chlormadinone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	600	302-22-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chlormadinone
chlormadinone acetate
chlormadinon
chlormadinon acetate
menstridyl

An orally active synthetic progestational hormone used often in combinations as an oral contraceptive (CONTRACEPTIVES, ORAL).

Molecular weight: 404.93
Formula: C23H29ClO4
CLOGP: 3.98
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 60.44
ALOGS: -5.41
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Meningioma	134.65	42.60	25	677	3860	63484460
Ulnar tunnel syndrome	87.53	42.60	9	693	9	63488311
Diabetic metabolic decompensation	59.13	42.60	11	691	1699	63486621

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Meningioma	116.63	37.28	20	391	4278	79739699
Ulnar tunnel syndrome	93.96	37.28	9	402	10	79743967
Diabetic metabolic decompensation	60.25	37.28	11	400	3321	79740656

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G03AA15	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations
ATC	G03AB07	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, sequential preparations
ATC	G03DB06	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS Pregnadien derivatives
ATC	G03FB03	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM PROGESTOGENS AND ESTROGENS IN COMBINATION Progestogens and estrogens, sequential preparations
MeSH PA	D000726	Androgen Antagonists
MeSH PA	D003270	Contraceptive Agents
MeSH PA	D003271	Contraceptive Agents, Female
MeSH PA	D000080066	Contraceptive Agents, Hormonal
MeSH PA	D003278	Contraceptives, Oral, Hormonal
MeSH PA	D003280	Contraceptives, Oral, Synthetic
MeSH PA	D006727	Hormone Antagonists
MeSH PA	D012102	Reproductive Control Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Endometriosis	indication	129103003
Menorrhagia	indication	386692008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		Ki	7.76		DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	5.52		DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2	Ion channel		AT1A2_PIG		IC50	5.34		DRUG MATRIX
Androgen receptor	Transcription factor		ANDR_RAT		Ki	7.68		DRUG MATRIX
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	9.16		DRUG MATRIX

External reference:

ID	Source
D01299	KEGG_DRUG
2369	RXNORM
C0008214	UMLSCUI
CHEBI:31394	CHEBI
CHEMBL110691	ChEMBL_ID
CHEMBL1697830	ChEMBL_ID
DB13528	DRUGBANK_ID
D002715	MESH_DESCRIPTOR_UI
5284533	PUBCHEM_CID
1210	INN_ID
SDS4N642GG	UNII
DB15903	DRUGBANK_ID
001294	NDDF
004937	NDDF
734645001	SNOMEDCT_US
734647009	SNOMEDCT_US
1961-77-9	SECONDARY_CAS_RN

Pharmaceutical products:

None