demegestone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 803 10116-22-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • demegestone
  • lutionex
a norprogesterone derivative that acts like PROGESTERONE in increasing SEX HORMONE-BINDING GLOBULIN; structure
  • Molecular weight: 312.45
  • Formula: C21H28O2
  • CLOGP: 3.54
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -4.45
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.722 Moderate 0.79
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.748 Moderate 0.79
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 49.774 10^-6 cm/s Moderate 0.79
dh-clint Dog hepatocyte intrinsic clearance 56.885 uL/min/10^6 cells Moderate 0.79
dppb Dog plasma protein binding (% unbound) 1.380 % Moderate 0.79
fcs-ppb Fetal calf serum protein binding (% unbound) 2.330 % Moderate 0.79
herg hERG pIC50 4.707 pIC50 Moderate 0.79
hh-clint Human hepatocyte intrinsic clearance 28.119 uL/min/10^6 cells Moderate 0.79
hlm-clint Human liver microsomal intrinsic clearance 209.894 uL/min/mg protein Moderate 0.79
hppb Human plasma protein binding (% unbound) 1.120 % Moderate 0.79
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1 34
kinase-selectivity-class EIF2AK3,GRK2 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.927 Moderate 0.79
mh-clint Mouse hepatocyte intrinsic clearance 143.219 Moderate 0.79
mppb Mouse plasma protein binding (% unbound) 1.620 Moderate 0.79
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 4.819 Moderate 0.79
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 4.090 % Moderate 0.79
rh-clint Rat hepatocyte intrinsic clearance 115.345 uL/min/10^6 cells Moderate 0.79
rh-fuinc Rat hepatocyte fraction unbound in incubation 14.550 % Moderate 0.79
rppb Rat plasma protein binding (% unbound) 2.560 % Moderate 0.79
solubility-dd Solubility at pH 7.4 in DMSO 16.904 uM Moderate 0.79

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03DB05 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Pregnadien derivatives

Related Drugs by ATC class:

G03DB Pregnadien derivatives 7 drugs
chlormadinonedienogestdydrogesteronemedrogestonemegestrol acetatenomegestrolpromegestone

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07223 KEGG_DRUG
22483 RXNORM
C0057362 UMLSCUI
CHEBI:135339 CHEBI
CHEMBL2104231 ChEMBL_ID
DB13857 DRUGBANK_ID
C011214 MESH_SUPPLEMENTAL_RECORD_UI
93057 PUBCHEM_CID
2935 INN_ID
6E89AM91SZ UNII
005320 NDDF

Pharmaceutical products:

None