | 2500 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0196 | INJECTION | 5000 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0206 | INJECTION | 7500 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0217 | INJECTION | 10000 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0220 | INJECTION | 12500 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0223 | INJECTION | 15000 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0228 | INJECTION | 18000 [iU] | SUBCUTANEOUS | NDA | 28 sections |
Fragmin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0232 | INJECTION | 25000 [iU] | SUBCUTANEOUS | NDA | 28 sections |