nadroparin calcium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5162 37270-89-6

Description:

MoleculeDescription

Synonyms:

  • nadroparin
  • nadroparin calcium
  • fraxiparine
  • fraxiparin
A low molecular weight heparin (LMWH) composed of a heterogeneous mixture of sulfated polysaccharide glycosaminoglycan chains obtained by depolymerisation of porcine mucosal sodium heparin, extraction/purification and conversion to the calcium salt. Nadroparin binds to antithrombin III (ATIII) and inhibits the activity of activated factor X (factor Xa), thereby inhibiting the final common pathway of the coagulation cascade and preventing the formation of a cross-linked fibrin clot
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.85 TU P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None Health Canada

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lymphatic fistula 168.57 27.61 35 6468 1426 90620518
Femoral hernia incarcerated 167.47 27.61 35 6468 1473 90620471
Wound infection pseudomonas 157.22 27.61 35 6468 1988 90619956
Pancreatic steatosis 153.16 27.61 33 6470 1609 90620335
Arterial haemorrhage 149.53 27.61 35 6468 2488 90619456
Wound dehiscence 143.01 27.61 40 6463 5782 90616162
Seroma 142.81 27.61 35 6468 3025 90618919
Haemarthrosis 128.76 27.61 34 6469 3960 90617984
Aortic valve stenosis 126.75 27.61 34 6469 4206 90617738
Tachyarrhythmia 123.06 27.61 35 6468 5371 90616573
Hepatic cyst 120.66 27.61 36 6467 6532 90615412
Diverticulum intestinal 117.01 27.61 38 6465 9104 90612840
Faecaloma 112.09 27.61 38 6465 10393 90611551
Eructation 110.52 27.61 38 6465 10844 90611100
Aortic arteriosclerosis 106.78 27.61 34 6469 7650 90614294
Groin pain 106.23 27.61 38 6465 12175 90609769
Inflammatory marker increased 104.67 27.61 35 6468 9179 90612765
Cardiovascular disorder 95.24 27.61 36 6467 13456 90608488
Haematuria 93.42 27.61 47 6456 34890 90587054
Escherichia infection 92.98 27.61 37 6466 15858 90606086
Postoperative wound infection 91.80 27.61 35 6468 13391 90608553
Mitral valve incompetence 90.08 27.61 40 6463 22484 90599460
Left ventricular dysfunction 88.79 27.61 35 6468 14634 90607310
Aplastic anaemia 88.60 27.61 34 6469 13235 90608709
Anuria 84.96 27.61 34 6469 14784 90607160
Premature baby 82.88 27.61 39 6464 25038 90596906
Tricuspid valve incompetence 77.63 27.61 33 6470 16698 90605246
Hyponatraemia 75.10 27.61 68 6435 133470 90488474
Myelodysplastic syndrome 73.69 27.61 34 6469 20869 90601075
Urinary retention 73.23 27.61 41 6462 37703 90584241
Cardiogenic shock 71.58 27.61 35 6468 24433 90597511
Osteopenia 70.59 27.61 34 6469 22968 90598976
Premature delivery 69.53 27.61 40 6463 38722 90583222
Pulmonary hypertension 68.68 27.61 41 6462 42482 90579462
Hiatus hernia 67.44 27.61 34 6469 25327 90596617
Anaemia 67.33 27.61 103 6400 352699 90269245
Coronary artery disease 63.80 27.61 36 6467 33587 90588357
Joint dislocation 59.33 27.61 38 6465 44544 90577400
Foetal exposure during pregnancy 53.19 27.61 35 6468 42940 90579004
Oligohydramnios 50.03 27.61 19 6484 7182 90614762
Hyperkalaemia 48.60 27.61 39 6464 64925 90557019
Foetal growth restriction 48.54 27.61 20 6483 9360 90612584
Gastrointestinal haemorrhage 46.89 27.61 44 6459 90204 90531740
Maternal exposure during pregnancy 44.76 27.61 87 6416 359976 90261968
Pelvic haematoma 42.55 27.61 10 6493 722 90621222
Oedema peripheral 40.51 27.61 69 6434 257846 90364098
Low birth weight baby 38.44 27.61 17 6486 9450 90612494
Cerebral thrombosis 38.01 27.61 11 6492 1792 90620152
Toxic epidermal necrolysis 36.66 27.61 25 6478 32503 90589441
Retroperitoneal haemorrhage 32.21 27.61 11 6492 3069 90618875
Anosognosia 30.77 27.61 11 6492 3511 90618433
Acute kidney injury 28.89 27.61 68 6435 320319 90301625
Pain 28.89 27.61 18 6485 996323 89625621
Urinary tract infection 27.70 27.61 65 6438 305567 90316377
Conjunctivitis viral 27.65 27.61 6 6497 302 90621642

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suture rupture 89.61 22.76 18 4068 460 42616789
Soft tissue disorder 73.83 22.76 17 4069 837 42616412
Acetabulum fracture 72.77 22.76 15 4071 437 42616812
Lymphocele 68.57 22.76 18 4068 1529 42615720
Autoimmune disorder 60.11 22.76 18 4068 2469 42614780
Erysipelas 57.77 22.76 22 4064 6274 42610975
SARS-CoV-2 sepsis 50.18 22.76 10 4076 245 42617004
Lymphoedema 47.96 22.76 18 4068 4930 42612319
Pulmonary embolism 41.36 22.76 54 4032 119558 42497691
Impaired healing 36.88 22.76 22 4064 17031 42600218
Eye inflammation 35.96 22.76 13 4073 3205 42614044
Herpes zoster reactivation 34.21 22.76 8 4078 421 42616828
Wound dehiscence 33.86 22.76 13 4073 3787 42613462
Sensitive skin 30.09 22.76 9 4077 1229 42616020
Scrotal pain 27.80 22.76 8 4078 955 42616294
Ileus 27.28 22.76 19 4067 19120 42598129
Hypothalamo-pituitary disorder 26.74 22.76 8 4078 1092 42616157
Umbilical hernia 26.15 22.76 12 4074 5435 42611814
Device related infection 24.04 22.76 18 4068 20261 42596988
Haemolytic uraemic syndrome 23.95 22.76 9 4077 2470 42614779
Dysuria 23.02 22.76 21 4065 31075 42586174

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Wound dehiscence 171.68 20.29 52 9894 7910 110571443
Lymphatic fistula 159.86 20.29 35 9911 1460 110577893
Femoral hernia incarcerated 159.54 20.29 35 9911 1474 110577879
Wound infection pseudomonas 143.22 20.29 35 9911 2376 110576977
Pancreatic steatosis 142.29 20.29 33 9913 1789 110577564
Seroma 132.30 20.29 35 9911 3266 110576087
Arterial haemorrhage 127.24 20.29 35 9911 3784 110575569
Tachyarrhythmia 108.41 20.29 37 9909 8224 110571129
Faecaloma 107.55 20.29 43 9903 14865 110564488
Hepatic cyst 106.61 20.29 36 9910 7747 110571606
Aortic valve stenosis 105.57 20.29 34 9912 6316 110573037
Haemarthrosis 100.78 20.29 34 9912 7295 110572058
Diverticulum intestinal 99.35 20.29 38 9908 11681 110567672
Inflammatory marker increased 94.98 20.29 39 9907 14430 110564923
Eructation 92.65 20.29 38 9908 14019 110565334
Groin pain 89.24 20.29 38 9908 15390 110563963
Aortic arteriosclerosis 87.49 20.29 34 9912 10904 110568449
Postoperative wound infection 85.19 20.29 37 9909 15716 110563637
Escherichia infection 82.25 20.29 41 9905 23775 110555578
Suture rupture 77.94 20.29 17 9929 696 110578657
Cardiovascular disorder 72.21 20.29 37 9909 22723 110556630
Hyponatraemia 70.21 20.29 92 9854 217561 110361792
Mitral valve incompetence 66.71 20.29 40 9906 33289 110546064
Left ventricular dysfunction 65.42 20.29 35 9911 23458 110555895
Haematuria 64.43 20.29 56 9890 82949 110496404
Osteopenia 64.42 20.29 34 9912 22175 110557178
Pulmonary hypertension 63.69 20.29 47 9899 55173 110524180
Tricuspid valve incompetence 62.12 20.29 34 9912 23839 110555514
Acetabulum fracture 61.94 20.29 15 9931 979 110578374
Lymphocele 61.64 20.29 17 9929 1854 110577499
Aplastic anaemia 61.54 20.29 34 9912 24274 110555079
Anuria 61.50 20.29 34 9912 24307 110555046
Joint dislocation 60.68 20.29 38 9908 34152 110545201
Hiatus hernia 60.15 20.29 35 9911 27571 110551782
Anaemia 58.14 20.29 142 9804 546944 110032409
Erysipelas 52.47 20.29 25 9921 13133 110566220
Soft tissue disorder 51.03 20.29 17 9929 3507 110575846
SARS-CoV-2 sepsis 50.42 20.29 10 9936 255 110579098
Myelodysplastic syndrome 50.33 20.29 35 9911 37449 110541904
Urinary retention 50.05 20.29 45 9901 69638 110509715
Premature delivery 46.83 20.29 31 9915 30601 110548752
Cardiogenic shock 39.16 20.29 36 9910 57302 110522051
Pelvic haematoma 36.73 20.29 10 9936 1039 110578314
Maternal exposure during pregnancy 34.61 20.29 73 9873 254810 110324543
Pulmonary embolism 34.59 20.29 66 9880 214408 110364945
Coronary artery disease 34.14 20.29 37 9909 71653 110507700
COVID-19 pneumonia 32.79 20.29 27 9919 37116 110542237
Cerebral thrombosis 32.25 20.29 11 9935 2437 110576916
Oligohydramnios 30.47 20.29 12 9934 3982 110575371
Pain 30.22 20.29 25 9921 954930 109624423
Lymphoedema 30.08 20.29 18 9928 14911 110564442
Urinary tract infection 28.71 20.29 79 9867 326203 110253150
Ileus 28.52 20.29 23 9923 30706 110548647
Headache 26.81 20.29 24 9922 882353 109697000
Anosognosia 26.79 20.29 11 9935 4063 110575290
Gastrointestinal haemorrhage 26.75 20.29 51 9895 165467 110413886
Leukopenia 26.75 20.29 48 9898 148743 110430610
Sepsis 26.59 20.29 77 9869 327269 110252084
Conjunctivitis viral 26.52 20.29 6 9940 291 110579062
Pneumothorax 25.75 20.29 23 9923 35262 110544091
Retroperitoneal haematoma 25.52 20.29 12 9934 6119 110573234
Drug hypersensitivity 25.40 20.29 5 9941 454085 110125268
Respiratory failure 25.06 20.29 58 9888 215274 110364079
Hyperlactacidaemia 24.92 20.29 13 9933 8273 110571080
Hyperkalaemia 24.66 20.29 44 9902 135752 110443601
Oedema peripheral 24.50 20.29 75 9871 328585 110250768
Eye inflammation 23.68 20.29 13 9933 9158 110570195
Impaired healing 22.91 20.29 53 9893 196664 110382689
Nasopharyngitis 22.79 20.29 4 9942 394357 110184996
Retroperitoneal haemorrhage 22.60 20.29 11 9935 6054 110573299
Pneumonia 22.41 20.29 145 9801 876569 109702784
Cachexia 21.93 20.29 14 9932 12991 110566362
Rash 21.88 20.29 25 9921 820939 109758414
Premature baby 21.75 20.29 10 9936 4845 110574508
Dehydration 21.02 20.29 64 9882 279447 110299906
Sensitive skin 20.99 20.29 9 9937 3703 110575650
Hyponatraemic syndrome 20.64 20.29 6 9940 791 110578562

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B01AB06 BLOOD AND BLOOD FORMING ORGANS
ANTITHROMBOTIC AGENTS
ANTITHROMBOTIC AGENTS
Heparin group
MeSH PA D000925 Anticoagulants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D005343 Fibrinolytic Agents
MeSH PA D006401 Hematologic Agents
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50249 anticoagulant

Related Drugs by ATC class:

B01AB Heparin group 4 drugs
bemiparinenoxaparin sodiumheparinsulodexide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Deep venous thrombosis indication 128053003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
LIA7Z4002P UNII
C5848169 UMLSCUI
CHEBI:754093 CHEBI
CHEMBL2109204 ChEMBL_ID
5750 INN_ID
DB08813 DRUGBANK_ID
67031 RXNORM
698278006 SNOMEDCT_US
699946002 SNOMEDCT_US
773473005 SNOMEDCT_US
D017762 MESH_DESCRIPTOR_UI
9005-49-6 SECONDARY_CAS_RN
005821 NDDF
005822 NDDF

Pharmaceutical products:

None