bemiparin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
heparin derivatives including low molecular mass heparins 4840 9041-08-1

Description:

MoleculeDescription

Synonyms:

  • tinzaparin
  • ardeparin sodium
  • dalteparin sodium
  • tinzaparin sodium
  • bemiparin
  • bemiparin sodium
A low-molecular-weight fragment of heparin, prepared by nitrous acid depolymerization of porcine mucosal heparin. The mean molecular weight is 4000-6000 daltons. It is used therapeutically as an antithrombotic agent. (From Merck Index, 11th ed)
  • Molecular weight:
  • Formula: None
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.50 TU P
2.50 TU P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Dec. 22, 1994 FDA PFIZER INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary embolism 296.89 13.27 295 31996 130525 90465631
Acute kidney injury 241.44 13.27 419 31872 319968 90276188
Thrombocytopenia 210.65 13.27 312 31979 208413 90387743
Toxic epidermal necrolysis 176.96 13.27 122 32169 32406 90563750
Anaemia 165.97 13.27 379 31912 352423 90243733
Hepatocellular injury 163.17 13.27 111 32180 28847 90567309
Drug ineffective 150.34 13.27 164 32127 1384134 89212022
Heparin-induced thrombocytopenia 142.44 13.27 58 32233 5254 90590902
Needle issue 130.97 13.27 74 32217 13860 90582296
Arthropathy 106.26 13.27 6 32285 366236 90229920
Cholestasis 103.50 13.27 93 32198 36206 90559950
Glossodynia 100.91 13.27 3 32288 321776 90274380
Deep vein thrombosis 99.59 13.27 142 32149 91478 90504678
Febrile neutropenia 96.18 13.27 189 32102 158160 90437996
Arthralgia 96.05 13.27 82 32209 778440 89817716
Premature baby 95.70 13.27 76 32215 25001 90571155
Systemic lupus erythematosus 93.60 13.27 10 32281 361886 90234270
Rheumatoid arthritis 91.32 13.27 11 32280 362603 90233553
Activated partial thromboplastin time prolonged 88.58 13.27 47 32244 7778 90588378
Cytokine release syndrome 88.43 13.27 76 32215 27897 90568259
Neutropenic sepsis 84.72 13.27 62 32229 18068 90578088
Abdominal discomfort 83.25 13.27 33 32258 477295 90118861
Pericarditis 82.99 13.27 3 32288 270148 90326008
Therapeutic product effect decreased 82.21 13.27 4 32287 277567 90318589
Abdominal wall haematoma 81.07 13.27 34 32257 3318 90592838
Pancytopenia 80.97 13.27 150 32141 120113 90476043
Sinusitis 80.29 13.27 13 32278 343075 90253081
Joint swelling 79.62 13.27 40 32251 503260 90092896
Discomfort 78.02 13.27 5 32286 274330 90321826
Drug intolerance 77.96 13.27 31 32260 447560 90148596
Haematoma muscle 77.64 13.27 28 32263 1822 90594334
Premature delivery 76.17 13.27 81 32210 38681 90557475
Blood creatinine increased 75.32 13.27 132 32159 101254 90494902
General physical health deterioration 74.99 13.27 287 32004 354828 90241328
Wound 74.31 13.27 10 32281 302970 90293186
Hepatic cytolysis 72.37 13.27 71 32220 30845 90565311
Haemoglobin decreased 71.58 13.27 170 32121 161786 90434370
Agranulocytosis 70.30 13.27 74 32217 34928 90561228
Sepsis 70.22 13.27 180 32111 179634 90416522
Neutropenia 68.88 13.27 206 32085 224698 90371458
Haematoma 68.72 13.27 77 32214 38971 90557185
Psoriatic arthropathy 68.55 13.27 3 32288 228332 90367824
Treatment failure 67.87 13.27 13 32278 303915 90292241
Jaundice 67.55 13.27 70 32221 32447 90563709
Alopecia 67.49 13.27 47 32244 495024 90101132
Impaired healing 67.39 13.27 4 32287 234195 90361961
Ascites 67.23 13.27 84 32207 47656 90548500
Drug reaction with eosinophilia and systemic symptoms 66.32 13.27 79 32212 42679 90553477
Drug interaction 64.67 13.27 231 32060 276222 90319934
Thrombosis 63.22 13.27 102 32189 73149 90523007
Rash maculo-papular 60.82 13.27 74 32217 40859 90555297
Constipation 60.29 13.27 228 32063 280167 90315989
Product dose omission issue 60.02 13.27 15 32276 291672 90304484
Upper gastrointestinal haemorrhage 59.90 13.27 56 32235 22920 90573236
Melaena 58.48 13.27 67 32224 34730 90561426
Gamma-glutamyltransferase increased 57.02 13.27 69 32222 37883 90558273
Gastrointestinal haemorrhage 55.09 13.27 108 32183 90140 90506016
Infusion related reaction 54.91 13.27 41 32250 416739 90179417
Ill-defined disorder 53.67 13.27 3 32288 184888 90411268
Venous pressure jugular decreased 53.52 13.27 10 32281 39 90596117
Biliary sepsis 53.21 13.27 18 32273 968 90595188
Blood creatine increased 52.31 13.27 32 32259 6935 90589221
Blue toe syndrome 52.10 13.27 15 32276 471 90595685
Depression 52.01 13.27 21 32270 300580 90295576
Arteriovenous fistula occlusion 51.41 13.27 14 32277 357 90595799
Dermatitis exfoliative 50.94 13.27 29 32262 5507 90590649
Foetal growth restriction 50.56 13.27 35 32256 9345 90586811
Truncus arteriosus persistent 50.33 13.27 14 32277 387 90595769
Musculoskeletal stiffness 49.24 13.27 22 32269 296510 90299646
Type 2 diabetes mellitus 49.13 13.27 7 32284 203237 90392919
Hyperkalaemia 48.77 13.27 85 32206 64879 90531277
Headache 48.73 13.27 152 32139 862594 89733562
Hyperthyroidism 48.45 13.27 45 32246 18265 90577891
Mobility decreased 47.66 13.27 15 32276 250719 90345437
Congenital cardiovascular anomaly 47.34 13.27 14 32277 484 90595672
Analgesic therapy 47.31 13.27 15 32276 657 90595499
Injury 47.23 13.27 7 32284 197342 90398814
Multiple epiphyseal dysplasia 45.74 13.27 10 32281 97 90596059
Antacid therapy 45.61 13.27 15 32276 739 90595417
Appendicolith 45.47 13.27 15 32276 746 90595410
Hypoaesthesia 45.26 13.27 28 32263 314182 90281974
Skeletal dysplasia 44.85 13.27 10 32281 107 90596049
Pain 44.79 13.27 193 32098 996148 89600008
Drug therapy 44.57 13.27 15 32276 794 90595362
Anticoagulant therapy 44.43 13.27 15 32276 802 90595354
Vessel puncture site bruise 44.13 13.27 13 32278 443 90595713
Epistaxis 43.86 13.27 95 32196 85030 90511126
Malignant neoplasm progression 43.79 13.27 109 32182 106761 90489395
Gastric ulcer 43.03 13.27 51 32240 27397 90568759
Cerebral haemorrhage foetal 43.00 13.27 12 32279 336 90595820
Cerebral haemorrhage 42.74 13.27 57 32234 34465 90561691
Pleural effusion 42.54 13.27 111 32180 111880 90484276
Pituitary tumour 42.54 13.27 15 32276 914 90595242
Mucosal erosion 42.24 13.27 18 32273 1827 90594329
Wheezing 42.21 13.27 16 32275 238064 90358092
Adrenal suppression 41.33 13.27 15 32276 994 90595162
Cardiac septal defect 41.07 13.27 14 32277 771 90595385
Acute generalised exanthematous pustulosis 40.82 13.27 36 32255 13667 90582489
Haemoptysis 39.70 13.27 54 32237 33266 90562890
Hypersensitivity 39.65 13.27 63 32228 454614 90141542
Hepatitis cholestatic 39.37 13.27 29 32262 8532 90587624
Schizencephaly 38.62 13.27 11 32280 332 90595824
Brachydactyly 37.87 13.27 10 32281 226 90595930
Blood loss anaemia 37.12 13.27 30 32261 10110 90586046
Drug hypersensitivity 36.98 13.27 68 32223 463541 90132615
Embolism 36.74 13.27 29 32262 9452 90586704
Body dysmorphic disorder 36.66 13.27 11 32280 400 90595756
Normal newborn 35.95 13.27 43 32248 23319 90572837
Abdominal wall haemorrhage 35.92 13.27 9 32282 164 90595992
Diarrhoea haemorrhagic 35.80 13.27 30 32261 10633 90585523
Blood uric acid increased 35.21 13.27 26 32265 7678 90588478
Multiple organ dysfunction syndrome 34.90 13.27 76 32215 68260 90527896
Retroperitoneal haematoma 34.69 13.27 19 32272 3349 90592807
Leukopenia 34.41 13.27 96 32195 100614 90495542
Contraindicated product administered 34.39 13.27 38 32253 320101 90276055
International normalised ratio increased 34.34 13.27 61 32230 47255 90548901
Asthma 34.28 13.27 22 32269 242138 90354018
Erythema 34.23 13.27 167 32124 229079 90367077
Febrile bone marrow aplasia 33.95 13.27 28 32263 9710 90586446
Electrolyte imbalance 33.77 13.27 42 32249 23703 90572453
Product use issue 33.46 13.27 41 32250 329878 90266278
Hyperphosphataemia 32.96 13.27 19 32272 3692 90592464
Cardiac failure 32.26 13.27 99 32192 109397 90486759
Muscle haemorrhage 32.06 13.27 18 32273 3328 90592828
Joint range of motion decreased 32.02 13.27 5 32286 135638 90460518
Ovarian hyperstimulation syndrome 31.89 13.27 22 32269 5840 90590316
Hypokalaemia 31.84 13.27 111 32180 131005 90465151
Neoplasm progression 31.83 13.27 57 32234 44429 90551727
Migraine 31.79 13.27 14 32277 190378 90405778
Caesarean section 31.60 13.27 36 32255 18541 90577615
Pneumothorax traumatic 31.27 13.27 8 32283 159 90595997
Genital erosion 31.21 13.27 10 32281 453 90595703
Abortion induced 31.03 13.27 29 32262 11859 90584297
Heart disease congenital 30.98 13.27 14 32277 1635 90594521
Peripheral swelling 30.84 13.27 63 32228 413043 90183113
Retroperitoneal haemorrhage 30.69 13.27 17 32274 3063 90593093
Cholecystitis 30.66 13.27 34 32257 17006 90579150
Abdominal pain 30.43 13.27 243 32048 395478 90200678
Gastrointestinal disorder 30.38 13.27 28 32263 256659 90339497
Shock haemorrhagic 30.30 13.27 29 32262 12216 90583940
Therapy non-responder 30.17 13.27 6 32285 136698 90459458
Intra-abdominal haemorrhage 30.16 13.27 16 32275 2646 90593510
Fatigue 30.10 13.27 265 32026 1153758 89442398
Gestational diabetes 29.93 13.27 27 32264 10555 90585601
Blood alkaline phosphatase increased 29.89 13.27 58 32233 48021 90548135
Swelling 29.54 13.27 66 32225 418992 90177164
Bacteraemia 29.43 13.27 38 32253 22262 90573894
Memory impairment 29.20 13.27 17 32274 197227 90398929
Eosinophilia 29.19 13.27 43 32248 28490 90567666
Pyrexia 29.04 13.27 361 31930 660124 89936032
Haemorrhage 28.67 13.27 71 32220 69298 90526858
Cardiac hypertrophy 28.66 13.27 12 32279 1166 90594990
Gastrointestinal toxicity 28.46 13.27 25 32266 9442 90586714
Perforation 28.45 13.27 14 32277 1980 90594176
Interstitial lung disease 28.27 13.27 75 32216 76330 90519826
Hydronephrosis 28.13 13.27 28 32263 12374 90583782
Blood phosphorus increased 27.82 13.27 18 32273 4300 90591856
Road traffic accident 27.72 13.27 3 32288 107623 90488533
Joint ankylosis 27.49 13.27 12 32279 1291 90594865
Gait inability 27.39 13.27 9 32282 146447 90449709
Insomnia 27.39 13.27 48 32243 333426 90262730
C-reactive protein abnormal 27.28 13.27 6 32285 127423 90468733
Cerebral infarction 27.10 13.27 40 32251 26556 90569600
Weight increased 26.93 13.27 69 32222 417858 90178298
Cardiomyopathy acute 26.74 13.27 8 32283 288 90595868
Cardiogenic shock 26.68 13.27 38 32253 24430 90571726
Fracture blisters 26.13 13.27 6 32285 74 90596082
Hepatic enzyme increased 26.09 13.27 56 32235 360680 90235476
Thrombophlebitis 25.99 13.27 18 32273 4810 90591346
Restlessness 25.85 13.27 46 32245 35674 90560482
Gastric antral vascular ectasia 25.52 13.27 10 32281 819 90595337
Maternal exposure during pregnancy 25.47 13.27 217 32074 359846 90236310
Bone marrow eosinophilic leukocyte count increased 25.43 13.27 5 32286 27 90596129
Abortion spontaneous 25.22 13.27 58 32233 53998 90542158
Femoral neck fracture 24.88 13.27 24 32267 10209 90585947
Osteoarthritis 24.80 13.27 20 32271 195710 90400446
Faecaloma 24.49 13.27 24 32267 10407 90585749
Cerebellar haematoma 24.37 13.27 8 32283 392 90595764
Blood cholesterol increased 24.24 13.27 23 32268 207989 90388167
Ventricular septal defect 24.15 13.27 18 32273 5389 90590767
Allergic hepatitis 24.07 13.27 5 32286 37 90596119
Hypothalamo-pituitary disorder 24.01 13.27 13 32278 2239 90593917
Feeling abnormal 23.93 13.27 15 32276 167220 90428936
Humerus fracture 23.89 13.27 23 32268 9762 90586394
Gait disturbance 23.73 13.27 35 32256 260461 90335695
Device operational issue 23.61 13.27 10 32281 1000 90595156
Peritonitis 23.57 13.27 32 32259 19673 90576483
Alanine aminotransferase increased 23.57 13.27 94 32197 118244 90477912
Malnutrition 23.52 13.27 31 32260 18527 90577629
Therapeutic embolisation 23.34 13.27 7 32284 254 90595902
Subcutaneous haematoma 23.28 13.27 12 32279 1871 90594285
Psychiatric decompensation 22.93 13.27 12 32279 1931 90594225
Rash 22.88 13.27 178 32113 795922 89800234
Nasopharyngitis 22.70 13.27 72 32219 407032 90189124
Neonatal respiratory distress syndrome 22.66 13.27 14 32277 3087 90593069
Haemorrhagic erosive gastritis 22.63 13.27 8 32283 491 90595665
Toxic skin eruption 22.59 13.27 28 32263 15746 90580410
Vena cava thrombosis 22.49 13.27 13 32278 2539 90593617
Malaise 22.45 13.27 120 32171 585866 90010290
Foetal exposure during pregnancy 22.17 13.27 48 32243 42927 90553229
Liver injury 22.15 13.27 17 32274 170550 90425606
Internal fixation of fracture 22.10 13.27 9 32282 815 90595341
Anaphylactic reaction 22.03 13.27 75 32216 87449 90508707
Hyperlipasaemia 22.03 13.27 9 32282 822 90595334
Therapeutic product effect incomplete 21.95 13.27 22 32269 193874 90402282
Intra-abdominal haematoma 21.82 13.27 12 32279 2132 90594024
Posture abnormal 21.76 13.27 13 32278 2698 90593458
Pneumobilia 21.60 13.27 6 32285 165 90595991
Stevens-Johnson syndrome 21.48 13.27 38 32253 29338 90566818
Renal failure 21.41 13.27 98 32193 130909 90465247
Haemorrhagic thyroid cyst 21.33 13.27 4 32287 16 90596140
Sciatica 21.25 13.27 5 32286 101377 90494779
Pericardial effusion 21.17 13.27 43 32248 36790 90559366
Phlebitis 21.10 13.27 19 32272 7411 90588745
Renal tubular acidosis 20.96 13.27 12 32279 2303 90593853
Diarrhoea 20.93 13.27 459 31832 938731 89657425
Bronchopulmonary dysplasia 20.89 13.27 8 32283 616 90595540
Granulomatous liver disease 20.87 13.27 9 32282 940 90595216
Low birth weight baby 20.78 13.27 21 32270 9446 90586710
Limbal swelling 20.77 13.27 4 32287 19 90596137
Gastrointestinal tract adenoma 20.70 13.27 7 32284 376 90595780
Adverse event 20.62 13.27 8 32283 117410 90478746
Maternal drugs affecting foetus 20.47 13.27 16 32275 5139 90591017
Cell death 20.33 13.27 13 32278 3042 90593114
Organ failure 20.14 13.27 13 32278 3092 90593064
Angiogram 20.06 13.27 5 32286 89 90596067
Peripheral venous disease 20.01 13.27 3 32288 83918 90512238
Citrobacter infection 20.00 13.27 8 32283 692 90595464
Loss of personal independence in daily activities 19.76 13.27 12 32279 136093 90460063
Exposure during pregnancy 19.74 13.27 149 32142 238261 90357895
Foetal exposure timing unspecified 19.61 13.27 7 32284 442 90595714
Aortic stenosis 19.58 13.27 17 32274 6319 90589837
Polyneuropathy 19.57 13.27 29 32262 19312 90576844
Catheter site thrombosis 19.42 13.27 7 32284 455 90595701
Rash morbilliform 19.32 13.27 14 32277 4015 90592141
Dizziness 19.22 13.27 127 32164 589157 90006999
Disease progression 19.16 13.27 108 32183 156507 90439649
Peripheral ischaemia 19.14 13.27 16 32275 5651 90590505
Upper respiratory tract infection 19.07 13.27 11 32280 128307 90467849
Protein S decreased 18.98 13.27 4 32287 32 90596124
Haemolysis 18.90 13.27 19 32272 8491 90587665
Subcutaneous abscess 18.84 13.27 17 32274 6649 90589507
Adverse drug reaction 18.82 13.27 9 32282 116692 90479464
Clostridium difficile colitis 18.82 13.27 34 32257 26672 90569484
Respiratory distress 18.40 13.27 42 32249 38904 90557252
Hyperdynamic left ventricle 18.39 13.27 6 32285 288 90595868
Sudden death 18.32 13.27 21 32270 10888 90585268
Blood calcium increased 18.23 13.27 22 32269 12036 90584120
Lower limb fracture 18.20 13.27 4 32287 85009 90511147
Haemangioma congenital 18.15 13.27 7 32284 549 90595607
Protein C decreased 18.09 13.27 4 32287 41 90596115
Catheter site injury 17.97 13.27 6 32285 310 90595846
Cholestatic liver injury 17.77 13.27 13 32278 3784 90592372
Therapeutic response decreased 17.71 13.27 5 32286 89724 90506432
Musculoskeletal pain 17.64 13.27 21 32270 171230 90424926
Knee arthroplasty 17.64 13.27 4 32287 83178 90512978
Lordosis 17.62 13.27 6 32285 329 90595827
Aspartate aminotransferase increased 17.56 13.27 78 32213 102859 90493297
Hip arthroplasty 17.55 13.27 3 32288 76205 90519951
Hypotonia 17.53 13.27 21 32270 11405 90584751
Tubulointerstitial nephritis 17.53 13.27 32 32259 25311 90570845
Urinary tract infection 17.46 13.27 176 32115 305456 90290700
Vena cava filter insertion 17.31 13.27 5 32286 159 90595997
Acidosis 17.27 13.27 22 32269 12714 90583442
Haemorrhagic stroke 17.25 13.27 16 32275 6480 90589676
Anterior segment ischaemia 17.15 13.27 4 32287 53 90596103
Device related infection 17.13 13.27 32 32259 25754 90570402
Intentional product use issue 17.10 13.27 32 32259 216860 90379296
Mucosal inflammation 16.87 13.27 52 32239 57573 90538583
Dental fistula 16.82 13.27 7 32284 670 90595486
Liver iron concentration abnormal 16.82 13.27 4 32287 58 90596098
Skin warm 16.78 13.27 17 32274 7670 90588486
Cardiac arrest 16.77 13.27 78 32213 104857 90491299
Hepatic function abnormal 16.67 13.27 45 32246 46243 90549913
Cyanosis 16.65 13.27 27 32264 19428 90576728
Reticulocyte count increased 16.56 13.27 8 32283 1087 90595069
Pharyngeal haematoma 16.51 13.27 4 32287 63 90596093
Chest X-ray abnormal 16.45 13.27 14 32277 5068 90591088
Red cell distribution width increased 16.42 13.27 21 32270 12186 90583970
Cerebral haematoma 16.36 13.27 13 32278 4276 90591880
Conjunctivitis 16.33 13.27 32 32259 26674 90569482
Uterine hyperstimulation 16.28 13.27 4 32287 67 90596089
Erysipelas 16.18 13.27 18 32273 9034 90587122
Graft versus host disease 15.96 13.27 17 32274 8127 90588029
Chemotherapeutic drug level increased 15.95 13.27 5 32286 211 90595945
Rectal haemorrhage 15.89 13.27 65 32226 82679 90513477
Deep vein thrombosis postoperative 15.85 13.27 3 32288 70806 90525350
Autoimmune heparin-induced thrombocytopenia 15.80 13.27 3 32288 13 90596143
Thyroid haemorrhage 15.71 13.27 4 32287 78 90596078
Visual acuity reduced transiently 15.70 13.27 5 32286 222 90595934
Purulent discharge 15.70 13.27 14 32277 5391 90590765
Haemolytic anaemia 15.54 13.27 20 32271 11677 90584479
Sleep disorder therapy 15.45 13.27 6 32285 480 90595676
Psoriasis 15.35 13.27 18 32273 147736 90448420
Antibiotic level above therapeutic 15.30 13.27 6 32285 492 90595664
Night sweats 15.28 13.27 14 32277 128752 90467404
Muscle strain 15.18 13.27 18 32273 9669 90586487
Glomerular filtration rate decreased 15.18 13.27 24 32267 16908 90579248
Arteriovenous fistula site complication 15.18 13.27 6 32285 503 90595653
Persecutory delusion 15.05 13.27 11 32280 3197 90592959
Prescribed overdose 15.04 13.27 8 32283 97617 90498539
Cholelithiasis 15.02 13.27 47 32244 52459 90543697
Urticaria 14.96 13.27 59 32232 312675 90283481
Magnetic resonance imaging head abnormal 14.87 13.27 10 32281 2546 90593610
Post procedural haematoma 14.85 13.27 8 32283 1364 90594792
Anaemia folate deficiency 14.77 13.27 6 32285 540 90595616
Lymphopenia 14.71 13.27 28 32263 22853 90573303
Dehydration 14.69 13.27 119 32172 194328 90401828
Haemophilus infection 14.63 13.27 8 32283 1406 90594750
Infantile haemangioma 14.61 13.27 4 32287 104 90596052
Transfusion 14.60 13.27 24 32267 17464 90578692
Hepatic hypertrophy 14.59 13.27 3 32288 21 90596135
CSF white blood cell count decreased 14.59 13.27 3 32288 21 90596135
Lacunar infarction 14.55 13.27 11 32280 3366 90592790
Septic shock 14.53 13.27 64 32227 84096 90512060
Venous thrombosis limb 14.30 13.27 11 32280 3451 90592705
Transaminases increased 14.25 13.27 37 32254 37155 90559001
Circulatory collapse 14.22 13.27 29 32262 24875 90571281
Gastrointestinal stoma output increased 14.14 13.27 6 32285 603 90595553
Liver function test abnormal 14.07 13.27 45 32246 50800 90545356
Cholecystitis acute 13.96 13.27 17 32274 9387 90586769
Myoglobin blood increased 13.93 13.27 8 32283 1544 90594612
Thrombosis prophylaxis 13.92 13.27 3 32288 27 90596129
Coma 13.90 13.27 57 32234 72575 90523581
Visual impairment 13.88 13.27 16 32275 132349 90463807
Varicophlebitis 13.82 13.27 3 32288 28 90596128
Arthritis 13.80 13.27 24 32267 167291 90428865
Aortic occlusion 13.73 13.27 4 32287 131 90596025
Muscle spasms 13.71 13.27 45 32246 251838 90344318
Petechiae 13.68 13.27 22 32269 15719 90580437
Ear infection 13.56 13.27 4 32287 69771 90526385
End stage renal disease 13.56 13.27 16 32275 8555 90587601
Rectosigmoid cancer metastatic 13.55 13.27 3 32288 31 90596125
Varices oesophageal 13.45 13.27 11 32280 3768 90592388
Disseminated intravascular coagulation 13.41 13.27 26 32265 21512 90574644
Human chorionic gonadotropin negative 13.38 13.27 3 32288 33 90596123
Alveolitis 13.37 13.27 10 32281 3011 90593145
Injection site pain 13.36 13.27 26 32265 173673 90422483
Prescribed underdose 13.36 13.27 5 32286 75014 90521142
Platelet count decreased 13.30 13.27 89 32202 136880 90459276

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 373.88 14.21 194 34720 13262 42573159
Appendicitis 309.27 14.21 199 34715 20414 42566007
General physical health deterioration 262.37 14.21 455 34459 150791 42435630
Cardiogenic shock 236.00 14.21 211 34703 35429 42550992
Stress 190.48 14.21 207 34707 44005 42542416
Blood phosphorus increased 188.01 14.21 121 34793 12404 42574017
Ventricular fibrillation 186.96 14.21 172 34742 29951 42556470
Ascites 180.15 14.21 227 34687 56451 42529970
Drug ineffective 161.40 14.21 168 34746 630029 41956392
Multiple organ dysfunction syndrome 160.29 14.21 286 34628 96749 42489672
Hyponatraemia 158.65 14.21 292 34622 101170 42485251
Myasthenia gravis 144.98 14.21 114 34800 16023 42570398
Hyperphosphataemia 143.75 14.21 104 34810 12900 42573521
Abdominal distension 136.24 14.21 225 34689 71510 42514911
Sepsis 119.78 14.21 397 34517 198937 42387484
Analgesic therapy 115.48 14.21 70 34844 6454 42579967
Blood uric acid increased 112.78 14.21 97 34817 15450 42570971
Sleep disorder therapy 111.92 14.21 70 34844 6824 42579597
Drug therapy 106.65 14.21 66 34848 6314 42580107
Hypophosphataemia 104.30 14.21 106 34808 20839 42565582
Dry mouth 103.95 14.21 145 34769 39734 42546687
Pulmonary embolism 102.09 14.21 270 34644 119342 42467079
Incorrect route of product administration 101.49 14.21 112 34802 24193 42562228
Abdominal pain 100.15 14.21 363 34551 190108 42396313
Bacterial infection 98.76 14.21 118 34796 27761 42558660
Neuralgia 88.30 14.21 107 34807 25540 42560881
Activated partial thromboplastin time prolonged 81.95 14.21 82 34832 15821 42570600
Antacid therapy 81.91 14.21 50 34864 4667 42581754
Anticoagulant therapy 78.57 14.21 48 34866 4487 42581934
Toxicity to various agents 77.30 14.21 46 34868 229090 42357331
Iron deficiency 76.16 14.21 67 34847 10994 42575427
Blood cholesterol increased 75.36 14.21 101 34813 26640 42559781
Drug abuse 69.66 14.21 4 34910 104767 42481654
Hepatocellular injury 69.14 14.21 91 34823 23587 42562834
Toxic epidermal necrolysis 67.81 14.21 96 34818 26654 42559767
Thrombosis 63.90 14.21 160 34754 68351 42518070
Shock haemorrhagic 61.25 14.21 71 34843 16171 42570250
Heparin-induced thrombocytopenia 60.09 14.21 47 34867 6550 42579871
Lymph node calcification 56.61 14.21 15 34899 141 42586280
Chronic obstructive pulmonary disease 54.30 14.21 143 34771 62971 42523450
Ulcer 54.00 14.21 67 34847 16374 42570047
Thrombocytopenia 51.94 14.21 299 34615 189980 42396441
Lower respiratory tract infection 51.44 14.21 108 34806 41098 42545323
Acute kidney injury 49.86 14.21 489 34425 366848 42219573
Constipation 49.61 14.21 263 34651 162028 42424393
Dizziness 46.68 14.21 83 34831 249171 42337250
Congenital hiatus hernia 45.74 14.21 39 34875 6135 42580286
Diabetes mellitus 44.60 14.21 129 34785 59958 42526463
Bronchopulmonary aspergillosis allergic 44.59 14.21 34 34880 4564 42581857
Haematemesis 43.48 14.21 84 34830 30115 42556306
Respiratory tract infection bacterial 43.11 14.21 24 34890 1885 42584536
Feeling abnormal 42.57 14.21 4 34910 69782 42516639
Depression 42.49 14.21 19 34895 111344 42475077
Blood calcium increased 42.46 14.21 43 34871 8411 42578010
Anaemia 41.39 14.21 380 34534 279898 42306523
End stage renal disease 41.33 14.21 59 34855 16499 42569922
Bacteroides infection 41.31 14.21 26 34888 2561 42583860
Swelling 40.90 14.21 118 34796 54767 42531654
Troponin increased 40.53 14.21 63 34851 18999 42567422
Arthralgia 39.63 14.21 67 34847 205171 42381250
Therapeutic product effect incomplete 38.53 14.21 6 34908 70933 42515488
Aortic stenosis 37.71 14.21 41 34873 8704 42577717
Sleep disorder 37.39 14.21 105 34809 47990 42538431
Blood test abnormal 36.74 14.21 49 34865 12857 42573564
Tumour fistulisation 36.08 14.21 10 34904 113 42586308
Hepatic cytolysis 35.42 14.21 72 34842 26772 42559649
Cardiac failure congestive 35.26 14.21 13 34901 85589 42500832
Death 33.71 14.21 237 34677 470948 42115473
Gout 33.24 14.21 72 34842 27983 42558438
Respiratory tract infection viral 32.62 14.21 25 34889 3381 42583040
Intentional overdose 31.25 14.21 3 34911 51453 42534968
Insomnia 30.61 14.21 31 34883 118222 42468199
Pleuritic pain 30.20 14.21 33 34881 7044 42579377
Hyperlipidaemia 29.93 14.21 59 34855 21457 42564964
Haematoma 29.92 14.21 69 34845 27954 42558467
Pulmonary sarcoidosis 29.52 14.21 14 34900 786 42585635
Aplasia 28.76 14.21 27 34887 4816 42581605
Somnolence 28.74 14.21 206 34708 140899 42445522
Peritoneal haematoma 28.74 14.21 8 34906 92 42586329
Anxiety 28.56 14.21 33 34881 118527 42467894
Vomiting 27.96 14.21 361 34553 289362 42297059
Cholestasis 27.76 14.21 74 34840 32805 42553616
Total lung capacity decreased 27.37 14.21 23 34891 3547 42582874
Splenic vein thrombosis 27.19 14.21 12 34902 570 42585851
Hepatic haematoma 26.92 14.21 11 34903 431 42585990
Bronchial obstruction 26.67 14.21 17 34897 1712 42584709
Treatment failure 26.66 14.21 9 34905 62615 42523806
Suspected product quality issue 25.25 14.21 9 34905 241 42586180
Myalgia 25.08 14.21 25 34889 96055 42490366
Respiratory tract infection 25.07 14.21 62 34852 26260 42560161
Haemorrhage 24.90 14.21 107 34807 60456 42525965
Suicide attempt 24.80 14.21 4 34910 46096 42540325
Bronchial disorder 24.74 14.21 15 34899 1383 42585038
Abdominal discomfort 24.10 14.21 16 34898 75239 42511182
Metastatic malignant melanoma 24.01 14.21 18 34896 2355 42584066
Fall 23.79 14.21 105 34809 234415 42352006
Mucosal inflammation 23.27 14.21 91 34823 49283 42537138
Tooth socket haemorrhage 23.18 14.21 6 34908 51 42586370
Pancytopenia 22.88 14.21 170 34744 117573 42468848
Intentional product misuse 22.18 14.21 105 34809 61795 42524626
Tumour perforation 22.01 14.21 10 34904 509 42585912
Therapeutic product effect decreased 21.98 14.21 3 34911 39147 42547274
Transaminases increased 21.93 14.21 68 34846 32817 42553604
Genitalia external ambiguous 21.85 14.21 8 34906 232 42586189
Premature baby 21.49 14.21 54 34860 23099 42563322
Rash 21.40 14.21 136 34778 276818 42309603
Floppy infant 21.11 14.21 7 34907 150 42586271
Mucosal disorder 20.91 14.21 16 34898 2158 42584263
Portal vein thrombosis 20.79 14.21 22 34892 4527 42581894
Muscle haemorrhage 20.75 14.21 21 34893 4104 42582317
Hyperthermia 20.62 14.21 37 34877 12537 42573884
Congenital bladder anomaly 20.59 14.21 8 34906 274 42586147
Hypertrophic osteoarthropathy 20.47 14.21 6 34908 84 42586337
Blood loss anaemia 20.44 14.21 32 34882 9704 42576717
Therapeutic response decreased 20.39 14.21 3 34911 37009 42549412
Product dose omission issue 20.32 14.21 62 34852 154303 42432118
Embolism 20.09 14.21 30 34884 8733 42577688
Febrile neutropenia 19.86 14.21 236 34678 185467 42400954
Mental status changes 19.85 14.21 5 34909 42110 42544311
Loss of personal independence in daily activities 19.79 14.21 8 34906 49808 42536613
Overdose 19.71 14.21 35 34879 105229 42481192
Hyperkalaemia 19.70 14.21 123 34791 80335 42506086
Upper gastrointestinal haemorrhage 19.60 14.21 62 34852 30237 42556184
Lung opacity 19.51 14.21 24 34890 5813 42580608
Device related bacteraemia 19.45 14.21 10 34904 669 42585752
Neutropenia 18.99 14.21 248 34666 199183 42387238
Behaviour disorder 18.89 14.21 26 34888 7028 42579393
Anastomotic infection 18.57 14.21 6 34908 118 42586303
Joint swelling 18.56 14.21 17 34897 68005 42518416
Drug hypersensitivity 18.46 14.21 142 34772 99247 42487174
Fatigue 18.42 14.21 249 34665 435392 42151029
Lung cancer metastatic 18.41 14.21 17 34897 2969 42583452
Myocardial infarction 18.40 14.21 47 34867 123962 42462459
Rash maculo-papular 18.39 14.21 70 34844 37433 42548988
Coagulation factor VII level decreased 18.25 14.21 6 34908 125 42586296
Foetal hypokinesia 18.08 14.21 8 34906 382 42586039
Haemorrhagic disorder 18.00 14.21 10 34904 782 42585639
Gait disturbance 17.97 14.21 33 34881 97967 42488454
Hospitalisation 17.56 14.21 21 34893 74309 42512112
Epistaxis 17.52 14.21 104 34810 66722 42519699
Device operational issue 17.43 14.21 7 34907 262 42586159
Bladder tamponade 17.14 14.21 9 34905 629 42585792
Diastasis recti abdominis 16.80 14.21 5 34909 74 42586347
Chondrocalcinosis 16.79 14.21 9 34905 656 42585765
Neonatal respiratory depression 16.72 14.21 8 34906 458 42585963
CSF protein abnormal 16.67 14.21 4 34910 24 42586397
Sinusitis 16.62 14.21 9 34905 47283 42539138
Haemolytic anaemia 16.56 14.21 33 34881 12094 42574327
Pulmonary infarction 16.48 14.21 12 34902 1502 42584919
Abdominal sepsis 16.38 14.21 11 34903 1209 42585212
Neutropenic infection 16.32 14.21 13 34901 1860 42584561
Therapeutic product effect prolonged 16.30 14.21 7 34907 311 42586110
Lung disorder 16.23 14.21 80 34834 47843 42538578
Maternal exposure during pregnancy 16.16 14.21 24 34890 6954 42579467
Needle issue 16.03 14.21 27 34887 8700 42577721
Prothrombin time shortened 15.96 14.21 12 34902 1577 42584844
No adverse event 15.94 14.21 6 34908 39015 42547406
Myopathy 15.94 14.21 35 34879 13726 42572695
Dry skin 15.85 14.21 10 34904 48328 42538093
Headache 15.80 14.21 123 34791 239246 42347175
Antinuclear antibody positive 15.77 14.21 12 34902 1606 42584815
Muscle spasms 15.75 14.21 29 34885 86015 42500406
Respiratory disorder neonatal 15.74 14.21 13 34901 1957 42584464
Oesophagitis 15.68 14.21 37 34877 15210 42571211
Klebsiella infection 15.67 14.21 31 34883 11301 42575120
Vascular device infection 15.58 14.21 22 34892 6088 42580333
Jaundice cholestatic 15.04 14.21 20 34894 5233 42581188
Cyanosis 14.94 14.21 36 34878 14995 42571426
Septic shock 14.86 14.21 127 34787 91545 42494876
Butterfly rash 14.74 14.21 5 34909 115 42586306
Palpitations 14.70 14.21 12 34902 50785 42535636
Micturition urgency 14.62 14.21 31 34883 11867 42574554
Wrong strength 14.51 14.21 5 34909 121 42586300
Pulmonary artery thrombosis 14.42 14.21 9 34905 873 42585548
Bile acid malabsorption 14.39 14.21 5 34909 124 42586297

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 475.08 12.11 208 62770 14047 110512274
Pulmonary embolism 358.17 12.11 521 62457 213953 110312368
Appendicitis 357.31 12.11 215 62763 28249 110498072
General physical health deterioration 300.82 12.11 713 62265 424582 110101739
Cardiogenic shock 283.79 12.11 246 62732 57092 110469229
Ascites 263.84 12.11 294 62684 92514 110433807
Acute kidney injury 254.47 12.11 867 62111 634563 109891758
Drug ineffective 247.29 12.11 303 62675 1520237 109006084
Blood phosphorus increased 243.58 12.11 138 62840 16202 110510119
Thrombocytopenia 226.30 12.11 566 62412 348319 110178002
Sepsis 224.97 12.11 543 62435 326803 110199518
Multiple organ dysfunction syndrome 222.40 12.11 347 62631 151363 110374958
Toxic epidermal necrolysis 215.65 12.11 210 62768 56517 110469804
Hepatocellular injury 208.67 12.11 196 62782 50446 110475875
Ventricular fibrillation 207.95 12.11 179 62799 41134 110485187
Anaemia 201.11 12.11 726 62252 546360 109979961
Hyperphosphataemia 195.96 12.11 120 62858 16261 110510060
Heparin-induced thrombocytopenia 182.56 12.11 101 62877 11323 110514998
Analgesic therapy 175.90 12.11 85 62893 7199 110519122
Blood uric acid increased 172.97 12.11 123 62855 21406 110504915
Activated partial thromboplastin time prolonged 171.02 12.11 124 62854 22244 110504077
Myasthenia gravis 168.47 12.11 121 62857 21390 110504931
Drug therapy 163.84 12.11 81 62897 7210 110519111
Hyponatraemia 159.08 12.11 370 62608 217283 110309038
Sleep disorder therapy 147.38 12.11 76 62902 7395 110518926
Arthralgia 144.30 12.11 139 62839 779493 109746828
Thrombosis 140.70 12.11 235 62743 108427 110417894
Antacid therapy 135.47 12.11 65 62913 5419 110520902
Arthropathy 131.78 12.11 8 62970 287514 110238807
Anticoagulant therapy 130.78 12.11 63 62915 5298 110521023
Abdominal distension 129.37 12.11 299 62679 174804 110351517
Constipation 127.16 12.11 470 62508 357316 110169005
Stress 126.06 12.11 220 62758 105128 110421193
Completed suicide 123.69 12.11 3 62975 242378 110283943
Bacterial infection 117.52 12.11 138 62840 45898 110480423
Hypophosphataemia 117.12 12.11 118 62860 33064 110493257
Therapeutic product effect decreased 114.41 12.11 6 62972 244310 110282011
Joint swelling 113.74 12.11 55 62923 442790 110083531
Cholestasis 113.74 12.11 161 62817 64357 110461964
Abdominal discomfort 108.89 12.11 44 62934 393814 110132507
Glossodynia 108.73 12.11 4 62974 222000 110304321
Hepatic cytolysis 106.99 12.11 144 62834 54909 110471412
Abdominal pain 106.46 12.11 574 62404 512415 110013906
Sinusitis 102.28 12.11 22 62956 296666 110229655
Systemic lupus erythematosus 100.64 12.11 13 62965 254325 110271996
Shock haemorrhagic 100.04 12.11 99 62879 27148 110499173
Discomfort 98.29 12.11 6 62972 214701 110311620
Pancytopenia 97.02 12.11 301 62677 209312 110317009
Iron deficiency 96.93 12.11 82 62896 18394 110507927
Haematoma 93.01 12.11 139 62839 58337 110467984
Febrile neutropenia 92.99 12.11 392 62586 316375 110209946
Treatment failure 92.67 12.11 22 62956 277212 110249109
Psoriatic arthropathy 91.59 12.11 5 62973 196756 110329565
Rheumatoid arthritis 88.63 12.11 30 62948 299583 110226738
Depression 88.43 12.11 35 62943 317300 110209021
Wound 88.05 12.11 14 62964 234423 110291898
Duodenal ulcer perforation 87.72 12.11 3 62975 177697 110348624
Toxicity to various agents 84.97 12.11 89 62889 480466 110045855
Neuralgia 84.01 12.11 120 62858 48358 110477963
Drug abuse 81.08 12.11 5 62973 177406 110348915
Neutropenic sepsis 79.85 12.11 93 62885 30653 110495668
Folliculitis 78.85 12.11 4 62974 167649 110358672
Cytokine release syndrome 77.89 12.11 142 62836 70164 110456157
Infusion related reaction 77.57 12.11 62 62916 381100 110145221
Ill-defined disorder 76.20 12.11 3 62975 156850 110369471
Pericarditis 76.01 12.11 16 62962 219098 110307223
Upper gastrointestinal haemorrhage 73.90 12.11 115 62863 49981 110476340
Alopecia 73.38 12.11 60 62918 364693 110161628
End stage renal disease 73.29 12.11 75 62903 21398 110504923
Incorrect route of product administration 73.02 12.11 131 62847 63930 110462391
Neutropenia 70.84 12.11 409 62569 374211 110152110
Haematoma muscle 70.44 12.11 38 62940 4052 110522269
Hyperkalaemia 70.37 12.11 203 62775 135593 110390728
Headache 70.33 12.11 262 62716 882115 109644206
Blood creatinine increased 68.89 12.11 245 62733 182644 110343677
Rash maculo-papular 68.82 12.11 139 62839 74083 110452238
Aortic stenosis 68.59 12.11 58 62920 13001 110513320
Mobility decreased 68.11 12.11 25 62953 237397 110288924
Deep vein thrombosis 66.67 12.11 203 62775 139684 110386637
Injury 65.63 12.11 11 62967 177254 110349067
Blood calcium increased 65.21 12.11 65 62913 17975 110508346
Agranulocytosis 63.73 12.11 121 62857 61639 110464682
Drug reaction with eosinophilia and systemic symptoms 62.58 12.11 142 62836 81953 110444368
Haemoglobin decreased 62.53 12.11 294 62684 248433 110277888
Impaired healing 61.19 12.11 18 62960 196699 110329622
Gout 61.14 12.11 89 62889 36477 110489844
Epistaxis 61.02 12.11 188 62790 130184 110396137
Respiratory tract infection bacterial 60.78 12.11 29 62949 2387 110523934
Gamma-glutamyltransferase increased 60.67 12.11 118 62860 61191 110465130
Congenital hiatus hernia 60.29 12.11 40 62938 6219 110520102
Chronic obstructive pulmonary disease 60.29 12.11 167 62811 108991 110417330
Malignant neoplasm progression 58.32 12.11 225 62753 174342 110351979
Troponin increased 58.04 12.11 78 62900 29688 110496633
Insomnia 58.03 12.11 72 62906 360518 110165803
Embolism 57.61 12.11 58 62920 16231 110510090
Type 2 diabetes mellitus 57.39 12.11 15 62963 177217 110349104
Therapeutic product effect incomplete 57.10 12.11 28 62950 223777 110302544
Hypoaesthesia 56.85 12.11 57 62921 314166 110212155
Migraine 56.60 12.11 14 62964 171638 110354683
Dizziness 56.44 12.11 206 62772 697987 109828334
Abdominal wall haematoma 56.27 12.11 37 62941 5668 110520653
Blood loss anaemia 56.22 12.11 60 62918 17965 110508356
Peripheral swelling 54.83 12.11 91 62887 403943 110122378
Hypersensitivity 54.82 12.11 91 62887 403907 110122414
Premature delivery 54.80 12.11 77 62901 30555 110495766
Melaena 54.73 12.11 121 62857 68636 110457685
Feeling abnormal 53.59 12.11 18 62960 180693 110345628
Bursitis 52.95 12.11 6 62972 129912 110396409
C-reactive protein abnormal 52.83 12.11 6 62972 129689 110396632
Ulcer 52.80 12.11 91 62887 43025 110483296
Haematemesis 52.78 12.11 109 62869 58999 110467322
Nasopharyngitis 51.52 12.11 91 62887 394270 110132051
Wheezing 51.29 12.11 42 62936 255188 110271133
Diabetes mellitus 50.93 12.11 148 62830 99233 110427088
Hyperthyroidism 50.06 12.11 72 62906 29189 110497132
Lymph node calcification 49.75 12.11 16 62962 453 110525868
Pain 48.84 12.11 331 62647 954624 109571697
Weight increased 48.60 12.11 104 62874 419540 110106781
Blood test abnormal 48.47 12.11 70 62908 28484 110497837
Jaundice 48.00 12.11 105 62873 59131 110467190
Haemorrhage 47.29 12.11 151 62827 106541 110419780
Bacteroides infection 47.16 12.11 26 62952 2893 110523428
Hyperlipidaemia 47.00 12.11 78 62900 35770 110490551
Cerebral haemorrhage 45.81 12.11 109 62869 64859 110461462
Muscle haemorrhage 45.62 12.11 35 62943 6834 110519487
Gastrointestinal haemorrhage 44.80 12.11 200 62778 165318 110361003
Gait disturbance 44.28 12.11 56 62922 278152 110248169
Product dose omission issue 43.16 12.11 73 62905 321709 110204612
Febrile bone marrow aplasia 42.33 12.11 51 62927 17414 110508907
Venous pressure jugular decreased 42.25 12.11 10 62968 85 110526236
Hepatitis cholestatic 42.09 12.11 51 62927 17515 110508806
Joint range of motion decreased 42.03 12.11 9 62969 121823 110404498
Hepatic enzyme increased 41.94 12.11 74 62904 320818 110205503
Fatigue 41.51 12.11 468 62510 1215490 109310831
Aplasia 41.41 12.11 35 62943 7838 110518483
Bronchopulmonary aspergillosis allergic 41.36 12.11 36 62942 8390 110517931
Transaminases increased 41.13 12.11 103 62875 63287 110463034
Osteoarthritis 40.64 12.11 27 62951 182596 110343725
Pyrexia 40.10 12.11 726 62252 897539 109628782
Blue toe syndrome 40.07 12.11 15 62963 673 110525648
Obesity 39.87 12.11 8 62970 113343 110412978
Rash 39.76 12.11 289 62689 820675 109705646
Blood alkaline phosphatase increased 39.63 12.11 109 62869 70826 110455495
Pleural effusion 39.59 12.11 203 62775 177506 110348815
Arteriovenous fistula occlusion 39.54 12.11 14 62964 535 110525786
Loss of personal independence in daily activities 39.44 12.11 18 62960 150002 110376319
Cardiac failure congestive 38.34 12.11 19 62959 150981 110375340
Needle issue 38.27 12.11 49 62929 17791 110508530
Adverse drug reaction 38.08 12.11 7 62971 105552 110420769
Mucosal inflammation 38.08 12.11 131 62847 96010 110430311
Retroperitoneal haematoma 38.02 12.11 30 62948 6101 110520220
Therapeutic response decreased 37.99 12.11 5 62973 96494 110429827
Tumour fistulisation 37.98 12.11 10 62968 136 110526185
Renal failure 37.45 12.11 239 62739 226335 110299986
Biliary sepsis 37.08 12.11 19 62959 1824 110524497
Respiratory tract infection viral 36.97 12.11 29 62949 5849 110520472
Vessel puncture site bruise 36.41 12.11 13 62965 509 110525812
Malaise 35.73 12.11 230 62748 671589 109854732
Therapy non-responder 35.35 12.11 23 62955 157284 110369037
Haemolytic anaemia 35.09 12.11 51 62927 20869 110505452
Road traffic accident 34.94 12.11 9 62969 107389 110418932
Somnolence 34.36 12.11 288 62690 297161 110229160
Hypokalaemia 34.30 12.11 199 62779 182249 110344072
Peripheral venous disease 33.99 12.11 4 62974 84113 110442208
Liver injury 33.78 12.11 22 62956 150391 110375930
Septic shock 33.74 12.11 178 62800 157350 110368971
Blood creatine increased 33.57 12.11 37 62941 11484 110514837
Behaviour disorder 33.47 12.11 34 62944 9613 110516708
Gait inability 33.38 12.11 18 62960 136358 110389963
Lung opacity 33.23 12.11 37 62941 11615 110514706
Product use issue 33.03 12.11 81 62897 311614 110214707
Hyperthermia 33.01 12.11 50 62928 21222 110505099
Nasal congestion 32.43 12.11 8 62970 98274 110428047
Total lung capacity decreased 32.14 12.11 29 62949 7085 110519236
Neoplasm progression 31.95 12.11 95 62883 64500 110461821
Sciatica 31.52 12.11 7 62971 92392 110433929
Pituitary tumour 31.40 12.11 15 62963 1238 110525083
Memory impairment 30.96 12.11 40 62938 196904 110329417
Adverse event 30.28 12.11 12 62966 108797 110417524
Musculoskeletal stiffness 30.21 12.11 72 62906 279750 110246571
Benign prostatic hyperplasia 29.93 12.11 44 62934 18190 110508131
Phlebitis 29.36 12.11 32 62946 9809 110516512
Peritonitis 28.95 12.11 60 62918 32547 110493774
Intentional overdose 28.92 12.11 20 62958 132481 110393840
Dermatitis exfoliative 28.92 12.11 34 62944 11313 110515008
Hepatic haematoma 28.68 12.11 13 62965 952 110525369
Subcutaneous haematoma 28.27 12.11 19 62959 3017 110523304
Clostridium difficile colitis 28.26 12.11 71 62907 43707 110482614
Treatment noncompliance 28.21 12.11 4 62974 72986 110453335
Acute generalised exanthematous pustulosis 28.21 12.11 47 62931 21617 110504704
Muscle spasms 28.14 12.11 74 62904 278083 110248238
Retroperitoneal haemorrhage 27.94 12.11 25 62953 6040 110520281
Pain in extremity 27.84 12.11 163 62815 486955 110039366
Body dysmorphic disorder 27.23 12.11 10 62968 425 110525896
Adrenal suppression 27.11 12.11 15 62963 1681 110524640
Urticaria 27.09 12.11 92 62886 318765 110207556
Mucosal erosion 27.09 12.11 18 62960 2806 110523515
Autoimmune disorder 26.74 12.11 3 62975 65480 110460841
Intra-abdominal haemorrhage 26.57 12.11 23 62955 5319 110521002
Portal vein thrombosis 26.56 12.11 26 62952 7032 110519289
Thrombophlebitis 26.53 12.11 27 62951 7652 110518669
Pulmonary sarcoidosis 26.50 12.11 15 62963 1757 110524564
Injection site pain 26.09 12.11 38 62940 177884 110348437
Toxic skin eruption 26.06 12.11 52 62926 27463 110498858
Respiratory distress 25.68 12.11 92 62886 68782 110457539
Bronchial obstruction 25.67 12.11 18 62960 3061 110523260
Splenic vein thrombosis 25.20 12.11 12 62966 983 110525338
Lower limb fracture 25.12 12.11 6 62972 75342 110450979
Lung cancer metastatic 24.88 12.11 20 62958 4178 110522143
Leukopenia 24.60 12.11 157 62821 148634 110377687
Limbal swelling 24.53 12.11 5 62973 19 110526302
Oesophagitis 24.52 12.11 52 62926 28663 110497658
Ovarian hyperstimulation syndrome 24.51 12.11 22 62956 5338 110520983
Contraindicated product administered 24.39 12.11 67 62911 248200 110278121
Premature baby 24.35 12.11 21 62957 4834 110521487
Drug interaction 24.30 12.11 410 62568 499773 110026548
Asthma 24.25 12.11 68 62910 250223 110276098
Klebsiella infection 24.19 12.11 42 62936 19967 110506354
Knee arthroplasty 24.10 12.11 4 62974 64944 110461377
Peritoneal haematoma 23.83 12.11 8 62970 260 110526061
Myelosuppression 23.75 12.11 12 62966 94328 110431993
Pleuritic pain 23.73 12.11 37 62941 16103 110510218
Deep vein thrombosis postoperative 23.51 12.11 3 62975 59288 110467033
Tumour perforation 23.41 12.11 10 62968 635 110525686
Fracture blisters 23.26 12.11 6 62972 75 110526246
Pneumothorax traumatic 23.24 12.11 8 62970 281 110526040
Drug intolerance 23.23 12.11 136 62842 406376 110119945
Cell death 23.05 12.11 22 62956 5769 110520552
Gastric ulcer 23.04 12.11 62 62916 39765 110486556
Pulmonary infarction 22.97 12.11 19 62959 4132 110522189
Bone marrow eosinophilic leukocyte count increased 22.94 12.11 5 62973 28 110526293
International normalised ratio increased 22.83 12.11 104 62874 86668 110439653
Bronchial disorder 22.62 12.11 16 62962 2760 110523561
Myalgia 22.61 12.11 59 62919 222322 110303999
Arthritis 22.47 12.11 38 62940 167548 110358773
Night sweats 22.33 12.11 26 62952 133957 110392364
Haemoptysis 22.22 12.11 90 62888 71264 110455057
Cyanosis 22.17 12.11 51 62927 29690 110496631
Intentional product use issue 22.11 12.11 70 62908 247836 110278485
Drug resistance 22.00 12.11 3 62975 56371 110469950
Abdominal wall haemorrhage 21.92 12.11 10 62968 743 110525578
Metastatic malignant melanoma 21.83 12.11 17 62961 3392 110522929
Haemolysis 21.81 12.11 35 62943 15604 110510717
Internal fixation of fracture 21.81 12.11 9 62969 524 110525797
Alanine aminotransferase increased 21.77 12.11 179 62799 183594 110342727
Hip arthroplasty 21.71 12.11 3 62975 55810 110470511
Overdose 21.57 12.11 65 62913 233729 110292592
Normal newborn 21.48 12.11 42 62936 21854 110504467
Injection site reaction 21.44 12.11 12 62966 89058 110437263
Illness 21.37 12.11 10 62968 82161 110444160
Balance disorder 21.23 12.11 21 62957 116539 110409782
Genital erosion 21.21 12.11 10 62968 801 110525520
Influenza 21.18 12.11 40 62938 169061 110357260
Antinuclear antibody positive 20.97 12.11 26 62952 9142 110517179
Ear infection 20.90 12.11 5 62973 62727 110463594
Suspected product quality issue 20.80 12.11 9 62969 590 110525731
No adverse event 20.78 12.11 8 62970 73831 110452490
Cardiomyopathy acute 20.58 12.11 8 62970 398 110525923
Allergic hepatitis 20.49 12.11 5 62973 49 110526272
Psoriasis 20.42 12.11 30 62948 139963 110386358
Visual impairment 20.41 12.11 28 62950 134400 110391921
Amnesia 20.36 12.11 18 62960 105390 110420931
Gestational diabetes 20.28 12.11 23 62955 7366 110518955
Gastric antral vascular ectasia 20.28 12.11 11 62967 1186 110525135
Rectal haemorrhage 20.15 12.11 127 62851 119706 110406615
Hypertrophic osteoarthropathy 20.13 12.11 6 62972 131 110526190
Lymphopenia 19.79 12.11 59 62919 40111 110486210
Anastomotic infection 19.76 12.11 6 62972 140 110526181
Ischaemic stroke 19.75 12.11 60 62918 41203 110485118
Vomiting 19.63 12.11 667 62311 910008 109616313
Eosinophilia 19.60 12.11 75 62903 57861 110468460
Suicide attempt 19.56 12.11 18 62960 103376 110422945
Haemorrhagic thyroid cyst 19.46 12.11 4 62974 16 110526305
Interstitial lung disease 19.44 12.11 141 62837 139193 110387128
Suicidal ideation 19.43 12.11 15 62963 93922 110432399
Vena cava filter insertion 19.40 12.11 6 62972 149 110526172
Haematuria 19.30 12.11 96 62882 82909 110443412
Venous thrombosis 19.26 12.11 24 62954 8481 110517840
Basilar artery occlusion 19.16 12.11 7 62971 293 110526028
Bladder tamponade 19.02 12.11 9 62969 727 110525594
Blepharospasm 19.02 12.11 4 62974 54847 110471474
Compartment syndrome 19.01 12.11 20 62958 5890 110520431
Drug dependence 18.74 12.11 3 62975 50017 110476304
Contusion 18.70 12.11 69 62909 233292 110293029
Duodenal ulcer 18.62 12.11 37 62941 19477 110506844
Peripheral ischaemia 18.61 12.11 27 62951 11031 110515290
Perforation 18.49 12.11 12 62966 1798 110524523
Gastrointestinal disorder 18.45 12.11 73 62905 241879 110284442
Gastrointestinal toxicity 18.44 12.11 27 62951 11121 110515200
Neutropenic infection 18.26 12.11 15 62963 3230 110523091
Tooth socket haemorrhage 18.20 12.11 6 62972 184 110526137
Device operational issue 18.06 12.11 10 62968 1122 110525199
Hypercoagulation 17.94 12.11 15 62963 3311 110523010
CSF protein abnormal 17.84 12.11 4 62974 26 110526295
Vascular device infection 17.84 12.11 33 62945 16479 110509842
Cardiac hypertrophy 17.69 12.11 12 62966 1935 110524386
Micturition urgency 17.68 12.11 36 62942 19284 110507037
Diarrhoea 17.62 12.11 805 62173 1138700 109387621
Hospitalisation 17.59 12.11 34 62944 142459 110383862
Eosinophil percentage decreased 17.59 12.11 7 62971 371 110525950
Reading disorder 17.48 12.11 10 62968 1195 110525126
Back injury 17.41 12.11 3 62975 47396 110478925
Malnutrition 17.35 12.11 44 62934 27235 110499086
Sedation 17.34 12.11 9 62969 69674 110456647
Cerebral haemorrhage foetal 17.34 12.11 3 62975 3 110526318
Coagulation factor VII level decreased 17.31 12.11 6 62972 215 110526106
Pulmonary artery thrombosis 17.30 12.11 11 62967 1591 110524730
Device related bacteraemia 17.29 12.11 10 62968 1220 110525101
Fluid retention 17.16 12.11 17 62961 94290 110432031
Cerebellar haematoma 17.15 12.11 8 62970 626 110525695
Catheter site thrombosis 17.15 12.11 8 62970 626 110525695
Burning sensation 17.13 12.11 9 62969 69203 110457118
Dysgraphia 17.09 12.11 17 62961 4688 110521633
Injection site swelling 16.89 12.11 7 62971 61783 110464538
Thrombocytosis 16.85 12.11 25 62953 10419 110515902
Decubitus ulcer 16.71 12.11 34 62944 18202 110508119
Haemorrhagic diathesis 16.70 12.11 21 62957 7487 110518834
International normalised ratio decreased 16.70 12.11 22 62956 8214 110518107
Exostosis 16.68 12.11 3 62975 45953 110480368
Diarrhoea haemorrhagic 16.58 12.11 31 62947 15608 110510713
Therapy interrupted 16.54 12.11 4 62974 49818 110476503
Superior vena cava syndrome 16.49 12.11 10 62968 1331 110524990
Throat irritation 16.46 12.11 5 62973 53547 110472774
Product quality issue 16.43 12.11 12 62966 77287 110449034
Erysipelas 16.41 12.11 28 62950 13130 110513191
Therapy cessation 16.12 12.11 3 62975 44854 110481467
Uterine hyperstimulation 16.06 12.11 4 62974 43 110526278
Influenza like illness 16.02 12.11 16 62962 88396 110437925
Platelet count decreased 15.97 12.11 201 62777 230242 110296079
Mental status changes 15.95 12.11 12 62966 76110 110450211
Angiogram 15.81 12.11 5 62973 134 110526187
Rash morbilliform 15.75 12.11 21 62957 7930 110518391
Cholecystitis 15.69 12.11 41 62937 25841 110500480
Hypothalamo-pituitary disorder 15.69 12.11 13 62965 2833 110523488
Abdominal sepsis 15.64 12.11 12 62966 2343 110523978
Wrong technique in product usage process 15.60 12.11 16 62962 87332 110438989
Hypovolaemic shock 15.57 12.11 29 62949 14554 110511767
Haemorrhagic erosive gastritis 15.55 12.11 8 62970 774 110525547
Cerebral haematoma 15.46 12.11 23 62955 9609 110516712
Catheter site injury 15.45 12.11 6 62972 298 110526023
Aspartate aminotransferase increased 15.45 12.11 149 62829 159787 110366534
Device related thrombosis 15.42 12.11 14 62964 3448 110522873
Intra-abdominal haematoma 15.38 12.11 14 62964 3458 110522863
Pain in jaw 15.34 12.11 5 62973 51172 110475149
Anterior segment ischaemia 15.29 12.11 4 62974 53 110526268
Erythema 15.28 12.11 242 62736 291205 110235116
Beta-2 glycoprotein antibody positive 15.26 12.11 3 62975 9 110526312
Respiratory symptom 15.07 12.11 29 62949 14916 110511405
Tubulointerstitial nephritis 14.98 12.11 66 62912 54218 110472103
Oedema 14.98 12.11 65 62913 209911 110316410
Dry mouth 14.98 12.11 177 62801 199771 110326550
Pneumobilia 14.97 12.11 6 62972 324 110525997
Liver iron concentration abnormal 14.96 12.11 4 62974 58 110526263
Injection site erythema 14.92 12.11 19 62959 94157 110432164
Livedo reticularis 14.87 12.11 17 62961 5489 110520832
Joint stiffness 14.87 12.11 10 62968 67233 110459088
Oedema peripheral 14.72 12.11 266 62712 328394 110197927
Autoimmune heparin-induced thrombocytopenia 14.71 12.11 4 62974 62 110526259
Femoral neck fracture 14.70 12.11 26 62952 12541 110513780
Gastrointestinal tract adenoma 14.63 12.11 7 62971 580 110525741
Gastritis 14.60 12.11 65 62913 53634 110472687
Therapeutic embolisation 14.59 12.11 7 62971 583 110525738
Hyperdynamic left ventricle 14.57 12.11 7 62971 585 110525736
Gastrooesophageal reflux disease 14.56 12.11 53 62925 179923 110346398
Viral infection 14.56 12.11 6 62972 53133 110473188
Dental fistula 14.55 12.11 7 62971 587 110525734
Fall 14.51 12.11 249 62729 603233 109923088
Penile necrosis 14.47 12.11 4 62974 66 110526255
Red blood cell sedimentation rate increased 14.38 12.11 14 62964 78288 110448033
Cardiolipin antibody positive 14.35 12.11 5 62973 182 110526139
Mucosal disorder 14.30 12.11 15 62963 4402 110521919
Pruritus 14.29 12.11 239 62739 581321 109945000
Emotional distress 14.13 12.11 4 62974 44843 110481478
Device related infection 14.06 12.11 52 62926 39467 110486854
Glycogen storage disorder 14.05 12.11 3 62975 15 110526306
Cardiac failure 14.01 12.11 166 62812 187460 110338861
Sleep apnoea syndrome 13.92 12.11 3 62975 40444 110485877
Faecaloma 13.91 12.11 28 62950 14880 110511441
Citrobacter infection 13.84 12.11 9 62969 1353 110524968
Venous thrombosis limb 13.79 12.11 16 62962 5249 110521072
Cardiovascular disorder 13.74 12.11 36 62942 22724 110503597
Haemorrhagic disorder 13.74 12.11 10 62968 1803 110524518
Gastrointestinal stoma output increased 13.68 12.11 8 62970 996 110525325
Nail disorder 13.66 12.11 8 62970 57927 110468394
Gonadotrophin deficiency 13.66 12.11 4 62974 82 110526239
IIIrd nerve disorder 13.63 12.11 5 62973 212 110526109
Protein C decreased 13.61 12.11 4 62974 83 110526238
Prescribed overdose 13.54 12.11 18 62960 87563 110438758
Humerus fracture 13.53 12.11 23 62955 10753 110515568
Haemoperitoneum 13.49 12.11 16 62962 5372 110520949
Palpitations 13.47 12.11 46 62932 159166 110367155
Vena cava thrombosis 13.39 12.11 13 62965 3481 110522840
Adenocarcinoma of colon 13.32 12.11 17 62961 6151 110520170
Therapeutic product effect prolonged 13.29 12.11 7 62971 711 110525610
Wrong strength 13.20 12.11 5 62973 232 110526089
Hepatic hypertrophy 13.19 12.11 3 62975 21 110526300
Eye pain 13.18 12.11 6 62972 50093 110476228
Engraftment syndrome 13.17 12.11 10 62968 1922 110524399
Hyperlipasaemia 13.11 12.11 9 62969 1480 110524841
Inflammation 13.07 12.11 61 62917 193177 110333144
Bone marrow disorder 13.07 12.11 14 62964 4209 110522112
Gastritis erosive 12.98 12.11 24 62954 11976 110514345
Caesarean section 12.95 12.11 26 62952 13791 110512530
Chondrocalcinosis 12.93 12.11 10 62968 1975 110524346
Large intestine perforation 12.93 12.11 29 62949 16600 110509721
Joint ankylosis 12.93 12.11 11 62967 2486 110523835
Lordosis 12.89 12.11 6 62972 467 110525854
Acute polyneuropathy 12.85 12.11 7 62971 761 110525560
Clonus 12.84 12.11 20 62958 8696 110517625
Colitis 12.84 12.11 101 62877 102222 110424099
CSF white blood cell count decreased 12.84 12.11 3 62975 24 110526297
Anxiety 12.83 12.11 130 62848 344948 110181373
Thyroid haemorrhage 12.80 12.11 4 62974 103 110526218
Disseminated intravascular coagulation 12.79 12.11 52 62926 41234 110485087
Post procedural pulmonary embolism 12.71 12.11 5 62973 257 110526064
Intracranial pressure increased 12.59 12.11 22 62956 10513 110515808
Electrolyte imbalance 12.58 12.11 48 62930 36980 110489341
Reticulocyte count increased 12.49 12.11 9 62969 1597 110524724
Intentional self-injury 12.44 12.11 3 62975 37426 110488895
Chemotherapeutic drug level increased 12.33 12.11 6 62972 516 110525805
Drug ineffective for unapproved indication 12.29 12.11 25 62953 102813 110423508
Human chorionic gonadotropin negative 12.15 12.11 3 62975 31 110526290

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AB10 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
ATC B01AB12 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
FDA CS M0010191 Heparin, Low-Molecular-Weight
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
FDA EPC N0000175586 Low Molecular Weight Heparin
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:63726 neuroprotective agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:62868 hepatoprotective agent

Related Drugs by ATC class:

B01AB Heparin group 4 drugs
enoxaparin sodiumheparinnadroparin calciumsulodexide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pulmonary embolism indication 59282003 DOID:9477
Deep venous thrombosis indication 128053003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
PUE0TO3XDR UNII
4020894 VANDF
4021054 VANDF
4021237 VANDF
4024199 VANDF
C0916062 UMLSCUI
CHEBI:28304 CHEBI
CHEMBL3707365 ChEMBL_ID
DB09258 DRUGBANK_ID
CHEMBL6068592 ChEMBL_ID
CHEMBL1201448 ChEMBL_ID
CHEMBL1201460 ChEMBL_ID
CHEMBL1201414 ChEMBL_ID
CHEMBL2108806 ChEMBL_ID
C411345 MESH_SUPPLEMENTAL_RECORD_UI
C093450 MESH_SUPPLEMENTAL_RECORD_UI
DB06822 DRUGBANK_ID
104466 RXNORM
15471 MMSL
4531 MMSL
d04659 MMSL
005078 NDDF
007911 NDDF
008338 NDDF
108987000 SNOMEDCT_US
108990006 SNOMEDCT_US
350469004 SNOMEDCT_US
395908006 SNOMEDCT_US
410964003 SNOMEDCT_US
410965002 SNOMEDCT_US
410967005 SNOMEDCT_US
412608008 SNOMEDCT_US
D000078222 MESH_DESCRIPTOR_UI
D017985 MESH_DESCRIPTOR_UI
6985 INN_ID
5688 INN_ID
6764 INN_ID
7501 INN_ID
9005-49-6 SECONDARY_CAS_RN
6846 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0195 INJECTION 2500 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0196 INJECTION 5000 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0206 INJECTION 7500 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0217 INJECTION 10000 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0220 INJECTION 12500 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0223 INJECTION 15000 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0228 INJECTION 18000 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0232 INJECTION 25000 [iU] SUBCUTANEOUS NDA 30 sections
Fragmin HUMAN PRESCRIPTION DRUG LABEL 1 0069-0253 INJECTION 2500 [iU] SUBCUTANEOUS NDA 30 sections